The widespread availability and importance of large-scale protein-protein interaction (PPI) data demand a flurry of research efforts to understand the organisation of a cell and its functionality by analysing these data at the network level. In the bioinformatics and data mining fields, network clustering acquired a lot of attraction to examine a PPI network's topological and functional aspects. The clustering of PPI networks has been proven to be an excellent method for discovering functional modules, disclosing functions of unknown proteins, and other tasks in numerous research over the last decade. This research proposes a unique graph mining approach to detect protein complexes using dense neighbourhoods (highly connected regions) in an interaction graph. Our technique first finds size-3 cliques associated with each edge (protein interaction), and then these core cliques are expanded to form high-density subgraphs. Loosely connected proteins are stripped out from these subgraphs to produce a potential protein complex. Finally, the redundancy is removed based on the Jaccard coefficient. Computational results are presented on the yeast and human protein interaction dataset to highlight our proposed technique's efficiency. Predicted protein complexes of the proposed approach have a significantly higher score of similarity to those used as gold standards in the CYC-2008 and CORUM benchmark databases than other existing approaches.

Due to the crucial role of interactions between microRNAs (miRNAs) and long non-coding RNAs (lncRNAs) in biological processes, the study of their biological functions is necessary. So far, the various computational methods have been employed to make predictions of the miRNA-lncRNA interaction, which compensate for the inadequacy of biological experiments. However, the existing methods do not consider the differences between miRNA and lncRNA in feature extraction. In this paper, we propose a hybrid feature mining network, named PmliHFM, for predicting plant miRNA-lncRNA interactions. Firstly, miRNA and lncRNA with different sequence lengths are encoded by different encodings, which can reduce the loss of information caused by using the same coding approach. Then, a hybrid feature mining network is designed to adapt to different encoding methods and extract more useful feature information than a single network. Finally, an ensemble module is utilized to integrate the training results of the hybrid feature mining network, while a prediction module is employed to determine whether there are interactions. By testing on multiple test sets, PmliHFM outperforms several state-of-the-art approaches. The results show that the AUC of PmliHFM achieves 0.8[Formula: see text], 3.1[Formula: see text] and 0.4[Formula: see text] improvement respectively on three balanced datasets, and achieves 2.1[Formula: see text] and 1.8[Formula: see text] improvement respectively on two imbalanced datasets. These experiments demonstrate the feasibility of the proposed method.