Author information: (1)Center for Evidence-Based Healthcare, University Hospital Carl Gustav Carus, Technische Universität Dresden, Fetscherstraße 74, 01307, Dresden, Germany. thomas.datzmann@nct-dresden.de. (2)National Center for Tumor Diseases (NCT), Fetscherstraße 74, 01307, Dresden, Germany. thomas.datzmann@nct-dresden.de. (3)German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120, Heidelberg, Germany. thomas.datzmann@nct-dresden.de. (4)Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Fetscherstraße 74, 01307, Dresden, Germany. thomas.datzmann@nct-dresden.de. (5)Helmholtz-Zentrum Dresden - Rossendorf (HZDR), Bautzner Landstraße 400, 01328, Dresden, Germany. thomas.datzmann@nct-dresden.de. (6)University Comprehensive Spine Center (UCSC), University Center for Orthopedics, Traumatology and Plastic Surgery, University Hospital Carl Gustav Carus, Technische Universität Dresden, Fetscherstraße 74, 01307, Dresden, Germany. (7)Department of Trauma and Orthopedic Surgery, Center for Surgical Medicine, University Hospital Hamburg Eppendorf, Martinistraße 52, 20246, Hamburg, Germany. (8)Orthopedic University Hospital Friedrichsheim, Marienburgstraße 2, 60528, Frankfurt (Main), Germany. (9)Spine Surgery, University Hospital Basel, Spitalstrasse 21, 4031, Basel, Switzerland. (10)Center for Evidence-Based Healthcare, University Hospital Carl Gustav Carus, Technische Universität Dresden, Fetscherstraße 74, 01307, Dresden, Germany. (11)National Center for Tumor Diseases (NCT), Fetscherstraße 74, 01307, Dresden, Germany. (#)Contributed equally