Author information: (1)Michigan Center for Translational Pathology, University of Michigan, Ann Arbor, MI, USA. (2)Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, USA. (3)Department of Pathology, University of Michigan, Ann Arbor, MI, USA. (4)Department of Pharmacology, University of Michigan, Ann Arbor, MI, USA. (5)Multiple Myeloma Research Foundation, Norwalk, CT, USA. (6)Howard Hughes Medical Institute, University of Michigan, Ann Arbor, MI, USA. (7)Department of Biostatistics, University of Michigan, Ann Arbor, MI, USA. (8)Department of Radiation Oncology, University of Michigan, Ann Arbor, MI, USA. (9)Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI, USA. (10)Department of Biostatistics, School of Public Health, University of Michigan, Ann Arbor, MI, USA. (11)Department of Internal Medicine, Division of Hematology and Oncology, University of Michigan, Ann Arbor, MI, USA. (12)Rogel Cancer Center, University of Michigan, Ann Arbor, MI, USA. (13)College of Human Medicine, Breslin Cancer Center, Michigan State University, East Lansing, MI, USA. (14)Division of Hematology, Department of Internal Medicine, Mayo Clinic, Phoenix, AZ, USA. (15)Michigan Center for Translational Pathology, University of Michigan, Ann Arbor, MI, USA. danrobi@umich.edu. (16)Department of Pathology, University of Michigan, Ann Arbor, MI, USA. danrobi@umich.edu. (17)Michigan Center for Translational Pathology, University of Michigan, Ann Arbor, MI, USA. arul@umich.edu. (18)Department of Pathology, University of Michigan, Ann Arbor, MI, USA. arul@umich.edu. (19)Howard Hughes Medical Institute, University of Michigan, Ann Arbor, MI, USA. arul@umich.edu. (20)Rogel Cancer Center, University of Michigan, Ann Arbor, MI, USA. arul@umich.edu. (21)Department of Urology, University of Michigan, Ann Arbor, MI, USA. arul@umich.edu. (#)Contributed equally