生信网-文献期刊

Sci Rep

2023 May 9

Shimizu T, Sasaki Y, Ito K

2. Two legume fatty acid amide hydrolase isoforms with distinct preferences for microbial- and plant-derived acylamides.

Sci Rep

2023 May 9

Arias-Gaguancela O, Herrell E, Aziz M

3. Comprehensive analysis of mitophagy in HPV-related head and neck squamous cell carcinoma.

Sci Rep

2023 May 9

Yanan L, Hui L, Zhuo C

4. Aeolus winds impact on volcanic ash early warning systems for aviation.

Sci Rep

2023 May 9

Amiridis V, Kampouri A, Gkikas A

5. In-depth analysis on PTB7 based semi-transparent solar cell employing MoO(3)/Ag/WO(3) contact for advanced optical performance and light utilization.

Sci Rep

2023 May 9

Çokduygulular E, Çetinkaya Ç, Emik S

6. Nonlinear canonical correspondence analysis and its application.

Sci Rep

2023 May 9

Zhou L, Liu Z, Liu F

7. Pancancer analysis of oncogenic BARX2 identifying its prognostic value and immunological function in liver hepatocellular carcinoma.

Sci Rep

2023 May 9

Yu S(#), Yang Y(#), Yang H(#)

8. Data-driven automated control algorithm for floating-zone crystal growth derived by reinforcement learning.

Sci Rep

2023 May 9

Tosa Y, Omae R, Matsumoto R

9. Study on the emergency capacity of coal mine enterprises in Longdong Area based on D-FAHP method.

Sci Rep

2023 May 9

Yang F, Zhang J, Jin B

10. The role of final-state interaction in tensor polarization effects of the reaction [Formula: see text].

Sci Rep

2023 May 9

Gauzshtein V, Fix A, Vasilishin B

11. Streamlined quantitative analysis of histone modification abundance at nucleosome-scale resolution with siQ-ChIP version 2.0.

Sci Rep

2023 May 9

Dickson BM, Kupai A, Vaughan RM

12. 4,6-Diamino-2-thiopyrimidine-based Cobalt Metal Organic Framework (Co-DAT-MOF): green, efficient, novel and reusable nanocatalyst for synthesis of multicomponent reactions.

Sci Rep

2023 May 9

Ghorbani-Choghamarani A, Kakakhani Z, Taherinia Z.

13. Predictors of long-term neutralizing antibody titers following COVID-19 vaccination by three vaccine types: the BOOST study.

Sci Rep

2023 May 9

Prather AA, Dutcher EG, Robinson J

14. LncTUG1 contributes to the progression of hepatocellular carcinoma via the miR-144-3p/RRAGD axis and mTOR/S6K pathway.

Sci Rep

2023 May 9

Chen W(#), Bai Z(#), Bai W(#)

Hepatocellular carcinoma (HCC) is a symptomatic disease involed multi-stage program. Here, we elucidated the molecular mechanism of LncTUG1 in the regulation of HCC evolvement. And that may in all likelyhood supply a innovative latent target for HCC's diagnoses and prognosis. LncRNA TUG1, miR-144-3p, RRAGD and mTOR signaling pathway were screened as target genes in the database, and their expression levels at the cytological level were verified utilized qRT-PCR, Western Blot and immunohistochemistry. Then, we adopted CCK-8, Transwell and flow cytometry assays to estimate cell proliferation, invasion and apoptosis. By use of luciferase reporter assay, the relationships of LncRNA TUG1, miR-144-3p and RRAGD was confirmed. In addition, the LncRNA TUG1-miR-144-3p-RRAGD-mTOR signaling pathway in HCC cells was verified adopted rescue experiment and confirmed by xenotransplantation animal experiment. LncTUG1 in HCC tissues from three databases were identified and further verified through qRT-PCR in HCC cells (Huh7, Hep3B). Knockdown the LncTUG1 could increase apoptosis and inhibite invasion and proliferation in HCC cells. Using inhibitors and activators of the mTOR/S6K pathway, LncTUG1 was confirmed to regulate HCC progression by the mTOR/S6K pathway. Luciferase reporter assay demonstrated that TUG1 negatively regulates miR-144-3p. Furthermore, miR-144-3p negativly regulates RRAGD by way of interacting with the 3'UTR of the RRAGD mRNA in HCC utilized luciferase reporter assay. In vivo, we also discovered that neoplasm weight and tumor volume reduced significantly in subcutaneous xenograft nude mouse models derived from sh-LncTUG1-expressing Huh7 cells. And the expressions of p-mTOR, p-S6K and RRAGD were decreased obviously while the miR144-3p increased in subcutaneous xenograft nude mouse models. In a word, the research suggests that LncTUG1 targets miR-144-3p while miR-144-3p binds to RRAGD mRNA, which induces mTOR/S6K pathway activation and promotes the progression of HCC.

15. Development and validation of a continuous metabolic syndrome severity score in the Tehran Lipid and Glucose Study.

Sci Rep

2023 May 9

Honarvar M, Masoumi S, Mehran L

Metabolic syndrome (MetS), defined as the coexistence of interrelated cardiometabolic risk factors, is limited by ignoring the severity of the disease and individuals with a pre-metabolic state. We aimed to develop the first age- and sex-specific continuous MetS severity score in the adult population using confirmatory factor analysis (CFA) based on the MetS components in the Middle East. Using data from the population-based Tehran Lipid and Glucose Study (TLGS) I and II datasets, we conducted CFA of the single factor MetS on 8933 adults (20-60 years old) totally, and in age and sex subgroups. We allowed for different factor loadings across the subgroups to formulate age- and sex-specific continuous MetS severity score equations. Thereafter, we validated these equations in the dataset of TLGS III participants. Triglyceride had the highest factor loading across age and sex subgroups, indicating the most correlation with MetS. Except for women aged 40-60 years, waist circumference was the second most significant factor contributing to MetS. Systolic blood pressure was more closely related to MetS in women than in men. Systolic blood pressure and fasting plasma glucose had the weakest correlation with MetS among the 40-60 age group. Moreover, as women age, the contribution of fasting plasma glucose to MetS tended to decline, while it remained relatively constant in men. The resulting MetS severity score was correlated with age and homeostasis model assessment of insulin resistance. Furthermore, the continuous MetS severity score well predicted the traditional MetS according to receiver operating characteristic analysis in the validation dataset. The age- and sex-specific continuous MetS severity score for the West Asian adult population provides a tangible quantitative measure of MetS enabling clinicians to screen and monitor the individuals at risk and assess their metabolic trends.

16. Ketogenic diet enhances the effects of oxycodone in mice.

Sci Rep

2023 May 9

Trinko R, Diaz DM, Foscue E

17. Multimodal fusion models for pulmonary embolism mortality prediction.

Sci Rep

2023 May 9

Cahan N, Klang E, Marom EM

18. Plasma asymmetric dimethylarginine is associated with vulnerable plaque and long-term outcomes in stable coronary artery disease.

Sci Rep

2023 May 9

Huang SS, Huang WC, Tsai CT

19. Functional and phosphoproteomic analysis of β-adrenergic receptor signaling at excitatory synapses in the CA1 region of the ventral hippocampus.

Sci Rep

2023 May 9

Jami SA, Wilkinson BJ, Guglietta R

20. Evaluation of extraction methods for untargeted metabolomic studies for future applications in zebrafish larvae infection models.

Sci Rep

2023 May 9

Schippers P, Rasheed S, Park YM

21. Study on crystal growth of Ge/Si quantum dots at different Ge deposition by using magnetron sputtering technique.

Sci Rep

2023 May 9

Shu Q, Huang P, Yang F

22. Percutaneous transluminal angioplasty and stenting vs aggressive medical management on stroke or intracranial atherosclerotic stenosis: a systematic review and meta-analysis.

Sci Rep

2023 May 9

Lai Z(#), Peng M(#), He H

23. Increased gulf stream warm core ring formations contributes to an observed increase in salinity maximum intrusions on the Northeast Shelf.

Sci Rep

2023 May 9

Silver A, Gangopadhyay A, Gawarkiewicz G

24. MGMT is frequently inactivated in pancreatic NET-G2 and is associated with the therapeutic activity of STZ-based regimens.

Sci Rep

2023 May 9

Yagi K, Ono H, Kudo A

25. Landslide detection and inventory updating using the time-series InSAR approach along the Karakoram Highway, Northern Pakistan.

Sci Rep

2023 May 9

Hussain S, Pan B, Afzal Z

26. Prediction of clinically relevant postoperative pancreatic fistula using radiomic features and preoperative data.

Sci Rep

2023 May 9

Bhasker N(#), Kolbinger FR(#), Skorobohach N

27. Gamma irradiation induced surface modification of (PVC/HDPE)/ZnO nanocomposite for enhancing the oil removal and conductivity using COMSOL multiphysics.

Sci Rep

2023 May 9

Ghobashy MM, F Abd El-Gawad A, A Fayek S

28. Systemic changes in cell size throughout the body of Drosophila melanogaster associated with mutations in molecular cell cycle regulators.

Sci Rep

2023 May 9

Privalova V, Labecka AM, Szlachcic E

29. The legacy of one hundred years of climate change for organic carbon stocks in global agricultural topsoils.

Sci Rep

2023 May 9

Poeplau C, Dechow R.

30. Treatment of hypertension and obstructive sleep apnea counteracts cognitive decline in common neurocognitive disorders in diagnosis-related patterns.

Sci Rep

2023 May 9

Kujovic M, Lipka T, Zalman M

31. Testing entanglement of annihilation photons.

Sci Rep

2023 May 9

Ivashkin A, Abdurashitov D, Baranov A

32. A hybrid approach to full-scale reconstruction of renal arterial network.

Sci Rep

2023 May 9

Xu P, Holstein-Rathlou NH, Søgaard SB

33. Robust morphogenesis by chaotic dynamics.

Sci Rep

2023 May 9

Reinitz J, Vakulenko S(#), Sudakow I(#)

34. Subarctic-scale transport of (134)Cs to ocean surface off northeastern Japan in 2020.

Sci Rep

2023 May 9

Inoue M, Mashita K, Kameyama H

35. Spontaneous mutations in hlyD and tuf genes result in resistance of Dickeya solani IPO 2222 to phage ϕD5 but cause decreased bacterial fitness and virulence in planta.

Sci Rep

2023 May 9

Sokolova D, Smolarska A, Bartnik P

36. Nasolacrimal intubation in transcanalicular endoscopic dacryoplasty: a long-term follow-up study.

Sci Rep

2023 May 9

Zimmermann JA(#), Esser EL(#), Merté RL

37. Damage characteristics of weak rocks with different dip angles during creep.

Sci Rep

2023 May 9

Miao H, Zhao N, Meng L

38. Well-distributed 1T/2H MoS(2) nanocrystals in the N-doped nanoporous carbon framework by direct pyrolysis.

Sci Rep

2023 May 9

Baheri YT, Maleki M, Karimian H

39. Risk factors for patients with acute hospital-acquired symptomatic pulmonary thromboembolism.

Sci Rep

2023 May 9

Ye L, Xie H, Lai M

40. Brain-wide dendrites in a near-optimal performance of dynamic range and information transmission.

Sci Rep

2023 May 9

Lin C, Xu F, Zhang Y.

41. A deep-learning framework for spray pattern segmentation and estimation in agricultural spraying systems.

Sci Rep

2023 May 9

Acharya P, Burgers T, Nguyen KD.

42. Design, construction, and validation of an in-situ groundwater trace element analyzer with applications in carbon storage.

Sci Rep

2023 May 9

Hartzler DA, Bhatt CR, McIntyre DL.

43. A mechanical theory of competition between plant root growth and soil pressure reveals a potential mechanism of root penetration.

Sci Rep

2023 May 9

Tomobe H(#), Tsugawa S(#), Yoshida Y

44. Usefulness of the BACES score in nontuberculous mycobacterial pulmonary disease for various clinical outcomes.

Sci Rep

2023 May 9

Kim HJ, Song MJ, Kwon BS

45. Stochastic resonance analysis of a coupled high-speed maglev vehicle-bridge coupled system under bounded noise.

Sci Rep

2023 May 9

Li YX, Yu ZW, Xu L.

46. Assessments of sarcopenia and its associated factors in community-dwelling middle-aged and older Chinese adults in Kelantan, Malaysia.

Sci Rep

2023 May 9

Foo LH, Wen YS, Kadir AA.

47. Tuning the infrared resonance of thermal emission from metasurfaces working in near-infrared.

Sci Rep

2023 May 9

Rasoga O(#), Dragoman D(#), Dinescu A

48. Influence of in utero fetal death on perineal tears in vaginal deliveries.

Sci Rep

2023 May 9

Boudry T, Lallemant M, Ramanah R

The aim of this work was to evaluate and compare the incidence of perineal tears and Obstetrical anal sphincter injuries (OASIS) after vaginal delivery following a in utero fetal death (IUFD) compared with those with a live-birth. We conducted a single-center, retrospective cohort study using a database of all women who underwent a spontaneous vaginal delivery in the level III maternity ward. Exclusion criteria were breech presentation, cesarean section birth, instrumental delivery, multiple pregnancy, delivery before 24 + 6 weeks of gestation (WG) and termination of pregnancy for medical reasons. Women from the database were divided into two groups: an "in utero fetal death" (IUFD) group and a control group. Women were included in the IUFD group if they had a spontaneous vaginal delivery following a fetal demise after 24 + 6 WG in cephalic presentation between January 2006 and June 2020. Women in the "control" group were selected from the same database and were included if they underwent a spontaneous vaginal delivery of a live fetus in cephalic presentation, after 24 + 6 WG, during the same period. Each woman in the "IUFD" group was matched to two women (ratio 1:2) in the control group for parity, maternal age, body mass index, gestation and birth weight. The primary outcome was the presence of a sutured or unsutured perineal tear. During the study period, 31,208 patients delivered at a level III maternity hospital. Among them, 215 and 430 women were included in the IUFD group and the control group respectively. The two groups were comparable for all demographic and clinical characteristics except for an epidural analgesia (92% versus 70% in the control group, p < 0.01) and labor induction (86% versus 17% in the control group, p < 0.01). The incidence of any perineal tears was 13% (28/15) in the IUFD group versus 16% (70/430) in the control group. Relative risk of any perineal tears was non significative (RR = 0.8 IC95% [0.5-1.2]). The incidence of first-degree perineal tears was 10% in the IUFD group and 11% in the control group. The incidence of second-degree perineal tears was 18% in the IUFD group and 28% in the control group. Relative risk of first-degree perineal tears (RR = 0.88 95% CI [0.5-1.4]) and second-degree tears (RR = 0.51 95% CI [0.2-1.4]) were non significative. No obstetrical anal sphincter injury was found in either group. Vaginal delivery following a fetal demise did not appear to be either a risk factor or a protective factor for perineal tears. But there as a trend toward a lower incidence of second degree perineal tears in this context.

49. An assessment of microvascular hemodynamics in human macula.

Sci Rep

2023 May 9

Yu DY, Mehnert A, Balaratnasingam C

50. Boundary optimization of inclined coal seam open-pit mine based on the ISSA-LSSVR coal price prediction method.

Sci Rep

2023 May 9

Cao B, Wang S, Bai R

51. Bio-inspired artificial synapse for neuromorphic computing based on NiO nanoparticle thin film.

Sci Rep

2023 May 9

Hadiyal K, Ganesan R, Rastogi A

52. Graph matching and deep neural networks based whole heart and great vessel segmentation in congenital heart disease.

Sci Rep

2023 May 9

Yao Z, Xie W, Zhang J

53. Sibling competition, dispersal and fitness outcomes in humans.

Sci Rep

2023 May 9

Nitsch A, Faurie C, Lummaa V.

54. Distinct oncogenic phenotypes in hematopoietic specific deletions of Trp53.

Sci Rep

2023 May 9

Palanichamy JK, Tran TM, King JK

55. Genome-wide analysis of heavy metal ATPases (HMAs) in Poaceae species and their potential role against copper stress in Triticum aestivum.

Sci Rep

2023 May 9

Batool TS, Aslam R, Gul A

56. Preoperative imaging for hyperparathyroidism often takes upper parathyroid adenomas for lower adenomas.

Sci Rep

2023 May 9

Van den Bruel A, Bijnens J, Van Haecke H

57. Homomorphic inference of deep neural networks for zero-knowledge verification of nuclear warheads.

Sci Rep

2023 May 8

Turturica GV, Iancu V.

58. Hemodynamic and recirculation performance of dual lumen cannulas for venovenous extracorporeal membrane oxygenation.

Sci Rep

2023 May 8

Parker LP, Svensson Marcial A, Brismar TB

59. Evolutionary mechanisms underlying the diversification of nuclear factor of activated T cells across vertebrates.

Sci Rep

2023 May 8

Gamboa M, Kitamura N, Miura K

60. A two-dimensional grating surface made of quaternary Huygens elements excited by a real source.

Sci Rep

2023 May 8

Derafshi I, Komjani N, Ghasemi Mizuji E.

61. A novel dual feedwater circuit for a parabolic trough solar power plant.

Sci Rep

2023 May 8

Al-Maliki WAK, Alsaedi SS, Khafaji HQA

The validated dynamic model of a parabolic trough power plant (PTPP) is improved by the combination of a new feedwater circuit (feedwater/HTF circuit) and a reference feedwater circuit (feedwater/steam circuit) as well as the development of the steam turbine model. Such design represents the first effort of research to utilize a dual feedwater circuit inside the PTPP to increase the power output in the daylight from 50 to 68 MWel and raise night operating hours at a lower cost. The purpose of increasing the operating night hours at a power (48 MWel) as in the reference PTPP is to get rid of the fossil fuel backup system and rely only on the absorbed solar energy and the stored energy in the molten salt. During daylight hours, the feedwater circuit is operated using Feedwater/HTF. In the transient period, the feedwater/HTF circuit will gradually be closed due to a decrease in solar radiation. Furthermore, the rest of the nominal feedwater mass flow rate (49 kg/s) is gradually replenished from the feedwater/steam circuit. After sunset, the entirety of the feedwater is heated based on the steam extracted from the turbine. The purpose of this improvement is to raise the number of nightly operational hours by reducing the nominal load from 61.93 to 48 MWel as a result of low energy demand during the evening hours. Therefore, a comparison study between the reference model and this optimization (optimization 2) is conducted for clear days (26th-27th/June and 13th-14th/July 2010) in order to understand the influence of dual feedwater circuit. The comparison indicates that the operational hours of the power block (PB) will be obviously increased. Moreover, this improvement reduces based on the fossil fuel system at night. As the last step, an economic analysis was performed on the costs of the referenced and the optimized PTPP as a function of the levelized energy cost (LEC). The results illustrate that the specific energy cost of a PTPP with 7.5 h of storage capacity is lowered by about 14.5% by increasing the output of the PTPP from 50 to 68 MWel.

62. Driving factors on accumulation of cadmium, lead, copper, zinc in agricultural soil and products of the North China Plain.

Sci Rep

2023 May 8

Liu Z, Bai Y, Gao J

63. Pooled RNA-extraction-free testing of saliva for the detection of SARS-CoV-2.

Sci Rep

2023 May 8

Allicock OM(#), Yolda-Carr D(#), Todd JA

64. Fast vehicle detection based on colored point cloud with bird's eye view representation.

Sci Rep

2023 May 8

Wang L(#), Huang Y(#).

65. Meal-specific dietary patterns and biomarkers of insulin resistance in a sample of Iranian adults: a cross-sectional study.

Sci Rep

2023 May 8

Lesani A, Jayedi A, Karimi M

66. Active fixation as an efficient coding strategy for neuromorphic vision.

Sci Rep

2023 May 8

Testa S, Sabatini SP(#), Canessa A(#).

67. Development and characterization of agonistic antibodies targeting the Ig-like 1 domain of MuSK.

Sci Rep

2023 May 8

Lim JL(#), Augustinus R(#), Plomp JJ

68. Assessing the application of the revised Remane Model to fish species in a fluvially dominated cool-temperate southern African coastal system.

Sci Rep

2023 May 8

Nashima FP, Strydom NA, Lamberth SJ.

69. Structural and functional features of a broad-spectrum prophage-encoded enzybiotic from Enterococcus faecium.

Sci Rep

2023 May 8

Premetis GE, Stathi A, Papageorgiou AC

70. Optimizing 3DCT image registration for interfractional changes in carbon-ion prostate radiotherapy.

Sci Rep

2023 May 8

Hirai R, Mori S, Suyari H

To perform setup procedures including both positional and dosimetric information, we developed a CT-CT rigid image registration algorithm utilizing water equivalent pathlength (WEPL)-based image registration and compared the resulting dose distribution with those of two other algorithms, intensity-based image registration and target-based image registration, in prostate cancer radiotherapy using the carbon-ion pencil beam scanning technique. We used the data of the carbon ion therapy planning CT and the four-weekly treatment CTs of 19 prostate cancer cases. Three CT-CT registration algorithms were used to register the treatment CTs to the planning CT. Intensity-based image registration uses CT voxel intensity information. Target-based image registration uses target position on the treatment CTs to register it to that on the planning CT. WEPL-based image registration registers the treatment CTs to the planning CT using WEPL values. Initial dose distributions were calculated using the planning CT with the lateral beam angles. The treatment plan parameters were optimized to administer the prescribed dose to the PTV on the planning CT. Weekly dose distributions using the three different algorithms were calculated by applying the treatment plan parameters to the weekly CT data. Dosimetry, including the dose received by 95% of the clinical target volume (CTV-D95), rectal volumes receiving > 20 Gy (RBE) (V20), > 30 Gy (RBE) (V30), and > 40 Gy (RBE) (V40), were calculated. Statistical significance was assessed using the Wilcoxon signed-rank test. Interfractional CTV displacement over all patients was 6.0 ± 2.7 mm (19.3 mm maximum standard amount). WEPL differences between the planning CT and the treatment CT were 1.2 ± 0.6 mm-H2O (< 3.9 mm-H2O), 1.7 ± 0.9 mm-H2O (< 5.7 mm-H2O) and 1.5 ± 0.7 mm-H2O (< 3.6 mm-H2O maxima) with the intensity-based image registration, target-based image registration, and WEPL-based image registration, respectively. For CTV coverage, the D95 values on the planning CT were > 95% of the prescribed dose in all cases. The mean CTV-D95 values were 95.8 ± 11.5% and 98.8 ± 1.7% with the intensity-based image registration and target-based image registration, respectively. The WEPL-based image registration was CTV-D95 to 99.0 ± 0.4% and rectal Dmax to 51.9 ± 1.9 Gy (RBE) compared to 49.4 ± 9.1 Gy (RBE) with intensity-based image registration and 52.2 ± 1.8 Gy (RBE) with target-based image registration. The WEPL-based image registration algorithm improved the target coverage from the other algorithms and reduced rectal dose from the target-based image registration, even though the magnitude of the interfractional variation was increased.

71. Deep fake detection and classification using error-level analysis and deep learning.

Sci Rep

2023 May 8

Rafique R, Gantassi R, Amin R

72. Pharmaceutical payments to Japanese board-certified dermatologists: a 4-year retrospective analysis of personal payments from pharmaceutical companies between 2016 and 2019.

Sci Rep

2023 May 8

Murayama A, Kamamoto S, Saito H

There are prevalent financial relationships between dermatologists and pharmaceutical companies in Japan. However, little was known about the extent of whole picture of the personal payments made to dermatologists by pharmaceutical companies. This study aimed to examine the personal payments to the board-certified dermatologists by the Japanese Dermatological Association from the pharmaceutical companies between 2016 and 2019. Using the publicly disclosed payments data by the pharmaceutical companies between 2016 and 2019, we evaluated the magnitude, prevalence, and trends in the personal payments made to all board-certified dermatologists for the lecturing, writing, and consulting compensations. The payments were descriptively analyzed overall and by dermatologist demographics. Additionally, the payment trends were assessed by generalized estimating equation models. Of 6883 active board-certified dermatologists, 3121 (45.3%) received a total of $33,223,806 personal payments between 2016 and 2019. The median per-physician payments and number of payments (interquartile range) were $1737 ($613-$5287) and 4.0 (2.0-10.0) over the 4 years, respectively. Only top 1%, 5%, 10% of dermatologists received 41.7% (95% confidence interval [CI] 38.2-45.1%), 76.9% (95% CI 74.7-79.1%), and 87.6% (95% CI 86.2-88.9%) of overall payments. The number of dermatologists receiving payments and per-dermatologist payments increased by 4.3% (95% CI 3.1‒5.5%, p < 0.001) and 16.4% (95% CI 13.5‒19.4%, p < 0.001) each year. The board-certification in dermatology-oncology, in cosmetic dermatology, and male sex were significantly associated with higher personal payments with relative monetary values of 2.29 (95% CI 1.65-3.19, p < 0.001), 3.16 (95% CI 1.89-5.26, p < 0.001), and 5.38 (95% CI 4.12-7.04, p < 0.001). Less than half of Japanese board-certified dermatologists received lower personal payments from the pharmaceutical companies than those to other specialists. However, these personal payments were increasingly more prevalent and greater over the 4 years.

73. Nutrigonometry IV: Thales' theorem to measure the rules of dietary compromise in animals.

Sci Rep

2023 May 8

Morimoto J.

74. CD69 serves as a potential diagnostic and prognostic biomarker for hepatocellular carcinoma.

Sci Rep

2023 May 8

Tang K(#), Li X(#), Mo J(#)

75. Proof of concept nanotechnological approach to in vitro targeting of malignant melanoma for enhanced immune checkpoint inhibition.

Sci Rep

2023 May 8

Alharbi B, Qanash H, Binsaleh NK

76. Attribution and driving force of nitrogen losses from the Taihu Lake Basin by the InVEST and GeoDetector models.

Sci Rep

2023 May 8

He X, Tian J, Zhang Y

77. Accumulation of radiocarbon in ancient landscapes: A small but significant input of unknown origin.

Sci Rep

2023 May 8

Broz A, Aguilar J, Xu X

The persistence of organic carbon (C) in soil is most often considered at timescales ranging from tens to thousands of years, but the study of organic C in paleosols (i.e., ancient, buried soils) suggests that paleosols may have the capacity to preserve organic compounds for tens of millions of years. However, a quantitative assessment of C sources and sinks from these ancient terrestrial landscapes is complicated by additions of geologically modern (~ 10 Ka) C, primarily due to the infiltration of dissolved organic carbon. In this study, we quantified total organic C and radiocarbon activity in samples collected from 28- to 33-million-year-old paleosols that are naturally exposed as unvegetated badlands near eastern Oregon's "Painted Hills". We also used thermal and evolved gas analysis to examine the thermodynamic stability of different pools of C in bulk samples. The study site is part of a ~ 400-m-thick sequence of Eocene-Oligocene (45-28 Ma) paleosols, and thus we expected to find radiocarbon-free samples preserved in deep layers of the lithified, brick-like exposed outcrops. Total organic C, measured in three individual profiles spanning depth transects from the outcrop surface to a 1-m depth, ranged from 0.01 to 0.2 wt% with no clear C-concentration or age-depth profile. Ten radiocarbon dates from the same profiles reveal radiocarbon ages of ~ 11,000-30,000 years BP that unexpectedly indicate additions of potentially modern organic C. A two-endmember mixing model for radiocarbon activity suggests that modern C may compose ~ 0.5-2.4% of the total organic C pool. Thermal and evolved gas analysis showed the presence of two distinct pools of organic C, but there was no direct evidence that C compounds were associated with clay minerals. These results challenge the assumption that ancient badland landscapes are inert and "frozen in time" and instead suggest they readily interact with the modern C cycle.

78. Eye lens-derived Δ(14)C signatures validate extreme longevity in the deepwater scorpaenid blackbelly rosefish (Helicolenus dactylopterus).

Sci Rep

2023 May 8

Chamberlin DW, Siders ZA, Barnett BK

79. Transmission dynamics of a novel HIV/AIDS model through a higher-order Galerkin time discretization scheme.

Sci Rep

2023 May 8

Attaullah, Zeb K, Khan I

80. Plasma-based one-step synthesis of tungsten oxide nanoparticles in short time.

Sci Rep

2023 May 8

Baharlounezhad F, Mohammadi MA, Zakerhamidi MS.

81. Spontaneously occurring tumors in different wild-derived strains of hydra.

Sci Rep

2023 May 8

Boutry J, Buysse M, Tissot S

82. Age-dependent differences and similarities in the plasma proteomic signature of postoperative delirium.

Sci Rep

2023 May 8

Oren RL, Kim EJ, Leonard AK

83. Toward explainable heat load patterns prediction for district heating.

Sci Rep

2023 May 8

Dang LM, Shin J, Li Y

84. Achromatic and chromatic contrast discrimination in patients with type 2 diabetes.

Sci Rep

2023 May 8

Tsai LT, Chen CC, Hou CH

85. Training a quantum measurement device to discriminate unknown non-orthogonal quantum states.

Sci Rep

2023 May 8

Concha D, Pereira L, Zambrano L

86. Fluorescence resonance energy transfer (FRET) spatiotemporal mapping of atypical P38 reveals an endosomal and cytosolic spatial bias.

Sci Rep

2023 May 8

Burton JC, Okalova J, Grimsey NJ.

87. Comparative plastome genomics, taxonomic delimitation and evolutionary divergences of Tetraena hamiensis var. qatarensis and Tetraena simplex (Zygophyllaceae).

Sci Rep

2023 May 8

Ahmad W(#), Asaf S(#), Al-Rawahi A

88. Unique inverse association between allergic rhinitis and periodontitis: a nationwide population-based study.

Sci Rep

2023 May 8

Kim DY, Lee JK, Pang EK

89. Nd:YAG 1064-nm laser for residual infantile hemangioma after propranolol treatment.

Sci Rep

2023 May 8

Khamaysi Z, Pam N, Zaaroura H

90. Broadband and high-efficiency polarization conversion with a nano-kirigami based metasurface.

Sci Rep

2023 May 8

Liu X, Zhang X, Dong W

91. Caldera collapse thresholds correlate with magma chamber dimensions.

Sci Rep

2023 May 8

Geshi N, Miyagi I, Saito G

92. Optimized spirooxindole-pyrazole hybrids targeting the p53-MDM2 interplay induce apoptosis and synergize with doxorubicin in A549 cells.

Sci Rep

2023 May 8

Islam MS, Al-Majid AM, Sholkamy EN

93. Unexpected silicon localization in calcium carbonate exoskeleton of cultured and fossil coccolithophores.

Sci Rep

2023 May 7

Bordiga M, Lupi C, Langer G

94. Energy transfer across magnetopause under dawn-dusk IMFs.

Sci Rep

2023 May 7

Zhang HX, Lu JY, Wang M.

A parametric study on the energy transfer of the solar wind across the magnetopause entering the magnetosphere is conducted using a global magnetohydrodynamic numerical simulation. The characteristics of the mechanical and electromagnetic energy distribution under the dawn-dusk interplanetary magnetic fields (IMFs) are investigated by analyzing magnetic reconnection and viscous effect, and compared with the radial and north-south IMFs. It is shown that (1) the interactions at the magnetopause and the transfer of energy across this boundary move in relation to the IMF orientation. (2) For the duskward IMF, the mechanical energy flow clearly enters the equatorial and low-latitude regions on the dayside, and the electromagnetic energy flow has a small inflow on the equatorial and low latitudes of the dayside. A significant energy inflow appears on the dawn side in the northern hemisphere and the dusk side in the southern hemisphere near the polar cusp. (3) The energy distribution characteristics across the magnetopause under dawn-dusk IMFs are mirror symmetric about the [Formula: see text] plane. (4) For a magnetic field of 5 nT, the electromagnetic energy input under the dawn-dusk IMFs is twice as large as the mechanical energy and the electromagnetic energy under the radial IMF, which is five times as large as the electromagnetic energy during the pure northward IMF, but only half as large as the electromagnetic energy under the pure southward IMF. The mechanical energy input under dawn-dusk IMFs has the same magnitude as that under radial and north-south IMFs. The magnitude of the energy transfer rate for the dawn IMF and dusk IMF (about 3.5%) is between 1.71% for the northward IMF and 4.95% for the southward IMF, but higher than 2.22% for the radial IMF. The Akasofu-type energy-coupling formula, [Formula: see text], underestimates the energy input from the solar wind under [Formula: see text] dominated IMF.

95. Study on seismic vulnerability analysis of the interaction system between saturated soft soil and subway station structures.

Sci Rep

2023 May 7

Cheng X, Li Q, Hai R

The seismic vulnerability of interaction system of saturated soft soil and subway station structures was explored in this paper. The coupled nonlinear numerical models of interaction system were established using the u-p formulation of Biot's theory to describe the saturated two-phase media. A refined finite element model of interaction system was developed to study its nonlinear seismic responses and seismic hazard mechanism. In this study, the multi-yield elastoplastic constitutive model was adopted for the soil, while a fiber section elastoplastic constitutive model was used for the structure. The seismic response of the structure was calculated by inputting the artificial seismic wave obtained from the power spectrum-triangular series method. The maximum inter-story drift angle was taken as a structural performance parameter for the subway station structure. The structural demand cloud was obtained under random ground motion sequences. Based on the probabilistic seismic demand model analysis method, the seismic vulnerability curve of the subway station structure was plotted, and the seismic vulnerability curve was analyzed as per the vulnerability of performance parameters. With the increase of soil strength, the vulnerability index of subway station structure under different peak acceleration ground motion decreased correspondingly. Based on the above vulnerability theory and analysis methods, it can be found from the above vulnerability theory and analysis methods that the subway station structure with established buried depth in saturated soft soil site exhibits a certain degree of safety and reliability, and can meet the seismic fortification goal of "no damage in small earthquakes, repairable in medium earthquakes and no collapse in large earthquakes". The results of vulnerability analysis are in line with the actual seismic survey, and the vulnerability analysis method proposed in this paper can be applied to the vulnerability analysis of underground structures on saturated soft soil foundation.

96. Correlation of index finger length to vertical dimensions of occlusion for edentulous patients and their satisfaction: a randomized controlled trial.

Sci Rep

2023 May 7

Khan SA, Raza Kazmi SM, Ahmed S

97. Resting-state oscillations reveal disturbed excitation-inhibition ratio in Alzheimer's disease patients.

Sci Rep

2023 May 7

van Nifterick AM, Mulder D, Duineveld DJ

98. Running Energy Reserve Index (RERI) as a new model for assessment and prediction of world, elite, sub-elite, and collegiate running performances.

Sci Rep

2023 May 7

Balasekaran G, Loh MK, Boey P

99. Designing highly potent compounds using a chemical language model.

Sci Rep

2023 May 7

Chen H, Bajorath J.

100. Biosynthesis, characterization and anthelmintic activity of silver nanoparticles of Clerodendrum infortunatum isolate.

Sci Rep

2023 May 7

Majumdar R, Kar PK.

101. Peripheral targets attenuate miniature eye movements during fixation.

Sci Rep

2023 May 7

Watamaniuk SNJ, Badler JB, Heinen SJ.

102. Plasma chemokines CXCL10 and CXCL9 as potential diagnostic markers of drug-sensitive and drug-resistant tuberculosis.

Sci Rep

2023 May 6

Sampath P(#), Rajamanickam A(#), Thiruvengadam K

103. Possible origins and implications of atypical morphologies and domestication-like traits in wild golden jackals (Canis aureus).

Sci Rep

2023 May 6

Barash A(#), Preiss-Bloom S(#), Machluf Y(#)

104. Thermoelasticity of ice explains widespread damage in dripstone caves during glacial periods.

Sci Rep

2023 May 6

Spötl C, Jarosch AH, Saxer A

105. Numerical analysis of predatory potentiality of Toxorhynchites splendens against larval Aedes albopictus in laboratory and semi-field conditions.

Sci Rep

2023 May 6

Malla RK, Mandal KK, Burman S

106. A novel microbe-drug association prediction model based on stacked autoencoder with multi-head attention mechanism.

Sci Rep

2023 May 6

Fan L, Wang L, Zhu X.

107. High Curie temperature ferromagnetic structures of (Sb(2)Te(3))(1-x)(MnSb(2)Te(4))(x) with x = 0.7-0.8.

Sci Rep

2023 May 6

Levy I, Forrester C, Ding X

108. Silane modification of TiO(2) nanoparticles and usage in acrylic film for effective photocatalytic degradation of methylene blue under visible light.

Sci Rep

2023 May 6

Ataabadi MR, Jamshidi M.

109. Blood spinal cord barrier disruption recovers in patients with degenerative cervical myelopathy after surgical decompression: a prospective cohort study.

Sci Rep

2023 May 6

Schmidt TP, Jütten K, Bertram U

The pathophysiology of degenerative cervical myelopathy (DCM) is characterized by chronic compression-induced damage to the spinal cord leading to secondary harm such as disruption of the blood spinal cord barrier (BSCB). It is therefore the purpose of this study to analyze BSCB disruption in pre- and postoperative DCM patients and to correlate those with the clinical status and postoperative outcome. This prospectively controlled cohort included 50 DCM patients (21 female; 29 male; mean age: 62.9 ± 11.2 years). As neurological healthy controls, 52 (17 female; 35 male; mean age 61.8 ± 17.3 years) patients with thoracic abdominal aortic aneurysm (TAAA) and indication for open surgery were included. All patients underwent a neurological examination and DCM-associated scores (Neck Disability Index, modified Japanese Orthopaedic Association Score) were assessed. To evaluate the BSCB status, blood and cerebrospinal fluid (CSF) samples (lumbar puncture or CSF drainage) were taken preoperatively and in 15 DCM patients postoperatively (4 female; 11 male; mean age: 64.7 ± 11.1 years). Regarding BSCB disruption, CSF and blood serum were examined for albumin, immunoglobulin (Ig) G, IgA and IgM. Quotients for CSF/serum were standardized and calculated according to Reiber diagnostic criteria. Significantly increased preoperative CSF/serum quotients were found in DCM patients as compared to control patients: AlbuminQ (p < .001), IgAQ (p < .001) and IgGQ (p < .001). IgMQ showed no significant difference (T = - 1.15, p = .255). After surgical decompression, neurological symptoms improved in DCM patients, as shown by a significantly higher postoperative mJOA compared to the preoperative score (p = .001). This neurological improvement was accompanied by a significant change in postoperative CSF/serum quotients for Albumin (p = .005) and IgG (p = .004) with a trend of a weak correlation between CSF markers and neurological recovery. This study further substantiates the previous findings, that a BSCB disruption in DCM patients is evident. Interestingly, surgical decompression appears to be accompanied by neurological improvement and a reduction of CSF/serum quotients, implying a BSCB recovery. We found a weak association between BSCB recovery and neurological improvement. A BSCB disruption might be a key pathomechanism in DCM patients, which could be relevant to treatment and clinical recovery.

110. Fickian yet non-Gaussian diffusion of a quasi-2D colloidal system in an optical speckle field: experiment and simulations.

Sci Rep

2023 May 6

Ciarlo A, Pastore R, Greco F

111. The difference in the cellular uptake of tocopherol and tocotrienol is influenced by their affinities to albumin.

Sci Rep

2023 May 6

Nakatomi T, Itaya-Takahashi M, Horikoshi Y

112. Prenatal DEHP exposure predicts neurological disorders via transgenerational epigenetics.

Sci Rep

2023 May 6

Tran MTMT(#), Kuo FC(#), Low JT

113. Optimized metrics for orthogonal combinatorial CRISPR screens.

Sci Rep

2023 May 6

Cetin R, Wegner M, Luwisch L

114. Experimental investigation on a solar parabolic collector using water-based multi-walled carbon-nanotube with low volume concentrations.

Sci Rep

2023 May 6

Talugeri V, Pattana NB, Nasi VB

115. Transfer and transformation characteristics of Zn and Cd in soil-rotation plant (Brassica napus L and Oryza sativa L) system and its influencing factors.

Sci Rep

2023 May 6

Yan Q, Fang H, Wang D

116. Detection of long terminal repeat loci derived from endogenous retrovirus in junglefowl using whole-genome sequencing.

Sci Rep

2023 May 6

Ishihara S.

117. A water cooled, high power, dielectric barrier discharge reactor for CO(2) plasma dissociation and valorization studies.

Sci Rep

2023 May 6

Lisi N, Pasqual Laverdura U, Chierchia R

118. Explainable semi-supervised deep learning shows that dementia is associated with small, avocado-shaped clocks with irregularly placed hands.

Sci Rep

2023 May 6

Bandyopadhyay S(#), Wittmayer J(#), Libon DJ

119. Association of gamma-glutamyl transferase variability with risk of venous thrombosis.

Sci Rep

2023 May 6

Chang Y, Lee H, Song TJ.

Gamma-glutamyl transferase (GGT) is a biomarker of inflammation, and is known to be associated with stroke and atrial fibrillation. Venous thromboembolism (VT), a not uncommon thrombotic disorder, shares similar mechanisms with other thrombotic disorders including these stroke and atrial fibrillation. Given these associations, we intended to investigate the potential association between variability in GGT and VT. The study included data from the National Health Insurance Service-Health Screening Cohort, comprising 1,085,105 participants with health examinations 3 or more times from 2003 to 2008. Variability indexes were the coefficient of variation, standard deviation, and variability independent of the mean. The occurrence of venous thromboembolism (VT) was defined with more than one claim of the following ICD-10 codes: deep VT (I80.2-80.3), pulmonary thromboembolism (I26), intraabdominal venous thrombosis (I81, I82.2, I82.3), or other VT (I82.8, I82.9). To determine the relationship of quartiles of GGT with incident VT risk, Kaplan-Meier survival curve and logrank test were used. Cox's proportional hazard regression was used to investigate the risk of VT occurrence by GGT quartile (Q1-Q4). A total of 1,085,105 subjects were incorporated in the analysis, and the average follow-up was 12.4 years (interquartile range 12.2-12.6). VT occurred in 11,769 (1.08%) patients. The GGT level was measured 5,707,768 times in this stud. Multivariable analysis showed that GGT variability were positively associated with the occurrence of VT. Compared to the Q1, the Q4 showed an adjusted HR of 1.15 (95% CI 1.09-1.21, p < 0.001) when using coefficient of variation, 1.24 (95% CI 1.17-1.31, p < 0.001) when using standard deviation, and 1.10 (95% CI 1.05-1.16, p < 0.001) when using variability independent of the mean. Increased variability of GGT may be related to an increased risk of VT. Maintaining a stable GGT level would be beneficial in reducing the risk of VT.

120. Spatio-temporal analysis and simulation of urban ecological resilience in Guangzhou City based on the FLUS model.

Sci Rep

2023 May 6

Liao Z, Zhang L.

Prediction of urban ecological risk, which is increasing with the rapid development of China's economy, has become more complex and difficult, resulting in great damage to the safety of people's lives and property and the quality of the ecological environment. Elucidation of the change mechanism of the urban ecological resilience level from the perspective of the resilience characteristics and exploration of the spatiotemporal differences of the urban ability are necessary to prevent and resolve ecological risks. To this end, here, a model for the evaluation of urban ecological resilience was constructed by considering three aspects: resistance, adaptability, and resilience. The spatiotemporal change pattern of urban ecological resilience in Guangzhou from 2000 to 2020 was evaluated. Furthermore, a spatial autocorrelation model was used to explore the management model of Guangzhou's ecological resilience in 2020. Finally, based on the FLUS model, the spatial pattern of urban land use under the 2035 benchmark and innovation- and entrepreneurship-oriented scenarios was simulated and the spatial distribution of the ecological resilience level under different urban development scenarios was evaluated. We found that from 2000 to 2020, areas with a low ecological resilience expanded to the northeast and southeast, whereas areas with a high ecological resilience significantly decreased; from 2000 to 2010, original high-level regions in the northeast and east of Guangzhou were transformed into medium level regions. Further, in 2020, the southwestern region of the city will show a low level of resilience and high density of pollutant discharge enterprises, indicating that the ability to prevent and resolve environmental and ecological risks in this region is relatively low. Additionally, the overall ecological resilience of Guangzhou under the innovation- and entrepreneurship-oriented "City of Innovation" urban development scenario is higher than that under the benchmark scenario in 2035. The results of this study provide a theoretical basis for the development of resilient urban ecological environment.

121. Pachychoroid neovasculopathy has clinical properties that differ from conventional neovascular age-related macular degeneration.

Sci Rep

2023 May 6

Kuranami A, Maruko R, Maruko I

To determine the clinical properties of pachychoroid neovasculopathy (PNV) that differ from conventional neovascular age-related macular degeneration (nAMD) and suggest that they are different clinical entities. To accomplish this, we reviewed the medical records of 100 consecutive patients diagnosed with nAMD. All of the patients were Japanese, and their mean age was 75.5 years. There were 72 men and 28 women. For the bilateral cases, only the right eye was analyzed. An eye was diagnosed with PNV when a macular neovascularization (MNV) was detected just above the dilated choroidal vessels. The Indocyanine green angiographic (ICGA) and en face optical coherence tomographic (OCT) images were used to assess the vertical symmetry of the medium and large choroidal vessels. The subfoveal choroidal thickness (SCT) was also measured manually in the OCT images. After reclassification, there were 29 (29%) patients with typical nAMD (25 with type 1 MNV, 4 with type 2 MNV), 43 (43%) with PNV, 21 (21%) with polypoidal choroidal vasculopathy, and 7 (7%) with retinal angiomatous proliferation. Of the 43 PNV, 17 (39.5%) had polypoidal lesions and 26 (60.5%) had no polypoidal lesions. The percentage of eyes with vertical asymmetry of the medium and large choroidal vessels was significantly greater in the 35 PNV (81.4%) than in the 16 non-PNV (28.1%; P < 0.01) cases. The mean SCT was significantly thicker in the PNV eyes than in the non-PNV eyes (298 ± 96 μm vs. 228 ± 82 μm; P < 0.01). The response of PNV to anti-vascular endothelial growth factor treatments was better than that of non-PNV eyes [higher dry macula rate after the loading period (90.9% vs. 59.1%), fewer total number of injections (11.0 ± 2.9 vs. 13.4 ± 3.2), and longer treatment intervals for the anti-VEGF therapy (8.4 ± 3.1 vs. 13.4 ± 3.2 weeks) at 2 years (all P < 0.01)]. These differences in the morphology and response to anti-VEGF treatments suggest that PNV is a separate clinical entity to conventional nAMD.

122. Improved anticancer efficacy of methyl pyropheophorbide-a-incorporated solid lipid nanoparticles in photodynamic therapy.

Sci Rep

2023 May 6

Yeo S(#), Lee TH(#), Kim MJ

123. The cytoplasmic N-terminal tail of Zika virus NS4A protein forms oligomers in the absence of detergent or lipids.

Sci Rep

2023 May 5

Surya W, Liu Y, Torres J.

124. Activity of pemetrexed in pre-clinical chordoma models and humans.

Sci Rep

2023 May 5

Kesari S(#), Wang F(#), Juarez T

125. Ability of detecting and willingness to share fake news.

Sci Rep

2023 May 5

Arin KP, Mazrekaj D, Thum M.

126. Structural, optical, and cytotoxicity studies of laser irradiated ZnO doped borate bioactive glasses.

Sci Rep

2023 May 5

Ghazy AR, Elmowafy BM, Abdelghany AM

127. Construction of deep learning-based disease detection model in plants.

Sci Rep

2023 May 5

Jung M(#), Song JS(#), Shin AY(#)

128. Perceptions of intelligence & sentience shape children's interactions with robot reading companions.

Sci Rep

2023 May 5

Caruana N, Moffat R, Miguel-Blanco A

129. Linking plant and vertebrate species to Nature's Contributions to People in the Swiss Alps.

Sci Rep

2023 May 5

Rey PL, Vittoz P, Petitpierre B

130. Modulation of pulmonary desmosomes by inhaler therapy in preterm-born children with bronchopulmonary dysplasia.

Sci Rep

2023 May 5

Course CW, Lewis PA, Kotecha SJ

131. Physical and chemical properties of Coarse Woody Debris submitted to the natural process of decomposition in a Secondary Atlantic Forest Fragment in Brazil.

Sci Rep

2023 May 5

Villanova PH, Torres CMME, Jacovine LAG

132. Sustainability transition for Indian agriculture.

Sci Rep

2023 May 5

Paul B, Murari KK, Patnaik U

133. A new regional cotton growth model based on reference crop evapotranspiration for predicting growth processes.

Sci Rep

2023 May 5

Lin S, Deng M, Wei K

134. The potential role of pumpkin seeds oil on methotrexate-induced lung toxicity.

Sci Rep

2023 May 5

Abosrea AM, Aboul Ezz HS, Mahmoud SM

135. In vitro and in vivo susceptibility to sulfadiazine and pyrimethamine of Toxoplasma gondii strains isolated from Brazilian free wild birds.

Sci Rep

2023 May 5

de Lima Bessa G(#), Vitor RWA(#), Lobo LMS

136. SARS-CoV-2 intra-host diversity, antibody response, and disease severity after reinfection by the variant of concern Gamma in Brazil.

Sci Rep

2023 May 5

Naveca FG, Nascimento VA, Nascimento F

The rapid spread of the SARS-CoV-2 Variant of Concern (VOC) Gamma in Amazonas during early 2021 fueled a second large COVID-19 epidemic wave and raised concern about the potential role of reinfections. Very few cases of reinfection associated with the VOC Gamma have been reported to date, and their potential impact on clinical, immunological, and virological parameters remains largely unexplored. Here we describe 25 cases of SARS-CoV-2 reinfection in Brazil. SARS-CoV-2 genomic analysis confirmed that individuals were primo-infected with distinct viral lineages between March and December 2020 (B.1.1, B.1.1.28, B.1.1.33, B.1.195, and P.2) and reinfected with the VOC Gamma between 3 to 12 months after primo-infection. We found a similar mean cycle threshold (Ct) value and limited intra-host viral diversity in both primo-infection and reinfection samples. Sera of 14 patients tested 10-75 days after reinfection displayed detectable neutralizing antibodies (NAb) titers against SARS-CoV-2 variants that circulated before (B.1.*), during (Gamma), and after (Delta and Omicron) the second epidemic wave in Brazil. All individuals had milder or no symptoms after reinfection, and none required hospitalization. These findings demonstrate that individuals reinfected with the VOC Gamma may display relatively high RNA viral loads at the upper respiratory tract after reinfection, thus contributing to onward viral transmissions. Despite this, our study points to a low overall risk of severe Gamma reinfections, supporting that the abrupt increase in hospital admissions and deaths observed in Amazonas and other Brazilian states during the Gamma wave was mostly driven by primary infections. Our findings also indicate that most individuals analyzed developed a high anti-SARS-CoV-2 NAb response after reinfection that may provide some protection against reinfection or disease by different SARS-CoV-2 variants.

137. Characterization of ZmPMP3g function in drought tolerance of maize.

Sci Rep

2023 May 5

Lei L, Pan H, Hu HY

138. The temporal dynamics of emotion comparison depends on low-level attentional factors.

Sci Rep

2023 May 5

Dissegna A, Baldassi G, Murgia M

139. Feasibility study of the Nox-T3 device to detect swallowing and respiration pattern in neurologically impaired patients in the acute phase.

Sci Rep

2023 May 5

Theytaz F(#), Vuistiner A(#), Schweizer V

140. Multispectral versus texture features from ZiYuan-3 for recognizing on deciduous tree species with cloud and SVM models.

Sci Rep

2023 May 5

Liu X, Wang L, Liu X

141. Scaffold repositioning of spiro-acridine derivatives as fungi chitinase inhibitor by target fishing and in vitro studies.

Sci Rep

2023 May 5

de Oliveira Viana J, Silva E Souza E, Sbaraini N

142. Machine learning analysis predicts a person's sex based on mechanical but not thermal pain thresholds.

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2023 May 5

Lötsch J, Mayer B, Kringel D.

143. Children's affective involvement in early word learning.

Sci Rep

2023 May 5

Outters V, Hepach R, Behne T

144. Comparison of biomarkers of exposure among US adult smokers, users of electronic nicotine delivery systems, dual users and nonusers, 2018-2019.

Sci Rep

2023 May 5

Holt NM, Shiffman S, Black RA

145. NK cell marker gene-based model shows good predictive ability in prognosis and response to immunotherapies in hepatocellular carcinoma.

Sci Rep

2023 May 5

Li J(#), Li Y(#), Li F

146. A monopole antenna with cotton fabric material for wearable applications.

Sci Rep

2023 May 5

Ayd R Saad A, Hassan WM, Ibrahim AA.

147. Evaluating the ability of some natural phenolic acids to target the main protease and AAK1 in SARS COV-2.

Sci Rep

2023 May 5

Ghamry HI, Belal A, El-Ashrey MK

148. Effects of exogenous protease addition on fermentation and nutritive value of rehydrated corn and sorghum grains silages.

Sci Rep

2023 May 5

Roseira JPS, Pereira OG, da Silveira TC

149. Succinylation-associated lncRNA signature to predict the prognosis of colon cancer based on integrative bioinformatics analysis.

Sci Rep

2023 May 5

Zhang SM(#), Shen C(#), Gu J(#)

150. New, fast and cheap prediction tests for BRCA1 gene mutations identification in clinical samples.

Sci Rep

2023 May 5

Gajda-Walczak A, Potęga A, Kowalczyk A

151. Deep learning applied to EEG source-data reveals both ventral and dorsal visual stream involvement in holistic processing of social stimuli.

Sci Rep

2023 May 5

Borra D(#), Bossi F(#), Rivolta D

152. Metabolic profiles of lung adenocarcinoma via peripheral blood and diagnostic model construction.

Sci Rep

2023 May 5

Kim KS, Moon SW, Moon MH

153. A novel approach with a fuzzy sliding mode proportional integral control algorithm tuned by fuzzy method (FSMPIF).

Sci Rep

2023 May 5

Nguyen TA.

154. The prevalence and factors associated with obesity and hypertension in university academic staff: a cross-sectional study in Bangladesh.

Sci Rep

2023 May 5

Ali N, Ahmed S, Mahmood S

Obesity is a major risk factor for hypertension, type 2 diabetes and other morbidities. On the other hand, hypertension is a leading cause of cardiovascular disease. The presence of obesity in hypertensive persons increases cardiovascular risk and related mortality. Data on the prevalence of obesity and hypertension in academic staff in Bangladesh are scarce. This study aimed to determine the prevalence and factors associated with obesity and hypertension among university academic staff in Bangladesh. In total, 352 academic staff were enrolled in this study from two universities in Bangladesh. A pre-structured questionnaire was used to obtain data on anthropometric, demographic and lifestyle-related factors. Bivariate and multivariate logistic regression analyses were performed to assess the factors associated with obesity and hypertension. Overall, the prevalence of general and abdominal obesity and hypertension was 26.7%, 46.9% and 33.7%, respectively. Female staff had a significantly higher prevalence of both general and abdominal obesity (41% and 64.1%, respectively) than male staff (21.5% and 34.9%, respectively) (p < 0.001). In contrast, male staff had a higher prevalence of hypertension (36.9%) than female staff (25.6%)(p < 0.001). An increased prevalence of hypertension was found in the higher BMI and WC groups of the participants. The prevalence of general obesity, abdominal obesity and hypertension was higher in the 30-40 years, > 50 years and 41-50 years age groups, respectively. According to the regression analysis, female gender and inadequate physical activity were independently associated with general and abdominal obesity. On the other hand, increased age, BMI, WC, presence of diabetes and smoking showed a significant association with hypertension. In conclusion, the prevalence of obesity and hypertension was higher among university academic staff members in Bangladesh. Our findings suggest that comprehensive screening programs are needed to facilitate the diagnosis, control, and prevention of obesity and hypertension in high-risk population groups.

155. Performance aware shared memory hierarchy model for multicore processors.

Sci Rep

2023 May 5

Mohamed AM, Mubark N, Zagloul S.

156. Zero-shot transfer learned generic AI models for prediction of optimally ripe climacteric fruits.

Sci Rep

2023 May 5

Dutta J, Patwardhan M, Deshpande P

157. Impact of cholecystectomy on acute coronary syndrome according to metabolic condition: a nationwide population-based cohort study.

Sci Rep

2023 May 5

Chae W(#), Lee HS(#), Jo JH

158. Effect of pterygium on corneal astigmatism, irregularity and higher-order aberrations: a comparative study with normal fellow eyes.

Sci Rep

2023 May 5

Yoon CH, Seol BR, Choi HJ.

159. Heavy metal pollution levels and health risk assessment of dust storms in Jazmurian region, Iran.

Sci Rep

2023 May 5

Soleimani-Sardo M, Shirani M, Strezov V.

160. Trophic relationship between Salix flowers, Orthosia moths and the western barbastelle.

Sci Rep

2023 May 5

Apoznański G, Carr A, Gelang M

161. Female scent accelerates growth of juvenile male mice.

Sci Rep

2023 May 5

Zala SM, Church B, Potts WK

162. Pancreatic β-cell glutaminase 2 maintains glucose homeostasis under the condition of hyperglycaemia.

Sci Rep

2023 May 5

Deguchi-Horiuchi H, Suzuki S, Lee EY

Glutaminase 2 (GLS2), a master regulator of glutaminolysis that is induced by p53 and converts glutamine to glutamate, is abundant in the liver but also exists in pancreatic β-cells. However, the roles of GLS2 in islets associated with glucose metabolism are unknown, presenting a critical issue. To investigate the roles of GLS2 in pancreatic β-cells in vivo, we generated β-cell-specific Gls2 conditional knockout mice (Gls2 CKO), examined their glucose homeostasis, and validated the findings using a human islet single-cell analysis database. GLS2 expression markedly increased along with p53 in β-cells from control (RIP-Cre) mice fed a high-fat diet. Furthermore, Gls2 CKO exhibited significant diabetes mellitus with gluconeogenesis and insulin resistance when fed a high-fat diet. Despite marked hyperglycaemia, impaired insulin secretion and paradoxical glucagon elevation were observed in high-fat diet-fed Gls2 CKO mice. GLS2 silencing in the pancreatic β-cell line MIN6 revealed downregulation of insulin secretion and intracellular ATP levels, which were closely related to glucose-stimulated insulin secretion. Additionally, analysis of single-cell RNA-sequencing data from human pancreatic islet cells also revealed that GLS2 expression was elevated in β-cells from diabetic donors compared to nondiabetic donors. Consistent with the results of Gls2 CKO, downregulated GLS2 expression in human pancreatic β-cells from diabetic donors was associated with significantly lower insulin gene expression as well as lower expression of members of the insulin secretion pathway, including ATPase and several molecules that signal to insulin secretory granules, in β-cells but higher glucagon gene expression in α-cells. Although the exact mechanism by which β-cell-specific GLS2 regulates insulin and glucagon requires further study, our data indicate that GLS2 in pancreatic β-cells maintains glucose homeostasis under the condition of hyperglycaemia.

163. Reduced microbial diversity of the nasopharyngeal microbiome in household contacts with latent tuberculosis infection.

Sci Rep

2023 May 5

Ruiz-Tagle C, Ugalde JA, Naves R

164. Parallel dynamics in the yield of universal SARS-CoV-2 admission screening and population incidence.

Sci Rep

2023 May 5

Schreiber PW, Scheier T, Wolfensberger A

The majority of SARS-CoV-2 transmissions originates from either asymptomatic or presymptomatic individuals. To prevent unnoticed introduction of SARS-CoV-2, many hospitals have implemented universal admission screening during the COVID-19 pandemic. The present study aimed to investigate associations between results of an universal SARS-CoV-2 admission screening and public SARS-CoV-2 incidence. Over a study period of 44 weeks, all patients admitted to a large tertiary care hospital were tested for SARS-CoV-2 by polymerase chain reaction. SARS-CoV-2 positive patients were retrospectively categorized as symptomatic or asymptomatic at admission. Cantonal data were used to calculate weekly incidence rates per 100,000 inhabitants. We used regression models for count data to assess the association of the weekly cantonal incidence rate and the proportion of positive SARS-CoV-2 tests in the canton with (a) the proportion of SARS-CoV-2 positive individuals and (b) the proportion of asymptomatic SARS-CoV-2 infected individuals identified in universal admission screening, respectively. In a 44-week period, a total of 21,508 admission screenings were performed. SARS-CoV-2 PCR was positive in 643 (3.0%) individuals. In 97 (15.0%) individuals, the positive PCR reflected residual viral replication after recent COVID-19, 469 (72.9%) individuals had COVID-19 symptoms and 77 (12.0%) SARS-CoV-2 positive individuals were asymptomatic. Cantonal incidence correlated with the proportion of SARS-CoV-2 positive individuals [rate ratio (RR): 2.03 per 100 point increase of weekly incidence rate, 95%CI 1.92-2.14] and the proportion of asymptomatic SARS-CoV-2 positive individuals (RR: 2.40 per 100 point increase of weekly incidence rate, 95%CI 2.03-2.82). The highest correlation between dynamics in cantonal incidence and results of admission screening was observed at a lag time of one week. Similarly, the proportion of positive SARS-CoV-2 tests in the canton of Zurich correlated with the proportion of SARS-CoV-2 positive individuals (RR: 2.86 per log increase in the proportion of positive SARS-CoV-2 tests in the canton, 95%CI 2.56-3.19) and the proportion of asymptomatic SARS-CoV-2 positive individuals (RR: 6.50 per log increase in the proportion of positive SARS-CoV-2 tests in the canton, 95%CI 3.93-10.75) in admission screening. Around 0.36% of admission screenings were positive in asymptomatic patients. Admission screening results paralleled changes in population incidence with a brief lag.

165. People are curious about immoral and morally ambiguous others.

Sci Rep

2023 May 5

Wylie J, Gantman A.

166. Malaria, climate variability, and interventions: modelling transmission dynamics.

Sci Rep

2023 May 5

Beloconi A, Nyawanda BO, Bigogo G

167. The factors associated with mortality and progressive disease of nontuberculous mycobacterial lung disease: a systematic review and meta-analysis.

Sci Rep

2023 May 5

Hwang H, Lee JK, Heo EY

This systematic review and meta-analysis aimed to comprehensively evaluate the factors associated with mortality and progressive disease in NTM-LD patients. We conducted a literature search to identify the eligible studies, dated between January 1, 2007, and April 12, 2021. Forty-one studies with total 10,452 patients were included. The overall all-cause mortality rate was 20% (95% CI 17-24%). The overall rates of clinical and radiographic progressive disease were 46% (95% CI 39-53%) and 43% (95% CI 31-55%), respectively. Older age, male sex, history of TB, diabetes, chronic heart disease, malignancy, systemic immunosuppression, chronic liver disease, presence of cavity, consolidative radiologic features, acid-fast bacillus (AFB) smear positivity, hypoalbuminemia, anemia, increasing platelet count, high CRP, and high ESR were significantly associated with increased all-cause mortality, whereas increasing body mass index (BMI), hemoptysis, and treatment with rifamycin regimen (in M. xenopi) were significantly associated with decreased all-cause mortality in multivariable analysis. History of TB, Aspergillus co-infection, cough, increased sputum, weight loss, presence of cavity, and AFB smear positivity were significantly associated with increased clinical progression with treatment, while older age and low BMI were significantly associated with decreased clinical progression in multivariable analysis. Older age, interstitial lung disease, presence of cavity, consolidative radiologic feature, anemia, high CRP, and leukocytosis were significantly associated with increased radiographic progression after adjusting for covariates. Older age, history of tuberculosis, presence of cavity, consolidative radiologic features, AFB smear positivity, anemia, and high C-reactive protein were common significant factors associated with the all-cause mortality and clinical or radiographic progressive disease of NTM-LD. These factors are thought to directly affect NTM-LD related mortality. The future prediction models for the prognosis of NTM-LD should be established considering these factors.

168. Rapid and reliable re-design of miniaturized microwave passives by means of concurrent parameter scaling and intermittent local tuning.

Sci Rep

2023 May 5

Koziel S, Pietrenko-Dabrowska A.

169. Use of machine learning to assess the prognostic utility of radiomic features for in-hospital COVID-19 mortality.

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2023 May 5

Sun Y(#), Salerno S(#), He X

170. Inaccuracies of deterministic finite-element models of human middle ear revealed by stochastic modelling.

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2023 May 5

Ebrahimian A, Mohammadi H, Rosowski JJ

171. Denoising diffusion probabilistic models for 3D medical image generation.

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2023 May 5

Khader F, Müller-Franzes G, Tayebi Arasteh S

172. Association of cerebellar and pre-motor cortex gray matter density with subjective intoxication and subjective response following acute alcohol intake.

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2023 May 5

Stennett-Blackmon BA, Sevel L, Boissoneault J.

173. Inference in conditioned dynamics through causality restoration.

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2023 May 5

Braunstein A, Catania G, Dall'Asta L

174. Associations between cardiorespiratory fitness and cardiometabolic risk factors in children and adolescents with obesity.

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2023 May 5

Johansson L, Putri RR, Danielsson P

175. Plant-growth promoting activity of three fungal endophytes isolated from plants living in dehesas and their effect on Lolium multiflorum.

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2023 May 5

García-Latorre C, Rodrigo S, Marin-Felix Y

176. Robust online learning based on siamese network for ship tracking.

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2023 May 5

Hu Z, Shao J, Nie F

177. Novel hazards of waterpipe tobacco and the benefits of stop smoking in men, a prospective cohort study.

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2023 May 5

Kieu HD(#), Van Phan C(#), Tran HH

Waterpipe smoking is an emerging epidemic and a severe public health problem worldwide. Observational studies on the hazards of a specific new waterpipe tobacco product are timely needed. The objectives were to analyze how dangerous waterpipe tobacco smoking is on the causes of all mortality, including cancer, and how effective smoking cessation is for improving health. We analyzed the hazards of exclusive waterpipe smoking through a prospective cohort study in Northern Vietnam. We obtained exposure data on the smoking status of specific cigarette and waterpipe and smoking cessation histories from each study participant. The outcome includes deaths due to all causes. The cause of death for each case is determined based on medical records. HR (95%CI) was estimated using a Cox proportional-hazards-regression analysis for overall mortality and all cancers. The ever-cigarette smoking group as the reference group, the exclusive waterpipe smoking group had a statistical increase in the risk for overall mortality HR (95% CI): 1.63 (1.32, 2.00), and all cancers HR (95%CI): 1.67 (1.18, 2.38). The risk of death increased statistically in the group of waterpipe smoking over 20 years for overall mortality HR (95%CI): 1.82 (1.45, 2.29), and all cancers HR (95%CI): 1.91 (1.27, 2.88). After stopping smoking, the risk of death decreased steadily. The risk of death was reduced by 41% for overall mortality HR (95%CI): 0.59 (0.39, 0.89), and 74% for death from cancers HR (95%CI): 0.26 (0.08, 0.83) after ten years or longer of cessation. Life expectancy was shortened by more than six years for the group of exclusive waterpipe smokers compared to non-smokers. This study found new novel hazards of exclusive waterpipe tobacco smoking. The findings are scientific evidence for developing strategies, policies, and budget allocations to control this novel tobacco product and promote cessation to improve life expectancy.

178. An evolutionary game study of cockroach control strategies in residential households.

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2023 May 5

Li Q(#), Liu M(#), Liu T

179. Deletion of MIF gene from live attenuated LdCen(-/-) parasites enhances protective CD4(+) T cell immunity.

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2023 May 5

Fiuza JA(#), Gannavaram S(#), Gaze ST

180. Modifications of peripheral perfusion in patients with vasopressor-dependent septic shock treated with polymyxin B-direct hemoperfusion.

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2023 May 5

Sekino M(#), Murakami Y(#), Sato S

181. Analysis of PPI networks of transcriptomic expression identifies hub genes associated with Newcastle disease virus persistent infection in bladder cancer.

Sci Rep

2023 May 5

Ahmad U, Abdullah S, Chau M

Bladder cancer cells can acquire persistent infection of oncolytic Newcastle disease virus (NDV) but the molecular mechanism(s) remain unelucidated. This poses a major barrier to the effective clinical translation of oncolytic NDV virotherapy of cancers. To improve our understanding of the molecular mechanism(s) associated with the development of NDV persistent infection in bladder cancer, we used mRNA expression profiles of persistently infected bladder cancer cells to construct PPI networks. Based on paths and modules in the PPI network, the bridges were found mainly in the upregulated mRNA-pathways of p53 signalling, ECM-receptor interaction, and TGF-beta signalling and downregulated mRNA-pathways of antigen processing and presentation, protein processing in endoplasmic reticulum, completement and coagulation cascades in persistent TCCSUPPi cells. In persistent EJ28Pi cells, connections were identified mainly through upregulated mRNA-pathways of renal carcinoma, viral carcinogenesis, Ras signalling and cell cycle and the downregulated mRNA-pathways of Wnt signalling, HTLV-I infection and pathways in cancers. These connections were mainly dependent on RPL8-HSPA1A/HSPA4 in TCCSUPPi cells and EP300, PTPN11, RAC1-TP53, SP1, CCND1 and XPO1 in EJ28Pi cells. Oncomine validation showed that the top hub genes identified in the networks that include RPL8, THBS1, F2 from TCCSUPPi and TP53 and RAC1 from EJ28Pi are involved in the development and progression of bladder cancer. Protein-drug interaction networks identified several putative drug targets that could be used to disrupt the linkages between the modules and prevent bladder cancer cells from acquiring NDV persistent infection. This novel PPI network analysis of differentially expressed mRNAs of NDV persistently infected bladder cancer cell lines provide an insight into the molecular mechanisms of NDV persistency of infection in bladder cancers and the future screening of drugs that can be used together with NDV to enhance its oncolytic efficacy.

182. The effects of muscle mass and quality on mortality of patients with acute kidney injury requiring continuous renal replacement therapy.

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2023 May 5

Jung J(#), Lee J(#), Lim JH

183. Virus infection of phytoplankton increases average molar mass and reduces hygroscopicity of aerosolized organic matter.

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2023 May 5

Diaz BP, Gallo F, Moore RH

184. Assessment of the impacts of climat change on water supply system pipe failures.

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2023 May 5

Fan X, Zhang X, Yu A

185. The protective effects of electroacupuncture on intestinal barrier lesions in IBS and UC model.

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2023 May 4

Liu S(#), Huang Q(#), Huang Q(#)

186. Diagnosis of thyroid micronodules on ultrasound using a deep convolutional neural network.

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2023 May 4

Rho M, Chun SH, Lee E

187. L-Lactate treatment by photosynthetic cyanobacteria expressing heterogeneous L-lactate dehydrogenase.

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2023 May 4

Kato Y, Inabe K, Haraguchi Y

188. A clinical study of the correlation between metabolic-associated fatty liver disease and coronary plaque pattern.

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2023 May 4

Zhang Z, Zheng M, Lei H

Nonalcoholic fatty liver disease (NAFLD) is the hepatic manifestation of metabolic syndrome (MetS) and has been correlated with coronary atherosclerosis (CAS). Since NAFLD was renamed metabolic-associated fatty liver disease(MAFLD) in 2020, no studies have evaluated the correlation between MAFLD and CAS. The aim of this study was to evaluate the relationship between MAFLD and CAS. A total of 1330 patients underwent continuous coronary computed tomography angiography (CCTA) and abdominal ultrasound as part of a routine physical examination. Ultrasonography was used to assess fatty liver, and CCTA was used to assess coronary artery plaques, degree of stenosis, and diseased blood vessels. Univariate and multivariate logistic regression analyses were performed with plaque type and degree of stenosis as dependent variables and MAFLD and traditional cardiovascular risk factors as independent variables to analyze the correlation between MAFLD and CAS. Among the 1164 patients, 680 (58.4%) were diagnosed with MAFLD through a combination of ultrasound and auxiliary examinations. Compared with the non-MAFLD group, the MAFLD group had more cardiovascular risk factors,and the MAFLD group had more likely to have coronary atherosclerosis, coronary stenosis and multiple coronary artery stenosis.In the univariate logistic regression, MAFLD was significantly correlated with overall plaque, calcified plaques, noncalcified plaques, mixed plaques,and significant stenosis in the coronary arteries.(p < 0.05). After adjusting for cardiovascular risk factors , MAFLD was correlated with noncalcified plaques (1.67; 95% confidence interval (CI) 1.15-2.43; p = 0.007) and mixed plaques (1.54; 95% CI 1.10-2.16; p = 0.011). In this study, MAFLD group had more cardiovascular risk factors, MAFLD was correlated with coronary atherosclerosis,and significant stenosis.Further study found independent associations between MAFLD and noncalcified plaques and mixed plaques, which suggest a clinically relevant link between MAFLD and coronary atherosclerosis.

189. Association between ultra-processed foods intake with lipid profile: a cross-sectional study.

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2023 May 4

Nouri M, Eskandarzadeh S, Makhtoomi M

190. Mechanism-based and computational modeling of hydrogen sulfide biogenesis inhibition: interfacial inhibition.

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2023 May 4

Le Corre L, Padovani D.

191. Visual tracking of viral infection dynamics reveals the synergistic interactions between cucumber mosaic virus and broad bean wilt virus 2.

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2023 May 4

Kwon MJ, Kwon SJ, Kim MH

192. Passive limb training modulates respiratory rhythmic bursts.

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2023 May 4

Apicella R, Taccola G.

193. Metabolic profile of complete spinal cord injury in pons and cerebellum: A 3T 1H MRS study.

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2023 May 4

Richter JK, Vallesi V, Zölch N

194. Antiproliferative effects of mitochondria-targeted N-acetylcysteine and analogs in cancer cells.

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2023 May 4

Cheng G, Hardy M, Kalyanaraman B.

195. Green synthesis and characterization of iron oxide nanoparticles for the removal of heavy metals (Cd(2+) and Ni(2+)) from aqueous solutions with Antimicrobial Investigation.

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2023 May 4

Mohamed A, Atta RR, Kotp AA

196. Foreign stingers: South American freshwater river stingrays Potamotrygon spp. established in Indonesia.

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2023 May 4

Jerikho R, Akmal SG, Hasan V

197. Large scale sequence alignment via efficient inference in generative models.

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2023 May 4

Mongia M(#), Shen C(#), Davoodi AG

198. Nationwide patterns of hydroxychloroquine dosing and monitoring of retinal toxicity in patients with systemic lupus erythematosus.

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2023 May 4

Lee JE(#), Nam DR(#), Sung YK

199. A data-driven approach to quantify disparities in power outages.

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2023 May 4

Bhattacharyya A, Hastak M.

200. Prevalence and risk factors of burden among caregivers of older emergency department patients.

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2023 May 4

Zaalberg T, Barten DG, van Heugten CM

201. Efficient MIR crosstalk reduction based on silicon-on-calcium fluoride platform with Ge/Si strip arrays.

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2023 May 4

Elgammal NM, Younis BM, Gaafar MA

202. Therapeutic effects of clonazepam in patients with burning mouth syndrome and various symptoms or psychological conditions.

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2023 May 4

Shin HI, Bang JI, Kim GJ

203. Exercise with a wearable hip-assist robot improved physical function and walking efficiency in older adults.

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2023 May 4

Lee SH, Kim J, Lim B

204. Fishery resource management with migratory prey harvesting in two zones- delay and stochastic approach.

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2023 May 4

Niranjan H, Srinivas MN, Murty AVSN

205. The potential of HEART score to detect the severity of coronary artery disease according to SYNTAX score.

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2023 May 4

Salimi A, Zolghadrasli A, Jahangiri S

206. Out-of-plane polarization reversal and changes in in-plane ferroelectric and ferromagnetic domains of multiferroic BiFe(0.9)Co(0.1)O(3) thin films by water printing.

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2023 May 4

Itoh T, Shigematsu K, Nishikubo T

207. Continued fractions and the Thomson problem.

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2023 May 4

Moscato P, Haque MN, Moscato A.

208. Watercraft decontamination practices to reduce the viability of aquatic invasive species implicated in overland transport.

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2023 May 4

Mohit S, Johnson TB, Arnott SE.

209. Sentiments analysis of fMRI using automatically generated stimuli labels under naturalistic paradigm.

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2023 May 4

Mahrukh R, Shakil S, Malik AS.

210. Longitudinal surveillance of serum titanium ion levels in patients with indigenous 3D printed total temporomandibular joint replacement.

Sci Rep

2023 May 4

Khandelwal G, Roychoudhury A, Bhutia O

211. Distinct mutational pattern of T-cell large granular lymphocyte leukemia combined with pure red cell aplasia: low mutational burden of STAT3.

Sci Rep

2023 May 4

Park S, Yun J, Choi SY

212. Profiling of adrenal corticosteroids in blood and local tissues of mice during chronic stress.

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2023 May 4

Vagnerová K, Jágr M, Mekadim C

213. KIF2C accelerates the development of non-small cell lung cancer and is suppressed by miR-186-3p via the AKT-GSK3β-β-catenin pathway.

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2023 May 4

Guo J(#), Zhang W(#), Sun L

214. Investigating the effects of wind loading on three dimensional tree models using numerical simulation with implications for urban design.

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2023 May 4

Amani-Beni M, Tabatabaei Malazi M, Dehghanian K

215. Using single nucleotide polymorphism array for prenatal diagnosis in a large multicenter study in Southern China.

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2023 May 4

Cai M(#), Lin N(#), Guo N

216. Integrated gene expression profiles reveal a transcriptomic network underlying the thermogenic response in adipose tissue.

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2023 May 4

Rodó J, Garcia M, Casana E

217. Conceptual and quantitative categorization of wave-induced flooding impacts for pedestrians and assets in urban beaches.

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2023 May 4

Garzon JL, Ferreira Ó, Reis MT

218. Validation of immunoassays for the Chlamydia trachomatis antigen Pgp3 using a chimeric monoclonal antibody.

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2023 May 4

Goodhew B, Tang X, Goldstein J

219. Improved PVC/ZnO Nanocomposite Insulation for High Voltage and High Temperature Applications.

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2023 May 4

Faiza, Khattak A, Alahmadi AA

220. Voice disorder classification using convolutional neural network based on deep transfer learning.

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2023 May 4

Peng X(#), Xu H(#), Liu J

221. Blood unconjugated bilirubin and tacrolimus are negative predictors of specific cellular immunity in kidney transplant recipients after SAR-CoV-2 inactivated vaccination.

Sci Rep

2023 May 4

Zhang L(#), Yang J(#), Deng M(#)

222. 2-Oxoglutarate contributes to the effect of foliar nitrogen on enhancing drought tolerance during flowering and grain yield of soybean.

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2023 May 4

Gai Z(#), Zhang M(#), Zhang P

223. Treatment of broad-based intracranial aneurysms with the LVIS EVO stent: a retrospective observational study at two centers with short- and medium-term follow-up.

Sci Rep

2023 May 4

Maurer CJ, Berlis A, Maus V

224. Programmed death-ligand 1 expression and overall survival in Thai patients with gastric cancer.

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2023 May 4

Chitapanarux T, Gumrai P, Kongkarnka S

225. Arterial stiffness and the non-dipping pattern in type 1 diabetes males with and without erectile dysfunction.

Sci Rep

2023 May 4

Kulecki M(#), Naskret D(#), Kaminski M

226. Comparative and phylogenetic analysis of the complete chloroplast genomes of six Polygonatum species (Asparagaceae).

Sci Rep

2023 May 4

Zhang D, Ren J, Jiang H

Polygonatum Miller belongs to the tribe Polygonateae of Asparagaceae. The horizontal creeping fleshy roots of several species in this genus serve as traditional Chinese medicine. Previous studies have mainly reported the size and gene contents of the plastomes, with little information on the comparative analysis of the plastid genomes of this genus. Additionally, there are still some species whose chloroplast genome information has not been reported. In this study, the complete plastomes of six Polygonatum were sequenced and assembled, among them, the chloroplast genome of P. campanulatum was reported for the first time. Comparative and phylogenetic analyses were then conducted with the published plastomes of three related species. Results indicated that the whole plastome length of the Polygonatum species ranged from 154,564 bp (P. multiflorum) to 156,028 bp (P. stenophyllum) having a quadripartite structure of LSC and SSC separated by two IR regions. A total of 113 unique genes were detected in each of the species. Comparative analysis revealed that gene content and total GC content in these species were highly identical. No significant contraction or expansion was observed in the IR boundaries among all the species except P. sibiricum1, in which the rps19 gene was pseudogenized owing to incomplete duplication. Abundant long dispersed repeats and SSRs were detected in each genome. There were five remarkably variable regions and 14 positively selected genes were identified among Polygonatum and Heteropolygonatum. Phylogenetic results based on chloroplast genome strongly supported the placement of P. campanulatum with alternate leaves in sect. Verticillata, a group characterized by whorled leaves. Moreover, P. verticillatum and P. cyrtonema were displayed as paraphyletic. This study revealed that the characters of plastomes in Polygonatum and Heteropolygonatum maintained a high degree of similarity. Five highly variable regions were found to be potential specific DNA barcodes in Polygonatum. Phylogenetic results suggested that leaf arrangement was not suitable as a basis for delimitation of subgeneric groups in Polygonatum and the definitions of P. cyrtonema and P. verticillatum require further study.

227. Influence of load partial factors adjustment on reliability design of RC frame structures in China.

Sci Rep

2023 May 4

Cheng K, Weng G, Cheng Z.

The partial factor method has been widely used in building design and the partial factors to ensure the safety of structures are specified in the adopted codes. The load partial factors in the design expressions have been increased in the lasted code in China, which leads to theoretically increment in reliability and a growth in the consumption of construction materials. However, the influence of load partial factors adjustment on design of building structures arises different points among scholars. Some believe that it has a great impact on the design, some think the influence is small. This makes designers have doubts in the safety of structures and investors are also confused about the cost. In order to illustrate the influence of load partial factor adjustment on safety level and material consumption of RC (Reinforced Concrete) frame structures, reliability analysis and material consumption analysis are performed using First Order Reliability Method (FORM). The approach is carried out according to the load partial factors in Chinese codes of (GB50153-2008) and (GB50068-2018), respectively. Then, the influence of load partial factors adjustment is demonstrated with a case design of RC frame structures with different load partial factors in codes. The results show that the partial factor has a noticeable influence on the reliability index. The adjustment of load partial factors in design leads to an increase of the reliability index, which is about 8-16%. The increase of material consumption used in RC structures is about 0.75-6.29%. And the case indicated that the adjustment of load partial factors mainly result in the increase of reinforcement consumption, while have little effect on the concrete consumption. This study provides an analytical and conclusive insight into the influence of load partial factor adjustment on safety level and material consumption, which is can be applied to a wide range of structures.

228. A Fano-resonance plasmonic assembly for broadband-enhanced coherent anti-Stokes Raman scattering.

Sci Rep

2023 May 4

Zhang Y, Lu M, Zhu Z

229. Study of the disintegration of loess modified with fly ash and Roadyes.

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2023 May 4

Li H, Yang M, Guo X.

The disintegration property of loess is the wetting and subsequent disintegration of loess in water, which is generally an important index for resistance to erosion and disintegration of wet loess slopes and foundations. In this study, a disintegration instrument is developed in this laboratory and used to study the disintegration properties of fly ash-modified loess in foundations and Roadyes-modified loess in subgrades. Disintegration tests are used to compare samples of loess modified with different amounts of fly ash and Roadyes, different water contents and different dry densities; the influence of fly ash and Roadyes content on the disintegration of modified loess is analyzed. The differences in disintegration properties between the pure loess and modified loess are compared to explore the evolution of disintegration properties of modified loess and the optimal incorporation levels of fly ash and Roadyes. The experimental results show that the incorporation of fly ash reduces the disintegration of loess, while the incorporation of Roadyes likewise decreases the disintegration of loess. The disintegration of the loess modified with the two curing agents is better than that of the pure loess and loess mixed with a single curing agent; the optimal incorporation levels are 15% fly ash and 0.5‰ Roadyes. Comparing the evolution of the disintegration curves of samples of loess with different modifications shows is a linear relationship between time and amount of disintegration for pure loess and Roadyes-modified loess. Thus, a linear disintegration model is established in which the parameter P is the disintegration rate. According to the exponential relationship between time and amount of disintegration of fly ash-modified loess and loess modified with both fly ash and Roadyes, an exponential disintegration model is established in which the water stability parameter Q affects the strong and weak disintegration of the modified loess. The relationship between the water stability of the loess (modified with added fly ash and Roadyes) in water and the initial water content and dry density is analyzed. The water stability of the loess first increases and then decreases with increasing initial water content and gradually increases with increasing dry density. When the sample density is the maximum dry density, the sample has the best water stability. These research results provide a basis for the application of loess modified with added fly ash and Roadyes.

230. SproutAngio: an open-source bioimage informatics tool for quantitative analysis of sprouting angiogenesis and lumen space.

Sci Rep

2023 May 4

Beter M, Abdollahzadeh A(#), Pulkkinen HH(#)

231. Sediment resuspension due to internal solitary waves of elevation in the Messina Strait (Mediterranean Sea).

Sci Rep

2023 May 4

La Forgia G, Droghei R, Pierdomenico M

232. Self-absorption correction on 2D X-ray fluorescence maps.

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2023 May 4

Ge M, Yan H, Huang X

233. Comparison of the forward and sideways locomotor patterns in children with Cerebral Palsy.

Sci Rep

2023 May 4

Cappellini G, Sylos-Labini F, Avaltroni P

Switching locomotion direction is a common task in daily life, and it has been studied extensively in healthy people. Little is known, however, about the locomotor adjustments involved in changing locomotion direction from forward (FW) to sideways (SW) in children with cerebral palsy (CP). The importance of testing the ability of children with CP in this task lies in the assessment of flexible, adaptable adjustments of locomotion as a function of the environmental context. On the one hand, the ability of a child to cope with novel task requirements may provide prognostic cues as to the chances of modifying the gait adaptively. On the other hand, challenging the child with the novel task may represent a useful rehabilitation tool to improve the locomotor performance. SW is an asymmetrical locomotor task and requires a differential control of right and left limb muscles. Here, we report the results of a cross-sectional study comparing FW and SW in 27 children with CP (17 diplegic, 10 hemiplegic, 2-10 years) and 18 age-matched typically developing (TD) children. We analyzed gait kinematics, joint moments, EMG activity of 12 pairs of bilateral muscles, and muscle modules evaluated by factorization of EMG signals. Task performance in several children with CP differed drastically from that of TD children. Only 2/3 of children with CP met the primary outcome, i.e. they succeeded to step sideways, and they often demonstrated attempts to step forward. They tended to rotate their trunk FW, cross one leg over the other, flex the knee and hip. Moreover, in contrast to TD children, children with CP often exhibited similar motor modules for FW and SW. Overall, the results reflect developmental deficits in the control of gait, bilateral coordination and adjustment of basic motor modules in children with CP. We suggest that the sideways (along with the backward) style of locomotion represents a novel rehabilitation protocol that challenges the child to cope with novel contextual requirements.

234. The SciQA Scientific Question Answering Benchmark for Scholarly Knowledge.

Sci Rep

2023 May 4

Auer S, Barone DAC, Bartz C

235. Study on web pillar failure mechanism during auger mining and its associated risk assessment.

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2023 May 4

Jiang J, Sun J, Wang D

236. Green synthesis, characterization, and biological evaluation of gold and silver nanoparticles using Mentha spicata essential oil.

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2023 May 4

Moosavy MH, de la Guardia M, Mokhtarzadeh A

Green synthesis of bioactive nanoparticles (NPs) is getting more attractive in various fields of science including the food industry. This study investigates the green synthesizing and characterization of gold NPs (AuNPs) and silver NPs (AgNPs) produced using Mentha spicata L. (M. spicata) essential oil as well as their antibacterial, antioxidant, and in vitro cytotoxic effects. The essential oil was mixed with both Chloroauric acid (HAuCl4) and aqueous silver nitrate (AgNO3) solutions separately and incubated at room temperature for 24 h. The chemical composition of the essential oil was identified by gas chromatography coupled with a mass spectrometer detector (GC-MS). Au and Ag nanoparticles were characterized using UV-Vis spectroscopy, transmission electron microscopy, scanning electron microscopy, dynamic light scattering (DLS), X-ray diffraction (XRD) and Fourier transform infrared (FTIR). The cytotoxicity of both types of nanoparticles was evaluated using MTT assay on cancerous HEPG-2cell line by exposing them to various concentrations of both NPs for 24 h. The antimicrobial effect was evaluated by the well-diffusion technique. The antioxidant effect was determined by DPPH and ABTS tests. According to the results of GC-MS analysis, 18 components were identified, including carvone (78.76%) and limonene (11.50%). UV-visible spectroscopy showed a strong absorption peak of 563 nm and 485 nm, indicating the formation of Au NPs and Ag NPs, respectively. TEM and DLS demonstrated that AuNPs and AgNPs were predominantly spherical shaped with average sizes of 19.61 nm and 24 nm, respectively. FTIR analysis showed that biologically active compounds such as monoterpenes could assist in the formation and stabilization of both types of NPs. Additionally, XRD provided more accurate results, revealing a nano-metal structure. Silver nanoparticles exhibited better antimicrobial activity against the bacteria than AuNPs. Zones of inhibition ranging 9.0-16.0 mm were recorded for the AgNPs, while zones of 8.0-10.33 mm were observed AuNPs. In the ABTS assay, the AuNPs and AgNPs showed a dose-dependent activity and synthesized nanoparticles exhibited higher antioxidant activity than MSEO in both assays. Mentha spicata essential oil can be successfully used for the green production of Au NPs and Ag NPs. Both green synthesized NPs show antibacterial, antioxidant, and in vitro cytotoxic activity.

237. Transcriptomic analysis of glutamate-induced HT22 neurotoxicity as a model for screening anti-Alzheimer's drugs.

Sci Rep

2023 May 4

Prasansuklab A, Sukjamnong S, Theerasri A

238. Unrevealing tunable resonant excitons and correlated plasmons and their coupling in new amorphous carbon-like for highly efficient photovoltaic devices.

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2023 May 4

Darminto D, Asih R, Priyanto B

239. Inadequate dietary diversity practices and associated factors among postpartum mothers in Gambella town, Southwest Ethiopia.

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2023 May 4

Teferi T, Endalk G, Ayenew GM

The shortage of diversified diets in lactating postpartum mothers is a severe problem in developing countries. The promotion of diverse diets is important to improving micronutrient nourishment and adequate energy intake for lactating mothers. To date, there is limited evidence regarding inadequate dietary diversity practices among lactating postpartum mothers in Gambella region. The study is aimed to determine inadequate dietary diversity practice and associated factors among lactating postpartum mothers in Gambella city, southwest Ethiopia. Mixed methods were employed on 407 randomly selected lactating postpartum mothers and 15 purposively selected key informants from February 28 to March 24, 2021. A pre-tested questionnaire and interview guide were used for data collection. Data were analyzed using Statistical Package for the Social Sciences version 21 software. Binary logistic regression models were used to determine the associated factors of dietary diversity. Qualitative data were analyzed manually through a thematic approach. The prevalence of inadequate dietary diversity practice was 60.2%. Having no education (AOR = 3.74, 95% CI: 1.18, 11.88), employed women(AOR = 0.37, 95% CI: 0.18, 0.75), meal frequency < 3 meals (AOR = 2.92, 95% CI: 1.04, 8.71), time taken to market > 30 min (AOR = 4.20, 95% CI: 2.01, 8.76), not received nutrition education (AOR = 2.0, 95% CI:1.09, 3.68), having home gardening (AOR = 0.32, 95% CI: 0.18, 0.57) and having big animals (AOR = 0.12, 95% CI: 0.05, 0.29) were significant factors of inadequate dietary diversity practice. Diet habits, food taboos, low social status of women in ownership of household assets, low family support, order of feeding, child preference for resource distribution in a polygamous family, and health care provider's advice were the main mentioned reasons for inadequate dietary diversity practices. The prevalence of inadequate dietary diversity practices were high compared to previous studies. Having no education, employed women, meal frequency < 3 meals, time taken to market > 30 min, not receiving nutrition education, having a home garden, and having big animals were significant factors of inadequate dietary diversity practice. Nutrition intervention focused on nutrition education to increase meal frequency should be provided for lactating postpartum mothers to improve inadequate dietary diversity practices.

240. Profile of sleep disturbances in patients with recurrent depressive disorder or bipolar affective disorder in a tertiary sleep disorders service.

Sci Rep

2023 May 31

Drakatos P(#), O'Regan D(#), Liao Y

241. Feasibility of spinal cord imaging at 7 T using rosette trajectory with magnetization transfer preparation and compressed sensing.

Sci Rep

2023 May 31

Mahmud SZ, Denney TS, Bashir A.

242. Extracellular vesicles secreted by Brugia malayi microfilariae modulate the melanization pathway in the mosquito host.

Sci Rep

2023 May 31

Loghry HJ, Kwon H, Smith RC

243. Portable, high speed blood flow measurements enabled by long wavelength, interferometric diffuse correlation spectroscopy (LW-iDCS).

Sci Rep

2023 May 31

Robinson MB, Renna M, Ozana N

244. Somatostatin-expressing interneurons modulate neocortical network through GABAb receptors in a synapse-specific manner.

Sci Rep

2023 May 31

Kanigowski D, Bogaj K, Barth AL

245. Clustering of clinical and echocardiographic phenotypes of covid-19 patients.

Sci Rep

2023 May 31

Shpigelman E(#), Hochstadt A(#), Coster D

246. Effects of normal aging on the mouse retina assessed by full-field flash and flicker electroretinography.

Sci Rep

2023 May 31

Park JC, Persidina O, Balasubramanian G

247. Assisted damage closure and healing in soft robots by shape memory alloy wires.

Sci Rep

2023 May 31

Kashef Tabrizian S, Terryn S, Cornellà AC

248. Next-generation RNA sequencing elucidates transcriptomic signatures of pathophysiologic nerve regeneration.

Sci Rep

2023 May 31

Warner WS, Stubben C, Yeoh S

249. A beamline to control longitudinal phase space whilst transporting laser wakefield accelerated electrons to an undulator.

Sci Rep

2023 May 31

Dewhurst KA, Muratori BD, Brunetti E

250. Miscibility and ternary diagram of aqueous polyvinyl alcohols with different degrees of saponification.

Sci Rep

2023 May 31

Kim J(#), Ishikawa S(#), Naito M

251. Efficient photocatalytic degradation of organic pollutants over TiO(2) nanoparticles modified with nitrogen and MoS(2) under visible light irradiation.

Sci Rep

2023 May 31

El Sharkawy HM, Shawky AM, Elshypany R

252. A straightforward method using the sign of the piezoelectric coefficient to identify the ferroelectric switching mechanism.

Sci Rep

2023 May 31

Ishibashi S, Kumai R, Horiuchi S.

253. Evaluation of lung adverse events with nivolumab using the spontaneous reporting system in Japan.

Sci Rep

2023 May 31

Kanbayashi Y, Shimizu T, Kojima A

254. Estimating urban spatial structure based on remote sensing data.

Sci Rep

2023 May 31

Kii M, Tamaki T, Suzuki T

255. Controlling fluidic oscillator flow dynamics by elastic structure vibration.

Sci Rep

2023 May 31

Loe IA, Zheng T, Kotani K

256. The largest prehistoric mound in Europe is the Bronze-Age Hill of Udine (Italy) and legend linked its origin to Attila the Hun.

Sci Rep

2023 May 31

Fontana A, Vinci G, Ronchi L

257. Design and evaluation of a skin-on-a-chip pumpless microfluidic device.

Sci Rep

2023 May 31

Mohamadali M, Ghiaseddin A, Irani S

258. Mother-to-child transmission of SARS-CoV-2 infection in high-income countries: a systematic review and meta-analysis of prospective observational studies.

Sci Rep

2023 May 31

Morniroli D(#), Vizzari G(#), Tosi M

259. Necrosulfonamide exerts neuroprotective effect by inhibiting necroptosis, neuroinflammation, and α-synuclein oligomerization in a subacute MPTP mouse model of Parkinson's disease.

Sci Rep

2023 May 31

Leem YH, Kim DY, Park JE

260. Prognostic value of peak work rate indexed by left ventricular diameter.

Sci Rep

2023 May 31

Eklund Gustafsson C, Ekström M, Ugander M

261. Femtosecond laser-induced nano- and microstructuring of Cu electrodes for CO(2) electroreduction in acetonitrile medium.

Sci Rep

2023 May 31

Gnilitskyi I, Bellucci S, Marrani AG

262. Improving the efficiency of RMSProp optimizer by utilizing Nestrove in deep learning.

Sci Rep

2023 May 31

Elshamy R, Abu-Elnasr O, Elhoseny M

263. A new bio-inspired metaheuristic algorithm for solving optimization problems based on walruses behavior.

Sci Rep

2023 May 31

Trojovský P, Dehghani M.

264. Effects of two years of physically active lessons on cognitive indicators in children.

Sci Rep

2023 May 31

Oliveira DN, Silva ECM, Barboza LLS

265. A fast methodology for generating skeletal FEM with detailed human geometric features based on CPD and RBF algorithms.

Sci Rep

2023 May 31

Yuan Q, Jiang B, Zhu X

266. Modulation of tumor immune microenvironment by TAS-115, a multi-receptor tyrosine kinase inhibitor, promotes antitumor immunity and contributes anti-PD-1 antibody therapy.

Sci Rep

2023 May 31

Shibutani T, Goto R, Miyazaki I

267. Ensemble heterogeneity mimics ageing for endosomal dynamics within eukaryotic cells.

Sci Rep

2023 May 31

Korabel N, Taloni A, Pagnini G

268. Comparative genomics of two Vietnamese Helicobacter pylori strains, CHC155 from a non-cardia gastric cancer patient and VN1291 from a duodenal ulcer patient.

Sci Rep

2023 May 31

Phuc BH, Tuan VP, Binh TT

269. C-reactive protein/albumin ratio is the most significant inflammatory marker in unresectable pancreatic cancer treated with FOLFIRINOX or gemcitabine plus nab-paclitaxel.

Sci Rep

2023 May 31

Shirakawa T, Makiyama A, Shimokawa M

270. Comparative genome features and secondary metabolite biosynthetic potential of Kutzneria chonburiensis and other species of the genus Kutzneria.

Sci Rep

2023 May 31

Chanama M, Prombutara P, Chanama S.

271. Pilot evaluation of a single oral fecal microbiota transplantation for canine atopic dermatitis.

Sci Rep

2023 May 31

Sugita K, Shima A, Takahashi K

272. Panoramic dental tomosynthesis imaging by use of CBCT projection data.

Sci Rep

2023 May 31

Kwon T, Choi DI, Hwang J

273. An electrochemical sensor for the detection of arsenic using nanocomposite-modified electrode.

Sci Rep

2023 May 31

Hamid Kargari S, Ahour F, Mahmoudian M.

274. Investigating associations between physical activity, stress experience, and affective wellbeing during an examination period using experience sampling and accelerometry.

Sci Rep

2023 May 31

Hachenberger J, Teuber Z, Li YM

275. Engineering nanowires in bacteria to elucidate electron transport structural-functional relationships.

Sci Rep

2023 May 31

Myers B, Catrambone F, Allen S

276. Proteomics and secreted lipidomics of mouse-derived bone marrow cells exposed to a lethal level of ionizing radiation.

Sci Rep

2023 May 31

Tatara Y, Monzen S.

277. Physical fitness of primary school children differs depending on their timing of school enrollment.

Sci Rep

2023 May 31

Teich P, Fühner T, Granacher U

Previous research has shown that children who were enrolled to school according to the legal key date (i.e., keyage children, between eight and nine years in third grade) exhibited a linear physical fitness development in the ninth year of life. In contrast, children who were enrolled with a delay (i.e., older-than-keyage children [OTK], between nine and ten years in third grade) exhibited a lower physical fitness compared to what would be expected for their age. In these studies, cross-sectional age differences within third grade and timing of school enrollment were confounded. The present study investigated the longitudinal development of keyage and OTK children from third to fifth grade. This design also afforded a comparison of the two groups at the same average chronological age, that is a dissociation of the effects of timing of school enrollment and age. We tested six physical fitness components: cardiorespiratory endurance, coordination, speed, power of lower and upper limbs, and static balance. 1502 children (i.e., 1206 keyage and 296 OTK children) from 35 schools were tested in third, fourth, and fifth grade. Except for cardiorespiratory endurance, both groups developed from third to fourth and from fourth to fifth grade and keyage children outperformed OTK children at the average ages of 9.5 or 10.5 years. For cardiorespiratory endurance, there was no significant gain from fourth to fifth grade and keyage and OTK children did not differ significantly at 10.5 years of age. One reason for a delayed school enrollment could be that a child is (or is perceived as) biologically younger than their chronological age at the school entry examination, implying a negative correlation between chronological and biological age for OTK children. Indeed, a simple reflection of chronological age brought the developmental rate of the chronologically youngest OTK children in line with the developmental rate observed for keyage children, but did not eliminate all differences. The mapping of chronological and biological age of OTK children and other possible reasons for lower physical fitness of OTK children remain a task for future research.

278. Synergistic cytotoxic effects of an extremely low-frequency electromagnetic field with doxorubicin on MCF-7 cell line.

Sci Rep

2023 May 31

Ramazi S, Salimian M, Allahverdi A

279. A sustainable approach for the degradation kinetics study and stability assay of the SARS-CoV-2 oral antiviral drug Molnupiravir.

Sci Rep

2023 May 31

Edrees FH, Draz ME, Saad AS

280. Integrated analysis of how gender and body weight affect the intestinal microbial diversity of Gymnocypris chilianensis.

Sci Rep

2023 May 31

Zhao Z, Zhao H, Zhang L

281. The metabolic score of insulin resistance is positively correlated with bone mineral density in postmenopausal patients with type 2 diabetes mellitus.

Sci Rep

2023 May 31

Gu P(#), Pu B(#), Xin Q

The prevalence of type 2 diabetes mellitus (T2DM) complicated with osteoporosis (OP) is increasing yearly. Early prevention, detection and treatment of OP are important in postmenopausal patients with T2DM. This study aimed to explore the correlation between insulin resistance and bone mineral density (BMD), and OP in postmenopausal patients with T2DM. In this study, postmenopausal patients with T2DM who visited our hospital from January 2021 to March 2022 were divided into the OP group (n = 91) and non-OP group (n = 119) according to whether they were complicated with OP or not. The general data of patients, BMD, blood routine, glucose metabolism, lipid metabolism, liver and kidney function indexes were collected, and the homeostatic model assessment for IR (HOMA-IR), the triglyceride-glucose (TyG) index and the metabolic score for IR (METS-IR) were calculated. A weighted multivariate linear regression model assessed the correlation between insulin resistance (IR) related indexes and lumbar spine, femoral neck, and hip BMD. A weighted logistic regression model assessed the odds ratios (ORs) and 95% confidence intervals (95% CIs) for the association between the IR-related indexes and OP risk. The nonlinear relationship was also evaluated by smooth curve fitting (SCF) and a weighted generalized additive model (GAM). Moreover, the Receiver-operating characteristics (ROC) curve was used to analyze the predictive efficiency of METS-IR in postmenopausal patients with T2DM with OP. HOMA-IR, TyG, and METS-IR in the OP group were lower than those in the non-OP group (all P < 0.05). Weighted multiple linear regression after adjusting covariates showed that METS-IR was positively correlated with the lumbar spine, femoral neck, and hip BMD (βMETS-IR = 0.006,0.005,0.005, all P < 0.001). The results of weighted Logistic regression and GAM showed that when METS-IR < 44.5, each unit of increased METS-IR value was associated with a decreased OP risk of 12% (P = 0.002). When METS-IR ≥ 44.5, there was no significant correlation between METS-IR and the risk of OP (OR = 1.00, P = 0.934). Similar trends were not observed in HOMA-IR and TyG. The ROC suggested helpful discriminative power of the METS-IR index for T2DM. We confirmed that METS-IR, as a novel alternative marker of IR, had a positive association with BMD in postmenopausal patients with T2DM, and METS-IR was a protective factor for OP in a specific range.

282. Termination of trastuzumab in HER2-positive metastatic breast cancer patients who received trastuzumab beyond progression.

Sci Rep

2023 May 31

Dogan I, Aydin E, Khanmammadov N

283. Molecule generation using transformers and policy gradient reinforcement learning.

Sci Rep

2023 May 31

Mazuz E, Shtar G, Shapira B

284. Taking advantage of noise in quantum reservoir computing.

Sci Rep

2023 May 31

Domingo L, Carlo G, Borondo F.

285. Peripheral immune cell imbalance is associated with cortical beta-amyloid deposition and longitudinal cognitive decline.

Sci Rep

2023 May 31

Mehta NH(#), Zhou L(#), Li Y

Neuroinflammation is believed to be a key process in Alzheimer's disease (AD) pathogenesis. Recently, the neutrophil-to-lymphocyte (NLR) and lymphocyte-to-monocyte ratios (LMR) have been proposed to be useful peripheral markers of inflammation. However, it is unclear how these inflammatory ratios relate to AD pathology, such as β-amyloid (Aβ) plaques and tau tangles. Using 18F-florbetapir and 18F-flortaucipir positron emission tomography (PET), we sought to determine how the NLR and LMR are associated with AD pathology both cross-sectionally and longitudinally. We further evaluated associations between the NLR and LMR and longitudinal cognitive decline. Using data from the Alzheimer's Disease Neuroimaging Initiative, we analyzed blood, PET, and cognitive data from 1544 subjects-405 cognitively normal, 838 with mild cognitive impairment (MCI), and 301 with AD. Associations between the NLR and LMR and Aβ and tau on PET were assessed using ordinary least-squares and mixed-effects regression models, while adjusting for age, sex, years of education, and apolipoprotein E ε2 or ε4 carrier status. Associations between the NLR and LMR and cognitive function, as measured by the AD Assessment Scale-Cognitive Subscale, 13-item version, were also assessed. MCI and AD subjects had higher NLR (p = 0.017, p < 0.001, respectively) and lower LMR (p = 0.013, p = 0.023). The NLR, but not the LMR, was significantly associated with Aβ (p = 0.028), suggesting that higher NLR was associated with greater Aβ deposition in the brain. Neither the NLR nor the LMR was associated with tau deposition (p > 0.05). A higher NLR was associated with greater longitudinal cognitive decline (p < 0.001). A higher ratio of peripheral neutrophils to lymphocytes, possibly reflecting an imbalance in innate versus adaptive immunity, is related to greater Aβ deposition and longitudinal cognitive decline. As the field moves toward blood-based biomarkers of AD, the altered balance of innate versus adaptive immunity could be a useful biomarker of underlying pathology and may also serve as a potential therapeutic target.

286. Automated LVO detection and collateral scoring on CTA using a 3D self-configuring object detection network: a multi-center study.

Sci Rep

2023 May 31

Bagcilar O(#), Alis D(#), Alis C

287. Dietary Ulva lactuca and CAZyme supplementation improve serum biochemical profile and hepatic composition of weaned piglets.

Sci Rep

2023 May 31

Ribeiro DM(#), Lopes PA(#), Pinto RMA

288. Effects of acute psychosocial stress on source level EEG power and functional connectivity measures.

Sci Rep

2023 May 31

Vanhollebeke G, Kappen M, De Raedt R

289. Health consciousness and pro-environmental behaviors in an Italian representative sample: A cross-sectional study.

Sci Rep

2023 May 31

Castellini G, Acampora M, Provenzi L

290. Hypoxia-induced reprogramming of glucose-dependent metabolic pathways maintains the stemness of human bone marrow-derived endothelial progenitor cells.

Sci Rep

2023 May 31

Lin D(#), Yan K(#), Chen L

291. Inferring pseudogene-MiRNA associations based on an ensemble learning framework with similarity kernel fusion.

Sci Rep

2023 May 31

Fan C, Ding M.

292. Effects of three microtubule-associated proteins (MAP2, MAP4, and Tau) on microtubules' physical properties and neurite morphology.

Sci Rep

2023 May 31

Nishida K, Matsumura K, Tamura M

293. Effects of the order of exposure to antimicrobials on the incidence of multidrug-resistant Pseudomonas aeruginosa.

Sci Rep

2023 May 31

Yasuda N(#), Fujita T(#), Fujioka T

294. Predicting body mass index in early childhood using data from the first 1000 days.

Sci Rep

2023 May 31

Cheng ER, Cengiz AY, Miled ZB.

295. Prediction of electrostatic properties of reservoir rock in low salinity water injection into carbonate reservoirs.

Sci Rep

2023 May 31

Parvazdavani M, Khorsand Movaghar MR.

Geochemical modeling along with chemical reactions is one of the challenges in modeling of low salinity water injection. The most important issue in the geochemical model is to determine the correct electrical charge distribution model and its tuning parameters. The composition of the rock as well as the candidate water used is effective in determining the type of model and its parameters, so that the tuning parameters are determined based on the history of zeta potential experiments. In this study, in order to determine the correct model of electrical charge distribution and its tuning parameters in carbonate rock samples, first, equilibrium samples of Candidate water with crushed rock are subjected to static zeta potential tests. Then, the diffuse electrical double layer model is used to determine the electrical charge of the rock/water and water/oil surfaces and to predict the zeta potential. In the following, by adjusting the tuning parameters of the model to match the prediction results of the model with the history of the laboratory data, the density of the carbonate rock surface, the equilibrium constants and the kinetics of the governing reactions are determined. The obtained results show that the range of error in zeta potential prediction by the model compared to the laboratory data is from 2 to 20%, which is within the acceptable range of the performance of electrical charge distribution models. Moreover, it could be observed that the error of prediction using DLM model is significantly less than the conventional models (CD-MUSIC and BSM) for different candidate water. Finally, the effect of calculated zeta potential changes is used to calculate the contact angle changes of low salinity water injection based on the coupling of DLVO theory and geochemical model. The results of the study prove that the prediction error is less than 5% compared to the results of the static wettability tests. Based on this, according to the good match between the model and the laboratory results, it is possible to determine the properties of surface sites in surface complexation models of carbonate samples using the proposed approach and the subsequent tuning data of the geochemical model.

296. The impact of TLR2 and aging on the humoral immune response to Staphylococcus aureus bacteremia in mice.

Sci Rep

2023 May 31

Gupta P, Hu Z, Kopparapu PK

297. Modelling environmental DNA transport in rivers reveals highly resolved spatio-temporal biodiversity patterns.

Sci Rep

2023 May 31

Carraro L, Blackman RC, Altermatt F.

298. 3D mapping of intra-articular calcaneal fractures.

Sci Rep

2023 May 31

Shi G(#), Lin Z(#), Liu W(#)

299. Face masks influence emotion judgments of facial expressions: a drift-diffusion model.

Sci Rep

2023 May 31

Williams WC, Haque E(#), Mai B(#)

300. Improved measurement method for roadbed bearing capacity based on PFWD dynamic modulus control.

Sci Rep

2023 May 31

Li D, Zhang Z, Zhang G.

301. Molecular structure of soluble vimentin tetramers.

Sci Rep

2023 May 31

Vermeire PJ(#), Lilina AV(#), Hashim HM

Intermediate filaments (IFs) are essential constituents of the metazoan cytoskeleton. A vast family of cytoplasmic IF proteins are capable of self-assembly from soluble tetrameric species into typical 10-12 nm wide filaments. The primary structure of these proteins includes the signature central 'rod' domain of ~ 300 residues which forms a dimeric α-helical coiled coil composed of three segments (coil1A, coil1B and coil2) interconnected by non-helical, flexible linkers (L1 and L12). The rod is flanked by flexible terminal head and tail domains. At present, the molecular architecture of mature IFs is only poorly known, limiting our capacity to rationalize the effect of numerous disease-related mutations found in IF proteins. Here we addressed the molecular structure of soluble vimentin tetramers which are formed by two antiparallel, staggered dimers with coil1B domains aligned (A11 tetramers). By examining a series of progressive truncations, we show that the presence of the coil1A domain is essential for the tetramer formation. In addition, we employed a novel chemical cross-linking pipeline including isotope labelling to identify intra- and interdimeric cross-links within the tetramer. We conclude that the tetramer is synergistically stabilized by the interactions of the aligned coil1B domains, the interactions between coil1A and the N-terminal portion of coil2, and the electrostatic attraction between the oppositely charged head and rod domains. Our cross-linking data indicate that, starting with a straight A11 tetramer, flexibility of linkers L1 and L12 enables 'backfolding' of both the coil1A and coil2 domains onto the tetrameric core formed by the coil1B domains. Through additional small-angle X-ray scattering experiments we show that the elongated A11 tetramers dominate in low ionic strength solutions, while there is also a significant structural flexibility especially in the terminal domains.

302. Mitochondrial DNA and local ecological knowledge reveal two lineages of leatherback turtle on the beaches of Oaxaca, Mexico.

Sci Rep

2023 May 31

Castillo-Morales CA, Sáenz-Arroyo A, Castellanos-Morales G

303. A novel beam stopper-based approach for scatter correction in digital planar radiography.

Sci Rep

2023 May 31

Sakaltras N, Pena A, Martinez C

304. Alveolar epithelial cells are competent producers of interstitial extracellular matrix with disease relevant plasticity in a human in vitro 3D model.

Sci Rep

2023 May 31

Rosmark O, Kadefors M, Dellgren G

305. Enhancement of gallium nitride on silicon (111) using pulse atomic-layer epitaxy (PALE) AlN with composition-graded AlGaN buffer.

Sci Rep

2023 May 31

Mansor M, Norhaniza R, Shuhaimi A

306. Fiber counts and architecture of the human dorsal penile nerve.

Sci Rep

2023 May 31

Tunçkol E, Purkart L, Eigen L

307. Aberrant neural processing of event boundaries in persons with Parkinson's disease.

Sci Rep

2023 May 31

Wyrobnik M, van der Meer E, Klostermann F.

308. The influence of hydrothermal fatigue on the clinically relevant functional properties of conventional glass-ionomer cements.

Sci Rep

2023 May 30

Łępicka M, Niewczas AM, Rodziewicz MU

309. Altered functional connectivity of the ascending reticular activating system in obstructive sleep apnea.

Sci Rep

2023 May 30

Byun JI, Jahng GH, Ryu CW

310. Optical-referenceless optical frequency counter with twelve-digit absolute accuracy.

Sci Rep

2023 May 30

Ishizawa A, Nishikawa T, Hitachi K

311. An interaction and feedback mechanism-based group decision-making for emergency medical supplies supplier selection using T-spherical fuzzy information.

Sci Rep

2023 May 30

Gurmani SH, Zhang Z, Zulqarnain RM

312. Plant viruses induce plant volatiles that are detected by aphid parasitoids.

Sci Rep

2023 May 30

Milonas PG, Anastasaki E, Psoma A

313. Three-month outcomes of faricimab loading therapy for wet age-related macular degeneration in Japan.

Sci Rep

2023 May 30

Mukai R, Kataoka K, Tanaka K

314. Privacy and the acceptance of centralized digital currencies in the U.S., India and Germany.

Sci Rep

2023 May 30

Mehlkop G, Neumann R, von Hermanni H.

315. Anatomical damage caused by Bacillus thuringiensis variety israelensis in yellow fever mosquito Aedes aegypti (L.) larvae revealed by micro-computed tomography.

Sci Rep

2023 May 30

Alba-Tercedor J, Vilchez S.

316. Investigation of variables affecting the immunogenicity of blood group antigens using a calculation formula.

Sci Rep

2023 May 30

Chung Y, Kim HJ, Kim H

317. Cracks propagation characteristics of double-hole delay blasting in soft-hard composite rock mass.

Sci Rep

2023 May 30

Cui J, Xie L, Qin Y

318. Deep learning model accurately classifies metastatic tumors from primary tumors based on mutational signatures.

Sci Rep

2023 May 30

Zheng W(#), Pu M(#), Li X

319. Surveillance of prognostic risk factors in patients with SCCB using artificial intelligence: a retrospective study.

Sci Rep

2023 May 30

Zhanghuang C(#), Zhang Z(#), Wang J

Small cell carcinoma of the bladder (SCCB) is a rare urological tumor. The prognosis of SCCB is abysmal. Therefore, this study aimed to construct nomograms that predict overall survival (OS) and cancer-specific survival (CSS) in SCCB patients. Information on patients diagnosed with SCCB during 2004-2018 was obtained from the Surveillance, Epidemiology, and End Results (SEER) database. Univariate and multivariate Cox regression models analyzed Independent risk factors affecting patients' OS and CSS. Nomograms predicting the OS and CSS were constructed based on the multivariate Cox regression model results. The calibration curve verified the accuracy and reliability of the nomograms, the concordance index (C-index), and the area under the curve (AUC). Decision curve analysis (DCA) assessed the potential clinical value. 975 patients were included in the training set (N = 687) and the validation set (N = 288). Multivariate COX regression models showed that age, marital status, AJCC stage, T stage, M stage, surgical approach, chemotherapy, tumor size, and lung metastasis were independent risk factors affecting the patients' OS. However, distant lymph node metastasis instead AJCC stage is the independent risk factor affecting the CSS in the patients. We successfully constructed nomograms that predict the OS and CSS for SCCB patients. The C index of the training set and the validation set of the OS were 0.747 (95% CI 0.725-0.769) and 0.765 (95% CI 0.736-0.794), respectively. The C index of the CSS were 0.749 (95% CI 0.710-0.773) and 0.786 (95% CI 0.755-0.817), respectively, indicating that the predictive models of the nomograms have excellent discriminative power. The calibration curve and the AUC also show good accuracy and discrimination of the nomograms. To sum up, We established nomograms to predict the OS and CSS of SCCB patients. The nomograms have undergone internal cross-validation and show good accuracy and reliability. The DCA shows that the nomograms have an excellent clinical value that can help doctors make clinical-assisted decision-making.

320. A 5-emotions stimuli set for emotion perception research with full-body dance movements.

Sci Rep

2023 May 30

Christensen JF, Bruhn L, Schmidt EM

321. Impact of repeated morning bright white light exposures on attention in a simulated office environment.

Sci Rep

2023 May 30

Canazei M, Dick M, Pohl W

322. Forecasting COVID-19 activity in Australia to support pandemic response: May to October 2020.

Sci Rep

2023 May 30

Moss R, Price DJ, Golding N

323. Failure analysis and prediction of roof instability in end face under repeated mining using early warning system.

Sci Rep

2023 May 30

Li F, Kong D(#), Li Q

324. Microfibril-associated protein 5 and the regulation of skin scar formation.

Sci Rep

2023 May 30

Han C, Leonardo TR, Romana-Souza B

325. Thoracolaparoscopic radical esophagectomy for esophageal cancer based on the mesoesophageal theory.

Sci Rep

2023 May 30

Sun YX, Zhu TY, Wang GJ

To explore the feasibility of mesangium or membrane anatomy theory in thoracolaparoscopic radical esophagectomy for esophageal cancer, 98 patients with esophageal cancer were enrolled including 45 patients in the mesoesophageal esophagectomy group and 53 patients in the non-mesoesophageal esophagectomy group. Thoracolaparoscopic radical esophagecotmy was technically successful in all patients. Compared the non-mesoesophageal group, the mesoesophageal group had significantly (P < 0.05) shorter surgical duration (211.9 ± 42.0 min vs. 282.0 ± 44.5 min), less blood loss during the procedure (68.9 ± 45.9 ml vs. 167.0 ± 91.4 ml), more harvested lymph nodes (25.9 ± 6.3 vs. 21.8 ± 7.3), shorter hospital stay after surgery (10.5 ± 2.5 d vs. 12.5 ± 4.2 d), shorter fasting time or quicker postoperative feeding time (7.3 ± 1.2 d vs. 9.5 ± 3.9 d), and quicker removal of the thoracic drainage tube after surgery (7.7 ± 2.0 d vs. 9.2 ± 4.1 d). The overall incidence of postoperative complications was 46.7% (21/45) in the mesoesophageal group, which was significantly (P = 0.02) fewer than that (69.8% or 37/53) of the non-mesoesophageal group (P = 0.020). During follow-up 20.6 ± 4.3 or 20.8 ± 3.4 months after esophagectomy, liver metastasis occurred in 1 case and lung metastasis in 1 in the mesoesophageal group, whereas liver metastasis occurred in 2 cases, mediastinal metastasis in 2, and anastomotic recurrence in 1 in the non-mesoesophageal group. The mesoesophageal group had significantly better physical function (81.9 ± 7.3 vs. 78.3 ± 7.6), social function (65.1 ± 7.1 vs. 56.2 ± 18.2), global health status (65.3 ± 10.1 vs. 58.7 ± 12.4), and pain improvement (29.5 ± 9.5 vs. 35.6 ± 10.6). The overall survival rate was 82.2% (37/45) in the mesoesophageal group and 71.7% (38/53) in the non-mesoesophageal group (P = 0.26). The disease-free survival rate was 77.8% (35/45) for the mesoesophageal group and 62.3% (33/53) for the non-mesoesophageal group (P = 0.13). In conclusion:, the mesangium or membrane anatomy theory can be used safely and effectively to guide thoracolaparoscopic radical esophagectomy for esophageal cancer, with advantages of shorter surgical time, less bleeding, more lymph node harvest, fewer complications, and faster postoperative recovery.

326. Hopf physical reservoir computer for reconfigurable sound recognition.

Sci Rep

2023 May 30

Shougat MREU(#), Li X(#), Shao S(#)

327. Trophic ecology of Octopus vulgaris paralarvae along the Iberian Canary current eastern boundary upwelling system.

Sci Rep

2023 May 30

Roura Á, Doyle SR, Castro-Bugallo A

Our knowledge of the diet of wild octopus paralarvae, Octopus vulgaris, is restricted to the first 2 weeks of its planktonic phase when they are selective hunters found near the coastline. These small paralarvae, bearing only three suckers per arm, are transported by oceanic currents from the coast towards offshore waters, where they complete the planktonic phase over 2 months. Here, we have investigated the trophic ecology of O. vulgaris paralarvae in two contrasting upwelling sub-regions of the Iberian Canary current (ICC) eastern boundary upwelling system and have evaluated dietary change as paralarvae develop (inferred by counting the number of suckers per arm, ranging from three to 15) along the coastal-oceanic gradient during their planktonic phase. Using high-throughput amplicon sequencing, we have characterised the diet of 100 paralarvae collected along the Northwest Iberian Peninsula (n = 65, three to five suckers per arm) and off the west coast of Morocco (n = 35, three to 15 suckers per arm), identifying up to 87 different prey species. The diet of paralarvae varied along the ICC, with crabs (53.4%), siphonophores (12.2%), copepods (12.3%), cnidarians (8.4%) and pteropods (3.7%) accounting for 90% of the variability detected off NW Iberian Peninsula, whereas off W Morocco, crabs (46.2%), copepods (23.1%), cnidarians (12.9%), krill (9.3%) and fishes (4.2%) explained 95.6% of the variability observed using frequency of observance (FOO%) data. Ontogenetic changes in the diet based on groups of paralarvae with similar numbers per arm were evidenced by the decreasing contribution of coastal meroplankton and an increase in oceanic holoplankton, including siphonophores, copepods, pteropods and krill. Trophic niche breadth values ranged from 0.06 to 0.67, with averaged values ranging from 0.23 to 0.33 (generalist = 1 and specialist = 0), suggesting that O. vulgaris paralarvae are selective predators through their ontogenetic transition between coastal and oceanic environments.

328. B cell-specific knockout of AID protects against atherosclerosis.

Sci Rep

2023 May 30

Ebrahimian T(#), Dierick F(#), Ta V

329. Severe SARS-CoV-2 infection as a marker of undiagnosed cancer: a population-based study.

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2023 May 30

Dugerdil A(#), Semenzato L(#), Weill A

330. The international role of education in sustainable lifestyles and economic development.

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2023 May 30

Piao X, Managi S.

331. Community-based diabetes prevention randomized controlled trial in refugees with depression: effects on metabolic outcomes and depression.

Sci Rep

2023 May 30

Wagner JA, Bermúdez-Millán A, Buckley TE

332. Cardiovascular characterisation of a novel mouse model that combines hypertension and diabetes co-morbidities.

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2023 May 30

Sharma A, Choi JSY, Watson AMD

Epidemiologic data suggest that the prevalence of hypertension in patients with diabetes mellitus is ∼1.5-2.0 times greater than in matched non-diabetic patients. This co-existent disease burden exacerbates cardiac and vascular injury, leading to structural and functional changes to the myocardium, impaired cardiac function and heart failure. Oxidative stress and persistent low-grade inflammation underlie both conditions, and are identified as major contributors to pathological cardiac remodelling. There is an urgent need for effective therapies that specifically target oxidative stress and inflammation to protect against cardiac remodelling. Animal models are a valuable tool for testing emerging therapeutics, however, there is a notable lack of appropriate animal models of co-morbid diabetes and hypertension. In this study, we describe a novel preclinical mouse model combining diabetes and hypertension to investigate cardiac and vascular pathology of co-morbid disease. Type 1 diabetes was induced in spontaneously hypertensive, 8-week old, male Schlager (BPH/2) mice via 5 consecutive, daily injections of streptozotocin (55 mg/kg in citrate buffer; i.p.). Non-diabetic mice received citrate buffer only. After 10 weeks of diabetes induction, cardiac function was assessed by echocardiography prior to post-mortem evaluation of cardiomyocyte hypertrophy, interstitial fibrosis and inflammation by histology, RT-PCR and flow cytometry. We focussed on the oxidative and inflammatory stress pathways that contribute to cardiovascular remodelling. In particular, we demonstrate that markers of inflammation (monocyte chemoattractant protein; MCP-1), oxidative stress (urinary 8-isoprostanes) and fibrosis (connective tissue growth factor; CTGF) are significantly increased, whilst diastolic dysfunction, as indicated by prolonged isovolumic relaxation time (IVRT), is elevated in this diabetic and hypertensive mouse model. In summary, this pre-clinical mouse model provides researchers with a tool to test therapeutic strategies unique to co-morbid diabetes and hypertension, thereby facilitating the emergence of novel therapeutics to combat the cardiovascular consequences of these debilitating co-morbidities.

333. The epidemiology of upper respiratory tract disorders in a population of insured Swedish dogs (2011-2014), and its association to brachycephaly.

Sci Rep

2023 May 30

Dimopoulou M, Engdahl K, Ladlow J

334. Diagnosis of sudden cardiac arrest using principal component analysis in automated external defibrillators.

Sci Rep

2023 May 30

Pham VS, Nguyen A, Dang HB

335. Surface protein profiling of milk and serum extracellular vesicles unveils body fluid-specific signatures.

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2023 May 30

Giovanazzi A, van Herwijnen MJC, Kleinjan M

336. Effects of schema on the relationship between post-encoding brain connectivity and subsequent durable memory.

Sci Rep

2023 May 30

Guo D, Chen G, Yang J.

337. PSO tuned interval type-2 fuzzy logic for load frequency control of two-area multi-source interconnected power system.

Sci Rep

2023 May 30

Soliman AMA, Bahaa M, Mehanna MA.

338. Comparative genomic analysis uncovers candidate genes related with milk production and adaptive traits in goat breeds.

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2023 May 30

Amiri Ghanatsaman Z, Ayatolahi Mehrgardi A, Asadollahpour Nanaei H

339. Characterization of lab-based swarms of Anopheles gambiae mosquitoes using 3D-video tracking.

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2023 May 30

Cavagna A, Giardina I, Gucciardino MA

340. Identification and localization of polar tube proteins in the extruded polar tube of the microsporidian Anncaliia algerae.

Sci Rep

2023 May 30

Fayet M, Prybylski N, Collin ML

341. Heat and mass transfer analysis for magnetized flow of [Formula: see text] nanolubricant with variable properties: an application of Cattaneo-Christov model.

Sci Rep

2023 May 30

Riaz M, Khan N, Hashmi MS

The current study scrutinizes heat and mass transfer features of magnetized flow of [Formula: see text] nanolubricant over Riga plate in a Darcy Forchheimer medium. The effects of variable viscosity, thermal radiation, variable thermal conductivity, viscous dissipation and uniform heat source/sink are examined in this study. The diffusion model presented by Cattaneo-Christov is incorporated in this study to enclose heat and mass transport phenomenon. Additionally, the mass transfer rate is inspected subjected to the effects of variable solutal diffusivity and higher order chemical reaction. Heat and mass transfer phenomena have significant applications in the disciplines of science and technology that can be seen everywhere in nature. This simultaneous transportation phenomenon indicates a variety of applications in manufacturing processes, aerodynamics, cooling systems, environmental sciences, oceanography, food industries, biological disciplines, and energy transport systems etc. The modeled system of PDEs is metamorphosed to nonlinear ODEs with the introduction of appropriate transformations. An eminent bvp4c method in MATLAB has been incorporated to execute the resulting system of ODEs numerically. The outcomes of velocity, temperature and concentration profiles corresponding to various emerging parameters have been exposed graphically. The motion of [Formula: see text] nanolubricant tends to enhance significantly with larger modified Hartmann number, whereas converse behavior is reported by increasing porosity parameter and variable viscosity parameter. The greater heat transfer rate is observed for variable thermal conductivity parameter. The rates of heat and mass transfer slow down for thermal and solutal time relaxation parameters respectively. The concentration profile gets enriched by growing the order of the chemical reaction and variable mass diffusivity parameter. It is concluded that by increasing solid volume fraction up to [Formula: see text], the viscosity of the nanolubricant enhances up to [Formula: see text] which consequently slows down motion of the nanolubricant but increases temperature and concentration profiles.

342. Experimental study on damage characteristics of Beishan granite under single loading and multiple loading with AE techniques.

Sci Rep

2023 May 30

Wang Z, Zhou G, Ge X.

343. Molecular identification of Phlebotomus kandelakii apyrase and assessment of the immunogenicity of its recombinant protein in BALB/c mice.

Sci Rep

2023 May 30

Fayaz S, Raz A, Bahrami F

344. Inferring the ecology of north-Pacific albacore tuna from catch-and-effort data.

Sci Rep

2023 May 30

Ijima H, Minte-Vera C, Chang YJ

345. Breast cancer prevention with liquiritigenin from licorice through the inhibition of aromatase and protein biosynthesis in high-risk women's breast tissue.

Sci Rep

2023 May 30

Hajirahimkhan A, Howell C, Bartom ET

346. Correlating the differences in the receptor binding domain of SARS-CoV-2 spike variants on their interactions with human ACE2 receptor.

Sci Rep

2023 May 30

Mahalingam G, Arjunan P, Periyasami Y

347. Mathematical model analysis of effective intervention strategies on transmission dynamics of hepatitis B virus.

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2023 May 30

Wodajo FA, Gebru DM, Alemneh HT.

348. Childhood maltreatment and emotion regulation in everyday life: an experience sampling study.

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2023 May 3

Ion A, Bîlc MI, Pițur S

349. Underscoring the effect of swab type, workflow, and positive sample order on swab pooling for COVID-19 surveillance testing.

Sci Rep

2023 May 3

Kalinowski MJ(#), Hartigan DR(#), Lojek NM

Sample pooling is a promising strategy to facilitate COVID-19 surveillance testing for a larger population in comparison to individual single testing due to resource and time constraints. Increased surveillance testing capacity will reduce the likelihood of outbreaks as the general population is returning to work, school, and other gatherings. We have analyzed the impact of three variables on the effectiveness of pooling test samples: swab type, workflow, and positive sample order. We investigated the performance of several commercially available swabs (Steripack polyester flocked, Puritan nylon flocked, Puritan foam) in comparison to a new injected molded design (Yukon). The bench-top performance of collection swab was conducted with a previously developed anterior nasal cavity tissue model, based on a silk-glycerol sponge to mimic soft tissue mechanics and saturated with a physiologically relevant synthetic nasal fluid spiked with heat-inactivated SARS-CoV-2. Overall, we demonstrated statistically significant differences in performance across the different swab types. A characterization of individual swab uptake (gravimetric analysis) and FITC microparticle release suggests that differences in absorbance and retention drive the observed differences in Ct of the pooled samples. We also proposed two distinct pooling workflows to encompass different community collection modes and analyzed the difference in resulting positive pools as an effect of workflow, swab type, and positive sample order. Overall, swab types with lower volume retention resulted in reduced false negative occurrence, also observed for collection workflows with limited incubation times. Concurrently, positive sample order did have a significant impact on pooling test outcome, particularly in the case of swab type with great volume retention. We demonstrated that the variables investigated here affect the results of pooled COVID-19 testing, and therefore should be considered while designing pooled surveillance testing.

350. Trends in mortality outcomes of hospital-admitted injury in Victoria, Australia 2001-2021.

Sci Rep

2023 May 3

Berecki-Gisolf J, Fernando T, D'Elia A.

Due to advancements in trauma treatment methods, it is expected that survivability of hospital-admitted injuries gradually improves over time. However, measurement of trends in all-cause injury survivability is complicated by changes in case mix, demographics and hospital admission policy. The aim of this study is to determine trends in hospital-admitted injury survivability in Victoria, Australia, taking case-mix and patient demographics into account, and to explore the potential impact of changes in hospital admission practices. Injury admission records (ICD-10-AM codes S00-T75 and T79) between 1 July 2001 and 30 June 2021 were extracted from the Victorian Admitted Episodes Dataset. ICD-based Injury Severity Score (ICISS) calculated from Survival Risk Ratios for Victoria was used as an injury severity measure. Death-in-hospital was modelled as a function of financial year, adjusting for age group, sex and ICISS, as well as admission type and length of stay. There were 19,064 in-hospital deaths recorded in 2,362,991 injury-related hospital admissions in 2001/02-2020/21. Rates of in-hospital death decreased from 1.00% (866/86,998) in 2001/02 to 0.72% (1115/154,009) in 2020/21. ICISS was a good predictor of in-hospital death with an area-under-the-curve of 0.91. In-hospital death was associated with financial year (Odds Ratio 0.950 [95%CI 0.947, 0.952]), in logistic regression modelling adjusted for ICISS, age and sex. In stratified modelling, decreasing injury death trends were observed in each of the top 10 injury diagnoses (together constituting > 50% of cases). Admission type and length of stay were added to the model: these did not alter the effect of year on in-hospital death. In conclusion, a 28% reduction in rates of in-hospital deaths in Victoria was observed over the 20-year study period, in spite of aging of the injured population. This amounts to 1222 additional lives saved in 2020/21 alone. Survival Risk Ratios therefore change markedly over time. A better understanding of the drivers of positive change will help to further reduce the injury burden in Victoria.

351. Using augmented reality to guide bone conduction device implantation.

Sci Rep

2023 May 3

Lui JT, Dahm V, Chen JM

352. Human and dog Bayesian dietary mixing models using bone collagen stable isotope ratios from ancestral Iroquoian sites in southern Ontario.

Sci Rep

2023 May 3

Hart JP.

353. Real world evidence of adjuvant trastuzumab in HER2 positive early breast cancer.

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2023 May 3

Lluch-Gómez J, Núñez-Álvarez V, de la Torre-Hita C

Adjuvant trastuzumab in HER2+ breast cancer reduces recurrence and mortality, and has been the standard treatment since 2006. The objective was to analyze health outcomes in the real world. Observational, retrospective study of patients with HER2+ breast cancer, stages I-III, treated with adjuvant trastuzumab in the past 15 years in only one center and for the first time in Spain. Survival was analyzed according to the number of cycles and cardiotoxicity. Two hundred and seventy-five HER2positive patients (18.60%) out of 1479 received adjuvant (73%) or neoadjuvant/adjuvant (26%) trastuzumab, concomitantly (90%) or sequentially (10%) with chemotherapy. The probability of overall and disease-free survival (OS and DFS) at 5 years was 0.93 (95% CI 0.89-0.96), and 0.88 (95% CI 0.83-0.92). The number of cases with a significant and asymptomatic decrease in ventricular ejection fraction and heart failure were 54 (19.64%) and 12 (4.36%), respectively. Sixty-eight patients (24.70%) received 16 or fewer cycles, especially those older than 65 (OR 0.371, 95% CI 0.152-0.903; p = 0.029) and with cardiotoxicity (OR 15.02, 95% CI 7.437-30.335; p < 0.001). The risk of cardiotoxicity was associated with having received radiotherapy (OR 0.0362, 95% CI 0.139-0.938; p = 0.037). Arterial hypertension (HR 0.361, 95% CI 0.151-0.863, p = 0.022), neoadjuvant treatment (HR 0.314, 95% CI 0.132-0.750, p = 0.009) and cardiotoxicity (HR 2.755, 95% CI 1.235-6.143, p = 0.013) maintained significant association with OS. Only neoadjuvant treatment maintained a significant association with DFS (HR 0.437, 95% CI 0.213-0.899, p = 0.024). The effectiveness of neoadjuvant and adjuvant trastuzumab can be considered comparable to those of clinical trials. In the real world, factors such as age, hypertension, radiotherapy, neoadjuvant treatment, and cardiotoxicity should be taken into consideration to optimize outcomes.

354. Factors associated with Diabetes Empowerment among patients with type 2 diabetes, at OPD setting, Karachi, Pakistan.

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2023 May 3

Khowaja MA, Rozi S, Sawani S

355. Framework of magnetostrain responsive Ni-Mn-Ga microparticles driving magnetic field induced out-of-plane actuation of laminate composite.

Sci Rep

2023 May 3

Han D, Chiu WT, Tahara M

356. A 6-year nationwide population-based study on the current status of gastric endoscopic resection in Korea using administrative data.

Sci Rep

2023 May 3

Park JY, Kim MS, Kim BJ

357. Vegetarians have an indirect positive effect on sleep quality through depression condition.

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2023 May 3

Wang X, Song F, Wang B

358. Ce:LYSO, from scintillator to solid-state lighting as a blue luminescent concentrator.

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2023 May 3

Lopez L, Pichon P, Loiseau P

359. Neurophysiological markers of emotion regulation predict efficacy of entrepreneurship education.

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2023 May 3

Egana-delSol P, Sun X, Sajda P.

360. Exploring the mechanism underlying hyperuricemia using comprehensive research on multi-omics.

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2023 May 3

Liu H(#), Xie R(#), Dai Q

361. Mortality and bleeding associated with the management of sub-massive pulmonary embolism: a systematic review and Bayesian network meta-analysis.

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2023 May 3

Mathew D, Kim J, Kosuru BP

362. Multi-scale semantic enhancement network for object detection.

Sci Rep

2023 May 3

Guo D, Wu Z, Feng J

363. Machine learning reduces soft costs for residential solar photovoltaics.

Sci Rep

2023 May 3

Dong C, Nemet G, Gao X

364. External beam radiotherapy inhibits stent related granulation hyperplasia in rabbit trachea.

Sci Rep

2023 May 3

Zhou Z(#), Han B(#), Ren K

365. Selective pertraction of dicarboxylic acids from simulated Rhizopus oryzae fermentation broths.

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2023 May 3

Kloetzer L, Blaga AC, Caşcaval D

366. Reduction of rupture risk in ICA aneurysms by endovascular techniques of coiling and stent: numerical study.

Sci Rep

2023 May 3

Rostamian A, Fallah K, Rostamiyan Y.

367. Acoustic stability of a self-gravitating cylinder leading to astrostructure formation.

Sci Rep

2023 May 3

Dasgupta S, Atteya A, Karmakar PK.

368. Lymphocyte-C-reactive protein ratio with calf circumference could better predict survival of patients with non-metastatic cancer.

Sci Rep

2023 May 3

Liu XY, Zhang X, Zhang Q

Systemic inflammatory responses caused by tumor cells play an important role in the occurrence and development of tumors. The aim of this study was to identify biomarkers that most accurately predict prognoses in patients with non-metastatic cancer and to evaluate their clinical significance when combined with muscle markers. This study retrospectively evaluated 2,797 cancer patients diagnosed with cancer at TNM stages I, II, and III. Lymphocyte-C-reactive protein ratio (LCR) in conjunction with calf circumference (CC) were used (or chosed) after evaluating the predictive value of 13 inflammatory marker combinations and five anthropometric indicators for patient outcomes using the C-index. The Kaplan-Meier method and Cox's proportional hazards regression modeling were used to analyze the individual and combined effects of these two potential biomarkers on overall survival. This study enrolled 1,604 men (57.3%) and 1,193 women (42.7%) with a mean age of 58.75 years. Among the 13 inflammatory nutritional indicators, the LCR was the most accurate predictor of prognoses in patients with non-metastatic cancer. After multifactorial adjustment, we found that low LCR had an adverse effect on overall survival (hazard ratio [HR]: 2.50; 95% confidence interval [CI]: 2.17, 2.88; P < 0.001). Low LCR combined with low CC was also shown to be an independent risk factor for poor overall survival (HR: 2.26; 95% CI: 1.80, 2.83; P < 0.001). Compared with LCR or CC alone, the combination of the two had greater prognostic value for patients with non-metastatic cancer. The LCR can be implemented as a useful biomarker to predict prognoses in patients with non-metastatic cancer. CC is the best anthropometric indicator of muscle loss in patients with non-metastatic cancer. The combination of LCR and CC can better predict the prognosis of patients with non-metastatic cancer, and can provide important information for clinicians to formulate diagnosis and treatment plans.

369. Effects of total daily light integral from blue and broad-band red LEDs on flowering of saffron (Crocus sativus L.).

Sci Rep

2023 May 3

Gao D, Ji X, Yuan Q

370. The association between food desert severity, socioeconomic status, and metabolic state during pregnancy in a prospective longitudinal cohort.

Sci Rep

2023 May 3

Wood EK, Stamos G, Mitchell AJ

Poor metabolic health during pregnancy is associated with health concerns for pregnant individuals and their offspring. Lower socioeconomic status (SES) is one risk factor for poor metabolic health, and may be related to limited access to healthful and affordable foods (e.g., living in a food desert). This study evaluates the respective contributions of SES and food desert severity on metabolic health during pregnancy. The food desert severity of 302 pregnant individuals was determined using the United States Department of Agriculture Food Access Research Atlas. SES was measured using total household income adjusted for household size, years of education, and amount of reserve savings. Information about participants' glucose concentrations one hour following an oral glucose tolerance test during the second trimester was extracted from medical records and percent adiposity during the second trimester was assessed using air displacement plethysmography. Information about participants' nutritional intake during the second trimester was obtained by trained nutritionists via three unannounced 24-h dietary recalls. Structural equation models showed that lower SES predicted higher food desert severity (β = - 0.20, p = 0.008) and higher adiposity (β = - 0.27, p = 0.016) and consumption of a more pro-inflammatory diet (β = - 0.25, p = 0.003) during the second trimester of pregnancy. Higher food desert severity also predicted higher percent adiposity during the second trimester (β = 0.17, p = 0.013). Food desert severity significantly mediated the relationship between lower SES and higher percent adiposity during the second trimester (βindirect = - 0.03, 95% CI [- 0.079, - 0.004]). These findings indicate that access to healthful and affordable foods is a mechanism by which SES contributes to adiposity during pregnancy and may inform interventions intended to improve metabolic health during pregnancy.

371. Management and outcome trends in type 2 myocardial infarction: an investigation from the SWEDEHEART registry.

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2023 May 3

Eggers KM, Baron T, Chapman AR

372. Psychometric properties of the Bern illegitimate tasks scale using classical test and item response theories.

Sci Rep

2023 May 3

Basinska BA, Dåderman AM.

373. Machine learning based on computational fluid dynamics enables geometric design optimisation of the NeoVAD blades.

Sci Rep

2023 May 3

Nissim L, Karnik S, Smith PA

374. Numerical solution of an electrically conducting spinning flow of hybrid nanofluid comprised of silver and gold nanoparticles across two parallel surfaces.

Sci Rep

2023 May 3

Alqahtani AM, Bilal M, Ali A

375. A neural network based global traveltime function (GlobeNN).

Sci Rep

2023 May 3

Taufik MH, Waheed UB, Alkhalifah TA.

376. Heart disease risk factors detection from electronic health records using advanced NLP and deep learning techniques.

Sci Rep

2023 May 3

Houssein EH, Mohamed RE, Ali AA.

377. Feasibility of in vivo swine models using guide wire-assisted intraductal radiofrequency ablation for benign biliary stricture.

Sci Rep

2023 May 3

Park JK, Yang JI, Park JK

378. Impact of anti-thymocyte globulin on survival outcomes in female-to-male allogeneic hematopoietic stem cell transplantation.

Sci Rep

2023 May 3

Tamaki M, Akahoshi Y, Ashizawa M

379. Using network analysis to explore the validity and influential items of the Parkinson's Disease Questionnaire-39.

Sci Rep

2023 May 3

Schönenberg A, Santos García D, Mir P

380. Retinal image enhancement based on color dominance of image.

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2023 May 3

C P(#), R JK(#).

381. Investigation of composition, antioxidant, antimicrobial and cytotoxic characteristics from Juniperus sabina and Ferula communis extracts.

Sci Rep

2023 May 3

Kavaz D, Faraj RE.

382. Correlation between bilateral lateral rectus muscle recession and myopic progression in children with intermittent exotropia.

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2023 May 3

Han JY, Han J, Han SH.

383. Predictive value of acoustic cardiography for post-PCI early ventricular remodeling in acute myocardial infarction.

Sci Rep

2023 May 3

Wang W(#), Hao H(#), Fan T

384. Seroprevalence of rubella virus infection among antenatal care clients of Halaba Town public health facilities, southern Ethiopia.

Sci Rep

2023 May 3

Asrat B, Shimelis T, Assefa AA

385. Eyestalk transcriptome and methyl farnesoate titers provide insight into the physiological changes in the male snow crab, Chionoecetes opilio, after its terminal molt.

Sci Rep

2023 May 3

Toyota K(#), Yamamoto T(#), Mori T

386. Blink rate and facial orientation reveal distinctive patterns of attentional engagement in autistic toddlers: a digital phenotyping approach.

Sci Rep

2023 May 3

Krishnappa Babu PR(#), Aikat V(#), Di Martino JM

387. Effect of target thickness and laser irradiance on the back-reflection-enhanced laser-induced breakdown spectroscopy signal in glass.

Sci Rep

2023 May 3

Elhassan A, Abdel-Harith M, Abdelhamid M.

388. En-face optical coherence tomography hyperreflective foci of choriocapillaris in central serous chorioretinopathy.

Sci Rep

2023 May 3

Hwang BE, Kim JY, Kim RY

389. Bone mineral density and microarchitecture change during skeletal growth in harbor seals (Phoca vitulina) from the German coast.

Sci Rep

2023 May 3

Delsmann J(#), Schmidt B(#), Oheim R

Across species, the skeletal system shares mutual functions, including the protection of inner organs, structural basis for locomotion, and acting as an endocrine organ, thus being of pivotal importance for survival. However, insights into skeletal characteristics of marine mammals are limited, especially in the growing skeleton. Harbor seals (Phoca vitulina) are common marine mammals in the North and Baltic Seas and are suitable indicators of the condition of their ecosystem. Here, we analyzed whole-body areal bone mineral density (aBMD) by dual-energy X-ray absorptiometry (DXA) and lumbar vertebrae by high-resolution peripheral quantitative computed tomography (HR-pQCT) in neonate, juvenile, and adult harbor seals. Along skeletal growth, an increase in two-dimensional aBMD by DXA was paralleled by three-dimensional volumetric BMD by HR-pQCT, which could be attributed to an increasing trabecular thickness while trabecular number remained constant. Strong associations were observed between body dimensions (weight and length) and aBMD and trabecular microarchitecture (R2 = 0.71-0.92, all p < 0.001). To validate the results of the DXA measurement (i.e., the standard method used worldwide to diagnose osteoporosis in humans), we performed linear regression analyses with the three-dimensional measurements from the HR-pQCT method, which revealed strong associations between the two imaging techniques (e.g., aBMD and Tb.Th: R2 = 0.96, p < 0.0001). Taken together, our findings highlight the importance of systematic skeletal investigations in marine mammals during growth, illustrating the high accuracy of DXA in this context. Regardless of the limited sample size, the observed trabecular thickening is likely to represent a distinct pattern of vertebral bone maturation. As differences in nutritional status, among other factors, are likely to affect skeletal health, it appears essential to routinely perform skeletal assessments in marine mammals. Placing the results in the context of environmental exposures may allow effective measures to protect their populations.

390. The temporal precision of audiovisual integration is associated with longitudinal fall incidents but not sensorimotor fall risk in older adults.

Sci Rep

2023 May 3

O'Dowd A, Hirst RJ, Setti A

391. Three genes expressed in relation to lipid metabolism considered as potential biomarkers for the diagnosis and treatment of diabetic peripheral neuropathy.

Sci Rep

2023 May 29

Yang Y, Wang Q.

392. Quantification of patellar tendon strain and opportunities for personalized tendon loading during back squats.

Sci Rep

2023 May 29

Weidlich K, Mersmann F, Domroes T

393. An artificial neural network-based radiomics model for predicting the radiotherapy response of advanced esophageal squamous cell carcinoma patients: a multicenter study.

Sci Rep

2023 May 29

Xie Y, Liu Q, Ji C

394. Mixed Micromax and hematite-based fly ash geopolymer for heavy-weight well cementing.

Sci Rep

2023 May 29

Abdelaal A, Elkatatny S.

395. The potential role of the pseudobranch of molly fish (Poecilia sphenops) in immunity and cell regeneration.

Sci Rep

2023 May 29

Mokhtar DM, Sayed RKA, Zaccone G

396. A specific dispiropiperazine derivative that arrests cell cycle, induces apoptosis, necrosis and DNA damage.

Sci Rep

2023 May 29

Liu VP, Li WM, Lofroth J

397. Adversity specificity and life period exposure on cognitive aging.

Sci Rep

2023 May 29

Künzi M, Sieber S, Joly-Burra E

398. Electromagnetic field-enhanced novel tubular electrocoagulation cell for effective and low-cost color removal of beet sugar industry wastewater.

Sci Rep

2023 May 29

Fadali OA, Ali RH, Nassar MM

399. Mechanisms of mechanical load transfer through brain tissue.

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2023 May 29

Reiter N, Paulsen F, Budday S.

400. Identification of ferroptosis and drug resistance related hub genes to predict the prognosis in Hepatocellular Carcinoma.

Sci Rep

2023 May 29

Li C, Cui X, Li Y

Hepatocellular carcinoma (HCC) is the third leading cause of cancer-related death worldwide. Currently, overcoming the drug resistance in HCC is a critical challenge and ferroptosis has emerged as a promising therapeutic option for cancer. We aim to construct a new gene signature related to ferroptosis and drug resistance to predict the prognosis in HCC. The RNA-seq data of HCC patients was obtained from the Cancer Genome Atlas database. Using least absolute shrinkage and selection operator cox regression, Kaplan-Meier analysis, and differential analysis, we constructed a prognostic model consisting of six hub genes (TOP2A, BIRC5, VEGFA, HIF1A, FTH1, ACSL3) related to ferroptosis and drug resistance in HCC. Functional enrichment, pathway enrichment and GSEA analysis were performed to investigate the potential molecular mechanism, and construction of PPI, mRNA-miRNA, mRNA-RBP, mRNA-TF and mRNA-drugs interaction networks to predict its interaction with different molecules. Clinical prognostic characteristics were revealed by univariate, multivariate cox regression analysis and nomogram. We also analyzed the relationship between the signature, immune checkpoints, and drug sensitivity. The expression of the gene signature was detected in HCC cell lines and HPA database. Our prognostic model classified patients into high and low-risk groups based on the risk scores and found the expression level of the genes was higher in the high-risk group than the low-risk group, demonstrating that high expression of the hub genes was associated with poor prognosis in HCC. ROC analysis revealed its high diagnostic efficacy in both HCC and normal tissues. The proportional hazards model and calibration analysis confirmed that the model's prediction was most accurate for 1- and 3-years survival. QRT-PCR showed the high expression level of the gene signature in HCC. Our study built a novel gene signature with good potential to predict the prognosis of HCC, which may provide new therapeutic targets and molecular mechanism for HCC diagnosis and treatment.

401. Anti-Toxoplasma gondii activity of Trametes versicolor (Turkey tail) mushroom extract.

Sci Rep

2023 May 29

Sharma HN(#), Catrett J(#), Nwokeocha OD

402. Electrochemical and theoretical investigations of favipiravir drug performance as ecologically benign corrosion inhibitor for aluminum alloy in acid solution.

Sci Rep

2023 May 29

Deyab MA, El-Shamy OAA, Thabet HK

403. Perceptions and acceptability of the controlled human malaria infection (CHMI) model in The Gambia: a qualitative study.

Sci Rep

2023 May 29

Dabira ED, Fehr A, Beloum N

404. Identification of prognostic hub genes and therapeutic targets for selenium deficiency in chicks model through transcriptome profiling.

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2023 May 29

Lingamgunta LK, Aloor BP, Dasari S

405. Optically modified second harmonic generation in silicon oxynitride thin films via local layer heating.

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2023 May 29

Lukeš J, Kanclíř V, Václavík J

406. BAIAP2L2 is a novel prognostic biomarker related to migration and invasion of HCC and associated with cuprotosis.

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2023 May 29

Wei H(#), Yang J(#), Chen X(#)

407. DSF inactivator RpfB homologous FadD upregulated in Bradyrhizobium japonicum under iron limiting conditions.

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2023 May 29

Dutta K, Shityakov S, Maruyama F.

408. Fuel-cell parameter estimation based on improved gorilla troops technique.

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2023 May 29

Shaheen A, El-Sehiemy R, El-Fergany A

The parameter extraction of the proton exchange membrane fuel cells (PEMFCs) is an active study area over the past few years to achieve accurate current/voltage (I/V) curves. This work proposes an advanced version of an improved gorilla troops technique (IGTT) to precisely estimate the PEMFC's model parameters. The GTT's dual implementation of the migration approach enables boosting the exploitation phase and preventing becoming trapped in the local minima. Besides, a Tangent Flight Strategy (TFS) is incorporated with the exploitation stage for efficiently searching the search space. Using two common PEMFCs stacks of BCS 500W, and Modular SR-12, the developed IGTT is effectively applied. Furthermore, the two models are evaluated under varied partial temperature and pressure. In addition to this, different new recently inspired optimizers are employed for comparative validations namely supply demand optimization (SDO), flying foxes optimizer (FFO) and red fox optimizer (RFO). Also, a comparative assessment of the developed IGTT and the original GTT are tested to ten unconstrained benchmark functions following to the Congress on Evolutionary Computation (CEC) 2017. The proposed IGTT outperforms the standard GTT, grey wolf algorithm (GWA) and Particle swarm optimizer (PSO) in 92.5%, 87.5% and 92.5% of the statistical indices. Moreover, the viability of the IGTT is proved in comparison to various previously published frameworks-based parameter's identification of PEMFCs stacks. The obtained sum of squared errors (SSE) and the standard deviations (STD) are among the difficult approaches in this context and are quite competitive. For the PEMFCs stacks being studied, the developed IGTT achieves exceedingly small SSE values of 0.0117 and 0.000142 for BCS 500 and SR-12, respectively. Added to that, the IGTT gives superior performance compared to GTT, SDO, FFO and RFO obtaining the smallest SSE objective with the least STD ever.

409. Renal denervation reverses ventricular structural and functional remodeling in failing rabbit hearts.

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2023 May 29

Huang TC, Lo LW, Chou YH

410. Application of diffusion weighted multiple boli ASL to a murine model of human African trypanosomiasis.

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2023 May 29

Paterson S, Vallatos A, Rodgers J

411. A laboratory-based beam tracking x-ray imaging method achieving two-dimensional phase sensitivity and isotropic resolution with unidirectional undersampling.

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2023 May 29

Lioliou G, Navarrete-León C, Astolfo A

412. Production performance and rumen bacterial community structure of Hu sheep fed fermented spent mushroom substrate from Pleurotus eryngii.

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2023 May 29

Huang X(#), Zhou L(#), You X

This study aimed to investigate the effect of fermented spent mushroom substrate from Pleurotus eryngii (SMPE) supplementation on production performance, meat quality and rumen bacterial community structure of Hu sheep. 120 2-month-old Hu sheep with average body weight [(13.50 ± 3.10) kg] were selected and randomly divided into 4 groups with 3 replicates per group and 10 sheep per replicate. The control group (RL1) was fed a total mixed ration (TMR), and group RL2, RL3 and RL4 were fed the basal diets supplemented with 15%, 30% and 45% fermented SMPE, respectively. The pretest period lasted for 10 days and the test period lasted for 150 days. The results showed that: (1) Difference (p < 0.05) was observed in average daily feed intake (ADFI) and feed conversion ratio (FCR) between RL2 and RL4 groups. The eye muscle area (EMA) and grade rule (GR) values in RL2 and RL3 were significantly higher than those in RL1 and RL4 groups (p < 0.05). (2) The contents of threonine, valerine, leucine, lysine, histidine, essential amino acids, flavor amino acids, aspartic acid, serine, glutamic acid and arginine of the longissimus dorsi muscle in RL2 and RL3 groups were significantly higher than RL1 and RL4 (p < 0.05). (3) A total of 1,202,445 valid sequences were obtained from rumen of Hu sheep fed different amounts of fermented feed, and the valid sequences were clustered into 9824 Operational Taxonomic Units (OTUs). (4) α diversity analysis showed that the richness and diversity of rumen bacterial communities in Hu sheep in RL1, RL2, RL3 and RL4 groups were significantly higher than RL0 (raw materials of fermented SMPE) group (p < 0.05). β diversity analysis showed that the bacterial community structure was the most different between RL0 and RL3. (5) At the genus level, compared with RL1, the relative abundance of Christensenellaceae R-7 in RL3 group decreased significantly by 33.59%, the relative abundance of Prevotellaceae UCG001 in RL2, RL3 and RL4 decreased significantly by 50.41%, 62.24% and 49.17%, respectively, and the relative abundance of Ruminococcaceae NK4A214 in RL2 group increased significantly by 35.01% (p < 0.05). In summary, the addition of fermented SMPE to TMR can significantly improve the production performance, meat quality and rumen bacterial community diversity and abundance of Hu sheep.

413. A human-AI collaboration workflow for archaeological sites detection.

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2023 May 29

Casini L, Marchetti N, Montanucci A

414. Multiple instance learning based classification of diabetic retinopathy in weakly-labeled widefield OCTA en face images.

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2023 May 29

Matten P(#), Scherer J(#), Schlegl T

415. Experimental and computational approaches of methoxy naphthylbithiophene derivatives and their use as corrosion protection for carbon steel in acidic medium.

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2023 May 29

Fouda AES, Etaiw SH, Ismail MA

The inhibition efficiency and adsorption affinity were investigated for two novel compounds, namely: 6-methoxy-2-naphthyl-[2, 2'-bithiophene]-5-carboxamidine hydrochloride salt (MA-1440) and 5'-(4-chlorophenyl)-2, 2'-bifuran-5-carboxamidine hydrochloride salt (MA-1456). The inhibition study was conducted on carbon steel surface in 1.0 M HCl with different inhibitor doses and different temperature levels, to investigate the optimum dose and preferable temperature. The performed investigation included chemical, electrochemical, instrumental, and quantum computation techniques. A chemical technique was accomplished by using weight-loss measurements. Different factors were studied using weight-loss measurements in order to reach the maximum inhibition efficiency. The adsorption study revealed that the examined inhibitors obey the Langmuir adsorption isotherm and are chemically adsorbed on the steel surface. The electrochemical measurements were accomplished through the electrochemical impedance (EIS) and potentiodynamic polarization (PDP) techniques. Based on the electrochemical measurements, the examined compounds were categorized as mixed inhibitors. The instrumental examination using different techniques namely: scanning electron microscope (SEM), energy dispersive X-ray (EDX), Fourier-transform infrared spectroscopy (FT-IR), and X-ray photoelectron spectroscopy (XPS) confirmed that the considered inhibitors are excellently adsorbed over the carbon steel surface. The extent of the adsorption affinity of these compounds on the carbon steel surface was studied theoretically using quantum computations and Monte Carlo simulation. The theoretical investigation results of quantum chemistry were validated with those obtained by chemical and electrochemical methodologies. All investigations prove that, the tested compounds were adsorbed chemically on the steel surface and achieved maximum inhibition efficiency of, 94.69% and 90.85% for M-1440 and MA-1456, respectively, at the optimum concentration 30 [Formula: see text] 10-6 mol L-1 and temperature 328 K.

416. Entomological surveillance of invasive Aedes mosquitoes in Mazandaran Province, northern Iran from 2014 to 2020.

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2023 May 29

Nikookar SH, Charkame A, Nezammahalleh A

417. Structural insights into the bi-specific cross-over dual variable antibody architecture by cryo-EM.

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2023 May 29

Fernandez-Martinez D, Tully MD, Leonard G

418. Facile synthesis of Ag@Fe(3)O(4)/ZnO nanomaterial for label-free electrochemical detection of methemoglobin in anemic patients.

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2023 May 29

Alam A, Fatima B, Shafi S

419. Phytochemical profile and biological activities of the essential oils in the aerial part and root of Saposhnikovia divaricata.

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2023 May 29

Li B, Yang Z, Mao F

420. Encouraging adoption of green manure technology to produce clean rice product.

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2023 May 29

Valizadeh N, Jalilian S, Hallaj Z

421. Empagliflozin reduces arrhythmogenic effects in rat neonatal and human iPSC-derived cardiomyocytes and improves cytosolic calcium handling at least partially independent of NHE1.

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2023 May 29

Silva Dos Santos D, Turaça LT, Coutinho KCDS

The antidiabetic agent class of sodium-glucose cotransporter 2 (SGLT2) inhibitors confer unprecedented cardiovascular benefits beyond glycemic control, including reducing the risk of fatal ventricular arrhythmias. However, the impact of SGLT2 inhibitors on the electrophysiological properties of cardiomyocytes exposed to stimuli other than hyperglycemia remains elusive. This investigation tested the hypothesis that the SGLT2 inhibitor empagliflozin (EMPA) affects cardiomyocyte electrical activity under hypoxic conditions. Rat neonatal and human induced pluripotent stem cell (iPSC)-derived cardiomyocytes incubated or not with the hypoxia-mimetic agent CoCl2 were treated with EMPA (1 μM) or vehicle for 24 h. Action potential records obtained using intracellular microelectrodes demonstrated that EMPA reduced the action potential duration at 30%, 50%, and 90% repolarization and arrhythmogenic events in rat and human cardiomyocytes under normoxia and hypoxia. Analysis of Ca2+ transients using Fura-2-AM and contractility kinetics showed that EMPA increased Ca2+ transient amplitude and decreased the half-time to recover Ca2+ transients and relaxation time in rat neonatal cardiomyocytes. We also observed that the combination of EMPA with the Na+/H+ exchanger isoform 1 (NHE1) inhibitor cariporide (10 µM) exerted a more pronounced effect on Ca2+ transients and contractility than either EMPA or cariporide alone. Besides, EMPA, but not cariporide, increased phospholamban phosphorylation at serine 16. Collectively, our data reveal that EMPA reduces arrhythmogenic events, decreases the action potential duration in rat neonatal and human cardiomyocytes under normoxic or hypoxic conditions, and improves cytosolic calcium handling at least partially independent of NHE1. Moreover, we provided further evidence that SGLT2 inhibitor-mediated cardioprotection may be partly attributed to its cardiomyocyte electrophysiological effects.

422. Research on production capacity planning method of open-pit coal mine.

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2023 May 29

Liu G, Guo W, Chai S

423. Survey of knowledge, and attitudes to storage practices preempting the occurrence of filamentous fungi and mycotoxins in some Ghanaian staple foods and processed products.

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2023 May 29

Kortei NK, Badzi S, Nanga S

Mycotoxigenic fungi can infect and produce potent mycotoxins in foodstuffs prior to harvest, during harvest (field fungi), and in storage after harvest (storage fungi), which when ingested, can result in adverse health effects. This study was aimed at assessing the knowledge, attitudes, and practices adopted by the Ghanaian populace to help mitigate the occurrence of molds and mycotoxins in foods. A cross-sectional survey involving a structured questionnaire was conducted with 642 respondents from twelve regions of Ghana. Descriptive statistics and analyses of variance were calculated. Correct Classification Rate (CCR) was measured to assess the utility of a logistic regression model. The results of the study showed that the majority of 299 (46.6%) of the respondents were between the ages of 18-25. Age and educational level were related to knowledge about the occurrence of fungi and mycotoxins in foods (p < 0.05). More than half the respondents, 50% indicated that they knew of aflatoxins as a major mycotoxin present in food. Higher education directly influenced on the knowledge of mycotoxicosis and the management of stored food to present intoxication by fungal metabolites. 502 (32.9%) knew that consuming foods with toxins could cause stomach aches. The most commonly consumed food commodity despite the presence of visible growth of fungi was bread (35.3%). The average KAP score for knowledge showed that, out of 100%, there was adequate knowledge (63.8%) among the members of the Ghanaian populace. Favorable environmental conditions of high humidity (> 85% ERH) and temperature (> 28-32 °C) enhance the proliferation of fungi in most foods and the attendant production of mycotoxins such as aflatoxins, ochratoxins, and fumonisins are associated with several severe human and animal health conditions; mycotoxicosis was associated with high fever, pain, vomiting, suppression of immunity, cancer, etc. when these foods are consumed on regular basis for a prolonged length of time. Future examination of the food items used for the School Feeding Programme in Ghana will offer opportunities to examine the risks of feeding youth with fungal-contaminated food preparations from providers.

424. Oil tanker under ice loadings.

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2023 May 29

Gaidai O, Yan P, Xing Y

425. Bone scan index (BSI) scoring by using bone scintigraphy and circulating tumor cells (CTCs): predictive factors for enzalutamide effectiveness in patients with castration-resistant prostate cancer and bone metastases.

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2023 May 29

Hirano H, Nagata M, Nagaya N

Reports of Bone Scan Index (BSI) calculations as imaging biomarkers to predict survival in patients with metastatic castration-resistant prostate cancer (mCRPC) have been mainly from retrospective studies. To evaluate the effectiveness of enzalutamide (ENZ) in Japanese patients with mCRPC and bone metastases using BSI (bone scintigraphy) and circulating tumor cell (CTC) analysis. Prospective, single-arm study at Juntendo University affiliated hospitals, Japan. Patients were administered 160 mg ENZ daily, with 3 monthly assessments: BSI, prostate specific antigen (PSA), CTC and androgen receptor splicing variant-7 (AR-V7) status. Primary endpoint: BSI-decreasing rate after ENZ treatment. Secondary endpoints: PSA-decreasing rate and progression free survival (PFS). Statistical analyses included the Wilcoxon t-test, Cox proportional hazard regression analysis, and log-rank test. Median observation period: 17.9 months, and median PFS: 13.8 (2.0-43.9) months (n = 90 patients). A decrease in BSI compared to baseline as best BSI change on ENZ treatment was evident in 69% patients at the end of the observation period (29% patients showed a complete response, BSI 0.00). At 3 months 67% patients showed a ≥ 50% PSA reduction, and 70% after ENZ treatment. PSA decline (3 months) significantly associated with a prolonged median PFS: 18.0 (estimated) versus 6.4 months (HR 2.977 [95% CI 1.53-5.78], p = 0.001). Best BSI decline response significantly associated with a prolonged PFS: 18.1(estimated) versus 7.8 months (HR 2.045 [95% CI: 1.07-3.90], p = 0.029). CTC negative status (n = 20) significantly associated with a prolonged PFS: 13.4 [estimated] vs 8.6 months (HR 2.366, 95% CI 0.97-5.71, p = 0.041). CTC positive/AR-V7 positive status significantly associated with a shorter PFS: 5.9 months (HR 8.56, 95% CI 2.40-30.43, p = 0.0087). -reduction (3 months) and BSI-reduction (on ENZ treatment) were significant response biomarkers, and a negative CTC status was a predictive factor for ENZ efficacy in patients with mCRPC.

426. Impacts of inter-annual climate variability on reproductive phenology and postnatal development of morphological features of three sympatric bat species.

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2023 May 29

Eghbali H, Sharifi M.

Inter-annual variation in weather conditions has been shown to affect the reproductive phenological patterns of many organisms. Because of their relatively small body size and dependence on ectothermic prey, temperate-zone insectivorous bats are particularly sensitive to adverse spring environmental conditions that affect the duration of gestation and timing of parturition in these animals. This study aimed to compare phenological recruitment, birth seasonality and synchrony and morphological changes during postnatal growth in Rhinolophus euryale, Rhinolophus ferrumequinum and Myotis emarginatus in two consecutive years representing a typical dry (2015) and an extremely wet climatic event (2016) in a nursing colony in Kerend cave, western Iran. Females of these three bat species arrived from their wintering cave to the nursing colony in late April to mid-May each year. Synchrony of parturition as defined by amount clustering of births within a year assessed by circular statistics showed that for R. euryale and R. ferrumequinum the angular variance in dry year were significantly (P < 0.05) lower than in wet year, indicating a low level of synchrony in 2016. Similar comparison showed that births from M. emarginatus were highly synchrony, and there were no significant differences in timing of births among years (P > 0.05). Generalized estimating equation (GEE) for R. euryale indicated that for body mass and forearm length tests of parallelism (interaction term or growth rate) and tests for equal intercepts (y-intercepts or group term) were significant (P < 0.001). In R. ferrumequinum, the initial (y-intercepts) forearm length and body mass were not significantly (P > 0.05) different between the 2 years, but the tests for parallelism showed a significant decrease in growth rates of body mass and forearm length in the wet year (P < 0.05). Similar comparison in M. emarginatus indicated that for body mass, tests of parallelism were significantly different (P = 0.004), while tests for equal intercepts were not (P = 0.23). Our results suggest that climate changes may have unequal effects on different bat species due to differences in foraging habitat, niche partitioning, reproductive requirements and foraging strategies.

427. Microsatellite markers reveal genetic diversity and population structure of Portunus trituberculatus in the Bohai Sea, China.

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2023 May 29

Duan B, Kang T, Wan H

428. Reverse dynamics analysis of contact force and muscle activities during the golf swing after total hip arthroplasty.

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2023 May 29

Harada T, Hamai S, Hara D

429. Bending mechanics test and parameters calibration of ramie stalks.

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2023 May 29

Si S, Zhang B, Huang J

Research and development of ramie harvesting equipment is a key link to revitalize ramie industry, problems such as the tendency of stalks to tangle and clog the machine are very problematic, seriously affect the quality and fluency of the harvester. The structure of ramie stalk is complex, and the mechanical properties of each component vary greatly, collision between stalk and machine creates complex stress relationship. By building a finite element model, it is possible to analyze the stress state of the stalk during bending from a microscopic perspective, and to analyze the complex stress-strain situation within the stalk. The purpose of this paper is to establish a standard ramie stalk bending finite element model to provide a theoretical basis for the subsequent kinematics and dynamics. Firstly, material experiments were carried out on ramie straw. The structural and mechanical parameters of the straw components were obtained through measurement and calculation tests, and the force-deformation curves for straw bending were obtained. Bending finite element simulations were carried out on the basis of mechanical tests, and the parameters such as dynamic friction coefficient, wood Poisson's ratio and bast Poisson's ratio were determined by the central combination design. Then established an accurate bending finite element simulation model of ramie stalk, the accuracy of the model was verified at the end. In this paper, the key parameters of the ramie stalk model were calibrated through a combination of material tests and simulations. All parameters of the ramie stalk model were finally obtained, and the bending mechanical properties of the ramie stalk were analysed by applying finite element analysis. This bending mechanics simulation model can be used for kinematic and dynamics simulation analysis of conveying and baling to provide a theoretical basis for the structural design of the harvester. The methods explored here can be applied to other slender straw crops.

430. The relationship between serum ferritin level and clinical outcomes in sepsis based on a large public database.

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2023 May 29

He L(#), Guo C(#), Su Y

431. Dephasing by optical phonons in GaN defect single-photon emitters.

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2023 May 29

Geng Y, Luo J, van Deurzen L

Single-photon defect emitters (SPEs), especially those with magnetically and optically addressable spin states, in technologically mature wide bandgap semiconductors are attractive for realizing integrated platforms for quantum applications. Broadening of the zero phonon line (ZPL) caused by dephasing in solid state SPEs limits the indistinguishability of the emitted photons. Dephasing also limits the use of defect states in quantum information processing, sensing, and metrology. In most defect emitters, such as those in SiC and diamond, interaction with low-energy acoustic phonons determines the temperature dependence of the dephasing rate and the resulting broadening of the ZPL with the temperature obeys a power law. GaN hosts bright and stable single-photon emitters in the 600-700 nm wavelength range with strong ZPLs even at room temperature. In this work, we study the temperature dependence of the ZPL spectra of GaN SPEs integrated with solid immersion lenses with the goal of understanding the relevant dephasing mechanisms. At temperatures below ~ 50 K, the ZPL lineshape is found to be Gaussian and the ZPL linewidth is temperature independent and dominated by spectral diffusion. Above ~ 50 K, the linewidth increases monotonically with the temperature and the lineshape evolves into a Lorentzian. Quite remarkably, the temperature dependence of the linewidth does not follow a power law. We propose a model in which dephasing caused by absorption/emission of optical phonons in an elastic Raman process determines the temperature dependence of the lineshape and the linewidth. Our model explains the temperature dependence of the ZPL linewidth and lineshape in the entire 10-270 K temperature range explored in this work. The ~ 19 meV optical phonon energy extracted by fitting the model to the data matches remarkably well the ~ 18 meV zone center energy of the lowest optical phonon band ([Formula: see text]) in GaN. Our work sheds light on the mechanisms responsible for linewidth broadening in GaN SPEs. Since a low energy optical phonon band ([Formula: see text]) is a feature of most group III-V nitrides with a wurtzite crystal structure, including hBN and AlN, we expect our proposed mechanism to play an important role in defect emitters in these materials as well.

432. Prenatal exposure to benzo[a]pyrene depletes ovarian reserve and masculinizes embryonic ovarian germ cell transcriptome transgenerationally.

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2023 May 29

Lim J, Shioda T, Malott KF

433. Removing the association of random gene sets and survival time in cancers with positive random bias using fixed-point gene set.

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2023 May 29

Maghsoudi M, Aghdam R, Eslahchi C.

434. Elucidation of HHEX in pancreatic endoderm differentiation using a human iPSC differentiation model.

Sci Rep

2023 May 29

Ito R, Kimura A, Hirose Y

435. Gaidai-Xing reliability method validation for 10-MW floating wind turbines.

Sci Rep

2023 May 29

Gaidai O, Xing Y, Xu J

436. Non-linear association between body weight and functional outcome after acute ischemic stroke.

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2023 May 29

Wakisaka K, Matsuo R, Matsumoto K

437. An exploratory study of dynamic foot shape measurements with 4D scanning system.

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2023 May 27

Zhang LY, Yick KL, Yue MJ

438. Panoptic quality should be avoided as a metric for assessing cell nuclei segmentation and classification in digital pathology.

Sci Rep

2023 May 27

Foucart A, Debeir O, Decaestecker C.

439. Dynamic calibration with approximate Bayesian computation for a microsimulation of disease spread.

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2023 May 27

Asher M, Lomax N, Morrissey K

440. Seabird's cry: repertoire and vocal expression of contextual valence in the little auk (Alle alle).

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2023 May 27

Osiecka AN, Briefer EF, Kidawa D

441. Multi-channel recordings reveal age-related differences in the sleep of juvenile and adult zebra finches.

Sci Rep

2023 May 27

Yeganegi H, Ondracek JM.

442. Tuning of the band gap and dielectric loss factor by Mn doping of Zn(1-x)Mn(x)O nanoparticles.

Sci Rep

2023 May 27

Shah WH, Alam A, Javed H

443. A decision analysis model for material selection using simple ranking process.

Sci Rep

2023 May 27

Zakeri S, Chatterjee P, Konstantas D

444. Proposing magnetoimpedance effect for neuromorphic computing.

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2023 May 27

Jamilpanah L, Chiolerio A, Crepaldi M

445. Chitosan oligomers (COS) trigger a coordinated biochemical response of lemongrass (Cymbopogon flexuosus) plants to palliate salinity-induced oxidative stress.

Sci Rep

2023 May 27

Mukarram M, Khan MMA, Kurjak D

446. VEGF overexpressed mesoangioblasts enhance urethral and vaginal recovery following simulated vaginal birth in rats.

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2023 May 27

Mori da Cunha MGMC, van der Veer BK, Giacomazzi G

Vaginal birth causes pelvic floor injury which may lead to urinary incontinence. Cell therapy has been proposed to assist in functional recovery. We aim to assess if intra-arterial injection of rat mesoangioblasts (MABs) and stable Vascular Endothelial Growth Factor (VEGF)-expressing MABs, improve recovery of urethral and vaginal function following simulated vaginal delivery (SVD). Female rats (n = 86) were assigned to either injection of saline (control), allogeneic-MABs (MABsallo), autologous-MABs (MABsauto) or allogeneic-MABs transduced to stably expressed VEGF (MABsallo-VEGF). One hour after SVD, 0.5 × 106 MABs or saline were injected into the aorta. Primary outcome was urethral (7d and 14d) and vaginal (14d) function; others were bioluminescent imaging for cell tracking (1, 3 and 7d), morphometry (7, 14 and 60d) and mRNAseq (3 and 7d). All MABs injected rats had external urethral sphincter and vaginal function recovery within 14d, as compared to only half of saline controls. Functional recovery was paralleled by improved muscle regeneration and microvascularization. Recovery rate was not different between MABsallo and MABsauto. MABsallo-VEGF accelerated functional recovery and increased GAP-43 expression at 7d. At 3d we detected major transcriptional changes in the urethra of both MABsallo and MABsallo-VEGF-injected animals, with upregulation of Rho/GTPase activity, epigenetic factors and dendrite development. MABSallo also upregulated transcripts that encode proteins involved in myogenesis and downregulated pro-inflammatory processes. MABsallo-VEGF also upregulated transcripts that encode proteins involved in neuron development and downregulated genes involved in hypoxia and oxidative stress. At 7d, urethras of MABsallo-VEGF-injected rats showed downregulation of oxidative and inflammatory response compared to MABSallo. Intra-arterial injection of MABsallo-VEGF enhances neuromuscular regeneration induced by untransduced MABs and accelerates the functional urethral and vaginal recovery after SVD.

447. Optical trapping of sub-millimeter sized particles and microorganisms.

Sci Rep

2023 May 27

Lialys L, Lialys J, Salandrino A

While optical tweezers (OT) are mostly used for confining smaller size particles, the counter-propagating (CP) dual-beam traps have been a versatile method for confining both small and larger size particles including biological specimen. However, CP traps are complex sensitive systems, requiring tedious alignment to achieve perfect symmetry with rather low trapping stiffness values compared to OT. Moreover, due to their relatively weak forces, CP traps are limited in the size of particles they can confine which is about 100 μm. In this paper, a new class of counter-propagating optical tweezers with a broken symmetry is discussed and experimentally demonstrated to trap and manipulate larger than 100 μm particles inside liquid media. Our technique exploits a single Gaussian beam folding back on itself in an asymmetrical fashion forming a CP trap capable of confining small and significantly larger particles (up to 250 μm in diameter) based on optical forces only. Such optical trapping of large-size specimen to the best of our knowledge has not been demonstrated before. The broken symmetry of the trap combined with the retro-reflection of the beam has not only significantly simplified the alignment of the system, but also made it robust to slight misalignments and enhances the trapping stiffness as shown later. Moreover, our proposed trapping method is quite versatile as it allows for trapping and translating of a wide variety of particle sizes and shapes, ranging from one micron up to a few hundred of microns including microorganisms, using very low laser powers and numerical aperture optics. This in turn, permits the integration of a wide range of spectroscopy techniques for imaging and studying the optically trapped specimen. As an example, we will demonstrate how this novel technique enables simultaneous 3D trapping and light-sheet microscopy of C. elegans worms with up to 450 µm length.

448. Targeting long non-coding RNA MALAT1 reverses cancerous phenotypes of breast cancer cells through microRNA-561-3p/TOP2A axis.

Sci Rep

2023 May 27

Hajibabaei S, Nafissi N, Azimi Y

449. Eribulin inhibits growth of cutaneous squamous cell carcinoma cell lines and a novel patient-derived xenograft.

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2023 May 27

Hsu CY, Yanagi T, Maeda T

450. RNA-Seq-based transcriptome analysis of corneal endothelial cells derived from patients with Fuchs endothelial corneal dystrophy.

Sci Rep

2023 May 27

Nakagawa T(#), Tokuda Y(#), Nakano M

451. Metabolomic analysis of Mycobacterium tuberculosis reveals metabolic profiles for identification of drug-resistant tuberculosis.

Sci Rep

2023 May 27

Chaiyachat P, Kaewseekhao B, Chaiprasert A

452. Karst-bauxite formation during the Great Oxidation Event indicated by dating of authigenic rutile and its thorium content.

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2023 May 27

Cabral AR, Zeh A.

453. Performance evaluation of DEWMA3 in phase-II for capturing changes in simple linear profiles based on run rule mechanism.

Sci Rep

2023 May 27

Sherwani RAK, Qasim H, Abbas S

454. Psychometric validation for a brand-new tool for the assessment of executive functions using 360° technology.

Sci Rep

2023 May 27

Borgnis F, Borghesi F, Rossetto F

455. Observational study of the heterogeneous global meteotsunami generated after the Hunga Tonga-Hunga Ha'apai Volcano eruption.

Sci Rep

2023 May 27

Villalonga J, Amores À, Monserrat S

456. Dual synergistic inhibition of COX and LOX by potential chemicals from Indian daily spices investigated through detailed computational studies.

Sci Rep

2023 May 27

Rudrapal M, Eltayeb WA, Rakshit G

Cyclooxygenase (COX) and Lipoxygenase (LOX) are essential enzymes for arachidonic acid (AA) to eicosanoids conversion. These AA-derived eicosanoids are essential for initiating immunological responses, causing inflammation, and resolving inflammation. Dual COX/5-LOX inhibitors are believed to be promising novel anti-inflammatory agents. They inhibit the synthesis of prostaglandins (PGs) and leukotrienes (LTs), but have no effect on lipoxin formation. This mechanism of combined inhibition circumvents certain limitations for selective COX-2 inhibitors and spares the gastrointestinal mucosa. Natural products, i.e. spice chemicals and herbs, offer an excellent opportunity for drug discovery. They have proven anti-inflammatory properties. However, the potential of a molecule to be a lead/ drug candidate can be much more enhanced if it has the property of inhibition in a dual mechanism. Synergistic activity is always a better option than the molecule's normal biological activity. Herein, we have explored the dual COX/5-LOX inhibition property of the three major potent phytoconsituents (curcumin, capsaicin, and gingerol) from Indian spices using in silico tools and biophysical techniques in a quest to identify their probable inhibitory role as anti-inflammatory agents. Results revealed the dual COX/5-LOX inhibitory potential of curcumin. Gingerol and capsaicin also revealed favorable results as dual COX/5-LOX inhibitors. Our results are substantiated by target similarity studies, molecular docking, molecular dynamics, energy calculations, DFT, and QSAR studies. In experimental inhibitory (in vitro) studies, curcumin exhibited the best dual inhibitory activities against COX-1/2 and 5-LOX enzymes. Capsaicin and gingerol also showed inhibitory potential against both COX and LOX enzymes. In view of the anti-inflammatory potential these spice chemicals, this research could pave the way for more scientific exploration in this area for drug discovery.

457. Improved species level bacterial characterization from rhizosphere soil of wilt infected Punica granatum.

Sci Rep

2023 May 27

Das AJ, Sarangi AN, Ravinath R

Pomegranate crops are prone to wilt complex disease, which is known to severely hamper the crop yield. There have been limited studies that have explored bacteria-plant-host associations in wilt complex disease affecting pomegranate crops. In the present study, wilt infected rhizosphere soil samples (ISI, ASI) in pomegranate were studied in comparison to a healthy control (HSC). The 16S metagenomics sequencing approach using the MinION platform was employed for screening of bacterial communities and predictive functional pathways. Altered physicochemical properties in the soil samples were recorded showing a comparatively acidic pH in the ISI (6.35) and ASI (6.63) soil samples to the HSC soil (7.66), along with higher electrical conductivity in the ISI (139.5 µS/cm), ASI soil (180 µS/cm), HSC soil sample (123.33 µS/cm). While concentration of micronutrients such as Cl and B were significantly higher in the ISI and ASI soil as compared to the HSC, Cu and Zn were significantly higher in the ASI soil. The effectiveness and accuracy of 16S metagenomics studies in identifying beneficial and pathogenic bacterial communities in multi-pathogen-host systems depend on the completeness and consistency of the available 16S rRNA sequence repositories. Enhancing these repositories could significantly improve the exploratory potential of such studies. Thus, multiple 16S rRNA data repositories (RDP, GTDB, EzBioCloud, SILVA, and GreenGenes) were benchmarked, and the findings indicated that SILVA yields the most reliable matches. Consequently, SILVA was chosen for further analysis at the species level. Relative abundance estimates of bacterial species showed variations of growth promoting bacteria, namely, Staphylococcus epidermidis, Bacillus subtilis, Bacillus megatarium, Pseudomonas aeruginosa, Pseudomonas putida, Pseudomonas stutzeri and Micrococcus luteus. Functional profiling predictions employing PICRUSt2 revealed a number of enriched pathways such as transporter protein families involved in signalling and cellular processes, iron complex transport system substrate binding protein, peptidoglycan biosynthesis II (staphylococci) and TCA cycle VII (acetate-producers). In line with past reports, results suggest that an acidic pH along with the bioavailability of micronutrients such as Fe and Mn could be facilitating the prevalence and virulence of Fusarium oxysporum, a known causative pathogen, against the host and beneficial bacterial communities. This study identifies bacterial communities taking into account the physicochemical and other abiotic soil parameters in wilt-affected pomegranate crops. The insights obtained could be instrumental in developing effective management strategies to enhance crop yield and mitigate the impact of wilt complex disease on pomegranate crops.

458. Serum neutrophil gelatinase-associated lipocalin and lactate level during surgery predict acute kidney injury and early allograft dysfunction after liver transplantation.

Sci Rep

2023 May 27

Cho H, Jung JY, Yoon HK

459. High fibrinogen levels are associated with poor survival in patients with liposarcoma.

Sci Rep

2023 May 27

Peschek LS, Hobusch GM, Funovics PT

460. Sub-inhibitory gentamicin pollution induces gentamicin resistance gene integration in class 1 integrons in the environment.

Sci Rep

2023 May 27

Sanchez-Cid C, Ghaly TM, Gillings MR

461. Hormonal control of promoter activities of Cannabis sativa prenyltransferase 1 and 4 and salicylic acid mediated regulation of cannabinoid biosynthesis.

Sci Rep

2023 May 27

Sands LB, Haiden SR, Ma Y

462. Evaluation of the anti-inflammatory, analgesic, anti-pyretic and anti-ulcerogenic potentials of synthetic indole derivatives.

Sci Rep

2023 May 27

Siddique S, Ahmad KR, Nawaz SK

A large number of new synthetic compounds are synthesized in the field of heterocyclic chemistry having a variety of biological potentials. In the present study, some synthetic indole derivatives are used to check anti-inflammatory, analgesic, antipyretic and gastroprotective activity in albino mice. Albino mice of either sex of reproductive age were used for each study (n = 5). In anti-inflammatory activity, the negative control (NC) and positive control group animals were treated with normal saline and 10 mg/kg of indomethacin respectively. The treated groups received the twenty four different synthetic chemicals, after 30 min of sub cutaneous injection of carrageenan. In analgesic activity, hot-plate method is used and for each group the latency period was recorded at zero moment of the provision of required dose and after 30, 60, 90, 120 and 180 min. In anti-pyretic activity, Pyrexia was induced by using Brewer's yeast method. Before any treatment and then after duration of 18 h, the rectal temperatures were recorded. Among all the chemicals, only those chemicals which show any potential related to above mentioned activities were selected for gastroprotective activity. The gastroprotective activity was performed to check the gastric ulcers by using 300 mg/kg of single oral dose of indomethacin to animals of all groups except NC group. This study helped to screen out the most potent indole derivatives 3a-II and 4a-II from the 24 synthetic indole derivatives which demonstrated the best biological potential (anti-inflammatory, analgesic, antipyretic, and gastroprotection) as compared to the remaining ones. The micrometric and biochemical results also support the histological findings. Out of the twenty-four novel indole amines tested, 3a-II and 4a-II have shown the effective pharmacological capacity and additionally have not shown any overt and systemic toxicity. Thus these two indole amines need further in-depth pharmacokinetic and pharmacodynamics studies before they are recommended for any pre-clinical trial.

463. Effects of customized insoles with medial wedges on lower extremity kinematics and ultrasonographic findings in plantar fasciitis persons.

Sci Rep

2023 May 27

Thong-On S, Harutaichun P.

464. Protein biomarkers of disease progression in patients with systemic sclerosis associated interstitial lung disease.

Sci Rep

2023 May 27

Cerro-Chiang G, Ayres M, Rivas A

Systemic sclerosis is a rare connective tissue disease; and interstitial lung disease (SSc-ILD) is associated with significant morbidity and mortality. There are no clinical, radiologic features, nor biomarkers that identify the specific time when patients are at risk for progression at which the benefits from treatment outweigh the risks. Our study aimed to identify blood protein biomarkers associated with progression of interstitial lung disease in patients with SSc-ILD using an unbiased, high-throughput approach. We classified SSc-ILD as progressive or stable based on change in forced vital capacity over 12 months or less. We profiled serum proteins by quantitative mass spectrometry and analyzed the association between protein levels and progression of SSc-ILD via logistic regression. The proteins associated with at a p value of < 0.1 were queried in the ingenuity pathway analysis (IPA) software to identify interaction networks, signaling, and metabolic pathways. Through principal component analysis, the relationship between the top 10 principal components and progression was evaluated. Unsupervised hierarchical clustering with heatmapping was done to define unique groups. The cohort consisted of 72 patients, 32 with progressive SSc-ILD and 40 with stable disease with similar baseline characteristics. Of a total of 794 proteins, 29 were associated with disease progression. After adjusting for multiple testing, these associations did not remain significant. IPA identified five upstream regulators that targeted proteins associated with progression, as well as a canonical pathway with a higher signal in the progression group. Principal component analysis showed that the ten components with the highest Eigenvalues represented 41% of the variability of the sample. Unsupervised clustering analysis revealed no significant heterogeneity between the subjects. We identified 29 proteins associated with progressive SSc-ILD. While these associations did not remain significant after accounting for multiple testing, some of these proteins are part of pathways relevant to autoimmunity and fibrogenesis. Limitations included a small sample size and a proportion of immunosuppressant use in the cohort, which could have altered the expression of inflammatory and immunologic proteins. Future directions include a targeted evaluation of these proteins in another SSc-ILD cohort or application of this study design to a treatment naïve population.

465. A novel framework for the evaluation of coastal protection schemes through integration of numerical modelling and artificial intelligence into the Sand Engine App.

Sci Rep

2023 May 27

Kumar P, Leonardi N.

466. Dermatophytosis and its risk factors among children visiting dermatology clinic in Hawassa Sidama, Ethiopia.

Sci Rep

2023 May 27

Haro M, Alemayehu T, Mikiru A.

467. NCBP1 enhanced proliferation of DLBCL cells via METTL3-mediated m6A modification of c-Myc.

Sci Rep

2023 May 27

Meng S(#), Xia Y(#), Li M

468. Perfusion parameters of triphasic computed tomography hold preoperative prediction value for microvascular invasion in hepatocellular carcinoma.

Sci Rep

2023 May 27

Zhang L, Pang G, Zhang J

469. Myeloid MyD88 restricts CD8(+) T cell response to radiation therapy in pancreatic cancer.

Sci Rep

2023 May 27

Medler TR, Blair TC, Alice AF

470. Theoretical investigation on the linear and nonlinear optical properties of DAPSH crystal.

Sci Rep

2023 May 27

Valverde C, Medeiros R, Franco LR

471. Red dichromatic imaging improves visibility of bleeding during gastric endoscopic submucosal dissection.

Sci Rep

2023 May 26

Oka K, Iwai N, Okuda T

472. Drought stress memory in a germplasm of synthetic and common wheat: antioxidant system, physiological and morphological consequences.

Sci Rep

2023 May 26

Amini A, Majidi MM, Mokhtari N

Plants have evolved mechanisms of adaptation to fluctuations in their environmental conditions that have been given the term "stress memory". Synthetic wheat offers new hope for breeders to restore useful genes lost during the genetic bottleneck. We aimed to test whether drought priming and seed priming could improve drought tolerance in a diverse germplasm of synthetic and common wheat under field conditions. In this research, 27 wheat genotypes (including 20 synthetics, 4 common local and 3 common exotic bread wheat) were field evaluated under four water environments. These treatments included: 1) normal condition (N), plants were irrigated when 40% of the total available soil water was depleted from the root-zone, 2) seed priming-secondary stress (SD2), only water stress was applied at anthesis when 90% of the total available soil water was depleted and seeds were planted for evaluating, 3) primary stress- secondary stress (D1D2), primary water stress was applied at jointing stage when 70% of the total available soil water was depleted then secondary water stress was applied at the anthesis stage when 90% of the total available soil water was depleted, and 4) secondary stress (D2) only water stress was applied at the anthesis when 90% of the total available soil water was depleted. Our results indicated that improved efficient enzymatic antioxidant system leads to less yield reduction in D1D2 treatment. However, the positive effects of drought priming were more pronounced in drought primed (D1D2) than seed primed treatment (SD2). Synthetic wheat genotypes had a significant superiority in terms of yield, yield components and drought tolerance compared to common wheat genotypes. Nevertheless, the response of genotypes to stress memory was very different. Drought sensitive genotypes had better response to stress memory. Superior genotypes were identified as high yield and drought tolerant genotypes which can be used for future studies.

473. Heterologous production of the D-cycloserine intermediate O-acetyl-L-serine in a human type II pulmonary cell model.

Sci Rep

2023 May 26

Robbins L, Balaram A, Dejneka S

474. Effectiveness of bicycle helmets and injury prevention: a systematic review of meta-analyses.

Sci Rep

2023 May 26

Büth CM, Barbour N, Abdel-Aty M.

475. Improved demodulated phase signal resolution for carrier signals with small modulation index by clipping and synchronous sampling for heterodyne interferometers.

Sci Rep

2023 May 26

Yu M, Schewe M, Bauer G

476. Compliance with retainer wear using audiovisual integration and reminder: a randomized clinical trial.

Sci Rep

2023 May 26

Wafaie K, Mohammed H, Xinrui W

477. Manipulation of light spectrum is an effective tool to regulate biochemical traits and gene expression in lettuce under different replacement methods of nutrient solution.

Sci Rep

2023 May 26

Soufi HR, Roosta HR, Stępień P

478. Different MRI structural processing methods do not impact functional connectivity computation.

Sci Rep

2023 May 26

Zhang L, Pini L, Corbetta M.

479. Study on the influence mechanism of adoption of smart agriculture technology behavior.

Sci Rep

2023 May 26

Li J, Liu G, Chen Y

480. Introducing machine learning model to response surface methodology for biosorption of methylene blue dye using Triticum aestivum biomass.

Sci Rep

2023 May 26

Kumari S, Verma A, Sharma P

481. Development of a machine learning-based clinical decision support system to predict clinical deterioration in patients visiting the emergency department.

Sci Rep

2023 May 26

Choi A, Choi SY, Chung K

482. A retrospective cohort study of incidence and risk factors for severe SARS-CoV-2 breakthrough infection among fully vaccinated people.

Sci Rep

2023 May 26

Meister T, Kolde A, Fischer K

483. Plasma metabolomics of oral squamous cell carcinomas based on NMR and MS approaches provides biomarker identification and survival prediction.

Sci Rep

2023 May 26

Polachini GM(#), de Castro TB(#), Smarra LFS(#)

484. Facile photosynthesis of novel porphyrin-derived nanocomposites containing Ag, Ag/Au, and Ag/Cu for photobactericidal study.

Sci Rep

2023 May 26

Nejad ST, Rahimi R, Rabbani M

485. Nutritional and immune-related indicators-based Nomogram for predicting overall survival of surgical oral tongue squamous cell carcinoma.

Sci Rep

2023 May 26

Lin YW(#), Kang WP(#), Hong CQ(#)

486. Comprehensive analysis of the diagnostic and therapeutic value of the hypoxia-related gene PLAUR in the progression of atherosclerosis.

Sci Rep

2023 May 26

Dai C(#), Lin Y(#).

487. Reactivation of corticogenesis-related transcriptional factors BCL11B and SATB2 after ischemic lesion of the adult mouse brain.

Sci Rep

2023 May 26

Srakočić S, Gorup D, Kutlić D

488. Fish biodiversity declines with dam development in the Lower Mekong Basin.

Sci Rep

2023 May 26

Sor R, Ngor PB, Lek S

489. Risk assessment of substance use disorders based on the human leukocyte antigen (HLA).

Sci Rep

2023 May 26

James LM, Georgopoulos AP.

490. Efficacy of closed cell self expandable metallic stent for peripheral arterial disease in the porcine iliac artery.

Sci Rep

2023 May 26

Ryu DS(#), Won DS(#), Kim JW

491. Occurrence and genetic diversity of prophage sequences identified in the genomes of L. casei group bacteria.

Sci Rep

2023 May 26

Jarocki P, Komoń-Janczara E, Młodzińska A

492. Early radial positional information in the cochlea is optimized by a precise linear BMP gradient and enhanced by SOX2.

Sci Rep

2023 May 26

Thompson MJ, Young CA, Munnamalai V

Positional information encoded in signaling molecules is essential for early patterning in the prosensory domain of the developing cochlea. The sensory epithelium, the organ of Corti, contains an exquisite repeating pattern of hair cells and supporting cells. This requires precision in the morphogen signals that set the initial radial compartment boundaries, but this has not been investigated. To measure gradient formation and morphogenetic precision in developing cochlea, we developed a quantitative image analysis procedure measuring SOX2 and pSMAD1/5/9 profiles in mouse embryos at embryonic day (E)12.5, E13.5, and E14.5. Intriguingly, we found that the pSMAD1/5/9 profile forms a linear gradient up to the medial ~ 75% of the PSD from the pSMAD1/5/9 peak in the lateral edge during E12.5 and E13.5. This is a surprising activity readout for a diffusive BMP4 ligand secreted from a tightly constrained lateral region since morphogens typically form exponential or power-law gradient shapes. This is meaningful for gradient interpretation because while linear profiles offer the theoretically highest information content and distributed precision for patterning, a linear morphogen gradient has not yet been observed. Furthermore, this is unique to the cochlear epithelium as the pSMAD1/5/9 gradient is exponential in the surrounding mesenchyme. In addition to the information-optimized linear profile, we found that while pSMAD1/5/9 is stable during this timeframe, an accompanying gradient of SOX2 shifts dynamically. Last, through joint decoding maps of pSMAD1/5/9 and SOX2, we see that there is a high-fidelity mapping between signaling activity and position in the regions that will become Kölliker's organ and the organ of Corti. Mapping is ambiguous in the prosensory domain precursory to the outer sulcus. Altogether, this research provides new insights into the precision of early morphogenetic patterning cues in the radial cochlea prosensory domain.

493. Quantitative assessment of choriocapillaris flow deficits and type 1 macular neovascularization growth in age-related macular degeneration.

Sci Rep

2023 May 26

Cabral D(#), Fradinho AC(#), Zhang Y

494. Influence of hydrothermal carbonization conditions on the porosity, functionality, and sorption properties of microalgae hydrochars.

Sci Rep

2023 May 26

Kozyatnyk I, Benavente V, Weidemann E

495. Mechanical thrombectomy combined with intravenous thrombolysis for acute ischemic stroke: a systematic review and meta-analyses.

Sci Rep

2023 May 26

Zheng M, Li L, Chen L

To assess the clinical value of mechanical thrombectomy (MT) combined with intravenous thrombolysis (IVT) in acute ischemic stroke (AIS) by comparing it with the MT alone. In this study, we conducted a comprehensive meta-analysis of both observational and randomized controlled studies (RCTs) to investigate various outcomes. Our search for relevant studies was conducted between January 2011 and June 2022 in four major databases: PubMed, Embase, WOS, and Cochrane Library. We collected data on several outcomes, including functional independence (FI; defined as modified Rankin Scale score of 0 to 2), excellent outcomes (mRS 0-1), successful recanalization (SR), symptomatic intracerebral hemorrhage (sICH), any intracerebral hemorrhage (aICH), and mortality at three months or discharge. The primary efficacy outcome and safety outcome were FI and sICH, respectively, whereas excellent outcomes and SR were considered secondary efficacy outcomes. Additionally, mortality and aICH were analyzed as secondary safety outcomes. We employed the Mantel-Haenszel fixed-effects model for RCTs when I2 < 50%, otherwise the random-effects model was utilized. For observational studies and subgroup analyses, we used the random-effects model to minimize potential bias. A total of 55 eligible studies (nine RCTs and 46 observational studies) were included. For RCTs, the MT + IVT group was superior in FI (OR: 1.27, 95% CI: 1.11-1.46), excellent outcomes (OR: 1.21, 95% CI: 1.03-1.43), SR (OR: 1.23, 95% CI: 1.05-1.45), mortality (OR: 0.72, 95% CI: 0.54-0.97) in crude analyses. In adjusted analyses, the MT + IVT group reduced the risk of mortality (OR: 0.65, 95% CI: 0.49-0.88). However, the difference in FI between the MT + IVT group and the MT alone group was not significant (OR: 1.17, 95% CI: 0.99-1.38, Fig. 3a). For observational studies, the results of FI (OR: 1.34, 95% CI: 1.16-1.33), excellent outcomes (OR: 1.30, 95% CI: 1.09-1.54), SR (OR: 1.23, 95% CI: 1.05-1.44), mortality (OR: 0.70, 95% CI: 0.64-0.77) in the MT + IVT group were better. Additionally, the MT + IVT group increased the risk of hemorrhagic transformation (HT) including sICH (OR: 1.16, 95% CI: 1.11-1.21) and aICH (OR: 1.24, 95% CI: 1.05-1.46) in crude analyses. In adjusted analyses, significant better outcomes were seen in the MT + IVT group on FI (OR: 1.36, 95% CI: 1.21-1.52), excellent outcomes (OR: 1.49, 95% CI: 1.26-1.75), and mortality (OR: 0.73, 95% CI: 0.56-0.94). The MT + IVT therapy did improve the prognosis for AIS patients and did not increase the risk of HT compared with MT alone therapy.

496. Efficient utilization of red mud waste via stepwise leaching to obtain α-hematite and mesoporous γ-alumina.

Sci Rep

2023 May 26

Karimi Z, Rahbar-Kelishami A.

497. Evaluation of motion artefact reduction depending on the artefacts' directions in head MRI using conditional generative adversarial networks.

Sci Rep

2023 May 26

Usui K, Muro I, Shibukawa S

Motion artefacts caused by the patient's body movements affect magnetic resonance imaging (MRI) accuracy. This study aimed to compare and evaluate the accuracy of motion artefacts correction using a conditional generative adversarial network (CGAN) with an autoencoder and U-net models. The training dataset consisted of motion artefacts generated through simulations. Motion artefacts occur in the phase encoding direction, which is set to either the horizontal or vertical direction of the image. To create T2-weighted axial images with simulated motion artefacts, 5500 head images were used in each direction. Of these data, 90% were used for training, while the remainder were used for the evaluation of image quality. Moreover, the validation data used in the model training consisted of 10% of the training dataset. The training data were divided into horizontal and vertical directions of motion artefact appearance, and the effect of combining this data with the training dataset was verified. The resulting corrected images were evaluated using structural image similarity (SSIM) and peak signal-to-noise ratio (PSNR), and the metrics were compared with the images without motion artefacts. The best improvements in the SSIM and PSNR were observed in the consistent condition in the direction of the occurrence of motion artefacts in the training and evaluation datasets. However, SSIM > 0.9 and PSNR > 29 dB were accomplished for the learning model with both image directions. The latter model exhibited the highest robustness for actual patient motion in head MRI images. Moreover, the image quality of the corrected image with the CGAN was the closest to that of the original image, while the improvement rates for SSIM and PSNR were approximately 26% and 7.7%, respectively. The CGAN model demonstrated a high image reproducibility, and the most significant model was the consistent condition of the learning model and the direction of the appearance of motion artefacts.

498. Abdominal perfusion pressure in critically ill cirrhotic patients: a prospective observational study.

Sci Rep

2023 May 26

Pereira RA, Esteves AF, Cardoso FS

499. Deep ultraviolet fluorescence microscopy of three-dimensional structures in the mouse brain.

Sci Rep

2023 May 26

Kasaragod DK, Aizawa H.

500. Specific mating behavior of Malayan pangolin (Manis javanica) in captivity.

Sci Rep

2023 May 26

Yan D(#), Guo X(#), Zeng X

501. GC-MS based untargeted metabolomics reveals the metabolic response of earthworm (Eudrilus eugeniae) after chronic combinatorial exposure to three different pesticides.

Sci Rep

2023 May 26

Malla MA, Dubey A(#), Kori RK(#)

502. Task-relevant social cues affect whole-body approach-avoidance behavior.

Sci Rep

2023 May 26

Welsch R, Hecht H, Stins J.

503. A geospatial platform for the tectonic interpretation of low-temperature thermochronology Big Data.

Sci Rep

2023 May 26

Boone SC, Kohlmann F, Noble W

504. Intermunicipal travel networks of Mexico during the COVID-19 pandemic.

Sci Rep

2023 May 26

Fontanelli O, Guzmán P, Meneses-Viveros A

505. Microbial growth and adhesion of Escherichia coli in elastomeric silicone foams with commonly used additives.

Sci Rep

2023 May 26

Rebane I, Priks H, Levin KJ

506. Patients' preferences in therapeutic decision-making in digestive oncology: a single centre cross-sectional observational study.

Sci Rep

2023 May 26

Nizet P, Grivel C, Rabeau P

507. Dietary antioxidants and liver enzymes in Rafsanjan, a Region in Southeast Iran.

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2023 May 26

Khademalhosseini M, Ranjbar E, Mohammadi R

Sci Rep

2023 May 26

Wilczek J, Jadczyk T, Wojakowski W

509. Machine learning survival models trained on clinical data to identify high risk patients with hormone responsive HER2 negative breast cancer.

Sci Rep

2023 May 26

Fanizzi A(#), Pomarico D(#), Rizzo A

510. Simulation of melting paraffin with graphene nanoparticles within a solar thermal energy storage system.

Sci Rep

2023 May 26

Jafaryar M, Sheikholeslami M.

511. Experimental hierarchy of two-qubit quantum correlations without state tomography.

Sci Rep

2023 May 26

Abo S, Soubusta J, Jiráková K

512. Phase I randomized, observer-blinded, placebo-controlled study of a SARS-CoV-2 mRNA vaccine PTX-COVID19-B.

Sci Rep

2023 May 26

Martin-Orozco N, Vale N, Mihic A

Access to vaccines against SARS-CoV-2 virus was limited in poor countries during the COVID-19 pandemic. Therefore, a low-cost mRNA vaccine, PTX-COVID19-B, was produced and evaluated in a Phase 1 trial. PTX-COVID19-B encodes Spike protein D614G variant without the proline-proline (986-987) mutation present in other COVID-19 vaccines. The aim of the study was to evaluate safety, tolerability, and immunogenicity of PTX-COVID19-B vaccine in healthy seronegative adults 18-64 years old. The trial design was observer-blinded, randomized, placebo-controlled, and tested ascending doses of 16-µg, 40-µg, or 100-µg in a total of 60 subjects who received two intramuscular doses, 4 weeks apart. Participants were monitored for solicited and unsolicited adverse events after vaccination and were provided with a Diary Card and thermometer to report any reactogenicity during the trial. Blood samples were collected on baseline, days 8, 28, 42, 90, and 180 for serum analysis of total IgG anti-receptor binding domain (RBD)/Spike titers by ELISA, and neutralizing antibody titers by pseudovirus assay. Titers in BAU/mL were reported as geometric mean and 95% CI per cohort. After vaccination, few solicited adverse events were observed and were mild to moderate and self-resolved within 48 h. The most common solicited local and systemic adverse event was pain at the injection site, and headache, respectively. Seroconversion was observed in all vaccinated participants, who showed high antibody titers against RBD, Spike, and neutralizing activity against the Wuhan strain. Neutralizing antibody titers were also detected against Alpha, Beta, and Delta variants of concerns in a dose dependent manner. All tested doses of PTX-COVID19-B were safe, well-tolerated, and provided a strong immunogenicity response. The 40-µg dose showed fewer adverse reactions than the 100-µg dose, and therefore was selected for a Phase 2 trial, which is currently ongoing.Clinical Trial Registration number: NCT04765436 (21/02/2021). ( https://clinicaltrials.gov/ct2/show/NCT04765436 ).

513. Differences in the transcriptional immune response to Albugo candida between white rust resistant and susceptible cultivars in Brassica rapa L.

Sci Rep

2023 May 26

Miyaji N(#), Akter MA(#), Shimizu M

514. IL5RA as an immunogenic cell death-related predictor in progression and therapeutic response of multiple myeloma.

Sci Rep

2023 May 26

Xu C(#), Gao M(#), Zhang J

515. Nanoscale thermal control of a single living cell enabled by diamond heater-thermometer.

Sci Rep

2023 May 26

Romshin AM, Zeeb V, Glushkov E

516. Neural-fuzzy machine learning approach for the fatigue-creep reliability modeling of SAC305 solder joints.

Sci Rep

2023 May 26

Bani Hani D, Al Athamneh R, Abueed M

The accuracy of reliability models is one of the most problematic issues that must be considered for the life of electronic assemblies, particularly those used for critical applications. The reliability of electronics is limited by the fatigue life of interconnected solder materials, which is influenced by many factors. This paper provides a method to build a robust machine-learning reliability model to predict the life of solder joints in common applications. The impacts of combined fatigue and creep stresses on solder joints are also investigated in this paper. The common alloy used in solder joint fabrication is SAC305 (Sn-Ag-Cu). The test vehicle includes individual solder joints of SAC305 alloy assembled on a printed circuit board. The effects of testing temperature, stress amplitude, and creep dwell time on the life of solder joints were considered. A two-parameter Weibull distribution was utilized to analyze the fatigue life. Inelastic work and plastic strain were extracted from the stress-strain curves. Then, Artificial Neural Networks (ANNs) were used to build a machine learning model to predict characteristic life obtained from the Weibull analysis. The inelastic work and plastic stains were also considered in the ANN model. Fuzzy logic was used to combine the process parameters and fatigue properties and to construct the final life prediction model. Then a relationship equation between the comprehensive output measure obtained from the fuzzy system and the life was determined using a nonlinear optimizer. The results indicated that increasing the stress level, testing temperature, and creep dwell time decreases reliability. The case of long creep dwell time at elevated temperatures is worst in terms of impact on reliability. Finally, a single robust reliability model was computed as a function of the fatigue properties and process parameters. A significant enhancement of the prediction model was achieved compared to the stress-life equations.

517. Patterns of shade plant diversity in four agroforestry systems across Central America: a meta-analysis.

Sci Rep

2023 May 26

Esquivel MJ, Vilchez-Mendoza S, Harvey CA

518. Constructing a disease database and using natural language processing to capture and standardize free text clinical information.

Sci Rep

2023 May 26

Raza S, Schwartz B.

519. Two-step crystallisation in a 2D active magnetic granular system confined by a parabolic potential.

Sci Rep

2023 May 26

Escobar A, Ledesma-Motolinía M, Carrillo-Estrada JL

520. RNA ligase ribozymes with a small catalytic core.

Sci Rep

2023 May 26

Nomura Y, Yokobayashi Y.

521. Spatial fragmentation in the distribution of diatom endosymbionts from the taxonomically clarified dinophyte Kryptoperidinium triquetrum (= Kryptoperidinium foliaceum, Peridiniales).

Sci Rep

2023 May 26

Tillmann U, Wietkamp S, Kretschmann J

522. Decoding the physiological response of plants to stress using deep learning for forecasting crop loss due to abiotic, biotic, and climatic variables.

Sci Rep

2023 May 26

Kumar M, Saifi Z, Krishnananda SD.

523. Changes in selected exerkines concentration post folk-dance training are accompanied by glucose homeostasis and physical performance improvement in older adults.

Sci Rep

2023 May 26

Rodziewicz-Flis EA(#), Kawa M(#), Kaczor JJ

524. Hospital admissions and deaths due to acute cardiovascular events during the COVID-19 pandemic in residents of long-term care facilities.

Sci Rep

2023 May 26

Gellert P, Kohl R, Jürchott K

525. Magneto-strain effects in 2D ferromagnetic van der Waal material CrGeTe[Formula: see text].

Sci Rep

2023 May 26

Vijay K, Vavilapalli DS, Arya A

526. Comparative toxicity of two neonicotinoid insecticides at environmentally relevant concentrations to telecoprid dung beetles.

Sci Rep

2023 May 26

Cavallaro MC, Hladik ML, Hittson S

527. There are unique kinematics during locomotor transitions between level ground and stair ambulation that persist with increasing stair grade.

Sci Rep

2023 May 26

Neuman RM, Fey NP.

528. Evolution of surface area and membrane shear modulus of matured human red blood cells during mechanical fatigue.

Sci Rep

2023 May 26

Wei Q, Wang X, Zhang C

529. Application of quality-by-design for adopting an environmentally green fluorogenic determination of benoxinate hydrochloride in eye drops and artificial aqueous humour.

Sci Rep

2023 May 26

El Hamd MA, El-Maghrabey M, Magdy G

530. Ir impurities in [Formula: see text]- and [Formula: see text]-[Formula: see text] and their detrimental effect on p-type conductivity.

Sci Rep

2023 May 26

Zachinskis A, Grechenkov J, Butanovs E

531. Estimation of drinking water volume of laboratory animals based on image processing.

Sci Rep

2023 May 26

Liu Z, Liu F, Zeng Q

532. Estimated dietary intake of polyphenols from cereal foods and associated lifestyle and demographic factors in the Melbourne Collaborative Cohort Study.

Sci Rep

2023 May 26

Vingrys K, Mathai ML, Apostolopoulos V

533. Whole exome and transcriptome analysis revealed the activation of ERK and Akt signaling pathway in canine histiocytic sarcoma.

Sci Rep

2023 May 25

Asada H(#), Tani A(#), Sakuma H(#)

534. Multi biomarker approach to assess manganese and manganese nanoparticles toxicity in Pangasianodon hypophthalmus.

Sci Rep

2023 May 25

Kumar N, Thorat ST, Reddy KS.

Manganese (Mn) is an essential element for humans and animals including, fish. It is a still poorly studied in aquatic organisms, where it can be noticeably useful for dietary components and also found pollutant in aquatic environment at high concentrations. On the above information, an experiment was delineated to determine the lethal concentration of manganese (Mn) and manganese nanoparticles (Mn-NPs) alone and with high temperature (34 °C) and its effect on various biochemical markers in Pangasianodon hypophthalmus. The median lethal concentration (96-LC50) of Mn alone (111.75 mg L-1) and along with high temperature (110.76 mg L-1), Mn-NPs alone (93.81 mg L-1) and with high temperature (34 °C) (92.39 mg L-1) was determined in P. hypophthalmus. The length and weight of the fish were 6.32 ± 0.23 cm and 7.57 ± 1.35 g. The present investigation used five hundred forty-six fish, including range finding (216 fish) and definitive test (330 fish). The acute definitive doses were applied to assess the effect of oxidative stress, glycolytic biomarkers, protein biomarkers, fish immunity, neurotransmitter, energy level, stress hormone and histopathology. Oxidative stress (catalase, superoxide dismutase, glutathione-s-transferase and glutathione peroxidase), stress biomarkers (lipid peroxidation, cortisol, heat shock protein, and blood glucose), lactate and malate dehydrogenase, alanine and aspartate aminotransferase, a neurotransmitter, glucose-6-phosphate dehydrogenase (G6PDH), ATPase, immune system biomarkers (NBT, total protein, albumin, globulin and A:G ratio) were altered with exposure to Mn and Mn-NPs. The histopathology of the liver and gill were also changed due to exposure to Mn and Mn-NPs. The bioaccumulation of Mn in the liver, gill, kidney, brain and muscle tissues, and experimental water at different intervals of 24, 48, 72 and 96 h were determined. Based on the present results, it is strongly suggested that Mn and Mn-NPs exposure alone and with high temperature (34 °C) enhanced toxicity and altered biochemical and morphological attributes. This study also suggested that essential elements in both forms (inorganic and nano) at higher concentrations of Mn and Mn-NPs lead to pronounced deleterious alteration in cellular and metabolic activities and histopathology of P. hypophthalmus.

535. Rapid TCR:Epitope Ranker (RAPTER): a primary human T cell reactivity screening assay pairing epitope and TCR at single cell resolution.

Sci Rep

2023 May 25

Deering RP, Blumenberg L, Li L

536. GO nanoparticles mitigate the negative effects of salt and alkalinity stress by enhancing gas exchange and photosynthetic efficiency of strawberry plants.

Sci Rep

2023 May 25

Malekzadeh MR, Roosta HR, Kalaji HM.

537. Subpopulations of hypocretin/orexin neurons differ in measures of their cell proliferation, dynorphin co-expression, projections, and response to embryonic ethanol exposure.

Sci Rep

2023 May 25

Yasmin N, Collier AD, Karatayev O

538. Entomotoxic efficacy of fungus-synthesized nanoparticles against immature stages of stored bean pests.

Sci Rep

2023 May 25

Helmy EAM, San PP, Zhang YZ

539. Predicting lymphovascular invasion in rectal cancer: evaluating the performance of golden-angle radial sparse parallel MRI for rectal perfusion assessment.

Sci Rep

2023 May 25

Fan Y, Chen M, Huang H

540. New evidence for the Ontong Java Nui hypothesis.

Sci Rep

2023 May 25

Tejada MLG, Sano T, Hanyu T

541. Wolbachia protects Drosophila melanogaster against two naturally occurring and virulent viral pathogens.

Sci Rep

2023 May 25

Bruner-Montero G, Jiggins FM.

542. Time-series analysis of satellite imagery for detecting vegetation cover changes in Indonesia.

Sci Rep

2023 May 25

Furusawa T, Koera T, Siburian R

543. Automated screening of potential organ donors using a temporal machine learning model.

Sci Rep

2023 May 25

Sauthier N, Bouchakri R, Carrier FM

544. Emerging solutions from the battle of defensive alliances.

Sci Rep

2023 May 25

Szolnoki A, Chen X.

545. Identification, characterization, and prognosis investigation of pivotal genes shared in different stages of breast cancer.

Sci Rep

2023 May 25

Rommasi F.

One of the leading causes of death (20.1 per 100,000 women per year), breast cancer is the most prevalent cancer in females. Statistically, 95% of breast cancer are categorized as adenocarcinomas, and 55% of all patients may go into invasive phases; however, it can be successfully treated in approximately 70-80% of cases if diagnosed in the nascent stages. The emergence of breast tumor cells which are intensely resistant to conventional therapies, along with the high rate of metastasis occurrence, has highlighted the importance of finding novel strategies and treatments. One of the most advantageous schemes to alleviate this complication is to identify the common differentially expressed genes (DEGs) among primary and metastatic cancerous cells to use resultants for designing new therapeutic agents which are able to target both primary and metastatic breast tumor cells. In this study, the gene expression dataset with accession number GSE55715 was analyzed containing two primary tumor samples, three bone-metastatic samples, and three normal samples to distinguish the up- and down regulated genes in each stage compared to normal cells as control. In the next step, the common upregulated genes between the two experimental groups were detected by Venny online tool. Moreover, gene ontology, functions and pathways, gene-targeting microRNA, and influential metabolites were determined using EnrichR 2021 GO, KEGG pathways miRTarbase 2017, and HMDB 2021, respectively. Furthermore, elicited from STRING protein-protein interaction networks were imported to Cytoscape software to identify the hub genes. Then, identified hub genes were checked to validate the study using oncological databases. The results of the present article disclosed 1263 critical common DEGs (573 upregulated + 690 downregulated), including 35 hub genes that can be broadly used as new targets for cancer treatment and as biomarkers for cancer detection by evaluation of expression level. Besides, this study opens a new horizon to reveal unknown aspects of cancer signaling pathways by providing raw data evoked from in silico experiments. This study's outcomes can also be widely utilized in further lab research since it contains diverse information on common DEGs of varied stages and metastases of breast cancer, their functions, structures, interactions, and associations.

546. A report of Kabul internet users on self-medication with over-the-counter medicines.

Sci Rep

2023 May 25

Nemat A, Rezayee KJ, Essar MY

547. Simultaneous selection of multiple important single nucleotide polymorphisms in familial genome wide association studies data.

Sci Rep

2023 May 25

Majumdar S, Basu S, McGue M

548. Transcriptomic and metabolic studies on the role of inorganic and organic iodine compounds in lettuce plants.

Sci Rep

2023 May 25

Smoleń S, Czernicka M, Kęska-Izworska K

549. Chemical modification of AAV9 capsid with N-ethyl maleimide alters vector tissue tropism.

Sci Rep

2023 May 25

Mulcrone PL(#), Lam AK(#), Frabutt D

550. Combined cerium and zinc oxide nanoparticles induced hepato-renal damage in rats through oxidative stress mediated inflammation.

Sci Rep

2023 May 25

Adeniyi OE, Adebayo OA, Akinloye O

551. The nonlinear energy model and stress-strain model of sandstone.

Sci Rep

2023 May 25

Zheng Z, Yang Y, Pan C.

552. Simple combination of multiple somatic variant callers to increase accuracy.

Sci Rep

2023 May 25

Trevarton AJ, Chang JT, Symmans WF.

553. Rab27a-mediated extracellular vesicle secretion contributes to osteogenesis in periodontal ligament-bone niche communication.

Sci Rep

2023 May 25

Lu Y(#), Zhao L(#), Mao J

554. Classification of odors associated with migraine attacks: a cross-sectional study.

Sci Rep

2023 May 25

Imai N, Osanai A, Moriya A

555. The application of non-uniform magnetic field for thermal enhancement of the nanofluid flow inside the U-turn pipe at solar collectors.

Sci Rep

2023 May 25

Li S, Mao L, Alizadeh A

556. Structural assessment of the full-length wild-type tumor suppressor protein p53 by mass spectrometry-guided computational modeling.

Sci Rep

2023 May 25

Di Ianni A(#), Tüting C(#), Kipping M

557. Sex differences in VTA GABA transmission and plasticity during opioid withdrawal.

Sci Rep

2023 May 25

Kalamarides DJ, Singh A, Wolfman SL

558. Heart rate variability changes with respect to time and exercise intensity during heart-rate-controlled steady-state treadmill running.

Sci Rep

2023 May 25

Brockmann L, Hunt KJ.

559. Dietary exposure to potentially harmful elements in edible plants in Poland and the health risk dynamics related to their geochemical differentiation.

Sci Rep

2023 May 25

Wódkowska A, Gruszecka-Kosowska A.

560. Taxonogenomics of Culturomica massiliensis gen. nov., sp. nov., and Emergencia timonensis gen. nov., sp. nov. new bacteria isolated from human stool microbiota.

Sci Rep

2023 May 25

Hamame A, Magdy Wasfy R, Lo CI

561. New molecular structure based models for estimation of the CO(2) solubility in different choline chloride-based deep eutectic solvents (DESs).

Sci Rep

2023 May 25

Dehkordi F, Sobati MA, Gorji AE.

562. Fabrication of plane-type axon guidance substrates by applying diamond-like carbon thin film deposition.

Sci Rep

2023 May 25

Ban M, Chen J.

563. Ikaros expression is associated with an increased risk of chronic graft-versus-host disease.

Sci Rep

2023 May 25

Pereira AD, de Molla VC, Fonseca ARBM

Immune reconstitution after hematopoietic stem cell transplantation (HSCT) is a complex and extremely variable process. The Ikaros transcription factor plays an important role in hematopoiesis in several cell lines, especially in the lymphoid lineage. We hypothesized that Ikaros might influence immune reconstitution, and consequently, the risk of opportunistic infections, relapse, and graft versus host disease (GVHD). Samples were collected from the graft and from the peripheral blood (PB) of the recipients 3 weeks after neutrophil recovery. Real-time polymerase chain reaction (RT-PCR) was performed to analyze the absolute and relative Ikaros expression. Patients were divided into two groups, according to Ikaros expression in the graft and in the recipients' PB based on the ROC curves for moderate/severe cGVHD. A cutoff of 1.48 was used for Ikaros expression in the graft, and a cutoff of 0.79 was used for Ikaros expression in the recipients' PB. Sixty-six patients were included in this study. Median age of patients was 52 years (range 16-80 years), 55% of them were male, and 58% of them had acute leukemia. Median follow-up period was 18 months (range 10-43 months). There was no association between Ikaros expression and the risk of acute GVHD, relapse, or mortality. However, a significant association was observed with the risk of chronic GVHD. Higher Ikaros expression in the graft was associated with a significantly higher cumulative incidence (CI) of moderate/severe chronic GVHD according to the National Institute of Health (NIH) classification at two years (54% vs. 15% for patients with lower expression, P = 0.03). A higher Ikaros expression in the recipients' PB 3 weeks after engraftment was also associated with a significantly higher risk of moderate/severe chronic GVHD (65% vs. 11%, respectively, P = 0.005). In conclusion, Ikaros expression in the graft and in the recipients' PB after transplantation was associated with a higher risk of moderate/severe chronic GVHD. Ikaros expression should be evaluated in larger prospective trials as a potential biomarker for chronic GVHD.

564. An antioxidation strategy based on ultra-small nanobubbles without exogenous antioxidants.

Sci Rep

2023 May 25

Zheng J(#), Qi J(#), Song S

565. Deciphering of seed Health of common food grains (wheat, rice) of North Eastern UP and Gurgaon Haryana, India.

Sci Rep

2023 May 25

Kumar N, Khurana SMP, Pandey VN.

566. Learning without forgetting by leveraging transfer learning for detecting COVID-19 infection from CT images.

Sci Rep

2023 May 25

Subramanian M, Sathishkumar VE, Cho J

567. Solar power forecasting beneath diverse weather conditions using GD and LM-artificial neural networks.

Sci Rep

2023 May 25

Sharma N, Puri V, Mahajan S

Large-scale solar energy production is still a great deal of obstruction due to the unpredictability of solar power. The intermittent, chaotic, and random quality of solar energy supply has to be dealt with by some comprehensive solar forecasting technologies. Despite forecasting for the long-term, it becomes much more essential to predict short-term forecasts in minutes or even seconds prior. Because key factors such as sudden movement of the clouds, instantaneous deviation of temperature in ambiance, the increased proportion of relative humidity and uncertainty in the wind velocities, haziness, and rains cause the undesired up and down ramping rates, thereby affecting the solar power generation to a greater extent. This paper aims to acknowledge the extended stellar forecasting algorithm using artificial neural network common sensical aspect. Three layered systems have been suggested, consisting of an input layer, hidden layer, and output layer feed-forward in conjunction with back propagation. A prior 5-min te output forecast fed to the input layer to reduce the error has been introduced to have a more precise forecast. Weather remains the most vital input for the ANN type of modeling. The forecasting errors might enhance considerably, thereby affecting the solar power supply relatively due to the variations in the solar irradiations and temperature on any forecasting day. Prior approximation of stellar radiations exhibits a small amount of qualm depending upon climatic conditions such as temperature, shading conditions, soiling effects, relative humidity, etc. All these environmental factors incorporate uncertainty regarding the prediction of the output parameter. In such a case, the approximation of PV output could be much more suitable than direct solar radiation. This paper uses Gradient Descent (GD) and Levenberg Maquarndt Artificial Neural Network (LM-ANN) techniques to apply to data obtained and recorded milliseconds from a 100 W solar panel. The essential purpose of this paper is to establish a time perspective with the greatest deal for the output forecast of small solar power utilities. It has been observed that 5 ms to 12 h time perspective gives the best short- to medium-term prediction for April. A case study has been done in the Peer Panjal region. The data collected for four months with various parameters have been applied randomly as input data using GD and LM type of artificial neural network compared to actual solar energy data. The proposed ANN based algorithm has been used for unswerving petite term forecasting. The model output has been presented in root mean square error and mean absolute percentage error. The results exhibit a improved concurrence between the forecasted and real models. The forecasting of solar energy and load variations assists in fulfilling the cost-effective aspects.

568. Association between food-based dietary inflammatory potential and ulcerative colitis: a case-control study.

Sci Rep

2023 May 25

Khademi Z, Saneei P, Hassanzadeh-Keshteli A

569. Stratification of responses to tDCS intervention in a healthy pediatric population based on resting-state EEG profiles.

Sci Rep

2023 May 25

Dagnino PC(#), Braboszcz C, Kroupi E

Transcranial Direct Current Stimulation (tDCS) is a non-invasive neuromodulation technique with a wide variety of clinical and research applications. As increasingly acknowledged, its effectiveness is subject dependent, which may lead to time consuming and cost ineffective treatment development phases. We propose the combination of electroencephalography (EEG) and unsupervised learning for the stratification and prediction of individual responses to tDCS. A randomized, sham-controlled, double-blind crossover study design was conducted within a clinical trial for the development of pediatric treatments based on tDCS. The tDCS stimulation (sham and active) was applied either in the left dorsolateral prefrontal cortex or in the right inferior frontal gyrus. Following the stimulation session, participants performed 3 cognitive tasks to assess the response to the intervention: the Flanker Task, N-Back Task and Continuous Performance Test (CPT). We used data from 56 healthy children and adolescents to implement an unsupervised clustering approach that stratify participants based on their resting-state EEG spectral features before the tDCS intervention. We then applied a correlational analysis to characterize the clusters of EEG profiles in terms of participant's difference in the behavioral outcome (accuracy and response time) of the cognitive tasks when performed after a tDCS-sham or a tDCS-active session. Better behavioral performance following the active tDCS session compared to the sham tDCS session is considered a positive intervention response, whilst the reverse is considered a negative one. Optimal results in terms of validity measures was obtained for 4 clusters. These results show that specific EEG-based digital phenotypes can be associated to particular responses. While one cluster presents neurotypical EEG activity, the remaining clusters present non-typical EEG characteristics, which seem to be associated with a positive response. Findings suggest that unsupervised machine learning can be successfully used to stratify and eventually predict responses of individuals to a tDCS treatment.

570. Hedgehog morphogen gradient is robust towards variations in tissue morphology in Drosophila.

Sci Rep

2023 May 25

Pierini G, Dahmann C.

571. Prediction and experimental evidence of different growth phases of the Podospora anserina hyphal network.

Sci Rep

2023 May 25

Ledoux C, Chapeland-Leclerc F, Ruprich-Robert G

572. A new basic probability assignment generation and combination method for conflict data fusion in the evidence theory.

Sci Rep

2023 May 25

Tang Y, Zhou Y, Ren X

573. Structural evolution of metatitanic acid and iron removal during hydrolysis of industrial TiOSO(4) solution.

Sci Rep

2023 May 25

Tian C, Ma G, Ge H.

574. Decomposition of musculoskeletal structures from radiographs using an improved CycleGAN framework.

Sci Rep

2023 May 25

Nakanishi N, Otake Y, Hiasa Y

575. Distinguishing intentional from nonintentional actions through eeg and kinematic markers.

Sci Rep

2023 May 25

Derchi CC(#), Mikulan E(#), Mazza A

576. Uric acid level in climacteric women and its association with clinical and metabolic parameters.

Sci Rep

2023 May 25

Cota E Souza LA, D'Angelo GCO, da Silva GN

577. Stochastic gradient descent for optimization for nuclear systems.

Sci Rep

2023 May 25

Williams A, Walton N, Maryanski A

578. Compensatory mechanisms of reduced interhemispheric EEG connectivity during sleep in patients with apnea.

Sci Rep

2023 May 25

Zhuravlev M, Agaltsov M, Kiselev A

579. DNA fragmentation and multifaceted toxicity induced by high-dose vanadium exposure determined by the bioindicator Allium test.

Sci Rep

2023 May 25

Kaya M, Çavuşoğlu K, Yalçin E

580. Coincidence measurements of two quantum-correlated photon pairs widely separated in the frequency domain.

Sci Rep

2023 May 25

Hojo M, Tani S, Kobayashi Y

581. Cough sound-based estimation of vital capacity via cough peak flow using artificial neural network analysis.

Sci Rep

2023 May 25

Umayahara Y, Soh Z, Furui A

582. Investigating how immersive virtual reality and active navigation mediate the experience of virtual concerts.

Sci Rep

2023 May 25

Lo SY, Lai CY.

583. Biometric and gonadosomatic indices and chemical constituents of edible tissues and exoskeletons of Callinectes amnicola and their potential for reuse in the circular economy paradigm.

Sci Rep

2023 May 25

Jolaosho TL, Elegbede IO, Akintola SL

584. Synthesis of prebiotic organics from CO(2) by catalysis with meteoritic and volcanic particles.

Sci Rep

2023 May 25

Peters S, Semenov DA, Hochleitner R

585. Transcriptomics-based investigation of manganese dioxide nanoparticle toxicity in rats' choroid plexus.

Sci Rep

2023 May 25

Memg CY, Ma XY, Xu MY

Manganese dioxide nanoparticles (MnO2-NPs) have a wide range of applications in biomedicine. Given this widespread usage, it is worth noting that MnO2-NPs are definitely toxic, especially to the brain. However, the damage caused by MnO2-NPs to the choroid plexus (CP) and to the brain after crossing CP epithelial cells has not been elucidated. Therefore, this study aims to investigate these effects and elucidate potential underlying mechanisms through transcriptomics analysis. To achieve this objective, eighteen SD rats were randomly divided into three groups: the control group (control), low-dose exposure group (low-dose) and high-dose exposure group (high-dose). Animals in the two treated groups were administered with two concentrations of MnO2-NPs (200 mg kg-1 BW and 400 mg kg-1 BW) using a noninvasive intratracheal injection method once a week for three months. Finally, the neural behavior of all the animals was tested using a hot plate tester, open-field test and Y-type electric maze. The morphological characteristics of the CP and hippocampus were observed by H&E stain, and the transcriptome of CP tissues was analysed by transcriptome sequencing. The representative differentially expressed genes were quantified by qRT-PCR. We found that treatment with MnO2-NPs could induce learning capacity and memory faculty decline and destroy the structure of hippocampal and CP cells in rats. High doses of MnO2-NPs had a more obvious destructive capacity. For transcriptomic analysis, we found that there were significant differences in the numbers and types of differential genes in CP between the low- and high-dose groups compared to the control. Through GO terms and KEGG analysis, high-dose MnO2-NPs significantly affected the expression of transporters, ion channel proteins, and ribosomal proteins. There were 17 common differentially expressed genes. Most of them were transporter and binding genes on the cell membrane, and some of them had kinase activity. Three genes, Brinp, Synpr and Crmp1, were selected for qRT-PCR to confirm their expression differences among the three groups. In conclusion, high-dose MnO2-NPs exposure induced abnormal neurobehaviour, impaired memory function, destroyed the structure of the CP and changed its transcriptome in rats. The most significant DEGs in the CP were within the transport system.

586. Magnetic DNA random access memory with nanopore readouts and exponentially-scaled combinatorial addressing.

Sci Rep

2023 May 25

Lau B(#), Chandak S(#), Roy S

587. Exchange biased surface acoustic wave magnetic field sensors.

Sci Rep

2023 May 25

Schell V, Spetzler E, Wolff N

588. Quantifying generational and geographical inequality of climate change.

Sci Rep

2023 May 25

Hadré E(#), Küpper J(#), Tschirschwitz J(#)

589. Assessing thermal imagery integration into object detection methods on air-based collection platforms.

Sci Rep

2023 May 25

Gallagher JE, Oughton EJ.

590. Targeting fibrotic signaling pathways by EGCG as a therapeutic strategy for uterine fibroids.

Sci Rep

2023 May 25

Islam MS, Parish M, Brennan JT

591. Effects of energy drinks on myogenic differentiation of murine C2C12 myoblasts.

Sci Rep

2023 May 25

Park SY(#), Karantenislis G(#), Rosen HT

592. Unravelling the resilience of the KGK VI population from the Gumelnița site (Romania) through stable isotopes.

Sci Rep

2023 May 25

García-Vázquez A, Bălășescu A, Vasile G

The Gumelnița site belongs to the Kodjadermen-Gumelnița-Karanovo VI (KGK VI) communities (c. 4700-3900 cal BC) and comprises the tell-type settlement and its corresponding cemetery. This paper reconstructs the diet and lifeways of the Chalcolithic people in the northeastern Balkans using archaeological remains found at the Gumelnița site (Romania). A multi-bioarchaeological investigation (archaeobotany, zooarchaeology, anthropology) was conducted on vegetal, animal, and human remains, alongside radiocarbon dating and stable isotope analyses (δ13C, δ15N) of humans (n = 33), mammals (n = 38), reptiles (n = 3), fishes (n = 8), freshwater mussels shells (n = 18), and plants (n = 24). According to the results of δ13C and δ15N values and FRUITS, the inhabitants of Gumelnița had a diet based on crops and using natural resources, such as fish, freshwater molluscs and game. Although domestic fauna was occasionally exploited for meat, it had a role in providing secondary products. Crops were heavily manured, and chaff and other crop waste may have been necessary fodder for cattle and sheep. Dogs and pigs fed on human waste, although the diet of the latter is more similar to that of wild boars. Foxes had a diet close to dogs, which may indicate synanthropic behaviour. Radiocarbon dates were calibrated with the percentage of freshwater resources obtained by FRUITS. As a result, the corrected dates for the freshwater reservoir effect (FRE) have a delay of an average of 147 years. According to our data, this agrarian community developed a subsistence strategy under the pressure of some climatic changes that started after 4300 cal BC, corresponding to KGK VI rapid collapse/decline episode tracked recently (that begins around 4350 cal BC). This matching of our data in the two models (climatic and chrono-demographic) allowed us to capture the economic strategies that led to the resilience of those people more than other contemporary KGK VI communities.

593. Clinical analysis of secondary glaucoma in Central China.

Sci Rep

2023 May 25

Liu Q, Liu C, Cheng W

594. Effect of modified waste introduction methods over short-term and long-term use of onsite sanitation systems.

Sci Rep

2023 May 25

Astete Vasquez L, Mladenov N.

595. A publication-wide association study (PWAS), historical language models to prioritise novel therapeutic drug targets.

Sci Rep

2023 May 24

Narganes-Carlón D, Crowther DJ, Pearson ER.

596. Modeling, optimization and efficient use of MMT K(10) nanoclay for Pb (II) removal using RSM, ANN and GA.

Sci Rep

2023 May 24

Hamidi F, Baghani AN, Kasraee M

597. Large area MoS(2) thin film growth by direct sulfurization.

Sci Rep

2023 May 24

Yang KY, Nguyen HT, Tsao YM

598. Bayesian network analysis of antidepressant treatment trajectories.

Sci Rep

2023 May 24

Turner RJ, Hagoort K, Meijer RJ

599. The ant's weapon improves honey bee learning performance.

Sci Rep

2023 May 24

Bachert A, Scheiner R.

600. Caste-specific expressions and diverse roles of takeout genes in the termite Reticulitermes speratus.

Sci Rep

2023 May 24

Fujiwara K(#), Karasawa A(#), Hanada T

601. Intravenous sildenafil for treatment of early pulmonary hypertension in preterm infants.

Sci Rep

2023 May 24

Schroeder L, Monno P, Strizek B

602. A simple model for pink noise from amplitude modulations.

Sci Rep

2023 May 24

Morikawa M, Nakamichi A.

603. Modified stepping behaviour during outdoor winter walking increases resistance to forward losses of stability.

Sci Rep

2023 May 24

Best AN, Wu AR.

604. Enhancing the upconversion efficiency of NaYF(4):Yb,Er microparticles for infrared vision applications.

Sci Rep

2023 May 24

Khosh Abady K, Dankhar D, Krishnamoorthi A

605. Reanalyzing the genetic history of Kra-Dai speakers from Thailand and new insights into their genetic interactions beyond Mainland Southeast Asia.

Sci Rep

2023 May 24

Changmai P, Phongbunchoo Y, Kočí J

606. Active learning applied to automated physical systems increases the rate of discovery.

Sci Rep

2023 May 24

Shields MD, Gurley K, Catarelli R

607. Second-generation supraglottic airway in laparoscopic donor nephrectomy.

Sci Rep

2023 May 24

Lee JE(#), Kim HY(#), Lee KW

608. APOE ɛ4, but not polygenic Alzheimer's disease risk, is related to longitudinal decrease in hippocampal brain activity in non-demented individuals.

Sci Rep

2023 May 24

Håglin S(#), Koch E(#), Schäfer Hackenhaar F

609. Resting-state EEG delta and alpha power predict response to cognitive behavioral therapy in depression: a Canadian biomarker integration network for depression study.

Sci Rep

2023 May 24

Schwartzmann B, Quilty LC, Dhami P

610. Alpha-lipoic acid attenuates heat stress-induced apoptosis via upregulating the heat shock response in porcine parthenotes.

Sci Rep

2023 May 24

Lee SH, Sun MH, Jiang WJ

611. Surveillance of avian influenza viruses from 2014 to 2018 in South Korea.

Sci Rep

2023 May 24

Españo E, Shim SM, Song EJ

612. Investigation of kinetic, isotherm and adsorption efficacy of thorium by orange peel immobilized on calcium alginate.

Sci Rep

2023 May 24

Khamseh AAG, Ghorbanian SA, Amini Y

613. Early depressive symptoms and disability accrual in Multiple Sclerosis: a UK MS Register study.

Sci Rep

2023 May 24

Jacobs BM(#), Daruwalla C(#), McKeon MO(#)

614. Multimodal imaging of laser-induced choroidal neovascularization in pigmented rabbits.

Sci Rep

2023 May 24

Nguyen VP, Henry J, Zhe J

615. A reconfigurable graphene patch antenna inverse design at terahertz frequencies.

Sci Rep

2023 May 24

Mashayekhi M, Kabiri P, Nooramin AS

616. Topographical influence of electrospun basement membrane mimics on formation of cellular monolayer.

Sci Rep

2023 May 24

Jain P(#), Rimal R(#), Möller M

617. A study on computer vision for facial emotion recognition.

Sci Rep

2023 May 24

Huang ZY, Chiang CC, Chen JH

618. Overall survival prediction models for gynecological endometrioid adenocarcinoma with squamous differentiation (GE-ASqD) using machine-learning algorithms.

Sci Rep

2023 May 24

Liu X(#), Jin S(#), Zi D.

619. Burden of hospital admissions and resulting patient interhospital transports during the 2020/2021 SARS-CoV-2 pandemic in Saxony, Germany.

Sci Rep

2023 May 24

Bender K, Waßer F, Keller Y

Secondary transports of patients from one hospital to another are indicated for medical reasons or to address local constraints in capacity. In particular, interhospital transports of critically ill infectious patients present a logistical challenge and can be key in the effective management of pandemic situations. The state of Saxony in Germany has two characteristics that allow for an extensive evaluation of secondary transports in the pandemic year 2020/2021. First, all secondary transports are centrally coordinated by a single institution. Second, Saxony had the highest SARS-CoV-2 infection rates and the highest COVID-19 associated mortality in Germany. This study evaluates secondary interhospital transports from March 2019 to February 2021 in Saxony with a detailed analysis of transport behaviour during the pandemic phase March 2020 to February 2021. Our analysis includes secondary transports of SARS-CoV-2 patients and compares them to secondary transports of non-infectious patients. In addition, our data show differences in demographics, SARS-CoV-2- incidences, ICU occupancy of COVID-19 patients, and COVID-19 associated mortality in all three regional health clusters in Saxony. In total, 12,282 secondary transports were analysed between March 1st, 2020 and February 28th, 2021, of which 632 were associated with SARS-CoV-2 (5.1%) The total number of secondary transports changed slightly during the study period March 2020 to February 2021. Transport capacities for non-infectious patients were reduced due to in-hospital and out-of-hospital measures and could be used for transport of SARS-CoV-2 patients. Infectious transfers lasted longer despite shorter distance, occurred more frequently on weekends and transported patients were older. Primary transport vehicles were emergency ambulances, transport ambulances and intensive care transport vehicles. Data analysis based on hospital structures showed that secondary transports in correlation to weekly case numbers depend on the hospital type. Maximum care hospitals and specialized hospitals show a maximum of infectious transports approximately 4 weeks after the highest incidences. In contrast, standard care hospitals transfer their patients at the time of highest SARS-CoV-2 case numbers. Two incidence peaks were accompanied by two peaks of increased secondary transport. Our findings show that interhospital transfers of SARS-CoV-2 and non-SARS-CoV-2 patients differ and that different hospital care levels initiated secondary transports at different times during the pandemic.

620. Tracking supercritical geothermal fluid distribution from continuous seismic monitoring.

Sci Rep

2023 May 24

Andajani RD, Tsuji T, Ikeda T

621. Deep learning for multi-class semantic segmentation enables colorectal cancer detection and classification in digital pathology images.

Sci Rep

2023 May 24

Bokhorst JM, Nagtegaal ID, Fraggetta F

622. Flexible and frequency reconfigurable CPW-fed monopole antenna with frequency selective surface for IoT applications.

Sci Rep

2023 May 24

Ibrahim AA, Mohamed HA, Abdelghany MA

623. Prediction of protein subplastid localization and origin with PlastoGram.

Sci Rep

2023 May 24

Sidorczuk K, Gagat P, Kała J

624. Oncostatin M is a regulator of fibroblast growth factor 23 (FGF23) in UMR106 osteoblast-like cells.

Sci Rep

2023 May 24

Münz S, Feger M, Föller M.

625. Convolutional neural networks in the qualitative improvement of sweet potato roots.

Sci Rep

2023 May 24

Clara Gonçalves Fernandes A, Ribeiro Valadares N, Henrique Oliveira Rodrigues C

626. A randomized controlled trial of effects of open-label placebo compared to double-blind placebo and treatment-as-usual on symptoms of allergic rhinitis.

Sci Rep

2023 May 24

Schaefer M, Zimmermann K, Enck P.

627. Coronavirus spike protein-specific antibodies indicate frequent infections and reinfections in infancy and among BNT162b2-vaccinated healthcare workers.

Sci Rep

2023 May 24

Kolehmainen P, Huttunen M, Iakubovskaia A

628. Control variables of serum ferritin concentrations in hospitalized newborn infants: an observational study.

Sci Rep

2023 May 24

Hisano T, Okada J, Tsuda K

629. On nature-inspired design optimization of antenna structures using variable-resolution EM models.

Sci Rep

2023 May 24

Koziel S, Pietrenko-Dabrowska A.

Numerical optimization has been ubiquitous in antenna design for over a decade or so. It is indispensable in handling of multiple geometry/material parameters, performance goals, and constraints. It is also challenging as it incurs significant CPU expenses, especially when the underlying computational model involves full-wave electromagnetic (EM) analysis. In most practical cases, the latter is imperative to ensure evaluation reliability. The numerical challenges are even more pronounced when global search is required, which is most often carried out using nature-inspired algorithms. Population-based procedures are known for their ability to escape from local optima, yet their computational efficiency is poor, which makes them impractical when applied directly to EM models. A common workaround is the utilization of surrogate modeling techniques, typically in the form of iterative prediction-correction schemes, where the accumulated EM simulation data is used to identify the promising regions of the parameter space and to refine the surrogate model predictive power at the same time. Notwithstanding, implementation of surrogate-assisted procedures is often intricate, whereas their efficacy may be hampered by the dimensionality issues and considerable nonlinearity of antenna characteristics. This work investigates the benefits of incorporating variable-resolution EM simulation models into nature-inspired algorithms for optimization of antenna structures, where the model resolution pertains to the level of discretization density of an antenna structure in the full-wave simulation model. The considered framework utilizes EM simulation models which share the same physical background and are selected from a continuous spectrum of allowable resolutions. The early stages of the search process are carried out with the use of the lowest fidelity model, which is subsequently automatically increased to finally reach the high-fidelity antenna representation (i.e., considered as sufficiently accurate for design purposes). Numerical validation is executed using several antenna structures of distinct types of characteristics, and a particle swarm optimizer as the optimization engine. The results demonstrate that appropriate resolution adjustment profiles permit considerable computational savings (reaching up to eighty percent in comparison to high-fidelity-based optimization) without noticeable degradation of the search process reliability. The most appealing features of the presented approach-apart from its computational efficiency-are straightforward implementation and versatility.

630. Unraveling lignin degradation in fibre cement via multidimensional fluorometry.

Sci Rep

2023 May 24

Hoque M, Kamal S, Raghunath S

631. The effect of Lavandula Coronopifolia essential oil on the biophysical properties of desensitization and deactivation gating currents in ionotropic receptors.

Sci Rep

2023 May 24

Qneibi M, Jaradat N, Al-Maharik N

632. Enhancement growth, water use efficiency and economic benefit for maize by drip irrigation in Northwest China.

Sci Rep

2023 May 24

Liu M, Liang F, Li Q

633. Efficiency of botulinum toxin injection into the arm on postural balance and gait after stroke.

Sci Rep

2023 May 24

Lee J, Park JE, Kang BH

634. Clinical outcomes of a new four-haptic hydrophobic presbyopia-correcting intraocular lens.

Sci Rep

2023 May 24

Whang WJ, Kim TI, Tchah H

635. A case-based reasoning system for neonatal survival and LOS prediction in neonatal intensive care units: a development and validation study.

Sci Rep

2023 May 24

Kermani F, Zarkesh MR, Vaziri M

636. Comparison of silicone double-lumen tube and polyvinyl chloride single-lumen tube in fiberoptic tracheal intubation on a difficult airway model: a randomized controlled non-inferiority trial.

Sci Rep

2023 May 24

Kang S, Chae YJ, Kim DH

637. Memory compensation strategies in everyday life: similarities and differences between younger and older adults.

Sci Rep

2023 May 24

Radnan MJ, Nicholson R, Brookman R

638. Yawning and scratching contagion in wild spider monkeys (Ateles geoffroyi).

Sci Rep

2023 May 24

Valdivieso-Cortadella S, Bernardi-Gómez C, Aureli F

639. Entropy generation and flow characteristics of Powell Eyring fluid under effects of time sale and viscosities parameters.

Sci Rep

2023 May 24

Hassan M, Ahsan M, Usman

640. Asphericity derived from [(18)F]FDG PET as a new prognostic parameter in cervical cancer patients.

Sci Rep

2023 May 24

Cegla P, Hofheinz F, Burchardt E

641. Association between visceral obesity, metformin use, and recurrence risk in early-stage colorectal cancer.

Sci Rep

2023 May 24

Vedire YR(#), Mukherjee S(#), Dondapati S

642. Long-term use of denosumab and its association with skeletal-related events and osteonecrosis of the jaw.

Sci Rep

2023 May 24

Fu PA(#), Shen CY(#), Yang SR

643. A multi-site study of the relationship between photoperiod and ovulation rate using Natural Cycles data.

Sci Rep

2023 May 24

Shanmugam D, Espinosa M, Gassen J

644. Reducing mitochondrial ribosomal gene expression does not alter metabolic health or lifespan in mice.

Sci Rep

2023 May 24

Reid K(#), Daniels EG(#), Vasam G

645. Complex implementation factors demonstrated when evaluating cost-effectiveness and monitoring racial disparities associated with [(18)F]DCFPyL PET/CT in prostate cancer men.

Sci Rep

2023 May 23

Subramanian K, Martinez J, Huicochea Castellanos S

646. Spermidine improves angiogenic capacity of senescent endothelial cells, and enhances ischemia-induced neovascularization in aged mice.

Sci Rep

2023 May 23

Ueno D, Ikeda K, Yamazaki E

647. Identification of novel interacts partners of ADAR1 enzyme mediating the oncogenic process in aggressive breast cancer.

Sci Rep

2023 May 23

Binothman N, Aljadani M, Alghanem B

648. Sting and p53 DNA repair pathways are compromised in Alzheimer's disease.

Sci Rep

2023 May 23

Nelson TJ, Xu Y.

649. Eight-year tillage in black soil, effects on soil aggregates, and carbon and nitrogen stock.

Sci Rep

2023 May 23

Wang L, Qi S, Gao W

650. Novel in vivo endometriotic models associated eutopic endometrium by implanting menstrual blood-derived stromal cells from patients with endometriosis.

Sci Rep

2023 May 23

Zhang Y(#), He T(#), Lin T

The eutopic endometrium provides novel insights into endometriotic pathophysiology and treatment. However, no in vivo models currently available are suitable for eutopic endometrium in endometriosis. In this study, we present new endometriotic in vivo models associated with eutopic endometrium using menstrual blood-derived stromal cells (MenSCs). First, we isolated endometriotic MenSCs (E-MenSCs) and healthy MenSCs (H-MenSCs) from the menstrual blood of patients with endometriosis (n = 6) and healthy volunteers (n = 6). Then, we identified MenSCs' endometrial stromal cell properties using adipogenic and osteogenic differentiation. A cell counting kit-8 and wound healing assay were used to compare the proliferation and migration capability between E-MenSCs and H-MenSCs. Seventy female nude mice were used to prepare endometriotic models related to eutopic endometrium by implanting E-MenSCs relying on three approaches, including surgical implantation using scaffolds seeded with MenSCs, and subcutaneous injection of MenSCs in the abdomen and the back (n = 10). H-MenSCs or scaffolds only were implanted in control groups (n = 10). One month after the surgical implantation and 1 week after the subcutaneous injection, we evaluated modeling by hematoxylin-eosin (H&E) and immunofluorescent staining of human leukocyte antigen α (HLAA). Fibroblast morphology, lipid droplets, and calcium nodules in E-MenSCs and H-MenSCs identified their endometrial stromal cell properties. We noticed that the proliferation and migration of E-MenSCs were considerably enhanced compared to H-MenSCs (P < 0.05). E-MenSCs implanted in nude mice formed ectopic lesions using three approaches (n = 10; lesions formation rate: 90%, 115%, and 80%; average volumes: 123.60, 27.37, and 29.56 mm3), while H-MenSCs in the nude mice shaped nothing at the implantation sites. Endometrial glands, stroma, and HLAA expression in these lesions further verified the success and applicability of the proposed endometriotic modeling. Findings provide in vitro and in vivo models and paired controls associated with eutopic endometrium in women with endometriosis using E-MenSCs and H-MenSCs. The approach of subcutaneous injection of MenSCs in the abdomen is highlighted due to non-invasive, simple, and safe steps, a short modeling period (1 week), and an excellent modeling success rate (115%), which could improve the repeats and success of endometriotic nude mice model and shorten the modeling period. These novel models could nearly intimate human eutopic endometrial mesenchymal stromal cells in the progress of endometriosis, opening a new path for disease pathology and treatment.

651. Respiratory eukaryotic virome expansion and bacteriophage deficiency characterize childhood asthma.

Sci Rep

2023 May 23

Megremis S, Constantinides B, Xepapadaki P

652. PhaeoEpiView: an epigenome browser of the newly assembled genome of the model diatom Phaeodactylum tricornutum.

Sci Rep

2023 May 23

Wu Y(#), Chaumier T(#), Manirakiza E

653. Thermal inspection for viscous dissipation slip flow of hybrid nanofluid (TiO(2)-Al(2)O(3)/C(2)H(6)O(2)) using cylinder, platelet and blade shape features.

Sci Rep

2023 May 23

Yang H, Hayat U, Shaiq S

654. Long-term risk of major adverse cardiovascular events following ischemic stroke or TIA.

Sci Rep

2023 May 23

Carlsson A, Irewall AL, Graipe A

655. Extensive cytokine biomarker analysis in serum of Guillain-Barré syndrome patients.

Sci Rep

2023 May 23

Li X, Yang L, Wang G

656. Single-cell transcriptional profiling of hearts during cardiac hypertrophy reveals the role of MAMs in cardiomyocyte subtype switching.

Sci Rep

2023 May 23

Luan Y(#), Guo G(#), Luan Y

657. Evaluation of airway involvement and treatment in patients with relapsing polychondritis.

Sci Rep

2023 May 23

Handa H, Ooka S, Shimizu J

658. Effects of 5G-modulated 3.5 GHz radiofrequency field exposures on HSF1, RAS, ERK, and PML activation in live fibroblasts and keratinocytes cells.

Sci Rep

2023 May 23

Joushomme A, Orlacchio R, Patrignoni L

659. Bivariate logistic regression model diagnostics applied to analysis of outlier cancer patients with comorbid diabetes and hypertension in Malawi.

Sci Rep

2023 May 23

Kaombe TM, Banda JC, Hamuza GA

660. Elevated risk of cervical cancer in elderly women with incident ulcerative colitis in South Korea.

Sci Rep

2023 May 23

Kim J(#), Jo H(#), Ha MC

661. Adaptive changes to saccade amplitude and target localization do not require pre-saccadic target visibility.

Sci Rep

2023 May 23

Heins F, Masselink J, Scherer JN

662. Therapeutic effects of axitinib, an anti-angiogenic tyrosine kinase inhibitor, on interstitial cystitis.

Sci Rep

2023 May 23

Shin JH(#), Ryu CM(#), Yu HY

663. Live birth rate following a failed first in vitro fertilization cycle with no embryos for transfer.

Sci Rep

2023 May 23

Dong X, Xue X.

664. Solar ultraviolet light collector for germicidal irradiation on the moon.

Sci Rep

2023 May 23

Lombini M, Schreiber L, Albertini R

Prolonged human-crewed missions on the Moon are foreseen as a gateway for Mars and asteroid colonisation in the next decades. Health risks related to long-time permanence in space have been partially investigated. Hazards due to airborne biological contaminants represent a relevant problem in space missions. A possible way to perform pathogens' inactivation is by employing the shortest wavelength range of Solar ultraviolet radiation, the so-called germicidal range. On Earth, it is totally absorbed by the atmosphere and does not reach the surface. In space, such Ultraviolet solar component is present and effective germicidal irradiation for airborne pathogens' inactivation can be achieved inside habitable outposts through a combination of highly reflective internal coating and optimised geometry of the air ducts. The Solar Ultraviolet Light Collector for Germicidal Irradiation on the Moon is a project whose aim is to collect Ultraviolet solar radiation and use it as a source to disinfect the re-circulating air of the human outposts. The most favourable positions where to place these collectors are over the peaks at the Moon's poles, which have the peculiarity of being exposed to solar radiation most of the time. On August 2022, NASA communicated to have identified 13 candidate landing regions near the lunar South Pole for Artemis missions. Another advantage of the Moon is its low inclination to the ecliptic, which maintains the Sun's apparent altitude inside a reduced angular range. For this reason, Ultraviolet solar radiation can be collected through a simplified Sun's tracking collector or even a static collector and used to disinfect the recycled air. Fluid-dynamic and optical simulations have been performed to support the proposed idea. The expected inactivation rates for some airborne pathogens, either common or found on the International Space Station, are reported and compared with the proposed device efficiency. The results show that it is possible to use Ultraviolet solar radiation directly for air disinfection inside the lunar outposts and deliver a healthy living environment to the astronauts.

665. Biocontrol potential of native isolates of Beauveria bassiana against cotton leafworm Spodoptera litura (Fabricius).

Sci Rep

2023 May 23

Islam SMN, Chowdhury MZH, Mim MF

666. The organellar genomes of Pellidae (Marchantiophyta): the evidence of cryptic speciation, conflicting phylogenies and extraordinary reduction of mitogenomes in simple thalloid liverwort lineage.

Sci Rep

2023 May 23

Paukszto Ł, Górski P, Krawczyk K

667. Evaluating the effect of gamma rays on Zamiifolia (Zamioculcas zamiifolia) plant in vitro and genetic diversity of the resulting genotypes using the ISSR marker.

Sci Rep

2023 May 23

Beyramizadeh E, Arminian A, Fazeli A.

Zamiifolia (Zamioculcas sp.) is a perennial plant in the Araceae family and one of the new apartment plants in the world. In this study, in order to increase the effectiveness of the breeding program, tissue culture technique and explants of leaf parts were used. The results indicated that 2,4-D (1 mg/l) and BA (2 mg/l) hormones affected positively and significantly callus formation and simultaneous application of NAA and BA (both in 0.5 mg/l) caused the best results regarding seedling production and number, leaves, complete tubers, and root in tissue culture of Zaamifolia. In the study, three cultivars of Zamiifolia (green, black and Dutch) and 12 genotypes resulted from callus formation stage, irradiated with different gamma rays (0 to 175 Gy, with LD50 as 68 Gy) were selected and the presence of genetic diversity was investigated using 22 ISSR primers. Applying ISSR marker showed that the highest amount of PIC values related to the F19(0.47) and F20(0.38) primers, which persuasively isolated the studied genotypes. Moreover, the highest efficiency was detected for AK66 marker based on the MI parameter. The PCA and clustering categorization via UPGMA methodology based on molecular information and Dice index, differentiated the genotypes into 6 groups. Genotypes 1(callus), 2(100 Gy) and 3(cultivar from Holland) created separated groups. The 4th group included 6(callus), 8(0 Gy), 9(75 Gy), 11(90 Gy), 12(100 Gy) and 13(120 Gy) genotypes appearing as the largest group. The 5th group included 7(160 Gy), 10(80 Gy), 14(140 Gy) and 15(Zanziber gem black) genotypes. The last group included 4(mather plant) and 5(callus) genotypes. In this context, genotypes 1, 5, and 6 had probably somaclonal variation. Moreover, genotypes that received doses of 100 and 120 Gy, had a medium diversity. There is a high possibility of introducing a cultivar with a low dose and high genetic diversity in the whole group. Genotype 7 in this classification, received the highest dose of 160 Gy. In this population, the Dutch variety, was used as a new variety. As a result, the ISSR marker could correctly group the genotypes. This is an interesting finding, and it could be hypothesized that the ISSR marker could correctly differentiate Zaamifolia genotypes and probably other ornamental plants under the effect of gamma rays mutagenesis in order to achieve novel variants.

668. Bacteriophage-loaded functional nanofibers for treatment of P. aeruginosa and S. aureus wound infections.

Sci Rep

2023 May 23

Kielholz T, Rohde F, Jung N

669. A cyclic behavioral modeling aspect to understand the effects of vaccination and treatment on epidemic transmission dynamics.

Sci Rep

2023 May 23

Zobayer A, Ullah MS, Ariful Kabir KM.

670. Predictors of postoperative pain six months after breast surgery.

Sci Rep

2023 May 23

J Ghadimi D, Looha MA, Akbari ME

671. Exploring the effects of habituation and scent in first-person 360-degree videos on consumption behavior.

Sci Rep

2023 May 23

Li BJ, Lee HM.

672. Mechanism modeling and application of Salvia miltiorrhiza percolation process.

Sci Rep

2023 May 23

Wang W(#), Ding F(#), Qu H

673. Emergence of community-associated methicillin-resistant Staphylococcus aureus ΨUSA300 among Japanese people with HIV, resulted from stepwise mutations in 2010s.

Sci Rep

2023 May 23

Shinohara K, Uehara Y, Teruya K

674. Renin-angiotensin system inhibitors mitigate radiation pneumonitis by activating ACE2-angiotensin-(1-7) axis via NF-κB/MAPK pathway.

Sci Rep

2023 May 23

Cong C(#), Niu S(#), Jiang Y(#)

675. Changes in total cholesterol level and cardiovascular disease risk among type 2 diabetes patients.

Sci Rep

2023 May 23

Khil J(#), Kim SM(#), Chang J

676. An automated image-based workflow for detecting megabenthic fauna in optical images with examples from the Clarion-Clipperton Zone.

Sci Rep

2023 May 23

Mbani B, Buck V, Greinert J.

Recent advances in optical underwater imaging technologies enable the acquisition of huge numbers of high-resolution seafloor images during scientific expeditions. While these images contain valuable information for non-invasive monitoring of megabenthic fauna, flora and the marine ecosystem, traditional labor-intensive manual approaches for analyzing them are neither feasible nor scalable. Therefore, machine learning has been proposed as a solution, but training the respective models still requires substantial manual annotation. Here, we present an automated image-based workflow for Megabenthic Fauna Detection with Faster R-CNN (FaunD-Fast). The workflow significantly reduces the required annotation effort by automating the detection of anomalous superpixels, which are regions in underwater images that have unusual properties relative to the background seafloor. The bounding box coordinates of the detected anomalous superpixels are proposed as a set of weak annotations, which are then assigned semantic morphotype labels and used to train a Faster R-CNN object detection model. We applied this workflow to example underwater images recorded during cruise SO268 to the German and Belgian contract areas for Manganese-nodule exploration, within the Clarion-Clipperton Zone (CCZ). A performance assessment of our FaunD-Fast model showed a mean average precision of 78.1% at an intersection-over-union threshold of 0.5, which is on a par with competing models that use costly-to-acquire annotations. In more detail, the analysis of the megafauna detection results revealed that ophiuroids and xenophyophores were among the most abundant morphotypes, accounting for 62% of all the detections within the surveyed area. Investigating the regional differences between the two contract areas further revealed that both megafaunal abundance and diversity was higher in the shallower German area, which might be explainable by the higher food availability in form of sinking organic material that decreases from east-to-west across the CCZ. Since these findings are consistent with studies based on conventional image-based methods, we conclude that our automated workflow significantly reduces the required human effort, while still providing accurate estimates of megafaunal abundance and their spatial distribution. The workflow is thus useful for a quick but objective generation of baseline information to enable monitoring of remote benthic ecosystems.

677. Full-duplex multi-user MIMO communication systems performance optimization using leakage-based precoding.

Sci Rep

2023 May 23

Teklu MB, Choi DY, Meng WX.

678. Semantic modeling of cell damage prediction: a machine learning approach at human-level performance in dermatology.

Sci Rep

2023 May 23

Wagner P, Springenberg M, Kröger M

679. UQCRFS1 serves as a prognostic biomarker and promotes the progression of ovarian cancer.

Sci Rep

2023 May 23

Sun Q(#), Li J(#), Dong H

680. Using machine learning methods to predict electric vehicles penetration in the automotive market.

Sci Rep

2023 May 23

Afandizadeh S, Sharifi D, Kalantari N

681. High heat flux reduction to materials using current filaments.

Sci Rep

2023 May 23

Le T, Suzuki Y, Hasegawa H

682. 2D tunable all-solid-state random laser in the visible.

Sci Rep

2023 May 23

Kumar B, Homri R, Sebbah P.

683. Establishment of a novel model of endometriosis-associated ovarian cancer by transplanting uterine tissue from Arid1a/Pten knockout mice.

Sci Rep

2023 May 23

Ono M, Miyamoto T, Asaka R

684. AZD5438 a GSK-3a/b and CDK inhibitor is antiapoptotic modulates mitochondrial activity and protects human neurons from mitochondrial toxins.

Sci Rep

2023 May 23

Shi G, Scott H, Azhar NIFM

685. High throughput biochemical profiling, and functional potential analysis for valorization of grape peduncles.

Sci Rep

2023 May 23

Akbar A, Gul Z, Hussain N

686. Sexual dimorphisms in serum calcium and phosphate concentrations in the Rotterdam Study.

Sci Rep

2023 May 23

Bosman A(#), Koek WNH(#), Campos-Obando N

Sex differences in serum phosphate and calcium have been reported but the exact nature and underlying regulatory mechanisms remain unclear. We aimed to compare calcium and phosphate concentrations between sexes, and explore potential covariates to elucidate underlying mechanisms of sex differences in a prospective, population-based cohort study. Pooled data of subjects > 45 years from three independent cohorts of the Rotterdam Study (RS) were used: RS-I-3 (n = 3623), RS-II-1 (n = 2394), RS-III-1 (n = 3241), with separate analyses from an additional time point of the first cohort RS-I-1 (n = 2688). Compared to men, women had significantly higher total serum calcium and phosphate concentrations which was not explained by BMI, kidney function nor smoking. Adjustment for serum estradiol diminished sex differences in serum calcium while adjustment for serum testosterone diminished sex differences in serum phosphate. Adjustment for vitamin D and alkaline phosphatase did not change the association between sex and calcium or phosphate in RS-I-1. In the sex-combined group, both serum calcium and phosphate decreased with age with a significant interaction for sex differences for serum calcium but not phosphate. In sex-stratified analyses, serum estradiol but not testosterone was inversely associated with serum calcium in both sexes. Serum estradiol was inversely associated with serum phosphate in both sexes to a similar degree, while serum testosterone was inversely associated with serum phosphate in both sexes with an apparent stronger effect in men than in women. Premenopausal women had lower serum phosphate compared to postmenopausal women. Serum testosterone was inversely associated with serum phosphate in postmenopausal women only. In conclusion, women > 45 years have higher serum calcium and phosphate concentrations compared to men of similar age, not explained by vitamin D or alkaline phosphatase concentrations. Serum estradiol but not testosterone was inversely associated with serum calcium while serum testosterone was inversely associated with serum phosphate in both sexes. Serum testosterone may in part explain sex differences in serum phosphate while estradiol could partly explain sex differences in serum calcium.

687. A quadratic time-dependent quantum harmonic oscillator.

Sci Rep

2023 May 23

Onah FE, García Herrera E(#), Ruelas-Galván JA(#)

688. Zinc chloride is effective as an antibiotic in biofilm prevention following septoplasty.

Sci Rep

2023 May 23

Noach N, Lavy E, Reifen R

689. The association between dietary acrylamide intake and the risk of type 2 diabetes incidence in the Tehran lipid and glucose study.

Sci Rep

2023 May 22

Hosseini-Esfahani F, Beheshti N, Nematollahi A

690. Investigating various metal contacts for p-type delafossite α-CuGaO(2) to fabricate ultraviolet photodetector.

Sci Rep

2023 May 22

Abrari M, Ghanaatshoar M, Malvajerdi SS

691. Pandemic elevates sensitivity to moral disgust but not pathogen disgust.

Sci Rep

2023 May 22

Schwambergová D, Kaňková Š, Třebická Fialová J

692. Solid acid-catalyzed one-step synthesis of oleacein from oleuropein.

Sci Rep

2023 May 22

Shimamoto Y, Fujitani T, Uchiage E

693. Intra-group competition and social dynamics regarding dispersal and maturation in wild Javan gibbon (Hylobates moloch).

Sci Rep

2023 May 22

Choi A, Yi Y, Mardiastuti A

694. A novel approach to topological network analysis for the identification of metrics and signatures in non-small cell lung cancer.

Sci Rep

2023 May 22

Wu I, Wang X.

695. A state-of-the-art methodology for high-throughput in silico vaccine discovery against protozoan parasites and exemplified with discovered candidates for Toxoplasma gondii.

Sci Rep

2023 May 22

Goodswen SJ, Kennedy PJ, Ellis JT.

696. Impact of d-states on transition metal impurity diffusion in TiN.

Sci Rep

2023 May 22

Nayak GK, Holec D, Zelený M.

697. Robust multiple-scroll dynamics in memristive-based generator system.

Sci Rep

2023 May 22

Adelakun AO, Odusote YA.

698. The potency of bacteriophages isolated from chicken intestine and beef tribe to control biofilm-forming bacteria, Bacillus subtilis.

Sci Rep

2023 May 22

Wardani AK, Buana EOGHN, Sutrisno A.

699. Disinfection of SARS-CoV-2 by UV-LED 267 nm: comparing different variants.

Sci Rep

2023 May 22

Atari N, Mamane H, Silberbush A

700. Spatiotemporal characteristics of cortical activities of REM sleep behavior disorder revealed by explainable machine learning using 3D convolutional neural network.

Sci Rep

2023 May 22

Kim H, Seo P, Byun JI

701. Fertilization altered co-occurrence patterns and microbial assembly process of ammonia-oxidizing microorganisms.

Sci Rep

2023 May 22

Ma M(#), Zhao Y(#), Jiang X

702. Depression and anxiety during and after episodes of COVID-19 in the community.

Sci Rep

2023 May 22

Alacevich C, Thalmann I, Nicodemo C

703. Model and simulator of inlet air flow in grinding installation with electromagnetic mill.

Sci Rep

2023 May 22

Krauze O.

704. Impact of different ventilation conditions on tobacco smoke-associated particulate matter emissions in a car cabin using the TAPaC platform.

Sci Rep

2023 May 22

Pitten L, Brüggmann D, Dröge J

Despite antagonizing attempts from the tobacco industry, passive inhalation of tobacco smoke is known to be cancerogenic and toxic to human health for decades. Nonetheless, millions of non-smoking adults and children are still victims of second-hand smoke. Accumulation of particulate matter (PM) in confined spaces such as the car are particularly harmful due to high concentrations. We here aimed to analyze the specific effects of ventilation conditions in the setting of a car. By the use of the measuring platform TAPaC (tobacco-associated particulate matter emissions inside a car cabin), 3R4F reference cigarettes, Marlboro red, and Marlboro gold were smoked in a car interior with a volume of 3.709 m3. Seven different ventilation conditions (C1-C7) were analyzed. Under C1, all windows were closed. Under C2-C7, the car ventilation was turned on power level 2/4 with the air directed towards the windshield. Only the passenger side window was opened, where an outer placed fan could create an airstream speed of 15.9-17.4 km/h at one meter distance to simulate a driving car. C2: Window 10 cm opened. C3: Window 10 cm opened with the fan turned on. C4: Window half-opened. C5: Window half-opened with the fan turned on. C6: Window fully opened. C7: Window fully opened with the fan turned on. Cigarettes were remotely smoked by an automatic environmental tobacco smoke emitter and a cigarette smoking device. Depending on the ventilation condition the cigarettes emitted different mean PM concentrations after 10 min under condition C1 (PM10: 1272-1697 µg/m3, PM2.5: 1253-1659 µg/m3, PM1: 964-1263 µg/m3) under C2, C4, and C6 (PM10: 68.7-196.2 µg/m3, PM2.5: 68.2-194.7 µg/m3, PM1: 66.1-183.8 µg/m3) C3, C5, and C7 (PM10: 73.7-139 µg/m3, PM2.5: 72-137.9 µg/m3, PM1:68.9-131.9 µg/m3). Vehicle ventilation is insufficient to protect passengers from toxic second-hand smoke completely. Brand-specific variations of tobacco ingredients and mixtures markedly influence PM emissions under ventilation conditions. The most efficient ventilation mode to reduce PM exposure was achieved by opening the passenger´s window 10 cm and turning the onboard ventilation on power level 2/4. In-vehicle smoking should be banned to preserve innocent risk groups (e.g., children) from harm.

705. Pattern and predictors of death from aluminum and zinc phosphide poisoning using multi-kernel optimized relevance vector machine.

Sci Rep

2023 May 22

Abdelghafar S, Farrag TA, Zanaty A

706. GPU accelerated digital twins of the human heart open new routes for cardiovascular research.

Sci Rep

2023 May 22

Viola F, Del Corso G, De Paulis R

707. Association between serum leptin concentrations and homeostasis model assessment-insulin resistance of 2.5 and higher in normal weight Japanese women.

Sci Rep

2023 May 22

Minato-Inokawa S, Hayashida Y, Honda M

708. An intelligent fuzzy-particle swarm optimization supervisory-based control of robot manipulator for industrial welding applications.

Sci Rep

2023 May 22

Sathish Kumar A, Naveen S, Vijayakumar R

709. Algorithm selection for protein-ligand docking: strategies and analysis on ACE.

Sci Rep

2023 May 22

Chen T, Shu X, Zhou H

The present study investigates the use of algorithm selection for automatically choosing an algorithm for any given protein-ligand docking task. In drug discovery and design process, conceptualizing protein-ligand binding is a major problem. Targeting this problem through computational methods is beneficial in order to substantially reduce the resource and time requirements for the overall drug development process. One way of addressing protein-ligand docking is to model it as a search and optimization problem. There have been a variety of algorithmic solutions in this respect. However, there is no ultimate algorithm that can efficiently tackle this problem, both in terms of protein-ligand docking quality and speed. This argument motivates devising new algorithms, tailored to the particular protein-ligand docking scenarios. To this end, this paper reports a machine learning-based approach for improved and robust docking performance. The proposed set-up is fully automated, operating without any expert opinion or involvement both on the problem and algorithm aspects. As a case study, an empirical analysis was performed on a well-known protein, Human Angiotensin-Converting Enzyme (ACE), with 1428 ligands. For general applicability, AutoDock 4.2 was used as the docking platform. The candidate algorithms are also taken from AutoDock 4.2. Twenty-eight distinctly configured Lamarckian-Genetic Algorithm (LGA) are chosen to build an algorithm set. ALORS which is a recommender system-based algorithm selection system was preferred for automating the selection from those LGA variants on a per-instance basis. For realizing this selection automation, molecular descriptors and substructure fingerprints were employed as the features characterizing each target protein-ligand docking instance. The computational results revealed that algorithm selection outperforms all those candidate algorithms. Further assessment is reported on the algorithms space, discussing the contributions of LGA's parameters. As it pertains to protein-ligand docking, the contributions of the aforementioned features are examined, which shed light on the critical features affecting the docking performance.

710. Inferring origin-destination distribution of agent transfer in a complex network using deep gated recurrent units.

Sci Rep

2023 May 22

Saw VL, Vismara L, Suryadi

711. Noninvasive ventilation in patients with acute hypoxemic respiratory failure: a systematic review and meta-analysis of randomized controlled trials.

Sci Rep

2023 May 22

Aswanetmanee P, Limsuwat C, Maneechotesuwan K

712. Social deprivation in maternal mouthbrooders Tropheus sp. "Caramba" (Teleostei: Cichlidae) decreases the success rate of reproduction and survival rate of fish fry.

Sci Rep

2023 May 22

Novák J, Frynta D, Nováková D

713. Intestine and brain TLR-4 modulation following N-acetyl-cysteine treatment in NEC rodent model.

Sci Rep

2023 May 22

Beloosesky R, Gutzeit O, Ginsberg Y

714. Determination of optimum intensity and duration of exercise based on the immune system response using a machine-learning model.

Sci Rep

2023 May 22

Asadi S, Tartibian B, Moni MA.

One of the important concerns in the field of exercise immunology is determining the appropriate intensity and duration of exercise to prevent suppression of the immune system. Adopting a reliable approach to predict the number of white blood cells (WBCs) during exercise can help to identify the appropriate intensity and duration. Therefore, this study was designed to predict leukocyte levels during exercise with the application of a machine-learning model. We used a random forest (RF) model to predict the number of lymphocytes (LYMPH), neutrophils (NEU), monocytes (MON), eosinophils, basophils, and WBC. Intensity and duration of exercise, WBCs values before exercise training, body mass index (BMI), and maximal aerobic capacity (VO2 max) were used as inputs and WBCs values after exercise training were assessed as outputs of the RF model. In this study, the data was collected from 200 eligible people and K-fold cross-validation was used to train and test the model. Finally, model efficiency was assessed using standard statistics (root mean square error (RMSE), mean absolute error (MAE), relative absolute error (RAE), root relative square error (RRSE), coefficient of determination (R2), and Nash-Sutcliffe efficiency coefficient (NSE)). Our findings revealed that the RF model performed well for predicting the number of WBC with RMSE = 0.94, MAE = 0.76, RAE = 48.54, RRSE = 48.17, NSE = 0.76, and R2 = 0.77. Furthermore, the results showed that intensity and duration of exercise are more effective parameters than BMI and VO2 max to predict the number of LYMPH, NEU, MON, and WBC during exercise. Totally, this study developed a novel approach based on the RF model using the relevant and accessible variables to predict WBCs during exercise. The proposed method can be applied as a promising and cost-effective tool for determining the correct intensity and duration of exercise in healthy people according to the body's immune system response.

715. Morel-Lavallee lesions and number of surgeries for associated injuries predict surgical site infection risk following pelvic ring injury osteosynthesis.

Sci Rep

2023 May 22

Lai CY, Lai PJ, Tseng IC

716. Assessing coastline recession for adaptation planning: sea level rise versus storm erosion.

Sci Rep

2023 May 22

Ranasinghe R, Callaghan DP, Li F

The Sixth Assessment report (AR6) of the Intergovernmental Panel on Climate Change (IPCC) states with high confidence that most sandy coasts around the world will experience an increase in coastal erosion over the twenty-first century. An increase in long term coastal erosion (coastline recession) along sandy coasts can translate into massive socio-economic impacts, unless appropriate adaptation measures are implemented in the next few decades. To adequately inform adaptation measures, it is necessary to have a good understanding of the relative importance of the physical processes driving coastline recession, as well as of linkages between consideration (or not) of certain processes and the level of risk tolerance; understandings that are hitherto lacking. Here, we apply the multi-scale Probabilistic Coastline Recession (PCR) model to two end-member sandy coastal types (swell dominated and storm dominated), to investigate where and when coastline recession projections are dominated by the differential contributions from Sea Level Rise (SLR) and storm erosion. Results show that SLR substantially increases the projected end-century recession at both types of coasts and that projected changes in the wave climate have only a marginal impact. An analysis of the Process Dominance Ratio (PDR), introduced here, shows that the dominance of storm erosion over SLR (and vice versa) on total recession by 2100 depends on both the type of the beach and the risk tolerance levels. For moderately risk-averse decisions (i.e. decisions accounting only for high exceedance probability recessions and hence do not account for very high amounts of potential recession-for example, the placement of temporary summer beach cabins), additional erosion due to SLR can be considered as the dominant driver of end-century recession at both types of beaches. However, for more risk-averse decisions that would typically account for higher potential recession (i.e. lower exceedance probability recessions), such as the placement of coastal infrastructure, multi-storey apartment buildings etc., storm erosion becomes the dominant process. The results of this study provide new insights on which physical processes need to be considered when and where in terms of numerical modelling efforts needed for supporting different management decisions, potentially enabling more streamlined and comprehensive assessments of the efficacy of coastal adaptation measures.

717. Elevation in white blood cell count and development of hyper LDL cholesterolemia.

Sci Rep

2023 May 22

Okutsu S, Kato Y, Takeoka H

718. Simulation of nitrate pollution and vulnerability of groundwater resources using MODFLOW and DRASTIC models.

Sci Rep

2023 May 22

Eslamian S, Harooni Y, Sabzevari Y.

719. The retinal neurovascular coupling is impaired in men with vasculogenic erectile dysfunction.

Sci Rep

2023 May 22

Borrelli E(#), Quarta A(#), Pozzi E

720. Uncovering the impact of AM fungi on wheat nutrient uptake, ion homeostasis, oxidative stress, and antioxidant defense under salinity stress.

Sci Rep

2023 May 22

Huang S, Gill S, Ramzan M

721. Deletion of endothelial leptin receptors in mice promotes diet-induced obesity.

Sci Rep

2023 May 22

Gogiraju R, Witzler C, Shahneh F

722. Myoelectric activity during electromagnetic resistance alone and in combination with variable resistance or eccentric overload.

Sci Rep

2023 May 22

Zambrano H, Torres X, Coleman M

The purpose of this study was to compare the effects of electromagnetic resistance alone, as well as in combination with variable resistance or accentuated eccentric methods, with traditional dynamic constant external resistance exercise on myoelectric activity during elbow flexion. The study employed a within-participant randomized, cross-over design whereby 16 young, resistance-trained male and female volunteers performed elbow flexion exercise under each of the following conditions: using a dumbbell (DB); using a commercial electromagnetic resistance device (ELECTRO); variable resistance (VR) using a setting on the device that attempts to match the level of resistance to the human strength curve, and; eccentric overload (EO) using a setting on the device that increases the load by 50% on the eccentric portion of each repetition. Surface electromyography (sEMG) was obtained for the biceps brachii, brachioradialis and anterior deltoid on each of the conditions. Participants performed the conditions at their predetermined 10 repetition maximum. " The order of performance for the conditions was counterbalanced, with trials separated by a 10-min recovery period. The sEMG was synced to a motion capture system to assess sEMG amplitude at elbow joint angles of 30°, 50°, 70°, 90°, 110°, with amplitude normalized to the maximal activation. The anterior deltoid showed the largest differences in amplitude between conditions, where median estimates indicated greater concentric sEMG amplitude (~ 7-10%) with EO, ELECTRO and VR compared with DB. Concentric biceps brachii sEMG amplitude was similar between conditions. In contrast, results indicated a greater eccentric amplitude with DB compared to ELECTRO and VR, but unlikely to exceed a 5% difference. Data indicated a greater concentric and eccentric brachioradialis sEMG amplitude with DB compared to all other conditions, but differences were unlikely to exceed 5%. The electromagnetic device tended to produce greater amplitudes in the anterior deltoid, while DB tended to produce greater amplitudes in the brachioradialis; amplitude for the biceps brachii was relatively similar between conditions. Overall, any observed differences were relatively modest, equating to magnitudes of ~ 5% and not likely greater than 10%. These differences would seem to be of minimal practical significance.

723. Generation of equatorial plasma bubble after the 2022 Tonga volcanic eruption.

Sci Rep

2023 May 22

Shinbori A, Sori T, Otsuka Y

724. Nicotinamide N-methyltransferase (NNMT) regulates the glucocorticoid signaling pathway during the early phase of adipogenesis.

Sci Rep

2023 May 22

Roberti A, Tejedor JR, Díaz-Moreno I

725. Seg2Link: an efficient and versatile solution for semi-automatic cell segmentation in 3D image stacks.

Sci Rep

2023 May 22

Wen C, Matsumoto M, Sawada M

726. Diagnostic value of two-time point [(68)Ga]Ga-PSMA-11 PET/CT in the primary staging of untreated prostate cancer.

Sci Rep

2023 May 22

Weitzer F, Pernthaler B, Plhak E

The emerging PET tracer [68Ga]Ga-PSMA-11 has been established for staging in prostate cancer (PCa). Aim was to determine the value of early static imaging in two-phase PET/CT. 100 men with newly diagnosed histopathologically confirmed untreated PCa who underwent [68Ga]Ga-PSMA-11 PET/CT from January 2017 to October 2019 were included. The two-phase imaging protocol consisted of an early static scan of the pelvis (6 min p.i.) and a late total-body scan (60 min p.i). Associations of semi-quantitative parameters derived via volumes of interest (VOI) with Gleason grade group and PSA were investigated. In 94/100 patients (94%) the primary tumor was detected in both phases. In 29/100 patients (29%) metastases were detected at a median PSA level of 32.2 ng/ml (0.41-503 ng/ml). In 71/100 patients (71%) without metastasis a median PSA level of 10.1 ng/ml (0.57-103 ng/ml) was observed (p = < 0.001). Primary tumors demonstrated a median standard uptake value maximum (SUVmax) of 8.2 (3.1-45.3) in early phase versus 12.2 (3.1-73.4) in late phase and a median standard uptake value mean (SUVmean) of 4.2 (1.6-24.1) in early phase versus 5.8 (1.6-39.9) in late phase, significantly increasing over time (p = < 0.001). Higher SUVmax and SUVmean were associated with higher Gleason grade group (p = 0.004 and p = 0.003, respectively) and higher PSA levels (p = < 0.001). In 13/100 patients the semi-quantitative parameters including SUVmax were declining in the late phase compared to early phase. Two-phase [68Ga]Ga-PSMA-11 PET/CT demonstrates a high detection rate for primary tumor of untreated PCa of 94% and improves diagnostic accuracy. Higher PSA levels and Gleason grade group are associated with higher semi-quantitative parameters in the primary tumor. Early imaging provides additional information in a small sub-group with declining semi-quantitative parameters in the late phase.

727. Hybrid quantum-classical machine learning for generative chemistry and drug design.

Sci Rep

2023 May 22

Gircha AI, Boev AS, Avchaciov K

728. DELMEP: a deep learning algorithm for automated annotation of motor evoked potential latencies.

Sci Rep

2023 May 22

Milardovich D(#), Souza VH(#), Zubarev I

729. LncRNA FAS-AS1 upregulated by its genetic variation rs6586163 promotes cell apoptosis in nasopharyngeal carcinoma through regulating mitochondria function and Fas splicing.

Sci Rep

2023 May 22

Guo Z, Li Z, Zhang M

730. Correlation between airborne pollen data and the risk of tick-borne encephalitis in northern Italy.

Sci Rep

2023 May 22

Marini G(#), Tagliapietra V(#), Cristofolini F

Tick-borne encephalitis (TBE) is caused by a flavivirus that infects animals including humans. In Europe, the TBE virus circulates enzootically in natural foci among ticks and rodent hosts. The abundance of ticks depends on the abundance of rodent hosts, which in turn depends on the availability of food resources, such as tree seeds. Trees can exhibit large inter-annual fluctuations in seed production (masting), which influences the abundance of rodents the following year, and the abundance of nymphal ticks two years later. Thus, the biology of this system predicts a 2-year time lag between masting and the incidence of tick-borne diseases such as TBE. As airborne pollen abundance is related to masting, we investigated whether inter-annual variation in pollen load could be directly correlated with inter-annual variation in the incidence of TBE in human populations with a 2-year time lag. We focused our study on the province of Trento (northern Italy), where 206 TBE cases were notified between 1992 and 2020. We tested the relationship between TBE incidence and pollen load collected from 1989 to 2020 for 7 different tree species common in our study area. Through univariate analysis we found that the pollen quantities recorded two years prior for two tree species, hop-hornbeam (Ostrya carpinifolia) and downy oak (Quercus pubescens), were positively correlated with TBE emergence (R2 = 0.2) while a multivariate model with both tree species better explained the variation in annual TBE incidence (R2 = 0.34). To the best of our knowledge, this is the first attempt at quantifying the correlation between pollen quantities and the incidence of TBE in human populations. As pollen loads are collected by widespread aerobiological networks using standardized procedures, our study could be easily replicated to test their potential as early warning system for TBE and other tick-borne diseases.

731. A preliminary study of the use of MinION sequencing to specifically detect Shiga toxin-producing Escherichia coli in culture swipes containing multiple serovars of this species.

Sci Rep

2023 May 22

Tunsjø HS, Ullmann IF, Charnock C.

732. Cerium and samarium blocked antioxidant enzymes in wheat plants.

Sci Rep

2023 May 22

Haghighi AK, Rezayian M, Niknam V

733. Parasympathetic autonomic dysfunction is more often evidenced than sympathetic autonomic dysfunction in fluctuating and polymorphic symptoms of "long-COVID" patients.

Sci Rep

2023 May 22

Zanin A(#), Amah G(#), Chakroun S

734. The effect of lifestyle on the mortality associated with respiratory diseases in the general population.

Sci Rep

2023 May 22

Murano H, Inoue S, Sato K

735. A quantitative meta-analysis comparing cell models in perfused organ on a chip with static cell cultures.

Sci Rep

2023 May 22

Dufva M.

736. Feeding recycled food waste improved feed efficiency in laying hens from 24 to 43 weeks of age.

Sci Rep

2023 May 22

Dao HT, Sharma NK, Swick RA

737. In vitro studies of factors affecting debridement of dental implants by tricalcium phosphate powder abrasive treatment.

Sci Rep

2023 May 22

Chen IC, Su CY, Tu JJ

738. Pain and the emotional brain: pain-related cortical processes are better reflected by affective evaluation than by cognitive evaluation.

Sci Rep

2023 May 22

Stankewitz A, Mayr A, Irving S

739. Experimental and numerical investigation of polymer pore-clogging in micromodels.

Sci Rep

2023 May 22

Sugar A, Serag M, Buttner U

Polymers have been used effectively in the Oil & Gas Industry for a variety of field applications, such as enhanced oil recovery (EOR), well conformance, mobility control, and others. Polymer intermolecular interactions with the porous rock, in particular, formation clogging and the associated alterations to permeability, is a common problem in the industry. In this work, fluorescent polymers and single-molecule imaging are presented for the first time to assess the dynamic interaction and transport behavior of polymer molecules utilizing a microfluidic device. Pore-scale simulations are performed to replicate the experimental observations. The microfluidic chip, also known as a "Reservoir-on-a-Chip" functions as a 2D surrogate to evaluate the flow processes that take place at the pore-scale. The pore-throat sizes of an oil-bearing reservoir rock, which range from 2 to 10 nm, are taken into consideration while designing the microfluidic chip. Using soft lithography, we created the micromodel from polydimethylsiloxane (PDMS). The conventional use of tracers to monitor polymers has a restriction due to the tendency of polymer and tracer molecules to segregate. For the first time, we develop a novel microscopy method to observe the dynamic behavior of polymer pore-clogging and unclogging processes. We provide direct dynamic observations of polymer molecules during their transport within the aqueous phase and their clustering and accumulations. Pore-scale simulations were carried out to simulate the phenomena using a finite-element simulation tool. The simulations revealed a decline in flow conductivity over time within the flow channels that experienced polymer accumulation and retention, which is consistent with the experimental observation of polymer retention. The performed single-phase flow simulations allowed us to assess the flow behavior of the tagged polymer molecules within the aqueous phase. Additionally, both experimental observation and numerical simulations are used to evaluate the retention mechanisms that emerge during flow and how they affect apparent permeability. This work provides new insights to assessing the mechanisms of polymer retention in porous media.

740. A blood and bronchoalveolar lavage protein signature of rapid FEV(1) decline in smoking-associated COPD.

Sci Rep

2023 May 22

DiLillo KM, Norman KC, Freeman CM

741. Flax fiber based semicarbazide biosorbent for removal of Cr(VI) and Alizarin Red S dye from wastewater.

Sci Rep

2023 May 22

Akl MA, El-Zeny AS, Hashem MA

742. Adding tactile feedback increases avatar ownership and makes virtual reality more effective at reducing pain in a randomized crossover study.

Sci Rep

2023 May 22

Hoffman HG, Fontenot MR, Garcia-Palacios A

743. Effects of four disease-controlling agents (chlorothalonil, CuCl(2), harpin, and melatonin) on postharvest jujube fruit quality.

Sci Rep

2023 May 22

Tian S(#), Chen Y(#), Wang Q(#)

744. Novel genetically engineered mouse models for clear cell renal cell carcinoma.

Sci Rep

2023 May 22

van der Mijn JC(#), Laursen KB(#), Fu L

Genetically engineered mouse models (GEMMs) are important immunocompetent models for research into the roles of individual genes in cancer and the development of novel therapies. Here we use inducible CRISPR-Cas9 systems to develop two GEMMs which aim to model the extensive chromosome p3 deletion frequently observed in clear cell renal cell carcinoma (ccRCC). We cloned paired guide RNAs targeting early exons of Bap1, Pbrm1, and Setd2 in a construct containing a Cas9D10A (nickase, hSpCsn1n) driven by tetracycline (tet)-responsive elements (TRE3G) to develop our first GEMM. The founder mouse was crossed with two previously established transgenic lines, one carrying the tet-transactivator (tTA, Tet-Off) and one with a triple-mutant stabilized HIF1A-M3 (TRAnsgenic Cancer of the Kidney, TRACK), both driven by a truncated, proximal tubule-specific γ-glutamyltransferase 1 (ggt or γGT) promoter, to create triple-transgenic animals. Our results indicate that this model (BPS-TA) induces low numbers of somatic mutations in Bap1 and Pbrm1 (but not in Setd2), known tumor suppressor genes in human ccRCC. These mutations, largely restricted to kidneys and testis, induced no detectable tissue transformation in a cohort of 13 month old mice (N = 10). To gain insights into the low frequencies of insertions and deletions (indels) in BPS-TA mice we analyzed wild type (WT, N = 7) and BPS-TA (N = 4) kidneys by RNAseq. This showed activation of both DNA damage and immune response, suggesting activation of tumor suppressive mechanisms in response to genome editing. We then modified our approach by generating a second model in which a ggt-driven, cre-regulated Cas9WT(hSpCsn1) was employed to introduce Bap1, Pbrm1, and Setd2 genome edits in the TRACK line (BPS-Cre). The BPS-TA and BPS-Cre lines are both tightly controlled in a spatiotemporal manner with doxycycline (dox) and tamoxifen (tam), respectively. In addition, whereas the BPS-TA line relies on paired guide RNAs (gRNAs), the BPS-Cre line requires only single gRNAs for gene perturbation. In the BPS-Cre we identified increased Pbrm1 gene-editing frequencies compared to the BPS-TA model. Whereas we did not detect Setd2 edits in the BPS-TA kidneys, we found extensive editing of Setd2 in the BPS-Cre model. Bap1 editing efficiencies were comparable between the two models. Although no gross malignancies were observed in our study, this is the first reported GEMM which models the extensive chromosome 3p deletion frequently observed in kidney cancer patients. Further studies are required (1) to model more extensive 3p deletions, e.g. impacting additional genes, and (2) to increase the cellular resolution, e.g. by employing single-cell RNAseq to ascertain the effects of specific combinatorial gene inactivation.

745. The first-trimester serum high-temperature requirement protease A4 and uterine artery Doppler for the prediction of preeclampsia.

Sci Rep

2023 May 22

Siricharoenthai P, Phupong V.

746. Diverse electrical responses in a network of fractional-order conductance-based excitable Morris-Lecar systems.

Sci Rep

2023 May 22

Sharma SK(#), Mondal A(#), Kaslik E

The diverse excitabilities of cells often produce various spiking-bursting oscillations that are found in the neural system. We establish the ability of a fractional-order excitable neuron model with Caputo's fractional derivative to analyze the effects of its dynamics on the spike train features observed in our results. The significance of this generalization relies on a theoretical framework of the model in which memory and hereditary properties are considered. Employing the fractional exponent, we first provide information about the variations in electrical activities. We deal with the 2D class I and class II excitable Morris-Lecar (M-L) neuron models that show the alternation of spiking and bursting features including MMOs & MMBOs of an uncoupled fractional-order neuron. We then extend the study with the 3D slow-fast M-L model in the fractional domain. The considered approach establishes a way to describe various characteristics similarities between fractional-order and classical integer-order dynamics. Using the stability and bifurcation analysis, we discuss different parameter spaces where the quiescent state emerges in uncoupled neurons. We show the characteristics consistent with the analytical results. Next, the Erdös-Rényi network of desynchronized mixed neurons (oscillatory and excitable) is constructed that is coupled through membrane voltage. It can generate complex firing activities where quiescent neurons start to fire. Furthermore, we have shown that increasing coupling can create cluster synchronization, and eventually it can enable the network to fire in unison. Based on cluster synchronization, we develop a reduced-order model which can capture the activities of the entire network. Our results reveal that the effect of fractional-order depends on the synaptic connectivity and the memory trace of the system. Additionally, the dynamics captures spike frequency adaptation and spike latency that occur over multiple timescales as the effects of fractional derivative, which has been observed in neural computation.

747. The effect of exercise on cerebral blood flow and executive function among young adults: a double-blinded randomized controlled trial.

Sci Rep

2023 May 22

Liu J(#), Min L(#), Liu R(#)

Studies have demonstrated that exercise benefits executive function. However, it remains unclear which type of exercise is optimal for preserving executive function among young adults and the cerebral blood flow (CBF) mechanisms that underlie exercise-induced cognitive benefits. Therefore, this study aims to compare the intervention effects of high-intensity interval training (HIIT) and moderate-intensity continuous training (MICT) on executive function and the CBF mechanism. This was a double-blinded, randomized, controlled trial study conducted between October 2020 and January 2021 (ClinicalTrials.gov identifier: NCT04830059). Ninety-three healthy young adults (25.23 ± 2.18 years old; 49.82% male) were randomized into the HIIT (N = 33), MICT (N = 32), and control (N = 28) groups. Participants in exercise groups were guided to perform 40 min of HIIT and MICT three times a week for 12 weeks, while the control group received health education for the same period. The primary outcomes, changes in executive function assessed by the trail-making test (TMT), and CBF measured by transcranial Doppler flow analyzer (EMS-9WA), were evaluated before and after the interventions. The time taken to complete the TMT task improved significantly in the MICT group compared to the control group [β = -10.175, 95%, confidence interval (CI) = -20.320, -0.031]. Additionally, the MICT group showed significant improvements in the pulsatility index (PI) (β = 0.120, 95% CI = 0.018, 0.222), resistance index (RI) (β = 0.043, 95% CI = 0.005, 0.082), and peak-systolic/end-diastolic velocity (S/D) (β = 0.277, 95% CI = 0.048, 0.507) of CBF compared to the control group. The time taken to complete the TMT was associated with the velocity of peak-systolic (F = 5.414, P = 0.022), PI (F = 4.973, P = 0.012), and RI (F = 5.845, P = 0.006). Furthermore, the accuracy of TMT was associated with PI (F = 4.797, P = 0.036), RI (F = 5.394, P = 0.024), and S/D (F = 4.312, P = 0.05) of CBF. A 12-week MICT intervention improved CBF and executive function more effectively than HIIT among young adults. Furthermore, the findings suggest that CBF was one of the potential mechanisms underlying the cognitive benefits of exercise in young people. These results provide practical evidence supporting the promotion of regular exercise to maintain executive function and improve brain health.

748. Adaptive fuzzy sliding mode control of an actuator powered by two opposing pneumatic artificial muscles.

Sci Rep

2023 May 22

Duong MD(#), Pham QT, Vu TC

749. Residual deformation of coal gangue subgrade filler under multi-vibration cyclic loading.

Sci Rep

2023 May 21

Tang X, Wan W, Zhang Z

750. Application of artificial intelligence in green building concept for energy auditing using drone technology under different environmental conditions.

Sci Rep

2023 May 21

Khan O, Parvez M, Alansari M

751. Cilia-associated wound repair mediated by IFT88 in retinal pigment epithelium.

Sci Rep

2023 May 21

Ning K, Bhuckory MB, Lo CH

752. Testing the speed of "spooky action at a distance" in a tabletop experiment.

Sci Rep

2023 May 21

Santamaria Amato L, Pallotti DK, Siciliani de Cumis M

753. Application of neural networks and neuro-fuzzy models in construction scheduling.

Sci Rep

2023 May 21

Obianyo JI, Udeala RC, Alaneme GU.

Construction scheduling is a complex process that involves a large number of variables, making it difficult to develop accurate and efficient schedules. Traditional scheduling techniques rely on manual analysis and intuition, which are prone to errors and often fail to account for all the variables involved. This results in project delays, cost overruns, and poor project performance. Artificial intelligence models have shown promise in improving construction scheduling accuracy by incorporating historical data, site-specific conditions, and other variables that traditional scheduling methods may not consider. In this research study, application of soft-computing techniques to evaluate construction schedule and control of project activities in order to achieve optimal performance in execution of building projects were carried out. Artificial neural network and neuro-fuzzy models were developed using data extracted from a residential two-storey reinforced concrete framed-structure construction schedule and project execution documents. The evaluation of project performance indicators in earned value analysis from 0 to 100% progress at 5% increment with a total of seventeen tasks were carried out using Microsoft Project software and data obtained from the computation were utilized for model development. Using input-output and curve-fitting (nftool) function in MATLAB, a 6-10-1 two-layer feed-forward network with tansig activation-function (AF) for the hidden neurons and linear AF output neurons was generated with Levenberg-Marquardt (Trainlm) training algorithm. Similarly, with the aid of ANFIS toolbox in MATLAB software, the training, testing and validation of the ANFIS model were carried out using hybrid optimization learning algorithm at 100 epochs and the Gaussian-membership-function (gaussmf). Loss-function parameters namely MAE, RMSE and R-values were taken as the performance evaluation criteria of the developed models. The generated statistical results indicates no significant difference between model-results and experimental values with MAE, RMSE, R2 of 1.9815, 2.256 and 99.9% respectively for ANFIS-model and MAE, RMSE, R2 of 2.146, 2.4095 and 99.998% respectively for the ANN-model. The model performance indicated that the ANFIS-model outclassed the ANN-model with their results satisfactory to deal with complex relationships between the model variables to produce accurate target response. The findings from this research study will improve the accuracy of construction scheduling, resulting in improved project performance and reduced costs.

754. Comparative transcriptome analysis of Veratrum maackii and Veratrum nigrum reveals multiple candidate genes involved in steroidal alkaloid biosynthesis.

Sci Rep

2023 May 21

Wang D(#), Yu Z(#), Guan M(#)

755. High sensitivity and wide response range artificial synapse based on polyimide with embedded graphene quantum dots.

Sci Rep

2023 May 20

Kou L, Ye N, Waheed A

756. Epigenome-wide association study of diabetic chronic kidney disease progression in the Korean population: the KNOW-CKD study.

Sci Rep

2023 May 20

Sung HY(#), Lee S(#), Han M(#)

757. Fast decomposed method to devise broadband polarization-conversion metasurface.

Sci Rep

2023 May 20

Xiao X, Lu J, Alzaabi F

758. Computational methods of EEG signals analysis for Alzheimer's disease classification.

Sci Rep

2023 May 20

Vicchietti ML, Ramos FM, Betting LE

759. Heterologous vaccination utilizing viral vector and protein platforms confers complete protection against SFTSV.

Sci Rep

2023 May 20

Kim JY(#), Jeon K(#), Hong JJ(#)

760. Socio-ecological impact of monogenetic volcanism in the La Garrotxa Volcanic Field (NE Iberia).

Sci Rep

2023 May 20

Revelles J, Martí Molist J, Burjachs F

761. Reproduction of bacterial chemotaxis by a non-living self-propelled object.

Sci Rep

2023 May 20

Hamano Y, Ikeda K, Odagiri K

Taxic behavior as a response to an external stimulus is a fundamental function of living organisms. Some bacteria successfully implement chemotaxis without directly controlling the direction of movement. They periodically alternate between run and tumble, i.e., straight movement and change in direction, respectively. They tune their running period depending on the concentration gradient of attractants around them. Consequently, they respond to a gentle concentration gradient stochastically, which is called "bacterial chemotaxis." In this study, such a stochastic response was reproduced by a non-living self-propelled object. We used a phenanthroline disk floating on an aqueous solution of Fe[Formula: see text]. The disk spontaneously alternated between rapid motion and rest, similar to the run-and-tumble motion of bacteria. The movement direction of the disk was isotropic independent of the concentration gradient. However, the existing probability of the self-propelled object was higher at the low-concentration region, where the run length was longer. To explain the mechanism underlying this phenomenon, we proposed a simple mathematical model that considers random walkers whose run length depends on the local concentration and direction of movement against the gradient. Our model adopts deterministic functions to reproduce the both effects, which is instead of stochastic tuning the period of operation used in the previous reports. This allows us to analyze the proposed model mathematically, which indicated that our model reproduces both positive and negative chemotaxis depending on the competition between the local concentration effect and it's gradient effect. Owing to the newly introduced directional bias, the experimental observations were reproduced numerically and analytically. The results indicate that the directional bias response to the concentration gradient is an essential parameter for determining bacterial chemotaxis. This rule might be universal for the stochastic response of self-propelled particles in living and non-living systems.

762. Glycerol induced paraspinal muscle degeneration leads to hyper-kyphotic spinal deformity in wild-type mice.

Sci Rep

2023 May 20

Noonan AM, Buliung E, Briar KJ

763. Identifying high snakebite risk area under climate change for community education and antivenom distribution.

Sci Rep

2023 May 20

Yousefi M, Yousefkhani SH, Grünig M

764. Thermomagnetic properties and its effects on Fisher entropy with Schioberg plus Manning-Rosen potential (SPMRP) using Nikiforov-Uvarov functional analysis (NUFA) and supersymmetric quantum mechanics (SUSYQM) methods.

Sci Rep

2023 May 20

Okon IB, Onate CA, Horchani R

765. Identification of a mycobacterial hydrazidase, an isoniazid-hydrolyzing enzyme.

Sci Rep

2023 May 20

Sakiyama A, Saren C, Kaneko Y

766. Autistic traits shape neuronal oscillations during emotion perception under attentional load modulation.

Sci Rep

2023 May 20

Duville MM, Ibarra-Zarate DI, Alonso-Valerdi LM.

767. Anxiety, concerns and emotion regulation in individuals with Williams syndrome and Down syndrome during the COVID-19 outbreak: a global study.

Sci Rep

2023 May 20

Sideropoulos V, Sokhn N, Palikara O

768. Immobilization of Cr(3+), Cd(2+), and Pb(2+) added to calcareous soil amended with composted agro-industrial residues.

Sci Rep

2023 May 20

Khedr M, Emran M, Gispert M

The bioavailability of trace metals in soils poses a major threat to the environment, especially with massive mineral fertilizers added to increase plant yield. A plot experiment was conducted for the effectiveness evaluation of compost and vermicompost, recycled from agro-industrial wastes, in immobilizing chromium, cadmium, and lead added to calcareous soil (artificially contaminated). Moreover, immobilization efficiency was compared to the natural occurrence of these metals in the soil without metal addition (uncontaminated soil). In both soils, amendments and mineral fertilizers were applied at three different levels alone and combined to each other. The experimental design was arranged in factorial complete randomized blocks using contamination, organic and mineral fertilizer levels, and their combination as categorical factors. The distribution of metal fractions and their bioavailability in soils and bioaccumulation in wheat grains were evaluated. Soil alkalinity, the contents of soil organic carbon and nitrogen, available phosphorus, and soil micronutrients were significantly improved under vermicompost and compost compared to mineral fertilizer and control. Vermicompost was more effective than compost in reducing metals bioavailability in contaminated soils by increasing the immobilized organic fractions, but it regressed when combined with mineral fertilizers. The bioavailability of the naturally occurring metal levels in uncontaminated soil did not change significantly compared to contaminated soil. Likewise, wheat yield, plant biomass, and nutrient enrichment in wheat grains improved due to enhanced soil nutrient availability. These composted agro-industrial residues, by-products from food industries, can be classified as environmentally-friendly soil amendments for their great potential to enrich soil nutrients, reduce mineral fertilizer addition, enhance plant growth, and stabilize Cr, Cd, and Pb in contaminated calcareous soils under wheat plants.

769. Plasma metabolomics reveals major changes in carbohydrate, lipid, and protein metabolism of abruptly weaned beef calves.

Sci Rep

2023 May 20

González LA, Carvalho JGS, Kuinchtner BC

770. Physical distancing versus testing with self-isolation for controlling an emerging epidemic.

Sci Rep

2023 May 20

Newbold SC, Ashworth M, Finnoff D

771. Identifying signatures of positive selection in human populations from North Africa.

Sci Rep

2023 May 20

Caro-Consuegra R, Lucas-Sánchez M, Comas D

772. Study on soil erosion and its driving factors from the perspective of landscape in Xiushui watershed, China.

Sci Rep

2023 May 20

Wen L, Peng Y, Zhou Y

Soil erosion (SE) is one of the most serious disasters in the world, which directly damage the productivity of the land and affect human well-being. How to effectively mitigate soil erosion is a challenge faced by all countries in the world. In this study, soil erosion was quantitatively assessed base on the RULSE model in an ecologically fragile area [Xiushui watershed (XSW)], and the effects of three major categories of factors (land use/cover change, landscape fragmentation and climate) on soil erosion were investigated using correlation analysis and structural equation model. The results indicated that there was no continuous increase or decrease trend on the SE of XSW with impact of rainfall, the mean values of SE were 2205.27 t/ha, 3414.25 t/ha and 3319.44 t/ha from 2000 to 2020 and the hot areas of SE were mainly distributed around the Xiushui river channel, respectively. The expansion of urbanization (the area of impervious increased from 113.12 to 252.57 km2) aggravated landscape fragmentation, and the landscape fragmented area had some overlap with the hot zone of SE. Additionally, the LUCC factor dominated by NDVI, landscape fragmentation factor and climate factor dominated by rainfall had a directly driving effect on SE, where the path coefficient of landscape fragmentation was 0.61 (P < 0.01), respectively. We also found that except increasing forest area, improving forest quality (NDVI, canopy closure, structure) deserved emphasized in SE management, and the effect of landscape fragmentation on SE also should not be ignored. Moreover, soil erosion assessment at large scales over long time periods tends to underestimate the driving force of rainfall on SE, and it is a great challenge to evaluate the effect of extreme rainfall on soil erosion at short time scales in a downscale manner. This research provides insights for ecological sustainable management and soil erosion protection policies.

773. Early postoperative laboratory parameters are predictive of initial treatment failure in acute septic arthritis of the knee and shoulder joint.

Sci Rep

2023 May 20

Straub J, Lingitz MT, Apprich S

774. Clinical significance of distal femur morphology in a healthy Mongolian youth population.

Sci Rep

2023 May 20

Wang B, Zhang G, Pu R

775. The prevalence and determinant of overweight and obesity among residents aged 40-69 years in high-risk regions for upper gastrointestinal cancer in southeast China.

Sci Rep

2023 May 20

Feng X, Zhu J(#), Hua Z

Being overweight or obese is one of the public health concerns worldwide, and its prevalence is gradually increasing. Obesity has been proven to be associated with some cancers, including upper gastrointestinal cancer (UGC). However, studies on the prevalence of obesity among residents of areas at high risk of UGC in China are minimal. The aim of this study is to assess the prevalence of obesity and its influencing factors among people aged 40-69 years (high-risk population) in high-risk areas for UGC in Jiangsu Province, southeast China. This cross-sectional study involved 45,036 subjects aged 40-69 years identified in the Rural Early Diagnosis and Treatment of UGC Project database in Jiangsu Province from 2017 to 2021. Differences in prevalence across gender and age were assessed using the Chi-square test. Using a multinomial logistic regression model, we examined independent risk factors for overweight/obesity and their gender and age differences. The prevalence of overweight, obesity, and overweight/obesity varied based on the standards used: Chinese standard (42.1%, 11.9%, and 54.0%) and WHO standard (34.7%, 4.7%, and 39.4%), respectively. Being overweight was more common in men than women, while obesity was more common in women than men. Age of 50-59 years, married, household size of 7-9, drinking, soy products, pickled food, and hot food intake were positively associated with overweight/obesity. Females, 60-69 years, higher education level, household size of 4-6, annual family income of more than 60,000 CNY, smoking, and fresh fruit intake were negatively associated with overweight/obesity. Stratified analysis showed that the effects of age, education and meat, egg and dairy products on overweight/obesity were different across gender. The impact of fresh fruit and vegetables on overweight/obesity was also heterogeneous between the younger (40-59 years) and older (60-69 years) groups. In conclusion, the prevalence of overweight and obesity is high among adults aged 40-69 years from high-risk areas for UGC of Jiangsu Province, southeast China. Independent influencing factors of being overweight/obese included gender, age, marital status, education, household size, annual family income, smoking, drinking, fresh fruit, soy products, pickled food and hot food intake, and may vary by gender and age. Screening-based interventions should be considered to control obesity levels among screened participants. Besides, heterogeneity of influencing factors across subgroups could be focused on to improve intervention effectiveness.

776. Comparison of pneumonia incidence between long-acting muscarinic antagonist and inhaled corticosteroid plus long-acting beta agonist in patients with COPD.

Sci Rep

2023 May 20

Lee EG, Kim Y, Hwang YI

777. Investigating immune profile by CyTOF in individuals with long-standing type 1 diabetes.

Sci Rep

2023 May 20

Larsson H, Albinsson Högberg S, Lind M

778. Motional consensus of self-propelled particles.

Sci Rep

2023 May 20

Qian JX, Wang J, Lu YQ.

779. Ball-milling synthesized Bi(2)VO(5.5) for piezo-photocatalytic assessment.

Sci Rep

2023 May 20

Kumar M, Vaish R, Kebaili I

780. Remotely sensed terrestrial open water evaporation.

Sci Rep

2023 May 20

Fisher JB, Dohlen MB, Halverson GH

Terrestrial open water evaporation is difficult to measure both in situ and remotely yet is critical for understanding changes in reservoirs, lakes, and inland seas from human management and climatically altered hydrological cycling. Multiple satellite missions and data systems (e.g., ECOSTRESS, OpenET) now operationally produce evapotranspiration (ET), but the open water evaporation data produced over millions of water bodies are algorithmically produced differently than the main ET data and are often overlooked in evaluation. Here, we evaluated the open water evaporation algorithm, AquaSEBS, used by ECOSTRESS and OpenET against 19 in situ open water evaporation sites from around the world using MODIS and Landsat data, making this one of the largest open water evaporation validations to date. Overall, our remotely sensed open water evaporation retrieval captured some variability and magnitude in the in situ data when controlling for high wind events (instantaneous: r2 = 0.71; bias = 13% of mean; RMSE = 38% of mean). Much of the instantaneous uncertainty was due to high wind events (u > mean daily 7.5 m·s-1) when the open water evaporation process shifts from radiatively-controlled to atmospherically-controlled; not accounting for high wind events decreases instantaneous accuracy significantly (r2 = 0.47; bias = 36% of mean; RMSE = 62% of mean). However, this sensitivity minimizes with temporal integration (e.g., daily RMSE = 1.2-1.5 mm·day-1). To benchmark AquaSEBS, we ran a suite of 11 machine learning models, but found that they did not significantly improve on the process-based formulation of AquaSEBS suggesting that the remaining error is from a combination of the in situ evaporation measurements, forcing data, and/or scaling mismatch; the machine learning models were able to predict error well in and of itself (r2 = 0.74). Our results provide confidence in the remotely sensed open water evaporation data, though not without uncertainty, and a foundation by which current and future missions may build such operational data.

781. Antimicrobial resistance gene lack in tick-borne pathogenic bacteria.

Sci Rep

2023 May 20

Papp M, Tóth AG, Valcz G

782. Novel design of inspiratory flow generation and gas mixing for critical care ventilators suitable for rapid production and mass casualty incidents.

Sci Rep

2023 May 2

Roubik K, Ort V, Horakova L

783. The public's preferred level of involvement in local policy-making.

Sci Rep

2023 May 2

Haesevoets T, Roets A, Van Severen R

784. Integrated optical beam steering device using switchable nanoantennas and a reflective metalens.

Sci Rep

2023 May 2

Ghaffari V, Yousefi L.

785. Physaria fendleri FAD3-1 overexpression increases ɑ-linolenic acid content in Camelina sativa seeds.

Sci Rep

2023 May 2

Park ME, Choi HA, Kim HU.

786. A probabilistic approach to lifetime design of offshore platforms.

Sci Rep

2023 May 2

Hajinezhadian M, Behnam B.

787. Social exclusion in people with diabetes: cross-sectional and longitudinal results from the German Ageing Survey (DEAS).

Sci Rep

2023 May 2

Prell T, Stegmann S, Schönenberg A.

788. Ordinary citizens are more severe towards verbal than nonverbal hate-motivated incidents with identical consequences.

Sci Rep

2023 May 2

Zapata J, Deroy O.

789. STAGEs: A web-based tool that integrates data visualization and pathway enrichment analysis for gene expression studies.

Sci Rep

2023 May 2

Koh CWT, Ooi JSG, Ong EZ

790. Implementing a velocity-based approach to resistance training: the reproducibility and sensitivity of different velocity monitoring technologies.

Sci Rep

2023 May 2

Jukic I, King A, Sousa CA

791. Reinforcement learning for patient-specific optimal stenting of intracranial aneurysms.

Sci Rep

2023 May 2

Hachem E, Meliga P, Goetz A

792. Impact of nanoparticles on vegetable oil as a cutting fluid with fractional ramped analysis.

Sci Rep

2023 May 2

Hasin F, Ahmad Z, Ali F

793. Changes in body perception following virtual object manipulation are accompanied by changes of the internal reference scale.

Sci Rep

2023 May 2

Kirsch W, Kunde W.

794. Effect of vaginal probiotics containing Lactobacillus casei rhamnosus (Lcr regenerans) on vaginal dysbiotic microbiota and pregnancy outcome, prospective, randomized study.

Sci Rep

2023 May 2

Petricevic L, Rosicky I, Kiss H

795. Spatial timing of circulating seasonal influenza A and B viruses in China from 2014 to 2018.

Sci Rep

2023 May 2

Zhu AQ, Li ZJ, Zhang HJ.

796. Modeling the antidepressant treatment response to transcranial magnetic stimulation using an exponential decay function.

Sci Rep

2023 May 2

Berlow YA, Zandvakili A, Brennan MC

797. Measure cross-sectoral structural similarities from financial networks.

Sci Rep

2023 May 2

Boersma M, Wolsink J, Sourabh S

798. Non-invasive imaging of interstitial fluid transport parameters in solid tumors in vivo.

Sci Rep

2023 May 2

Majumder S, Islam MT, Righetti R.

In this paper, new and non-invasive imaging methods to assess interstitial fluid transport parameters in tumors in vivo are developed, analyzed and experimentally validated. These parameters include extracellular volume fraction (EVF), interstitial fluid volume fraction (IFVF) and interstitial hydraulic conductivity (IHC), and they are known to have a critical role in cancer progression and drug delivery effectiveness. EVF is defined as the volume of extracellular matrix per unit volume of the tumor, while IFVF refers to the volume of interstitial fluid per unit bulk volume of the tumor. There are currently no established imaging methods to assess interstitial fluid transport parameters in cancers in vivo. We develop and test new theoretical models and imaging techniques to assess fluid transport parameters in cancers using non-invasive ultrasound methods. EVF is estimated via the composite/mixture theory with the tumor being modeled as a biphasic (cellular phase and extracellular phase) composite material. IFVF is estimated by modeling the tumor as a biphasic poroelastic material with fully saturated solid phase. Finally, IHC is estimated from IFVF using the well-known Kozeny-Carman method inspired by soil mechanics theory. The proposed methods are tested using both controlled experiments and in vivo experiments on cancers. The controlled experiments were performed on tissue mimic polyacrylamide samples and validated using scanning electron microscopy (SEM). In vivo applicability of the proposed methods was demonstrated using a breast cancer model implanted in mice. Based on the controlled experimental validation, the proposed methods can estimate interstitial fluid transport parameters with an error below 10% with respect to benchmark SEM data. In vivo results demonstrate that EVF, IFVF and IHC increase in untreated tumors whereas these parameters are observed to decrease over time in treated tumors. The proposed non-invasive imaging methods may provide new and cost-effective diagnostic and prognostic tools to assess clinically relevant fluid transport parameters in cancers in vivo.

799. Improved grey water footprint model based on uncertainty analysis.

Sci Rep

2023 May 2

Li J, Lin M, Feng Y.

800. Learning curve of i-gel insertion in novices using a cumulative sum analysis.

Sci Rep

2023 May 2

Nakanishi T, Sakamoto S, Yoshimura M

801. Modified lumbo-pelvic exercise to alleviate mild stress urinary incontinence in middle-aged females.

Sci Rep

2023 May 2

Wang Y(#), Liu L(#), Chen Q

802. Enabling personalized perioperative risk prediction by using a machine-learning model based on preoperative data.

Sci Rep

2023 May 2

Graeßner M, Jungwirth B, Frank E

803. Evaluation of FRAX in patients with periprosthetic fractures following primary total hip and knee arthroplasty.

Sci Rep

2023 May 2

Holzer LA, Borotschnig L, Holzer G.

804. The importance of structural, situational, and psychological factors for involving hunters in the adaptive flyway management of geese.

Sci Rep

2023 May 2

Eriksson L, Månsson J, Liljebäck N

805. Evaluation of the yield, chemical composition and biological properties of essential oil from bioreactor-grown cultures of Salvia apiana microshoots.

Sci Rep

2023 May 2

Krol A, Kokotkiewicz A, Gorniak M

806. Nono deficiency impedes the proliferation and adhesion of H9c2 cardiomyocytes through Pi3k/Akt signaling pathway.

Sci Rep

2023 May 2

Lei YQ, Ye ZJ, Wei YL

807. Preliminary evaluation of the safety and efficacy of glucose solution infusion through the hepatic artery on irreversible electroporation focusing.

Sci Rep

2023 May 2

Sarreshtehdari A, Burdio F, López-Alonso B

808. Multiple levels of contextual influence on action-based timing behavior and cortical activation.

Sci Rep

2023 May 2

Rahimpour Jounghani A, Lanka P, Pollonini L

809. Presence of Holmboe waves in particle-laden intrusive gravity current.

Sci Rep

2023 May 2

Rostami Dehjalali S, Khavasi E, Nazmi P.

810. A potential primary endpoint for clinical trials in glaucoma neuroprotection.

Sci Rep

2023 May 2

De Moraes CG, Lane KJ, Wang X

811. Filtration efficiency of medical and community face masks using viral and bacterial bioaerosols.

Sci Rep

2023 May 2

Djeghdir S, Peyron A, Sarry G

812. Comparison of ozonesonde measurements in the upper troposphere and lower Stratosphere in Northern India with reanalysis and chemistry-climate-model data.

Sci Rep

2023 May 2

Fadnavis S, Sagalgile A, Sonbawne S

813. UV-shielding properties of a cost-effective hybrid PMMA-based thin film coatings using TiO(2) and ZnO nanoparticles: a comprehensive evaluation.

Sci Rep

2023 May 2

Yousefi F(#), Mousavi SB(#), Heris SZ

814. A reduction from an LWE problem to maximum independent set problems.

Sci Rep

2023 May 2

Kawano Y.

815. Automatic resin duct detection and measurement from wood core images using convolutional neural networks.

Sci Rep

2023 May 2

Fabijańska A(#), Cahalan GD(#).

816. Lithium hydroxide as a high capacity adsorbent for CO(2) capture: experimental, modeling and DFT simulation.

Sci Rep

2023 May 2

Ahmadi M, Ghaemi A, Qasemnazhand M.

817. Origins of pressure dependent permeability in unconventional hydrocarbon reservoirs.

Sci Rep

2023 May 2

Valenza JJ 2nd, Kortunov P, Alzobaidi S

818. Dreams share phenomenological similarities with task-unrelated thoughts and relate to variation in trait rumination and COVID-19 concern.

Sci Rep

2023 May 2

Raffaelli Q(#), Andrews ES(#), Cegavske CC

819. Comparative analysis of productive performance and fattening efficiency of commercial pigs in China for two consecutive years.

Sci Rep

2023 May 19

Guan R, Wu J, Wang Y

(1) propose an evaluation indicator of the fattening efficiency of commercial pigs (Yorkshire × Landrace × Duroc)-fattening efficiency index (FEI). (2) Analyze the correlation to find the main productive factors affecting the FEI. (3) Compare and analyze the yearly/monthly/different piglets' sources of productive performance in 2020 and 2021. The data included 2592 commercial pig batches in 2020 and 3266 in 2021, with a total of 6,134,234 commercial pigs. Descriptive statistics and difference analysis were carried out on 16 productive factors of a whole year and single/multiple sources for two consecutive years. The same period difference between the monthly data and the annual average were also analyzed. The top six productive factors correlated with FEI were average daily gain (ADG) (0.8080), feed conversion rate (FCR) (- 0.7203), survival rate (SR) (0.6968), number of deaths (- 0.4103), feeding days (- 0.3748) and body weight (BW) of marketing pigs (0.3369). The overall productive performance in 2021 was lower than that in 2020, which was reflected in more piglet sources and a lower BW of piglets, more deaths, a lower SR, longer feeding days, a lower ADG, a higher FCR and a lower FEI. The productive performance of a single source was better than that of multiple ones. The contrastive results of monthly data in 2020 and 2021 showed significant differences in most factors except for the number of marketing pigs, the number of piglets and feed consumption. The monthly trend of 15 factors for two consecutive years revealed similar trends only in the month of piglets purchasing, number of piglets sources, number of deaths and ADG. Compared with the annual average, the ADG significantly increased in May. The FEI of multiple sources was markedly lower than that of a single source. FEI may be suitable for evaluating the fattening efficiency of commercial pigs. The annual and monthly productive performance and fattening efficiency in 2021 were significantly lower than those in 2020. Single source was represented better productive performance and fattening efficiency than multiple ones.

820. Reconstructing the earliest known composite-tiled roofs from the Chinese Loess Plateau.

Sci Rep

2023 May 19

Xu Y(#), Zhou J(#), Zhao J

821. Cognitive exertion affects the appraisal of one's own and other people's pain.

Sci Rep

2023 May 19

Riontino L, Fournier R, Lapteva A

822. Endometriosis increases the risk of gestational diabetes: a meta-analysis stratified by mode of conception, disease localization and severity.

Sci Rep

2023 May 19

Salmeri N, Li Piani L, Cavoretto PI

823. Bidirectional meta-Kronecker factored optimizer and Hausdorff distance loss for few-shot medical image segmentation.

Sci Rep

2023 May 19

Kim Y, Kang D, Mok Y

824. Intra-pulse difference frequency generation in ZnGeP(2) for high-frequency terahertz radiation generation.

Sci Rep

2023 May 19

Carnio BN, Zhang M, Zawilski KT

825. Bioinformatic analysis and experimental validation of the potential gene in the airway inflammation of steroid-resistant asthma.

Sci Rep

2023 May 19

Wei C(#), Wang Y(#), Hu C.

826. Long- COVID and general health status in hospitalized COVID-19 survivors.

Sci Rep

2023 May 19

Mohtasham-Amiri Z, Keihanian F, Rad EH

827. The relationship between heart rate variability and TNM stage, co-morbidity, systemic inflammation and survival in patients with primary operable colorectal cancer.

Sci Rep

2023 May 19

McGovern J, Leadbitter S, Miller G

828. Cleaner technologies for asphalt mixtures combining reuse of residual aggregates, waste crumb rubber and warm mix asphalt additive.

Sci Rep

2023 May 19

Franesqui MA, Rodríguez-Alloza AM, Yepes J

829. Area-level associations of travel behaviour metrics with waist circumference: findings from linkage of travel and health surveys.

Sci Rep

2023 May 19

Sugiyama T, Cole R, Hadgraft N

830. The effect of decellularization protocols on characterizations of thermoresponsive and light-curable corneal extracellular matrix hydrogels.

Sci Rep

2023 May 19

Yazdanpanah G(#), Jalilian E(#), Shen X

To compare the effects of two decellularization protocols on the characteristics of fabricated COrnea Matrix (COMatrix) hydrogels. Porcine corneas were decellularized with Detergent (De) or Freeze-Thaw (FT)-based protocols. DNA remnant, tissue composition and α-Gal epitope content were measured. The effect of α-galactosidase on α-Gal epitope residue was assessed. Thermoresponsive and light-curable (LC) hydrogels were fabricated from decellularized corneas and characterized with turbidimetric, light-transmission and rheological experiments. The cytocompatibility and cell-mediated contraction of the fabricated COMatrices were assessed. Both protocols reduced the DNA content to < 0.1 µg/mg (native, > 0.5 µg/mg), and preserved the collagens and glycosaminoglycans. The α-Gal epitope remnant decreased by > 50% following both decellularization methods. We observed more than 90% attenuation in α-Gal epitope after treatment with α-galactosidase. The thermogelation half-time of thermoresponsive COMatrices derived from De-Based protocol (De-COMatrix) was 18 min, similar to that of FT-COMatrix (21 min). The rheological characterizations revealed significantly higher shear moduli of thermoresponsive FT-COMatrix (300.8 ± 22.5 Pa) versus De-COMatrix 178.7 ± 31.3 Pa, p < 0.01); while, this significant difference in shear moduli was preserved after fabrication of FT-LC-COMatrix and De-LC-COMatrix (18.3 ± 1.7 vs 2.8 ± 2.6 kPa, respectively, p < 0.0001). All thermoresponsive and light-curable hydrogels have similar light-transmission to human corneas. Lastly, the obtained products from both decellularization methods showed excellent in vitro cytocompatibility. We found that FT-LC-COMatrix was the only fabricated hydrogel with no significant cell-mediated contraction while seeded with corneal mesenchymal stem cells (p < 0.0001). The significant effect of decellularization protocols on biomechanical properties of hydrogels derived from porcine corneal ECM should be considered for further applications.

831. The perception of COVID-19, the Light Triad, harmony and ethical sensitivity in late adolescents: The role of meaning-making and stress.

Sci Rep

2023 May 19

Krok D, Zarzycka B, Telka E.

832. AI for identifying social norm violation.

Sci Rep

2023 May 19

Neuman Y, Cohen Y.

833. A versatile method to fingerprint and compare the oxidative behaviour of lipids beyond their oxidative stability.

Sci Rep

2023 May 19

Pizzimenti S, Bernazzani L, Duce C

834. Discovery of andrographolide hit analog as a potent cyclooxygenase-2 inhibitor through consensus MD-simulation, electrostatic potential energy simulation and ligand efficiency metrics.

Sci Rep

2023 May 19

Jain P, Satija J, Sudandiradoss C.

835. Novel start codons introduce novel coding sequences in the human genomes.

Sci Rep

2023 May 19

Zhang H, Xie Y.

836. Relationship between adult attachment and cognitive emotional regulation style in women and men.

Sci Rep

2023 May 19

Delgado B, Amor PJ, Domínguez-Sánchez FJ

837. Earthquake-induced soil landslides: volume estimates and uncertainties with the existing scaling exponents.

Sci Rep

2023 May 19

Yunus AP(#), Xinyu C(#), Catani F

838. Resistance to the larvicide temephos and altered egg and larval surfaces characterize salinity-tolerant Aedes aegypti.

Sci Rep

2023 May 19

Sivabalakrishnan K, Thanihaichelvan M, Tharsan A

839. Evaluation of rosuvastatin-induced QT prolongation risk using real-world data, in vitro cardiomyocyte studies, and mortality assessment.

Sci Rep

2023 May 19

Koo Y(#), Hyun SA(#), Choi BJ

840. Adsorption behavior of furan at Ge(100) surface.

Sci Rep

2023 May 19

Nam JW, Lee HK, Kim BS

841. Non-coaxial deformation of foreland basement involved in a fold-and-thrust belt: a strain partitioning approach to the Eastern Variscan orogen.

Sci Rep

2023 May 19

Mareček L, Melichar R, Černý J

842. Sulfur metabolism in subtropical marine mangrove sediments fundamentally differs from other habitats as revealed by SMDB.

Sci Rep

2023 May 19

Mo S, Yan B, Gao T

843. Optimal strategy of the simultaneous dice game Pig for multiplayers: when reinforcement learning meets game theory.

Sci Rep

2023 May 19

Zhu T, Ma M, Chen L

844. Pinostrobin, a fingerroot compound, regulates miR-181b-5p and induces acute leukemic cell apoptosis.

Sci Rep

2023 May 19

Norkaew C, Subkorn P, Chatupheeraphat C

845. Community detection in multi-frequency EEG networks.

Sci Rep

2023 May 19

Karaaslanli A, Ortiz-Bouza M, Munia TTK

846. Mir-183 functions as an oncogene via decreasing PTEN in breast cancer cells.

Sci Rep

2023 May 19

Mohammaddoust S, Sadeghizadeh M.

847. Accurate drusen segmentation in optical coherence tomography via order-constrained regression of retinal layer heights.

Sci Rep

2023 May 19

Morelle O, Wintergerst MWM, Finger RP

848. The association between dietary diabetic risk reduction score with anthropometric and body composition variables in overweight and obese women: a cross-sectional study.

Sci Rep

2023 May 19

Karimi M, Shiraseb F, Mofidi M

Dietary diabetes risk reduction score (DDRRs) is inversely associated with a lower risk of type 2 diabetes. Given the importance of the association between body fat and insulin resistance and the effect of diet on these parameters, this study aimed to investigate the association between DDRRS and body composition parameters, including the visceral adiposity index (VAI), lipid accumulation product (LAP), and skeletal muscle mass (SMM). This study was conducted on 291 overweight and obese women aged 18-48 years old recruited from 20 Tehran Health Centers in 2018. The anthropometric indices, biochemical parameters, and body composition were measured. A semi-quantitative food frequency questionnaire (FFQ) was used to calculate DDRRs. Linear regression analysis was used to examine the association between DDRRs and body composition indicators. The mean (SD) age of participants was 36.67 (9.10) years. After adjustment for potential confounders, VAI (β = 0.27, 95% CI = - 0.73, 1.27, Ptrend = 0.052), LAP (β = 8.14, 95% CI = - 10.54, 26.82, Ptrend = 0.069), TF (β = - 1.41, 95% CI = 11.45, 17.30, Ptrend = 0.027), trunk fat percent (TF%) (β = - 21.55, 95% CI = - 44.51, 1.61, Ptrend = 0.074), body fat mass (BFM) (β = - 3.26, 95% CI = - 6.08, - 0.44, Ptrend = 0.026), visceral fat area (VFA) (β = - 45.75, 95% CI = - 86.10, - 5.41, Ptrend = 0.026), waist-to-hip ratio (WHtR) (β = - 0.014, 95% CI = - 0.031, 0.004, Ptrend = 0.066), visceral fat level (VFL) (β = - 0.38, 95% CI = - 5.89, 5.12, Ptrend = 0.064), fat mass index (FMI) (β = - 1.15, 95% CI = - 2.28, - 0.02, Ptrend = 0.048) decreased significantly over tertiles of DDRRs, and also there was no significant association between SMM and DDRRs tertiles (β = - 0.57, 95% CI = - 1.69, 0.53, Ptrend = 0.322). The findings of this study demonstrated that participants with higher adherence to the DDRRs had lower VAI (β = 0.78 vs 0.27) and LAP (β = 20.73 vs 8.14). However, there was no significant association between DDRRs and VAI, LAP and SMM, which are mentioned as the primary outcomes. Future studies with larger sample of both genders are needed to investigate our findings.

849. Phenotyping floral traits and essential oil profiling revealed considerable variations in clonal selections of damask rose (Rosa damascena Mill.).

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2023 May 19

Kumar A, Gautam RD, Singh S

850. Changes in resource perception throughout the foraging visit contribute to task specialization in the honey bee Apis mellifera.

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2023 May 19

Moreno E, Arenas A.

851. Amplification of ammonia sensing performance through gate induced carrier modulation in Cur-rGO Silk-FET.

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2023 May 19

Sett A(#), Sarkar L(#), Majumder S

852. Development, fabrication and mechanical characterisation of auxetic bicycle handlebar grip.

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2023 May 19

Novak N, Plesec V, Harih G

853. Analysis of risk factors for postoperative mortality in acute type A aortic dissection patients under different critical levels.

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2023 May 19

Zhu X(#), Wang J(#), Chong H(#)

854. Comparing the effects of four common drug classes on the progression of mild cognitive impairment to dementia using electronic health records.

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2023 May 19

Xu J, Wang F, Zang C

855. Adaptive neural network prescribed performance control for dual switching nonlinear time-delay system.

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2023 May 19

Mu Q, Long F, Li B.

856. Noradrenergic stimulation of α(1) adrenoceptors in the medial prefrontal cortex mediates acute stress-induced facilitation of seizures in mice.

Sci Rep

2023 May 19

Niitani K, Ito S, Wada S

857. Information load dynamically modulates functional brain connectivity during narrative listening.

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2023 May 19

Mastrandrea R(#), Cecchetti L(#), Lettieri G

858. Biophotonic sensor for swift detection of malignant brain tissues by using nanocomposite YBa(2)Cu(3)O(7)/dielectric material as a 1D defective photonic crystal.

Sci Rep

2023 May 19

Malek C, Abdallah SAO, Awasthi SK

859. Self-modulation of rectus femoris reflex excitability in humans.

Sci Rep

2023 May 19

Kim K, Akbas T, Lee R

860. Unsupervised machine learning effectively clusters pediatric spastic cerebral palsy patients for determination of optimal responders to selective dorsal rhizotomy.

Sci Rep

2023 May 19

Hou X(#), Yan Y(#), Zhan Q

Selective dorsal rhizotomy (SDR) can reduce the spasticity in patients with spastic cerebral palsy (SCP) and thus improve the motor function in these patients, but different levels of improvement in motor function were observed among patients after SDR. The aim of the present study was to subgroup patients and to predict the possible outcome of SDR based on the pre-operational parameters. A hundred and thirty-five pediatric patients diagnosed with SCP who underwent SDR from January 2015 to January 2021 were retrospectively reviewed. Spasticity of lower limbs, the number of target muscles, motor functions, and other clinical parameters were used as input variables for unsupervised machine learning to cluster all included patients. The postoperative motor function change is used to assess the clinical significance of clustering. After the SDR procedure, the spasticity of muscles in all patients was reduced significantly, and the motor function was promoted significantly at the follow-up duration. All patients were categorized into three subgroups by both hierarchical and K-means clustering methods. The three subgroups showed significantly different clinical characteristics except for the age at surgery, and the post-operational motor function change at the last follow-up in these three clusters was different. Three subgroups clustered by two methods could be identified as "best responders", "good responders" and "moderate responders" based on the increasement of motor function after SDR. Clustering results achieved by hierarchical and K-means algorithms showed high consistency in subgrouping the whole group of patients. These results indicated that SDR could relieve the spasticity and promote the motor function of patients with SCP. Unsupervised machine learning methods can effectively and accurately cluster patients into different subgroups suffering from SCP based on pre-operative characteristics. Machine learning can be used for the determination of optimal responders for SDR surgery.

861. Rapid and efficient ambient temperature X-ray crystal structure determination at Turkish Light Source.

Sci Rep

2023 May 19

Gul M, Ayan E, Destan E

862. Bayesian forecasting of disease spread with little or no local data.

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2023 May 19

Cook JD, Williams DM, Walsh DP

863. Ivermectin metabolites reduce Anopheles survival.

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2023 May 19

Kobylinski KC, Tipthara P, Wamaket N

864. Secular trend analysis of antibiotic utilisation in some hospitals in Southern Sichuan from 2010 to 2020.

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2023 May 19

Wu Z(#), Li Y(#), Li R

865. Prosaposin PS18 reduces dopaminergic neurodegeneration in a 6-hydroxydopamine rat model of Parkinson's disease.

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2023 May 19

Wu KJ, Hung TW, Wang YS

866. Solubility measurement and modeling of hydroxychloroquine sulfate (antimalarial medication) in supercritical carbon dioxide.

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2023 May 19

Sodeifian G, Garlapati C, Arbab Nooshabadi M

867. Influence of face masks on the subjective impairment at different physical workloads.

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2023 May 19

van Kampen V, Marek EM, Sucker K

868. Wafer map failure pattern classification using geometric transformation-invariant convolutional neural network.

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2023 May 19

Jeong I, Lee SY, Park K

869. Prevalence and clinical correlates of abnormal lipid metabolism in first-episode and drug-naïve patients with major depressive disorder with abnormal glucose metabolism.

Sci Rep

2023 May 18

Zhu Q(#), Jiang G(#), Lang X

870. Machine learning-based predictive models for the occurrence of behavioral and psychological symptoms of dementia: model development and validation.

Sci Rep

2023 May 18

Cho E, Kim S, Heo SJ

871. Spatiotemporal bias of the human gaze toward hierarchical visual features during natural scene viewing.

Sci Rep

2023 May 18

Akamatsu K, Nishino T, Miyawaki Y.

872. Exposure to halogenated ethers causes neurodegeneration and behavioural changes in young healthy experimental animals: a systematic review and meta analyses.

Sci Rep

2023 May 18

Hooijmans CR, Buijs M, Struijs F

The FDA issued a warning that repeated and prolonged use of inhalational anaesthetics in children younger than 3 years may increase the risk of neurological damage. Robust clinical evidence supporting this warning is however lacking. A systematic review of all preclinical evidence concerning isoflurane, sevoflurane, desflurane and enflurane exposure in young experimental animals on neurodegeneration and behaviour may elucidate how severe this risk actually is PubMed and Embase were comprehensively searched on November 23, 2022. Based on predefined selection criteria the obtained references were screened by two independent reviewers. Data regarding study design and outcome data (Caspase-3 and TUNEL for neurodegeneration, Morris water maze (MWM), Elevated plus maze (EPM), Open field (OF) and Fear conditioning (FC)) were extracted, and individual effect sizes were calculated and subsequently pooled using the random effects model. Subgroup analyses were predefined and conducted for species, sex, age at anesthesia, repeated or single exposure and on time of outcome measurement. Out of the 19.796 references screened 324 could be included in the review. For enflurane there were too few studies to conduct meta-analysis (n = 1). Exposure to sevoflurane, isoflurane and desflurane significantly increases Caspase-3 levels and TUNEL levels. Further, sevoflurane and isoflurane also cause learning and memory impairment, and increase anxiety. Desflurane showed little effect on learning and memory, and no effect on anxiety. Long term effects of sevoflurane and isoflurane on neurodegeneration could not be analysed due to too few studies. For behavioural outcomes, however, this was possible and revealed that sevoflurane caused impaired learning and memory in all three related outcomes and increased anxiety in the elevated plus maze. For isoflurane, impaired learning and memory was observed as well, but only sufficient data was available for two of the learning and memory related outcomes. Further, single exposure to either sevoflurane or isoflurane increased neurodegeneration and impaired learning and memory. In summary, we show evidence that exposure to halogenated ethers causes neurodegeneration and behavioural changes. These effects are most pronounced for sevoflurane and isoflurane and already present after single exposure. To date there are not sufficient studies to estimate the presence of long term neurodegenerative effects. Nevertheless, we provide evidence in this review of behavioral changes later in life, suggesting some permanent neurodegenerative changes. Altogether, In contrast to the warning issued by the FDA we show that already single exposure to isoflurane and sevoflurane negatively affects brain development. Based on the results of this review use of sevoflurane and isoflurane should be restrained as much as possible in this young vulnerable group, until more research on the long term permanent effects have been conducted.

873. A new spinosaurid dinosaur species from the Early Cretaceous of Cinctorres (Spain).

Sci Rep

2023 May 18

Santos-Cubedo A, de Santisteban C(#), Poza B(#)

874. Gait speed and individual characteristics are related to specific gait metrics in neurotypical adults.

Sci Rep

2023 May 18

Bonilla Yanez M, Kettlety SA, Finley JM

875. Genetic mutations linked to field-evolved Cry1Fa-resistance in the European corn borer, Ostrinia nubilalis.

Sci Rep

2023 May 18

Farhan Y, Smith JL, Sovic MG

876. Risk factors associated with football injury among male players from a specific academy in Ghana: a pilot study.

Sci Rep

2023 May 18

Kwakye SK, Mostert K, Garnett D

There seems to be no information on the incidence of injury and associated risk factors for academy football players in Ghana. We determine the risk factors associated with match and training injuries among male football players at an academy in Ghana. Preseason measurements of players' height, weight, and ankle dorsiflexion (DF) range of motion (ROM) were measured with a stadiometer (Seca 213), a digital weighing scale (Omron HN-289), and tape measure, respectively. The functional ankle instability (FAI) of players was measured using the Cumberland Ankle Instability Tool (CAIT), and dynamic postural control was measured with the Star Excursion Balance Test. Injury surveillance data for all injuries were collected by resident physiotherapists throughout one season. Selected factors associated with injury incidence were tested using Spearman's rank correlation at a 5% significance level. Age was negatively associated with overall injury incidence (r = - 0.589, p = 0.000), match (r = - 0.294, p = 0.008), and training incidence (r = - 0.314, p = 0.005). Previous injury of U18s was associated with training injuries (r = 0.436, p = 0.023). Body mass index (BMI) was negatively associated with overall injury incidence (r = - 0.513, p = 0.000), and training incidence (r = - 0.395, p = 0.000). CAIT scores were associated with overall injury incidence (n = 0.263, p = 0.019) and match incidence (r = 0.263, p = 0.029). The goalkeeper position was associated with match incidence (r = 0.241, p = 0.031) while the U16 attacker position was associated with training incidence. Exposure hours was negatively associated with overall injury incidence (r = - 0.599, p = 0.000). Age, BMI, previous injury, goalkeeper and attacker positions, ankle DF ROM, and self-reported FAI were associated with injury incidence among academy football players in Ghana.

877. Improved water purification by PVDF ultrafiltration membrane modified with GO-PVA-NaAlg hydrogel.

Sci Rep

2023 May 18

Ghobadi Moghadam A, Hemmati A.

878. Revealing the immune cell subtype reconstitution profile in patients from the CLARITY study using deconvolution algorithms after cladribine tablets treatment.

Sci Rep

2023 May 18

Kalatskaya I, Giovannoni G, Leist T

879. Cognitive test performance in chronic cannabis flower users, concentrate users, and non-users.

Sci Rep

2023 May 18

Cuttler C, Petrucci AS, LaFrance EM.

880. Ammonia oxidizing archaea and bacteria respond to different manure application rates during organic vegetable cultivation in Northwest China.

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2023 May 18

Wang Z, Li Y, Zheng W

881. Application of non-degradable waste as building material for low-cost housing.

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2023 May 18

Zuraida S, Dewancker B, Margono RB.

882. Swept-source multimode fiber imaging.

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2023 May 18

Lochocki B, Ivanina A, Bandhoe A

883. Developing OCHROdb, a comprehensive quality checked database of open chromatin regions from sequencing data.

Sci Rep

2023 May 18

Shooshtari P, Feng S, Nelakuditi V

884. Fast response and recovery polyaniline montmorillonite reduce graphene oxide polymer nanocomposite material for detection of hydrogen cyanide gas.

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2023 May 18

Singh A, Dipak P, Iqbal A

885. Scrutinizing joint remote state preparation under decoherence.

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2023 May 18

Iyen C, Falaye BJ(#), Liman MS(#).

886. Phytochemical screening and allelopathic potential of phytoextracts of three invasive grass species.

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2023 May 18

Jabeen S(#), Ali MF(#), Mohi Ud Din A

Undoubtedly, it is important to remain vigilant and manage invasive grasses to prevent their spread and mitigate their negative impact on the environment. However, these aggressive plants can also play a beneficial role in certain contexts. For example, several invasive grasses provide valuable forage for livestock and have disease control potential. Therefore, a research experiment was conducted to explore the pros and cons of this approach, not only for surrounding vegetation but also for human and animal disease control. The study is primarily focused on developing livestock feed, plant-derived herbicides, and an understanding of the phytotoxic effects of invasive species. All plant parts of Cenchrus ciliaris L., Polypogon monspeliansis L., and Dicanthium annulatum (Forssk.) Stapf, were tested for their phyto-chemical screening, proximate, and toxicity analysis which was caused by the methanolic extract of these grass species. Qualitative phytochemical screening tests were performed for proximate composition analysis and toxicity assessment essays. The phytochemical analysis revealed the positive results for alkaloids, flavonoids, coumarins, phenols, saponins, and glycosides, while negative for tannins. Comparison of proximate analysis intimated maximum moisture (10.8%) and crude fat (4.1%) in P. monspeliensis, whereas maximum dry matter (84.1%), crude protein (13.95%), crude fiber (11%), and ash (7.2%) in D. annulatum. Five (10, 100, 500, 100, 10,000 ppm) and three (10, 1000, 10,000 ppm) different concentrations of methanolic extract prepared from C. ciliaris, P. monspeliansis, and D. annulatum were used respectively for root inhibition and seed germination essay. Furthermore, three different concentrations (10, 30, 50 mg) of plant fine powder were used for sandwich method test. There was a significant decline in the growth rate of experimental model radish seeds (P > 0.005), and results from sandwich method tests showed suppressed growth of root hairs, inhibiting the anchoring of the radish seed. In comparison, results manifest that; P. monspeliansis indicated an upsurge of inhibition (66.58% at 10,000 ppm), D. annulatum revealed soar germination (75.86% in controlled conditions), and C. ciliaris exhibited dramatic shoot up of inhibition because of sandwich method test (14.02% at 50 mg). In conclusion, although grasses are toxic, it is important to consider the beneficiary account.

887. An organ-on-chip device with integrated charge sensors and recording microelectrodes.

Sci Rep

2023 May 18

Aydogmus H, Hu M, Ivancevic L

888. Geomorphological assessment of the preservation of archaeological tell sites.

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2023 May 18

Forti L, Brandolini F, Oselini V

889. Comprehensive evaluation of zeolite/marine alga nanocomposite in the removal of waste dye from industrial wastewater.

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2023 May 18

Hamd A, Shaban M, Al-Senani GM

890. Applying appropriate frequency criteria to advance acoustic behavioural guidance systems for fish.

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2023 May 18

Holgate A, White PR, Leighton TG

891. A multi-analytical approach to studying the chemical composition of typical carbon sink samples.

Sci Rep

2023 May 17

Astolfi ML, Massimi L, Rapa M

892. The role of genetic polymorphisms of interleukin-1 (IL-1R1 and IL-1RN) in primary knee osteoarthritis in Indonesia.

Sci Rep

2023 May 17

Budhiparama NC, Lumban-Gaol I, Sudoyo H

893. Wavelet clustering analysis as a tool for characterizing community structure in the human microbiome.

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2023 May 17

Benincà E, Pinto S, Cazelles B

894. Ethiopian orthodox fasting is associated with weight reduction and body composition changes among healthy adults: a prospective cohort study.

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2023 May 17

Michael A, Baye K.

895. Sophorolipid inhibits histamine-induced itch by decreasing PLC/IP3R signaling pathway activation and modulating TRPV1 activity.

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2023 May 17

Xu RQ, Ma L, Chen T

896. Comparison of partial nephrectomy and radical nephrectomy for cystic renal cell carcinoma: a SEER-based and retrospective study.

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2023 May 17

Lin W(#), Yang Z(#), Yan L(#)

897. Multifunctional twelve port frequency agile diversity antenna for indoor wireless applications.

Sci Rep

2023 May 17

Thangarasu D, Palaniswamy SK, Thipparaju RR

898. Monitoring and analysis of ground subsidence in Shanghai based on PS-InSAR and SBAS-InSAR technologies.

Sci Rep

2023 May 17

Zhang Z, Hu C, Wu Z

Shanghai is susceptible to land subsidence due to its unique geological environment and frequent human activities. Traditional leveling techniques are not sufficient for monitoring large areas of land subsidence due to the time-consuming, labor-intensive, and expensive nature of the process. Furthermore, the results of conventional methods may not be timely, rendering them ineffective for monitoring purposes. Interferometric Synthetic Aperture Radar (InSAR) technology is a widely used method for monitoring ground subsidence due to its low cost, high efficiency, and ability to cover large areas. To monitor the surface sink condition of Shanghai over the past 2 years, monitoring data were obtained through the technical processing of 24 images from Sentinel-1A data covering Shanghai from 2019 to 2020 using the Persistent Scatterer (PS-InSAR) and Small Baseline Subset (SBAS-InSAR) technique. The ground subsidence (GS) results were extracted via PS and SBAS interferometry processing, while Shuttle Radar Topography Mission data were used to correct the residual phase. According to PS and SBAS methods, the maximum ground subsidence in the study area reached 99.8 mm and 47.2 mm, respectively. The subsidence rate and the accumulated amount of subsidence derived from the monitoring results revealed the urban area in Shanghai to be principally characterized by uneven GS, with multiple settlement funnels being found to be distributed across the main urban area. Moreover, when compared with the historical subsidence data, geological data, and urban construction distribution data, the individual settlement funnels were observed to correspond to those data concerning the historical surface settlement funnel in Shanghai. By randomly selecting GS time-series data regarding three feature points, it was determined that the morphological variables of the GS remained largely consistent at all time points and that their change trends exhibited a high degree of consistency, which verified the reliability of the PS-InSAR and SBAS-InSAR monitoring method. The results can provide data support for decision making in terms of geological disaster prevention and control in Shanghai.

899. Regulation of whole-body angular momentum during human walking.

Sci Rep

2023 May 17

Negishi T, Ogihara N.

900. DARPins bind their cytosolic targets after having been translocated through the protective antigen pore of anthrax toxin.

Sci Rep

2023 May 17

Becker L, Plückthun A.

901. Effects of folic acid supplementation in pregnant mice on glucose metabolism disorders in male offspring induced by lipopolysaccharide exposure during pregnancy.

Sci Rep

2023 May 17

Sun WX, Shu YP, Yang XY

902. Nonlinear and machine learning analyses on high-density EEG data of math experts and novices.

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2023 May 17

Poikonen H, Zaluska T, Wang X

903. Cell activation-based screening of natively paired human T cell receptor repertoires.

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2023 May 17

Fahad AS(#), Chung CY(#), López Acevedo SN

904. Combined structural analysis and cathodoluminescence investigations of single Pr(3+)-doped Ca(2)Nb(3)O(10) nanosheets.

Sci Rep

2023 May 17

Changizi R, Zaefferer S, Ziegler C

905. UHPLC-HRMS-based metabolomic and lipidomic characterization of glioma cells in response to anlotinib.

Sci Rep

2023 May 17

Shi Y, Li Z, Du Q

906. Happiness predicts compliance with preventive health behaviours during Covid-19 lockdowns.

Sci Rep

2023 May 17

Krekel C(#), Swanke S(#), De Neve JE

907. Diagnostic role of aortic valve calcium scoring in various etiologies of aortic stenosis.

Sci Rep

2023 May 17

Wanchaitanawong W, Kanjanavanit R, Srisuwan T

908. Integrative Mendelian randomization reveals the soluble receptor for advanced glycation end products as protective in relation to rheumatoid arthritis.

Sci Rep

2023 May 17

Lee GY, Yao C, Hwang SJ

909. Liver-specific overexpression of HKDC1 increases hepatocyte size and proliferative capacity.

Sci Rep

2023 May 17

Pusec CM, Ilievski V, De Jesus A

910. Heterosis patterns and sources of self-compatibility, cross-compatibility and key nut traits within single and double hybrid crosses of kola [Cola nitida (Vent) Schott and Endl.].

Sci Rep

2023 May 17

Nyadanu D, Lowor ST, Pobee P

911. Pharmacological inhibition of BCL-2 with the FDA-approved drug venetoclax impairs longitudinal bone growth.

Sci Rep

2023 May 17

Velentza L, Wickström M, Kogner P

912. Adding virtual plants leads to higher cognitive performance and psychological well-being in virtual reality.

Sci Rep

2023 May 17

Mostajeran F, Steinicke F, Reinhart S

913. Microbial communities and their roles in the Cenozoic sulfurous oil reservoirs in the Southwestern Qaidam Basin, Western China.

Sci Rep

2023 May 17

Jiao Y, An L, Wang W

914. Evolutionary success of the thrifty genotype depends on both behavioral adaptations and temporal variability in the food environment.

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2023 May 17

Batta E(#), Stephens CR(#).

915. Effect of cetrimonium carrier micelles on bacterial membranes and extracellular DNA, an in silico study.

Sci Rep

2023 May 17

Puelles JS, Ghorbani M, Tuck B

Microorganisms do not live as dispersed single cells but rather they form aggregates with extracellular polymeric substances at interfaces. Biofilms are considered efficient life forms because they shield bacteria from biocides and collect dilute nutrients. This is a big concern in industry since the microorganisms can colonize a wide range of surfaces, accelerating material deterioration, colonizing medical devices, contaminating ultrapure drinking water, increasing energy costs and creating focus of infection. Conventional biocides that target a specific component of the bacteria are not effective in the presence of biofilms. Efficient biofilm inhibitors are based on a multitarget approach interacting with the bacteria and the biofilm matrix. Their rationale design requires a thorough understanding of inhibitory mechanisms that are still largely lacking today. Herein we uncover via molecular modelling the inhibition mechanism of cetrimonium 4-OH cinnamate (CTA-4OHcinn). Simulations show that CTA-4OH micelles can disrupt symmetric and asymmetric bilayers, representative of inner and outer bacterial membranes, following three stages: adsorption, assimilation, and defect formation. The main driving force for micellar attack is electrostatic interactions. In addition to disrupting the bilayers, the micelles work as carriers facilitating the trapping of 4OH cinnamate anions within the bilayer upper leaflet and overcoming electrostatic repulsion. The micelles also interact with extracellular DNA (e-DNA), which is one of the main components of biofilms. It is observed that CTA-4OHcinn forms spherical micelles on the DNA backbone; which hinders their ability to pack. This is demonstrated by modelling the DNA along the hbb histone-like protein, showing that in the presence of CTA-4OHcinn, DNA does not pack properly around hbb. The abilities of CTA-4OHcinn to cause cell death through membrane disruption and to disperse a mature, multi-species biofilm are also confirmed experimentally.

916. The impact of birth weight, birth order, birth asphyxia, and colostrum intake per se on growth and immunity of the suckling piglets.

Sci Rep

2023 May 17

Vodolazska D, Feyera T, Lauridsen C.

Colostrum is the only source of passive immunity and the major source of nutrients and is crucial for thermoregulation of newborn piglets in their early life. However, the amount of colostrum obtained by each piglet [colostrum intake (CI)] differs considerably in large litters as born by contemporary hyperprolific sow lines. This experiment aimed to investigate the impact of the following individual characteristics of piglets; birth weight, birth order and neonatal asphyxia at birth on CI, and further to determine the relationship between the CI and the passive immunity transfer, and the growth performance of piglets prior to weaning. Twenty-four Danbred sows of the second-parity and their progeny (n = 460) were used. As main inputs in the prediction model to assess individual piglet CI were piglet birth weight, their weight gain, and the duration of colostrum suckling of the piglets. The asphyxia (state of oxygen deprivation) was assessed by measuring blood lactate concentration immediately after birth, and piglets sampled at d 3 of age for determination of blood plasma concentrations of immunoglobulins (Ig) G, A, and M. Piglets' CI was negatively associated with asphyxia (P = 0.003), birth order (P = 0.005) and low birth weight have compromised the individual CI (P < 0.001). Average daily gain during the suckling period was greater among piglets with high CI (P = 0.001) and birth weight (P < 0.001). Body weight at weaning (d 24 of age) was positively associated with CI (P = 0.0004) and birth weight (P < 0.001). The probability of weaning was positively associated with CI and birth weight (P < 0.001) of the piglets. Concentrations of IgG (P = 0.02), IgA (P = 0.0007), and IgM (P = 0.04) in piglets' plasma at d 3 of age were positively associated with CI, and were negatively associated with birth order (P < 0.001). The present study demonstrated that piglets' individual characteristics at birth (birth weight, birth order, state of oxygen deprivation) have considerable effects on their CI. The knowledge gained from the results of this study gives a scientific base for development and implementation of more effective techniques in practice aimed to improve the piglets' robustness during the suckling period.

917. Functional and structural responses of plankton communities toward consecutive experimental heatwaves in Mediterranean coastal waters.

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2023 May 17

Soulié T, Vidussi F, Mas S

918. Machine learning-based country-level annual air pollutants exploration using Sentinel-5P and Google Earth Engine.

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2023 May 17

Halder B, Ahmadianfar I, Heddam S

919. The effect of sulfur baths on hemorheological properties of blood in patients with osteoarthritis.

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2023 May 17

Teległów A, Seremak J, Golec J

920. A critical assessment of a protected area conflict analysis based on secondary data in the age of datafication.

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2023 May 17

Rechciński M, Tusznio J, Akhshik A

921. Circulating miR-146b and miR-27b are efficient biomarkers for early diagnosis of Equidae osteoarthritis.

Sci Rep

2023 May 17

Yassin AM, AbuBakr HO, Abdelgalil AI

922. Comparative appraisal of mono and hybrid nanofluid flows comprising carbon nanotubes over a three-dimensional surface impacted by Cattaneo-Christov heat flux.

Sci Rep

2023 May 17

Alharbi KAM, Ramzan M, Shahmir N

923. Social networks are shaped by culturally contingent assessments of social competence.

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2023 May 17

Chadha S, Kleinbaum AM, Wood A.

924. Spirulina platensis improves growth, oil content, and antioxidant activitiy of rosemary plant under cadmium and lead stress.

Sci Rep

2023 May 17

Gharib FAEL, Ahmed EZ.

925. Ultrasound-Promoted preparation and application of novel bifunctional core/shell Fe(3)O(4)@SiO(2)@PTS-APG as a robust catalyst in the expeditious synthesis of Hantzsch esters.

Sci Rep

2023 May 17

Shakib P, Dekamin MG, Valiey E

In this work, D-(-)-α-phenylglycine (APG)-functionalized magnetic nanocatalyst (Fe3O4@SiO2@PTS-APG) was designed and successfully prepared in order to implement the principles of green chemistry for the synthesis of polyhydroquinoline (PHQ) and 1,4-dihydropyridine (1,4-DHP) derivatives under ultrasonic irradiation in EtOH. After preparing of the nanocatalyst, its structure was confirmed by different spectroscopic methods or techniques including Fourier transform infrared (FTIR) spectroscopy, energy-dispersive X-ray spectroscopy (EDS), field emission scanning electron microscopy (FESEM), X-ray diffraction (XRD), vibrating sample magnetometer (VSM) and thermal gravimetric analysis (TGA). The performance of Fe3O4@SiO2@PTS-APG nanomaterial, as a heterogeneous catalyst for the Hantzsch condensation, was examined under ultrasonic irradiation and various conditions. The yield of products was controlled under various conditions to reach more than 84% in just 10 min, which indicates the high performance of the nanocatalyst along with the synergistic effect of ultrasonic irradiation. The structure of the products was identified by melting point as well as FTIR and 1H NMR spectroscopic methods. The Fe3O4@SiO2@PTS-APG nanocatalyst is easily prepared from commercially available, lower toxic and thermally stable precursors through a cost-effective, highly efficient and environmentally friendly procedure. The advantages of this method include simplicity of the operation, reaction under mild conditions, the use of an environmentally benign irradiation source, obtaining pure products with high efficiency in short reaction times without using a tedious path, which all of them address important green chemistry principles. Finally, a reasonable mechanism is proposed for the preparation of polyhydroquinoline (PHQ) and 1,4-dihydropyridine (1,4-DHP) derivatives in the presence of Fe3O4@SiO2@PTS-APG bifunctional magnetic nanocatalyst.

926. The impact of methicillin resistance on clinical outcome among patients with Staphylococcus aureus osteomyelitis: a retrospective cohort study of 482 cases.

Sci Rep

2023 May 17

Wu H(#), Jia C(#), Wang X

927. Real time object detection using LiDAR and camera fusion for autonomous driving.

Sci Rep

2023 May 17

Liu H, Wu C, Wang H.

928. Antimicrobial activity of Limosilactobacillus fermentum strains isolated from the human oral cavity against Streptococcus mutans.

Sci Rep

2023 May 17

Park DY, Hwang J, Kim Y

929. Alpha radiation from polymetallic nodules and potential health risks from deep-sea mining.

Sci Rep

2023 May 17

Volz JB, Geibert W, Köhler D

930. NT-proBNP as a surrogate for unknown heart failure and its predictive power for peripheral artery disease outcome and phenotype.

Sci Rep

2023 May 17

Zierfuss B, Feldscher A, Höbaus C

931. Development and validation of a prediction equation for body fat percentage from measured BMI: a supervised machine learning approach.

Sci Rep

2023 May 17

Xu S(#), Nianogo RA(#), Jaga S

932. Essential oil yield and compositions of Dracocephalum moldavica L. in intercropping with fenugreek, inoculation with mycorrhizal fungi and bacteria.

Sci Rep

2023 May 17

Amiriyan Chelan Z, Amini R, Dabbagh Mohammadi Nasab A.

933. Designing continuous equilibrium structures that counteract gravity in any orientation.

Sci Rep

2023 May 17

Redoutey M, Filipov ET.

934. Structural and functional analyses of the echinomycin resistance conferring protein Ecm16 from Streptomyces lasalocidi.

Sci Rep

2023 May 17

Gade P, Erlandson A, Ullah A

935. An enzyme-free technique enables the isolation of a large number of adipose-derived stem cells at the bedside.

Sci Rep

2023 May 17

Yaylacı S, Kaçaroğlu D, Hürkal Ö

Adipose tissue derived stromal cells (ADSCs) play a crucial role in research and applications of regenerative medicine because they can be rapidly isolated in high quantities. Nonetheless, their purity, pluripotency, differentiation capacity, and stem cell marker expression might vary greatly depending on technique and tools used for extraction and harvesting. There are two methods described in the literature for isolating regenerative cells from adipose tissue. The first technique is enzymatic digestion, which utilizes many enzymes to remove stem cells from the tissue they reside in. The second method involves separating the concentrated adipose tissue using non-enzymatic, mechanical separation methods. ADSCs are isolated from the stromal-vascular fraction (SVF) of processed lipoaspirate, which is the lipoaspirate's aqueous portion. The purpose of this work was to evaluate a unique device 'microlyzer' for generating SVF from adipose tissue using a mechanical technique that required minimal intervention. The Microlyzer was examined using tissue samples from ten different patients. The cells that were retrieved were characterized in terms of their cell survival, phenotype, proliferation capacity, and differentiation potential. The number of progenitor cells extracted only from the microlyzed tissue was in comparable amount to the number of progenitor cells acquired by the gold standard enzymatic approach. The cells that were collected from each group exhibit similar levels of viability as well as proliferation rates. In addition, the differentiation potentials of the cells derived from the microlyzed tissue were investigated, and it was discovered that cells isolated through microlyzer entered the differentiation pathways more quickly and displayed a greater level of marker gene expression than cells isolated by enzymatic methods. These findings suggest that microlyzer, particularly in regeneration investigations, will allow quick and high rate cell separation at the bedside.

936. Ultrathin acoustic metamaterial as super absorber for broadband low-frequency underwater sound.

Sci Rep

2023 May 17

Zhou X, Wang X, Xin F.

937. Analysis of volatile compounds by GCMS reveals their rice cultivars.

Sci Rep

2023 May 17

Hu S, Ren H, Song Y

938. All boreal forest successional stages needed to maintain the full suite of soil biodiversity, community composition, and function following wildfire.

Sci Rep

2023 May 17

Porter TM, Smenderovac E, Morris D

939. An R&D perspective on international trade and sustainable development.

Sci Rep

2023 May 17

Costantini L, Laio F(#), Ridolfi L(#)

940. A pilot study for development of a pulmonary function test induction jacket to automate effort in performing the forced vital capacity manoeuvre.

Sci Rep

2023 May 17

Rajdeep P, Poorey K, Patel RK

941. Research on tire crack detection using image deep learning method.

Sci Rep

2023 May 17

Lin SL.

942. Effects of exogenous organic matter addition on agricultural soil microbial communities and relevant enzyme activities in southern China.

Sci Rep

2023 May 17

Liu X, Chen Q, Zhang H

Soil microbial community composition plays a key role in the decomposition of organic matter, while the quality of exogenous organic matter (EOM: rice straw, roots and pig manure) can influence soil chemical and biological properties. However, the evidences of the effect of combination of crop residues and pig manure on the changes in soil microbial community and enzymes activities are scarce. A greenhouse pot experiment was conducted to investigate the potential effect of EOM by analyzing soil properties, enzyme activities and microbial communities. The experiment consisted of eight treatments: CK (control), S (1% (w/w) rice straw), R (1% (w/w) rice root), SR (1% (w/w) rice straw + 1% (w/w) rice root), and added 1% (w/w) pig manure to CK, S, R and SR, respectively. Results showed that the straw treatment significantly increased the microbial biomass (carbon and nitrogen) and total carbon and nitrogen contents, cellulase and β-1,4-glucosidase activities, bacteria (i.e., gram-positive bacteria and gram-negative bacteria) PLFAs contents relative to CK regardless of whether pig manure was added. Moreover, the interaction between crop residues (e.g., straw and roots) and pig manure significantly influenced the contents of microbial biomass nitrogen and microbial biomass phosphorus, and the ratio of gram-positive bacteria to gram-negative bacteria. Redundance analysis confirmed that pH, nitrate nitrogen, ammonium nitrogen and dissolve organic carbon contents were significantly associated with soil microbial community under crop residues without pig manure addition. Furthermore, the experiment results showed that pig manure application not only provided more abundant nutrients (C, N and P) but also induced higher microbial and enzymatic activity compared with no pig manure addition. Our findings suggest that the combination of above-ground straw and pig manure is a better option for improving the functions of soil ecosystem.

943. Apigenin attenuates atherosclerosis and non-alcoholic fatty liver disease through inhibition of NLRP3 inflammasome in mice.

Sci Rep

2023 May 17

Lu Z, Liu L, Zhao S

944. AZAR eye and vision cohort study.

Sci Rep

2023 May 17

Somi MH, Nikniaz Z, Ostadrahimi A

According to World Health Organization (WHO), currently, 2.2 billion people are living with visual impairment worldwide, of which almost half could have been prevented. There are both modifiable and unmodifiable factors leading to visual disability and, ultimately, blindness. Several population-based studies in different parts of Iran have tried to determine these factors concerning their specific population and environment-related characteristics. AZAR Eye and Vision cohort is the second-largest cohort study in the whole country. AZAR Eye and Vision cohort is the ophthalmologic branch of AZAR cohort which is the largest eye cohort study in the country, which is trying to determine the prevalence and incidence of visual impairment, blindness, and other major ophthalmologic conditions and their associated risk factors in East Azerbaijan province located in Iran, a middle eastern country. A recently emerging phenomenon is the drying of the ultra-salty lake of Urmia located in the West Azerbaijan province which is a direct neighbor of our studied population and has caused recurrent salt storms in the immediate near areas. This phenomenon could adversely affect visual health via different conditions which our study will elucidate. The enrollment phase took place between 2014 and 2017 and 11,208 participants were enrolled out of 15,000 participants in the primary cohort. The resurvey phase will begin five years after the enrollment phase. In this phase, 30% of the participants are randomly selected to be reexamined and complete questionnaires. The participants showing any issues such as diabetes and being a glaucoma suspect will be included in the resurvey phase, too. Data categories gathered include demographics, lifestyle factors, past medical and drug histories, and a diet quality and quantity questionnaire including 130 edible items. Urine, hair, nail, and 25-ml blood samples, were collected from the participants. Then they were referred to an optometrist to complete an ophthalmologic questionnaire and undergo eye examination and lensometry. Then they underwent slit-lamp examinations and pictures were taken of the lens and fundus. People with suspected visual impairment were referred to an ophthalmology clinic. The data are processed and a four-level quality check is performed on each block. The most common visual impairment is cataracts. This study's most important aim is to evaluate the effect of local environmental and ethnic factors on eye diseases in this specific population.

945. Federated learning via over-the-air computation in IRS-assisted UAV communications.

Sci Rep

2023 May 17

Li R, Zhu L, Zhang G

946. Face-to-face more important than digital communication for mental health during the pandemic.

Sci Rep

2023 May 17

Stieger S, Lewetz D, Willinger D.

947. Blink-To-Live eye-based communication system for users with speech impairments.

Sci Rep

2023 May 17

Ezzat M, Maged M, Gamal Y

948. Gender specific factors contributing to cognitive resilience in APOE ɛ4 positive older adults in a population-based sample.

Sci Rep

2023 May 17

Zheng L, Eramudugolla R, Cherbuin N

949. Underweight and risk of fractures in adults over 40 years using the nationwide claims database.

Sci Rep

2023 May 17

Park SM(#), Park J(#), Han S

950. Association of endometriosis with genital human papillomavirus infection in US women: a national population-based study.

Sci Rep

2023 May 17

Hong YS(#), Park J(#), Kim H.

951. Genome-wide analysis of sex-specific differences in the mother-child PELAGIE cohort exposed to organophosphate metabolites.

Sci Rep

2023 May 17

Capriati M(#), Hao C(#), D'Cruz SC(#)

In recent decades, the detrimental effects of environmental contaminants on human health have become a serious public concern. Organophosphate (OP) pesticides are widely used in agriculture, and the negative impacts of OP and its metabolites on human health have been demonstrated. We hypothesized that exposure to OPs during pregnancy could impose damaging effects on the fetus by affecting various processes. We analyzed sex-specific epigenetic responses in the placenta samples obtained from the mother-child PELAGIE cohort. We assayed the telomere length and mitochondrial copy numbers using genomic DNA. We analyzed H3K4me3 by using chromatin immunoprecipitation followed by qPCR (ChIP‒qPCR) and high-throughput sequencing (ChIP-seq). The human study was confirmed with mouse placenta tissue analysis. Our study revealed a higher susceptibility of male placentas to OP exposure. Specifically, we observed telomere length shortening and an increase in γH2AX levels, a DNA damage marker. We detected lower histone H3K9me3 occupancy at telomeres in diethylphosphate (DE)-exposed male placentas than in nonexposed placentas. We found an increase in H3K4me3 occupancy at the promoters of thyroid hormone receptor alpha (THRA), 8-oxoguanine DNA glycosylase (OGG1) and insulin-like growth factor (IGF2) in DE-exposed female placentas. H3K4me3 occupancy at PPARG was increased in both male and female placentas exposed to dimethylphosphate (DM). The genome-wide sequencing of selected samples revealed sex-specific differences induced by DE exposure. Specifically, we found alterations in H3K4me3 in genes related to the immune system in female placenta samples. In DE-exposed male placentas, a decrease in H3K4me3 occupancy at development-related, collagen and angiogenesis-related genes was observed. Finally, we observed a high number of NANOG and PRDM6 binding sites in regions with altered histone occupancy, suggesting that the effects were possibly mediated via these factors. Our data suggest that in utero exposure to organophosphate metabolites affects normal placental development and could potentially impact late childhood.

952. General anesthesia with propofol during oocyte retrieval and in vitro fertilization outcomes: retrospective cohort study.

Sci Rep

2023 May 17

Haikin Herzberger E(#), Levy O(#), Sun B

953. Metal chalcogenides (CuS or MoS(2))-modified TiO(2) as highly efficient bifunctional photocatalyst nanocomposites for green H(2) generation and dye degradation.

Sci Rep

2023 May 17

El-Gendy RA, El-Bery HM, Farrag M

954. Detection of dengue virus infection in children presenting with fever in Hawassa, southern Ethiopia.

Sci Rep

2023 May 17

Shimelis T, Mulu A, Mengesha M

955. Uncertainties surrounding the oldest fossil record of diatoms.

Sci Rep

2023 May 17

Bryłka K, Alverson AJ, Pickering RA

956. A holistic and proactive approach to forecasting cyber threats.

Sci Rep

2023 May 17

Almahmoud Z, Yoo PD, Alhussein O

957. Impact of vitamin D in children with chronic tonsillitis (immunohistochemical study of CD68 polarisation and proinflammatory cytokines estimation).

Sci Rep

2023 May 17

Abu-Elnasr Awwad A, Hasan RA, Hablas MGA

958. Iron functionalized silica particles as an ingenious sorbent for removal of fluoride from water.

Sci Rep

2023 May 17

Kiprono P, Kiptoo J, Nyawade E

959. Bioaccumulation and biomagnifications of toxic metals in tissues of loggerhead turtles (Caretta caretta) from the Mediterranean Sea coast, Egypt.

Sci Rep

2023 May 17

Abdallah MAM.

960. Urban structure reinforces attitudes towards tsunami evacuation.

Sci Rep

2023 May 17

Makinoshima F, Oishi Y, Imamura F.

961. Research on spatial and temporal differences of carbon emissions and influencing factors in eight economic regions of China based on LMDI model.

Sci Rep

2023 May 17

Jiang P, Gong X, Yang Y

962. Multi-sample/multi-nucleus parallel polarization and monitoring enabled by a fluid path technology compatible cryogenic probe for dissolution dynamic nuclear polarization.

Sci Rep

2023 May 17

Lê TP, Hyacinthe JN, Capozzi A.

963. The impact of affective states and traits on perceptual stability during binocular rivalry.

Sci Rep

2023 May 17

Kraus N, Hesselmann G.

964. CuONPs/MWCNTs/carbon paste modified electrode for determination of tramadol: theoretical and experimental investigation.

Sci Rep

2023 May 17

Razavi R, Amiri M, Divsalar K

965. SIRT6-PAI-1 axis is a promising therapeutic target in aging-related bone metabolic disruption.

Sci Rep

2023 May 17

Aobulikasimu A(#), Liu T(#), Piao J

966. Development of a deep learning system to detect glaucoma using macular vertical optical coherence tomography scans of myopic eyes.

Sci Rep

2023 May 17

Kim JA(#), Yoon H(#), Lee D

967. Characterizing amblyopic perception under non-rivalrous viewing conditions.

Sci Rep

2023 May 17

Meier K, Tarczy-Hornoch K, Boynton GM

968. Genetic predictors of cultural values variation between societies.

Sci Rep

2023 May 17

Marcus J, Cetin E.

969. Determination, measurement, and validation of maximal aerobic speed.

Sci Rep

2023 May 17

Balasekaran G, Loh MK, Boey P

This study determined Maximal Aerobic Speed (MAS) at a speed that utilizes maximal aerobic and minimal anaerobic contributions. This method of determining MAS was compared between endurance (ET) and sprint (ST) trained athletes. Nineteen and 21 healthy participants were selected for the determination and validation of MAS respectively. All athletes completed five exercise sessions in the laboratory. Participants validating MAS also ran an all-out 5000 m at the track. Oxygen uptake at MAS was at 96.09 ± 2.51% maximal oxygen consumption ([Formula: see text]). MAS had a significantly higher correlation with velocity at lactate threshold (vLT), critical speed, 5000 m, time-to-exhaustion velocity at delta 50 in addition to 5% velocity at [Formula: see text] (TlimυΔ50 + 5%v[Formula: see text]), and Vsub%95 (υΔ50 or υΔ50 + 5%v[Formula: see text]) compared with v[Formula: see text], and predicted 5000 m speed (R2 = 0.90, p < 0.001) and vLT (R2 = 0.96, p < 0.001). ET athletes achieved significantly higher MAS (16.07 ± 1.58 km·h-1 vs. 12.77 ± 0.81 km·h-1, p ≤ 0.001) and maximal aerobic energy (EMAS) (52.87 ± 5.35 ml·kg-1·min-1 vs. 46.42 ± 3.38 ml·kg-1·min-1, p = 0.005) and significantly shorter duration at MAS (ET: 678.59 ± 165.44 s; ST: 840.28 ± 164.97 s, p = 0.039). ST athletes had significantly higher maximal speed (35.21 ± 1.90 km·h-1, p < 0.001) at a significantly longer distance (41.05 ± 3.14 m, p = 0.003) in the 50 m sprint run test. Significant differences were also observed in 50 m sprint performance (p < 0.001), and peak post-exercise blood lactate (p = 0.005). This study demonstrates that MAS is more accurate at a percentage of v[Formula: see text] than at v[Formula: see text]. The accurate calculation of MAS can be used to predict running performances with lower errors (Running Energy Reserve Index Paper).

970. A muti-informant national survey on the impact of COVID-19 on mental health symptoms of parent-child dyads in Canada.

Sci Rep

2023 May 17

Leigh JP(#), Moss SJ(#), Sriskandarajah C

The COVID-19 pandemic negatively impacted the mental health of children, youth, and their families which must be addressed and prevented in future public health crises. Our objective was to measure how self-reported mental health symptoms of children/youth and their parents evolved during COVID-19 and to identify associated factors for children/youth and their parents including sources accessed for information on mental health. We conducted a nationally representative, multi-informant cross-sectional survey administered online to collect data from April to May 2022 across 10 Canadian provinces among dyads of children (11-14 years) or youth (15-18 years) and a parent (> 18 years). Self-report questions on mental health were based on The Partnership for Maternal, Newborn & Child Health and the World Health Organization of the United Nations H6+ Technical Working Group on Adolescent Health and Well-Being consensus framework and the Coronavirus Health and Impact Survey. McNemar's test and the test of homogeneity of stratum effects were used to assess differences between children-parent and youth-parent dyads, and interaction by stratification factors, respectively. Among 933 dyads (N = 1866), 349 (37.4%) parents were aged 35-44 years and 485 (52.0%) parents were women; 227 (47.0%) children and 204 (45.3%) youth were girls; 174 (18.6%) dyads had resided in Canada < 10 years. Anxiety and irritability were reported most frequently among child (44, 9.1%; 37, 7.7%) and parent (82, 17.0%; 67, 13.9%) dyads, as well as among youth (44, 9.8%; 35, 7.8%) and parent (68, 15.1%; 49, 10.9%) dyads; children and youth were significantly less likely to report worsened anxiety (p < 0.001, p = 0.006, respectively) or inattention (p < 0.001, p = 0.028, respectively) compared to parents. Dyads who reported financial or housing instability or identified as living with a disability more frequently reported worsened mental health. Children (96, 57.1%), youth (113, 62.5%), and their parents (253, 62.5%; 239, 62.6%, respectively) most frequently accessed the internet for mental health information. This cross-national survey contextualizes pandemic-related changes to self-reported mental health symptoms of children, youth, and families.

971. Apoptotic gene loss in Cnidaria is associated with transition to parasitism.

Sci Rep

2023 May 17

Neverov AM, Panchin AY, Mikhailov KV

972. Mean amplitude of low frequency fluctuations measured by fMRI at 11.7 T in the aging brain of mouse lemur primate.

Sci Rep

2023 May 17

Garin CM, Dhenain M.

973. A Deep Q-Network based hand gesture recognition system for control of robotic platforms.

Sci Rep

2023 May 17

Cruz PJ(#), Vásconez JP(#), Romero R(#)

Hand gesture recognition (HGR) based on electromyography signals (EMGs) and inertial measurement unit signals (IMUs) has been investigated for human-machine applications in the last few years. The information obtained from the HGR systems has the potential to be helpful to control machines such as video games, vehicles, and even robots. Therefore, the key idea of the HGR system is to identify the moment in which a hand gesture was performed and it's class. Several human-machine state-of-the-art approaches use supervised machine learning (ML) techniques for the HGR system. However, the use of reinforcement learning (RL) approaches to build HGR systems for human-machine interfaces is still an open problem. This work presents a reinforcement learning (RL) approach to classify EMG-IMU signals obtained using a Myo Armband sensor. For this, we create an agent based on the Deep Q-learning algorithm (DQN) to learn a policy from online experiences to classify EMG-IMU signals. The HGR proposed system accuracy reaches up to [Formula: see text] and [Formula: see text] for classification and recognition respectively, with an average inference time per window observation of 20 ms. and we also demonstrate that our method outperforms other approaches in the literature. Then, we test the HGR system to control two different robotic platforms. The first is a three-degrees-of-freedom (DOF) tandem helicopter test bench, and the second is a virtual six-degree-of-freedom (DOF) UR5 robot. We employ the designed hand gesture recognition (HGR) system and the inertial measurement unit (IMU) integrated into the Myo sensor to command and control the motion of both platforms. The movement of the helicopter test bench and the UR5 robot is controlled under a PID controller scheme. Experimental results show the effectiveness of using the proposed HGR system based on DQN for controlling both platforms with a fast and accurate response.

974. Prognostic and immunological role of FDX1 in pan-cancer: an in-silico analysis.

Sci Rep

2023 May 16

Liu Z, Miao J.

Previous research has demonstrated that ferredoxin 1 (FDX1) contributes to the accumulation of toxic lipoylated dihydrolipoamide S-acetyltransferase (DLAT) and results in cuproptotic cell death. However, the role that FDX1 plays in human cancer prognosis and immunology is still not well understood. The original data was obtained from TCGA and GEO databases and integrated using R 4.1.0. The TIMER2.0, GEPIA, and BioGPS databases were used to explore FDX1 expression. The impact of FDX1 on prognosis was analyzed using the GEPIA and Kaplan-Meier Plotter databases. External validation will be performed using the PrognoScan database. FDX1 expression in different immune and molecular subtypes of human cancers was evaluated using the TISIDB database. The correlation between FDX1 expression and immune checkpoints (ICP), microsatellite instability (MSI), and tumor mutational burden (TMB) in human cancers was analyzed using R 4.1.0. The TIMER2.0 and GEPIA databases were used to study the relationship between FDX1 expression and tumor-infiltrating immune cells. With the c-BioPortal database, we investigated the genomic alterations of FDX1. Pathway analysis and assessment of the sensitivity potential of FDX1-related drugs were also performed. Using the UALCAN database, we analyzed the differential expression of FDX1 in KIRC (kidney renal clear cell carcinoma) with different clinical features. Coexpression networks of FDX1 were analyzed using LinkedOmics. In general, FDX1 was expressed differently in different types of cancer in humans. Expression of FDX1 was strongly correlated with patient prognosis, ICP, MSI, and TMB. FDX1 was also participated in immune regulation and the tumor microenvironment. Coexpression networks of FDX1 were primarily involved in oxidative phosphorylation regulation. Pathway analysis revealed that the expression of FDX1 was correlated to cancer-related and immune-related pathways. FDX1 has the potential to serve as a biomarker for pan-cancer prognosis and immunology, as well as a novel target for tumor therapy.

975. Predicting the potential geographical distribution of onion thrips, Thrips tabaci in India based on climate change projections using MaxEnt.

Sci Rep

2023 May 16

Karuppaiah V, Maruthadurai R, Das B

Onion thrips, Thrips tabaci Lindeman, an economically important onion pest in India, poses a severe threat to the domestic and export supply of onions. Therefore, it is important to study the distribution of this pest in order to assess the possible crop loss, which it may inflict if not managed in time. In this study, MaxEnt was used to analyze the potential distribution of T. tabaci in India and predict the changes in the suitable areas for onion thrips under two scenarios, SSP126 and SSP585. The area under the receiver operating characteristic curve values of 0.993 and 0.989 for training and testing demonstrated excellent model accuracy. The true skill statistic value of 0.944 and 0.921, and the continuous Boyce index of 0.964 and 0.889 for training and testing, also showed higher model accuracy. Annual Mean Temperature (bio1), Annual Precipitation (bio12) and Precipitation Seasonality (bio15) are the main variables that determined the potential distribution of T. tabaci, with the suitable range of 22-28 °C; 300-1000 mm and 70-160, respectively. T. tabaci is distributed mainly in India's central and southern states, with 1.17 × 106 km2, covering 36.4% of land area under the current scenario. Multimodal ensembles show that under a low emission scenario (SSP126), low, moderate and optimum suitable areas of T. tabaci is likely to increase, while highly suitable areas would decrease by 17.4% in 2050 20.9% in 2070. Whereas, under the high emission scenario (SSP585), the high suitability is likely to contract by 24.2% and 51.7% for 2050 and 2070, respectively. According to the prediction of the BCC-CSM2-MR, CanESM5, CNRM-CM6-1 and MIROC6 model, the highly suitable area for T. tabaci would likely contract under both SSP126 and SSP585. This study detailed the potential future habitable area for T. tabaci in India, which could help monitor and devise efficient management strategies for this destructive pest.

976. Association of rural living with COPD-related hospitalizations and deaths in US veterans.

Sci Rep

2023 May 16

Fortis S, Gao Y, Baldomero AK

977. Action spectrum for reorientations in bacteriorhodopsin of purple membrane in suspension.

Sci Rep

2023 May 16

Mostafa HIA.

978. Direct detection and identification of periprosthetic joint infection pathogens by metagenomic next-generation sequencing.

Sci Rep

2023 May 16

Hao L, Wen P, Song W

979. Fault detection of gearbox by multivariate extended variational mode decomposition-based time-frequency images and incremental RVM algorithm.

Sci Rep

2023 May 16

Nao S, Wang Y.

980. Single cell profiling at the maternal-fetal interface reveals a deficiency of PD-L1(+) non-immune cells in human spontaneous preterm labor.

Sci Rep

2023 May 16

Liu X, Aneas I, Sakabe N

981. Novel characteristics for immunophenotype, FISH pattern and molecular cytogenetics in synovial sarcoma.

Sci Rep

2023 May 16

Zhong LL(#), Huang GX(#), Xian LY

As a rare and highly aggressive soft tissue sarcoma, the new immunophenotype, atypical FISH pattern and relevant molecular cytogenetics of synovial sarcoma (SS) remain less known, although it is characteristically represented by a pathognomonic chromosomal translocation t (X; 18) (p11.2; q11.2). Methodologically, the morphology was retrospectively analysed by using H&E staining, and immunohistochemical features were investigated by using markers that have been recently applied in other soft tissue tumors. Moreover, FISH signals for SS18 and EWSR-1 break-apart probes were examined. Finally, cytogenetic characteristics were analysed via RT-PCR and Sanger sequencing. Consequently, nine out of thirteen cases that were histologically highly suspected as SS were finally identified as SS via molecular analysis. Histologically, nine SS cases were divided into monophasic fibrous SS (4/9), biphasic SS (4/9) and poorly differentiated SS (1/9). Immunohistochemically, SOX-2 immunostaining was positive in eight cases (8/9) and PAX-7 immunostaining was diffusely positive in the epithelial component of biphasic SS (4/4). Nine cases showed negative immunostaining for NKX3.1 and reduced or absent immunostaining for INI-1. Eight cases showed typically positive FISH signalling for the SS18 break-apart probe, whereas one case exhibited an atypical FISH pattern (complete loss of green signalling, case 2). Furthermore, the SS18-SSX1 and SS18-SSX2 fusion genes were identified in seven cases and two cases, respectively. The fusion site in 8 out of 9 cases was common in the literature, whereas the fusion site in case 2 was involved in exon 10 codon 404 in SS18 and exon 7 codon 119 in SSX1 (which has not been previously reported), which notably corresponded to the complete loss of green signalling in the FISH pattern. Additionally, FISH analysis of the EWSR-1 gene in nine SS cases demonstrated aberrant signalling in three cases that were recognized as a monoallelic loss of EWSR-1 (1/9), an amplification of EWSR-1 (1/9) and a translocation of EWSR-1 (1/9). In conclusion, SS18-SSX fusion gene sequencing is obligatory for a precise diagnosis of SS when dealing with a confusing immunophenotype and atypical or aberrant FISH signalling for SS18 and EWSR-1 detection.

982. Impacts of algae supplements (Arthrospira & Chlorella) on growth, nutrient variables, intestinal efficacy, and antioxidants in New Zealand white rabbits.

Sci Rep

2023 May 16

El Basuini MF, Khattab AAA, Hafsa SHA

983. Diabetes and obesity and risk of pyogenic liver abscess.

Sci Rep

2023 May 16

Wang JL, Hsu CR, Wu CY

984. A retrospective analysis of clinical features of patients hospitalized with SARS-CoV-2 Omicron variants BA.1 and BA.2.

Sci Rep

2023 May 16

Groza C, Totschnig D, Wenisch C

985. Seasonal variation in δ(13)C of Pinus. yunnanensis and Pinus. armandii at different stand ages.

Sci Rep

2023 May 16

Liu Y, Wu J, Wu D

986. Regional long-term analysis of dietary isotopes in Neolithic southeastern Italy: new patterns and research directions.

Sci Rep

2023 May 16

Tafuri MA, Soncin S, Panella S

987. Discovery of interconnected causal drivers of COVID-19 vaccination intentions in the US using a causal Bayesian network.

Sci Rep

2023 May 16

Fung H, Sgaier SK, Huang VS.

988. High-resolution microbiome analysis reveals exclusionary Klebsiella species competition in preterm infants at risk for necrotizing enterocolitis.

Sci Rep

2023 May 16

Coleman S, Unterhauser K, Rezaul K

989. Design of a water-soluble chitosan-based polymer with antioxidant and chelating properties for labile iron extraction.

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2023 May 16

Grange C, Aigle A, Ehrlich V

990. Foot plantar pressure and centre of pressure trajectory differ between straight and turning steps in infants.

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2023 May 16

Price C, Montagnani E, Nester C

991. Modeling of H(2)S solubility in ionic liquids: comparison of white-box machine learning, deep learning and ensemble learning approaches.

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2023 May 16

Mousavi SP, Nakhaei-Kohani R, Atashrouz S

In the context of gas processing and carbon sequestration, an adequate understanding of the solubility of acid gases in ionic liquids (ILs) under various thermodynamic circumstances is crucial. A poisonous, combustible, and acidic gas that can cause environmental damage is hydrogen sulfide (H2S). ILs are good choices for appropriate solvents in gas separation procedures. In this work, a variety of machine learning techniques, such as white-box machine learning, deep learning, and ensemble learning, were established to determine the solubility of H2S in ILs. The white-box models are group method of data handling (GMDH) and genetic programming (GP), the deep learning approach is deep belief network (DBN) and extreme gradient boosting (XGBoost) was selected as an ensemble approach. The models were established utilizing an extensive database with 1516 data points on the H2S solubility in 37 ILs throughout an extensive pressure and temperature range. Seven input variables, including temperature (T), pressure (P), two critical variables such as temperature (Tc) and pressure (Pc), acentric factor (ω), boiling temperature (Tb), and molecular weight (Mw), were used in these models; the output was the solubility of H2S. The findings show that the XGBoost model, with statistical parameters such as an average absolute percent relative error (AAPRE) of 1.14%, root mean square error (RMSE) of 0.002, standard deviation (SD) of 0.01, and a determination coefficient (R2) of 0.99, provides more precise calculations for H2S solubility in ILs. The sensitivity assessment demonstrated that temperature and pressure had the highest negative and highest positive affect on the H2S solubility in ILs, respectively. The Taylor diagram, cumulative frequency plot, cross-plot, and error bar all demonstrated the high effectiveness, accuracy, and reality of the XGBoost approach for predicting the H2S solubility in various ILs. The leverage analysis shows that the majority of the data points are experimentally reliable and just a small number of data points are found beyond the application domain of the XGBoost paradigm. Beyond these statistical results, some chemical structure effects were evaluated. First, it was shown that the lengthening of the cation alkyl chain enhances the H2S solubility in ILs. As another chemical structure effect, it was shown that higher fluorine content in anion leads to higher solubility in ILs. These phenomena were confirmed by experimental data and the model results. Connecting solubility data to the chemical structure of ILs, the results of this study can further assist to find appropriate ILs for specialized processes (based on the process conditions) as solvents for H2S.

992. Computational drug repurposing of Akt-1 allosteric inhibitors for non-small cell lung cancer.

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2023 May 16

Baby K, Maity S, Mehta CH

993. Differences in gene regulation by TLR3 and IPS-1 signaling in murine corneal epithelial cells.

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2023 May 16

Komai S, Ueta M, Nishigaki H

994. Life cycle environmental impact assessment for battery-powered electric vehicles at the global and regional levels.

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2023 May 16

Zhang H(#), Xue B(#), Li S

995. Dual quantum cascade lasers for noninvasive glucose detection using photoacoustic spectroscopy.

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2023 May 16

Aloraynan A, Rassel S, Kaysir MR

996. A novel deep learning approach for typhoon-induced storm surge modeling through efficient emulation of wind and pressure fields.

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2023 May 16

Mulia IE, Ueda N, Miyoshi T

997. AgSCN as a new hole transporting material for inverted perovskite solar cells.

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2023 May 16

Elseman AM.

998. Cigarette smoke increases susceptibility of alveolar macrophages to SARS-CoV-2 infection through inducing reactive oxygen species-upregulated angiotensin-converting enzyme 2 expression.

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2023 May 16

Kuo CW, Su PL, Huang TH

999. A multicenter feasibility study on implementing a brief mindful breathing exercise into regular university courses.

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2023 May 16

Konrad AC, Engert V, Albrecht R

1000. Cutaneous body image in patients with hidradenitis suppurativa: a hospital-based cross-sectional study.

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2023 May 16

Koumaki D, Rovithi E, Solia Apokidou E

Hidradenitis suppurativa (HS) has been linked with body image (BI) impairment and reduced quality of life (QoL). We sought to evaluate the associations between Cutaneous Body Image Scale (CBIS) and disease severity in HS patients.Between July 2020 and January 2022, a cross-sectional study was carried out including consecutive HS patients above the age of 16 who attended a Tertiary Referral Hospital in Greece. Disease Severity was graded with the Hurley stage, HS-Physician's Global Assessment (HS-PGA) scale, and the Modified Sartorius scale (MSS). Patients completed at their first visit ten survey instruments including Patients' Severity of disease, pain and pruritus scale, CBIS, Multidimensional Body-Self Relations Questionnaire (MBSRQ) including 5 subscales: Appearance Evaluation (AE), Appearance Orientation (AO), Body Areas Satisfaction Scale (BASS), Overweight Preoccupation (OWP), and Self Classified Weight (SCW) , Dermatology Quality of Life Index (DLQI), Skindex-16, EQ5D 5L, EQ- visual analogue scale (VAS), PHQ9, and GAD7. In total, 70 HS patients above 16 years old participated, mean [SD] age, 34.44 [11.64] years; 49/70 (70%) males and 21/70 (30%) females. Mean ± SD CBI, DLQI, Skindex-16 total, EQ-5D-5L, EQ VAS, PHQ9 and GAD7 were 5.59 ± 1.58, 11.70 ± 8.88, 52.90 ± 27.75, 0.75 ± 0.21, 62.48 ± 21.12, 7.64 ± 5.56, 7.87 ± 5.23 respectively. Moderate to severe CBI dissatisfaction was reported by 36/70 (51.42%) patients. CBI was correlated with appearance evaluation (AE) (p < 0.01, r = 0.544), body areas satisfaction (BASS) (p < 0.01, r = 0.481), and overweight preoccupation subscale (OWPS) (p < 0.01, r = - 0.267), and Skindex-16 (p < 0.01, r = - 0.288). HS patients with affected genital areas scored higher in disease patient's severity score (p = 0.015), and male patients scored higher in Skindex-16 than females(p < 0.01). Our study found that the mean of CBI in HS patients was 5.59 ± SD 1.58. Predictors for CBI dissatisfaction were low scores of MBSRQ Appearance Evaluation (AE) and Body Areas Satisfaction Subscale (BASS).

1001. Effectiveness of a telerehabilitation intervention using ReCOVery APP of long COVID patients: a randomized, 3-month follow-up clinical trial.

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2023 May 16

Samper-Pardo M, León-Herrera S, Oliván-Blázquez B

1002. SOC stocks prediction on the basis of spatial and temporal variation in soil properties by using partial least square regression.

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2023 May 16

Usman J, Begum S.

1003. The association between conjunctival and scleral thickness and ocular surface ultraviolet autofluorescence.

Sci Rep

2023 May 16

Rajasingam P(#), Shaw A(#), Davis B

1004. Financial inclusion helps rural households address climate risk.

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2023 May 16

Chhatre A, Deuskar P, Mohib J

1005. Assessment of efficacy and safety of advanced endoscopic irreversible electroporation catheter in the esophagus.

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2023 May 16

Jeon HJ, Choi HS, Lee JM

1006. Differences in optic nerve head structure between acute angle-closure glaucoma and open-angle glaucoma.

Sci Rep

2023 May 16

Kong JH, Park SP, Na KI.

1007. Erosion-inhibiting potential of the stannous fluoride-enriched CPP-ACP complex in vitro.

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2023 May 16

Al Saady D, Hall C, Edwards S

1008. Improving video surveillance systems in banks using deep learning techniques.

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2023 May 16

Zahrawi M, Shaalan K.

1009. Spicy food intake predicts Alzheimer-related cognitive decline in older adults with low physical activity.

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2023 May 16

Hwang J, Choe YM, Suh GH

A plausible association exists among spicy food consumption, physical activity, and Alzheimer's disease (AD) or cognitive decline, but it remains poorly investigated. We aimed to examined the association between spicy food and AD-related memory decline or global cognitive decline in older adults under the moderating effect of physical activity. Total 196 non-demented older adults were included. Participants underwent comprehensive dietary and clinical assessments including spicy food intake, AD-related memory, global cognition, and physical activity. The strength of spicy food was stratified into three categories: 'not spicy' (reference), 'low spiciness', and 'high spiciness'. Multiple linear regression analyses were performed to examine the relationships between spicy level and cognition. The spicy level was the independent variable in each analysis; it was entered as a stratified categorical variable using the three categories. We found a significant association between a high level of spiciness in food and decreased memory ([Formula: see text] - 0.167, p < 0.001) or global cognition ([Formula: see text] - 0.122, p = 0.027), but not non-memory cognition. To explore the moderating effects of age, sex, apolipoprotein E ε4 allele-positivity, vascular risk score, body mass index, and physical activity on the associations between spicy level and memory or global cognition, the same regression analyses were repeated including two-way interaction terms between the spicy level and each of the six variables as an additional independent variable. An interactive effect was detected between a high level of spiciness in food and physical activity on the memory ([Formula: see text] 0.209, p = 0.029) or global cognition ([Formula: see text] 0.336, p = 0.001). Subgroup analyses showed that the association between a high level of spiciness in food and a lower memory ([Formula: see text] - 0.254, p < 0.001) and global score ([Formula: see text] - 0.222, p = 0.002) was present only in older adults with low physical activity, but not in older adults with high physical activity. Our findings suggest that spicy food intake is predictive of AD-related cognitive decline, i.e., episodic memory; this relationship is worsened by physically inactive lifestyle.

1010. Role of extreme vertex design approach on the mechanical and morphological behaviour of residual soil composite.

Sci Rep

2023 May 16

Attah IC, Alaneme GU, Etim RK

1011. Posterior hippocampal CA2/3 volume is associated with autobiographical memory recall ability in lower performing individuals.

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2023 May 16

Clark IA, Dalton MA, Maguire EA.

1012. Effect of viscosity of experimental universal adhesive on bond strength to dentin prepared with Er:YAG laser.

Sci Rep

2023 May 16

Kamitsu T, Shimomura-Kuroki J, Shinkai K.

1013. The impact of floating photovoltaic power plants on lake water temperature and stratification.

Sci Rep

2023 May 16

Ilgen K, Schindler D, Wieland S

1014. DNA methylation variations and epigenetic aging in telomere biology disorders.

Sci Rep

2023 May 16

Carlund O, Norberg A, Osterman P

1015. Supervised deep learning with vision transformer predicts delirium using limited lead EEG.

Sci Rep

2023 May 16

Mulkey MA, Huang H, Albanese T

1016. Defining the filarial N-glycoproteome by glycosite mapping in the human parasitic nematode Brugia malayi.

Sci Rep

2023 May 16

Mersha FB, McClung CM, Chen M

1017. The effect of chronic low back pain on postural control during quiet standing: A meta-analysis.

Sci Rep

2023 May 16

Park J, Nguyen VQ, Ho RLM

1018. Classification tasks using input driven nonlinear magnetization dynamics in spin Hall oscillator.

Sci Rep

2023 May 16

Mohan JR, Mathew AJ, Nishimura K

1019. Experimental investigation on the hazard of geyser created by an entrapped air release in baffle-drop shafts.

Sci Rep

2023 May 16

Yang Q, Yang Q.

1020. Mitogenomic phylogenetic analyses provide novel insights into the taxonomic problems of several hesperiid taxa (Lepidoptera: Hesperiidae).

Sci Rep

2023 May 16

Zhu L(#), Han Y(#), Hou Y(#)

1021. Effect of municipal biowaste derived biostimulant on nitrogen fate in the plant-soil system during lettuce cultivation.

Sci Rep

2023 May 16

Fragalà F, Puglisi I, Padoan E

1022. Glucagon-like peptide-1 facilitates cerebellar parallel fiber glutamate release through PKA signaling in mice in vitro.

Sci Rep

2023 May 16

Wang XY(#), Liu Y(#), Cao LX

1023. Generative and discriminative training of Boltzmann machine through quantum annealing.

Sci Rep

2023 May 16

Srivastava S, Sundararaghavan V.

A hybrid quantum-classical method for learning Boltzmann machines (BM) for a generative and discriminative task is presented. BM are undirected graphs with a network of visible and hidden nodes where the former is used as the reading site. In contrast, the latter is used to manipulate visible states' probability. In Generative BM, the samples of visible data imitate the probability distribution of a given data set. In contrast, the visible sites of discriminative BM are treated as Input/Output (I/O) reading sites where the conditional probability of output state is optimized for a given set of input states. The cost function for learning BM is defined as a weighted sum of Kullback-Leibler (KL) divergence and Negative conditional Log-likelihood (NCLL), adjusted using a hyper-parameter. Here, the KL Divergence is the cost for generative learning, and NCLL is the cost for discriminative learning. A Stochastic Newton-Raphson optimization scheme is presented. The gradients and the Hessians are approximated using direct samples of BM obtained through quantum annealing. Quantum annealers are hardware representing the physics of the Ising model that operates on low but finite temperatures. This temperature affects the probability distribution of the BM; however, its value is unknown. Previous efforts have focused on estimating this unknown temperature through regression of theoretical Boltzmann energies of sampled states with the probability of states sampled by the actual hardware. These approaches assume that the control parameter change does not affect the system temperature; however, this is usually untrue. Instead of using energies, the probability distribution of samples is employed to estimate the optimal parameter set, ensuring that the optimal set can be obtained from a single set of samples. The KL divergence and NCLL are optimized for the system temperature, and the result is used to rescale the control parameter set. The performance of this approach, as tested against the theoretically expected distributions, shows promising results for Boltzmann training on quantum annealers.

1024. Comparative impact of streptozotocin on altering normal glucose homeostasis in diabetic rats compared to normoglycemic rats.

Sci Rep

2023 May 16

Rehman HU, Ullah K, Rasool A

Diabetes mellitus is a syndrome and an endocrine disorder, primarily considered as a loss of glucose homeostasis because of the insulin action and/or secretion or both. Currently there are more than 150 million people in the world affected by diabetes mellitus with a higher share of Asian and European countries. The current study aimed to investigate the comparative altering properties of streptozotocin (STZ), based on up-turn and down-turn configuration of biochemical, toxicological and hematological parameters in comparison with normoglycemic male albino rats. This comparative study was conducted among normoglycemic and STZ based induced-type 2 diabetic male albino rats groups. The male albino rats were intra-peritoneally injected with STZ with the dose rate of 65 mg/kg body weight for one time to developed type 2 diabetic model. Biochemical (blood glucose, uric acid, urea and creatinine), toxicological (AST, ALT and ALP) and hematological parameters (red and white blood cells) and their functional indices were evaluated in type 2 diabetic induced group along with normoglycemic rats. The STZ based induced- type 2 diabetic rats showed statistically significance (p < 0.001) higher level in the blood glucose, alongwith the change in the levels of biochemical parameters including urea, uric acid, and creatinine. Toxicological parameters comprising AST, ALT and ALP were also shown significance (p < 0.001) as sufficient after experimental evaluation of biologically important parameter in STZ based induced-type 2 diabetic rats. Likewise, the red blood cells, white blood cells and their efficient components were exposed significantly insufficient after the injecting of STZ to induce the rats as type 2 diabetic. The results of the current study indicates the comparatively higher levels of variation among biochemical, toxicological and hematological parameters in STZ based Induced-type 2 diabetic model as compared to normoglycemic group.

1025. Sympathetic modulation of hindlimb muscle contractility is altered in aged rats.

Sci Rep

2023 May 16

Hotta H, Iimura K, Watanabe N

Sci Rep

2023 May 15

Zhang Y, Li J, Yang L.

1027. Ticks harbor and excrete chronic wasting disease prions.

Sci Rep

2023 May 15

Inzalaco HN, Bravo-Risi F, Morales R

1028. Numerical study of hydrothermal and mass aspects in MHD driven Sisko-nanofluid flow including optimization analysis using response surface method.

Sci Rep

2023 May 15

Wang X, Rasool G, Shafiq A

1029. The risk factors of postoperative nausea and vomiting in patients undergoing laparoscopic sleeve gastrectomy and laparoscopic distal gastrectomy: a propensity score matching analysis.

Sci Rep

2023 May 15

Chen P(#), Du R(#), Chang Z(#)

1030. Spatial ability and 3D model colour-coding affect anatomy performance: a cross-sectional and randomized trial.

Sci Rep

2023 May 15

Koh MY, Tan GJS, Mogali SR.

Photorealistic 3D models (PR3DM) have great potential to supplement anatomy education; however, there is evidence that realism can increase cognitive load and negatively impact anatomy learning, particularly in students with decreased spatial ability. These differing viewpoints have resulted in difficulty in incorporating PR3DM when designing anatomy courses. To determine the effects of spatial ability on anatomy learning and reported intrinsic cognitive load using a drawing assessment, and of PR3DM versus an Artistic colour-coded 3D model (A3DM) on extraneous cognitive load and learning performance. First-year medical students participated in a cross-sectional (Study 1) and a double-blind randomised control trial (Study 2). Pre-tests analysed participants' knowledge of anatomy of the heart (Study 1, N = 50) and liver (Study 2, N = 46). In Study 1, subjects were first divided equally using a mental rotations test (MRT) into low and high spatial ability groups. Participants memorised a 2D-labeled heart valve diagram and sketched it rotated 180°, before self-reporting their intrinsic cognitive load (ICL). For Study 2, participants studied a liver PR3DM or its corresponding A3DM with texture-homogenisation, followed by a liver anatomy post-test, and reported extraneous cognitive load (ECL). All participants reported no prior anatomy experience. Participants with low spatial ability (N = 25) had significantly lower heart drawing scores (p = 0.001) than those with high spatial ability (N = 25), despite no significant differences in reported ICL (p = 0.110). Males had significantly higher MRT scores than females (p = 0.011). Participants who studied the liver A3DM (N = 22) had significantly higher post-test scores than those who studied the liver PR3DM (N = 24) (p = 0.042), despite no significant differences in reported ECL (p = 0.720). This investigation demonstrated that increased spatial ability and colour-coding of 3D models are associated with improved anatomy performance without significant increase in cognitive load. The findings are important and provide useful insight into the influence of spatial ability and photorealistic and artistic 3D models on anatomy education, and their applicability to instructional and assessment design in anatomy.

1031. Targeted dream incubation at sleep onset increases post-sleep creative performance.

Sci Rep

2023 May 15

Horowitz AH(#), Esfahany K(#), Gálvez TV

1032. Edentulous disparities among geriatric population according to the sexual difference in South Korea: a nationwide population-based study.

Sci Rep

2023 May 15

Park HA, Shin SH, Ryu JI.

1033. From language models to large-scale food and biomedical knowledge graphs.

Sci Rep

2023 May 15

Cenikj G, Strojnik L, Angelski R

1034. Spatial and seasonal distribution of human schistosomiasis intermediate host snails and their interactions with other freshwater snails in 7 districts of KwaZulu-Natal province, South Africa.

Sci Rep

2023 May 15

Nwoko OE, Manyangadze T, Chimbari MJ.

1035. Golden ratio in venation patterns of dragonfly wings.

Sci Rep

2023 May 15

Lu K(#), Shen S(#), Miller LM

1036. Synthesis, in vitro inhibitor screening, structure-activity relationship, and molecular dynamic simulation studies of novel thioquinoline derivatives as potent α-glucosidase inhibitors.

Sci Rep

2023 May 15

Forozan R, Ghomi MK, Iraji A

1037. Neutrophil to high-density lipoprotein cholesterol ratio as the risk mark in patients with type 2 diabetes combined with acute coronary syndrome: a cross-sectional study.

Sci Rep

2023 May 15

Ren H(#), Zhu B(#), Zhao Z

Chronic inflammation and dyslipidemia are important risk factors in developing atherosclerotic cardiovascular disease, such as coronary heart disease. Acute coronary syndrome (ACS) is one of the most dangerous syndromes in coronary heart disease. Type 2 diabetes mellitus (T2DM) is considered equal to coronary heart disease owing to the high cardiac risk induced by chronic inflammation and dyslipidemia. The neutrophil to high-density lipoprotein cholesterol ratio (NHR) is a novel and straightforward marker that reflects inflammation and lipid metabolic disorder. However, few studies have been on the role of NHR in assessing the risk of ACS in T2DM patients. Here we analyzed NHR level in ACS patients with T2DM, exploring its predictive and diagnostic values. 211 hospitalized ACS patients with T2DM were recruited as the case group, and 168 hospitalized T2DM patients as the control group (all patients collected from 6/2020 to 12/2021 in Xiangya Hospital). Biochemical test results and echocardiograms, as well as demographic information such as age, BMI, diabetes mellitus, smoking, drinking, and history of hypertension, were recorded. Frequencies, percentages, means, and standard deviations were used to describe the data. The shapiro-Wilk test was used to assess the normality of the data. Normally distributed data were compared using the independent sample T-test, and non-normally distributed data were compared using Mann-Whitney U test. Correlation analysis was performed using the Spearman rank correlation test, and receiver operating characteristic (ROC) curve analysis and multivariable logistic regression analysis were performed by SPSS version 24.0 (SPSS Inc) and GraphPad Prism 9.0 (GraphPad Software Inc). p < 0.05 was considered significant. In the study population, NHR was higher in patients with T2DM combined with ACS than in T2DM patients without ACS (p < 0.001). After adjusting for BMI, alcohol consumption, and history of hypertension, multifactorial logistic regression analysis revealed that NHR is a risk factor for T2DM patients combined with ACS (OR 1.221, p = 0.0126). Correlation analysis on all ACS patients with T2DM showed that NHR level was positively correlated with cTnI (r = 0.437, p < 0.001), CK (r = 0.258, p = 0.001), CK-Mb (r = 0.447, p < 0.001), LDH (r = 384, p < 0.001), Mb (r = 0.320, p < 0.001), LA (r = 0.168, p = 0.042) and LV levels (r = 0.283, p = 0.001). And meanwhile, NHR level was negatively correlated with EF (r = - 0.327, p < 0.001) and FS levels (r = - 0.347, p < 0.001). ROC curve analysis showed that NHR ≧ 4.32 had a sensitivity of 65.45% and a specificity of 66.19% for predicting ACS in T2DM patients [area under the curve (AUC) = 0.722, p < 0.001]. Furthermore, in all ACS patients with T2DM, the diagnostic power of NHR was stronger in ST-segment elevated ACS patients (STE-ACS) than that in non-ST-segment elevated ACS patients (NSTE-ACS) (p < 0.001). With its convenience and effective character, NHR could be a potential and new marker for predicting the presence, progression, and severity of ACS in T2DM population.

1038. Third harmonic imaging contrast from tubular structures in the presence of index discontinuity.

Sci Rep

2023 May 15

Morizet J, Olivier N, Mahou P

1039. Lightweight aerial image object detection algorithm based on improved YOLOv5s.

Sci Rep

2023 May 15

Deng L, Bi L, Li H

1040. A critical assessment of nanoparticles enhanced phase change materials (NePCMs) for latent heat energy storage applications.

Sci Rep

2023 May 15

Amidu MA, Ali M, Alkaabi AK

Phase change material (PCM) laden with nanoparticles has been testified as a notable contender to increase the effectiveness of latent heat thermal energy storage (TES) units during charging and discharging modes. In this study, a numerical model is developed and implemented based on the coupling between an advanced two-phase model for the nanoparticles-enhanced PCM (NePCM) and the enthalpy-porosity formulation for the transient behavior of the phase change. Therefore, a porosity source term is added to the nanoparticles transport equation to account for the particles' frozen state in regions occupied by solid PCM. This two-phase model includes three main nanoparticles' slip mechanisms: Brownian diffusion, thermophoresis diffusion, and sedimentation. A two-dimensional model of a triplex tube heat exchanger is considered and different charging and discharging configurations are analyzed. Compared to pure PCM, results show a substantial heat transfer enhancement during the charging and discharging cycle in which a homogeneous distribution of nanoparticles is considered as the initial condition. For this case, the two-phase model predictions are superior to the ones obtained with the classical single-phase model. In the case of multi-cycle charging and discharging, a significant deterioration of the heat transfer rate is observed using the two-phase model while such assessment is senseless using the single-phase mixture model due to the physical assumptions upon which this model is formulated. The two-phase model results reveal that, for a NePCM with high nanoparticles concentration (> 1%), the melting performance during the second charging cycle is reduced by 50% compared to the first one. This performance degradation is attributed to a noteworthy non-homogeneous distribution of the nanoparticles at the beginning of the second charging cycle. The dominant nanoparticles migration mechanism, in this scenario, is the one resulting from sedimentation effects.

1041. Mediation of the mediolateral ground reaction force profile to maintain straight running among unilateral transfemoral amputees.

Sci Rep

2023 May 15

Tang YW, Murai A, Hobara H.

1042. Mechanical behavior and particle crushing of irregular granular material under high pressure using discrete element method.

Sci Rep

2023 May 15

Chen Q, Li Z, Dai Z

1043. Association of Molnupiravir and Nirmatrelvir-Ritonavir with reduced mortality and sepsis in hospitalized omicron patients: a territory-wide study.

Sci Rep

2023 May 15

Wai AK(#), Lee TT(#), Chan SC

This study evaluates the association between antivirals (Molnupiravir and Nirmatrelvir-Ritonavir) and all-cause and respiratory mortality and organ dysfunction among high-risk COVID-19 patients during an Omicron outbreak. Two cohorts, Nirmatrelvir-Ritonavir versus control and Molnupiravir versus control, were constructed with inverse probability treatment weighting to balance baseline characteristics. Cox proportional hazards models evaluated the association of their use with all-cause mortality, respiratory mortality, and all-cause sepsis (a composite of circulatory shock, respiratory failure, acute liver injury, coagulopathy, and acute liver impairment). Patients recruited were hospitalized and diagnosed with the COVID-19 Omicron variant between February 22, 2022 and April 15, 2022, and followed up until May 15, 2022. The study included 17,704 patients. There were 4.67 and 22.7 total mortalities per 1000 person-days in the Nirmatrelvir-Ritonavir and control groups respectively before adjustment (weighted incidence rate ratio, - 18.1 [95% CI - 23.0 to - 13.2]; hazard ratio, 0.18 [95% CI, 0.11-0.29]). There were 6.64 and 25.9 total mortalities per 1000 person-days in the Molnupiravir and control groups respectively before adjustment (weighted incidence rate ratio per 1000 person-days, - 19.3 [95% CI - 22.6 to - 15.9]; hazard ratio, 0.23 [95% CI 0.18-0.30]). In all-cause sepsis, there were 13.7 and 35.4 organ dysfunction events per 1000 person-days in the Nirmatrelvir-Ritonavir and control groups respectively before adjustment (weighted incidence rate ratio per 1000 person-days, - 21.7 [95% CI - 26.3 to - 17.1]; hazard ratio, 0.44 [95% CI 0.38-0.52]). There were 23.7 and 40.8 organ dysfunction events in the Molnupiravir and control groups respectively before adjustment (weighted incidence ratio per 1000 person-days, - 17.1 [95% CI, - 20.6 to - 13.6]; hazard ratio, 0.63 [95% CI 0.58-0.69]). Among COVID-19 hospitalized patients, use of either Nirmatrelvir-Ritonavir or Molnupiravir compared with no antiviral use was associated with a significantly lower incidence of 28-days all-cause and respiratory mortality and sepsis.

1044. Changes in the chemical compositions and biological properties of kombucha beverages made from black teas and pineapple peels and cores.

Sci Rep

2023 May 15

Phung LT, Kitwetcharoen H, Chamnipa N

Several raw materials have been used as partial supplements or entire replacements for the main ingredients of kombucha to improve the biological properties of the resulting kombucha beverage. This study used pineapple peels and cores (PPC), byproducts of pineapple processing, as alternative raw materials instead of sugar for kombucha production. Kombuchas were produced from fusions of black tea and PPC at different ratios, and their chemical profiles and biological properties, including antioxidant and antimicrobial activities, were determined and compared with the control kombucha without PPC supplementation. The results showed that PPC contained high amounts of beneficial substances, including sugars, polyphenols, organic acids, vitamins, and minerals. An analysis of the microbial community in a kombucha SCOBY (Symbiotic Cultures of Bacteria and Yeasts) using next-generation sequencing revealed that Acetobacter and Komagataeibacter were the most predominant acetic acid bacteria. Furthermore, Dekkera and Bacillus were also the prominent yeast and bacteria in the kombucha SCOBY. A comparative analysis was performed for kombucha products fermented using black tea and a fusion of black tea and PPC, and the results revealed that the kombucha made from the black tea and PPC infusion exhibited a higher total phenolic content and antioxidant activity than the control kombucha. The antimicrobial properties of the kombucha products made from black tea and the PPC infusion were also greater than those of the control. Several volatile compounds that contributed to the flavor, aroma, and beneficial health properties, such as esters, carboxylic acids, phenols, alcohols, aldehydes, and ketones, were detected in kombucha products made from a fusion of black tea and PPC. This study shows that PPC exhibits high potential as a supplement to the raw material infusion used with black tea for functional kombucha production.

1045. Causal relationships between serum matrix metalloproteinases and estrogen receptor-negative breast cancer: a bidirectional mendelian randomization study.

Sci Rep

2023 May 15

Zhao Z(#), Cao Q(#), Zhu M

1046. Association between characteristics of swallowing-related muscles and trunk muscle mass.

Sci Rep

2023 May 15

Yamaguchi K, Nakagawa K, Yoshimi K

1047. Vaginal birth after cesarean section and its associated factors in Ethiopia: a systematic review and meta-analysis.

Sci Rep

2023 May 15

Addisu D, Gebeyehu NA, Biru S

The prevalence of cesarean sections is rising rapidly and is becoming a global issue. Vaginal birth after a cesarean section is one of the safest strategies that can be used to decrease the cesarean section rate. Different fragmented primary studies were done on the success rate of vaginal birth after cesarean section and its associated factors in Ethiopia. However, the findings were controversial and inconclusive. Therefore, this meta-analysis was intended to estimate the pooled success rate of vaginal birth after cesarean section and its associated factors in Ethiopia. Pertinent studies were searched in PubMed, Google Scholar, ScienceDirect, direct open-access journals, and Ethiopian universities' institutional repositories. The data were analyzed using Stata 17. The Newcastle-Ottawa quality assessment tool was used to assess the quality of the studies. I squared statistics and Egger's regression tests were used to assess heterogeneity and publication bias, respectively. A random effects model was selected to estimate the pooled success rate of vaginal birth after cesarean section and its associated factors. The PROSPERO registration number for this review is CRD42023413715. A total of 10 studies were included. The pooled success rate of vaginal birth after a cesarean section was found to be 48.42%. Age less than 30 years (pooled odds ratio (OR) 3.75, 95% CI 1.92, 7.33), previous history of vaginal birth (OR 3.65, 95% CI 2.64, 504), ruptured amniotic membrane at admission (OR 2.87, 95% CI 1.94, 4.26), 4 cm or more cervical dilatation at admission (OR 4, 95% CI 2.33, 6.8), a low station at admission (OR 5.07, 95% CI 2.08, 12.34), and no history of stillbirth (OR 4.93, 95% CI 1.82, 13.36) were significantly associated with successful vaginal birth after cesarean section. In conclusion, the pooled success rate of vaginal birth after a cesarean section was low in Ethiopia. Therefore, the Ministry of Health should consider those identified factors and revise the management guidelines and eligibility criteria for a trial of labor after a cesarean section.

1048. Constraining the tectonic evolution of rifted continental margins by U-Pb calcite dating.

Sci Rep

2023 May 15

Hestnes Å, Drost K, Sømme TO

1049. Oxytocin receptor antagonism during early vocal learning reduces song preference and imitation in zebra finches.

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2023 May 15

Pilgeram NR, Baran NM, Bhise A

1050. Analysis of the difference between early-bolting and non-bolting roots of Angelica dahurica based on transcriptome sequencing.

Sci Rep

2023 May 15

Wu P, Wang X, Guo J

1051. Analysis of spatial and temporal trend of hydro-climatic parameters in the Kilombero River Catchment, Tanzania.

Sci Rep

2023 May 15

Sigalla OZ, Valimba P, Selemani JR

1052. Usefulness of gastric aspirates for diagnosing nontuberculous mycobacteriosis.

Sci Rep

2023 May 15

Shimoda M, Morimoto K, Yoshiyama T

1053. Cluster analysis of autoencoder-extracted FDG PET/CT features identifies multiple myeloma patients with poor prognosis.

Sci Rep

2023 May 15

Lee H, Hyun SH, Cho YS

1054. Transcriptomic and glycomic analyses highlight pathway-specific glycosylation alterations unique to Alzheimer's disease.

Sci Rep

2023 May 15

Tang X(#), Tena J(#), Di Lucente J

Glycosylation has been found to be altered in the brains of individuals with Alzheimer's disease (AD). However, it is unknown which specific glycosylation-related pathways are altered in AD dementia. Using publicly available RNA-seq datasets covering seven brain regions and including 1724 samples, we identified glycosylation-related genes ubiquitously changed in individuals with AD. Several differentially expressed glycosyltransferases found by RNA-seq were confirmed by qPCR in a different set of human medial temporal cortex (MTC) samples (n = 20 AD vs. 20 controls). N-glycan-related changes predicted by expression changes in these glycosyltransferases were confirmed by mass spectrometry (MS)-based N-glycan analysis in the MTC (n = 9 AD vs. 6 controls). About 80% of glycosylation-related genes were differentially expressed in at least one brain region of AD participants (adjusted p-values < 0.05). Upregulation of MGAT1 and B4GALT1 involved in complex N-linked glycan formation and galactosylation, respectively, were reflected by increased concentrations of corresponding N-glycans. Isozyme-specific changes were observed in expression of the polypeptide N-acetylgalactosaminyltransferase (GALNT) family and the alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase (ST6GALNAC) family of enzymes. Several glycolipid-specific genes (UGT8, PIGM) were upregulated. The critical transcription factors regulating the expression of N-glycosylation and elongation genes were predicted and found to include STAT1 and HSF5. The miRNA predicted to be involved in regulating N-glycosylation and elongation glycosyltransferases were has-miR-1-3p and has-miR-16-5p, respectively. Our findings provide an overview of glycosylation pathways affected by AD and potential regulators of glycosyltransferase expression that deserve further validation and suggest that glycosylation changes occurring in the brains of AD dementia individuals are highly pathway-specific and unique to AD.

1055. Impact of body mass index on outcomes after lumbar spine surgery.

Sci Rep

2023 May 15

Nakajima K, Miyahara J, Ohtomo N

1056. Use of machine learning to improve the estimation of conductivity and permittivity based on longitudinal relaxation time T1 in magnetic resonance at 7 T.

Sci Rep

2023 May 15

Hernandez D, Kim KN.

Electrical property tomography (EPT) is a noninvasive method that uses magnetic resonance imaging (MRI) to estimate the conductivity and permittivity of tissues, and hence, can be used as a biomarker. One branch of EPT is based on the correlation of water and relaxation time T1 with the conductivity and permittivity of tissues. This correlation was applied to a curve-fitting function to estimate electrical properties, it was found to have a high correlation between permittivity and T1 however the computation of conductivity based on T1 requires to estimate the water content. In this study, we developed multiple phantoms with several ingredients that modify the conductivity and permittivity and explored the use of machine learning algorithms to have a direct estimation of conductivity and permittivity based on MR images and the relaxation time T1. To train the algorithms, each phantom was measured using a dielectric measurement device to acquire the true conductivity and permittivity. MR images were taken for each phantom, and the T1 values were measured. Then, the acquired data were tested using curve fitting, regression learning, and neural fit models to estimate the conductivity and permittivity values based on the T1 values. In particular, the regression learning algorithm based on Gaussian process regression showed high accuracy with a coefficient of determination R2 of 0.96 and 0.99 for permittivity and conductivity, respectively. The estimation of permittivity using regression learning demonstrated a lower mean error of 0.66% compared to the curve fitting method, which resulted in a mean error of 3.6%. The estimation of conductivity also showed that the regression learning approach had a lower mean error of 0.49%, whereas the curve fitting method resulted in a mean error of 6%. The findings suggest that utilizing regression learning models, specifically Gaussian process regression, can result in more accurate estimations for both permittivity and conductivity compared to other methods.

1057. Synergy of climate change with country success and city quality of life.

Sci Rep

2023 May 15

Kaklauskas A, Abraham A, Kaklauskiene L

1058. Exploring hazard anticipation and stress while driving in light of defensive behavior theory.

Sci Rep

2023 May 15

Kerautret L, Dabic S, Navarro J.

1059. Repurposing of drugs against methyltransferase as potential Zika virus therapies.

Sci Rep

2023 May 15

Shukla R(#), Chandra A(#), Kumar A

1060. Influence of well-being and quality of work-life on quality of care among healthcare professionals in southwest, Nigeria.

Sci Rep

2023 May 15

Odole AC, Ogunlana MO, Odunaiya NA

1061. Outcomes of prostate cancer patients after robot-assisted radical prostatectomy compared with open radical prostatectomy in Korea.

Sci Rep

2023 May 15

Jung J(#), Bae GH(#), Kim JH

1062. Classification of Amazonian fast-growing tree species and wood chemical determination by FTIR and multivariate analysis (PLS-DA, PLS).

Sci Rep

2023 May 15

Javier-Astete R, Melo J, Jimenez-Davalos J

1063. Effect of Bacillus subtilis on mechanical and self-healing properties in mortar with different crack widths and curing conditions.

Sci Rep

2023 May 15

Yamasamit N, Sangkeaw P, Jitchaijaroen W

1064. Influence of the modifiers in polyol method on magnetically induced hyperthermia and biocompatibility of ultrafine magnetite nanoparticles.

Sci Rep

2023 May 15

Radoń A, Włodarczyk A, Sieroń Ł

1065. Occupational radiation exposure to the lens of the eyes and its protection during endoscopic retrograde cholangiopancreatography.

Sci Rep

2023 May 15

Ikezawa K, Hayashi S, Takenaka M

1066. Pareto optimization with small data by learning across common objective spaces.

Sci Rep

2023 May 15

Tan CS, Gupta A, Ong YS

1067. Accurate prognosis for localized prostate cancer through coherent voting networks with multi-omic and clinical data.

Sci Rep

2023 May 15

Pellegrini M.

1068. Reproduction of human blood pressure waveform using physiology-based cardiovascular simulator.

Sci Rep

2023 May 15

Jeong JH, Lee B, Hong J

1069. Genomic variability correlates with biofilm phenotypes in multidrug resistant clinical isolates of Pseudomonas aeruginosa.

Sci Rep

2023 May 15

Islam OK, Islam I, Saha O

The multifactorial nature of Pseudomonas aeruginosa biofilm development and genomic variabilities implicates its resistance to conventional antimicrobials and virulence. Therefore, genetic determinants need to be extensively studied to block the early steps of biofilm or already formed biofilms. In this study, a total of 20 multidrug resistant (MDR) clinical P. aeruginosa isolates were evaluated for their biofilm forming abilities and related genes. Of the isolates tested, all of them showed surface attachment tendencies in nutrient limiting conditions, and classified as strong (SBF = 45%), moderate (MBF = 30%) and weak (WBF = 25%) biofilm formers. Complete genome sequencing of representative strong (DMC-27b), moderate (DMC-20c) and weak biofilm former (DMC-30b) isolates was performed. Analysis of biofilm related genes in the sequenced genomes revealed that, 80 of the 88 biofilm related genes possess 98-100% sequence identity to the reference PAO1 strain. Complete and partial sequence data of LecB proteins from tested isolates indicate that isolates containing PA14-like LecB sequences produced strong biofilms. All of the 7 pel operon protein coding genes in weak biofilm former isolate 30b showed significant nucleotide sequence variation with other tested isolates, and their corresponding proteins are 99% identical with the pel operon proteins of PA7. Bioinformatics analyses identified divergent sequence and structural features that separate PA7 like pel operon proteins from reference PAO1-like pel operon. Congo red and pellicle forming assays revealed that the sequence and structure variations may have interfered with the Pel production pathway and resulted in impaired Pel production in isolate 30b that has a PA7 like pel operon. Expression analysis also showed that both pelB and lecB genes were about 5 to 6 folds upregulated after 24 h in SBF 27b in comparison with WBF 30b. Our findings indicate significant genomic divergence in biofilm related genes of P. aeruginosa strains that affect their biofilm phenotypes.

1070. High-performance selective NO(2) gas sensor based on In(2)O(3)-graphene-Cu nanocomposites.

Sci Rep

2023 May 15

Khort A, Haiduk Y, Taratyn I

1071. PARP2 poly(ADP-ribosyl)ates nuclear factor erythroid 2-related factor 2 (NRF2) affecting NRF2 subcellular localization.

Sci Rep

2023 May 15

Jankó L(#), Tóth E(#), Laczik M

1072. Apoptosis induction in cancer cell lines and anti-inflammatory and anti-pathogenic properties of proteinaceous metabolites secreted from potential probiotic Enterococcus faecalis KUMS-T48.

Sci Rep

2023 May 15

Salek F, Mirzaei H, Khandaghi J

1073. Increased risk of herpes zoster with tofacitinib treatment in Korean patients with rheumatoid arthritis: a single-center prospective study.

Sci Rep

2023 May 15

Song YJ, Cho SK, Kim H

1074. A peleg modeling of water absorption in cold plasma-treated Chickpea (Cicer arietinum L.) cultivars.

Sci Rep

2023 May 15

Pathan FL, Trimukhe AM, Deshmukh RR

1075. Effect of inclined magnetic field on radiative heat and mass transfer in chemically reactive hybrid nanofluid flow due to dual stretching.

Sci Rep

2023 May 15

Arshad M, Alharbi FM, Hassan A

1076. KCC2 downregulation after sciatic nerve injury enhances motor function recovery.

Sci Rep

2023 May 15

Cheung DL, Toda T, Narushima M

1077. Prediction of fatty acid composition in intact and minced fat of European autochthonous pigs breeds by near infrared spectroscopy.

Sci Rep

2023 May 15

Parrini S, Sirtori F, Čandek-Potokar M

1078. TRPM7 kinase mediates hypomagnesemia-induced seizure-related death.

Sci Rep

2023 May 15

Liu M, Liu H, Feng F

1079. Effects of lidocaine incorporation (without epinephrine) on pain and 2-week complications of botulinum toxin: a double-blind randomized placebo-controlled clinical trial.

Sci Rep

2023 May 14

Sarkarat F, Bagheri D, Kahali R

No study has assessed the effects of the incorporation of isolated lidocaine into botulinum toxin for reducing its pain or complications. Studies on the dilution of botulinum toxin with other materials are as well extremely few, small, and limited methodologically. Therefore, we aimed to evaluate, for the first time, the effects of the incorporation of lidocaine alone into botulinum toxin type A on post-injection pain and complications. In this 2-week prospective, multicenter, double-blind randomized placebo-controlled clinical trial, 729 participants (667 females) were enrolled. They were randomized into placebo and lidocaine dilutions (about 2:1), and then into two brands of toxins (Dysport versus Xeomin). Hence, there were 4 subgroups. In the 2 experimental subgroups, botulinum toxin was diluted with 2% lidocaine without adrenaline; in the 2 control subgroups, botulinum toxin was diluted with normal saline as a placebo. After injection, the pain level was recorded (as an 11-scale numerical rating scale from 0 to 10). After 2 weeks, post-injection complications were assessed based on the participants' reports and the surgeon's observations. Data were analyzed using 3-way ANCOVA, multiple binary logistic regression, and bivariable analyses (α = 0.05, β ≤ 0.1). The mean ± SD pain levels in the lidocaine group (n = 263) and the placebo group (n = 466) were 3.51 ± 2.04 and 4.15 ± 2.35, respectively. The mean ± SD pain levels in the subgroups 'Xeomin-Lidocaine (n = 61), Dysport-Lidocaine (n = 202), Xeomin-Placebo (n = 133), and Dysport-Placebo (n = 333)' were respectively 3.39 ± 1.86, 3.55 ± 2.09, 4.61 ± 2.49, and 3.97 ± 2.24. Lidocaine incorporation (P = 0.001), Dysport brand (P = 0.030), and younger age (P = 0.032) [but not sex (P = 0.406)] reduced pain. The only significant findings for 2-week complications were for the associations observed between aging with increased asymmetry (P = 0.022, OR = 1.032) and a need for a retouch (P = 0.039, OR = 1.021). Botulinum toxin dilution with lidocaine alone (without adrenaline or other ingredients) can reduce pain without affecting postinjection complications. Toxin brands may cause different extents of pain. Aging, but not sex, may increase pain. Two-week complications were not affected by any factors, except aging in the case of asymmetry and the need for a botulinum toxin retouch.

1080. Validity and reliability of the Korean caregiver contribution to self-care chronic illness inventory.

Sci Rep

2023 May 14

Lee J, Kim E, Chung M

1081. Dysbiosis of the gut microbiome in elderly patients with hepatocellular carcinoma.

Sci Rep

2023 May 13

Zhang W, Xu X, Cai L

Fecal samples from participants aged 60-80 were collected and sequenced by a high-throughput second-generation sequencer to explore the structural composition of gut microbiota in elderly patients with hepatocellular carcinoma(HCC). Comparison of gut microbiota between patients with hepatocellular carcinoma and healthy controls, α diversity and β diversity were statistically different. At the genus level, compared with the normal group, the abundance of A Blautia, Fusicatenibacter, Anaerostipes, Lachnospiraceae_ND3007_group, CAG-56, Eggerthella, Lachnospiraceae_FCS020_group and Olsenella were decreased significantly in the LC group. In contrast, the abundance of Escherichia-Shigella, Fusobacterium, Megasphaera, Veillonella, Tyzzerella_4, Prevotella_2 and Cronobacter increased significantly. The KEGG and COG pathway analyses showed that the dysbiosis of gut bacteria in primary liver carcinoma is associated with several pathways, including amino acid metabolism, replication and repair, nucleotide metabolism, cell motility, cell growth and death, and transcription. Age is negatively associated with the abundance of Bifidobacterium. Lachnospiraceae_ ND3007_ group, [Eubacterium]_hallii_group, Blautia, Fuscatenibacter and Anaerostipes are negatively correlated with ALT, AST and GGT levels (p < 0.05), respectively. Alpha-fetoprotein (AFP) is positively associated with the abundance of Erysipelatoclostridium, Magasphaera, Prevotella 2, Escherichia-Shigella, Streptococcus and [Eubacterium]_eligens_group (p < 0.05), respectively. A random forest model showed that the genera Eggerthella, Anaerostipes, and Lachnospiraceae_ ND3007_ group demonstrated the best predictive capacity. The area under the Receiver Operating Characteristic Curve of Eggerthella, Anaerostipes and Lachnospiraceae_ ND3007_ group are 0.791, 0.766 and 0.730, respectively. These data are derived from the first known gut microbiome study in elderly patients with hepatocellular carcinoma. Potentially, specific microbiota can be used as a characteristic index for screening, diagnosis, and prognosis of gut microbiota changes in elderly patients with hepatocellular carcinoma and even as a therapeutic clinical target.

1082. Application of supervised machine learning algorithms for classification and prediction of type-2 diabetes disease status in Afar regional state, Northeastern Ethiopia 2021.

Sci Rep

2023 May 13

Ebrahim OA, Derbew G.

Ethiopia has been challenged by the growing magnitude of diabetes in general and type-2 diabetes in particular. Knowledge extraction from stored dataset can be an important base for better decision on diabetes rapid diagnosis, suggestive on prediction for early intervention. Thus, this study was addressed these problem by application of supervised machine learning algorithms for classification and prediction of type 2 diabetes disease status and might provide context-specific information to program planners and policy makers so that, priority will be given to the more affected groups. To apply supervised machine learning algorithms; compare these algorithms and select the best algorithm based on their performance for classification and prediction of type-2 diabetic disease status (positive or negative) in public hospitals of Afar regional state, Northeastern Ethiopia. This study was conducted at Afar regional state from February to June of 2021. Decision tree; pruned J 48, Artificial neural network, K-nearest neighbor, Support vector machine, Binary logistic regression, Random forest, and Naïve Bayes supervised machine learning algorithms were applied using secondary data from the medical database record review. A total of 2239 sample Dataset diagnosed for diabetes from 2012 to April 22/2020 (1523 with type-2 diabetes and 716 without type-2 diabetes) was checked for its completeness prior to analysis. For all algorithms, WEKA3.7 tool was used for analysis purposes. Moreover, all algorithms were compared based on their correctly classification rate, kappa statistics, confusion matrix, area under the curve, sensitivity, and specificity. From the seven major supervised machine learning algorithms, the best classification and prediction results were obtained from random forest [correctly classified rate (93.8%), kappa statistics (0.85), sensitivity (0.98), area under the curve (0.97) and confusion matrix (out of 454 actual positive prediction for 446)] which was followed by decision tree pruned J 48 [correctly classified rate (91.8%), kappa statistics (0.80), sensitivity (0.96), area under the curve (0.91) and confusion matrices (out of 454 actual positive prediction for 438)] and k-nearest neighbor [correctly classified rate (89.8%), kappa statistics (0.76), sensitivity (0.92), area under the curve (0.88) and confusion matrices (out of 454 actual positive prediction for 421)]. Random forest, Decision tree pruned J48 and k-nearest neighbor algorithms have better classification and prediction performance for classifying and predicting type-2 diabetes disease status. Therefore, based on this performance, random forest algorithm can be judged as suggestive and supportive for clinicians at the time of type-2 diabetes diagnosis.

1083. Association between excessive fetal growth and maternal cancer in Shanghai, China: a large, population-based cohort study.

Sci Rep

2023 May 13

Qian N, Yang Q, Chen L

1084. Food Taboo and associated factors among pregnant women attending antenatal clinics at Bahir Dar City, North West Ethiopia, 2021: cross-sectional study.

Sci Rep

2023 May 13

Abere M, Azene AG.

Food taboo is any unacceptable food items in the society that arise mainly based on religious, cultural, historical and social principles. Developing countries faced the triple burden of malnutrition of under nutrition, micronutrient deficiencies and overeating. Food taboos have great effect on pregnant women through prohibited essential food and/or drinks. There is a paucity of study conducted in food taboo practice among pregnant women in Ethiopia. This study aimed to assess the prevalence of food taboo practice and associated factors among pregnant women attending antenatal care (ANC) at Bahir Dar city, 2020. Institutional based cross-sectional study design was conducted among 421 pregnant women attending antenatal care clinics. Stratified sampling technique was used to approach the study participants, and interviewer administered questionnaire was used for data collection. Binary logistic regression analysis was conducted to identify predictors. The prevalence of food taboo practices among pregnant women was 27.5% (95% CI 23.2-31.8%) at the Bahir Dar city. Most food items avoided during pregnancy were meat, honey, milk, fruit and cereals. Reasons for avoidance of these food items were plastered on the fetal head, and making fatty baby which is difficult for deliver. Maternal age 20-30 years (AOR = 8.39, 95% CI 3.49-20.14), more than 30 years [AOR = 10.56, 95% CI (2.00, 51.74)], more than 2 parity [AOR = 9.83 95% CI (2.79, 34.70)], no previous experience of the ANC visit [AOR = 2.68, 95% CI (1.26, 5.73)], and no information about nutrition [AOR = 4.55, 95% CI (1.77, 11.70)] were significantly associated with practice of food taboo. This study revealed that prevalence of food taboo is high during pregnancy. The implications of this study that needs strengthening nutrition counseling components of ANC follow-up and health professionals needs to design and implement strategic health communication intended to reorient misconceptions and myths for the pregnant women regarding the food taboo.

1085. Behavioral and cellular responses to circadian disruption and prenatal immune activation in mice.

Sci Rep

2023 May 13

Delorme TC, Ozell-Landry W, Cermakian N

1086. Assessment of potential pathogenic bacterial load and multidrug resistance in locally manufactured cosmetics commonly used in Dhaka metropolis.

Sci Rep

2023 May 13

Nusrat N(#), Ahmad Zahra M(#), Ahmed A

1087. Socio-cultural practices on the use of beetle grubs as food and feed in western Kenya.

Sci Rep

2023 May 13

Wanjala MN, Orinda M, Nyongesah JM

1088. Importance analysis of psychosociological variables in frailty syndrome in heart failure patients using machine learning approach.

Sci Rep

2023 May 13

Pasieczna AH, Szczepanowski R, Sobecki J

1089. Black electrochromic ink with a straightforward method using copper oxide nanoparticle suspension.

Sci Rep

2023 May 13

Jeong CY, Watanabe H, Tajima K.

1090. An observational study on factors associated with ICU mortality in Covid-19 patients and critical review of the literature.

Sci Rep

2023 May 13

Lavrentieva A, Kaimakamis E, Voutsas V

The novel pandemic caused by SARS-CoV-2 has been associated with increased burden on healthcare system. Recognizing the variables that independently predict death in COVID-19 is of great importance. The study was carried out prospectively in a single ICU in northern Greece. It was based on the collection of data during clinical practice in 375 adult patients who were tested positive for SARS-CoV-2 between April 2020 and February 2022. All patients were intubated due to acute respiratory insufficiency and received Invasive Mechanical Ventilation. The primary outcome was ICU mortality. Secondary outcomes were 28-day mortality and independent predictors of mortality at 28 days and during ICU hospitalization. For continuous variables with normal distribution, t-test was used for means comparison between two groups and one-way ANOVA for multiple comparisons. When the distribution was not normal, comparisons were performed using the Mann-Whitney test. Comparisons between discrete variables were made using the x2 test, whereas the binary logistic regression was employed for the definition of factors affecting survival inside the ICU and after 28 days. Of the total number of patients intubated due to COVID-19 during the study period, 239 (63.7%) were male. Overall, the ICU survival was 49.6%, whereas the 28-day survival reached 46.9%. The survival rates inside the ICU for the four main viral variants were 54.9%, 50.3%, 39.7% and 50% for the Alpha, Beta, Delta and Omicron variants, respectively. Logistic regressions for outcome revealed that the following parameters were independently associated with ICU survival: wave, SOFA @day1, Remdesivir use, AKI, Sepsis, Enteral Insufficiency, Duration of ICU stay and WBC. Similarly, the parameters affecting the 28-days survival were: duration of stay in ICU, SOFA @day1, WBC, Wave, AKI and Enteral Insufficiency. In this observational cohort study of critically ill COVID-19 patients we report an association between mortality and the wave sequence, SOFA score on admission, the use of Remdesivir, presence of AKI, presence of gastrointestinal failure, sepsis and WBC levels. Strengths of this study are the large number of critically ill COVID-19 patients included, and the comparison of the adjusted mortality rates between pandemic waves within a two year-study period.

1091. Clinical spectrum and prognosis of pathologically confirmed atypical tumefactive demyelinating lesions.

Sci Rep

2023 May 13

Zhang Y, Zhang T, Zhang X

1092. Unimproved water and sanitation contributes to childhood diarrhoea during the war in Tigray, Ethiopia: a community based assessment.

Sci Rep

2023 May 13

Asgedom AA, Abirha BT, Tesfay AG

Access to water, sanitation, and hygiene (WASH) is a global public health problem. The situation is worst in conflict areas, where people are displaced from their usual homes. Household supply of WASH and the incidence of diarrhoeal disease among children during the war in Tigray are not known or documented. The objective of this study was to investigate the sources of drinking water, sanitation and hygiene practices, and the incidence of diarrhoeal diseases among children during the war in Tigray, Ethiopia. A cross-sectional study was conducted to collect data on selected WASH indicators in six zones of Tigray from August 4-20, 2021. Data were collected from a total of 4381 sample households selected by lottery. Descriptive analysis was performed and the analysed data are presented in tables, figures and explanatory notes. Binary logistic regression was performed to examine the relationship between independent and dependent variables. A total of 4381 households from 52 woredas participated in the study. Approximately 67.7% of the study participants reported that they relied on an improved source of drinking water during the war. Coverage of sanitation, hand washing, and menstrual hygiene during the war was reported as 43.9%, 14.5%, and 22.1%, respectively. The prevalence of diarrhoeal diseases among children was 25.5% during the war. Water source, latrine type, solid waste disposal and health extension worker visits were the significant predictors of the likelihood of diarrhoea in children (p < 0.05). The results of the study show that a decrease in services from WASH is associated with a higher prevalence of diarrhoeal disease among children during the war in Tigray. To prevent the high prevalence of diarrhoeal disease among children in war-torn Tigray, Ethiopia, improved access to water and sanitation is recommended. In addition, collaborative efforts are needed to engage health extension workers to provide appropriate promotion and prevention services to war-affected communities in Tigray, Ethiopia. Further comprehensive surveys of households with children over one year of age are recommended to assess access to WASH and the burden of WASH associated diseases.

1093. Changes in the epidemiological characteristics of prehospital emergency services before and during the COVID-19 pandemic, Chengdu, 2016-2021.

Sci Rep

2023 May 13

Zhang B, Kang W, Xiong S

1094. Immune gene variation associated with chromosome-scale differences among individual zebrafish genomes.

Sci Rep

2023 May 13

McConnell SC, Hernandez KM, Andrade J

1095. Identifying appropriate prediction models for estimating hourly temperature over diverse agro-ecological regions of India.

Sci Rep

2023 May 13

Bal SK, Pramod VP, Sandeep VM

The present study tests the accuracy of four models in estimating the hourly air temperatures in different agroecological regions of the country during two major crop seasons, kharif and rabi, by taking daily maximum and minimum temperatures as input. These methods that are being used in different crop growth simulation models were selected from the literature. To adjust the biases of estimated hourly temperature, three bias correction methods (Linear regression, Linear scaling and Quantile mapping) were used. When compared with the observed data, the estimated hourly temperature, after bias correction, is reasonably close to the observed during both kharif and rabi seasons. The bias-corrected Soygro model exhibited its good performance at 14 locations, followed by the WAVE model and Temperature models at 8 and 6 locations, respectively during the kharif season. In the case of rabi season, the bias-corrected Temperature model appears to be accurate at more locations (21), followed by WAVE and Soygro models at 4 and 2 locations, respectively. The pooled data analysis showed the least error between estimated (uncorrected and bias-corrected) and observed hourly temperature from 04 to 08 h during kharif season while it was 03 to 08 h during the rabi season. The results of the present study indicated that Soygro and Temperature models estimated hourly temperature with better accuracy at a majority of the locations situated in the agroecological regions representing different climates and soil types. Though the WAVE model worked well at some of the locations, estimation by the PL model was not up to the mark in both kharif and rabi seasons. Hence, Soygro and Temperature models can be used to estimate hourly temperature data during both kharif and rabi seasons, after the bias correction by the Linear Regression method. We believe that the application of the study would facilitate the usage of hourly temperature data instead of daily data which in turn improves the precision in predicting phenological events and bud dormancy breaks, chilling hour requirement etc.

1096. Proof of concept of the potential of a machine learning algorithm to extract new information from conventional SARS-CoV-2 rRT-PCR results.

Sci Rep

2023 May 13

Cabrera Alvargonzález J, Larrañaga Janeiro A, Pérez Castro S

1097. Origin variations and brachial plexus relationship of the dorsal scapular artery.

Sci Rep

2023 May 13

Lai KC, Ho HC.

1098. Prevalence of BRCA homopolymeric indels in an ION Torrent-based tumour-to-germline testing workflow in high-grade ovarian carcinoma.

Sci Rep

2023 May 13

Azzollini J, Agnelli L, Conca E

1099. Comparative study of ternary hybrid nanofluids with role of thermal radiation and Cattaneo-Christov heat flux between double rotating disks.

Sci Rep

2023 May 13

Noreen S, Farooq U, Waqas H

1100. Proof of principle study: synchrotron X-ray fluorescence microscopy for identification of previously radioactive microparticles and elemental mapping of FFPE tissues.

Sci Rep

2023 May 13

Copeland-Hardin L, Paunesku T, Murley JS

1101. Genetic variation in disease resistance in Drosophila spp. is mitigated in Drosophila sechellia by specialization to a toxic host.

Sci Rep

2023 May 13

O'Malley L, Wang J, Nikzad M

1102. Provisioning ecotourism does not increase tiger shark site fidelity.

Sci Rep

2023 May 13

Séguigne C, Bègue M, Meyer C

1103. Optimal low voltage ride through of wind turbine doubly fed induction generator based on bonobo optimization algorithm.

Sci Rep

2023 May 13

Mostafa MA, El-Hay EA, Elkholy MM.

1104. Red background color biases gender categorization of human faces.

Sci Rep

2023 May 13

Chen N, Nakamura K, Watanabe K.

1105. Behavioral and oscillatory signatures of switch costs in highly proficient bilinguals.

Sci Rep

2023 May 12

Timofeeva P, Quiñones I, Geng S

1106. Prediction formulae of sagittal alignment in thoracolumbar kyphosis secondary to ankylosing spondylitis after osteotomy.

Sci Rep

2023 May 12

Luo J, Yang Z, Duan C

To construct and validate prediction formulae of sagittal alignment in thoracolumbar kyphosis secondary to ankylosing spondylitis (AS) after osteotomy. A total of 115 AS patients who suffered from thoracolumbar kyphosis and underwent osteotomy were enrolled, with 85 patients in derivation group and 30 patients in validation group. Radiographic parameters were measured on lateral radiographs, including thoracic kyphosis, lumbar lordosis (LL), T1 pelvic angel (TPA), sagittal vertical axis (SVA), osteotomized vertebral angle, pelvic incidence (PI), pelvic tilt (PT), sacral slope (SS), and PI and LL mismatch (PI-LL). Prediction formulae of SS, PT, TPA and SVA were established; and their effectiveness was evaluated. There was no significant difference in baseline characteristics between the two groups (p > 0.05). In derivation group, LL and PI-LL were correlated with SS, and were then used to establish the prediction formula of SS[SS = - 12.791-0.765 × (LL) + 0.357 × (PI-LL), R2 = 68.3%]; PI and PI-LL were correlated with PT, and the prediction formula of PT were thus established[PT = 12.108 + 0.402 × (PI-LL) + 0.252 × (PI), R2 = 56.8%]; PT, PI-LL and LL were correlated with TPA, and were used to establish the prediction formula of TPA[TPA = 0.225 + 0.597 × (PT) + 0.464 × (PI-LL)-0.161 × (LL), R2 = 87.4%]; PT, PI-LL and age were correlated with SVA, and were used to establish the prediction formula of SVA[SVA = 36.157 + 2.790 × (PI-LL) + 1.657 × (Age)-1.813 × (PT), R2 = 41.5%]. In validation group, the predictive SS, PT, TPA and SVA were basically consistent with corresponding real values; and the mean error between predictive values and real values was of 1.3° in SS, 1.2° in PT, 1.1° in TPA and 8.6 mm in SVA. Postoperative SS, PT, TPA and SVA could be predicted with PI and the planned LL and PI-LL using prediction formulae, providing a method for AS kyphosis to plan postoperative sagittal alignment. Change of pelvic posture after osteotomy was quantitatively evaluated using the formulae.

1107. Quantum AI simulator using a hybrid CPU-FPGA approach.

Sci Rep

2023 May 12

Suzuki T, Miyazaki T, Inaritai T

1108. Quantifying the grapevine xylem embolism resistance spectrum to identify varieties and regions at risk in a future dry climate.

Sci Rep

2023 May 12

Lamarque LJ, Delmas CEL, Charrier G

1109. Radiation shielding performance of metal oxides/EPDM rubber composites using Geant4 simulation and computational study.

Sci Rep

2023 May 12

Alabsy MT, Elzaher MA.

This paper aimed to evaluate the shielding performance of ethylene propylene diene monomer (EPDM) rubber composites filled with 200 phr of different metal oxides (either Al2O3, CuO, CdO, Gd2O3, or Bi2O3) as protective materials against gamma and neutron radiations. For this purpose, different shielding parameters, including the linear attenuation coefficient (μ), mass attenuation coefficient (μ/ρ), mean free path (MFP), half value layer (HVL), and tenth value layer (TVL), were calculated in the energy range between 0.015 and 15 MeV by using the Geant4 Monte Carlo simulation toolkit. The simulated μ/ρ values were validated by the XCOM software to examine the precision of the simulated results. The maximum relative deviation between the Geant4 simulation and XCOM was not greater than 1.41%, confirming the accuracy of the simulated results. Based on μ/ρ values, other significant shielding parameters such as effective atomic number (Zeff), effective electron density (Neff), equivalent atomic number (Zeq), and exposure buildup factor (EBF) were also computed to explore the potential usage of the proposed metal oxide/EPDM rubber composites as radiation protective materials. The study demonstrates that the gamma-radiation shielding performance of the proposed metal oxide/EPDM rubber composites are increasing in the order of EPDM < Al2O3/EPDM < CuO/EPDM < CdO/EPDM < Gd2O3/EPDM < Bi2O3/EPDM. Furthermore, three sudden increases in the shielding capability in some composites occur at 0.0267 MeV for CdO/EPDM, 0.0502 MeV for Gd2O3/EPDM, and 0.0905 MeV for Bi2O3/EPDM composites. This increase in the shielding performance is due to the K absorption edges of Cd, Gd, and Bi, respectively. Regarding the neutron shielding performance, the macroscopic effective removal cross-section for fast neutrons (ƩR) was evaluated for the investigated composites using MRCsC software. The highest ƩR is obtained for Al2O3/EPDM, while the lowest ƩR is obtained for EPDM rubber with no metal oxide content. According to the obtained results, the investigated metal oxide/EPDM rubber composites can be employed as comfortable clothing and gloves designed for workers in radiation facilities.

1110. Converting N(2) molecules into NH(3) with TiO(2)/Fe(3)O(4) composite covered with a thin water layer under ambient condition.

Sci Rep

2023 May 12

Moriya I.

1111. Comprehensive analysis of oxidative stress-related lncRNA signatures in glioma reveals the discrepancy of prognostic and immune infiltration.

Sci Rep

2023 May 12

Shi Z, Wu Y, Zhuo Q

Oxidative stress refers to the process of reactive oxide species (ROS) increase in human body due to various factors, which leads to oxidative damage in human tissues. Current studies have confirmed that sustained oxidative stress is one of the distinctive features throughout the development of tumors. Numerous reports have shown that lncRNAs can regulate the process of oxidative stress through multiple pathways. However, the relationship between glioma-associated oxidative stress and lncRNAs is not clearly investigated. RNA sequencing data of GBM (glioblastoma) and LGG (low grade glioma) and corresponding clinical data were retrieved from the TCGA database. Oxidative stress related lncRNAs (ORLs) were identified by Pearson correlation analysis. Prognostic models for 6-ORLs were structured in the training cohort by univariate Cox regression analysis, multivariate Cox regression analysis and LASSO regression analysis. We constructed the nomogram and verified its predictive efficacy by Calibration curves and DCA decision curves. The biological functions and pathways of 6-ORLs-related mRNAs were inferred by Gene Set Enrichment Analysis. Immune cell abundance and immune function associated with risk score (RS) were estimated by ssGSEA, CIBERSORT and MCPcounter synthetically. External validation of the signature was completed using the CGGA-325 and CGGA-693 datasets. 6-ORLs signature-AC083864.2, AC107294.1, AL035446.1, CRNDE, LINC02600, and SNAI3-AS1-were identified through our analysis as being predictive of glioma prognosis. Kaplan-Meier and ROC curves indicated that the signature has a dependable predictive efficacy in the TCGA training cohort, validation cohort and CGGA-325/CGGA-693 test cohort. The 6-ORLs signature were verified to be independent prognostic predictors by multivariate cox regression and stratified survival analysis. Nomogram built with risk scores had strong predictive efficacy for patients' overall survival (OS). The outcomes of the functional enrichment analysis revealing potential molecular regulatory mechanisms for the 6-ORLs. Patients in the high-risk subgroup presented a significant immune microenvironment of macrophage M0 and cancer-associated fibroblast infiltration which was associated with a poorer prognosis. Finally, the expression levels of 6-ORLs in U87/U251/T98/U138 and HA1800 cell lines were verified by RT-qPCR. The nomogram in this study has been made available as a web version for clinicians. This 6-ORLs risk signature has the capabilities to predict the prognosis of glioma patients, assist in evaluating immune infiltration, and assess the efficacy of various anti-tumor systemic therapy regimens.

1112. Polarity signaling balances epithelial contractility and mechanical resistance.

Sci Rep

2023 May 12

Rübsam M, Püllen R, Tellkamp F

1113. Low eating self-efficacy is associated with unfavorable eating behavior tendencies among individuals with overweight and obesity.

Sci Rep

2023 May 12

Oikarinen N, Jokelainen T, Heikkilä L

Success in long-term weight management depends partly on psychological and behavioral aspects. Understanding the links between psychological factors and eating behavior tendencies is needed to develop more effective weight management methods. This population-based cross-sectional study examined whether eating self-efficacy (ESE) is associated with cognitive restraint (CR), uncontrolled eating (UE), emotional eating (EE), and binge eating (BE). The hypothesis was that individuals with low ESE have more unfavorable eating behavior tendencies than individuals with high ESE. Participants were classified as low ESE and high ESE by the Weight-Related Self-Efficacy questionnaire (WEL) median cut-off point. Eating behavior tendencies were assessed with Three Factor Eating Questionnaire R-18 and Binge Eating Scale, and additionally, by the number of difficulties in weight management. The difficulties were low CR, high UE, high EE, and moderate or severe BE. Five hundred and thirty-two volunteers with overweight and obesity were included in the study. Participants with low ESE had lower CR (p < 0.03) and higher UE, EE, and BE (p < 0.001) than participants with high ESE. Thirty-nine percent of men with low ESE had at least two difficulties in successful weight control while this percentage was only 8% in men with high ESE. In women, the corresponding figures were 56% and 10%. The risk of low ESE was increased by high UE [OR 5.37 (95% CI 1.99-14.51)], high EE [OR 6.05 (95% CI 2.07-17.66)], or moderate or severe BE [OR 12.31 (95% CI 1.52-99.84)] in men, and by low CR [OR 5.19 (95% CI 2.22-12.18)], high UE [OR 7.20 (95% CI 2.41-19.22)], or high EE [OR 23.66 (95% CI 4.79-116.77)] in women. Low ESE was associated with unfavorable eating behavior tendencies and multiple concomitant difficulties in successful weight loss promotion. These eating behavior tendencies should be considered when counseling patients with overweight and obesity.

1114. Fuel, cost, energy efficiency and CO(2) emission performance of PCM integrated wood fiber composite phase change material at different climates.

Sci Rep

2023 May 12

Frahat NB, Ustaoglu A, Gencel O

1115. Characterization of Duffy Binding Protein II-specific CD4(+)T cell responses in Plasmodium vivax patients.

Sci Rep

2023 May 12

Thawornpan P, Malee C, Kochayoo P

1116. The inflammatory prognostic index as a potential predictor of prognosis in metastatic gastric cancer.

Sci Rep

2023 May 12

Ozveren A, Erdogan AP, Ekinci F.

1117. Impaired health-related quality of life in long-COVID syndrome after mild to moderate COVID-19.

Sci Rep

2023 May 12

Malesevic S, Sievi NA, Baumgartner P

1118. Risk factor analysis and nomogram establishment and verification of brain astrocytoma patients based on SEER database.

Sci Rep

2023 May 12

Wang R, Cui J(#), Diao Y(#)

Astrocytoma is a common brain tumor that can occur in any part of the central nervous system. This tumor is extremely harmful to patients, and there are no clear studies on the risk factors for astrocytoma of the brain. This study was conducted based on the SEER database to determine the risk factors affecting the survival of patients with astrocytoma of the brain. Patients diagnosed with brain astrocytoma in the SEER database from 2004 to 2015 were screened by inclusion exclusion criteria. Final screened brain astrocytoma patients were classified into low grade and high grade according to WHO classification. The risk factors affecting the survival of patients with low-grade and high-grade brain astrocytoma were analyzed by univariate Kaplan-Meier curves and log-rank tests, individually. Secondly, the data were randomly divided into training set and validation set according to the ratio of 7:3, and the training set data were analyzed by univariate and multivariate Cox regression, and the risk factors affecting the survival of patients were screened and nomogram was established to predict the survival rates of patients at 3 years and 5 years. The area under the ROC curve (AUC value), C-index, and Calibration curve are used to evaluate the sensitivity and calibration of the model. Univariate Kaplan-Meier survival curve and log-rank test showed that the risk factors affecting the prognosis of patients with low-grade astrocytoma included Age, Primary site, Tumor histological type, Grade, Tumor size, Extension, Surgery, Radiation, Chemotherapy and Tumor number; risk factors affecting the prognosis of patients with high-grade astrocytoma include Age, Primary site, Tumor histological type, Tumor size, Extension, Laterality, Surgery, Radiation, Chemotherapy and Tumor number. Through Cox regression, independent risk factors of patients with two grades were screened separately, and nomograms of risk factors for low-grade and high-grade astrocytoma were successfully established to predict the survival rate of patients at 3 and 5 years. The AUC values of low-grade astrocytoma training set patients were 0.829 and 0.801, and the C-index was 0.818 (95% CI 0.779, 0.857). The AUC values of patients in the validation set were 0.902, 0.829, and the C-index was 0.774 (95% CI 0.758, 0.790), respectively. The AUC values of high-grade astrocytoma training set patients were 0.814 and 0.806, the C-index was 0.774 (95% CI 0.758, 0.790), the AUC values of patients in the validation set were 0.802 and 0.823, and the C-index was 0.766 (95% CI 0.752, 0.780), respectively, and the calibration curves of the two levels of training set and validation set were well fitted. This study used data from the SEER database to identify risk factors affecting the survival prognosis of patients with brain astrocytoma, which can provide some guidance for clinicians.

1119. Prediction of mammalian tissue-specific CLOCK-BMAL1 binding to E-box DNA motifs.

Sci Rep

2023 May 12

Marri D, Filipovic D, Kana O

1120. Atretic preovulatory follicles could be precursors of ovarian lutein cysts in the pig.

Sci Rep

2023 May 12

Ziecik AJ, Likszo P, Klos J

1121. Ceramide present in cholangiocarcinoma-derived extracellular vesicle induces a pro-inflammatory state in monocytes.

Sci Rep

2023 May 12

Oliviero B(#), Dei Cas M(#), Zulueta A

1122. Maximum gain enhancement in wireless power transfer using anisotropic metamaterials.

Sci Rep

2023 May 12

Harris WC, Ricketts DS.

1123. Tumor therapeutic response monitored by telemetric temperature sensing, a preclinical study on immunotherapy and chemotherapy.

Sci Rep

2023 May 12

Shao Q, Lundgren M, Lynch J

1124. Transcutaneous auricular vagus nerve stimulation as a potential novel treatment for polycystic ovary syndrome.

Sci Rep

2023 May 12

Zhang S, He H, Wang Y

1125. One-pot synthesis of CdS/CeO(2) heterojunction nanocomposite with tunable bandgap for the enhanced advanced oxidation process.

Sci Rep

2023 May 12

Gadore V, Mishra SR, Ahmaruzzaman M.

1126. Factors influencing axial elongation in myopic children using overnight orthokeratology.

Sci Rep

2023 May 12

Huang Z, Zhao W, Mao YZ

1127. Influence of grape consumption on the human microbiome.

Sci Rep

2023 May 12

Dave A, Beyoğlu D, Park EJ

Over the years, a substantial body of information has accumulated suggesting dietary consumption of grapes may have a positive influence on human health. Here, we investigate the potential of grapes to modulate the human microbiome. Microbiome composition as well as urinary and plasma metabolites were sequentially assessed in 29 healthy free-living male (age 24-55 years) and female subjects (age 29-53 years) following two-weeks of a restricted diet (Day 15), two-weeks of a restricted diet with grape consumption (equivalent to three servings per day) (Day 30), and four-weeks of restricted diet without grape consumption (Day 60). Based on alpha-diversity indices, grape consumption did not alter the overall composition of the microbial community, other than with the female subset based on the Chao index. Similarly, based on beta-diversity analyses, the diversity of species was not significantly altered at the three time points of the study. However, following 2 weeks of grape consumption, taxonomic abundance was altered (e.g., decreased Holdemania spp. and increased Streptococcus thermophiles), as were various enzyme levels and KEGG pathways. Further, taxonomic, enzyme and pathway shifts were observed 30 days following the termination of grape consumption, some of which returned to baseline and some of which suggest a delayed effect of grape consumption. Metabolomic analyses supported the functional significance of these alterations wherein, for example, 2'-deoxyribonic acid, glutaconic acid, and 3-hydroxyphenylacetic acid were elevated following grape consumption and returned to baseline following the washout period. Inter-individual variation was observed and exemplified by analysis of a subgroup of the study population showing unique patterns of taxonomic distribution over the study period. The biological ramifications of these dynamics remain to be defined. However, while it seems clear that grape consumption does not perturb the eubiotic state of the microbiome with normal, healthy human subjects, it is likely that shifts in the intricate interactive networks that result from grape consumption have physiological significance of relevance to grape action.

1128. FOXK1 regulates malignant progression and radiosensitivity through direct transcriptional activation of CDC25A and CDK4 in esophageal squamous cell carcinoma.

Sci Rep

2023 May 12

Li X, Lu J, Liu L

1129. Studying the concentration of polymers in blended microplastics using 2D and 3D Raman mapping.

Sci Rep

2023 May 12

Lotfi Choobbari M, Ferguson J, Van den Brande N

1130. Mixed effects logistic regression analysis of blood pressure among Ghanaians and associated risk factors.

Sci Rep

2023 May 12

Iddrisu AK, Besing Karadaar I, Gurah Junior J

Blood pressure (BP) control is a global health issue with an increase in BP beyond the normal BP leading to different stages of hypertension in humans and hence the need to identify risk factors of BP for efficient and effective control. Multiple BP measurement have proven to provide BP readings close to the true BP status of the individual. In this study, we used multiple BP measurement data on 3809 Ghanaians to determine risk factors associated with BP. The data were obtained from World Health Organization study on Global AGEing and Adult Health. We defined high blood pressure (HBP) as [Formula: see text] 130/80 mmHg or normal as [Formula: see text] 130/80 mmHg. We provide summary statistics and also used the Chi-Square test to assess significance of association between HBP versus risk factors of HBP. The aim of this study is to identify risk factors of BP using the mixed effects logistic regression model. Data were analyzed using R version 4.2.2. The results showed that the risk of high blood pressure (HBP) decreases across the three measurement periods. There is reduced risk (OR = 0.274, 95% CI = 0.2008, 0.405) of HBP among male participants relative to female participants. The risk (OR = 2.771, 95% CI = 1.8658, 4.1145) of HBP increased by 2.771-folds among those who are 60 years and above relative to those below the age of 60 years. Those whose work involves/requires vigorous exercise has 1.631-fold increase in the risk (OR = 1.631, 95% CI = 1.1151, 2.3854) of HBP relative to those whose work does not involve vigorous exercise. There is approximately 5-folds increased in the risk (OR = 4.896, 95% CI = 1.9535, 12.2268) of among those who have ever been diagnosed with diabetes. The results also revealed high risk (OR = 1.649, 95%CI = 1.1108, 2.4486) of HBP among those who have formal education. The risk (OR = 1.009, 95% CI = 1.0044, 1.0137) of HBP increases with increasing weight and a reduced risk (OR = 0.996, 95% CI = 0.9921, 0.9993) of HBP with increasing height. We found that sad experience, either mild, moderate or severe, is associated with a reduced risk of HBP. Those who have vegetable servings at least 2 cups per day have increased risk of HBP and those who have fruits servings at least 2 cups per day is associated with a reduced risk of HBP, however this is not statistically significant. To achieve success in BP control, programs should be designed with the aim of reducing weight, educate those with formal eduction on issues relating to HBP. Those whose work requires vigorous exercise are recommended to have regular check-ups to ensure that pressure build-up in the lungs is cleared. SBP is lower for women at young age but continue to increase after menopause as their BP increase becomes salt-sensitive. Hence there is need to give more attention to menopausal women so as to improve BP. Both young and old individuals are recommended to practice regular exercise since this has shown to reduce risk of being overweight or becoming diabetic and reduces the risk of HBP at yong age and old age. Also, to improve blood pressure control, programs for management of blood pressure or hypertension should focus more short stature individuals since such people are more likely to experience HBP.

1131. A novel HIV model through fractional enlarged integral and differential operators.

Sci Rep

2023 May 12

Barakat MA, Hyder AA, Almoneef AA.

1132. Evidence of inter-state coordination amongst state-backed information operations.

Sci Rep

2023 May 12

Wang X, Li J, Srivatsavaya E

1133. The quantitative investigation of spark plasma on skin parameters with skin elasticity, thickness, density, and biometric characteristics.

Sci Rep

2023 May 12

Ghasemi E(#), Nilforoushzadeh MA(#), Khani M

1134. Effect of basal metabolic rate on lifespan: a sex-specific Mendelian randomization study.

Sci Rep

2023 May 12

Ng JCM, Schooling CM.

1135. Modular architecture and resilience of structural covariance networks in first-episode antipsychotic-naive psychoses.

Sci Rep

2023 May 12

Lewis M, Santini T, Theis N

1136. Discovery of two new isoforms of the human DUT gene.

Sci Rep

2023 May 12

Rácz GA, Nagy N, Várady G

1137. Consensus clustering methodology to improve molecular stratification of non-small cell lung cancer.

Sci Rep

2023 May 12

Manganaro L(#), Bianco S(#), Bironzo P

1138. Lane line detection at nighttime on fractional differential and central line point searching with Fragi and Hessian.

Sci Rep

2023 May 12

Li L, Wang W, Wang M

1139. Examining the relationship between risky sexual behavior and suicidal thoughts among unmarried adolescents in India.

Sci Rep

2023 May 12

Maurya C, Muhammad T, Thakkar S.

Addressing the problem of suicidal thoughts in adolescents requires understanding the associated risk factors. Multiple studies have shown that risky sexual behavior affected the adolescents' psychological health that leads to their suicidal thoughts, behaviors and attempts. This study aimed to identify the association between various risky sexual behaviours and suicidal thoughts among unmarried adolescents in India. We used data collected from 4221 unmarried adolescent boys and 5987 unmarried adolescent girls aged 10-19 years, from the two rounds of the Understanding the Lives of Adolescents and Young Adults (UDAYA) survey. Descriptive analysis was done to observe changes in the selected variables from wave-1 to wave-2. Random effect regression analysis was used to estimate the association of suicidal thoughts among unmarried adolescents with their risky sexual behaviours. The percentage of adolescent boys having suicidal thoughts increased from 1.35% in wave 1 to 2.19% in wave 2. Among adolescent girls, the percentage increased from 2.92% in wave 1 to 5.05% in wave 2. A proportion of 3.26% adolescent boys had more than one sexual partner during wave 1 whereas in wave 2, it rose to 8.71%, while in case of adolescent girls, the estimates only increased from 0.26% at wave 1 to 0.78% at wave 2. Nearly 4.55% boys and 1.37% girls had early sexual debut. Almost five percentage boys were sexually active at wave 1 whereas in wave 2, it rose to 13.56%, while among adolescent girls, the estimates decreased from 1.54% at wave 1 to 1.51% at wave 2. Contraceptive use increased over time among both adolescent boy and girls. Also, a large proportion of adolescent boys reported watching pornography (27.08% at waive 1 and 49.39% at wave 2) compared to adolescent girls (4.46% at wave 1 and 13.10% at wave 2). Adolescents who had more than one sexual partner [Coef: 0.04; p < 0.001], exposed to early sexual debut [Coef; 0.019; p < 0.01], sexually active [Coef: 0.058; p < 0.001] and reported watching pornography [Coef: 0.017; p < 0.001] were more likely to have suicidal thoughts. Adolescent boys and girls with risky sexual behaviors are likely to be at a higher risk of suicidal ideation, and thus, they should be treated with special care and attention by local healthcare practitioners.

1140. Numerical simulation of the nanofluid flow consists of gyrotactic microorganism and subject to activation energy across an inclined stretching cylinder.

Sci Rep

2023 May 12

A Othman H, Ali B, Jubair S

1141. Slow advancement of the endotracheal tube during fiberoptic-guided tracheal intubation reduces the severity of postoperative sore throat.

Sci Rep

2023 May 12

Kim H, Kim JE, Kim Y

1142. Egyptian propolis extract for functionalization of cellulose nanofiber/poly(vinyl alcohol) porous hydrogel along with characterization and biological applications.

Sci Rep

2023 May 12

Saleh S, Salama A, Ali AM

1143. Efficacious elimination of crystal violet pollutant via photo-Fenton process based on Gd((2-x))La((x))Zr(2)O(7) nanoparticles.

Sci Rep

2023 May 12

Abdelbaky M, Abdelghany AM, Oraby AH

Sci Rep

2023 May 12

Hossain MJ, Islam MW, Munni UR

1145. Whole spectrum of Aeromonas hydrophila virulence determinants and the identification of novel SNPs using comparative pathogenomics.

Sci Rep

2023 May 12

Abdella B, Abozahra NA, Shokrak NM

1146. Prediction and experimental validation approach to improve performance of novel hybrid bio-inspired 3D printed lattice structures using artificial neural networks.

Sci Rep

2023 May 12

Doodi R, Gunji BM.

1147. Optimizing the input feature sets and machine learning algorithms for reliable and accurate estimation of continuous, cuffless blood pressure.

Sci Rep

2023 May 12

Kasbekar RS, Ji S, Clancy EA

1148. Brain-derived neurotrophic factor measurements in mouse serum and plasma using a sensitive and specific enzyme-linked immunosorbent assay.

Sci Rep

2023 May 12

Want A, Morgan JE, Barde YA.

1149. Variation along P2RX7 interacts with early traumas on severity of anxiety suggesting a role for neuroinflammation.

Sci Rep

2023 May 12

Kristof Z, Gal Z, Torok D

1150. A smart approach to EMG envelope extraction and powerful denoising for human-machine interfaces.

Sci Rep

2023 May 12

Esposito D, Centracchio J, Bifulco P

1151. A novel of WS(2)-MoCuO(3) supported with graphene quantum dot as counter electrode for dye-sensitized solar cells application.

Sci Rep

2023 May 12

Areerob Y, Oh WC, Hamontree C

1152. Millisecond flash lamp curing for porosity generation in thin films.

Sci Rep

2023 May 12

Attallah AG, Prucnal S, Buttering M

1153. The intentions of information sources can affect what information people think qualifies as true.

Sci Rep

2023 May 12

Handley-Miner IJ, Pope M, Atkins RK

1154. Effects of maternal social isolation on adult rodent offspring cognition.

Sci Rep

2023 May 12

McDonald RJ, Hong NS, Trow JS

Prenatal experiences can influence offspring physiology and behaviour through the lifespan. Various forms of prenatal stress impair adult learning and memory function and can lead to increased occurrence of anxiety and depression. Clinical work suggests that prenatal stress and maternal depression lead to similar outcomes in children and adolescents, however the long-term effects of maternal depression are less established, particularly in well controlled animal models. Social isolation is common in depressed individuals and during the recent COVID-19 pandemic. Accordingly, for this study we were interested in the effects of maternal stress induced via social isolation on adult offspring cognitive functions including spatial, stimulus-response, and emotional learning and memory that are mediated by different networks centered on the hippocampus, dorsal striatum, and amygdala, respectively. Tasks included a discriminative contextual fear conditioning task and cue-place water task. Pregnant dams in the social isolation group were single housed prior to and throughout gestation. Once offspring reached adulthood the male offspring were trained on a contextual fear conditioning task in which rats were trained to associate one of two contexts with an aversive stimulus and the opposing context remained neutral. Afterwards a cue-place water task was performed during which they were required to navigate to both a visible and invisible platform. Fear conditioning results revealed that the adult offspring of socially isolated mothers, but not controls, were impaired in associating a specific context with a fear-inducing stimulus as assessed by conditioned freezing and avoidance. Results from the water task indicate that adult offspring of mothers that were socially isolated showed place learning deficits but not stimulus-response habit learning on the same task. These cognitive impairments, in the offspring of socially isolated dams, occurred in the absence of maternal elevated stress hormone levels, anxiety, or altered mothering. Some evidence suggested that maternal blood-glucose levels were altered particularly during gestation. Our results provide further support for the idea that learning and memory networks, centered on the amygdala and hippocampus are particularly susceptible to the negative impacts of maternal social isolation and these effects can occur without elevated glucocorticoid levels associated with other forms of prenatal stress.

1155. Association of accelerometer-measured physical activity, back static muscular endurance and abdominal obesity with radicular pain and non-specific low back pain.

Sci Rep

2023 May 12

Bayartai ME, Määttä J, Karppinen J

Low back pain (LBP) is the leading cause of disability worldwide and often associated with lifestyle factors. However, studies further examining the role of these lifestyle factors in non-specific low back pain in comparison with radicular pain are sparse. The aim of this cross sectional study was to investigate how diverse lifestyle factors are associated with LBP. The study population of 3385 middle aged adults with and without low back pain was drawn from a large Birth 1966 Cohort. Outcome measures were steps per day, abdominal obesity, physical activity and endurance of the back muscles. Back static muscular endurance, abdominal obesity and physical activity were measured by means of the Biering-Sørensen test, waist circumference and a wrist worn accelerometer, respectively. Logistic regression analysis was applied to estimate associations of back static muscular endurance, abdominal obesity and accelerometer-measured physical activity with non-specific low back pain and radicular pain. An additional 1000 steps per day were associated with 4% lower odds of having non-specific low back pain. Participants with abdominal obesity had 46% higher odds of having radicular pain, whereas increases of 10 s in back static muscular endurance and 10 min in daily vigorous physical activity were associated with 5% and 7% lower odds of having radicular pain, respectively. In this population-based study, non-specific low back pain and radicular pain were associated with different lifestyle and physical factors at midlife. Non-specific low back pain was associated only with the average daily number of steps, whereas abdominal obesity was the strongest determinant of radicular pain, followed by vigorous physical activity and back static muscular endurance. The findings of this study contribute to better understand the role of lifestyle factors in both non-specific low back pain and radicular pain. Future longitudinal studies are required to explore causality.

1156. The association between body mass index, abdominal fatness, and weight change and the risk of adult asthma: a systematic review and meta-analysis of cohort studies.

Sci Rep

2023 May 12

Parasuaraman G, Ayyasamy L, Aune D

1157. Shorter planning depth and higher response noise during sequential decision-making in old age.

Sci Rep

2023 May 11

Steffen J, Marković D, Glöckner F

1158. Vacuolar control of stomatal opening revealed by 3D imaging of the guard cells.

Sci Rep

2023 May 11

Mirasole FM, Nastasi SP, Cubero-Font P

1159. Brain activity underlying visual search in depth when viewing volumetric multiplanar images.

Sci Rep

2023 May 11

Naderi M, Pladere T, Alksnis R

1160. Development and modeling of a novel type of photoreactors with exterior ultraviolet (UV) reflector for water treatment applications.

Sci Rep

2023 May 11

Hassanpour A, Jalali A, Raisee M

1161. H(2)O(2) selectively damages the binuclear iron-sulfur cluster N1b of respiratory complex I.

Sci Rep

2023 May 11

Strotmann L, Harter C, Gerasimova T

1162. Comparison of high-dose IVIG and rituximab versus rituximab as a preemptive therapy for de novo donor-specific antibodies in kidney transplant patients.

Sci Rep

2023 May 11

Kim HW(#), Lee J(#), Heo SJ

1163. Multimodal perturbation analyses of cyclin-dependent kinases reveal a network of synthetic lethalities associated with cell-cycle regulation and transcriptional regulation.

Sci Rep

2023 May 11

Ford K(#), Munson BP(#), Fong SH(#)

1164. PALB2 germline mutations in a large cohort of Middle Eastern breast-ovarian cancer patients.

Sci Rep

2023 May 11

Siraj AK(#), Bu R(#), Parvathareddy SK

1165. Online quantum time series processing with random oscillator networks.

Sci Rep

2023 May 11

Nokkala J.

1166. Neuromuscular activation of the quadriceps femoris, including the vastus intermedius, during isokinetic knee extensions.

Sci Rep

2023 May 11

Akima H, Maeda K, Shima N.

1167. Shallow shotgun sequencing reduces technical variation in microbiome analysis.

Sci Rep

2023 May 11

La Reau AJ, Strom NB, Filvaroff E

1168. Early detection of Solanum lycopersicum diseases from temporally-aggregated hyperspectral measurements using machine learning.

Sci Rep

2023 May 11

Tomaszewski M, Nalepa J, Moliszewska E

1169. Maturity-associated variation in the body size, physical fitness, technical efficiency, and network-based centrality measures in young soccer players.

Sci Rep

2023 May 11

Borges PH, da Costa JC, Ramos-Silva LF

1170. Potential drivers of human tick-borne encephalitis in the Örebro region of Sweden, 2010-2021.

Sci Rep

2023 May 11

Kjær LJ, Johansson M, Lindgren PE

1171. Sputum handling for rheology.

Sci Rep

2023 May 11

Esteban Enjuto L, Robert de Saint Vincent M, Maurin M

1172. Identification of three elevenin receptors and roles of elevenin disulfide bond and residues in receptor activation in Aplysia californica.

Sci Rep

2023 May 11

Fu P, Mei YS, Liu WJ

1173. Distinct histopathological features are associated with molecular subtypes and outcome in low grade serous ovarian carcinoma.

Sci Rep

2023 May 11

Hollis RL(#), Thomson JP(#), van Baal J(#)

1174. Genome-wide identification and comparative analysis of Dmrt genes in echinoderms.

Sci Rep

2023 May 11

Wang Q, Cao T, Wang Y

1175. Comparison of the effects of oxidative and inflammatory stresses on rat chondrocyte senescence.

Sci Rep

2023 May 11

Yagi M, Endo K, Komori K

1176. Exploring pharmaphylogeny from multiple perspectives: a case study on Lithospermeae.

Sci Rep

2023 May 11

Yan Y, Wei X, Qiu B

1177. Elevated serum uric acid is associated with infertility in women living in America.

Sci Rep

2023 May 11

Hong X(#), Zhao F(#), Wang W

Excessive uric acid levels may affect several organs and systems in the body. There is limited evidence of the effects of high serum uric acid levels on the female reproductive system. This study used the National Health and Nutrition Examination Survey (NHANES) database to explore the relationship between serum uric acid and female infertility. This cross-sectional study included a total of 2197 eligible subjects using data from NHANES 2013-March 2020 pre-pandemic data. Self-reported infertility (ever experiencing an inability to conceive after 12 months of trying to become pregnant) was the main outcome. Logistic regression models and restricted cubic spline were used to analyze the relationship between serum uric acid and female infertility, and stratified analysis was carried out. A total of 295 women self-reported infertility (13.43%). The median uric acid level for all study subjects was 4.4 mg/dL (interquartile range [IQR]: 3.7, 5.1). Serum uric acid levels were higher in the infertility group than in the control group (4.7 mg/dL [IQR: 4.0, 5.3] vs. 4.4 mg/dL [IQR: 3.7, 5.1], P < 0.001). After adjusting for age, race, marital status, smoking, alcohol, history of pregnancy, history of diabetes, history of hypertension, fasting glucose, total cholesterol, creatinine in refrigerated serum, low-density lipoprotein cholesterol, direct high-density lipoprotein cholesterol, glycohemoglobin, and body mass index confounders, women with serum uric acid levels at Q3 (4.4-5.1 mg/dL) had a 73% (odds ratio [OR] = 1.73, 95% confidence interval [CI] 1.18, 2.54, P = 0.005) higher risk of infertility, and women with uric acid levels at Q4 (5.1-18.0 mg/dL) had an 83% (OR = 1.83, 95% CI 1.22, 2.75, P = 0.003) increased risk of infertility compared to women at Q1 (1.6-3.7 mg/dL). The restricted cubic spline also showed that when serum uric acid levels exceeded the reference value, the risk of infertility gradually increased. We also performed a sensitivity analysis based on the complete dataset and found that the results were robust. Higher serum uric acid levels were significantly associated with an increased risk of female infertility. Women planning a pregnancy should have increased serum uric acid monitoring.

1178. A CRISPR-engineered isogenic model of the 22q11.2 A-B syndromic deletion.

Sci Rep

2023 May 11

Paranjape N, Lin YT, Flores-Ramirez Q

1179. Associations of active commuting to school in childhood and physical activity in adulthood.

Sci Rep

2023 May 11

Kaseva K, Lounassalo I, Yang X

1180. Chunking as a rational solution to the speed-accuracy trade-off in a serial reaction time task.

Sci Rep

2023 May 11

Wu S, Éltető N, Dasgupta I

1181. Spatio-temporal variations of extract produced and fatty acid compounds identified of Gundelia tournefortii L. seeds in central Zagros, Iran.

Sci Rep

2023 May 11

Karimzadeh HR, Farhang HR, Rahimmalek M

1182. The spatial spillover effect of ICT development level on regional CO(2) emissions.

Sci Rep

2023 May 11

Su J, Wang W, Tang S.

1183. MSRDL: Deep learning framework for service recommendation in mashup creation.

Sci Rep

2023 May 11

Yu T, Liu H, Zhang L

1184. Evaluation of administrative case definitions for hypertension in Canadian children.

Sci Rep

2023 May 11

Dart A, Singer A, Chanchlani R

1185. Combinatorial immunotherapy with gemcitabine and ex vivo-expanded NK cells induces anti-tumor effects in pancreatic cancer.

Sci Rep

2023 May 11

Koh EK(#), Lee HR(#), Son WC(#)

1186. Tuning the acidity of halloysite by polyionic liquid to develop an efficient catalyst for the conversion of fructose to 5-hydroxymethylfurfural.

Sci Rep

2023 May 11

Sadjadi S, Yaghoubi S, Zhong X

1187. Efficacy of a newly developed guidewire for selective biliary access.

Sci Rep

2023 May 11

Park DH(#), Han JH(#), Lee TH

1188. Polarization-insensitive planar patch antenna with large embedded serial capacitance for on-metal tag design.

Sci Rep

2023 May 11

Murugesh M, Lim EH, Chee PS

1189. Fe(3)O(4)@SiO(2)@KIT-6@2-ATP@Cu(I) as a catalyst for hydration of benzonitriles and reduction of nitroarenes.

Sci Rep

2023 May 11

Moradi Z, Ghorbani-Choghamarani A.

1190. Atrial high-rate episodes intensify R(2)CHA(2)DS(2)-VASc score for prognostic stratification in pacemaker patients.

Sci Rep

2023 May 11

Li YP, Chen JY, Chen TW

Patients with device detected atrial high-rate episodes (AHRE) have an increased risk of MACE. The R2CHA2DS2-VASc, CHADS2, R2CHADS2 and CHA2DS2-VASc score have been investigated for predicting major adverse cardiovascular events (MACE) in different groups of patients. We aimed to evaluate the R2CHA2DS2-VASc score in combination with AHRE ≥ 6 min for predicting MACE in patients with dual-chamber PPM but no prior atrial fibrillation (AF). We retrospectively enrolled 376 consecutive patients undergoing dual-chamber PPM implantation and no prior AF. The primary endpoint was subsequent MACE. For all patients in the cohort, CHADS2, R2CHADS2, CHA2DS2-VASc, R2CHA2DS2-VASc scores and AHRE ≥ or < 6 min were determined. AHRE was recorded as a heart rate > 175 bpm (Medtronic) or > 200 bpm (Biotronik) lasting ≥ 30 s. Multivariate Cox regression analysis with time-dependent covariates was used to determine the independent predictors of MACE. ROC-AUC analysis was performed for CHADS2, R2CHADS2, CHA2DS2-VASc, and R2CHA2DS2-VASc scores and then adding AHRE ≥ 6 min to the four scores. The median age was 77 years, and 107 patients (28.5%) developed AHRE ≥ 6 min. After a median follow-up of 32 months, 46 (12.2%) MACE occurred. Multivariate Cox regression analysis showed that R2CHA2DS2-VASc score (HR, 1.485; 95% CI, 1.212-1.818; p < 0.001) and AHRE ≥ 6 min (HR, 2.125; 95% CI, 1.162-3.887; p = 0.014) were independent predictors for MACE. The optimal R2CHA2DS2-VASc score cutoff value was 4.5 (set at ≥ 5), with the highest Youden index (AUC, 0.770; 95% CI, 0.709-0.831; p < 0.001). ROC-AUC analysis of the four risk scores separately combined with AHRE ≥ 6 min all showed better discriminatory power than the four scores alone (All Z-statistic p < 0.05). In patients with PPM who develop AHRE ≥ 6 min, it is crucial to perform risk assessment with either four scores to further stratify risk for MACE.

1191. Numerical analysis of Phase change material and graphene-based tunable refractive index sensor for infrared frequency spectrum.

Sci Rep

2023 May 11

Aliqab K, Dave K, Sorathiya V

1192. Maternal separation leads to dynamic changes of visceral hypersensitivity and fecal metabolomics from childhood to adulthood.

Sci Rep

2023 May 11

Chen X, Hu C, Yan C

1193. Construction and integrated analysis of the ceRNA network hsa_circ_0000672/miR-516a-5p/TRAF6 and its potential function in atrial fibrillation.

Sci Rep

2023 May 11

Liu X, Wu M, He Y

Atrial fibrosis is a crucial contributor to initiation and perpetuation of atrial fibrillation (AF). This study aimed to identify a circRNA-miRNA-mRNA competitive endogenous RNA (ceRNA) regulatory network related to atrial fibrosis in AF, especially to validate hsa_circ_0000672/hsa_miR-516a-5p/TRAF6 ceRNA axis in AF preliminarily. The circRNA-miRNA-mRNA ceRNA network associated with AF fibrosis was constructed using bioinformatic tools and literature reviews. Left atrium (LA) low voltage was used to represent LA fibrosis by using LA voltage matrix mapping. Ten controls with sinus rhythm (SR), and 20 patients with persistent AF including 12 patients with LA low voltage and 8 patients with LA normal voltage were enrolled in this study. The ceRNA regulatory network associated with atrial fibrosis was successfully constructed, which included up-regulated hsa_circ_0000672 and hsa_circ_0003916, down-regulated miR-516a-5p and five up-regulated hub genes (KRAS, SMAD2, TRAF6, MAPK11 and SMURF1). In addition, according to the results of Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis, these hub genes were clustered in TGF-beta and MAPK signaling pathway. In the patients with persistent AF, hsa_circ_0000672 expression in peripheral blood monocytes was significantly higher than those in controls with SR by quantitative real-time polymerase chain reaction (p-value < 0.001). Furthermore, hsa_circ_0000672 expression was higher in peripheral blood monocytes of persistent AF patients with LA low voltage than those with LA normal voltage (p-value = 0.002). The dual-luciferase activity assay confirmed that hsa_circ_0000672 exerted biological functions as a sponge of miR-516a-5p to regulate expression of its target gene TRAF6. Hsa_circ_0000672 expression in peripheral blood monocytes may be associated with atrial fibrosis. The hsa_circ_0000672 may be involved in atrial fibrosis by indirectly regulating TRAF6 as a ceRNA by sponging miR-516a-5p.

1194. Refraining from interaction can decrease fear of physical closeness during COVID-19.

Sci Rep

2023 May 11

Kühne K, Jeglinski-Mende MA.

Perception of peripersonal space (PPS) and interpersonal distance (IPD) has been shown to be modified by external factors such as perceived danger, the use of tools, and social factors. Especially in times of social distancing in the context of the COVID-19 pandemic, it is vital to study factors that modify PPS and IPD. The present work addresses the question of whether wearing a face mask as a protection tool and social interaction impact the perception of IPD. We tested estimated IPD in pictures at three distances: 50 cm, 90 cm, and 150 cm in both social interaction (shaking hands) and without interaction and when the two people in the pictures wore a face mask or not. Data from 60 subjects were analyzed in a linear mixed model (on both difference in distance estimation to the depicted distance and in absolute distance estimation) and in a 3 (distance: 50, 90, 150) × 2 (interaction: no interaction, shake hands), × 2 face mask (no mask, mask) rmANOVA on distance estimation difference. All analyses showed that at a distance of 50 and 90 cm, participants generally underestimated the IPD while at an IPD of 150 cm, participants overestimated the distance. This could be grounded in perceived danger and avoidance behavior at closer distances, while the wider distance between persons was not perceived as dangerous. Our findings at an IPD of 90 cm show that social interaction has the largest effect at the border of our PPS, while the face mask did not affect social interaction at either distance. In addition, the ANOVA results indicate that when no social interaction was displayed, participants felt less unsafe when depicted persons wore a face mask at distances of 90 and 150 cm. This shows that participants are on the one hand aware of the given safety measures and internalized them; on the other hand, that refraining from physical social interaction helps to get close to other persons.

1195. Non-invasive identification of combined salinity stress and stalk rot disease caused by Colletotrichum graminicola in maize using Raman spectroscopy.

Sci Rep

2023 May 11

Higgins S(#), Joshi R(#), Juarez I

1196. Respiratory arousal threshold among patients with isolated sleep apnea and with comorbid insomnia (COMISA).

Sci Rep

2023 May 11

Yanagimori M, Fernandes MD, Garcia ML

1197. Multiple donor-acceptor design for highly luminescent and stable thermally activated delayed fluorescence emitters.

Sci Rep

2023 May 11

Madushani B, Mamada M, Goushi K

1198. Cross talk between bacterial and human gene networks enriched using ncRNAs in IBD disease.

Sci Rep

2023 May 11

Elahimanesh M, Najafi M.

Inflammatory bowel disease (IBD) is a long-term inflammatory immune-mediated gut illness with several extra-intestinal complications. The aims of this study were to identify a novel network-based meta-analysis approach on the basis of the combinations of the differentially expressed genes (DEGs) from microarray data, to enrich the functional modules from human protein-protein interaction (PPI) and gene ontology (GO) data, and to profile the ncRNAs on the genes involved in IBD. The gene expression profiles of GSE126124, GSE87473, GSE75214, and GSE95095 are obtained from the Gene Expression Omnibus (GEO) database based on the study criteria between 2017 and 2022. The DEGs were screened by the R software. DEGs were then used to examine gene ontology (GO) and the Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways. The ncRNAs including the miRNAs and ceRNAs were predicted on the PPIs visualized using Cytoscape. Enrichment analysis of genes with differential expression (n = 342) using KEGG and GO showed that the signaling pathways related with staphylococcus aureus and pertussis bacterial infections may stimulate the immune system and exacerbate IBD via the interaction with human proteins including Fibrinogen gamma chain (FGG), Keratin 10 (KRT10), and Toll like receptor 4 (TLR4). By building a ceRNA network, lncRNA XIST and NEAT1 were determined by affecting common miRNAs, hsa-miR-6875-5p, hsa-miR-1908-5p, hsa-miR-186-5p, hsa-miR-6763-5p, hsa-miR-4436a, and hsa-miR-520a-5p. Additionally, the chromosome regions including NM_001039703 and NM_006267, which produce the most potent circRNAs play a significant role in the ceRNA network of IBD. Also, we predicted the siRNAs that would be most effective against the bacterial genes in staphylococcus aureus and pertussis infections. These findings suggested that three genes (FGG, KRT10, and TLR4), six miRNAs (hsa-miR-6875-5p, hsa-miR-1908-5p, hsa-miR-186-5p, hsa-miR-4436a, hsa-miR-520a-5p, and hsa-miR-6763-5p), two lncRNAs (XIST and NEAT1), and chromosomal regions including NM_001039703 and NM_006267 with the production of the most effective circRNAs are involved in the ncRNA-associated ceRNA network of IBD. These ncRNA profiles are related to the described gene functions and may play therapeutic targets in controlling inflammatory bowel disease.

1199. The link between the sphingolipid rheostat and obstructive sleep apnea.

Sci Rep

2023 May 11

Horváth P, Büdi L, Hammer D

1200. REDbox: a comprehensive semantic framework for data collection and management in tuberculosis research.

Sci Rep

2023 May 11

Lima VC, Rijo RPCL, Bernardi FA

1201. 3D melanoma spheroid model for the development of positronium biomarkers.

Sci Rep

2023 May 11

Karimi H, Moskal P, Żak A

It was recently demonstrated that newly invented positronium imaging may be used for improving cancer diagnostics by providing additional information about tissue pathology with respect to the standardized uptake value currently available in positron emission tomography (PET). Positronium imaging utilizes the properties of positronium atoms, which are built from the electrons and positrons produced in the body during PET examinations. We hypothesized that positronium imaging would be sensitive to the in vitro discrimination of tumor-like three-dimensional structures (spheroids) built of melanoma cell lines with different cancer activities and biological properties. The lifetime of ortho-positronium (o-Ps) was evaluated in melanoma spheroids from two cell lines (WM266-4 and WM115) differing in the stage of malignancy. Additionally, we considered parameters such as the cell number, spheroid size and melanoma malignancy to evaluate their relationship with the o-Ps lifetime. We demonstrate pilot results for o-Ps lifetime measurement in extracellular matrix-free spheroids. With the statistical significance of two standard deviations, we demonstrated that the higher the degree of malignancy and the rate of proliferation of neoplastic cells, the shorter the lifetime of ortho-positronium. In particular, we observed the following indications encouraging further research: (i) WM266-4 spheroids characterized by a higher proliferation rate and malignancy showed a shorter o-Ps lifetime than WM115 spheroids characterized by a lower growth rate. (ii) Both cell lines showed a decrease in the lifetime of o-Ps after spheroid generation on day 8 compared to day 4 in culture, and the mean o-Ps lifetime was longer for spheroids formed from WM115 cells than for those formed from WM266-4 cells, regardless of spheroid age. The results of this study revealed that positronium is a promising biomarker that may be applied in PET diagnostics for the assessment of the degree of cancer malignancy.

1202. PeruNPDB: the Peruvian Natural Products Database for in silico drug screening.

Sci Rep

2023 May 10

Barazorda-Ccahuana HL, Ranilla LG, Candia-Puma MA

1203. Exploring the role of empathy in prolonged grief reactions to bereavement.

Sci Rep

2023 May 10

Yoshiike T, Benedetti F, Moriguchi Y

1204. A possible new cardiac heterogeneity as an arrhythmogenic driver.

Sci Rep

2023 May 10

Rabinovitch A, Rabinovitch R, Biton Y

Atrial fibrillation (AF) is the commonest cardiac arrhythmia, affecting 3 million people in the USA and 8 million in the EU (according to the European Society of Cardiology). So, why is it that even with the best medical care, around a third of the patients are treatment resistant. Extensive research of its etiology showed that AF and its mechanisms are still debatable. Some of the AF origins are ascribed to functional and ionic heterogeneities of the heart tissue and possibly to additional triggering agents. But, have all AF origins been detected? Are all accepted origins, in fact, arrhythmogenic? In order to study these questions and specifically to check our new idea of intermittency as an arrhythmogenesis agent, we chose to employ a mathematical model which was as simple as possible, but which could still be used to observe the basic network processes of AF development. At this point we were not interested in the detailed ionic propagations nor in the actual shapes of the induced action potentials (APs) during the AF outbreaks. The model was checked by its ability to exactly recapture the basic AF developmental stages known from experimental cardiac observations and from more elaborate mathematical models. We use a simple cellular automata 2D mathematical model of N × N matrices to elucidate the field processes leading to AF in a tissue riddled with randomly distributed heterogeneities of different types, under sinus node operation, simulated by an initial line of briefly stimulated cells inducing a propagating wave, and with or without an additional active ectopic action potential pulse, in turn simulated by a transitory operation of a specific cell. Arrhythmogenic contributions, of three different types of local heterogeneities in myocytes and their collaborations, in inducing AF are examined. These are: a heterogeneity created by diffuse fibrosis, a heterogeneity created by myocytes having different refractory periods, and a new heterogeneity type, created by intermittent operation of some myocytes. The developmental stages (target waves and spirals) and the different probabilities of AF occurring under each condition, are shown. This model was established as being capable of reproducing the known AF origins and their basic development stages, and in addition has shown: (1) That diffuse fibrosis on its own is not arrhythmogenic but in combination with other arrhythmogenic agents it can either enhance or limit AF. (2) In general, combinations of heterogeneities can act synergistically, and, most importantly, (3) The new type of intermittency heterogeneity proves to be extremely arrhythmogenic. Both the intermittency risk and the fibrosis role in AF generation were established. Knowledge of the character of these arrhythmogenesis agents can be of real importance in AF treatment.

1205. Electric fields in a counterflow nonpremixed flame: measurement and simulation.

Sci Rep

2023 May 10

Park J(#), Son J(#), Butterworth TD

1206. Identification of a genomic DNA sequence that quantitatively modulates KLF1 transcription factor expression in differentiating human hematopoietic cells.

Sci Rep

2023 May 10

Gnanapragasam MN(#), Planutis A(#), Glassberg JA

1207. Effects of exogenous glycine betaine and cycloleucine on photosynthetic capacity, amino acid composition, and hormone metabolism in Solanum melongena L.

Sci Rep

2023 May 10

Niu T, Zhang J, Li J

1208. Network pharmacology analysis reveals potential targets and mechanisms of proton pump inhibitors in breast cancer with diabetes.

Sci Rep

2023 May 10

Hu H(#), Wang H(#), Yang X

1209. Zn[Formula: see text]Ni[Formula: see text]Te semiconductor nanocrystals in transparent glass for optoelectronic device applications.

Sci Rep

2023 May 10

Mada R, Darabian H, Meruva S

Doping glass with semiconductors, particularly with nanostructured semiconductors, has attracted attention due to the large optical absorption cross-sections of the latter. Based on this property, Ni[Formula: see text] (5 wt%) doped phosphate glass and Zn[Formula: see text]Ni[Formula: see text]Te (x = 0.5, 1.0, 5.0 and 10.0 wt% of Ni[Formula: see text]) nanocrystals (NCs) doped phosphate glasses (GCs) were prepared by fusion method and subsequent heat treatment. Influence of Ni[Formula: see text] on structural, thermo-optical and third-order nonlinear optical properties have been analysed through various spectroscopic characterizations. The XRD pattern of the glass (G) exhibits the amorphous nature of the host material while GCs exhibit not only amorphous halo but also the presence of quantum dots (QDs) or nanocrystals (NCs) phases. TEM analysis of the studied GCs samples confirm the presence of quantum dots (QDs) and bulk NCs with an average diameter of approximately 4.2 [Formula: see text] 0.3 nm and 13.4 [Formula: see text] 0.2 nm, respectively. Several phosphate groups were observed and reported from Raman and FTIR-ATR spectra. The absorption band positions confirmed that Ni[Formula: see text] ions resemble to the octahedral symmetry. The intensity of absorption band around 1352 nm ([Formula: see text]T[Formula: see text](F) [Formula: see text] [Formula: see text]A[Formula: see text](F)) increased with the increase of Ni[Formula: see text] in GCs which is an indicative of the [Formula: see text]Ni[Formula: see text] coordination. The emission properties such as emission cross-sections ([Formula: see text]) full width at half maxima (FWHM) for the [Formula: see text]T[Formula: see text](D) [Formula: see text] [Formula: see text]T[Formula: see text](F) (visible) and [Formula: see text]A[Formula: see text](F) [Formula: see text] [Formula: see text]T[Formula: see text](F) (near-infrared) emission transitions were reported. Among the glass-containing semiconductor nanocrystals (GCs), the emission cross-sections in GC4 sample (x = 10% of Ni[Formula: see text]) are the largest for both the visible (11.88 [Formula: see text] 10[Formula: see text] cm[Formula: see text]) and infrared (0.98 [Formula: see text] 10[Formula: see text] cm[Formula: see text]) transitions. Thermal diffusivity (D), thermal conductivity (K) and temperature dependent optical path length change (ds/dT) were obtained through time-resolved thermal lens (TL) and thermal relaxation (TR) methods. The D and K parameters do not change significantly with increase of Ni[Formula: see text] ions (0.5-5%) in GCs. Nonlinear-refractive index and nonlinear absorption of the studied samples were also obtained using femtosecond Z-scan technique. The increase of nonlinear absorption coefficient ([Formula: see text]) is observed from GC2 (2.53 [Formula: see text] 10[Formula: see text] cm/W) to GC4 (7.98 [Formula: see text] 10[Formula: see text] cm/W). The GC4, sample with 10 wt% of Ni[Formula: see text], showed the lowest ds/dT (1.22 [Formula: see text] 10[Formula: see text] K[Formula: see text]) with good lasing (FOM and emission cross-sections) and nonlinear absorption properties suggesting that it can be a good candidate for visible-red emission light conversion in LED technology.

1210. Improved disinfection performance for 280 nm LEDs over 254 nm low-pressure UV lamps in community wastewater.

Sci Rep

2023 May 10

MacIsaac SA(#), Rauch KD(#), Prest T

1211. Label-free intraoperative nerve detection and visualization using ratiometric diffuse reflectance spectroscopy.

Sci Rep

2023 May 10

Throckmorton GA, Haugen E, Thomas G

1212. Efficient production of recombinant proteins in suspension CHO cells culture using the Tol2 transposon system coupled with cycloheximide resistance selection.

Sci Rep

2023 May 10

Yamaguchi K, Ogawa R, Tsukahara M

1213. The 15-year national trends of endocrine cancers incidence among Iranian men and women; 2005-2020.

Sci Rep

2023 May 10

Balajam NZ, Mousavian AH, Sheidaei A

Cancer is one of the important health problems in Iran, which is considered as the third cause of death. Endocrine cancers are rare but mostly curable. Thyroid cancer, the most common endocrine tumors, includes about one percent of malignant cancer. In this study, we examined the 15-year national trend of endocrine cancer incidence in Iranian men and women. The data in each province were evaluated based on age, gender, and cancer type according to International Classification of Disease Codes version 10 (ICD-10) from 2005 to 2020 in Iran. All data were obtained from the reports of the Statistics Center of Iran (SCI), 6 phases of the step-by-step approach to monitoring the risk factors of chronic diseases over 18 years old (STEPs), and 3 periods of the CASPIAN study (survey of non-communicable diseases in childhood and adolescence). Statistical analyzes and graph generation were done using R statistical software. Poisson regression with mixed effects was used for data modeling and incidence rate estimation. The incidence of thyroid gland malignancy is higher in women than in men. On the other hand, the incidence of adrenal gland cancer is slightly higher in men than in women. The same pattern is observed for other endocrine neoplasms and related structures. The incidence rate of these types of cancers has generally increased from 2005 to 2020 in Iran. This increase is more in women than in men. In addition, in the middle of the country, there is a strong region in terms of the occurrence of these types of cancers. The incidence rate in these provinces is relatively higher for both sexes and all studied periods. We conducted a study to observe the changing trends for various types of endocrine cancers over 15 years in men and women. Considering the increasing trend of thyroid cancers in Iran, therefore, creating essential policies for the management of these types of cancers for prevention, rapid diagnosis, and, timely treatment is particularly important.

1214. Unsupervised learning for prognostic validity in patients with chronic pain in transdisciplinary pain care.

Sci Rep

2023 May 10

Strigo IA, Simmons AN, Giebler J

1215. Analysis of biofilm and bacterial communities in the towel environment with daily use.

Sci Rep

2023 May 10

Kato H, Okino N, Kijitori H

1216. BIM-based digital platform and risk management system for mountain tunnel construction.

Sci Rep

2023 May 10

Liu N, Guo D, Song Z

1217. Picoplankton diversity in an oligotrophic and high salinity environment in the central Adriatic Sea.

Sci Rep

2023 May 10

Šantić D, Stojan I, Matić F

1218. Risk analysis for patients with arterial thromboembolic events after intravitreal ranibizumab or aflibercept injections.

Sci Rep

2023 May 10

Chou YI(#), Chang HY(#), Lin MY

1219. Muscle quality determined by computed tomography predicts short-term and long-term survival after liver transplantation.

Sci Rep

2023 May 10

Molwitz I(#), Recklies F(#), Stark M

1220. Anthropogenic change decouples a freshwater predator's density feedback.

Sci Rep

2023 May 10

Sinclair JS, Briland R, Fraker ME

1221. Predicting tumor recurrence on baseline MR imaging in patients with early-stage hepatocellular carcinoma using deep machine learning.

Sci Rep

2023 May 10

Kucukkaya AS, Zeevi T, Chai NX

1222. Climate change decouples dominant tree species in African savannas.

Sci Rep

2023 May 10

Mtsetfwa FP, Kruger L, McCleery RA.

1223. The impact of surgical volume on hospital ranking using the standardized infection ratio.

Sci Rep

2023 May 10

Ye S, Li D, Yu T

1224. Morphological and morphometric study of the scapulae of Korean wild deer.

Sci Rep

2023 May 10

Kang MC(#), Kwon J(#), Kim IS

Korean water deer (Hydropotes inermis argyropus; Heude, 1884) and Siberian roe deer (Capreolus pygargus; Pallas, 1771) are Korean wild deer classified in the tribe Capreolini. C. pygargus in Korea were previously considered a single species; however, it was recently suggested that roe deer living on Jeju Island (Jeju roe deer; Capreolus pygargus jejuensis) is a distinct subspecies from roe deer living on the Korean peninsula (mainland roe deer; Capreolus pygargus tianschanicus) based on several studies demonstrating genetic and morphological features. In this study, we suggests that the scapular morphology and osteometric data can be used for interspecies discrmination between Korean wild deer. To compare the morphological characteristics of scapula among the three groups of deer, we analyzed the features and nine osteomorphological measurements of 31 H. i. argyropus (14 males and 17 females), 18 C. p. jejuensis (4 males and 14 females), and 23 C. p. tianschanicus (16 females and 7 males). The estimated ages of the deer were over 32-35 months. Data were analyzed by one-way repeated measures analysis of variance with post hoc Duncan test and discriminant functional analysis (DFA). H. i. argyropus and C. p. tianschanicus had the smallest and largest scapulae, respectively. The scapulae of the three Korean wild deer had a similar triangular shape, which was obscured by the tuber of the scapular spine, pointed acromion, broad infraspinous fossa, narrow supraspinous fossa, and partial ossification of scapular cartilage in older deer. H. i. argyropus had certain distinctive features, including a caudally pointed acromion, a notch between the supraglenoid tubercle and glenoid cavity (NBSG), a glenoid notch, and no sexual dimorphism, except for the longest dorsal length (Ld) and the scapular index (SI). C. p. jejuensis had a larger scapular index (SI) (61.74 ± 0.74%), compared with the SIs of H. i. argyropus and C. p. tianschanicus. The unique features of the scapula in C. p. jejuensis include its S-shaped cranial border. The C. p. jejuensis had a cranially pointed acromion, less frequent presence of glenoid notch and NBSG, short length of supraglenoid tubercle, and no sexual dimorphism. The C. p. tianschanicus had elevated cranial margin of the glenoid cavity, and frequent presence of glenoid notch and NBSG, similar to the H. i. argyropus. Similar to C. p. jejuensis, C. p. tianschanicus had a cranially pointed acromion. However, sexual dimorphism was observed in C. p. tianschanicus. DFA using osteometric data showed 97.22% of specimens were classified correctly into their species, meaning the osteometric parameters can be used for interspecies discrimination of Korean wild deer. Our findings indicate that the scapular morphologies of the three Korean wild deer have certain similarities and differences, suggesting that C. p. jejuensis are distinct from C. p. tianschanicus.

1225. Studying the mechanism and kinetics of fuel desulfurization using CexOy/NiOx piezo-catalysts as a new low-temperature method.

Sci Rep

2023 May 10

Ahmed SS, Amiri O, Rahman KM

1226. RNA-sequencing transcriptome analysis of Avicennia marina (Forsk.) Vierh. leaf epidermis defines tissue-specific transcriptional response to salinity treatment.

Sci Rep

2023 May 10

Li H, Lv CT, Li YT

1227. A kinetic-based stopped-flow DPPH(•) method.

Sci Rep

2023 May 10

Angeli L, Morozova K, Scampicchio M.

1228. Antimicrobial properties of promising Zn-Fe based layered double hydroxides for the disinfection of real dairy wastewater effluents.

Sci Rep

2023 May 10

Abdel Aziz SAA, GadelHak Y, Mohamed MBED

1229. Deep ocean water alters the cholesterol and mineral metabolism of squid Todarodes pacificus and suppresses its weight loss.

Sci Rep

2023 May 10

Hatano K(#), Yoshida MA(#), Hirayama J

1230. Synthesis of L-methionine-loaded chitosan nanoparticles for controlled release and their in vitro and in vivo evaluation.

Sci Rep

2023 May 10

Nuzaiba PM(#), Gupta S(#), Gupta S

Therapeutically popular controlled release-enabling technology has forayed into the nutrition sector. Polymer coated forms of L-methionine used in soy protein diets, and its intermediate metabolite, S-adenosyl-L-methionine, used in myriad of medical conditions have proved more efficacious over (highly catabolized) free forms. In this premier study, L-methionine-loaded chitosan nanoparticles (M-NPs) were synthesized using ionic gelation method and their efficacy was evaluated. Biophysical characterization of the NPs was done using a Nanopartica SZ 100 analyser, transmission electron microscopy, and Fourier transform infrared spectroscopy. The M-NPs were spherical and smooth and 218.9 ± 7.4 nm in size and in vitro testing confirmed the controlled release of methionine. A 60-days feeding trial in L. rohita fish fingerlings was conducted. A basal diet suboptimal (0.85%) in methionine was provided with one of the supplements as under: none (control), 0.8% chitosan NPs (0.8% NPs), 1.2% L-methionine (1.2% M) (crystalline free form), 0.6% M-NPs and 1.2% M-NPs. While the addition of 0.6% M-NPs to the basal diet complemented towards meeting the established dietary requirement and resulted in significantly highest (P < 0.05) growth and protein efficiency and sero-immunological test scores (serum total protein, serum globulin, serum albumin: globulin ratio, phagocytic respiratory burst/NBT reduction and lysozyme activity), 1.2% supplementation in either form (free or nano), for being 0.85% excess, was counterproductive. Liver transaminases and dehydrogenases corroborated enhanced growth. It was inferred that part of the methionine requirement in nano form (M-NPs) can confer intended performance and health benefits in animals relying on plant proteins-based diets limiting in this essential amino acid. The study also paves the way for exploring chitosan NPs-based sustained delivery of amino acids in human medical conditions.

1231. Traumatic brain injury related deaths in residents and non-residents of 30 European countries: a cross-sectional study.

Sci Rep

2023 May 10

Sivco P, Plancikova D, Melichova J

The incidence and mortality of traumatic brain injuries (TBI) among non-residents to countries where they occur remains unknown, warranting epidemiological research. Epidemiological data are key to inform prevention and public health policies related to TBI, as well as to help promote safe travelling practice. The aim of this study was to analyse the epidemiological patterns of TBI-related deaths among residents and non-residents in 30 European countries in 2015 using standardised European level data on causes of death. A large-scale cross-sectional study analysing TBI-related deaths in 30 European countries in 2015 among residents and non-residents to the country of occurrence of the death was conducted. Data from death certificates collected on European level by Eurostat were used to calculate the numbers of TBI-related deaths and estimate crude and age-standardised mortality rates. Rates were stratified by country, sex, age-group and by resident status. External causes of the injury were determined using the provided ICD-10 codes. 40,087 TBI-related deaths were identified; overall about 3% occurred among non-residents with highest proportions in Turkey (11%), Luxembourg (9%) and Cyprus (5%). Taking into account tourism intensity in the countries, Bulgaria, Greece and Austria showed highest rates of TBI-related deaths in non-residents: 0.7,0.5 and 0.5 per million overnight stays, respectively. The pooled age-standardised TBI-related mortality in non-residents was 0.2 (95% CI 0.1-0.3), among residents 10.4 (95% CI 9.4-11.5) per 100,000. In non-residents, TBI-related deaths were shifted to younger populations (86% in < 35 years); in non-residents 78% were 15-64 years old. Falls were predominant among residents (47%), and traffic accidents among non-residents (36%). Male:female ratio was higher among non-residents (3.9), compared to residents (2.1). Extrapolating our findings, we estimate that annually 1022 TBI-related deaths would occur to non-residents in the EU-27 + UK and 1488 in Europe as a continent. We conclude, that the primary populations at risk of TBI-related deaths in European countries differ in several characteristics between residents and non-residents to the country of the occurrence of death, which warrants for different approaches in prevention and safety promotion. Our findings suggest that TBI occurring in European countries among non-residents present a problem worthy of attention from public health and travel medicine professionals and should be further studied.

1232. Intriguing physicochemical properties and impact of co-dopants on N-doped graphene oxide based ZnS nanowires for photocatalytic application.

Sci Rep

2023 May 10

Dake DV, Raskar ND, Mane VA

1233. Detection of high-risk Human Papillomavirus in prostate cancer from a UK based population.

Sci Rep

2023 May 10

Ahmed MY(#), Salman NA(#), Sandhu S

1234. Photogrammetry as a promising tool to unveil marine caves' benthic assemblages.

Sci Rep

2023 May 10

Pulido Mantas T, Roveta C, Calcinai B

1235. Sound waves for solving the problem of recrystallization in cryopreservation.

Sci Rep

2023 May 10

Alcalá E, Encabo L, Barroso F

1236. Dynamic obstacle detection method based on U-V disparity and residual optical flow for autonomous driving.

Sci Rep

2023 May 10

Yuan J, Jiang T, He X

1237. Prediction of SMEs' R&D performances by machine learning for project selection.

Sci Rep

2023 May 10

Yoo HS, Jung YL, Jun SP.

1238. A nursing care-sensitive patient satisfaction measure in older patients.

Sci Rep

2023 May 10

Goes M, Oliveira H, Lopes M

1239. Associations between circulating microRNAs and lipid-rich coronary plaques measured with near-infrared spectroscopy.

Sci Rep

2023 May 10

Sæther JC, Vesterbekkmo EK, Taraldsen MD

1240. Assessing the climate change mitigation potential from food waste composting.

Sci Rep

2023 May 10

Pérez T, Vergara SE, Silver WL.

1241. Building performance simulations can inform IoT privacy leaks in buildings.

Sci Rep

2023 May 10

Wang A, Campbell B, Heydarian A.

1242. Cortical suspensory button fixation has superior biomechanical properties to knotless anchor suture in anterior cruciate ligament repair: a biomechanical study.

Sci Rep

2023 May 10

Itthipanichpong T, Thamrongskulsiri N, Tangpornprasert P

1243. Clinical implication of tissue carcinoembryonic antigen expression in association with serum carcinoembryonic antigen in colorectal cancer.

Sci Rep

2023 May 10

Aldilaijan AF(#), Kim YI(#), Kim CW

1244. Possible involvement of silent mutations in cancer pathogenesis and evolution.

Sci Rep

2023 May 10

Kikutake C, Suyama M.

1245. Analysis and functional relevance of the chaperone TRAP-1 interactome in the metabolic regulation and mitochondrial integrity of cancer cells.

Sci Rep

2023 May 10

Dharaskar SP, Paithankar K, Amere Subbarao S.

1246. Numerical study and experimental validation of the size effect of smooth and mode I cracked semi-circular bend specimens.

Sci Rep

2023 May 10

Mousa S, Mutnbak M, Saba AM

1247. A new correlation belief function in Dempster-Shafer evidence theory and its application in classification.

Sci Rep

2023 May 10

Tang Y, Zhang X, Zhou Y

1248. Fim3-dependent autoagglutination of Bordetella pertussis.

Sci Rep

2023 May 10

Otsuka N, Koide K, Goto M

1249. A system that delivers an antioxidant to mitochondria for the treatment of drug-induced liver injury.

Sci Rep

2023 May 10

Hibino M, Maeki M, Tokeshi M

1250. Selecting antibacterial aptamers against the BamA protein in Pseudomonas aeruginosa by incorporating genetic algorithm to optimise computational screening method.

Sci Rep

2023 May 10

Selvam R, Lim IHY, Lewis JC

1251. Anti-proliferative potential and oxidative reactivity of thermo-oxidative degradation products of stigmasterol and stigmasteryl esters for human intestinal cells.

Sci Rep

2023 May 1

Kasprzak M, Rudzińska M, Juzwa W

1252. Reproductives signature revealed by protein profiling and behavioral bioassays in termite.

Sci Rep

2023 May 1

Ruhland F, Gabant G, Toussaint T

1253. Respiratory entrainment of the locus coeruleus modulates arousal level to avoid physical risks from external vibration.

Sci Rep

2023 May 1

Iwamoto M, Yonekura S, Atsumi N

1254. Personality traits and dimensions of mental health.

Sci Rep

2023 May 1

Kang W, Steffens F, Pineda S

Individuals are different in a relatively constant pattern of thoughts, feeling, and behaviors, which are called personality traits. Mental health is a condition of well-being in which people may reach their full potential and deal effectively with stress, work efficiently, and contribute to their communities. Indeed, the link between personality and mental health as indicated by the 12-item version of the general health questionnaires (GHQ-12) has been well-established according to evidence found by decades of research. However, the GHQ-12 comprises many questions asking about different dimensions of mental health. It is unclear how personality traits relate to these dimensions of mental health. In this paper, we try to address this question. We analyzed data from 12,007 participants from the British Household Panel Study (BHPS) using a confirmatory factor analysis (CFA) and generalized linear models. We replicated the factor structure of GHQ-12 labeled as GHQ-12A (social dysfunction & anhedonia; 6 items), GHQ-12B (depression & anxiety; 4 items), and GHQ-12C (loss of confidence; 2 items). Moreover, Neuroticism was positively related to all dimensions of mental health issues, Extraversion was negatively related to GHQ-12A (social dysfunction & anhedonia) and GHQ-12B (depression & anxiety), Agreeableness and Conscientiousness were negatively related to GHQ-12A (social dysfunction & anhedonia) and GHQ-12C (loss of confidence), and Openness was negatively related to GHQ-12B (depression & anxiety). These results contribute to theories including the predisposition/vulnerability model, complication/scar model, pathoplasty/exacerbation model, and the spectrum model, which propose that personality traits are linked to mental health and explained possible reasons. Psychologists may use results from this study to identify individuals who may be at high risk of developing various non-psychiatric mental health issues and intervene to avoid negative outcomes.

1255. Multi-criteria decision-making for prioritizing photocatalytic processes followed by TiO(2)-MIL-53(Fe) characterization and application for diazinon removal.

Sci Rep

2023 May 1

Barjasteh-Askari F, Nabizadeh R, Najafpoor A

1256. Factors predicting medication adherence among Omani patients with chronic diseases through a multicenter cross-sectional study.

Sci Rep

2023 May 1

Al-Noumani H, Alharrasi M, Lazarus ER

Management of chronic diseases is complex and requires a long-term commitment to therapeutic medications. However, medication adherence is suboptimal. There is limited understanding of factors predicting medication adherence in chronic diseases in Oman. This study aimed to examine predictors of medication adherence (i.e. patient clinical and demographic data, patient-physician relationship, health literacy, social support) among Omani patients with chronic diseases. This study used a cross-sectional correlation design. Data were collected from 800 participants using convenience sampling between December 2019 and April 2020. Arabic versions of the Brief Health Literacy Screening tool, Multidimensional Scale of Perceived Social Support, Patient-Doctor Relationship Questionnaire, and Adherence in Chronic Disease Scale were used to measure study variables. Descriptive statistics, independent t tests, one-way ANOVA, Pearson correlations, and multivariate linear regression were used for analysis. The study found that factors such as the patient-physician relationship, social support, disease duration, employment status, and medication frequency significantly predicted medication adherence. Medication adherence was higher among those who were unemployed, had a better patient-physician relationship, and greater social support. However, medication adherence was lower with longer disease duration and higher daily medication frequency. Additionally, medication adherence was positively associated with perceived social support and the patient-physician relationship, but not with health literacy. In conclusion, the study reveals that patient characteristics, social support, and patient-physician relationships are key factors in predicting medication adherence in patients with chronic diseases in the Middle East. It emphasizes the importance of improving these aspects, considering factors like employment status, disease duration, and medication frequency, and enhancing healthcare provider-patient relationships and social support systems to boost adherence.

1257. Plasmodium falciparum gametocyte carriage in longitudinally monitored incident infections is associated with duration of infection and human host factors.

Sci Rep

2023 May 1

Andolina C(#), Ramjith J(#), Rek J

1258. N,N-dimethylacetamide targets neuroinflammation in Alzheimer's disease in in-vitro and ex-vivo models.

Sci Rep

2023 May 1

Wei ZH, Koya J, Acharekar N

1259. The Mc4r gene is responsible for the development of experimentally induced testicular teratomas.

Sci Rep

2023 May 1

Seki S(#), Ohura K(#), Miyazaki T

1260. β-adrenergic receptor agonist promotes ductular expansion during 3,5-diethoxycarbonyl-1,4-dihydrocollidine-induced chronic liver injury.

Sci Rep

2023 May 1

Tanimizu N, Ichinohe N, Mitaka T.

1261. High side-mode suppression ratio with a Vernier effect single-mode laser using triple coupled microrings.

Sci Rep

2023 May 1

Jahangiri M, Moradiani F, Parsanasab GM

1262. Automated code compliance checking research based on BIM and knowledge graph.

Sci Rep

2023 May 1

Peng J, Liu X.

1263. Monitoring resistance to methomyl and synergism in the non-target Musca domestica from cotton fields of Punjab and Sindh provinces, Pakistan.

Sci Rep

2023 May 1

Khan HAA.

Insecticides are an integral part of most of the cropping systems worldwide; however, these usually exert negative impact on the environment and non-target insects as well. Non-target insects are prone to develop resistance to insecticides due to prolonged and repeated lethal and sublethal exposures. Musca domestica is a common non-target, pollinator and nectar feeder species in cotton ecosystem, besides its status as a public health pest in human habitations. In the present work, resistance to methomyl, one of the major insecticides used for cotton pest management, was assessed in 20 M. domestica strains from the major cotton producing areas of the Punjab and Sindh provinces of Pakistan. The results revealed that toxicity values of methomyl for Punjabi and Sindhi strains ranged from 28.07 to 136.16 µg fly-1 and 29.32 to 136.87 µg fly-1, respectively. Among Punjabi strains, D.G. Khan, Lodhran, Bahawalpur, Toba Tek Singh, Bahawalnagar, Rajanpur and Jhang strains exhibited very high levels of resistance (RR > 100) to methomyl; Bhakkar, Kasur, Vehari, Layyah, Muzaffargarh and R.Y. Khan showed high resistance (RR = 51-100 fold), while the Mianwali strain showed a moderate level of resistance to methomyl (RR = 36.45 fold). In case of Sindhi strains, very high levels of resistance (> 100 fold) were reported for Sukkar and Sanghar strains, high levels of resistance (RR 51-100 fold) for Khairpur, Jamshoro and Ghotki, and moderate resistance to methomyl (38.08 fold) in the Dadu strain. There was a significant synergism of methomyl toxicity in all field strains when methomyl bioassayed along with piperonyl butoxide (PBO) and S,S,S-tributylphosphorotrithioate (DEF) providing clues of metabolic-based mechanisms of resistance to methomyl. In conclusion, insecticides used in crop farming can cause resistance development in non-target M. domestica. It is necessary to adopt the pest management activities that are safe for the environment and non-target insect species.

1264. A local translation program regulates centriole amplification in the airway epithelium.

Sci Rep

2023 May 1

Liu H(#), Li H(#), Jiang Z

1265. Nonlinear stability of two dusty magnetic liquids surrounded via a cylindrical surface: impact of mass and heat spread.

Sci Rep

2023 May 1

Moatimid GM, Mostafa DM.

The current article examines a nonlinear axisymmetric streaming flow obeying the Rivlin-Ericksen viscoelastic model and overloaded by suspended dust particles. The fluids are separated by an infinite vertical cylindrical interface. A uniform axial magnetic field as well as mass and heat transmission (MHT) act everywhere the cylindrical flows. For the sake of simplicity, the viscous potential theory (VPT) is adopted to ease the analysis. The study finds its significance in wastewater treatment, petroleum transport as well as various practical engineering applications. The methodology of the nonlinear approach is conditional primarily on utilizing the linear fundamental equations of motion along with the appropriate nonlinear applicable boundary conditions (BCs). A dimensionless procedure reveals a group of physical dimensionless numerals. The linear stability requirements are estimated by means of the Routh-Hurwitz statement. The application of Taylor's theory with the multiple time scales provides a Ginzburg-Landau equation, which regulates the nonlinear stability criterion. Therefore, the theoretical nonlinear stability standards are determined. A collection of graphs is drawn throughout the linear as well as the nonlinear approaches. In light of the Homotopy perturbation method (HPM), an estimated uniform solution to the surface displacement is anticipated. This solution is verified by means of a numerical approach. The influence of different natural factors on the stability configuration is addressed. When the density number of the suspended inner dust particles is less than the density number of the suspended outer dust particles, and vice versa, it is found that the structure is reflected to be stable. Furthermore, as the pure outer viscosity of the liquid increases, the stable range contracts, this means that this parameter has a destabilizing effect. Additionally, the magnetic field and the transfer of heat don't affect the nature of viscoelasticity.

1266. Plant extracts have dual mechanism on the protection against dentine erosion: action on the dentine substrate and modification of the salivary pellicle.

Sci Rep

2023 May 1

Niemeyer SH, Baumann T, Lussi A

1267. Type III Gustilo-Anderson open fracture does not justify routine prophylactic Gram-negative antibiotic coverage.

Sci Rep

2023 May 1

Suzuki T, Inui T, Sakai M

1268. Adenylyl cyclase 6 plays a minor role in the mouse inner ear and retina.

Sci Rep

2023 May 1

Mathur PD(#), Zou J(#), Neiswanger G