Author information: (1)Department of Medical Genetics, Hospital Universitario de Navarra, IdiSNA, Pamplona 31008, Spain. (2)Department of Health Sciences, Universidad Pública de Navarra, IdiSNA, Pamplona 31008, Spain. (3)Fundación Miguel Servet-Navarrabiomed, IdiSNA, Pamplona 31008, Spain. (4)Department of Statistics, Informatics and Mathematics, Universidad Pública de Navarra, IdiSNA, Pamplona 31006, Spain. (5)School of Molecular Biosciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G12 8QQ, UK.