生信网-文献期刊

Viruses

2022 Jul 9

Aston EJ, Wallach MG, Narayanan A

2. Cell and Animal Models for SARS-CoV-2 Research.

Viruses

2022 Jul 9

Bestion E, Halfon P, Mezouar S

3. Polymorphic Forms of Human Cytomegalovirus Glycoprotein O Protect against Neutralization of Fibroblast Entry by Antibodies Targeting Epitopes Defined by Glycoproteins H and L.

Viruses

2022 Jul 9

He L, Taylor S, Costa C

4. SARS-CoV-2 Testing of Aircraft Wastewater Shows That Mandatory Tests and Vaccination Pass before Boarding Did Not Prevent Massive Importation of Omicron Variant into Europe.

Viruses

2022 Jul 9

Le Targa L, Wurtz N, Lacoste A

5. Avian IRF1 and IRF7 Play Overlapping and Distinct Roles in Regulating IFN-Dependent and -Independent Antiviral Responses to Duck Tembusu Virus Infection.

Viruses

2022 Jul 9

Xiang C, Yang Z, Xiong T

6. Outreach Efforts to Prevent Newcastle Disease Outbreaks in Southern California.

Viruses

2022 Jul 9

Figueroa A, Escobedo E, Solis M

7. Translation of SARS-CoV-2 gRNA Is Extremely Efficient and Competitive despite a High Degree of Secondary Structures and the Presence of an uORF.

Viruses

2022 Jul 8

Condé L, Allatif O, Ohlmann T

8. In Vitro Growth, Receptor Usage and Pathogenesis of Feline Morbillivirus in the Natural Host.

Viruses

2022 Jul 8

Nikolin V, Hatsue Sobreda Doi L, Sieg M

9. Special Issue "Lentiviral Vectors".

Viruses

2022 Jul 8

Takeuchi Y.

10. Allele-Specific Dual PCRs to Identify Members of the 27a Cluster of PPV.

Viruses

2022 Jul 8

Tamás V, Mészáros I, Olasz F

11. Impact of Chemical Properties of Human Respiratory Droplets and Aerosol Particles on Airborne Viruses' Viability and Indoor Transmission.

Viruses

2022 Jul 8

Ahlawat A, Mishra SK, Herrmann H

12. Cross-Serotype Reactivity of ELISAs Used to Detect Antibodies to the Structural Proteins of Foot-and-Mouth Disease Virus.

Viruses

2022 Jul 8

Ludi AB, Morris A, Gubbins S

13. Understanding Immune Responses to Viruses-Do Underlying Th1/Th2 Cell Biases Predict Outcome?

Viruses

2022 Jul 8

Howard FHN, Kwan A, Winder N

14. Reporter Flaviviruses as Tools to Demonstrate Homologous and Heterologous Superinfection Exclusion.

Viruses

2022 Jul 8

Torres FJ, Parry R, Hugo LE

15. Pigeon Circovirus over Three Decades of Research: Bibliometrics, Scoping Review, and Perspectives.

Viruses

2022 Jul 8

Silva BBI, Urzo MLR, Encabo JR

16. Timely Hepatitis C RNA Testing and Treatment in the Era of Direct-Acting Antiviral Therapy among People with Hepatitis C in New South Wales, Australia.

Viruses

2022 Jul 8

Yousafzai MT, Alavi M, Valerio H

17. Kinetics of the SARS-CoV-2 Antibody Avidity Response Following Infection and Vaccination.

Viruses

2022 Jul 8

Garcia L, Woudenberg T, Rosado J

18. Occult Hepatitis B Virus Infection: An Update.

Viruses

2022 Jul 8

Saitta C, Pollicino T, Raimondo G.

19. Efficacy of Western, Eastern, and Venezuelan Equine Encephalitis (WEVEE) Virus-Replicon Particle (VRP) Vaccine against WEEV in a Non-Human Primate Animal Model.

Viruses

2022 Jul 8

Burke CW, Erwin-Cohen RA, Goodson AI

20. Human Platelet Lysate Induces Antiviral Responses against Parechovirus A3.

Viruses

2022 Jul 8

Jan MW, Chiu CY, Chen JJ

21. Comparative Dynamics of Delta and Omicron SARS-CoV-2 Variants across and between California and Mexico.

Viruses

2022 Jul 8

Mehta SR, Smith DM, Boukadida C

22. In Vitro Techniques and Measurements of Phage Characteristics That Are Important for Phage Therapy Success.

Viruses

2022 Jul 7

Glonti T, Pirnay JP.

23. The Self-Reported Leeds Assessment of Neuropathic Symptoms and Signs (S-LANSS) and PainDETECT Questionnaires in COVID-19 Survivors with Post-COVID Pain.

Viruses

2022 Jul 7

Fernández-de-Las-Peñas C, Valera-Calero JA, Herrero-Montes M

24. Inducible miR-150 Inhibits Porcine Reproductive and Respiratory Syndrome Virus Replication by Targeting Viral Genome and Suppressor of Cytokine Signaling 1.

Viruses

2022 Jul 7

Li S, Zhang X, Yao Y

25. Characterisation of the RNA Virome of Nine Ochlerotatus Species in Finland.

Viruses

2022 Jul 7

Truong Nguyen PT, Culverwell CL, Suvanto MT

26. Arboviral Infections in Neurological Disorders in Hospitalized Patients in São José do Rio Preto, São Paulo, Brazil.

Viruses

2022 Jul 7

Milhim BHGA, da Rocha LC, Terzian ACB

27. Cellular and Humoral Immune Responses after Immunisation with Low Virulent African Swine Fever Virus in the Large White Inbred Babraham Line and Outbred Domestic Pigs.

Viruses

2022 Jul 7

Goatley LC, Nash RH, Andrews C

28. Insights into Genetic Characteristics and Virological Features of Endemic Avian Influenza A (H9N2) Viruses in Egypt from 2017-2021.

Viruses

2022 Jul 6

El Sayes M, Kandeil A, Moatasim Y

29. Post-Transcriptional Gene Regulation by HPV 16E6 and Its Host Protein Partners.

Viruses

2022 Jul 6

Billingsley CL, Chintala S, Katzenellenbogen RA.

30. Modeling the Impact of Vaccination on COVID-19 and Its Delta and Omicron Variants.

Viruses

2022 Jul 6

Wang J, Chan YC, Niu R

31. Clinical Performance of Rapid and Point-of-Care Antigen Tests for SARS-CoV-2 Variants of Concern: A Living Systematic Review and Meta-Analysis.

Viruses

2022 Jul 6

Kim J, Sung H, Lee H

32. The Divergent Pattern of SARS-CoV-2 Variant Predominance and Transmission Dynamics in the Brazilian Island of Ilhabela.

Viruses

2022 Jul 5

Viala VL, Slavov SN, de Lima LPO

33. HPV16 Induces Formation of Virus-p62-PML Hybrid Bodies to Enable Infection.

Viruses

2022 Jul 5

Schweiger L, Lelieveld-Fast LA, Mikuličić S

34. Phylogenetic Characterisation of the Full Genome of a Bagaza Virus Isolate from Bird Fatalities in South Africa.

Viruses

2022 Jul 5

Mendes A, Lentsoane O, Allam M

35. Vaccine Mismatches, Viral Circulation, and Clinical Severity Patterns of Influenza B Victoria and Yamagata Infections in Brazil over the Decade 2010-2020: A Statistical and Phylogeny-Trait Analyses.

Viruses

2022 Jul 5

Costa JCD, Siqueira MM, Brown D

36. Development of a Novel RT-qPCR Detecting Method of Covert Mortality Nodavirus (CMNV) for the National Proficiency Test in Molecular Detection.

Viruses

2022 Jul 5

Wang W, Liu S, Yao L

37. Implementation of GA-VirReport, a Web-Based Bioinformatics Toolkit for Post-Entry Quarantine Screening of Virus and Viroids in Plants.

Viruses

2022 Jul 5

Lelwala RV, LeBlanc Z, Gauthier MA

38. A New Circular Single-Stranded DNA Virus Related with Howler Monkey Associated Porprismacovirus 1 Detected in Children with Acute Gastroenteritis.

Viruses

2022 Jul 4

Villanova F, Milagres FAP, Brustulin R

39. Virus Infections Play Crucial Roles in the Pathogenesis of Sjögren's Syndrome.

Viruses

2022 Jul 4

Otsuka K, Sato M, Tsunematsu T

40. A Deeper Insight into Evolutionary Patterns and Phylogenetic History of ORF Virus through the Whole Genome Sequencing of the First Italian Strains.

Viruses

2022 Jul 4

Coradduzza E, Sanna D, Scarpa F

41. Alternative Methods to Current In Vivo Procedures to Address the 3Rs Tenet in Rabies Proficiency Testing.

Viruses

2022 Jul 31

Zorzan M, Gourlaouen M, Leopardi S

42. COVID-19 Severity and Mortality in Two Pandemic Waves in Poland and Predictors of Poor Outcomes of SARS-CoV-2 Infection in Hospitalized Young Adults.

Viruses

2022 Jul 31

Ziuzia-Januszewska L, Januszewski M, Sosnowska-Nowak J

43. Role of Genetic Polymorphism Present in Macrophage Activation Syndrome Pathway in Post Mortem Biopsies of Patients with COVID-19.

Viruses

2022 Jul 31

Zanchettin AC, Barbosa LV, Dutra AA

44. Spatially Segregated Transmission of Co-Occluded Baculoviruses Limits Virus-Virus Interactions Mediated by Cellular Coinfection during Primary Infection.

Viruses

2022 Jul 31

Pazmiño-Ibarra V, Herrero S, Sanjuan R.

45. Detection of Equus Caballus Papillomavirus Type-2 in Asymptomatic Italian Horses.

Viruses

2022 Jul 31

Cappelli K, Ciucis CG, Mecocci S

46. The Emergence and Pathogenesis of Recombinant Viruses Associated with NADC34-like Strains and the Predominant Circulating Strains of Porcine Reproductive and Respiratory Syndrome Virus in Southern China.

Viruses

2022 Jul 31

Wang X, Zhang K, Mo Q

Since its recent appearance in China, the NADC30-like strains of porcine reproductive and respiratory syndrome virus 2 (PRRSV-2) have caused an expanding epidemic, and this has further expanded the genetic diversity of PRRSV. In this study, three NADC30-like strains-GXFCG20210401, GXQZ20210403 and GXNN20210506-were isolated from pig serum samples obtained in Guangxi, and their genomes were sequenced. A comparative analysis of the whole genomes showed that the three strains were most similar to NADC30 (88.3-88.7%). In particular, the non-structural protein coding regions (nsp1, nsp4-5, nsp7-8 and nsp9) showed the highest similarities to JXA1, and the ORF2a-ORF5 regions showed the highest similarities to NADC34. The three strains had same discontinuous deletions of 111+1+19 amino acids in the nsp2 region, which were similar to the NADC30-like strains. Phylogenetic tree analysis based on the ORF5 gene showed that the three PRRSV isolates were divided into lineage 1.5 along with the representative NADC34-like strains, but they were classified as NADC30-like strains with respect to the whole genome and nsp2 evolutionary trees. Recombinant analysis revealed complex recombination patterns in the genomes of the three strains, which likely originated from multiple recombination events among JXA1-like, NADC30-like and NADC34-like strains. The results from animal experiments showed that the GXQZ20210403 strain was 20% lethal to piglets and caused more severe clinical reactions than GXFCG20210401, and both recombinant strains were similar in terms of pathogenicity to the previously reported NADC34 strains. This study demonstrates that NADC34-like strains of PRRSV have been circulating in the southern provinces of China and have exchanged genomes with several other indigenous strains. In addition, differences in recombination patterns may cause different clinical pathogenicity and indicate the importance of the surveillance and preventive control of recombinant strains.

47. A Proteomic Approach to Study the Biological Role of Hepatitis C Virus Protein Core+1/ARFP.

Viruses

2022 Jul 31

Vrazas V, Moustafa S, Makridakis M

48. Analysis of Viral and Host Factors on Immunogenicity of 2018, 2019, and 2020 Southern Hemisphere Seasonal Trivalent Inactivated Influenza Vaccine in Adults in Brazil.

Viruses

2022 Jul 30

Capão A, Aguiar-Oliveira ML, Caetano BC

49. HBeAg-Negative/Anti-HBe-Positive Chronic Hepatitis B: A 40-Year-Old History.

Viruses

2022 Jul 30

Bonino F, Colombatto P, Brunetto MR.

50. Glycoprotein Production by Bursal Secretory Dendritic Cells in Normal, Vaccinated, and Infectious Bursal Disease Virus (IBDV)-Infected Chickens.

Viruses

2022 Jul 30

Felföldi B, Benyeda Z, Kovács T

51. Prognostic Value of Mid-Region Proadrenomedullin and In Vitro Interferon Gamma Production for In-Hospital Mortality in Patients with COVID-19 Pneumonia and Respiratory Failure: An Observational Prospective Study.

Viruses

2022 Jul 30

Mangioni D, Oggioni M, Chatenoud L

Coagulopathy and immune dysregulation have been identified as important causes of adverse outcomes in coronavirus disease (COVID-19). Mid-region proadrenomedullin (MR-proADM) is associated with endothelial damage and has recently been proposed as a prognostic factor in COVID-19. In non-COVID-19 immunocompromised patients, low in vitro interferon gamma (IFNγ) production correlates with infection risk and mortality. This prospective, monocentric, observational study included adult patients consecutively admitted with radiologic evidence of COVID-19 pneumonia and respiratory failure. MR-proADM and in vitro IFNγ production were measured at T0 (day 1 from admission) and T1 (day 7 from enrollment). One hundred patients were enrolled. Thirty-six percent were females, median age 65 (Q1-Q3 54.5-75) years, and 58% had ≥1 comorbidity. Only 16 patients had received COVID-19 vaccination before hospitalization. At admission, the median PaO2:FiO2 ratio was 241 (157-309) mmHg. In-hospital mortality was 13%. MR-proADM levels differed significantly between deceased and survivors both at T0 (1.41 (1.12-1.77) nmol/L vs. 0.79 (0.63-1.03) nmol/L, p < 0.001) and T1 (1.67 (1.08-1.96) nmol/L vs. 0.66 (0.53-0.95) nmol/L, p < 0.001). In vitro IFNγ production at T0 and T1 did not vary between groups. When only the subset of non-vaccinated patients was considered, both biomarkers at T1 resulted significantly associated with in-hospital mortality. AUROC for MR-proADM at T0 to predict in-hospital mortality was 0.87 (95%CI 0.79-0.94), with the best cut-off point at 1.04 nmol/L (92% sensitivity, 75% specificity and 98% negative predictive value). In patients with COVID-19 pneumonia and different degrees of respiratory failure, MR-proADM at admission and during hospitalization resulted strongly associated with in-hospital mortality. Low in vitro IFNγ production after the first week of hospitalization was associated with mortality in non-vaccinated patients possibly identifying the subgroup characterized by a higher degree of immune suppression.

52. Serological Investigation and Genetic Characteristics of Pseudorabies Virus between 2019 and 2021 in Henan Province of China.

Viruses

2022 Jul 30

Chen X, Li H, Zhu Q

53. Abundance of Poleroviruses within Tasmanian Pea Crops and Surrounding Weeds, and the Genetic Diversity of TuYV Isolates Found.

Viruses

2022 Jul 30

Umar M, Tegg RS, Farooq T

The genus Polerovirus contains positive-sense, single-stranded RNA plant viruses that cause significant disease in many agricultural crops, including vegetable legumes. This study aimed to identify and determine the abundance of Polerovirus species present within Tasmanian pea crops and surrounding weeds that may act as virus reservoirs. We further sought to examine the genetic diversity of TuYV, the most commonly occurring polerovirus identified. Pea and weed samples were collected during 2019-2020 between October and January from thirty-four sites across three different regions (far northwest, north, and midlands) of Tasmania and tested by RT-PCR assay, with selected samples subject to next-generation sequencing. Results revealed that the presence of polerovirus infection and the prevalence of TuYV in both weeds and pea crops varied across the three Tasmanian cropping regions, with TuYV infection levels in pea crops ranging between 0 and 27.5% of tested plants. Overall, two species members from each genus, Polerovirus and Potyvirus, one member from each of Luteovirus, Potexvirus, and Carlavirus, and an unclassified virus from the family Partitiviridae were also found as a result of NGS data analysis. Analysis of gene sequences of the P0 and P3 genes of Tasmanian TuYV isolates revealed substantial genetic diversity within the collection, with a few isolates appearing more closely aligned with BrYV isolates. Questions remain around the differentiation of TuYV and BrYV species. Phylogenetic inconsistency in the P0 and P3 ORFs supports the concept that recombination may have played a role in TuYV evolution in Tasmania. Results of the evolutionary analysis showed that the selection pressure was higher in the P0 gene than in the P3 gene, and the majority of the codons for each gene are evolving under purifying selection. Future full genome-based analyses of the genetic variations will expand our understanding of the evolutionary patterns existing among TuYV populations in Tasmania.

54. Regulatory T Cells Decreased during Recovery from Mild COVID-19.

Viruses

2022 Jul 30

Seepathomnarong P, Ongarj J, Sophonmanee R

55. Pathogenic Connections in Post-COVID Conditions: What Do We Know in the Large Unknown? A Narrative Review.

Viruses

2022 Jul 30

Stafie CS, Solomon SM, Sufaru IG

56. Progress towards the Development of a Universal Influenza Vaccine.

Viruses

2022 Jul 30

Wang WC, Sayedahmed EE, Sambhara S

57. CIGB-300 Peptide Targets the CK2 Phospho-Acceptor Domain on Human Papillomavirus E7 and Disrupts the Retinoblastoma (RB) Complex in Cervical Cancer Cells.

Viruses

2022 Jul 30

Ramón AC, Basukala O, Massimi P

58. Post-Treatment Neck Dissection of Tonsillar and Base of Tongue Squamous Cell Carcinoma in the Era of PET-CT, HPV, and p16.

Viruses

2022 Jul 30

Landin D, Näsman A, Jara SJ

59. Antiviral Effects of Adipose Tissue-Derived Mesenchymal Stem Cells Secretome against Feline Calicivirus and Feline Herpesvirus Type 1.

Viruses

2022 Jul 30

Teshima T, Yasumura Y, Suzuki R

60. Deletion of the EP296R Gene from the Genome of Highly Virulent African Swine Fever Virus Georgia 2010 Does Not Affect Virus Replication or Virulence in Domestic Pigs.

Viruses

2022 Jul 30

Vuono EA, Ramirez-Medina E, Pruitt S

61. Recombinant Muscovy Duck Parvovirus Led to Ileac Damage in Muscovy Ducklings.

Viruses

2022 Jul 3

He J, Zhang Y, Hu Z

62. Spillover of a Tobamovirus from the Australian Indigenous Flora to Invasive Weeds.

Viruses

2022 Jul 29

Xu W, Li H, Sivasithamparam K

63. Detection of HIV-1 Transmission Clusters from Dried Blood Spots within a Universal Test-and-Treat Trial in East Africa.

Viruses

2022 Jul 29

Pujol-Hodge E, Salazar-Gonzalez JF, Ssemwanga D

64. The Performance of Serum Alpha-Fetoprotein for Detecting Early-Stage Hepatocellular Carcinoma Is Influenced by Antiviral Therapy and Serum Aspartate Aminotransferase: A Study in a Large Cohort of Hepatitis B Virus-Infected Patients.

Viruses

2022 Jul 29

Qian X, Liu Y, Wu F

BACKGROUND AND AIMS: Factors associated with abnormally elevated alpha-fetoprotein (AFP) in hepatitis B virus (HBV)-infected patients remain to be studied. We aimed to identify factors associated with elevated serum AFP in patients with non-hepatocellular carcinoma (HCC) and early-stage HCC and their influences on the performance of AFP for detecting early-stage HCC. METHODS: This multicenter, retrospective study was conducted in 4401 patients with chronic HBV infection, including 3680 patients with non-HCC and 721 patients with early-stage HCC. Factors associated with elevated AFP were analyzed. Diagnostic performance of AFP for early-stage HCC were compared among groups through area under the receiver operating characteristic curve (AUC), sensitivity, and specificity. RESULTS: When analyzed by multivariate logistic regression, antiviral therapy was negatively associated with elevated AFP, while hepatitis B e antigen (HBeAg) and aspartate aminotransferase (AST) > 1× upper limit of normal (ULN) were positively associated with elevated AFP both in patients with non-HCC and early-stage HCC (all p < 0.05). The AUCs of AFP for detecting early-stage HCC in patients with antiviral therapy, HBV DNA (-), alanine aminotransferase (ALT) ≤ 1× ULN, and AST ≤ 1× ULN were significantly higher compared to those in non-antiviral therapy, HBV DNA (+), ALT > 1× ULN, and AST > 1× ULN groups, respectively. When categorizing patients into AST ≤ 1× ULN and > 1× ULN, AFP achieved the highest AUCs in patients with AST ≤ 1× ULN regardless of antiviral treatment (AUCs = 0.813 and 0.806, respectively). Furthermore, there were considerable differences in the cut-off values of AFP in detecting early-stage HCC in different subgroups when applying similar sensitivity and specificity. CONCLUSIONS: Antiviral therapy and serum AST might be used to help judge and select the specific cut-off values of serum AFP for HCC surveillance in different at-risk populations.

65. Functional Analysis of the Cathepsin D Gene Response to SGIV Infection in the Orange-Spotted Grouper, Epinephelus coioides.

Viruses

2022 Jul 29

Wang Y, Han H, Zhu K

66. Evaluation of EPISEQ SARS-CoV-2 and a Fully Integrated Application to Identify SARS-CoV-2 Variants from Several Next-Generation Sequencing Approaches.

Viruses

2022 Jul 29

Mugnier N, Griffon A, Simon B

Viruses

2022 Jul 29

Patil SS, Catanese HN, Brayton KA

68. Identifying HIV-1 Transmission Clusters in Uzbekistan through Analysis of Molecular Surveillance Data.

Viruses

2022 Jul 29

Lebedev A, Kuznetsova A, Kim K

69. Differentiation between Wild-Type Group A Rotaviruses and Vaccine Strains in Cases of Suspected Horizontal Transmission and Adverse Events Following Vaccination.

Viruses

2022 Jul 29

Jacobsen S, Niendorf S, Lorenz R

Human group A rotaviruses (RVA) are important enteric pathogens, as they are a leading cause of acute gastroenteritis (AGE) in children worldwide. Since 2013, the German Standing Committee on vaccination recommended the routine rotavirus vaccination for infants in Germany. While vaccination has significantly decreased RVA cases and worldwide mortality, in some cases, infants can develop acute gastroenteritis as an adverse reaction after immunization with an attenuated live vaccine. Pediatricians, as well as clinicians and diagnostic laboratories, contacted the Consultant Laboratory for Rotaviruses and inquired whether cases of RVA-positive AGE after vaccination were associated with vaccine or with wild-type RVA strains. A testing algorithm based on distinguishing PCRs and confirmative sequencing was designed, tested, and applied. Diagnostic samples from 68 vaccinated children and six cases where horizontal transmission was suspected were investigated in this study. Using a combination of real-time PCR, fragment-length analysis of amplicons from multiplex PCRs and confirmative sequencing, vaccine-like virus was detected in 46 samples and wild-type RVA was detected in 6 samples. Three mixed infections of vaccine and wild-type RVA were detectable, no RVA genome was found in 19 samples. High viral loads (>1.0 × 107 copies/g stool) were measured in most RVA-positive samples. Furthermore, information on co-infections with other AGE pathogens in the vaccinated study population was of interest. A commercial multiplex PCR and in-house PCRs revealed three co-infections of vaccinated infants with bacteria (two samples with Clostridioides difficile and one sample with enteropathogenic E. coli) and six co-infections with norovirus in a subset of the samples. Human astrovirus was detected in one sample, with suspected horizontal transmission. The cases of suspected horizontal transmission of vaccine RVA strains could not be confirmed, as they either involved wild-type RVA or were RVA negative. This study shows that RVA-positive AGE after vaccination is not necessarily associated with the vaccine strain and provides a reliable workflow to distinguish RVA vaccine strains from wild-type strains.

70. Bunyaviral N Proteins Localize at RNA Processing Bodies and Stress Granules: The Enigma of Cytoplasmic Sources of Capped RNA for Cap Snatching.

Viruses

2022 Jul 29

Xu M, Mazur M, Gulickx N

71. Characterisation of a Hepatitis C Virus Subtype 2a Cluster in Scottish PWID with a Suboptimal Response to Glecaprevir/Pibrentasvir Treatment.

Viruses

2022 Jul 29

Shah R, Barclay ST, Peters ES

72. Changes in Body Mass Index after Initiation of Antiretroviral Treatment: Differences by Class of Core Drug.

Viruses

2022 Jul 29

Pantazis N, Papastamopoulos V, Antoniadou A

73. Detection of Feline Coronavirus Variants in Cats without Feline Infectious Peritonitis.

Viruses

2022 Jul 29

Jähne S, Felten S, Bergmann M

74. Finding Asymptomatic Spreaders in a COVID-19 Transmission Network by Graph Attention Networks.

Viruses

2022 Jul 28

Liu Z, Ma Y, Cheng Q

75. Serum SARS-CoV-2 Antigens for the Determination of COVID-19 Severity.

Viruses

2022 Jul 28

Favresse J, Bayart JL, David C

76. Susceptibility of Type I Interferon Receptor Knock-Out Mice to Heartland Bandavirus (HRTV) Infection and Efficacy of Favipiravir and Ribavirin in the Treatment of the Mice Infected with HRTV.

Viruses

2022 Jul 28

Fujii H, Tani H, Egawa K

77. Novel Coronavirus and Common Pneumonia Detection from CT Scans Using Deep Learning-Based Extracted Features.

Viruses

2022 Jul 28

Latif G, Morsy H, Hassan A

COVID-19 which was announced as a pandemic on 11 March 2020, is still infecting millions to date as the vaccines that have been developed do not prevent the disease but rather reduce the severity of the symptoms. Until a vaccine is developed that can prevent COVID-19 infection, the testing of individuals will be a continuous process. Medical personnel monitor and treat all health conditions; hence, the time-consuming process to monitor and test all individuals for COVID-19 becomes an impossible task, especially as COVID-19 shares similar symptoms with the common cold and pneumonia. Some off-the-counter tests have been developed and sold, but they are unreliable and add an additional burden because false-positive cases have to visit hospitals and perform specialized diagnostic tests to confirm the diagnosis. Therefore, the need for systems that can automatically detect and diagnose COVID-19 automatically without human intervention is still an urgent priority and will remain so because the same technology can be used for future pandemics and other health conditions. In this paper, we propose a modified machine learning (ML) process that integrates deep learning (DL) algorithms for feature extraction and well-known classifiers that can accurately detect and diagnose COVID-19 from chest CT scans. Publicly available datasets were made available by the China Consortium for Chest CT Image Investigation (CC-CCII). The highest average accuracy obtained was 99.9% using the modified ML process when 2000 features were extracted using GoogleNet and ResNet18 and using the support vector machine (SVM) classifier. The results obtained using the modified ML process were higher when compared to similar methods reported in the extant literature using the same datasets or different datasets of similar size; thus, this study is considered of added value to the current body of knowledge. Further research in this field is required to develop methods that can be applied in hospitals and can better equip mankind to be prepared for any future pandemics.

78. GEM-PA-Based Subunit Vaccines of Crimean Congo Hemorrhagic Fever Induces Systemic Immune Responses in Mice.

Viruses

2022 Jul 28

Wang Q, Wang S, Shi Z

The Crimean Congo Hemorrhagic Fever Virus (CCHFV) is a tick-borne bunyavirus of the Narovirus genus, which is the causative agent of Crimean Congo Hemorrhagic Fever (CCHF). CCHF is endemic in Africa, the Middle East, Eastern Europe and Asia, with a high case-fatality rate of up to 50% in humans. Currently, there are no approved vaccines or effective therapies available for CCHF. The GEM-PA is a safe, versatile and effective carrier system, which offers a cost-efficient, high-throughput platform for recovery and purification of subunit proteins for vaccines. In the present study, based on a GEM-PA surface display system, a GEM-PA based vaccine expressing three subunit vaccine candidates (G-GP, including G-eGN, G-eGC and G-NAb) of CCHFV was developed, displaying the ectodomains of the structural glycoproteins eGN, eGC and NAb, respectively. According to the immunological assays including indirect-ELISA, a micro-neutralization test of pseudo-virus and ELISpot, 5 μg GPBLP3 combined with Montanide ISA 201VG plus Poly (I:C) adjuvant (A-G-GP-5 μg) elicited GP-specific humoral and cellular immunity in BALB/c mice after three vaccinations via subcutaneous injection (s.c.). The consistent data between IgG subtype and cytokine detection, ELISpot and cytokine detection indicated balanced Th1 and Th2 responses, of which G-eGN vaccines could elicit a stronger T-cell response post-vaccination, respectively. Moreover, all three vaccine candidates elicited high TNF-α, IL-6, and IL-10 cytokine levels in the supernatant of stimulated splenocytes in vitro. However, the neutralizing antibody (nAb) was only detected in A-G-eGC and A-G-eGC vaccination groups with the highest neutralizing titer of 128, suggesting that G-eGC could elicit a stronger humoral immune response. In conclusion, the GEM-PA surface display system could provide an efficient and convenient purification method for CCHFV subunit antigens, and the G-GP subunit vaccine candidates will be promising against CCHFV infections with excellent immunogenicity.

79. The Virus-Induced Upregulation of the miR-183/96/182 Cluster and the FoxO Family Protein Members Are Not Required for Efficient Replication of HSV-1.

Viruses

2022 Jul 28

Zubković A, Žarak I, Ratkaj I

80. The Impact of Epitranscriptomics on Antiviral Innate Immunity.

Viruses

2022 Jul 28

Mersinoglu B, Cristinelli S, Ciuffi A.

81. Results of a European-Wide External Quality Assessment (EQA) Scheme for Serological Detection of Anti-SARS-CoV-2 (CoVimm)-Pitfalls of Routine Application.

Viruses

2022 Jul 28

Kittel M, Eichner R, Aida S

BACKGROUND: During the last two years, a variety of assays for the serological detection of antibodies to the new SARS-CoV-2 virus have been launched and used as part of standard care in many laboratories. The pace with which these tests have been introduced into routine care emphasizes the importance of quality measures for analytical methods, particularly with regard to the implications of results for clinical and epidemiologic decisions. Accuracy, reliability and comparability of analytical test results are thus essential, and here external quality assessment (EQA) is the most important quality assurance tool. It allows us to achieve harmonization of test methods as a prerequisite for a high standard of performance for laboratory and analytical techniques and their interpretation. METHODS: This EQA scheme consisted of pre-characterized clinical biospecimens dedicated to the analysis of anti-SARS-CoV-2 IgG total antibodies and differentiation into spike protein-specific IgG antibodies against SARS-CoV-2 (anti-S-SARS-CoV-2) and nucleocapsid-specific IgG antibodies against SARS-CoV-2 (anti-N-SARS-CoV-2). RESULTS: A total of 239 laboratories across Europe participated in this scheme, called CoVimm. In detail, 536 results for anti-SARS-CoV-2 IgG, 431 results for anti-S-SARS-CoV-2 IgG, and 200 results for anti-N-SARS-CoV-2 IgG were reported. Based on the pre-defined thresholds, the success rates for the determination of anti-S-SARS-CoV-2 IgG and anti-N-SARS-CoV-2 IgG were 96% and 90%, respectively. Interestingly, only 64% of the participating laboratories successfully passed the EQA scheme for the determination of total anti-SARS-CoV-2 IgG. CONCLUSIONS: This EQA revealed serious concerns regarding the reliability and appropriate use of anti-SARS-CoV-2 antibody assays in routine care. In addition to the wide heterogeneity of different assays used by participating laboratories, a lack of standardization and harmonization is also evident. This is of particular importance for reliable and clinically meaningful interpretation of test results.

82. Neutralizing mAbs against SFTS Virus Gn Protein Show Strong Therapeutic Effects in an SFTS Animal Model.

Viruses

2022 Jul 28

Shimojima M, Sugimoto S, Umekita K

83. Detection of Nipah and Hendra Viruses Using Recombinant Human Ephrin B2 Capture Virus in Immunoassays.

Viruses

2022 Jul 28

Yang M, Zhu W, Truong T

84. Harnessing Human Papillomavirus' Natural Tropism to Target Tumors.

Viruses

2022 Jul 28

Kines RC, Schiller JT.

85. Special Issue "Replication and Spread of Alphaherpesviruses".

Viruses

2022 Jul 28

Rice SA.

86. SARS-CoV-2 Infection in Health Care Workers of Trieste (North-Eastern Italy), 1 October 2020-7 February 2022: Occupational Risk and the Impact of the Omicron Variant.

Viruses

2022 Jul 28

Cegolon L, Ronchese F, Ricci F

87. Molecular Epidemiology of HIV-1 among Prisoners in Central Brazil and Evidence of Transmission Clusters.

Viruses

2022 Jul 28

Tanaka TSO, Cesar GA, Rezende GR

88. Adapting an Atmospheric Dispersion Model to Assess the Risk of Windborne Transmission of Porcine Reproductive and Respiratory Syndrome Virus between Swine Farms.

Viruses

2022 Jul 28

Kanankege KST, Graham K, Corzo CA

89. A Human and Rhesus Macaque Interferon-Stimulated Gene Screen Shows That Over-Expression of ARHGEF3/XPLN Inhibits Replication of Hepatitis C Virus and Other Flavivirids.

Viruses

2022 Jul 28

Bamford CGG, Aranday-Cortes E, Sanchez-Velazquez R

90. Characterization of Pipistrellus pygmaeus Bat Virome from Sweden.

Viruses

2022 Jul 28

Cholleti H, de Jong J, Blomström AL

91. Mapping and Validation of Peptides Differentially Recognized by Antibodies from the Serum of Yellow Fever Virus-Infected or 17DD-Vaccinated Patients.

Viruses

2022 Jul 27

Oliveira ES, Tavares NC, Colombarolli SG

92. Six-Month Follow-Up of Immune Responses after a Rapid Mass Vaccination against SARS-CoV-2 with BNT162b2 in the District of Schwaz/Austria.

Viruses

2022 Jul 27

Bánki Z, Seekircher L, Falkensammer B

93. The Role of Lebanon in the COVID-19 Butterfly Effect: The B.1.398 Example.

Viruses

2022 Jul 27

Nour D, Rafei R, Lamarca AP

94. Pseudorabies Virus: From Pathogenesis to Prevention Strategies.

Viruses

2022 Jul 27

Zheng HH, Fu PF, Chen HY

95. Synthesis, Assembly and Processing of Viral Proteins.

Viruses

2022 Jul 27

Wang WH, Thitithanyanont A, Wang SF.

96. Characterization of a Human Sapovirus Genotype GII.3 Strain Generated by a Reverse Genetics System: VP2 Is a Minor Structural Protein of the Virion.

Viruses

2022 Jul 27

Li TC, Kataoka M, Doan YH

97. Robust Phylodynamic Analysis of Genetic Sequencing Data from Structured Populations.

Viruses

2022 Jul 27

Scire J, Barido-Sottani J, Kühnert D

98. Myocardial Infarction Following COVID-19 Vaccine Administration: Post Hoc, Ergo Propter Hoc?

Viruses

2022 Jul 27

Baronti A, Gentile F, Manetti AC

99. Ivermectin Inhibits the Replication of Usutu Virus In Vitro.

Viruses

2022 Jul 27

Wald ME, Claus C, Konrath A

100. Beyond Amyloid Fibers: Accumulation, Biological Relevance, and Regulation of Higher-Order Prion Architectures.

Viruses

2022 Jul 27

Naeimi WR, Serio TR.

101. Pathogenicity and Pathotype Analysis of Henan Isolates of Marek's Disease Virus Reveal Long-Term Circulation of Highly Virulent MDV Variant in China.

Viruses

2022 Jul 27

Teng M, Zheng LP, Li HZ

102. Comparative Genomics of Closely-Related Gordonia Cluster DR Bacteriophages.

Viruses

2022 Jul 27

Versoza CJ, Howell AA, Aftab T

103. Vaccination, Risk Factors and Outcomes of COVID-19 Infection in Patients with Psoriasis-A Single Centre Real-Life Experience from Eastern Slovakia.

Viruses

2022 Jul 27

Baloghová J, Kampe T, Kolarčik P

104. Simultaneous Isolation and Identification of Largemouth Bass Virus and Rhabdovirus from Moribund Largemouth Bass (Micropterus salmoides).

Viruses

2022 Jul 27

Jin Y, Bergmann SM, Mai Q

105. Adenovirus 36 Infection in People Living with HIV-An Epidemiological Study of Seroprevalence and Associations with Cardiovascular Risk Factors.

Viruses

2022 Jul 27

Sapuła M, Suchacz M, Kozłowska J

106. Collaborative Referral Model to Achieve Hepatitis C Micro-Elimination in Methadone Maintenance Treatment Patients during the COVID-19 Pandemic.

Viruses

2022 Jul 27

Tai CM, Huang CK, Changchien TC

107. SERINC5-Mediated Restriction of HIV-1 Infectivity Correlates with Resistance to Cholesterol Extraction but Not with Lipid Order of Viral Membrane.

Viruses

2022 Jul 27

Raghunath G, Chen YC, Marin M

108. Systemic Autoimmune Diseases in Patients Hospitalized with COVID-19 in Spain: A Nation-Wide Registry Study.

Viruses

2022 Jul 26

Moreno-Torres V, Mendoza C, Mellor-Pita S

109. Influenza Viruses Suitable for Studies in Syrian Hamsters.

Viruses

2022 Jul 26

Fan S, Gu C, Kong H

110. Cross-Species Analysis of Innate Immune Antagonism by Cytomegalovirus IE1 Protein.

Viruses

2022 Jul 26

Rothemund F, Scherer M, Schilling EM

The human cytomegalovirus (CMV) immediate early 1 (IE1) protein has evolved as a multifunctional antagonist of intrinsic and innate immune mechanisms. In addition, this protein serves as a transactivator and potential genome maintenance protein. Recently, the crystal structures of the human and rat CMV IE1 (hIE1, rIE1) core domain were solved. Despite low sequence identity, the respective structures display a highly similar, all alpha-helical fold with distinct variations. To elucidate which activities of IE1 are either species-specific or conserved, this study aimed at a comparative analysis of hIE1 and rIE1 functions. To facilitate the quantitative evaluation of interactions between IE1 and cellular proteins, a sensitive NanoBRET assay was established. This confirmed the species-specific interaction of IE1 with the cellular restriction factor promyelocytic leukemia protein (PML) and with the DNA replication factor flap endonuclease 1 (FEN1). To characterize the respective binding surfaces, helix exchange mutants were generated by swapping hIE1 helices with the corresponding rIE1 helices. Interestingly, while all mutants were defective for PML binding, loss of FEN1 interaction was confined to the exchange of helices 1 and 2, suggesting that FEN1 binds to the stalk region of IE1. Furthermore, our data reveal that both hIE1 and rIE1 antagonize human STAT2; however, distinct regions of the respective viral proteins mediated the interaction. Finally, while PML, FEN1, and STAT2 binding were conserved between primate and rodent proteins, we detected that rIE1 lacks a chromatin tethering function suggesting that this activity is dispensable for rat CMV. In conclusion, our study revealed conserved and distinct functions of primate and rodent IE1 proteins, further supporting the concept that IE1 proteins underwent a narrow co-evolution with their respective hosts to maximize their efficacy in antagonizing innate immune mechanisms and supporting viral replication.

111. Performance of Cardiotropic rAAV Vectors Is Dependent on Production Method.

Viruses

2022 Jul 26

Rao R, Farraha M, Logan GJ

112. Evolutionary Dynamics of Foot and Mouth Disease Virus Serotype A and Its Endemic Sub-Lineage A/ASIA/Iran-05/SIS-13 in Pakistan.

Viruses

2022 Jul 26

Naqvi SS, Bostan N, Fukai K

113. Immunobiological Characteristics of the Attenuated African Swine Fever Virus Strain Katanga-350.

Viruses

2022 Jul 26

Sereda AD, Vlasov ME, Koltsova GS

114. Generation of a Soluble African Horse Sickness Virus VP7 Protein Capable of Forming Core-like Particles.

Viruses

2022 Jul 26

Bekker S, Huismans H, van Staden V.

115. Correction: Netto et al. Hypovitaminosis D Is Associated with Higher Levels of Inflammatory Cytokines and with HAM/TSP in HTLV-Infected Patients. Viruses 2021, 13, 2223.

Viruses

2022 Jul 26

Netto EC, Silva AC, Pedroso C

116. Matrix Metalloproteinases Expression Is Associated with SARS-CoV-2-Induced Lung Pathology and Extracellular-Matrix Remodeling in K18-hACE2 Mice.

Viruses

2022 Jul 26

Gutman H, Aftalion M, Melamed S

117. Mechanistic Interplay between HIV-1 Reverse Transcriptase Enzyme Kinetics and Host SAMHD1 Protein: Viral Myeloid-Cell Tropism and Genomic Mutagenesis.

Viruses

2022 Jul 26

Bowen NE, Oo A, Kim B.

118. Impact of HIV-1 Infection on the Natural Progress of an Anti-HCV Positive Population in an Impoverished Village in China from 2009 to 2017.

Viruses

2022 Jul 26

Li X, Li Y, Zhang Y

119. Efficacy of Topically Administered Dihydroartemisinin in Treating Papillomavirus-Induced Anogenital Dysplasia in Preclinical Mouse Models.

Viruses

2022 Jul 26

Gunder LC, Blaine-Sauer S, Johnson HR

120. Inhibition of Venezuelan Equine Encephalitis Virus Using Small Interfering RNAs.

Viruses

2022 Jul 26

Haikerwal A, Barrera MD, Bhalla N

121. Identification of Critical Genes and Pathways for Influenza A Virus Infections via Bioinformatics Analysis.

Viruses

2022 Jul 26

Chen G, Li H, Hao M

122. Detection of African Swine Fever Virus in Ornithodoros Tick Species Associated with Indigenous and Extralimital Warthog Populations in South Africa.

Viruses

2022 Jul 26

Craig AF, Schade-Weskott ML, Rametse T

We investigated the possibility that sylvatic circulation of African swine fever virus (ASFV) in warthogs and Ornithodoros ticks had extended beyond the historically affected northern part of South Africa that was declared a controlled area in 1935 to prevent the spread of infection to the rest of the country. We recently reported finding antibody to the virus in extralimital warthogs in the south of the country, and now describe the detection of infected ticks outside the controlled area. A total of 5078 ticks was collected at 45 locations in 7/9 provinces during 2019-2021 and assayed as 711 pools for virus content by qPCR, while 221 pools were also analysed for tick phylogenetics. Viral nucleic acid was detected in 50 tick pools representing all four members of the Ornithodoros (Ornithodoros) moubata complex known to occur in South Africa: O. (O.) waterbergensis and O. (O.) phacochoerus species yielded ASFV genotypes XX, XXI, XXII at 4 locations and O. (O.) moubata yielded ASFV genotype I at two locations inside the controlled area. Outside the controlled area, O. (O.) moubata and O. (O.) compactus ticks yielded ASFV genotype I at 7 locations, while genotype III ASFV was identified in O. (O.) compactus ticks at a single location. Two of the three species of the O. (O.) savignyi complex ticks known to be present in the country, O. (O.) kalahariensis and O. (O.) noorsveldensis, were collected at single locations and found negative for virus. The only member of the Pavlovskyella subgenus of Ornithodoros ticks known to occur in South Africa, O. (P.) zumpti, was collected from warthog burrows for the first time, in Addo National Park in the Eastern Cape Province where ASFV had never been recorded, and it tested negative for the viral nucleic acid. While it is confirmed that there is sylvatic circulation of ASFV outside the controlled area in South Africa, there is a need for more extensive surveillance and for vector competence studies with various species of Ornithodoros ticks.

123. Usutu Virus Infects Human Placental Explants and Induces Congenital Defects in Mice.

Viruses

2022 Jul 25

Martin H, Barthelemy J, Chin Y

124. Virulent Phages Isolated from a Smear-Ripened Cheese Are Also Detected in Reservoirs of the Cheese Factory.

Viruses

2022 Jul 25

Paillet T, Lossouarn J, Figueroa C

125. Recombinant Bovine Herpesvirus Type I Expressing the Bovine Viral Diarrhea Virus E2 Protein Could Effectively Prevent Infection by Two Viruses.

Viruses

2022 Jul 25

Liu CY, Guo H, Zhao HZ

126. Intergrated Transcriptomic and Proteomic Analysis Revealed the Differential Responses to Novel Duck Reovirus Infection in the Bursa of Fabricius of Cairna moschata.

Viruses

2022 Jul 25

Yun T, Hua J, Ye W

127. BK Virus Nephropathy in Kidney Transplantation: A State-of-the-Art Review.

Viruses

2022 Jul 25

Kant S, Dasgupta A, Bagnasco S

128. Prevalence and Predictors of Liver Fibrosis in People Living with Hepatitis B in Senegal.

Viruses

2022 Jul 24

Ramírez Mena A, Ngom NF, Tine J

129. The Effect of Treatment-Induced Viral Eradication on Cytokine and Growth Factor Expression in Chronic Hepatitis C.

Viruses

2022 Jul 24

Radmanić L, Bodulić K, Šimičić P

130. TRIM7 Restricts Coxsackievirus and Norovirus Infection by Detecting the C-Terminal Glutamine Generated by 3C Protease Processing.

Viruses

2022 Jul 23

Luptak J, Mallery DL, Jahun AS

131. Characterization and Genomic Analysis of Novel Vibrio parahaemolyticus Phage vB_VpaP_DE10.

Viruses

2022 Jul 23

Ye Y, Chen H, Huang Q

132. Genomic Diversity of Torque Teno Virus in Blood Samples from Febrile Paediatric Outpatients in Tanzania: A Descriptive Cohort Study.

Viruses

2022 Jul 23

Laubscher F, Hartley MA, Kaiser L

133. Is the HTLV-1 Retrovirus Targeted by Host Restriction Factors?

Viruses

2022 Jul 23

Carcone A, Journo C, Dutartre H.

134. Nasal Mucosa Exploited by SARS-CoV-2 for Replicating and Shedding during Reinfection.

Viruses

2022 Jul 23

Li H, Zhao X, Li J

135. Clinical Aspects of the Subsequent SARS-CoV-2 Waves in Children from 2020 to 2022-Data from a Local Cohort in Cologne, Germany (n = 21,635).

Viruses

2022 Jul 23

Meyer M, Ruebsteck E, Dewald F

136. Silent Infection of Highly Pathogenic Avian Influenza Virus (H5N1) Clade 2.3.4.4b in a Commercial Chicken Broiler Flock in Italy.

Viruses

2022 Jul 22

Gobbo F, Zanardello C, Bottinelli M

137. Immune Escape Associated with RBD Omicron Mutations and SARS-CoV-2 Evolution Dynamics.

Viruses

2022 Jul 22

Kudriavtsev AV, Vakhrusheva AV, Novosеletsky VN

138. Vaccination and Antibody Testing in Cats.

Viruses

2022 Jul 22

Egberink H, Frymus T, Hartmann K

139. Quantitative and Qualitative Changes in the Deformed Wing Virus Population in Honey Bees Associated with the Introduction or Removal of Varroa destructor.

Viruses

2022 Jul 22

Woodford L, Christie CR, Campbell EM

140. Glucose Reduces Norovirus Binding to Enterobacter cloacae and Alters Gene Expression of Bacterial Surface Structures in a Growth Phase Dependent Manner.

Viruses

2022 Jul 22

Long KJ, Mosby CA, Jones MK.

Norovirus is the leading cause of acute viral gastroenteritis. Both human and murine noroviruses attach to commensal bacteria belonging to the mammalian gut flora, and binding levels are influenced by nutrients present in bacterial media. However, it is not known which nutrients are responsible for altering viral binding or why binding is altered. Gene expression of commensal bacteria can be changed by the external environment as well as by interaction with pathogens. For example, growth phase and incubation conditions impact expression levels of specific bacterial genes in Escherichia coli. We have previously shown that binding by both human and murine noroviruses to the commensal bacterium Enterobacter cloacae induces genome-wide changes in gene expression with a large number of differentially expressed genes associated with the surface structure of the bacterial cell. The current study evaluated norovirus binding under nutrient-limited conditions and assessed the expression of a select panel of these genes that are significantly altered by norovirus binding under these conditions. The goal of this work was to determine how norovirus attachment to Enterobacter cloacae affected the expression of these genes under varying nutrient and growth phase conditions. We found that the presence of glucose in minimal media reduced murine norovirus binding to E. cloacae and viral binding in the presence of glucose reduced gene expression for surface structures previously associated with norovirus attachment. Changes in viral binding and gene expression occurred in a growth phase-dependent manner. Collectively, these data demonstrate that both the growth phase and nutrient availability alter viral interactions with commensal bacteria and the subsequent changes in gene expression. Ultimately, this work advances our understanding of norovirus-bacterium interactions and provides a foundation for elucidating the conditions and surface structures that regulate norovirus attachment to bacteria.

141. Fixed-Dose Ultrasound-Assisted Catheter-Directed Thrombolysis for Acute Pulmonary Embolism Associated with COVID-19.

Viruses

2022 Jul 22

Voci D, Zbinden S, Micieli E

Background. Fixed-dose ultrasound-assisted catheter-directed thrombolysis (USAT) rapidly improves hemodynamic parameters and reverses right ventricular dysfunction caused by acute pulmonary embolism (PE). The effectiveness of USAT for acute PE associated with coronavirus disease 2019 (COVID-19) is unknown. Methods and results. The study population of this cohort study consisted of 36 patients with an intermediate-high- or high-risk acute PE treated with a fixed low-dose USAT protocol (r-tPA 10-20 mg/15 h). Of these, 9 patients tested positive for COVID-19 and were age-sex-matched to 27 patients without COVID-19. The USAT protocol included, beyond the infusion of recombinant tissue plasminogen activator, anti-Xa-activity-adjusted unfractionated heparin therapy (target 0.3-0.7 U/mL). The study outcomes were the invasively measured mean pulmonary arterial pressure (mPAP) before and at completion of USAT, and the National Early Warning Score (NEWS), according to which more points indicate more severe hemodynamic impairment. Twenty-four (66.7%) patients were men; the mean age was 67 ± 14 years. Mean &nbsp;± &nbsp;standard deviation mPAP decreased from 32.3 ± 8.3 to 22.4 ± 7.0 mmHg among COVID-19 patients and from 35.4 ± 9.7 to 24.6 ± 7.0 mmHg among unexposed, with no difference in the relative improvement between groups (p = 0.84). Within 12 h of USAT start, the median NEWS decreased from six (Q1-Q3: 4-8) to three (Q1-Q3: 2-4) points among COVID-19 patients and from four (Q1-Q3: 2-6) to two (Q1-Q3: 2-3) points among unexposed (p = 0.29). One COVID-19 patient died due to COVID-19-related complications 14 days after acute PE. No major bleeding events occurred. Conclusions. Among patients with COVID-19-associated acute PE, mPAP rapidly decreased during USAT with a concomitant progressive improvement of the NEWS. The magnitude of mPAP reduction was similar in patients with and without COVID-19.

142. A Hierarchical Framework for Assessing Transmission Causality of Respiratory Viruses.

Viruses

2022 Jul 22

Jefferson T, Heneghan CJ, Spencer E

143. Isolation and Characterization of a Lytic Vibrio parahaemolyticus Phage vB_VpaP_GHSM17 from Sewage Samples.

Viruses

2022 Jul 22

Liang X, Wang Y, Hong B

144. History of the Wastewater Assessment of Polio and Non-Polio Enteroviruses in the Slovak Republic in 1963-2019.

Viruses

2022 Jul 22

Kissova R, Pastuchova K, Lengyelova V

145. A Novel Iridovirus Discovered in Deep-Sea Carnivorous Sponges.

Viruses

2022 Jul 22

Canuti M, Large G, Verhoeven JTP

146. African Swine Fever Virus Manipulates the Cell Cycle of G0-Infected Cells to Access Cellular Nucleotides.

Viruses

2022 Jul 22

Avagyan HR, Hakobyan SA, Poghosyan AA

147. Gamma-Delta T-Cell Phenotype and Function in DAA-Treated HIV-HCV Co-Infected and HCV-Mono-Infected Subjects.

Viruses

2022 Jul 22

Bono V, Tincati C, Van Den Bogaart L

148. Dynamics of the Emerging Genogroup of Infectious Bursal Disease Virus Infection in Broiler Farms in South Korea: A Nationwide Study.

Viruses

2022 Jul 22

Thai TN, Yoo DS, Jang I

149. Morphological and Genetic Characterization of Eggerthella lenta Bacteriophage PMBT5.

Viruses

2022 Jul 22

Sprotte S, Rasmussen TS, Cho GS

150. Influenza A Virus Infection Reactivates Human Endogenous Retroviruses Associated with Modulation of Antiviral Immunity.

Viruses

2022 Jul 21

Liu H, Bergant V, Frishman G

151. Implications of the Actin Cytoskeleton on the Multi-Step Process of [PSI(+)] Prion Formation.

Viruses

2022 Jul 21

Dorweiler JE, Lyke DR, Lemoine NP

152. Infection with Borrelia burgdorferi Increases the Replication and Dissemination of Coinfecting Powassan Virus in Ixodes scapularis Ticks.

Viruses

2022 Jul 21

Hart CE, Middleton FA, Thangamani S.

153. SARS-CoV-2 Omicron Induces Enhanced Mucosal Interferon Response Compared to other Variants of Concern, Associated with Restricted Replication in Human Lung Tissues.

Viruses

2022 Jul 21

Alfi O, Hamdan M, Wald O

154. Detection of Gyrovirus galga 1 in Cryopreserved Organs from Two Commercial Broiler Flocks in Japan.

Viruses

2022 Jul 21

Mase M, Yamamoto Y, Iseki H

155. Evaluation of the HIV-1 Polymerase Gene Sequence Diversity for Prediction of Recent HIV-1 Infections Using Shannon Entropy Analysis.

Viruses

2022 Jul 21

Nkone P, Loubser S, Quinn TC

156. Effect of the Interaction between Viral PB2 and Host SphK1 on H9N2 AIV Replication in Mammals.

Viruses

2022 Jul 21

Zhou Y, Gao W, Sun Y

157. Identification of a Virulent Newcastle Disease Virus Strain Isolated from Pigeons (Columbia livia) in Northeastern Brazil Using Next-Generation Genome Sequencing.

Viruses

2022 Jul 21

Pereira MR, Machado LC, de Oliveira Carvalho RD

158. Network Pharmacology and Molecular Docking Elucidate the Underlying Pharmacological Mechanisms of the Herb Houttuynia cordata in Treating Pneumonia Caused by SARS-CoV-2.

Viruses

2022 Jul 21

Liu J, Yuan S, Yao Y

159. Evidence of Maternal Antibodies Elicited by COVID-19 Vaccination in Amniotic Fluid: Report of Two Cases in Italy.

Viruses

2022 Jul 21

Colavita F, Oliva A, Bettini A

160. Into the Dark: Exploring the Deep Ocean with Single-Virus Genomics.

Viruses

2022 Jul 21

Martinez-Hernandez F, Fornas O, Martinez-Garcia M.

161. Manipulation of the Host Cytoskeleton by Viruses: Insights and Mechanisms.

Viruses

2022 Jul 21

Seo D, Gammon DB.

162. Comparative Transcriptome Analysis of CMV or 2b-Deficient CMV-Infected dcl2dcl4 Reveals the Effects of Viral Infection on Symptom Induction in Arabidopsis thaliana.

Viruses

2022 Jul 21

Xu Q, Shen L, Jin L

163. Histopathological and Immunological Findings in the Common Marmoset Following Exposure to Aerosolized SARS-CoV-2.

Viruses

2022 Jul 21

Ireland RE, Davies CD, Keyser E

164. Epidemiology of Mosquito-Borne Viruses in Egypt: A Systematic Review.

Viruses

2022 Jul 20

Fang Y, Khater EIM, Xue JB

165. Transmission of Raccoon-Passaged Chronic Wasting Disease Agent to White-Tailed Deer.

Viruses

2022 Jul 20

Cassmann ED, Frese AJ, Moore SJ

166. EpiRegress: A Method to Estimate and Predict the Time-Varying Effective Reproduction Number.

Viruses

2022 Jul 20

Jin S, Dickens BL, Lim JT

167. SARS-CoV-2 Specific Immune Response and Inflammatory Profile in Advanced HIV-Infected Persons during a COVID-19 Outbreak.

Viruses

2022 Jul 20

Vergori A, Boschini A, Notari S

168. Is the Glycoprotein Responsible for the Differences in Dispersal Rates between Lettuce Necrotic Yellows Virus Subgroups?

Viruses

2022 Jul 20

Prabowo EY, Valmonte-Cortes GR, Darling TL

169. Kathryn V. Holmes: A Career of Contributions to the Coronavirus Field.

Viruses

2022 Jul 20

Bonavia A, Dominguez SR, Dveksler G

170. A Reverse Mutation E143K within the PrM Protein of Zika Virus Asian Lineage Natal RGN Strain Increases Infectivity and Cytopathicity.

Viruses

2022 Jul 20

Lin CS, Li WJ, Liao CY

Zika virus (ZIKV) is a positive-sense single-stranded RNA virus in the Flaviviridae, which is classified into two different lineages Asian and African. The outbreak of ZIKV Asian lineage isolates in 2015-2016 is associated with the increase in cases with prenatal microcephaly and Guillain-Barré syndrome, and has sparked attention throughout the world. Genome sequence alignment and the analysis of Asian and African lineage isolates indicate that amino acid changes, particular in positively charged amino acid substitutions in the pr region of prM protein might involve a phenotypic change that links with the global outbreak of ZIKV Asian-lineage. The study generated and characterized the virological properties of wild type and mutants of single-round infectious particles (SRIPs) and infectious clones (i.c.s) of ZIKV Asian-lineage Natal RGN strain, and then identified the function of amino acid substitutions at the positions 139 [Asn139→Ser139 (N139S)] and 143 [Glu143→Lys143 (E143K)] in ZIKV polyproteins (located within the pr region of prM protein) in the infectivity and cytopathogenicity. The E143K SRIP and i.c. of Natal RGN strain exhibited relatively higher levels of cytopathic effect, EGFP reporter, viral RNA and protein synthesis, and virus yield in three types of human cell lines, TE617, SF268 and HMC3, compared to wild type (WT), N139S SRIPs and i.c.s, which displayed more efficiency in replication kinetics. Additionally, E143K Natal RGN i.c. had greater activities of virus attachment and entry, yielded higher titers of intracellular and extracellular virions, and assembled the E proteins near to the plasma membrane in infected cells than the other i.c.s. The results indicate that the positively charged amino acid residue Lys143, a conserved residue in the pr region of prM of ZIKV African lineages, plays a crucial role in viral replication kinetics, including viral attachment, entry, assembly and egress. Thus, the negatively charged amino acid residue Glu143 within the pr region of prM leads to an alteration of the phenotypes, in particular, a lower replication efficiency of ZIKV Asian-lineage isolates with the attenuation of infectivity and cytopathicity.

171. Off-Target Effect of Activation of NF-κB by HIV Latency Reversal Agents on Transposable Elements Expression.

Viruses

2022 Jul 20

Curty G, Iniguez LP, Soares MA

172. Targeted Mutations in the Fusion Peptide Region of La Crosse Virus Attenuate Neuroinvasion and Confer Protection against Encephalitis.

Viruses

2022 Jul 2

Hollidge BS, Salzano MV, Ibrahim JM

173. Pseudorabies Virus Tegument Protein UL13 Suppresses RLR-Mediated Antiviral Innate Immunity through Regulating Receptor Transcription.

Viruses

2022 Jul 2

Zhao N, Wang F, Kong Z

174. Global Distribution and Natural Recombination of Hepatitis D Virus: Implication of Kyrgyzstan Emerging HDVs in the Clinical Outcomes.

Viruses

2022 Jul 2

Bahoussi AN, Wang PH, Guo YY

175. Wnt/β-Catenin Protects Lymphocytes from HIV-Mediated Apoptosis via Induction of Bcl-xL.

Viruses

2022 Jul 2

Albalawi YA, Narasipura SD, Al-Harthi L.

176. On the Parametrization of Epidemiologic Models-Lessons from Modelling COVID-19 Epidemic.

Viruses

2022 Jul 2

Kheifetz Y, Kirsten H, Scholz M.

177. Multi-Substituted Quinolines as HIV-1 Integrase Allosteric Inhibitors.

Viruses

2022 Jul 2

Dinh LP, Sun J, Glenn CD

178. Lung Transplant Recipients Immunogenicity after Heterologous ChAdOx1 nCoV-19-BNT162b2 mRNA Vaccination.

Viruses

2022 Jul 2

Catry E, Favresse J, Gillot C

179. Largemouth Bass Virus Infection Induced Non-Apoptotic Cell Death in MsF Cells.

Viruses

2022 Jul 19

Yang J, Xu W, Wang W

180. Hemagglutinin Subtype Specificity and Mechanisms of Highly Pathogenic Avian Influenza Virus Genesis.

Viruses

2022 Jul 19

de Bruin ACM, Funk M, Spronken MI

181. Predictive Models of within- and between-Species SARS-CoV-2 Transmissibility.

Viruses

2022 Jul 19

Soares R, Vieira CP, Vieira J.

182. Genetic Adaptation by Dengue Virus Serotype 2 to Enhance Infection of Aedes aegypti Mosquito Midguts.

Viruses

2022 Jul 19

Erb SM, Butrapet S, Roehrig JT

183. A Novel Framework for Modeling Person-to-Person Transmission of Respiratory Diseases.

Viruses

2022 Jul 19

Rodriguez J, Price O, Jennings R

184. Omicron BA.1 Mutations in SARS-CoV-2 Spike Lead to Reduced T-Cell Response in Vaccinated and Convalescent Individuals.

Viruses

2022 Jul 19

Emmelot ME, Vos M, Boer MC

185. Crocodilepox Virus Protein 157 Is an Independently Evolved Inhibitor of Protein Kinase R.

Viruses

2022 Jul 19

Rahman MJ, Tazi L, Haller SL

186. Viral and Cellular Factors Contributing to the Hematogenous Dissemination of Human Cytomegalovirus via Polymorphonuclear Leukocytes.

Viruses

2022 Jul 18

Braun B, Laib Sampaio K, Kuderna AK

187. Overview of Neutralization Assays and International Standard for Detecting SARS-CoV-2 Neutralizing Antibody.

Viruses

2022 Jul 18

Liu KT, Han YJ, Wu GH

188. Efficient Method for Generating Point Mutations in the Vaccinia Virus Genome Using CRISPR/Cas9.

Viruses

2022 Jul 18

Boutin L, Mosca E, Iseni F.

189. Novel Bat Lyssaviruses Identified by Nationwide Passive Surveillance in Taiwan, 2018-2021.

Viruses

2022 Jul 18

Hu SC, Hsu CL, Lee F

190. Generation of Reporter-Expressing New World Arenaviruses: A Systematic Comparison.

Viruses

2022 Jul 18

Fénéant L, Leske A, Günther K

191. A Testing Campaign Intervention Consisting of Peer-Facilitated Engagement, Point-of-Care HCV RNA Testing, and Linkage to Nursing Support to Enhance Hepatitis C Treatment Uptake among People Who Inject Drugs: The ETHOS Engage Study.

Viruses

2022 Jul 16

Conway A, Valerio H, Alavi M

192. Ways to Eliminate Viral Hepatitis as a Global Health Threat.

Viruses

2022 Jul 16

Flisiak R, Zarębska-Michaluk D, Flisiak-Jackiewicz M.

193. Viral Nucleases from Herpesviruses and Coronavirus in Recombination and Proofreading: Potential Targets for Antiviral Drug Discovery.

Viruses

2022 Jul 16

Wright LR, Wright DL, Weller SK.

194. Phosphomimetic S207D Lysyl-tRNA Synthetase Binds HIV-1 5'UTR in an Open Conformation and Increases RNA Dynamics.

Viruses

2022 Jul 16

Cantara WA, Pathirage C, Hatterschide J

195. Temporal and Spatial Patterns and a Space-Time Cluster Analysis of Foot-and-Mouth Disease Outbreaks in Ethiopia from 2010 to 2019.

Viruses

2022 Jul 16

Woldemariyam FT, Leta S, Assefa Z

Foot-and-mouth disease (FMD) is an endemic disease in Ethiopia, although space-time cluster and monthly variation studies have never been assessed at national level. The current study aimed to identify the spatial and temporal distribution of FMD outbreaks in Ethiopia from national outbreak reports over a period of ten years from 1 January 2010 to 31 December 2019. To this end, a total of 376,762 cases and 1302 outbreaks from 704 districts were obtained from the Minister of Agriculture for analyses. In general, the dry periods, i.e., October to March, of the year were recorded as the peak outbreak periods, with the highest prevalence in March 2012. The monthly average and the outbreak trends over ten years show a decrease of outbreaks from 2010 to 2019. Decomposing the FMD outbreak data time series showed that once an outbreak erupted, it continued for up to five years. Only 12% of the reported outbreaks were assigned to a specific serotype. Within these outbreaks, the serotypes O, A, SAT-2, and SAT-1 were identified in decreasing order of prevalence, respectively. When a window of 50% for the maximum temporal/space cluster size was set, a total of seven FMD clusters were identified in space and time. The primary cluster with a radius of 380.95 km was identified in the southern part of Ethiopia, with a likelihood ratio of 7.67 (observed/expected cases). The third cluster, with a radius of 144.14 km, was identified in the northeastern part of the country, and had a likelihood ratio of 5.66. Clusters 1 and 3 occurred from January 2017 to December 2019. The second cluster that occurred had a radius of 294.82 km, a likelihood ratio of 6.20, and was located in the central and western parts of Ethiopia. The sixth cluster, with a radius of 36.04 km and a likelihood ratio of 20.60, was set in southern Tigray, bordering Afar. Clusters 2 and 6 occurred in the same period, from January 2014 to December 2016. The fourth cluster in northern Tigray had a calculated radius of 95.50 km and a likelihood ratio of 1.17. The seventh cluster occurred in the north-central Amhara region, with a radius of 97 km and a likelihood ratio of 1.16. Clusters 4 and 7 occurred between January 2010 and December 2013. The spatiotemporal and cluster analysis of the FMD outbreaks identified in the context of the current study are crucial in implementing control, prevention, and a prophylactic vaccination schedule. This study pointed out October to March as well as the main time of the year during which FMD outbreaks occur. The area that extends from the south to north, following the central highlands, is the main FMD outbreak area in Ethiopia.

196. A Novel Competitive ELISA for Specifically Measuring and Differentiating Immune Responses to Classical Swine Fever C-Strain Vaccine in Pigs.

Viruses

2022 Jul 15

Wang L, Mi S, Madera R

197. Hepadnavirus DNA Is Detected in Canine Blood Samples in Hong Kong but Not in Liver Biopsies of Chronic Hepatitis or Hepatocellular Carcinoma.

Viruses

2022 Jul 15

Choi YR, Chen MC, Carrai M

198. Dynamics and Determinants of SARS-CoV-2 RT-PCR Testing on Symptomatic Individuals Attending Healthcare Centers during 2020 in Bahia, Brazil.

Viruses

2022 Jul 15

Pereira FM, Salomão de Araujo A, Catarina Martins Reis A

199. Clinical, Virological and Immunological Responses after Experimental Infection with African Horse Sickness Virus Serotype 9 in Immunologically Naïve and Vaccinated Horses.

Viruses

2022 Jul 15

Durán-Ferrer M, Villalba R, Fernández-Pacheco P

200. Think like a Virus: Toward Improving Nanovaccine Development against SARS-CoV-2.

Viruses

2022 Jul 15

Mohamed NA, Abou-Saleh H, Mohamed HA

201. Origins and Evolution of Seasonal Human Coronaviruses.

Viruses

2022 Jul 15

Otieno JR, Cherry JL, Spiro DJ

202. Systematic Review of Hepatitis C Virus Prevalence in the WHO Western Pacific Region.

Viruses

2022 Jul 15

Iversen J, Wand H, Chan PL

203. Expression of a Functional Mx1 Protein Is Essential for the Ability of RIG-I Agonist Prophylaxis to Provide Potent and Long-Lasting Protection in a Mouse Model of Influenza A Virus Infection.

Viruses

2022 Jul 15

Schwab LSU, Villalón-Letelier F, Tessema MB

204. Antiviral Effect of hBD-3 and LL-37 during Human Primary Keratinocyte Infection with West Nile Virus.

Viruses

2022 Jul 15

Chessa C, Bodet C, Jousselin C

205. Cap Is the Protease of the Porcine Circovirus 2.

Viruses

2022 Jul 15

Yang X, Yang W, Zhang W

206. Fish Innate Immune Response to Viral Infection-An Overview of Five Major Antiviral Genes.

Viruses

2022 Jul 15

Ortega-Villaizan MDM, Chico V, Perez L.

207. Development and Clinical Applications of a 5-Plex Real-Time RT-PCR for Swine Enteric Coronaviruses.

Viruses

2022 Jul 14

Zhu JH, Rawal G, Aljets E

208. Polyomavirus BK Genome Comparison Shows High Genetic Diversity in Kidney Transplant Recipients Three Months after Transplantation.

Viruses

2022 Jul 14

Mineeva-Sangwo O, Martí-Carreras J, Cleenders E

209. The Newly Identified Trichoderma harzianum Partitivirus (ThPV2) Does Not Diminish Spore Production and Biocontrol Activity of Its Host.

Viruses

2022 Jul 14

Wang R, Liu C, Jiang X

210. Retrospective Investigation in Horses with Encephalitis Reveals Unnoticed Circulation of West Nile Virus in Brazil.

Viruses

2022 Jul 14

Fritsch H, Pereira FM, Costa EA

211. Hepatitis B and C in Immigrants and Refugees in Central Brazil: Prevalence, Associated Factors, and Immunization.

Viruses

2022 Jul 14

Martins TLS, Silva GRDCE, Silva CA

212. Real-World Safety, Effectiveness, and Patient-Reported Outcomes in Patients with Chronic Hepatitis C Virus Infection Treated with Glecaprevir/Pibrentasvir: Updated Data from the German Hepatitis C-Registry (DHC-R).

Viruses

2022 Jul 14

Cornberg M, Stoehr A, Naumann U

213. The Cholesterol Transport Inhibitor U18666A Interferes with Pseudorabies Virus Infection.

Viruses

2022 Jul 14

Song B.

214. Galectin-9 and Interferon-Gamma Are Released by Natural Killer Cells upon Activation with Interferon-Alpha and Orchestrate the Suppression of Hepatitis C Virus Infection.

Viruses

2022 Jul 14

Carreca AP, Gaetani M, Busà R

215. Structure Prediction and Analysis of Hepatitis E Virus Non-Structural Proteins from the Replication and Transcription Machinery by AlphaFold2.

Viruses

2022 Jul 14

Goulet A, Cambillau C, Roussel A

216. An Optimized Checkerboard Method for Phage-Antibiotic Synergy Detection.

Viruses

2022 Jul 14

Nikolic I, Vukovic D, Gavric D

217. SARS-CoV-2 Seroprevalence among Healthcare Workers after the First and Second Pandemic Waves.

Viruses

2022 Jul 14

de Visscher N, Holemans X, Gillain A

Background: The Grand Hôpital de Charleroi is a large non-academic Belgian hospital that treated a large number of COVID-19 inpatients. In the context of this pandemic, all professions-combined healthcare workers (HCWs), and not only direct caregivers, are a frontline workforce in contact with suspected and confirmed COVID-19 cases and seem to be a high-risk group for exposure. The aim of our study was to estimate the prevalence of anti-SARS-CoV-2 antibodies in HCWs in our hospital after the first and second pandemic waves and to characterize the distribution of this seroprevalence in relation to various criteria. Methods: At the end of the two recruitment periods, a total of 4008 serological tests were performed in this single-center cross-sectional study. After completing a questionnaire including demographic and personal data, possible previous COVID-19 diagnostic test results and/or the presence of symptoms potentially related to COVID-19, the study participants underwent blood sampling and serological testing using DiaSorin's LIAISON® SARS-CoV-2 S1/S2 IgG test for the first phase and LIAISON® SARS-CoV-2 TrimericS IgG test for the second phase of this study. Results: In total, 302 study participants (10.72%) in the first round of the study and 404 (33.92%) in the second round were positive for SARS-CoV-2-IgG antibodies. The prevalence of seropositivity observed after the second wave was 3.16 times higher than after the first wave. We confirmed that direct, prolonged, and repeated contact with patients or their environment was a predominant seroconversion factor, but more unexpectedly, that this was the case for all HCWs and not only caregivers. Finally, the notion of high-risk contact seemed more readily identifiable in one's workplace than in one's private life. Conclusions: Our study confirmed that HCWs are at a significantly higher risk of contracting COVID-19 than the general population, and suggests that repeated contacts with at-risk patients, regardless of the HCWs' professions, represents the most important risk factor for seroconversion (Clinicaltrials.gov number, NCT04723290).

218. Virus Hijacks Host Proteins and Machinery for Assembly and Budding, with HIV-1 as an Example.

Viruses

2022 Jul 13

Lin CY, Urbina AN, Wang WH

219. An Updated Review on SARS-CoV-2 Infection in Animals.

Viruses

2022 Jul 13

Cui S, Liu Y, Zhao J

220. Nafamostat-Mediated Inhibition of SARS-CoV-2 Ribosomal Frameshifting Is Insufficient to Impair Viral Replication in Vero Cells. Comment on Munshi et al. Identifying Inhibitors of -1 Programmed Ribosomal Frameshifting in a Broad Spectrum of Coronaviruses. Viruses 2022, 14, 177.

Viruses

2022 Jul 13

Jäger N, Hoffmann M, Pöhlmann S

221. Evaluation of Two Broadly Used Commercial Methods for Detection of Respiratory Viruses with a Recently Added New Target for Detection of SARS-CoV-2.

Viruses

2022 Jul 13

Jevšnik Virant M, Uršič T, Kogoj R

222. Epidemiology and Ecology of Influenza A Viruses among Wildlife in the Arctic.

Viruses

2022 Jul 13

Gass JD Jr, Kellogg HK, Hill NJ

Arctic regions are ecologically significant for the environmental persistence and geographic dissemination of influenza A viruses (IAVs) by avian hosts and other wildlife species. Data describing the epidemiology and ecology of IAVs among wildlife in the arctic are less frequently published compared to southern temperate regions, where prevalence and subtype diversity are more routinely documented. Following PRISMA guidelines, this systematic review addresses this gap by describing the prevalence, spatiotemporal distribution, and ecological characteristics of IAVs detected among wildlife and the environment in this understudied region of the globe. The literature search was performed in PubMed and Google Scholar using a set of pre-defined search terms to identify publications reporting on IAVs in Arctic regions between 1978 and February 2022. A total of 2125 articles were initially screened, 267 were assessed for eligibility, and 71 articles met inclusion criteria. IAVs have been detected in multiple wildlife species in all Arctic regions, including seabirds, shorebirds, waterfowl, seals, sea lions, whales, and terrestrial mammals, and in the environment. Isolates from wild birds comprise the majority of documented viruses derived from wildlife; however, among all animals and environmental matrices, 26 unique low and highly pathogenic subtypes have been characterized in the scientific literature from Arctic regions. Pooled prevalence across studies indicates 4.23% for wild birds, 3.42% among tested environmental matrices, and seroprevalences of 9.29% and 1.69% among marine and terrestrial mammals, respectively. Surveillance data are geographically biased, with most data from the Alaskan Arctic and many fewer reports from the Russian, Canadian, North Atlantic, and Western European Arctic. We highlight multiple important aspects of wildlife host, pathogen, and environmental ecology of IAVs in Arctic regions, including the role of avian migration and breeding cycles for the global spread of IAVs, evidence of inter-species and inter-continental reassortment at high latitudes, and how climate change-driven ecosystem shifts, including changes in the seasonal availability and distribution of dietary resources, have the potential to alter host-pathogen-environment dynamics in Arctic regions. We conclude by identifying gaps in knowledge and propose priorities for future research.

223. SARS-CoV-2 Genomic Characteristics and Clinical Impact of SARS-CoV-2 Viral Diversity in Critically Ill COVID-19 Patients: A Prospective Multicenter Cohort Study.

Viruses

2022 Jul 13

Fourati S, Audureau E, Arrestier R

224. Stromal Interaction Molecule 1 Promotes the Replication of vvIBDV by Mobilizing Ca(2+) in the ER.

Viruses

2022 Jul 13

Yan N, Wang Y, Chen Z

225. Self-Repairing Herpesvirus Saimiri Deletion Variants.

Viruses

2022 Jul 13

Heyn I, Bremer L, Zingler P

226. Two Newly Isolated Enterobacter-Specific Bacteriophages: Biological Properties and Stability Studies.

Viruses

2022 Jul 12

Cieślik M, Harhala M, Orwat F

227. Occurrence, Distribution, and Transmission of Alfalfa Viruses in China.

Viruses

2022 Jul 12

Li J, Shang Q, Liu Y

228. Distinct Antibody Responses to Endemic Coronaviruses Pre- and Post-SARS-CoV-2 Infection in Kenyan Infants and Mothers.

Viruses

2022 Jul 12

Stoddard CI, Sung K, Ojee E

229. Women in the European Virus Bioinformatics Center.

Viruses

2022 Jul 12

Hufsky F, Abecasis A, Agudelo-Romero P

230. Multiple Receptors Involved in Invasion and Neuropathogenicity of Canine Distemper Virus: A Review.

Viruses

2022 Jul 12

Zhao J, Ren Y.

231. Nipah Virus Infection Generates Ordered Structures in Cellulo.

Viruses

2022 Jul 12

Vázquez CA, Widerspick L, Thuenauer R

232. Impact of COVID-19 Lockdown on the Nasopharyngeal Microbiota of Children and Adults Self-Confined at Home.

Viruses

2022 Jul 12

Rocafort M, Henares D, Brotons P

233. The Transmission Route and Selection Pressure in HCV Subtype 3a and 3b Chinese Infections: Evolutionary Kinetics and Selective Force Analysis.

Viruses

2022 Jul 11

Xu R, Rong X, Aranday-Cortes E

234. Monitoring Urban Zoonotic Virus Activity: Are City Rats a Promising Surveillance Tool for Emerging Viruses?

Viruses

2022 Jul 11

Camp JV, Desvars-Larrive A, Nowotny N

235. Avian Bornavirus Research-A Comprehensive Review.

Viruses

2022 Jul 11

Rubbenstroth D.

Viruses

2022 Jul 11

de Vasconcelos RAL, Ximenes RAA, Calado AA

237. Hepatitis B Vaccination: A Historical Overview with a Focus on the Italian Achievements.

Viruses

2022 Jul 11

Romano' L, Zanetti AR.

238. The Epidemiology and Variation in Pseudorabies Virus: A Continuing Challenge to Pigs and Humans.

Viruses

2022 Jul 1

Liu Q, Kuang Y, Li Y

Pseudorabies virus (PRV) can infect most mammals and is well known for causing substantial economic losses in the pig industry. In addition to pigs, PRV infection usually leads to severe itching, central nervous system dysfunction, and 100% mortality in its non-natural hosts. It should be noted that increasing human cases of PRV infection have been reported in China since 2017, and these patients have generally suffered from nervous system damage and even death. Here, we reviewed the current prevalence and variation in PRV worldwide as well as the PRV-caused infections in animals and humans, and briefly summarized the vaccines and diagnostic methods used for pseudorabies control. Most countries, including China, have control programs in place for pseudorabies in domestic pigs, and thus, the disease is on the decline; however, PRV is still globally epizootic and an important pathogen for pigs. In countries where pseudorabies in domestic pigs have already been eliminated, the risk of PRV transmission by infected wild animals should be estimated and prevented. As a member of the alphaherpesviruses, PRV showed protein-coding variation that was relatively higher than that of herpes simplex virus-1 (HSV-1) and varicella-zoster virus (VZV), and its evolution was mainly contributed to by the frequent recombination observed between different genotypes or within the clade. Recombination events have promoted the generation of new variants, such as the variant strains resulting in the outbreak of pseudorabies in pigs in China, 2011. There have been 25 cases of PRV infections in humans reported in China since 2017, and they were considered to be infected by PRV variant strains. Although PRV infections have been sporadically reported in humans, their causal association remains to be determined. This review provided the latest epidemiological information on PRV for the better understanding, prevention, and treatment of pseudorabies.

239. Effect of HTLV-1 Infection on the Clinical Course of Patients with Rheumatoid Arthritis.

Viruses

2022 Jul 1

Umekita K.

240. Characterization and Utilization of Disulfide-Bonded SARS-CoV-2 Receptor Binding Domain of Spike Protein Synthesized by Wheat Germ Cell-Free Production System.

Viruses

2022 Jul 1

Yamaoka Y, Jeremiah SS, Funabashi R

241. Safety of Biologic-DMARDs in Rheumatic Musculoskeletal Disorders: A Population-Based Study over the First Two Waves of COVID-19 Outbreak.

Viruses

2022 Jul 1

Sonaglia A, Comoretto R, Pasut E

242. Fulminant Adenoviral-Induced Hepatitis in Immunosuppressed Patients.

Viruses

2022 Jul 1

Kager J, Schneider J, Rasch S

Newmer生物

Newmer生物