Author information: (1)Institute of Genetic Epidemiology, Faculty of Medicine and Medical Center - University of Freiburg, Freiburg, Germany. pascal.schlosser@uniklinik-freiburg.de. (2)Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA. pascal.schlosser@uniklinik-freiburg.de. (3)Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA. (4)Department of Medicine, University of Mississippi Medical Center, Jackson, MS, 39216, USA. (5)Research Unit Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, D-85764, Neuherberg, Bavaria, Germany. (6)Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, D-85764, Neuherberg, Bavaria, Germany. (7)TUM School of Medicine, Technical University of Munich, Munich, Germany. (8)Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands. (9)Framingham Heart Study, Framingham, Massachusetts, USA. (10)Population Sciences Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, US. (11)Department of Medicine and Genetics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, 19104, USA. (12)Department of Psychiatry and Psychotherapy, University Medicine Greifswald, Greifswald, Germany. (13)Program in Medical and Population Genetics, Broad Institute, Cambridge, MA, USA. (14)Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA, USA. (15)Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA. (16)Institute of Genetic Epidemiology, Faculty of Medicine and Medical Center - University of Freiburg, Freiburg, Germany. (17)MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK. (18)Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK. (19)Center for Research on Genomics and Global Health, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA. (20)Department of Public and Occupational Health, Amsterdam Public Health Research Institute, Amsterdam University Medical Centers, University of Amsterdam, 1105 AZ, Amsterdam, the Netherlands. (21)Department of Neurobiology, Care Sciences and Society (NVS), Family Medicine and Primary Care Unit, Karolinska Institutet, Huddinge, Sweden. (22)School of Health and Social Studies, Dalarna University, Falun, Sweden. (23)Population Health Sciences, German Centre for Neurodegenerative Diseases (DZNE), Bonn, Germany. (24)Department of Neurology, Faculty of Medicine, University of Bonn, Bonn, Germany. (25)Laboratory of Environmental Precision Health, Mailman School of Public Health, Columbia University, New York, NY, USA. (26)Center for Primary Care and Public Health (Unisanté), University of Lausanne, Lausanne, Switzerland. (27)German Cancer Research Center (DKFZ), Division of Clinical Epidemiology and Aging Research, Heidelberg, Germany. (28)Network Aging Research, Heidelberg University, Heidelberg, Germany. (29)Division of Preventive Oncology, German Cancer Research Center (DKFZ) and National Center for Tumor Diseases (NCT), Heidelberg, Germany. (30)German Cancer Consortium, German Cancer Research Center (DKFZ), Heidelberg, Germany. (31)Institute for Medical Biometry, Informatics and Epidemiology (IMBIE), Faculty of Medicine, University of Bonn, Bonn, Germany. (32)Population Health Laboratory, University of Fribourg, Fribourg, Switzerland. (33)Department of Epidemiology, Erasmus University Medical Center, Rotterdam, the Netherlands. (34)Department of Internal Medicine, Erasmus Medical Center, Rotterdam, the Netherlands. (35)Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore. (36)Department of Epidemiology and Biostatistics, Imperial College London, London, UK. (37)Department of Cardiology, Ealing Hospital, London North West Healthcare NHS Trust, Southall, UK. (38)Imperial College Healthcare NHS Trust, London, UK. (39)Texas Biomedical Research Institute, San Antonio, USA. (40)Lothian Birth Cohorts Group, Department of Psychology, The University of Edinburgh, 7 George Square, Edinburgh, EH8 9JZ, UK. (41)Department of Genetics, University Medical Center Groningen, University of Groningen, Hanzeplein 1, Groningen, the Netherlands. (42)Vth Department of Medicine, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany. (43)Department of Chronic Diseases Epidemiology, National Center for Epidemiology, Carlos III Health Institute, Madrid, Spain. (44)Department of Environmental Health Sciences, Columbia University Mailman School of Public Health, New York, NY, USA. (45)Department of Statistics and Operations Research, University of Valencia, Valencia, Spain. (46)Department of Nephrology and Hypertension, University of Erlangen-Nürnberg, Erlangen, Germany. (47)Department of Nephrology and Medical Intensive Care, Charité - Universitätsmedizin Berlin, Berlin, Germany. (48)Institute of Human Genetics, Friedrich-Alexander-UniversitätErlangen-Nürnberg, 91054, Erlangen, Germany. (49)Department of Anatomy and Cell Biology, University Medicine Greifswald, Greifswald, Germany. (50)DZHK (German Centre for Cardiovascular Research), Partner Site Greifswald, Greifswald, Germany. (51)Centre for Genomic and Experimental Medicine, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, EH4 2XU, UK. (52)Department of Medicine, University of Washington, Seattle, WA, 98101, USA. (53)Department of Epidemiology, University of Washington, Seattle, WA, 98101, USA. (54)Cardiovascular Health Research Unit, University of Washington, Seattle, WA, 98101, USA. (55)Brown Foundation Institute of Molecular Medicine, McGovern Medical School, Houston, TX, 77030, USA. (56)Human Genetics Center, Department of Epidemiology, Human Genetics and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, 77030, USA. (57)Oncode Institute, Utrecht, the Netherlands. (58)Department of Occupational and Environmental Health Sciences, School of Public Health, Peking University, Beijing, China. (59)Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany. (60)Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA. (61)Department of Clinical Genetics, Amsterdam Reproduction & Development Research Institute, Amsterdam University Medical Centres, University of Amsterdam, Amsterdam, the Netherlands. (62)Institute for Clinical Diabetology, German Diabetes Center, Leibniz Center for Diabetes Research at Heinrich Heine University Düsseldorf, Düsseldorf, Germany. (63)German Center for Diabetes Research, Munich-Neuherberg, Germany. (64)Department of Endocrinology and Diabetology, Medical Faculty and University Hospital Düsseldorf, Heinrich Heine University Düsseldorf, Düsseldorf, Germany. (65)Department of Human Genetics, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, 90095, USA. (66)Biostatistics, Fielding School of Public Health, UCLA, Los Angeles, CA, USA. (67)Department of Microbiology and Immunology, Faculty of Medicine and Health Technology, Tampere University, Tampere, 33014, Finland. (68)Division of Intramural Research, Population Sciences Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA. (69)Department of Epidemiology and Biostatistics, MRC-PHE Centre for Environment & Health, School of Public Health, Imperial College London, London, UK. (70)Center for Life Course Health Research, Faculty of Medicine, University of Oulu, 90014, Oulu, Finland. (71)Biocenter Oulu, University of Oulu, Oulu, Finland. (72)Unit of Primary Care, Oulu University Hospital, Oulu, Finland. (73)Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, 48104, USA. (74)Estonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia. (75)SYNLAB MVZ Humangenetik Mannheim, Mannheim, Germany. (76)Deutsches Herzzentrum München, Technische Universität München, Munich, Germany. (77)DZHK (German Centre for Cardiovascular Research), Partner site Munich Heart Alliance, Munich, Germany. (78)Institute of Epidemiology and Medical Biometry, University of Ulm, Ulm, Germany. (79)National Heart and Lung Institute, Imperial College London, London, UK. (80)Departments of Public Health Science and Medicine, Loyola University Chicago, Maywood, IL, USA. (81)Edward Hines VA Medical Center, Hines, IL, USA. (82)Institute of Genetic Epidemiology, Medical University of Innsbruck, Innsbruck, Austria. (83)Department of Clinical Chemistry, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland. (84)Finnish Cardiovascular Research Centre, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland. (85)Department of Clinical Chemistry, Fimlab Laboratories, Tampere, Finland. (86)Department of Medical Sciences, Uppsala University, Uppsala, Sweden. (87)Department of Medicine, Division of Cardiology, Duke Molecular Physiology Institute, Duke University School of Medicine, Durham, NC, USA. (88)Institute of Nutritional Sciences, Friedrich Schiller University Jena, Jena, Germany. (89)Competence Cluster for Nutrition and Cardiovascular Health (nutriCARD) Halle-Jena-Leipzig, Jena, Germany. (90)Synlab Academy, SYNLAB Holding Deutschland GmbH, Mannheim and Augsburg, Augsburg, Germany. (91)Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, Graz, Austria. (92)Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, Greifswald, Germany. (93)Ludwig-Maximilians Universität München, Munich, Germany. (94)Institute of Human Genetics, Klinikum rechts der Isar, Technische Universität München, Munich, Germany. (95)Department of Computational Health, Institute of Neurogenomics, Helmholtz Zentrum München, Munich, Germany. (96)Department of Health Services, University of Washington, Seattle, WA, 98101, USA. (97)Research centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland. (98)Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital, Turku, Finland. (99)Centre for Population Health Research, University of Turku and Turku University Hospital, Turku, Finland. (100)Joslin Diabetes Center, Boston, MA, USA. (101)Harvard Medical School, Boston, MA, USA. (102)Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA, USA. (103)Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, USA. (104)Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI, USA. (105)The George Institute for Global Health, University of New South Wales, Sydney, Australia. (106)Institute for Public Health Genetics, University of Washington, Seattle, WA, USA. (107)Department of Endocrinology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands. (108)Department of Cardiology, University Medical Center Groningen, University of Groningen, Hanzeplein 1, Groningen, the Netherlands. (109)Institute of Neurogenomics, Helmholtz Zentrum München, Munich, Germany. (110)Chair Neurogenetics, Klinikum rechts der Isar, Technische Universität München, Munich, Germany. (111)Munich Cluster for Systems Neurology (SyNergy), Munich, Germany. (112)DZHK (German Centre for Cardiovascular Research), Partner Site Greifswald, Greifswald, Germany. ateumer@uni-greifswald.de. (113)Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany. ateumer@uni-greifswald.de. (114)Department of Population Medicine and Lifestyle Diseases Prevention, Medical University of Bialystok, Bialystok, Poland. ateumer@uni-greifswald.de. (#)Contributed equally