Author information: (1)Cancer Genetics Service, Division of Medical Oncology, National Cancer Centre Singapore, Singapore, 169610, Singapore. (2)Oncology Academic Clinical Program, Duke-NUS Medical School, Singapore, 169857, Singapore. (3)Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, 308232, Singapore. (4)SingHealth Duke-NUS Institute of Precision Medicine, Singapore, 169609, Singapore. (5)Genome Research Informatics & Data Science Platform, Genome Institute of Singapore, Agency for Science, Technology and Research, Singapore, 138672, Singapore. (6)Saw Swee Hock School of Public Health, National University of Singapore, Singapore, 117549, Singapore. (7)Department of Obstetrics & Gynaecology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 119228, Singapore. (8)Singapore Institute for Clinical Sciences, Singapore, 117609, Singapore. (9)Cardiovascular and Metabolic Disorders Program, Duke-NUS Medical School, Singapore, 169857, Singapore. (10)SingHealth Duke-NUS Genomic Medicine Centre, Singapore, 168582, Singapore. (11)Personalized Medicine Service, Tan Tock Seng Hospital, Singapore, 308433, Singapore. (12)National Healthcare Group Polyclinics, Singapore, 138543, Singapore. (13)Genome Institute of Singapore, Agency for Science, Technology and Research, Singapore, 138672, Singapore. (14)Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, 168751, Singapore. (15)Laboratory of Systems Biology and Data Analytics, Genome Institute of Singapore, Agency for Science, Technology and Research, Singapore, 138672, Singapore. (16)Human Genomics, Genome Institute of Singapore, Agency for Science, Technology and Research, Singapore, 138672, Singapore. (17)Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 119228, Singapore. (18)Ophthalmology & Visual Sciences Academic Clinical Program (Eye ACP), Duke-NUS Medical School, Singapore, 169857, Singapore. (19)Bioinformatics Institute, Agency for Science, Technology and Research, Singapore, 138671, Singapore. (20)Human Development, Singapore Institute for Clinical Sciences, Singapore, 117609, Singapore. (21)Clinical Data Engagement, Bioinformatics Institute, Agency for Science, Technology and Research, Singapore, 138671, Singapore. (22)Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 117596, Singapore. (23)Department of Rheumatology, Allergy and Immunology, Tan Tock Seng Hospital, Singapore, 308433, Singapore. (24)Department of Cardiology, National Heart Centre Singapore, Singapore, 169609, Singapore. (25)Duke-NUS Medical School, Singapore, 169857, Singapore. (26)Precision Health Research Singapore (PRECISE), Singapore, 139234, Singapore. (27)Department of Epidemiology and Biostatistics, Imperial College London, London, W2 1PG, UK. (28)SingHealth Duke-NUS Institute of Precision Medicine, Singapore, 169609, Singapore. patrick.tan@precise.cris.sg. (29)Genome Institute of Singapore, Agency for Science, Technology and Research, Singapore, 138672, Singapore. patrick.tan@precise.cris.sg. (30)Precision Health Research Singapore (PRECISE), Singapore, 139234, Singapore. patrick.tan@precise.cris.sg. (31)Cancer & Stem Cell Biology Program, Duke-NUS Medical School, Singapore, 169857, Singapore. patrick.tan@precise.cris.sg. (32)Cancer Science Institute of Singapore, National University of Singapore, Singapore, 117599, Singapore. patrick.tan@precise.cris.sg. (33)SingHealth Duke-NUS Institute of Precision Medicine, Singapore, 169609, Singapore. Saumya.S.Jamuar@singhealth.com.sg. (34)SingHealth Duke-NUS Genomic Medicine Centre, Singapore, 168582, Singapore. Saumya.S.Jamuar@singhealth.com.sg. (35)Genetics Service, Department of Paediatrics, KK Women's and Children's Hospital, Singapore, 229899, Singapore. Saumya.S.Jamuar@singhealth.com.sg. (36)Paediatric Academic Clinical Program, Duke-NUS Medical School, Singapore, 169857, Singapore. Saumya.S.Jamuar@singhealth.com.sg. (37)Cancer Genetics Service, Division of Medical Oncology, National Cancer Centre Singapore, Singapore, 169610, Singapore. joanne.ngeow@ntu.edu.sg. (38)Oncology Academic Clinical Program, Duke-NUS Medical School, Singapore, 169857, Singapore. joanne.ngeow@ntu.edu.sg. (39)Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, 308232, Singapore. joanne.ngeow@ntu.edu.sg. (40)Institute of Molecular and Cellular Biology, Agency for Science, Technology and Research, Singapore, 138673, Singapore. joanne.ngeow@ntu.edu.sg. (41)SingHealth Duke-NUS Institute of Precision Medicine, Singapore, 169609, Singapore. wengkhong.lim@duke-nus.edu.sg. (42)SingHealth Duke-NUS Genomic Medicine Centre, Singapore, 168582, Singapore. wengkhong.lim@duke-nus.edu.sg. (43)Cancer & Stem Cell Biology Program, Duke-NUS Medical School, Singapore, 169857, Singapore. wengkhong.lim@duke-nus.edu.sg. (#)Contributed equally