Author information: (1)Department of Neuropathology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin Institute of Health, Berlin, Germany. josefine.radke@med.uni-greifswald.de. (2)German Cancer Consortium (DKTK), Partner Site Charité Berlin, Berlin, Germany. josefine.radke@med.uni-greifswald.de. (3)Institute of Pathology, Universitätsmedizin Greifswald, Greifswald, Germany. josefine.radke@med.uni-greifswald.de. (4)Digital Health Center, Berlin Institute of Health (BIH) at Charité - Universitätsmedizin Berlin, Berlin, Germany. naveed.ishaque@bih-charite.de. (5)Department of Neuropathology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin Institute of Health, Berlin, Germany. (6)German Cancer Consortium (DKTK), Partner Site Charité Berlin, Berlin, Germany. (7)Molecular Precision Oncology Program, NCT Heidelberg, Heidelberg, Germany. (8)Division of Applied Bioinformatics, German Cancer Research Center (DKFZ), Heidelberg, Germany. (9)Division of Translational Medical Oncology, National Center for Tumor Diseases (NCT), Heidelberg, Germany. (10)Computational Oncology, Molecular Diagnostics Program, NCT Heidelberg, Heidelberg, Germany. (11)Heidelberg Institute for Stem Cell Technology and Experimental Medicine (HI-STEM gGmbH), Heidelberg, Germany. (12)Department of Pediatric Oncology, Hematology and Immunology, University Hospital, Heidelberg, Germany. (13)German Cancer Consortium (DKTK), Heidelberg, Germany. (14)Division Neuroblastoma Genomics, German Cancer Research Center (DKFZ), Heidelberg, Germany. (15)Institute of Human Genetics, Ulm University & Ulm University Medical Center, Ulm, Germany. (16)Institut d'Investigacions Biomèdiques August Pi Sunyer (IDIBAPS), CIBER de Cáncer, Barcelona, Spain. (17)Division of Molecular Genome Analysis, German Cancer Research Center (DKFZ), Heidelberg, Germany. (18)Hopp Children's Cancer Center, NCT Heidelberg (KiTZ), Heidelberg, Germany. (19)Division of Pediatric Neurooncology, German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany. (20)Bioinformatics and Omics Data Analytics, German Cancer Research Center (DKFZ), Heidelberg, Germany. (21)Biomedical Informatics, Data Mining and Data Analytics, Augsburg University, Augsburg, Germany. (22)Institute of Pathology, Universitätsmedizin Greifswald, Greifswald, Germany. (23)Digital Health Center, Berlin Institute of Health (BIH) at Charité - Universitätsmedizin Berlin, Berlin, Germany. (24)Institute of Cell Biology (Cancer Research), Medical Faculty, University of Duisburg-Essen, Essen, Germany. (25)German Cancer Consortium (DKTK), Partner Site Essen, Essen, Germany. (26)Department of Hematology, Oncology and Cancer Immunology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin Institute of Health, Berlin, Germany. (27)Department of Neurosurgery, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin Institute of Health, Berlin, Germany. (28)Department for Neurosurgery, Vivantes Klinikum im Friedrichshain, Berlin, Germany. (29)Department for Neurosurgery, Vivantes Klinikum Neukölln, Berlin, Germany. (30)Department of Hematology and Oncology, Georg-Augusts-University of Göttingen, Göttingen, 37075, Germany. (31)Department of Pathology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin Institute of Health, Berlin, Germany. (32)Medical Department of Hematology and Oncology, Johannes Kepler University, Kepler Universitätsklinikum, Linz, Austria. (33)Department of Hematology, Oncology and Tumor Immunology and Molekulares Krebsforschungszentrum, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin Institute of Health, Berlin, Germany. (34)German Cancer Research Center (DKFZ), Heidelberg, Germany. (35)Genomics and Proteomics Core Facility, German Cancer Research Center (DKFZ), Heidelberg, Germany. (36)Department of Neurosurgery, University Hospital Heidelberg, Heidelberg, Germany. (37)Cluster of Excellence, NeuroCure, Charitéplatz 1, 10117, Berlin, Germany. (38)German Center for Neurodegenerative Diseases (DZNE) Berlin, 10117, Berlin, Germany. (#)Contributed equally