Author information: (1)Department of Pediatrics, Columbia University Irving Medical Center, 1150 St. Nicholas Avenue, Room 620, New York, NY, 10032, USA. (2)Department of Systems Biology, Columbia University, New York, NY, USA. (3)Department of Medicine, University of Cambridge, Cambridge Biomedical Campus, Cambridge, UK. (4)Division of Human Genetics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA. (5)Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA. (6)42Genetics, Belfast, Ireland. (7)NIHR BioResource for Translational Research, Cambridge Biomedical Campus, Cambridge, UK. (8)Regeneron Pharmaceuticals, New York, NY, USA. (9)Department of Infection, Immunity and Cardiovascular Disease, University of Sheffield, Sheffield, UK. (10)Department of Medical and Molecular Genetics, King's College London, London, UK. (11)National Heart & Lung Institute, Imperial College London, London, UK. (12)Addenbrooke's Hospital NHS Foundation Trust, Cambridge Biomedical Campus, Cambridge, UK. (13)Royal Papworth Hospital NHS Foundation Trust, Cambridge Biomedical Campus, Cambridge, UK. (14)Department of Biomedical Informatics, Columbia University, New York, NY, USA. (15)Department of Haematology, University of Cambridge, Cambridge Biomedical Campus, Cambridge, UK. (16)Department of Pediatrics, Columbia University Irving Medical Center, 1150 St. Nicholas Avenue, Room 620, New York, NY, 10032, USA. wkc15@columbia.edu. (17)Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, NY, USA. wkc15@columbia.edu. (18)Department of Medicine, Columbia University Irving Medical Center, New York, NY, USA. wkc15@columbia.edu. (#)Contributed equally