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1. Effect of Limosilactobacillus fermentum 332 on physicochemical characteristics, volatile flavor components, and Quorum sensing in fermented sausage.

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2023 Mar 9

Gu Y(#), Qiao R(#), Jin B

2. Novel method of differentiating human induced pluripotent stem cells to mature cardiomyocytes via Sfrp2.

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2023 Mar 9

Hsueh YC, Pratt RE, Dzau VJ

3. Diversity of life history and population connectivity of threadfin fish Eleutheronema tetradactylum along the coastal waters of Southern China.

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2023 Mar 9

Xuan Z, Wang WX.

4. Carleman linearization approach for chemical kinetics integration toward quantum computation.

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2023 Mar 9

Akiba T, Morii Y, Maruta K.

5. Preparation of Fe(3)O(4)/vine shoots derived activated carbon nanocomposite for improved removal of Cr(VI) from aqueous solutions.

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2023 Mar 9

Bagherzadeh M, Aslibeiki B, Arsalani N.

6. A pilot study on lengthening potentials and biomechanical effects of double and triple hemisection on tendon with slide lengthening.

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2023 Mar 9

Wang T, Yu H, Tian GF

7. Motor unit number index (MUNIX) loss of 50% occurs in half the time of 50% functional loss according to the D50 disease progression model of ALS.

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2023 Mar 9

Ebersbach T(#), Roediger A(#), Steinbach R

8. Projection of August 2021 pumice dispersion from the Fukutoku-Oka-no-Ba eruption in the western North Pacific.

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2023 Mar 9

Chang YK, McIntosh IM, Miyama T

9. Kelvin-Helmholtz instability in a compressible dust fluid flow.

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2023 Mar 9

Kumar K, Bandyopadhyay P, Singh S

10. A comparative analysis of clinicopathological features and survival between pre and postmenopausal breast cancer from an Indian cohort.

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2023 Mar 9

Nimbalkar VP, Rajarajan S, V P S

11. Quantum deep learning by sampling neural nets with a quantum annealer.

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2023 Mar 9

Higham CF, Bedford A.

12. Machine learning accelerated approach to infer nuclear magnetic resonance porosity for a middle eastern carbonate reservoir.

Sci Rep

2023 Mar 9

Mustafa A, Tariq Z, Mahmoud M

Carbonate rocks present a complicated pore system owing to the existence of intra-particle and interparticle porosities. Therefore, characterization of carbonate rocks using petrophysical data is a challenging task. Conventional neutron, sonic, and neutron-density porosities are proven to be less accurate as compared to the NMR porosity. This study aims to predict the NMR porosity by implementing three different machine learning (ML) algorithms using conventional well logs including neutron-porosity, sonic, resistivity, gamma ray, and photoelectric factor. Data, comprising 3500 data points, was acquired from a vast carbonate petroleum reservoir in the Middle East. The input parameters were selected based on their relative importance with respect to output parameter. Three ML techniques such as adaptive neuro-fuzzy inference system (ANFIS), artificial neural network (ANN), and functional network (FN) were implemented for the development of prediction models. The model's accuracy was evaluated by correlation coefficient (R), root mean square error (RMSE), and average absolute percentage error (AAPE). The results demonstrated that all three prediction models are reliable and consistent exhibiting low errors and high 'R' values for both training and testing prediction when related to actual dataset. However, the performance of ANN model was better as compared to other two studied ML techniques based on minimum AAPE and RMSE errors (5.12 and 0.39) and highest R (0.95) for testing and validation outcome. The AAPE and RMSE for the testing and validation results were found to be 5.38 and 0.41 for ANFIS and 6.06 and 0.48 for FN model, respectively. The ANFIS and FN models exhibited 'R' 0.937 and 0.942, for testing and validation dataset, respectively. Based on testing and validation results, ANFIS and FN models have been ranked second and third after ANN. Further, optimized ANN and FN models were used to extract explicit correlations to compute the NMR porosity. Hence, this study reveals the successful applications of ML techniques for the accurate prediction of NMR porosity.

13. Estimation of interface frictional anisotropy between sand and snakeskin-inspired surfaces.

Sci Rep

2023 Mar 9

Lee SH, Nawaz MN, Chong SH.

14. Association between exercise habit changes and incident dementia after ischemic stroke.

Sci Rep

2023 Mar 9

Cheon DY(#), Han KD(#), Kim CH

15. Effects of UV-B radiation on epiphytic bacterial communities on male and female Sargassum thunbergii.

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2023 Mar 9

Wang J, Yang Z, Lu P

The effects of increased UV-B radiation on macroalgae have been widely studied, but knowledge concerning the response of communities of algal epiphytic bacteria to increased UV-B radiation and differences between male and female algae is still lacking. Via 16S rDNA high-throughput sequencing technology, changes in the epiphytic bacterial communities on male and female S. thunbergii under increased UV-B radiation were studied in the lab. Under different UV-B radiation intensities, although the α diversity and community composition of epiphytic bacteria changed little, the β diversity indicated that the community structure of bacteria on S. thunbergii was obviously clustered, and the relative abundance of dominant bacteria and indicator species changed considerably. There were unique bacteria in each experimental group, and the bacteria whose abundance obviously changed were members of groups related to environmental resistance or adaptability. The variation in the abundance of epiphytic bacteria was different in male and female S. thunbergii, and the bacteria whose abundance greatly changed were mainly related to algal growth and metabolism. The abundance of genes with predicted functions related to metabolism, genetic information processing, environmental adaptation and infectious diseases changed with increased UV-B radiation, and those variations differed between epiphytic bacteria on male and female S. thunbergii. This study found that the algal epiphytic bacteria were influenced by the increase in UV-B radiation and underwent certain adaptations through adjustments to community structure and function, and this response was also affected by the sex of the macroalgae. These results are expected to serve as experimental basis and provide reference for further understanding of the response of algae epiphytic bacteria to enhanced UV-B radiation caused by the thinning of the ozone layer and the resulting changes in the relationship between algae and bacteria, which may change the community of the marine ecosystem and affect important marine ecological process.

16. Designing an integrated blockchain-enabled supply chain network under uncertainty.

Sci Rep

2023 Mar 9

Babaei A, Khedmati M, Akbari Jokar MR

17. New light on the photocatalytic performance of NH(4)V(4)O(10) and its composite with rGO.

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2023 Mar 9

Nadolska M, Szkoda M, Trzciński K

18. Decreased Paneth cell α-defensins promote fibrosis in a choline-deficient L-amino acid-defined high-fat diet-induced mouse model of nonalcoholic steatohepatitis via disrupting intestinal microbiota.

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2023 Mar 9

Nakamura S, Nakamura K, Yokoi Y

19. Environmental effects on brain functional networks in a juvenile twin population.

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2023 Mar 9

Tassi E(#), Maggioni E(#), Mauri M

20. Analysis of sequence diversity in Plasmodium falciparum glutamic acid-rich protein (PfGARP), an asexual blood stage vaccine candidate.

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2023 Mar 9

Rojrung R, Kuamsab N, Putaporntip C

21. Modelling physical contacts to evaluate the individual risk in a dense crowd.

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2023 Mar 9

Wang C, Shen L, Weng W.

22. Sinomenine ameliorates adjuvant-induced arthritis by inhibiting the autophagy/NETosis/inflammation axis.

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2023 Mar 9

Jiang H(#), Lu Q(#), Xu J(#)

Studies have found that neutrophil extracellular traps (NETs) which are the specific dying form of neutrophil upon activation have fundamental role in the rheumatoid arthritis onset and progression. The purpose of this study was to explore the therapeutic effect of Sinomenine on adjuvant-induced arthritis in mice, and the neutrophil activities regulated by Sinomenine. The rheumatoid arthritis model was established by local injection of adjuvant and the Sinomenine treatment was administered orally for 30 days, during which, arthritic scores were evaluated and the joint diameter was measured to determine disease progression. The joint tissues and serum were acquired for further tests after sacrifice. Cytometric beads assay was performed to measure the concentration of cytokines. For paraffin-embedded ankle tissues, hematoxylin and erosin staining and Safranin O-fast staining were adopted to monitor the tissue changes of joint. In order to analyze the inflammation, NETs and autophagy of neutrophils in vivo, immunohistochemistry assays were applied to detect the protein expression levels in the local joints. To describe the effect brought by Sinomenine on inflammation, autophagy and NETs in vitro, the western blotting and the immunofluorescence assays were performed. The joint symptoms of the adjuvant induced arthritis were alleviated by the Sinomenine treatment significantly in terms of the ankle diameter and scores. The improvement of local histopathology changes and decrease of inflammatory cytokines in the serum also confirmed the efficacy. The expression levels of interleukin-6, P65 and p-P65 in the ankle areas of mice were remarkably reduced by Sinomenine. Compared with the model group, the decreased expression levels of lymphocyte antigen 6 complex and myeloperoxidase in the Sinomenine treating group showed the inhibitory effect of Sinomenine on the neutrophil migration. The expression of protein arginine deiminase type 4 (PAD4), ctrullinated histone H3 (CitH3) and microtubule-associated protein 1 light chain 3B (LC3B) had the similar tendency. Upon activation of lipopolysaccharide (LPS) in vitro, Sinomenine suppressed the phosphorylation of P65, extracellular signal-regulated kinase (ERK) and P38 of neutrophil. Meanwhile, Sinomenine inhibited NETs formation induced by phorbol 12-myristate 13-acetate (PMA), which were demonstrated by the decreased expression of neutrophil elastase (NE), PAD4 and CitH3. Sinomenine also inhibited PMA-induced autophagy in vitro based on the changes of Beclin-1 and LC3B. Sinomenine has good efficacy in treating adjuvant induced arthritis via regulating neutrophil activities. Apart from inhibiting activation of nuclear factor kappa-B (NF-κB) and mitogen-activated protein kinase (MAPK) pathways, the mechanism includes suppression of NETs formation via autophagy inhibition.

23. A prosocial fake news intervention with durable effects.

Sci Rep

2023 Mar 9

Orosz G, Paskuj B, Faragó L

24. ECG-guided non-invasive estimation of pulmonary congestion in patients with heart failure.

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2023 Mar 9

Raghu A, Schlesinger D, Pomerantsev E

Quantifying hemodynamic severity in patients with heart failure (HF) is an integral part of clinical care. A key indicator of hemodynamic severity is the mean Pulmonary Capillary Wedge Pressure (mPCWP), which is ideally measured invasively. Accurate non-invasive estimates of the mPCWP in patients with heart failure would help identify individuals at the greatest risk of a HF exacerbation. We developed a deep learning model, HFNet, that uses the 12-lead electrocardiogram (ECG) together with age and sex to identify when the mPCWP > 18 mmHg in patients who have a prior diagnosis of HF. The model was developed using retrospective data from the Massachusetts General Hospital and evaluated on both an internal test set and an independent external validation set, from another institution. We developed an uncertainty score that identifies when model performance is likely to be poor, thereby helping clinicians gauge when to trust a given model prediction. HFNet AUROC for the task of estimating mPCWP > 18 mmHg was 0.8 [Formula: see text] 0.01 and 0.[Formula: see text] 0.01 on the internal and external datasets, respectively. The AUROC on predictions with the highest uncertainty are 0.50 [Formula: see text] 0.02 (internal) and 0.[Formula: see text] 0.04 (external), while the AUROC on predictions with the lowest uncertainty were 0.86 ± 0.01 (internal) and 0.82 ± 0.01 (external). Using estimates of the prevalence of mPCWP > 18 mmHg in patients with reduced ventricular function, and a decision threshold corresponding to an 80% sensitivity, the calculated positive predictive value (PPV) is 0.[Formula: see text] 0.01when the corresponding chest x-ray (CXR) is consistent with interstitial edema HF. When the CXR is not consistent with interstitial edema, the estimated PPV is 0.[Formula: see text] 0.02, again at an 80% sensitivity threshold. HFNet can accurately predict elevated mPCWP in patients with HF using the 12-lead ECG and age/sex. The method also identifies cohorts in which the model is more/less likely to produce accurate outputs.

25. Risk and prognosis of secondary esophagus cancer after radiotherapy for breast cancer.

Sci Rep

2023 Mar 9

Sun Q(#), Chen Y(#), Li T

26. Non-optimal ambient temperatures aggravate insecticide toxicity and affect honey bees Apis mellifera L. gene regulation.

Sci Rep

2023 Mar 9

Alburaki M, Madella S, Cook SC.

In this study, we conducted a transcriptional analysis of five honey bee genes to examine their functional involvement vis-à-vis ambient temperatures and exposure to imidacloprid. In a 15-day cage experiment, three cohorts of one-day-old sister bees emerged in incubators, were distributed into cages, and maintained at three different temperatures (26 °C, 32 °C, 38 °C). Each cohort was fed a protein patty and three concentrations of imidacloprid-tainted sugar (0 ppb, 5 ppb and 20 ppb) ad libitum. Honey bee mortality, syrup and patty consumption were monitored daily over 15 days. Bees were sampled every three days for a total of five time points. RT-qPCR was used to longitudinally assess gene regulation of Vg, mrjp1, Rsod, AChE-2 and Trx-1 using RNA extracted from whole bee bodies. Kaplan-Meier models show that bees kept at both non-optimal temperatures (26 °C and 38 °C) were more susceptible to imidacloprid, with significantly higher mortality (P < 0.001 and P < 0.01, respectively) compared to the control. At 32 °C, no differences in mortality (P = 0.3) were recorded among treatments. In both imidacloprid treatment groups and the control, the expression of Vg and mrjp1 was significantly downregulated at 26 °C and 38 °C compared to the optimal temperature of 32 °C, indicating major influence of ambient temperature on the regulation of these genes. Within the ambient temperature groups, both imidacloprid treatments exclusively downregulated Vg and mrjp1 at 26 °C. AChE-2 and the poorly characterized Rsod gene were both consistently upregulated at the highest temperature (38 °C) compared to the ideal temperature (32 °C) in all treatment groups. Trx-1 showed no effect to both temperature and imidacloprid treatments and was regulated in an age-related manner. Overall, our results indicate that ambient temperatures amplify imidacloprid toxicity and affect honey bee gene regulation.

27. Design of intelligent module design for humanoid translation robot by combining the deep learning with blockchain technology.

Sci Rep

2023 Mar 9

Yang F, Deng J.

To accelerate the deep application of deep learning in text data processing, an English statistical translation system is established and applied to the question answering of humanoid robot. Firstly, the model of machine translation based on recursive neural network is implemented. A crawler system is established to collect English movie subtitle data. On this basis, an English subtitle translation system is designed. Then, combined with sentence embedding technology, the Particle Swarm Optimization (PSO) algorithm of meta-heuristic algorithm is adopted to locate the defects of translation software. A translation robot automatic question and answer interactive module is constructed. Additionally, the hybrid recommendation mechanism based on personalized learning is built using blockchain technology. Finally, the performance of translation model and software defect location model is evaluated. The results show that the Recurrent Neural Network (RNN) embedding algorithm has certain effect of word clustering. RNN embedded model has a strong ability to process short sentences. The strongest translated sentences are between 11 and 39 words long, while the weakest translated sentences are between 71 and 79 words long. Therefore, the model must strengthen the processing of long sentences, especially character-level input. The average sentence length is much longer than word-level input. The model based on PSO algorithm shows good accuracy in different data sets. This model averages better performance on Tomcat, standard widget toolkits, and Java development tool datasets than other comparison methods. The average reciprocal rank and average accuracy of the weight combination of PSO algorithm are very high. Moreover, this method is greatly affected by the dimension of the word embedding model, and the 300-dimension word embedding model has the best effect. To sum up, this study proposes a good statistical translation model for humanoid robot English translation, which lays the foundation for intelligent interaction between humanoid robots.

28. Quantum computing reduces systemic risk in financial networks.

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2023 Mar 9

Aboussalah AM, Chi C, Lee CG.

29. The normal impact stiffness of a debris-flow flexible barrier.

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2023 Mar 9

Huo M, Zhou JW, Zhao J

30. Initiation and modulation of Tau protein phase separation by the drug suramin.

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2023 Mar 9

Prince PR(#), Hochmair J(#), Brognaro H

31. A low-cost smartphone fluorescence microscope for research, life science education, and STEM outreach.

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2023 Mar 9

Schaefer MA, Nelson HN, Butrum JL

32. BSTS synthesis guided by CALPHAD approach for phase equilibria and process optimization.

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2023 Mar 9

Alnaser HF, Sparks TD.

33. Disease characteristics of idiopathic transverse myelitis with serum neuronal and astroglial damage biomarkers.

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2023 Mar 9

Kim KW, Lee EJ(#), Kim SY

34. Genome- and transcriptome-wide splicing associations with alcohol use disorder.

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2023 Mar 9

Huggett SB, Ikeda AS, Yuan Q

35. Association of myosteatosis with treatment response and survival in patients with hepatocellular carcinoma undergoing chemoembolization: a retrospective cohort study.

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2023 Mar 9

Bannangkoon K, Hongsakul K, Tubtawee T

Patients with hepatocellular carcinoma (HCC) have poor prognosis and have frequent treatment-related toxicities resulting in cancer-associated cachexia. This study aimed to determine the association of myosteatosis and sarcopenia on mortality in patients with HCC treated with transarterial chemoembolization (TACE). Six hundred and eleven patients diagnosed with HCC and underwent TACE at a tertiary care center between 2008 and 2019 were included. Body composition was assessed using axial CT slices at level L3 to calculate the skeletal muscle density for myosteatosis and skeletal muscle index for sarcopenia. The primary outcome was overall survival while the secondary outcome was TACE response. Patients with myosteatosis had a poorer TACE response than patients without myosteatosis (56.12% vs. 68.72%, adjusted odds ratio [OR] 0.49, 95% confidence interval [CI] 0.34-0.72). The rate of TACE response in patients with sarcopenia was not different from those without sarcopenia (60.91% vs. 65.22%, adjusted OR 0.79, 95% CI 0.55-1.13). Patients with myosteatosis had shorter overall survival than without myosteatosis (15.9 vs. 27.1 months, P < 0.001). In the multivariable Cox regression analysis, patients with myosteatosis or sarcopenia had higher risk of all-cause mortality than their counterparts (adjusted hazard ratio [HR] for myosteatosis versus no myosteatosis 1.66, 95% CI 1.37-2.01, adjusted HR for sarcopenia versus no sarcopenia 1.26, 95% CI 1.04-1.52). Patients with both myosteatosis and sarcopenia had the highest 7 year mortality rate at 94.45%, while patients with neither condition had the lowest mortality rate at 83.31%. The presence of myosteatosis was significantly associated with poor TACE response and reduced survival. Identifying patients with myosteatosis prior to TACE could allow for early interventions to preserve muscle quality and might improve prognosis in HCC patients.

36. Development of a patient-specific chest computed tomography imaging phantom with realistic lung lesions using silicone casting and three-dimensional printing.

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2023 Mar 9

Hong D, Moon S, Seo JB

37. High prevalence of parasitic chytrids infection of glacier algae in cryoconite holes in Alaska.

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2023 Mar 9

Kobayashi K, Takeuchi N, Kagami M.

38. Bioactivity of brassica seed meals and its compounds as ecofriendly larvicides against mosquitoes.

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2023 Mar 9

Flor-Weiler LB, Behle RW, Berhow MA

Strategic, sustainable, and ecofriendly alternatives to chemical pesticides are needed to effectively control mosquitoes and reduce the incidence of their vectored diseases. We evaluated several Brassicaceae (mustard family) seed meals as sources of plant derived isothiocyanates produced from the enzymatic hydrolysis of biologically inactive glucosinolates for the control of Aedes aegypti (L., 1762). Five defatted seed meals (Brassica juncea (L) Czern., 1859, Lepidium sativum L., 1753, Sinapis alba L., 1753, Thlaspi arvense L., 1753, and Thlaspi arvense-heat inactivated and three major chemical products of enzymatic degradation (allyl isothiocyanate, benzyl isothiocyanate and 4-hydroxybenzyl isothiocyanate) were assayed to determine toxicity (LC50) to Ae. aegypti larvae. All seed meals except the heat inactivated T. arvense were toxic to mosquito larvae. L. sativum seed meal was the most toxic treatment to larvae (LC50 = 0.04 g/120 mL dH2O) at the 24-h exposure. At the 72-h evaluation, the LC50 values for B. juncea, S. alba and T. arvense seed meals were 0.05, 0.08 and 0.1 g/120 mL dH2O, respectively. Synthetic benzyl isothiocyanate was more toxic to larvae 24-h post treatment (LC50 = 5.29 ppm) compared with allyl isothiocyanate (LC50 = 19.35 ppm) and 4-hydroxybenzyl isothiocyanate (LC50 = 55.41 ppm). These results were consistent with the higher performance of the benzyl isothiocyanate producing L. sativum seed meal. Isothiocyanates produced from seed meals were more effective than the pure chemical compounds, based on calculated LC50 rates. Using seed meal may provide an effective method of delivery for mosquito control. This is the first report evaluating the efficacy of five Brassicaceae seed meals and their major chemical constituent against mosquito larvae and demonstrates how natural compounds from Brassicaceae seed meals can serve as a promising ecofriendly larvicides to control mosquitoes.

39. In a secondary analysis from a randomised, double-blind placebo-controlled trial Dexmedetomidine blocks cholinergic dysregulation in delirium pathogenesis in patients with major surgery.

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2023 Mar 9

Jacob Y(#), Schneider B(#), Spies C

40. Algorithm of quantum engineering of large-amplitude high-fidelity Schrödinger cat states.

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2023 Mar 9

Podoshvedov MS, Podoshvedov SA, Kulik SP.

41. Cre-dependent ACR2-expressing reporter mouse strain for efficient long-lasting inhibition of neuronal activity.

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2023 Mar 9

Mukai Y(#), Li Y(#), Nakamura A

42. A CAD system for automatic dysplasia grading on H&E cervical whole-slide images.

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2023 Mar 9

Oliveira SP(#), Montezuma D(#), Moreira A(#)

43. Modulating heart rate oscillation affects plasma amyloid beta and tau levels in younger and older adults.

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2023 Mar 9

Min J, Rouanet J, Martini AC

44. Mucus increases cell iron uptake to impact the release of pro-inflammatory mediators after particle exposure.

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2023 Mar 9

Ghio AJ, Soukup JM, Dailey LA

45. Detecting type 2 diabetes mellitus cognitive impairment using whole-brain functional connectivity.

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2023 Mar 9

Wu J, Fang Y, Tan X

46. Combined adipose-derived mesenchymal stem cell and antibiotic therapy can effectively treat periprosthetic joint infection in rats.

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2023 Mar 9

Yamamuro Y, Kabata T, Nojima T

Periprosthetic joint infection (PJI) is characterized by biofilm infection, which is difficult to alleviate while preserving implant integrity. Furthermore, long-term antibiotic therapy may increase the prevalence of drug-resistant bacterial strains, necessitating a non-antibacterial approach. Adipose-derived stem cells (ADSCs) exert antibacterial effects; however, their efficacy in PJI remains unclear. This study investigates the efficacy of combined intravenous ADSCs and antibiotic therapy in comparison to antibiotic monotherapy in a methicillin-sensitive Staphylococcus aureus (MSSA)-infected PJI rat model. The rats were randomly assigned and equally divided into 3 groups: no-treatment group, antibiotic group, ADSCs with antibiotic group. The ADSCs with antibiotic group exhibited the fastest recovery from weight loss, with lower bacterial counts (p = 0.013 vs. no-treatment group; p = 0.024 vs. antibiotic group) and less bone density loss around the implants (p = 0.015 vs. no-treatment group; p = 0.025 vs. antibiotic group). The modified Rissing score was used to evaluate localized infection on postoperative day 14 and was the lowest in the ADSCs with antibiotic group; however, no significant difference was observed between the antibiotic group and ADSCs with antibiotic group (p < 0.001 vs. no-treatment group; p = 0.359 vs. antibiotic group). Histological analysis revealed a clear, thin, and continuous bony envelope, a homogeneous bone marrow, and a defined, normal interface in the ADSCs with antibiotic group. Moreover, the expression of cathelicidin expression was significantly higher (p = 0.002 vs. no-treatment group; p = 0.049 vs. antibiotic group), whereas that of tumor necrosis factor (TNF)-α and interleukin(IL)-6 was lower in the ADSCs with antibiotic group than in the no-treatment group (TNF-α, p = 0.010 vs. no-treatment group; IL-6, p = 0.010 vs. no-treatment group). Thus, the combined intravenous ADSCs and antibiotic therapy induced a stronger antibacterial effect than antibiotic monotherapy in a MSSA-infected PJI rat model. This strong antibacterial effect may be related to the increased cathelicidin expression and decreased inflammatory cytokine expression at the site of infection.

47. Numerical analysis of the ostiomeatal complex aeration using the CFD method.

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2023 Mar 9

Tretiakow D, Tesch K, Markiet K

48. Comparison of the association intensity of creatinine and cystatin C with hyperphosphatemia and hyperparathyroidism in patients with chronic kidney disease.

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2023 Mar 8

Min B, Yun SR, Yoon SH

49. Exposure to local, source-specific ambient air pollution during pregnancy and autism in children: a cohort study from southern Sweden.

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2023 Mar 8

Flanagan E, Malmqvist E, Rittner R

50. Creep behavior and long-term strength characteristics of pre-peak damaged sandstone under conventional triaxial compression.

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2023 Mar 8

Hou R, Cui Q, Wu H

51. Preparation of aluminium-hydroxide-modified diatomite and its fluoride adsorption mechanism.

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2023 Mar 8

Xiang B, Tang J, Feng X

52. Preparing pathological data to develop an artificial intelligence model in the nonclinical study.

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2023 Mar 8

Hwang JH, Lim M, Han G

53. R-LESS-RP versus C-LESS-RP: a single-institution retrospective comparative study.

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2023 Mar 8

Wei Y(#), Ji Q(#), Zhou X(#)

54. Development and validation of a method for analyzing the sialylated glycopeptides of recombinant erythropoietin in urine using LC-HRMS.

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2023 Mar 8

Seo Y, Park J, Lee HJ

55. Metabolic syndrome for the prognosis of postoperative complications after open pancreatic surgery in Chinese adult: a propensity score matching study.

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2023 Mar 8

Dai Y(#), Shi Y(#), Wang H

56. A bidirectional Mendelian randomized study of classical blood lipids and venous thrombosis.

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2023 Mar 8

Lin L, Luo P, Yang M

57. Ferromagnetic order controlled by the magnetic interface of LaNiO(3)/La(2/3)Ca(1/3)MnO(3) superlattices.

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2023 Mar 8

Soltan S, Macke S, Ilse SE

58. On taylor correlation functions in isotropic turbulent flows.

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2023 Mar 8

Chen W.

59. Seroprevalence and socioeconomic impact of the first SARS-CoV-2 infection wave in a small town in Navarre, Spain.

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2023 Mar 8

Ribes M, Montañà J, Vidal M

60. 3-Hydroxy-3-methylglutaryl coenzyme A reductase genes from Glycine max regulate plant growth and isoprenoid biosynthesis.

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2023 Mar 8

Wang S, Feng Y, Lou Y

61. Efficient noise mitigation technique for quantum computing.

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2023 Mar 8

Shaib A, Naim MH, Fouda ME

62. The extent of windfarm infrastructures on recognised European blanket bogs.

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2023 Mar 8

Chico G, Clewer T, Midgley NG

Peatland environments are the Earth's largest terrestrial carbon store and have the potential to act as carbon sinks. However, the development of windfarms on peatlands is affecting their morphology, hydrology, ground-level climate conditions, carbon functions and vegetation, and long-term consequences still need to be assessed. Blanket bogs are a rare type of ombrotrophic peatland that are typical of oceanic areas with high precipitation and low temperatures. Their distribution has been mapped across Europe, where they are mainly located on hill summits where wind energy potential is higher, making them attractive sites for windfarm developments. The promotion of renewable energy is currently a priority given the environmental and economic drive to increase low-carbon energy production. Establishing windfarms on peatland in pursuit of greener energy, therefore, risks compromising and undermining the green-energy transition. Despite this, the extent of windfarm infrastructures on blanket bogs have not yet been reported at the European scale. This research reports the extent of windfarm infrastructures on recognised blanket bogs, with a geographical focus on Europe, where blanket bogs have been mapped systematically. Under the EU Habitats Directive (92/43/EEC), there are 36 European regions NUTS level 2 with recognised blanket bogs. Of these, 12 have windfarm developments, including 644 wind turbines, 253.4 km of vehicular access tracks and an affected area of 207.6 ha, mainly in Ireland and Scotland where the extent of blanket bogs is also higher. However, despite Spain having under 0.2% of Europe's recognised blanket bogs area, this was the most affected country. In Scotland, a comparison of the recognised blanket bogs under the Habitats Directive (92/43/EEC) with blanket bogs recorded in national inventories indicates that the extent of windfarm developments was higher, with 1,063 wind turbines and 634.5 km of vehicular access tracks. Our results highlight the extent of windfarm developments on blanket bog habitat, both in areas where peatlands are broadly distributed across the landscape, and also in areas where this recognised habitat is particularly rare. There is a pressing need to assess the long-term impacts of windfarms on peatlands to ensure that efforts to meet energy targets result only in carbon sequestration, and do not jeopardise ecosystem services. Blanket bogs represent a particularly vulnerable habitat, the study of which should be prioritised updating national and international inventories to protect and restore this habitat.

63. Inhibitory effect of 405 nm laser light on bacterial biofilm in urethral stent.

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2023 Mar 8

Maknuna L, Tran VN, Lee BI

64. Process optimization and kinetic study of biodegradation of dimethyl phthalate by KS2, a novel strain of Micrococcus sp.

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2023 Mar 8

Patil SS, Jena HM.

65. Smoking and passive smoking increases mortality through mediation effect of cadmium exposure in the United States.

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2023 Mar 8

Kim J(#), Song H(#), Lee J

66. Seasonal trends in COVID-19 cases, hospitalizations, and mortality in the United States and Europe.

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2023 Mar 8

Wiemken TL, Khan F, Puzniak L

67. Modeling and comparing minimum miscibility pressure using multiple mixing cells for injection of enriched gases with Naphta, LPG, and NGL.

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2023 Mar 8

Rashidi MA, Khademahmadi MR, Kazemzadeh Y

68. Cognitive and plastic recurrent neural network clock model for the judgment of time and its variations.

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2023 Mar 8

Hallez Q, Mermillod M, Droit-Volet S.

69. Proximal versus distal bone transport for the management of large segmental tibial defect: a clinical case series.

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2023 Mar 8

Lu Y, Wang Q, Ren C

70. Geosmin suppresses defensive behaviour and elicits unusual neural responses in honey bees.

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2023 Mar 8

Scarano F, Deivarajan Suresh M, Tiraboschi E

71. A hybrid classical-quantum approach to speed-up Q-learning.

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2023 Mar 8

Sannia A, Giordano A, Gullo NL

72. Seagrass deformation affects fluid instability and tracer exchange in canopy flow.

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2023 Mar 8

Vieira GS, Allshouse MR, Mahadevan A.

73. The Geriatric Nutritional Risk Index predicts sarcopenia in patients with cirrhosis.

Sci Rep

2023 Mar 8

Saeki C, Kinoshita A, Kanai T

74. The quality of vital signs measurements and value preferences in electronic medical records varies by hospital, specialty, and patient demographics.

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2023 Mar 8

Jackson N, Woods J, Watkinson P

75. Assessment of long-term large deformation in deep roadways due to roof fracturing impact loading.

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2023 Mar 8

Huang W, Golsanami N, Zhang C

76. Horses cross-modally recognize women and men.

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2023 Mar 8

Gouyet C, Ringhofer M, Yamamoto S

77. A screen for MeCP2-TBL1 interaction inhibitors using a luminescence-based assay.

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2023 Mar 8

Alexander-Howden B(#), Zhang L(#), van der Sloot AM

78. Functional interaction between Vangl2 and N-cadherin regulates planar cell polarization of the developing neural tube and cochlear sensory epithelium.

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2023 Mar 8

Nagaoka T, Katsuno T, Fujimura K

79. Intelligent computing with Levenberg-Marquardt artificial neural network for Carbon nanotubes-water between stretchable rotating disks.

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2023 Mar 8

Ali F, Awais M, Ali A

80. A comprehensive analysis of PANoptosome to prognosis and immunotherapy response in pan-cancer.

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2023 Mar 8

Zhuang L, Sun Q, Huang S

81. Association of smoking and osteoarthritis in US (NHANES 1999-2018).

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2023 Mar 8

Zhu S, Ji L, He Z

82. Left atrial size predicts outcome in severe but asymptomatic mitral regurgitation.

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2023 Mar 8

Zilberszac R, Gleiss A, Massetti M

83. Effect of bedding dip angle and dynamic load on spatial variation of microscopic failure stress of shale.

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2023 Mar 8

Wang M, Shao X, Pan X.

84. Detached, wetted strawberries take up substantial water in the calyx region.

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2023 Mar 8

Hurtado G, Knoche M.

85. Waste cooking oil processing over cobalt aluminate nanoparticles for liquid biofuel hydrocarbons production.

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2023 Mar 8

Ibrahim MA, El-Araby R, Abdelkader E

86. The median eyes of trilobites.

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2023 Mar 8

Schoenemann B, Clarkson ENK.

87. Insight into pressure effect on optoelectronic, mechanical, and lattice vibrational properties of nanostructured Ga(x)In(1 - x)P(y)Sb(z)As(1 - y - z) for the solar cells system.

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2023 Mar 8

Elkenany EB, Alfrnwani OA, Sallah M.

88. Pre- and peri-natal hurricane exposure alters DNA methylation patterns in children.

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2023 Mar 8

Kello E(#), Vieira AR(#), Rivas-Tumanyan S

89. Climate, landscape, and life history jointly predict multidecadal community mosquito phenology.

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2023 Mar 8

Campbell LP, Sallam MF, Bauer AM

90. Revealing the hidden signature of fault slip history in the morphology of degrading scarps.

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2023 Mar 8

Holtmann R(#), Cattin R(#), Simoes M(#)

91. Vole outbreaks may induce a tularemia disease pit that prevents Iberian hare population recovery in NW Spain.

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2023 Mar 8

Rouco C, Luque-Larena JJ, Vidal D

92. The prognostic role of C-reactive protein to albumin ratio and anti-MDA5 antibody-positive in idiopathic inflammatory myopathy: a retrospective study.

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2023 Mar 8

Zhou P, Shen Q, Zhou S

93. A significant, functional and replicable risk KTN1 variant block for schizophrenia.

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2023 Mar 8

Mao Q(#), Lin X(#), Yin Q(#)

Cortical and subcortical structural alteration has been extensively reported in schizophrenia, including the unusual expansion of gray matter volumes (GMVs) of basal ganglia (BG), especially putamen. Previous genome-wide association studies pinpointed kinectin 1 gene (KTN1) as the most significant gene regulating the GMV of putamen. In this study, the role of KTN1 variants in risk and pathogenesis of schizophrenia was explored. A dense set of SNPs (n = 849) covering entire KTN1 was analyzed in three independent European- or African-American samples (n = 6704) and one mixed European and Asian Psychiatric Genomics Consortium sample (n = 56,418 cases vs. 78,818 controls), to identify replicable SNP-schizophrenia associations. The regulatory effects of schizophrenia-associated variants on the KTN1 mRNA expression in 16 cortical or subcortical regions in two European cohorts (n = 138 and 210, respectively), the total intracranial volume (ICV) in 46 European cohorts (n = 18,713), the GMVs of seven subcortical structures in 50 European cohorts (n = 38,258), and the surface areas (SA) and thickness (TH) of whole cortex and 34 cortical regions in 50 European cohorts (n = 33,992) and eight non-European cohorts (n = 2944) were carefully explored. We found that across entire KTN1, only 26 SNPs within the same block (r2 > 0.85) were associated with schizophrenia across ≥ 2 independent samples (7.5 × 10-5 ≤ p ≤ 0.048). The schizophrenia-risk alleles, which increased significantly risk for schizophrenia in Europeans (q < 0.05), were all minor alleles (f < 0.5), consistently increased (1) the KTN1 mRNA expression in 12 brain regions significantly (5.9 × 10-12 ≤ p ≤ 0.050; q < 0.05), (2) the ICV significantly (6.1 × 10-4 ≤ p ≤ 0.008; q < 0.05), (3) the SA of whole (9.6 × 10-3 ≤ p ≤ 0.047) and two regional cortices potentially (2.5 × 10-3 ≤ p ≤ 0.042; q > 0.05), and (4) the TH of eight regional cortices potentially (0.006 ≤ p ≤ 0.050; q > 0.05), and consistently decreased (1) the BG GMVs significantly (1.8 × 10-19 ≤ p ≤ 0.050; q < 0.05), especially putamen GMV (1.8 × 10-19 ≤ p ≤ 1.0 × 10-4; q < 0.05, (2) the SA of four regional cortices potentially (0.010 ≤ p ≤ 0.048), and (3) the TH of four regional cortices potentially (0.015 ≤ p ≤ 0.049) in Europeans. We concluded that we identified a significant, functional, and robust risk variant block covering entire KTN1 that might play a critical role in the risk and pathogenesis of schizophrenia.

94. Characteristics of the Northern Hemisphere cold regions changes from 1901 to 2019.

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2023 Mar 8

Huang Y, Zhang L, Li Y

The accurate delineation of the spatial extent of cold regions provides the basis for the study of global environmental change. However, attention has been lacking on the temperature-sensitive spatial changes in the cold regions of the Earth in the context of climate warming. In this study, the mean temperature in the coldest month lower than - 3 °C, no more than 5 months over 10 °C, and an annual mean temperature no higher than 5 °C were selected to define cold regions. Based on the Climate Research Unit land surface air temperature (CRUTEM) of monthly mean surface climate elements, the spatiotemporal distribution and variation characteristics of the Northern Hemisphere (NH) continental cold regions from 1901 to 2019 are analyzed in this study, by adopting time trend and correlation analyses. The results show: (1) In the past 119 years, the cold regions of the NH covered on average about 4.074 × 107 km2, accounting for 37.82% of the total land area of the NH. The cold regions can be divided into the Mid-to-High latitude cold regions and the Qinghai-Tibetan Plateau cold regions, with spatial extents of 3.755 × 107 km2 and 3.127 × 106 km2, respectively. The Mid-to-High latitude cold regions in the NH are mainly distributed in northern North America, most of Iceland, the Alps, northern Eurasia, and the Great Caucasus with a mean southern boundary of 49.48° N. Except for the southwest, the entire region of the Qinghai-Tibetan Plateau, northern Pakistan, and most of Kyrgyzstan are cold regions. (2) In the past 119 years, the rates of change in the spatial extent of the cold regions in the NH, the Mid-to-High latitude, and the Qinghai-Tibetan Plateau were - 0.030 × 107 km2/10 a, - 0.028 × 107 km2/10 a, and - 0.013 × 106 km2/10 a, respectively, showing an extremely significant decreasing trend. In the past 119 years, the mean southern boundary of the Mid-to-High latitude cold regions has been retreating northward at all longitudes. For instance, the mean southern boundary of the Eurasian cold regions moved 1.82° to the north and that of North America moved 0.98° to the north. The main contribution of the study lies in the accurate definition of the cold regions and documentation of the spatial variation of the cold regions in the NH, revealing the response trends of the cold regions to climate warming, and deepening the study of global change from a new perspective.

95. A case study of impacts of an extreme weather system on the Mediterranean Sea circulation features: Medicane Apollo (2021).

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2023 Mar 8

Menna M, Martellucci R, Reale M

96. Persistent impacts of smoking on resting-state EEG in male chronic smokers and past-smokers with 20 years of abstinence.

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2023 Mar 8

Lee H(#), Jeon Y(#), Yoo C

97. Quantitative electroencephalographic biomarker of pharmacological treatment response in patients with anxiety disorder: a retrospective study.

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2023 Mar 7

Byeon J, Moon JY, Je SR

98. Input node placement restricting the longest control chain in controllability of complex networks.

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2023 Mar 7

Alizadeh S, Pósfai M, Ghasemi A.

99. The inhibitory effect and mechanism of Resina Draconis on the proliferation of MCF-7 breast cancer cells: a network pharmacology-based analysis.

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2023 Mar 7

Lv Y(#), Mou Y(#), Su J

Resina Draconis (RD) is known as the "holy medicine for promoting blood circulation" and possesses antitumor properties against various types of cancer, including breast cancer (BC); however, the underlying mechanism is not well understood. To explore the potential mechanism of RD against BC using network pharmacology and experimental validation, data on bioactive compounds, potential targets of RD, and related genes of BC were obtained from multiple public databases. Gene Ontology (GO) and KEGG pathway analyses were performed via the DAVID database. Protein interactions were downloaded from the STRING database. The mRNA and protein expression levels and survival analysis of the hub targets were analyzed using the UALCAN, HPA, Kaplan‒Meier mapper, and cBioPortal databases. Subsequently, molecular docking was used to verify the selected key ingredients and hub targets. Finally, the predicted results of network pharmacology methods were verified by cell experiments. In total, 160 active ingredients were obtained, and 148 RD target genes for the treatment of BC were identified. KEGG pathway analysis indicated that RD exerted its therapeutic effects on BC by regulating multiple pathways. Of these, the PI3K-AKT pathway was indicated to play an important role. In addition, RD treatment of BC seemed to involve the regulation of hub targets that were identified based on PPI interaction network analysis. Validation in different databases showed that AKT1, ESR1, HSP90AA1, CASP3, SRC and MDM2 may be involved in the carcinogenesis and progression of BC and that ESR1, IGF1 and HSP90AA1 were correlated with worse overall survival (OS) in BC patients. Molecular docking results showed that 103 active compounds have good binding activity with the hub targets, among which flavonoid compounds were the most important active components. Therefore, the sanguis draconis flavones (SDF) were selected for subsequent cell experiments. The experimental results showed that SDF significantly inhibited the cell cycle and cell proliferation of MCF-7 cells through the PI3K/AKT pathway and induced MCF-7 cell apoptosis. This study has preliminarily reported on the active ingredients, potential targets, and molecular mechanism of RD against BC, and RD was shown to exert its therapeutic effects on BC by regulating the PI3K/AKT pathway and related gene targets. Importantly, our work could provide a theoretical basis for further study of the complex anti-BC mechanism of RD.

100. Prognostic impact of lymphovascular and perineural invasion in squamous cell carcinoma of the tongue.

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2023 Mar 7

Huang Q, Huang Y, Chen C

101. Extensive MHC class IIβ diversity across multiple loci in the small-spotted catshark (Scyliorhinus canicula).

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2023 Mar 7

Gaigher A, Rota A, Neves F

102. Mechanisms of regulation of motility of the gastrointestinal tract and the hepatobiliary system under the chronic action of nanocolloids.

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2023 Mar 7

Tsymbalyuk OV, Davydovska TL, Naumenko AM

103. Differentially expressed discriminative genes and significant meta-hub genes based key genes identification for hepatocellular carcinoma using statistical machine learning.

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2023 Mar 7

Hasan MAM, Maniruzzaman M, Shin J.

Hepatocellular carcinoma (HCC) is the most common lethal malignancy of the liver worldwide. Thus, it is important to dig the key genes for uncovering the molecular mechanisms and to improve diagnostic and therapeutic options for HCC. This study aimed to encompass a set of statistical and machine learning computational approaches for identifying the key candidate genes for HCC. Three microarray datasets were used in this work, which were downloaded from the Gene Expression Omnibus Database. At first, normalization and differentially expressed genes (DEGs) identification were performed using limma for each dataset. Then, support vector machine (SVM) was implemented to determine the differentially expressed discriminative genes (DEDGs) from DEGs of each dataset and select overlapping DEDGs genes among identified three sets of DEDGs. Enrichment analysis was performed on common DEDGs using DAVID. A protein-protein interaction (PPI) network was constructed using STRING and the central hub genes were identified depending on the degree, maximum neighborhood component (MNC), maximal clique centrality (MCC), centralities of closeness, and betweenness criteria using CytoHubba. Simultaneously, significant modules were selected using MCODE scores and identified their associated genes from the PPI networks. Moreover, metadata were created by listing all hub genes from previous studies and identified significant meta-hub genes whose occurrence frequency was greater than 3 among previous studies. Finally, six key candidate genes (TOP2A, CDC20, ASPM, PRC1, NUSAP1, and UBE2C) were determined by intersecting shared genes among central hub genes, hub module genes, and significant meta-hub genes. Two independent test datasets (GSE76427 and TCGA-LIHC) were utilized to validate these key candidate genes using the area under the curve. Moreover, the prognostic potential of these six key candidate genes was also evaluated on the TCGA-LIHC cohort using survival analysis.

104. Neurological outcomes after surgery and postoperative rehabilitation for cervical radiculopathy due to disc disease: a 2-year-follow-up of a randomized clinical trial.

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2023 Mar 7

Peolsson A, Löfgren H, Dedering Å

105. Automatic comprehensive aspects reports in clinical acute stroke MRIs.

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2023 Mar 7

Liu CF, Li J, Kim G

106. Correction of haemorrhagic shock-associated coagulopathy and impaired haemostasis by plasma, prothrombin complex concentrates or an activated protein C-targeted DNA aptamer in mice.

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2023 Mar 7

Eltringham-Smith LJ, Meixner SC, Pryzdial ELG

107. Osteoclastogenesis of human peripheral blood, bone marrow, and cord blood monocytes.

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2023 Mar 7

Vuoti E, Lehenkari P, Tuukkanen J

108. Emotion recognition based on group phase locking value using convolutional neural network.

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2023 Mar 7

Cui G, Li X, Touyama H.

109. A new hybrid algorithm for three-stage gene selection based on whale optimization.

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2023 Mar 7

Liu J(#), Qu C(#), Zhang L(#)

110. Controllable large positive and negative Goos-Hänchen shifts with a double-Lambda atomic system.

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2023 Mar 7

Othman A, Asiri S, Al-Amri M.

111. Subsistence of early anatomically modern humans in Europe as evidenced in the Protoaurignacian occupations of Fumane Cave, Italy.

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2023 Mar 7

Marín-Arroyo AB, Terlato G, Vidal-Cordasco M

112. Smoking-induced subgingival dysbiosis precedes clinical signs of periodontal disease.

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2023 Mar 7

Tamashiro R(#), Strange L(#), Schnackenberg K

113. Virtual monoenergetic imaging predicting Ki-67 expression in lung cancer.

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2023 Mar 7

Dou P, Zhao H, Zhong D

114. Single-blind validation of space-based point-source detection and quantification of onshore methane emissions.

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2023 Mar 7

Sherwin ED, Rutherford JS, Chen Y

115. ATP synthase interactome analysis identifies a new subunit l as a modulator of permeability transition pore in yeast.

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2023 Mar 7

Panja C, Wiesyk A, Niedźwiecka K

116. Presepsin as a diagnostic and prognostic biomarker of severe bacterial infections and COVID-19.

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2023 Mar 7

Kyriazopoulou E, Leventogiannis K, Tavoulareas G

117. Buckling and shape control of prestressable trusses using optimum number of actuators.

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2023 Mar 7

Manguri A, Saeed N, Szczepanski M

118. The dynamics of novel corona virus disease via stochastic epidemiological model with vaccination.

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2023 Mar 7

Ullah R(#), Al Mdallal Q(#), Khan T(#)

119. Ginkgo biloba extracts improve choroidal circulation leading to suppression of myopia in mice.

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2023 Mar 7

Hou J(#), Mori K(#), Ikeda SI

120. Near-field sensor array with 65-GHz CMOS oscillators can rapidly and comprehensively evaluate drug susceptibility of Mycobacterium.

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2023 Mar 7

Kikuchi S(#), Yamashige Y, Hosoki R

121. Investigating mechanisms of laser pulse-induced reflectivity modulations in photoacoustic remote sensing with a 10 million frames-per-second camera.

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2023 Mar 7

Haven NJM, Martell MT, Li H

122. Hypoxia-induced transcriptional differences in African and Asian versus European diabetic cybrids.

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2023 Mar 7

Dolinko AH, Chwa M, Schneider K

123. Roles of PI3Kγ and PI3Kδ in mantle cell lymphoma proliferation and migration contributing to efficacy of the PI3Kγ/δ inhibitor duvelisib.

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2023 Mar 7

Till KJ, Abdullah M(#), Alnassfan T(#)

124. Statistical inference with joint progressive censoring for two populations using power Rayleigh lifetime distribution.

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2023 Mar 7

Tolba AH, Abushal TA, Ramadan DA.

125. Release of sterile Aedes aegypti mosquitoes: chilling effect on mass-reared males survival and escape ability and on irradiated males sexual competitiveness.

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2023 Mar 7

Sánchez-Aldana-Sánchez GA, Liedo P, Bond JG

126. Key therapeutic targets implicated at the early stage of hepatocellular carcinoma identified through machine-learning approaches.

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2023 Mar 7

Hosseiniyan Khatibi SM(#), Najjarian F(#), Homaei Rad H

127. The ratio of TAPSE to PASP predicts prognosis in lung transplant candidates with pulmonary arterial hypertension.

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2023 Mar 7

Ishii S, Minatsuki S, Hatano M

128. Understanding who talks about what: comparison between the information treatment in traditional media and online discussions.

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2023 Mar 7

Schawe H, Beiró MG, Alvarez-Hamelin JI

129. Stent expansion evaluated by optical coherence tomography and subsequent outcomes.

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2023 Mar 7

Lee B(#), Baraki TG(#), Kim BG

130. A high throughput method for egg size measurement in Drosophila.

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2023 Mar 7

Barghi N, Ramirez-Lanzas C.

131. Umbilical cord-derived mesenchymal stromal cell therapy to prevent the development of neurodevelopmental disorders related to low birth weight.

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2023 Mar 7

Tsuji M, Mukai T, Sato Y

132. Novel methods for reliability study of multi-dimensional non-linear dynamic systems.

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2023 Mar 7

Gaidai O, Xu J, Yan P

This research presents two unique techniques for engineering system reliability analysis of multi-dimensional non-linear dynamic structures. First, the structural reliability technique works best for multi-dimensional structural responses that have been either numerically simulated or measured over a long enough length to produce an ergodic time series. Second, a novel extreme value prediction method that can be used in various engineering applications is proposed. In contrast to those currently used in engineering reliability methodologies, the novel method is easy to use, and even a limited amount of data can still be used to obtain robust system failure estimates. As demonstrated in this work, proposed methods also provide accurate confidence bands for system failure levels in the case of real-life measured structural response. Additionally, traditional reliability approaches that deal with time series do not have the benefit of being able to handle a system's high dimensionality and cross-correlation across several dimensions readily. Container ship that experiences significant deck panel pressures and high roll angles when travelling in bad weather was selected as the example for this study. The main concern for ship transportation is the potential loss of cargo owing to violent movements. Simulating such a situation is difficult since waves and ship motions are non-stationary and complicatedly non-linear. Extreme movements greatly enhance the role of nonlinearities, activating effects of second and higher order. Furthermore, laboratory testing may also be called into doubt due to the scale and the choice of the sea state. Therefore, data collected from actual ships during difficult weather journeys offer a unique perspective on the statistics of ship movements. This work aims to benchmark state-of-the-art methods, making it possible to extract necessary information about the extreme response from available on-board measured time histories. Both suggested methods can be used in combination, making them attractive and ready to use for engineers. Methods proposed in this paper open up possibilities to predict simply yet efficiently system failure probability for non-linear multi-dimensional dynamic structure.

133. Author Correction: Comparability of automated drusen volume measurements in age-related macular degeneration: a MACUSTAR study report.

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2023 Mar 7

Garzone D, Terheyden JH, Morelle O

134. MFCSC: Novel method to calculate mismatch between functional and structural brain connectomes, and its application for detecting hemispheric functional specialisations.

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2023 Mar 7

Civier O, Sourty M, Calamante F.

135. Quantum asymmetric key crypto scheme using Grover iteration.

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2023 Mar 7

Yoon CS, Hong CH, Kang MS

136. EHR foundation models improve robustness in the presence of temporal distribution shift.

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2023 Mar 7

Guo LL, Steinberg E, Fleming SL

Temporal distribution shift negatively impacts the performance of clinical prediction models over time. Pretraining foundation models using self-supervised learning on electronic health records (EHR) may be effective in acquiring informative global patterns that can improve the robustness of task-specific models. The objective was to evaluate the utility of EHR foundation models in improving the in-distribution (ID) and out-of-distribution (OOD) performance of clinical prediction models. Transformer- and gated recurrent unit-based foundation models were pretrained on EHR of up to 1.8 M patients (382 M coded events) collected within pre-determined year groups (e.g., 2009-2012) and were subsequently used to construct patient representations for patients admitted to inpatient units. These representations were used to train logistic regression models to predict hospital mortality, long length of stay, 30-day readmission, and ICU admission. We compared our EHR foundation models with baseline logistic regression models learned on count-based representations (count-LR) in ID and OOD year groups. Performance was measured using area-under-the-receiver-operating-characteristic curve (AUROC), area-under-the-precision-recall curve, and absolute calibration error. Both transformer and recurrent-based foundation models generally showed better ID and OOD discrimination relative to count-LR and often exhibited less decay in tasks where there is observable degradation of discrimination performance (average AUROC decay of 3% for transformer-based foundation model vs. 7% for count-LR after 5-9 years). In addition, the performance and robustness of transformer-based foundation models continued to improve as pretraining set size increased. These results suggest that pretraining EHR foundation models at scale is a useful approach for developing clinical prediction models that perform well in the presence of temporal distribution shift.

137. A novel DNA methylation signature to improve survival prediction of progression-free survival for testicular germ cell tumors.

Sci Rep

2023 Mar 7

Gao F(#), Xu Q(#), Jiang Y

This study aimed to develop a nomogram for predicting the progression-free survival (PFS) of testicular germ cell tumors (TGCT) patients based on DNA methylation signature and clinicopathological characteristics. The DNA methylation profiles, transcriptome data, and clinical information of TGCT patients were obtained from the Cancer Genome Atlas (TCGA) database. Univariate Cox, lasso Cox, and stepwise multivariate Cox regression were applied to identify a prognostic CpG sites-derived risk signature. Differential expression analysis, functional enrichment analysis, immunoinfiltration analysis, chemotherapy sensitivity analysis, and clinical feature correlation analysis were performed to elucidate the differences among risk groups. A prognostic nomogram integrating CpG sites-derived risk signature and clinicopathological features was further established and evaluated likewise. A risk score model based on 7 CpG sites was developed and found to exhibit significant differences among different survival, staging, radiotherapy, and chemotherapy subgroups. There were 1452 differentially expressed genes between the high- and low-risk groups, with 666 being higher expressed and 786 being lower expressed. Genes highly expressed were significantly enriched in immune-related biological processes and related to T-cell differentiation pathways; meanwhile, down-regulated genes were significantly enriched in extracellular matrix tissue organization-related biological processes and involved in multiple signaling pathways such as PI3K-AKT. As compared with the low-risk group, patients in the high-risk group had decreased lymphocyte infiltration (including T-cell and B-cell) and increased macrophage infiltration (M2 macrophages). They also showed decreased sensitivity to etoposide and bleomycin chemotherapy. Three clusters were obtained by consensus clustering analysis based on the 7 CpG sites and showed distinct prognostic features, and the risk scores in each cluster were significantly different. Multivariate Cox regression analysis found that the risk scores, age, chemotherapy, and staging were independent prognostic factors of PFS of TGCT, and the results were used to formulate a nomogram model that was validated to have a C-index of 0.812. Decision curve analysis showed that the nomogram model was superior to other strategies in the prediction of PFS of TGCT. In this study, we successfully established CpG sites-derived risk signature, which might serve as a useful tool in the prediction of PFS, immunoinfiltration, and chemotherapy sensitivity for TGCT patients.

138. Seasonal variation in morphotype composition of pelagic Sargassum influx events is linked to oceanic origin.

Sci Rep

2023 Mar 7

Alleyne KST, Johnson D, Neat F

The recent proliferation of pelagic Sargassum spp. in the Tropical Atlantic causes major ecological and socioeconomic impacts to the wider Caribbean when it washes ashore, with regional fisheries and tourism industries particularly affected. The Caribbean influxes have been tracked to a new bloom region known as the North Equatorial Recirculation Region (NERR) encompassing the area between the South Equatorial Current and the North Equatorial Counter Current and extending from Africa to South America. The vast biomass of Sargassum presents serious problems when it washes ashore but also represents significant commercial opportunities, especially with biofuel and fertilizer. The floating Sargassum mats are themselves diverse ecosystems that vary both in their biodiversity and biochemical attributes. Two major species (Sargassum fluitans and S. natans) have been identified as well as several distinguishable morphotypes of each. Oceanic mixing tends to blend the morphotypes together making it difficult to determine if there are regions of the NERR that favour bloom and growth of the distinct types. In this study, we quantify the species and morphotype composition of Sargassum strandings in Barbados and test if this is related to separate oceanic origins and routes travelled using a backtracking algorithm based on ocean drifter data. We found significant seasonal variation in the relative abundance of three morphotypes and this could be traced to two distinct easterly sub-origins and/or transport pathways; one area around 15° N that travels directly E-W across the Atlantic, and another area generally south of 10° N that takes a more meandering route coming close the coast of South America. These findings contribute towards our understanding of why the Tropical Atlantic bloom is presently occurring as well as towards addressing valorisation constraints surrounding variation in the supply of the three commonly occurring morphotypes.

139. Intelligent modeling of hydrogen sulfide solubility in various types of single and multicomponent solvents.

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2023 Mar 7

Moradkhani MA, Hosseini SH, Ranjbar K

140. Noble metal catalyst detection in rocks using machine-learning: The future to low-cost, green energy materials?

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2023 Mar 7

Ifandi E, Lai DTC, Kalaitzidis S

141. Extensive 3D mapping of dislocation structures in bulk aluminum.

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2023 Mar 7

Yildirim C(#), Poulsen HF, Winther G

142. Association of general and central obesity, and their changes with risk of knee osteoarthritis: a nationwide population-based cohort study.

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2023 Mar 7

Park D, Park YM, Ko SH

143. Permittivity boosting by induced strain from local doping in titanates from first principles.

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2023 Mar 7

Kutana A, Shimano Y, Asahi R.

144. Serum metabolomic profile of hair dye use.

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2023 Mar 7

Lim JE, Huang J, Weinstein SJ

145. Ligamentum flavum analysis in patients with lumbar discus hernia and lumbar spinal stenosis.

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2023 Mar 7

Aleksić V, Todorović J, Miladinović N

146. First paleoproteome study of fossil fish otoliths and the pristine preservation of the biomineral crystal host.

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2023 Mar 7

Stolarski J, Drake J, Coronado I

147. A transparent artificial intelligence framework to assess lung disease in pulmonary hypertension.

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2023 Mar 7

Mamalakis M, Dwivedi K, Sharkey M

148. Drug_SNSMiner: standard pharmacovigilance pipeline for detection of adverse drug reaction using SNS data.

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2023 Mar 7

Lee S(#), Woo H(#), Lee CC

149. Interaural time difference sensitivity under binaural cochlear implant stimulation persists at high pulse rates up to 900 pps.

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2023 Mar 7

Buck AN(#), Buchholz S, Schnupp JW

Spatial hearing remains one of the major challenges for bilateral cochlear implant (biCI) users, and early deaf patients in particular are often completely insensitive to interaural time differences (ITDs) delivered through biCIs. One popular hypothesis is that this may be due to a lack of early binaural experience. However, we have recently shown that neonatally deafened rats fitted with biCIs in adulthood quickly learn to discriminate ITDs as well as their normal hearing litter mates, and perform an order of magnitude better than human biCI users. Our unique behaving biCI rat model allows us to investigate other possible limiting factors of prosthetic binaural hearing, such as the effect of stimulus pulse rate and envelope shape. Previous work has indicated that ITD sensitivity may decline substantially at the high pulse rates often used in clinical practice. We therefore measured behavioral ITD thresholds in neonatally deafened, adult implanted biCI rats to pulse trains of 50, 300, 900 and 1800 pulses per second (pps), with either rectangular or Hanning window envelopes. Our rats exhibited very high sensitivity to ITDs at pulse rates up to 900 pps for both envelope shapes, similar to those in common clinical use. However, ITD sensitivity declined to near zero at 1800 pps, for both Hanning and rectangular windowed pulse trains. Current clinical cochlear implant (CI) processors are often set to pulse rates ≥ 900 pps, but ITD sensitivity in human CI listeners has been reported to decline sharply above ~ 300 pps. Our results suggest that the relatively poor ITD sensitivity seen at > 300 pps in human CI users may not reflect the hard upper limit of biCI ITD performance in the mammalian auditory pathway. Perhaps with training or better CI strategies good binaural hearing may be achievable at pulse rates high enough to allow good sampling of speech envelopes while delivering usable ITDs.

150. The efficiency of quantum teleportation with three-qubit entangled state in a noisy environment.

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2023 Mar 7

Zhang CY, Zheng ZJ, Fan ZB

151. Enhanced performance of flexible quantum dot light-emitting diodes using a low-temperature processed PTAA hole transport layer.

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2023 Mar 7

Ha HJ, Kim MG, Ma JH

152. EHD stability of a cylindrical boundary separating double Reiner-Rivlin fluids.

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2023 Mar 7

Moatimid GM, Mostapha DR.

153. Generation of a recombinant temperature-sensitive influenza D virus.

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2023 Mar 7

Ishida H, Murakami S, Kamiki H

154. Histone H3-wild type diffuse midline gliomas with H3K27me3 loss are a distinct entity with exclusive EGFR or ACVR1 mutation and differential methylation of homeobox genes.

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2023 Mar 7

Ajuyah P(#), Mayoh C(#), Lau LMS

155. Real-world data on the incidence and risk of Guillain-Barré syndrome following SARS-CoV-2 vaccination: a prospective surveillance study.

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2023 Mar 7

Ha J(#), Park S(#), Kang H

156. Benthic jellyfish act as suction pumps to facilitate release of interstitial porewater.

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2023 Mar 7

Durieux DM, Scrogham GD, Fender C

157. Experimental analysis on cyanide removal of gold tailings under medium-temperature roasting.

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2023 Mar 7

Hai L, Fang X, Zhao X

158. On electromagnetic head digitization in MEG and EEG.

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2023 Mar 7

Jaiswal A, Nenonen J, Parkkonen L.

In MEG and EEG studies, the accuracy of the head digitization impacts the co-registration between functional and structural data. The co-registration is one of the major factors that affect the spatial accuracy in MEG/EEG source imaging. Precisely digitized head-surface (scalp) points do not only improve the co-registration but can also deform a template MRI. Such an individualized-template MRI can be used for conductivity modeling in MEG/EEG source imaging if the individual's structural MRI is unavailable. Electromagnetic tracking (EMT) systems (particularly Fastrak, Polhemus Inc., Colchester, VT, USA) have been the most common solution for digitization in MEG and EEG. However, they may occasionally suffer from ambient electromagnetic interference which makes it challenging to achieve (sub-)millimeter digitization accuracy. The current study-(i) evaluated the performance of the Fastrak EMT system under different conditions in MEG/EEG digitization, and (ii) explores the usability of two alternative EMT systems (Aurora, NDI, Waterloo, ON, Canada; Fastrak with a short-range transmitter) for digitization. Tracking fluctuation, digitization accuracy, and robustness of the systems were evaluated in several test cases using test frames and human head models. The performance of the two alternative systems was compared against the Fastrak system. The results showed that the Fastrak system is accurate and robust for MEG/EEG digitization if the recommended operating conditions are met. The Fastrak with the short-range transmitter shows comparatively higher digitization error if digitization is not carried out very close to the transmitter. The study also evinces that the Aurora system can be used for MEG/EEG digitization within a constrained range; however, some modifications would be required to make the system a practical and easy-to-use digitizer. Its real-time error estimation feature can potentially improve digitization accuracy.

159. Verteporfin-induced proteotoxicity impairs cell homeostasis and survival in neuroblastoma subtypes independent of YAP/TAZ expression.

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2023 Mar 7

Condurat AL, Aminzadeh-Gohari S, Malnar M

160. A buprenorphine depot formulation provides effective sustained post-surgical analgesia for 72 h in mouse femoral fracture models.

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2023 Mar 7

Wolter A, Bucher CH, Kurmies S

161. Cannabidiol improves muscular lipid profile by affecting the expression of fatty acid transporters and inhibiting de novo lipogenesis.

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2023 Mar 6

Bielawiec P, Dziemitko S, Konstantynowicz-Nowicka K

162. Integrated multi-omics analysis of Alzheimer's disease shows molecular signatures associated with disease progression and potential therapeutic targets.

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2023 Mar 6

Kodam P, Sai Swaroop R, Pradhan SS

163. Machine learning-based CT radiomics model to discriminate the primary and secondary intracranial hemorrhage.

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2023 Mar 6

Lyu J, Xu Z, Sun H

164. Leukotriene A4 hydrolase (LTA4H rs17525495) gene polymorphisms and paradoxical reactions in extrapulmonary tuberculosis.

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2023 Mar 6

Kumar SS, Solomon R, Gautam P

165. Transcriptomic analysis of the cerebral hippocampal tissue in spontaneously hypertensive rats exposed to acute hypobaric hypoxia: associations with inflammation and energy metabolism.

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2023 Mar 6

Chang W(#), Cui J(#), Li Y

166. Risk factors and prediction model for inadvertent intraoperative hypothermia in patients undergoing robotic surgery: a retrospective analysis.

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2023 Mar 6

Hu Z(#), Li W(#), Liang C

167. Long-term changes in the choroidal thickness in patients with unilateral central retinal vein occlusion.

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2023 Mar 6

Hwang DD(#), Lee HJ(#).

168. Standardized pharmacological management of delirium after on-pump cardiac surgery reduces ICU stay and ventilation in a retrospective pre-post study.

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2023 Mar 6

Deininger MM, Schnitzler S, Benstoem C

Cardiac surgery patients not only undergo a highly invasive procedure but are at risk for a diversity of postoperative complications. Up to 53% of these patients suffer from postoperative delirium (POD). This severe and common adverse event increases mortality and prolonged mechanical ventilation and extends the intensive care unit stay. The objective of this study was to test the hypothesis that standardized pharmacological management of delirium (SPMD) may reduce the length of stay in the intensive care unit (ICU), duration of postoperative mechanical ventilation, and the incidence of postoperative complications such as pneumonia or bloodstream infections in on-pump cardiac surgery ICU patients. In this retrospective, single-center observational cohort study, 247 patients were examined between May 2018 to June 2020, who underwent on-pump cardiac surgery, suffered from POD, and received pharmacological POD treatment. 125 were treated before and 122 after SPMD implementation in the ICU. The primary endpoint was a composite outcome, including the length of ICU stay, postoperative mechanical ventilation time, and ICU survival rate. The secondary endpoints were complications including postoperative pneumonia and bloodstream infections. Although the ICU survival rate was not significantly different between both groups, the length of ICU stay (control group: 23 ± 27 days; SPMD group: 16 ± 16 days; p = 0.024) and the duration of mechanical ventilation were significantly reduced in the SPMD-cohort (control group: 230 ± 395 h; SPMD group: 128 ± 268 h; p = 0.022). Concordantly, the pneumonic risk was reduced after SPMD introduction (control group: 44.0%; SPMD group: 27.9%; p = 0.012) as well as the incidence for bloodstream infections (control group: 19.2%; SPMD group: 6.6%; p = 0.004). Standardized pharmacological management of postoperative delirium in on-pump cardiac surgery ICU patients reduced the length of ICU stay and duration of mechanical ventilation significantly, leading to a decrease in pneumonic complications and bloodstream infections.

169. Resculpting carbon dots via electrochemical etching.

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2023 Mar 6

Yang Q, Gavalas S, Ejsmont A

170. Artificial intelligence-aided method to detect uterine fibroids in ultrasound images: a retrospective study.

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2023 Mar 6

Huo T(#), Li L(#), Chen X

We explored a new artificial intelligence-assisted method to assist junior ultrasonographers in improving the diagnostic performance of uterine fibroids and further compared it with senior ultrasonographers to confirm the effectiveness and feasibility of the artificial intelligence method. In this retrospective study, we collected a total of 3870 ultrasound images from 667 patients with a mean age of 42.45 years ± 6.23 [SD] for those who received a pathologically confirmed diagnosis of uterine fibroids and 570 women with a mean age of 39.24 years ± 5.32 [SD] without uterine lesions from Shunde Hospital of Southern Medical University between 2015 and 2020. The DCNN model was trained and developed on the training dataset (2706 images) and internal validation dataset (676 images). To evaluate the performance of the model on the external validation dataset (488 images), we assessed the diagnostic performance of the DCNN with ultrasonographers possessing different levels of seniority. The DCNN model aided the junior ultrasonographers (Averaged) in diagnosing uterine fibroids with higher accuracy (94.72% vs. 86.63%, P < 0.001), sensitivity (92.82% vs. 83.21%, P = 0.001), specificity (97.05% vs. 90.80%, P = 0.009), positive predictive value (97.45% vs. 91.68%, P = 0.007), and negative predictive value (91.73% vs. 81.61%, P = 0.001) than they achieved alone. Their ability was comparable to that of senior ultrasonographers (Averaged) in terms of accuracy (94.72% vs. 95.24%, P = 0.66), sensitivity (92.82% vs. 93.66%, P = 0.73), specificity (97.05% vs. 97.16%, P = 0.79), positive predictive value (97.45% vs. 97.57%, P = 0.77), and negative predictive value (91.73% vs. 92.63%, P = 0.75). The DCNN-assisted strategy can considerably improve the uterine fibroid diagnosis performance of junior ultrasonographers to make them more comparable to senior ultrasonographers.

171. Comparative effects of desflurane and sevoflurane on intraoperative peripheral perfusion index: a retrospective, propensity score matched, cohort study.

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2023 Mar 6

Oh C(#), Lee S(#), Song BS

172. Exploring consumers' environmental ethical preferences in the context of unmanned aerial vehicle utilization for plant protection.

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2023 Mar 6

Wu B, Lu J, Zhou B(#)

173. Identification of a novel circRNA-miRNA-mRNA regulatory axis in hepatocellular carcinoma based on bioinformatics analysis.

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2023 Mar 6

Zhong G, Lin Y, Huang Z.

174. The impact of N-glycosylation on the properties of the antimicrobial peptide LL-III.

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2023 Mar 6

Tortorella A, Leone L, Lombardi A

175. First record of Jacobsoniidae (Coleoptera) on the African continent in Holocene copal from Tanzania: biogeography since the Cretaceous.

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2023 Mar 6

Peris D, Hammel JU, Cai C

176. Assessment of the variability of the morphological traits and differentiation of Cucurbita moschata in Cote d'Ivoire.

Sci Rep

2023 Mar 6

Seka D, Kouago BA, Bonny BS.

With its predisposition to adapt to different environments, Cucurbita moschata grows well in various ecosystems. It is not a very exigent plant and has an inherent capacity for plasticity that underlies its large variability. An assessment of the accessions of C. moschata in Cote d'Ivoire shows that the plant exhibits large morphological and phenological variability for all the 28 measured traits. There are outliers among most measured traits. Further analysis indicates the emergence of three ecotypes in congruence with the three distinct ecosystems and their respective bioclimatic characteristics. In the savannah region, characterized by a short rainy season followed by a long dry season, a total yearly rainfall of 900 mm, an elevated daily temperature of 29 °C, and a high relative humidity of 80%, the cline of C. moschata is long and thin, with small leaves, small peduncles and small fruits. It has a high growth rate and accelerated phenology. The mountain region has a very long rainy season followed by a short dry season, a total pluviometry of 1400 mm, an average daily temperature of 27 °C and a relative humidity of 69%. The cline of C. moschata in the mountain region is characterized by a delayed flowering and a delayed fruit maturity, large number of small seeds and large fruits. The forest region has a favorable climate for the growth of C. moschata in Cote d'Ivoire. It has two rainy seasons that alternate with two dry seasons of unequal durations, an annual rainfall of 1200 mm, an average daily temperature of 27 °C and a relative humidity of 70%. The cline of C. moschata in that region has a large girth size, large dimensions of the leaves, long peduncles and larger and heavier fruits. The seeds are also large but in small number. It appears that the anatomy and physiology of the clines are differentiated primarily in response to soil water content and availability for the ontogeny of the plant.

177. Long-term outcomes and quantitative radiologic analysis of extracranial-intracranial bypass for hemodynamically compromised chronic large artery occlusive disease.

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2023 Mar 6

Jo H, Lee SU, Jeong HG

178. Digitalization of hydraulic rotary drilling process for continuously mechanical profiling of siliciclastic sedimentary rocks.

Sci Rep

2023 Mar 6

Wang XF, Zhang ZJ, Yue WV

Hydraulic rotary drilling can offer the essential information and core samplesa for the researches on solid earth. Recording the factual field drilling data and analyzing the hydraulic rotary coring process are challenging yet promising to utilize the massive drilling information in geophysics and geology. This paper adopts the drilling process monitoring (DPM) technique and records the four parameters of displacement, thrust pressure, upward pressure, and rotation speed in real-time series for profiling the siliciclastic sedimentary rocks along 108 m deep drillhole. The digitalization results with 107 linear zones represent the spatial distribution of drilled geomaterials including superficial deposits (fill, loess, gravelly soil), mudstone, silty mudstone, gritstone, and fine sandstone. The constant drilling speeds varying from 0.018 to 1.905 m/min present the in-situ coring resistance of drilled geomaterials. Furthermore, the constant drilling speeds can identify the strength quality of soils to hard rocks. The thickness distributions of the six basic strength quality grades are presented for all the sedimentary rocks and each individual type of the seven soil and rocks. The in-situ strength profile determined in this paper can be used to assess and evaluate the in-situ mechanical behavior of geomaterial along the drillhole and can provide a new mechanical-based assessment for determining the spatial distribution of geological strata and structures in subsurface. They are important since the same stratum at different depths can have different mechanical behavior. The results provide a novel quantitative measurement for continuously in-situ mechanical profiling by digital drilling data. The findings of the paper can offer a new and effective method for refinement and upgrading of in-situ ground investigation, and can provide researchers and engineers with a novel tool and valuable reference to digitize and utilize factual data of current drilling projects.

179. Extinction drives a discontinuous temporal pattern of species-area relationships in a microbial microcosm system.

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2023 Mar 6

Deng W, Li N, Zhang CZ

180. Comparison of moderate-intensity continuous training and high-intensity interval training effects on the Ido1-KYN-Ahr axis in the heart tissue of rats with occlusion of the left anterior descending artery.

Sci Rep

2023 Mar 6

Nori P, Haghshenas R, Aftabi Y

Myocardial infarction (MI) affects many molecular pathways in heart cells, including the Ido1-KYN-Ahr axis. This pathway has recently been introduced as a valuable therapeutic target in infarction. We examined the effects of moderate-intensity continuous training (MICT) and high-intensity interval training (HIIT) on the axis in the heart tissue of male Wistar rats with occluded left anterior descending (OLAD). Thirty rats (age 10-12 weeks, mean weight 275 ± 25 g) were divided into five groups with 6 animals: Control (Ct) group, MICT group, rats with OLAD as MI group, rats with OLAD treated with MICT (MIMCT group) and rats with OLAD treated with HIIT (MIHIIT group). Rats performed the training protocols for 8 weeks, 5 days a week. HIIT included 7 sets of 4 min running with an intensity of 85-90% VO2max and 3 min of recovery activation between sets. MICT included continuous running at the same distance as HIIT with an intensity of 50-60% VO2max for 50 min. The expressions of Ahr, Cyp1a1, and Ido1 were assayed by real-time PCR. Malondialdehyde (MDA) and Kynurenine levels, and AHR, CYP1A1, and IDO1 proteins were detected using ELISA. Data were analyzed using the ANOVA and MANOVA tests. Compared to the CT group, MI caused an increase in all studied factors, but only statistically significant (P < 0.05) for MDA and IDO1. With a greater effect of HIIT, both protocols significantly lowered the proteins expressions in the MIHIIT and MIMCT groups, compared with the MI group (P < 0.001). In healthy rats, only AHR protein significantly decreased in the MICT group compared to the Ct group (P < 0.05). HIIT and MICT protocols significantly reduced the gene and protein expression of Cyp1a1 (P < 0.05) and Ido1 (P < 0.01), and HIIT had a greater effect. In conclusion, both protocols were effective at reducing the levels of Ido1-Kyn-Ahr axis components and oxidative stress in the infarcted heart tissue and HIIT had a higher significant effect.

181. Concussed patients with visually induced dizziness exhibit increased ocular torsion and vertical vergence during optokinetic gaze-stabilization.

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2023 Mar 6

Wibble T, Frattini D, Benassi M

182. Machine learning for detecting DNA attachment on SPR biosensor.

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2023 Mar 6

Mondal HS, Ahmed KA, Birbilis N

183. Gemcitabine-cisplatin versus MVAC chemotherapy for urothelial carcinoma: a nationwide cohort study.

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2023 Mar 6

Lee YS(#), Ha MS(#), Tae JH

184. Sex, age, role and geographic differences in traumatic spinal fractures caused by motor vehicle collisions: a multicentre retrospective study.

Sci Rep

2023 Mar 6

Yuan H(#), Guo Q(#), Zhang Z(#)

To investigate the sex, age, role and geographic differences in traumatic spinal fractures (TSFs) caused by motor vehicle collisions (MVCs) in adults (≥ 18 years old). This was a multicentre retrospective observational study. In total, 798 patients with TSFs caused by MVCs admitted to our hospitals from January 2013 to December 2019 were enrolled. The patterns were summarized with respect to different sexes (male and female), age group (18-60 and ≥ 60), role (driver, passenger and pedestrian) and geographic location (Chongqing and Shenyang). Significant differences in distribution related to district (p = 0.018), role (p < 0.01), motorcycle (p = 0.011), battery electric vehicle (p = 0.045), bicycle (p = 0.027), coma after injury (p = 0.002), pelvic fracture (p = 0.021), craniocerebral injury (p = 0.008) and fracture location (p < 0.01) were observed between the male and female groups. Significant differences in distribution related to district (p < 0.01), role (p < 0.01), car (p = 0.013), coma after injury (p = 0.003), lower limb fracture (p = 0.016), fracture location (p = 0.001) and spinal cord injury (p < 0.01) were observed between the young adult and elderly groups. Significant differences in distribution related to sex ratio (p < 0.01), age (p < 0.01), district (p < 0.01), most vehicles involved (P < 0.01), lower limb fracture (p < 0.01), pelvic fracture (p < 0.01), fracture location (p < 0.01), complications (p < 0.01), and spinal cord injury (p < 0.01) were observed between the three different groups of pedestrian, passenger, and driver. Significant differences in distribution related to sex ratio (p = 0.018), age (p < 0.01), role (p < 0.01), most vehicles involved (p < 0.01), coma after injury (p = 0.030), LLF (P = 0.002), pelvic fracture (p < 0.01), craniocerebral injury (p = 0.011), intrathoracic injury (p < 0.01), intra-abdominal injury (p < 0.01), complications (p = 0.033) and spinal cord injury (p < 0.01) were observed between the Chongqing and Shenyang groups. This study demonstrates the age-, gender-, role- and geographic-specific clinical characteristics of TSFs resulting from MVCs and reveals a significant relationship between different ages, sexes, roles, geographic locations and associated injuries, complications and spinal cord injuries.

185. Applying an ecosystem services framework on nature and mental health to recreational blue space visits across 18 countries.

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2023 Mar 6

Garrett JK, White MP, Elliott LR

186. The prevalence and risk factors for anxiety and depression symptoms among migrants in Morocco.

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2023 Mar 6

Essayagh F(#), Essayagh M(#), Essayagh S(#)

187. The first polarimetric GNSS-Reflectometer instrument in space improves the SMAP mission's sensitivity over densely vegetated areas.

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2023 Mar 6

Rodriguez-Alvarez N, Munoz-Martin JF, Bosch-Lluis X

188. Single-cell and bulk RNA sequencing identifies T cell marker genes score to predict the prognosis of pancreatic ductal adenocarcinoma.

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2023 Mar 6

Zheng H, Li Y, Zhao Y

Pancreatic ductal adenocarcinoma (PDAC) is one of the lethal malignancies, with limited biomarkers identified to predict its prognosis and treatment response of immune checkpoint blockade (ICB). This study aimed to explore the predictive ability of T cell marker genes score (TMGS) to predict their overall survival (OS) and treatment response to ICB by integrating single-cell RNA sequencing (scRNA-seq) and bulk RNA-seq data. Multi-omics data of PDAC were applied in this study. The uniform manifold approximation and projection (UMAP) was utilized for dimensionality reduction and cluster identification. The non-negative matrix factorization (NMF) algorithm was applied to molecular subtypes clustering. The Least Absolute Shrinkage and Selection Operator (LASSO)-Cox regression was adopted for TMGS construction. The prognosis, biological characteristics, mutation profile, and immune function status between different groups were compared. Two molecular subtypes were identified via NMF: proliferative PDAC (C1) and immune PDAC (C2). Distinct prognoses and biological characteristics were observed between them. TMGS was developed based on 10 T cell marker genes (TMGs) through LASSO-Cox regression. TMGS is an independent prognostic factor of OS in PDAC. Enrichment analysis indicated that cell cycle and cell proliferation-related pathways are significantly enriched in the high-TMGS group. Besides, high-TMGS is related to more frequent KRAS, TP53, and CDKN2A germline mutations than the low-TMGS group. Furthermore, high-TMGS is significantly associated with attenuated antitumor immunity and reduced immune cell infiltration compared to the low-TMGS group. However, high TMGS is correlated to higher tumor mutation burden (TMB), a low expression level of inhibitory immune checkpoint molecules, and a low immune dysfunction score, thus having a higher ICB response rate. On the contrary, low TMGS is related to a favorable response rate to chemotherapeutic agents and targeted therapy. By combining scRNA-seq and bulk RNA-seq data, we identified a novel biomarker, TMGS, which has remarkable performance in predicting the prognosis and guiding the treatment pattern for patients with PDAC.

189. Association between triglyceride to high-density lipoprotein cholesterol ratio and type 2 diabetes risk in Japanese.

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2023 Mar 6

Wang H, Wang C, Xuan X

190. The influence of solar-modulated regional circulations and galactic cosmic rays on global cloud distribution.

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2023 Mar 6

Kumar V, Dhaka SK, Hitchman MH

191. Changes in pacing variation with increasing race duration in ultra-triathlon races.

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2023 Mar 6

Stjepanovic M, Knechtle B, Weiss K

Despite the increasing scientific interest in the relationship between pacing and performance in endurance sports, little information is available about pacing and pacing variation in ultra-endurance events such as ultra-triathlons. Therefore, we aimed to investigate the trends of pacing, pacing variation, the influence of age, sex, and performance level in ultra-triathlons of different distances. We analysed 969 finishers (849 men, 120 women) in 46 ultra-triathlons longer than the original Ironman® distance (e.g., Double-, Triple-, Quintuple- and Deca Iron ultra-triathlons) held from 2004 to 2015. Pacing speed was calculated for every cycling and running lap. Pacing variation was calculated as the coefficient of variation (%) between the average speed of each lap. Performance level (i.e., fast, moderate, slow) was defined according to the 33.3 and 66.6 percentile of the overall race time. A multivariate analysis (two-way ANOVA) was applied for the overall race time as the dependent variable with 'sex' and 'age group' as independent factors. Another multivariate model with 'age' and 'sex' as covariates (two-way ANCOVA) was applied with pacing variation (cycling and running) as the dependent variable with 'race' and 'performance level' as independent factors. Different pacing patterns were observed by event and performance level. The general pacing strategy applied was a positive pacing. In Double and Triple Iron ultra-triathlon, faster athletes paced more evenly with less variation than moderate or slower athletes. The variation in pacing speed increased with the length of the race. There was no significant difference in pacing variation between faster, moderate, and slower athletes in Quintuple and Deca Iron ultra-triathlon. Women had a slower overall performance than men. The best overall times were achieved at the age of 30-39 years. Successful ultra-triathlon athletes adapted a positive pacing strategy in all race distances. The variation in pacing speed increased with the length of the race. In shorter ultra-triathlon distances (i.e., Double and Triple Iron ultra-triathlon), faster athletes paced more evenly with less variation than moderate or slower athletes. In longer ultra-triathlon distances (i.e., Quintuple and Deca Iron ultra-triathlon), there was no significant difference in pacing variation between faster, moderate, and slower athletes.

192. Effects of fermented soybean meal supplementation on the growth performance and apparent total tract digestibility by modulating the gut microbiome of weaned piglets.

Sci Rep

2023 Mar 6

Muniyappan M(#), Shanmugam S(#), Park JH

This study investigates the effects of soybean meal fermented by Enterococcus faecium as a replacement for soybean meal on growth performance, apparent total tract digestibility, blood profile and gut microbiota of weaned pigs. Eighty piglets (weaned at 21 days) [(Landrace × Yorkshire) × Duroc] with average body weight of 6.52 ± 0.59 kg) were selected and assigned to 4 treatments/4 replicate pens (3 barrows and 2 gilts). The four diets (SBM, 3, 6 and 9% FSBM) were formulated using fermented soybean meal to replace 0, 3, 6 and 9% of soybean meal, respectively. The trial lasted for 42 days phase 1, 2 and 3. Result showed that supplemental FSBM increased (P < 0.05) the body weight gain (BWG) of piglets at day 7, 21 and 42 and ADG at days 1-7, 8-21, 22-42 and 1-42, and ADFI at days 8-21, 22-42 and 1-42 and G: F at days 1-7, 8-21 and 1-42, and crude protein, dry matter, and gross energy digestibility at day 42, and lowered (P < 0.05) diarrhea at days 1-21 and 22-42. The concentration of glucose levels, WBC, RBC, and lymphocytes were increased while, concentration of BUN level in the serum was lowered in the FSBM treatment compared to the SBM group (P < 0.05). Microbiota sequencing found that FSBM supplementation increased the microbial Shannon, Simpsons and Chao indexs, (P < 0.05) and the abundances of the phylum Firmicutes, and genera prevotella, Lactobacillus, Lachnospiraceae and Lachnoclostridium (P < 0.05), lower in the abundances of the phylum bacteroidetes, Proteobacteria, genera Escherichia-Shigella, Clostridium sensu stricto1, Bacteroides and Parabacteroides (P < 0.05). Overall, FSBM replacing SBM improved the growth performance, apparent total tract digestibility, and blood profiles; perhaps via altering the faecal microbiota and its metabolites in weaned pigs. The present study provides theoretical support for applying FSBM at 6-9% to promote immune characteristics and regulate intestinal health in weaning piglets.

193. CRISPR/Cas9 mediated specific ablation of vegfa in retinal pigment epithelium efficiently regresses choroidal neovascularization.

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2023 Mar 6

Park J(#), Cui G(#), Lee H

194. Data driven contagion risk management in low-income countries using machine learning applications with COVID-19 in South Asia.

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2023 Mar 6

Shonchoy AS, Mahzab MM, Mahmood TI

195. Toward low-loss mid-infrared Ga(2)O(3)-BaO-GeO(2) optical fibers.

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2023 Mar 6

Guérineau T, Aouji S, Morency S

196. Mapping the immune landscape in small cell lung cancer by analysing expression of immuno-modulators in tissue biopsies and paired blood samples.

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2023 Mar 6

Dutta R, Rathor A, Sharma HP

197. A novel molecular imaging probe [(99m)Tc]Tc-HYNIC-FAPI targeting cancer-associated fibroblasts.

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2023 Mar 6

Jiang Y, Tian Y, Feng B

198. Universal compilation for quantum state tomography.

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2023 Mar 6

Hai VT, Ho LB.

199. Pattern-based hybrid book recommendation system using semantic relationships.

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2023 Mar 6

Wayesa F, Leranso M, Asefa G

200. A multicenter phase II trial of anti-EGFR-immunoliposomes loaded with doxorubicin in patients with advanced triple negative breast cancer.

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2023 Mar 6

Mamot C(#), Wicki A(#), Hasler-Strub U

201. Ontogenetic changes in the body structure of the Arctic fish Leptoclinus maculatus.

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2023 Mar 6

Pekkoeva SN, Kondakova EA, Falk-Petersen S

202. Ex vivo expansion of circulating tumour cells (CTCs).

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2023 Mar 6

Mohamed BM, Ward MP, Bates M

203. Smoke dispersion test and emergency control plan of fire in mine roadway during downward ventilation.

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2023 Mar 6

Hu D, Li Z, Wang H

204. Characterization of permanent deformation properties of densely-compacted unbound granular materials subjected to cyclic loading.

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2023 Mar 6

Liu G, Zhao M, Luo Q

205. Entropic analysis of cilia-modulated slip flow of trimetallic nanofluid through electroosmotic corrugated pump in the presence of inclined magnetic field.

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2023 Mar 6

Munawar S, Saleem N, Afzal F

206. The role of SMAD signaling in hypertrophic obstructive cardiomyopathy: an immunohistopathological study in pediatric and adult patients.

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2023 Mar 6

Zhang Z(#), Zhang F(#), Zhang M

207. No impact of nitrogen fertilization on carbon sequestration in a temperate Pinus densiflora forest.

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2023 Mar 6

Baek G(#), Lim H(#), Noh NJ

208. Grid-wise simulation acceleration of the electromagnetic fields of 2D optical devices using super-resolution.

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2023 Mar 6

Seo J, Kim I, Seok J.

209. Type 2 diabetes prevalence, awareness, and risk factors in rural Mali: a cross-sectional study.

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2023 Mar 6

Diawara A, Coulibaly DM, Hussain TYA

210. Pneumonitis associated with pembrolizumab plus chemotherapy for non-squamous non-small cell lung cancer.

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2023 Mar 6

Fujimoto D, Miura S, Tomii K

211. Unfounded authority, underpowered studies, and non-transparent reporting perpetuate the Mozart effect myth: a multiverse meta-analysis.

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2023 Mar 6

Oberleiter S, Pietschnig J.

212. Pseudomonas alcaliphila NEWG-2 as biosorbent agent for methylene blue dye: optimization, equilibrium isotherms, and kinetic processes.

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2023 Mar 5

Ghoniem AA, Moussa Z, Alenzi AM

In comparison to physicochemical and chemical methods, microbial dye biosorption is regarded as an eco-effective and economically viable alternative and is a widely applied method due to its high efficiency and compatibility with the environment. Therefore, the idea of this study is to clarify to what extent the viable cells and the dry biomass of Pseudomonas alcaliphila NEWG-2 can improve the biosorption of methylene blue (MB) from a synthetic wastewater sample. The array of Taguchi paradigm has been conducted to ascertain five variables affecting the biosorption of MB by broth forms of P. alcaliphila NEWG. The data of MB biosorption were familiar to the predicted ones, indicating the precision of the Taguchi model's prediction. The maximum biosorption of MB (87.14%) was achieved at pH 8, after 60 h, in a medium containing 15 mg/ml MB, 2.5% glucose, and 2% peptone, with sorting the highest signal-to-noise ratio (38.80). FTIR spectra detected various functional groups (primary alcohol, α, β-unsaturated ester, symmetric NH2 bending, and strong C-O stretching) on the bacterial cell wall that participated in the biosorption of MB. Furthermore, the spectacular MB biosorption ability was validated by equilibrium isotherms and kinetic studies (the dry biomass form), which were derived from the Langmuir model (qmax = 68.827 mg/g). The equilibrium time was achieved in about 60 min, with 70.5% of MB removal. The biosorption kinetic profile might be adequately represented by pseudo-second order and Elovich models. The changes in the bacterial cells before and after the biosorption of MB were characterized using a scanning electron microscope. As realized from the aforementioned data, the bacterium is a talented, effective, eco-friendly, and low-cost bio-sorbent for the decolorization and remedy of an industrial effluent containing MB from an aqueous environment. The current outcomes in the biosorption of MB molecules promote the use of the bacterial strain as viable cells and/or dry biomass in ecosystem restoration, environmental cleanup, and bioremediation studies.

Sci Rep

2023 Mar 4

Mansour A, Motamed S, Hekmatdoost A

Considering the progressive prevalence and co-occurrence of type 2 diabetes mellitus (T2DM) and non-alcoholic fatty liver disease (NAFLD), as well as the current evidence suggesting the elevated levels of basal metabolic rate (BMR) among these individuals, the present study aimed to identify factors determining hypermetabolism in such subjects. This cross sectional study was conducted in 30 to 53-year-old individuals with concurrent T2DM and NAFLD (controlled attenuation parameter score ≥ 260 dB/m). Resting energy expenditure (REE) was determined by an indirect calorimetry device. Hypermetabolism was defined as an elevated measured REE > 110% of the predicted REE. The multivariate logistic regression test was used for detecting factors associated with hypermetabolism. Between September, 2017, and March, 2018, a total of 95 eligible participants (64.40% male) with both T2DM and NAFLD were included, while 32.63% of them were classified as hypermetabolic. Overall, the mean recruitment age ± standard deviation and median (interquartile range) body mass index were 44.69 ± 5.47 years and 30.20 (27.80-33.30) kg/m2, respectively. Demographic, anthropometric and biochemical variables did not vary significantly across two groups except for total body water, low-density lipoprotein cholesterol and dipeptidyl peptidase 4 (DPP-4) inhibitors (p < 0.05). According to the results of multivariable logistic regression analyses, hypermetabolism had a positive association with adiponectin (odds ratio [OR] 1.167, 95% confidence interval [CI] 1.015-1.342, p = 0.030), physical activity (OR 1.134, 95% CI 1.002-1.284, p = 0.046), alanine transaminase (OR 1.062, 95% CI 1.006-1.122, p = 0.031) and diastolic blood pressure (OR 1.067, 95% CI 1.010-1.127, p = 0.021). However, fat free mass was inversely related to hypermetabolism (OR 0.935, 95% CI 0.883-0.991, p = 0.023). Adiponectin, alanine transaminase, physical activity, diastolic blood pressure and fat free mass were independently associated with hypermetabolism in subjects with NAFLD and T2DM.

214. Allergic rhinitis children with obesity are more vulnerable to air pollution: a cross sectional study.

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2023 Mar 4

Li RL(#), Wu CT(#), Chen SM

215. Efficacy of resistance training in hypoxia on muscle hypertrophy and strength development: a systematic review with meta-analysis.

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2023 Mar 4

Benavente C, Schoenfeld BJ, Padial P

216. Pulmonary function in patients with transfusion-dependent thalassemia and its associations with iron overload.

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2023 Mar 4

Chan KC(#), Au CT(#), Leung AWK

In patients with transfusion-dependent thalassemia (TDT), pulmonary function impairment has been reported but data are conflicting. Moreover, it remains unclear whether pulmonary dysfunction is associated with iron overload. This study aimed to evaluate the pulmonary function in patients with TDT and to investigate the associations between pulmonary dysfunction and iron overload. It was a retrospective observational study. 101 patients with TDT were recruited for lung function tests. The most recent ferritin levels (pmol/L) and the magnetic resonance imaging (MRI) measurements of the myocardial and liver iron status, as measured by heart and liver T2* relaxation time (millisecond, ms) respectively, were retrieved from the computerized medical records. Only data within 12 months from the lung function measurement were included in the analysis. The serum ferritin, and the cardiac and liver T2* relaxation time were the surrogate indexes of body iron content. The threshold of abnormality in lung function was defined as under 80% of the predicted value. 101 subjects were recruited with a mean age of 25.1 years (standard deviation (SD) 7.9 years). Thirty-eight (38%) and five (5%) demonstrated restrictive and obstructive lung function deficits, respectively. A weak correlation of FVC %Predicted and TLC %Predicted with MRI myocardial T2* relaxation time (rho = 0.32, p = 0.03 and rho = 0.33, p = 0.03 respectively) was observed. By logistic regression, MRI cardiac T2* relaxation time was negatively associated with restrictive lung function deficit (B - 0.06; SE 0.03; Odds ratio 0.94; 95% confidence interval (CI) 0.89-0.99; p = 0.023) after adjusting for age, sex and body mass index. Restrictive pulmonary function deficit was commonly observed in patients with TDT, and the severity potentially correlates with myocardial iron content. Monitoring of lung function in this group of patients, particularly for those with iron overload, is important.

217. Identification of m6A/m5C/m1A-associated LncRNAs for prognostic assessment and immunotherapy in pancreatic cancer.

Sci Rep

2023 Mar 4

Huang Y, Zhang W, Li Q

Methylation of RNA plays an important role in cancer. Classical forms of such modifications include N6-methyladenine (m6A), 5-methylcytosine (m5C), and N1-methyladenine (m1A). Methylation-regulated long non-coding (lnc) RNAs are involved in various biological processes, such as tumor proliferation, apoptosis, immune escape, invasion, and metastasis. Therefore, we performed an analysis of transcriptomic and clinical data of pancreatic cancer samples in The Cancer Genome Atlas (TCGA). Using the co-expression method, we summarized 44 m6A/m5C/m1A-related genes and obtained 218 methylation-associated lncRNAs. Next, with COX regression, we screened 39 lncRNAs that are strongly associated with prognosis and found that their expression differed significantly between normal tissues and pancreatic cancer samples (P < 0.001). We then used the least absolute shrinkage and selection operator (LASSO) to construct a risk model comprising seven lncRNAs. In validation set, the nomogram generated by combining clinical characteristics accurately predicted the survival probability of pancreatic cancer patients at 1, 2, and 3 years after diagnosis (AUC = 0.652, 0.686, and 0.740, respectively). Tumor microenvironment analysis showed that the high-risk group had significantly more resting memory CD4 T cells, M0 macrophages, and activated dendritic cells and fewer naïve B cells, plasma cells, and CD8 T cells than the low-risk group (both P < 0.05). Most immune-checkpoint genes were significantly different between the high- and low-risk groups (P < 0.05). The Tumor Immune Dysfunction and Exclusion score showed that high-risk patients benefited more from treatment with immune checkpoint inhibitors (P < 0.001). Overall survival was also lower in high-risk patients with more tumor mutations than in low-risk patients with fewer mutations (P < 0.001). Finally, we explored the sensitivity of the high- and low-risk groups to seven candidate drugs. Our findings indicated that m6A/m5C/m1A-associated lncRNAs are potentially useful biomarkers for the early diagnosis and estimating the prognosis of, and ascertaining the responses to immunotherapy in, patients with pancreatic cancer.

218. Optomechanically induced gain using a trapped interacting Bose-Einstein condensate.

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2023 Mar 4

Mikaeili H, Dalafi A, Ghanaatshoar M

219. Hard optimization problems have soft edges.

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2023 Mar 4

Marino R, Kirkpatrick S.

220. Impact of the Tambora volcanic eruption of 1815 on islands and relevance to future sunlight-blocking catastrophes.

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2023 Mar 4

Wilson N, Valler V, Cassidy M

Island nations may have potential long-term survival value for humanity in global catastrophes such as sun-blocking catastrophes from nuclear winter and large magnitude volcanic eruptions. One way to explore this issue further is to understand the impact on islands after the largest historically observed volcanic eruption: that of Mt Tambora in 1815. For each of the 31 large, populated islands selected, we conducted literature searches for relevant historical and palaeoclimate studies. We also analysed results from a reconstruction (EKF400v2), which uses atmospheric-only general circulation model simulations with assimilated observational and proxy data. From the literature review, there was widespread evidence for weather/climate anomalies in 1815-1817 for these islands (29/29 for those with data). But missing data was an issue for other dimensions such as impaired food production (seen in 8 islands out of only 12 with data). Based on the EKF400v2 reconstruction for temperature anomalies (compared to the relatively "non-volcanic" reference period of 1779 to 1808), the islands had lower temperature anomalies in the 1815-1818 period than latitudinally equivalent continental sites (at 100 km and 1000 km inland). This was statistically significant for the great majority of the comparisons for group analyses by hemisphere, oceans, and temperate/tropical zone. When considering just the islands, all but four showed statistically anomalous temperature reductions in the 1816-1817 period (for most p < 0.00001). In the peak impact year of 1816, the lowest anomalies were seen for islands in the Southern Hemisphere (p < 0.0001), the Indian Ocean (p < 0.0001), and in the tropics and subtropics of the Southern Hemisphere (p = 0.0057). In conclusion, the findings of both the literature review and reconstruction simulations suggest climatic impacts of the Tambora eruption for nearly all these 31 large islands, albeit less than for continental sites. Islands with the smallest temperature anomalies were in the Southern Hemisphere, in particular the Indian Ocean and the tropics and subtropics of the Southern Hemisphere.

221. The deep origin of ground fissures in the Kenya Rift Valley.

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2023 Mar 4

Jia Z, Wu H, Peng J

222. Standard of care drugs do not modulate activity of senescent primary human lung fibroblasts.

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2023 Mar 4

Badaro-Garcia S, Hohmann MS, Coelho AL

223. Nanobubble size distribution measurement by interactive force apparatus under an electric field.

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2023 Mar 4

Han Z, Chen H, He C

224. Biomimetic cultivation of atrial tissue slices as novel platform for in-vitro atrial arrhythmia studies.

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2023 Mar 4

Amesz JH, de Groot NMS, Langmuur SJJ

225. Direct competition and potential displacement involving managed Trogoderma stored product pests.

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2023 Mar 4

Domingue MJ, Wu Y, Vieira KA

226. The importance of high quality real-life social interactions during the COVID-19 pandemic.

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2023 Mar 4

Monninger M, Aggensteiner PM, Pollok TM

227. Development of a nomogram for predicting 90-day mortality in patients with sepsis-associated liver injury.

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2023 Mar 4

Cui L, Bao J, Yu C

The high mortality rate in sepsis patients is related to sepsis-associated liver injury (SALI). We sought to develop an accurate forecasting nomogram to estimate individual 90-day mortality in SALI patients. Data from 34,329 patients were extracted from the public Medical Information Mart for Intensive Care (MIMIC-IV) database. SALI was defined by total bilirubin (TBIL) > 2 mg/dL and the occurrence of an international normalized ratio (INR) > 1.5 in the presence of sepsis. Logistic regression analysis was performed to establish a prediction model called the nomogram based on the training set (n = 727), which was subsequently subjected to internal validation. Multivariate logistic regression analysis showed that SALI was an independent risk factor for mortality in patients with sepsis. The Kaplan‒Meier curves for 90-day survival were different between the SALI and non-SALI groups after propensity score matching (PSM) (log rank: P < 0.001 versus P = 0.038), regardless of PSM balance. The nomogram demonstrated better discrimination than the sequential organ failure assessment (SOFA) score, logistic organ dysfunction system (LODS) score, simplified acute physiology II (SAPS II) score, and Albumin-Bilirubin (ALBI) score in the training and validation sets, with areas under the receiver operating characteristic curve (AUROC) of 0.778 (95% CI 0.730-0.799, P < 0.001) and 0.804 (95% CI 0.713-0.820, P < 0.001), respectively. The calibration plot showed that the nomogram was sufficiently successful to predict the probability of 90-day mortality in both groups. The DCA of the nomogram demonstrated a higher net benefit regarding clinical usefulness than SOFA, LODS, SAPSII, and ALBI scores in the two groups. The nomogram performs exceptionally well in predicting the 90-day mortality rate in SALI patients, which can be used to assess the prognosis of patients with SALI and may assist in guiding clinical practice to enhance patient outcomes.

228. Urban economic fitness and complexity from patent data.

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2023 Mar 4

Straccamore M, Bruno M, Monechi B

229. Multi-resonant tessellated anchor-based metasurfaces.

Sci Rep

2023 Mar 4

Gallagher CP, Hamilton JK, Hooper IR

230. Genome-wide identification, characterization and expression analysis of AGO, DCL, and RDR families in Chenopodium quinoa.

Sci Rep

2023 Mar 4

Yun S, Zhang X.

231. Feasibility and intra-and interobserver reproducibility of quantitative susceptibility mapping with radiomic features for intracranial dissecting intramural hematomas and atherosclerotic calcifications.

Sci Rep

2023 Mar 4

Park SI(#), Kim D(#), Jung SC

232. Organic carbon accumulation and aggregate formation in soils under organic and inorganic fertilizer management practices in a rice-wheat cropping system.

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2023 Mar 4

Zhao Z, Mao Y, Gao S

Soil organic carbon (C) and aggregates are the important components of soil fertility and the foundation of sustainable agriculture. The storage and protection of SOC in aggregates is widely regarded as the material basis of soil organic C accumulation. However, current understanding of soil aggregate and its associated organic C is insufficient to elucidate the regulation mechanism of soil organic C. A nine-year field experiment including chemical fertilizer (FR) and organic manure (OM) treatments was set up in the eastern plain of Funiu Mountain, central China. Using chemical analysis, physical sieving as well as nuclear magnetic resonance (NMR) methods, we mainly probed into the response of soil organic C concentration and composition, and C functional groups, water-stable aggregates to different treatments. Furthermore, scanning electronic microscopy (SEM) and partial least square structural equation modelling (PLS-SEM) was conducted to characterise the different size aggregates and to analyse the mechanism of soil organic C accumulation and stabilisation at aggregate scales. After nine years of farming, OM treatment substantially increased soil organic C content (by 3.77 g kg-1) and significantly enhanced the formation of macro-aggregates (> 250 μm), while FR had no significant influence on soil organic C. At the aggregate scale, the amounts of soil organic C, C physical fractions (particulate and mineral-associated organic C), total nitrogen and microbial biomass carbon associated in macro-aggregates (> 250 μm) were obviously higher than that in micro-aggregates and silt + clay fraction, and OM treatment greatly increased the accumulation of soil organic C and its components in macro-aggregates. Moreover, microbial biomass carbon (MBC) amounts in aggregates were remarkably increased (27-116%) by the application of OM. And MBC had a positively effect on the physical fractions of SOC but not on the C chemical structure within aggregates. The present study indicated that soil organic C accumulation mainly rely on macro-aggregates (> 250 μm). Intra-particulate organic carbon (POC) and mineral-associated organic carbon (MOC) within macro-aggregates played an important role in soil organic C accumulation. Meanwhile, soil microbes were a driving force for the accumulation of soil organic C physical fractions (POC and MOC). We concluded that OM treatment accelerated the synergistic process between organic C sequestration and soil aggregation, and showed great potential to increase soil organic C accumulation.

233. Local environment drives rapid shifts in composition and phylogenetic clustering of seagrass microbiomes.

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2023 Mar 4

Kardish MR, Stachowicz JJ.

234. Denser forests across the USA experience more damage from insects and pathogens.

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2023 Mar 4

Asaro C(#), Koch FH(#), Potter KM.

235. Recycling micro polypropylene in modified hot asphalt mixture.

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2023 Mar 4

Buruiana DL, Georgescu PL, Carp GB

236. Molecular-evaluated and explainable drug repurposing for COVID-19 using ensemble knowledge graph embedding.

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2023 Mar 4

Islam MK, Amaya-Ramirez D, Maigret B

237. Biosynthesis of silver nanoparticles using Pseudomonas canadensis, and its antivirulence effects against Pseudomonas tolaasii, mushroom brown blotch agent.

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2023 Mar 4

Ghasemi S, Harighi B, Ashengroph M.

238. Assessment of surface and electrical properties of the TiO(2)@zeolite hybrid materials.

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2023 Mar 4

Supelano GI, Mesa F, Vargas CAP

239. Expression of SPAG7 and its regulatory microRNAs in seminal plasma and seminal plasma-derived extracellular vesicles of patients with subfertility.

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2023 Mar 4

Abu-Halima M(#), Becker LS(#), Al Smadi MA

240. Neural network based formation of cognitive maps of semantic spaces and the putative emergence of abstract concepts.

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2023 Mar 4

Stoewer P, Schilling A, Maier A

How do we make sense of the input from our sensory organs, and put the perceived information into context of our past experiences? The hippocampal-entorhinal complex plays a major role in the organization of memory and thought. The formation of and navigation in cognitive maps of arbitrary mental spaces via place and grid cells can serve as a representation of memories and experiences and their relations to each other. The multi-scale successor representation is proposed to be the mathematical principle underlying place and grid cell computations. Here, we present a neural network, which learns a cognitive map of a semantic space based on 32 different animal species encoded as feature vectors. The neural network successfully learns the similarities between different animal species, and constructs a cognitive map of 'animal space' based on the principle of successor representations with an accuracy of around 30% which is near to the theoretical maximum regarding the fact that all animal species have more than one possible successor, i.e. nearest neighbor in feature space. Furthermore, a hierarchical structure, i.e. different scales of cognitive maps, can be modeled based on multi-scale successor representations. We find that, in fine-grained cognitive maps, the animal vectors are evenly distributed in feature space. In contrast, in coarse-grained maps, animal vectors are highly clustered according to their biological class, i.e. amphibians, mammals and insects. This could be a putative mechanism enabling the emergence of new, abstract semantic concepts. Finally, even completely new or incomplete input can be represented by interpolation of the representations from the cognitive map with remarkable high accuracy of up to 95%. We conclude that the successor representation can serve as a weighted pointer to past memories and experiences, and may therefore be a crucial building block to include prior knowledge, and to derive context knowledge from novel input. Thus, our model provides a new tool to complement contemporary deep learning approaches on the road towards artificial general intelligence.

241. Unfamiliar face matching ability predicts the slope of face learning.

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2023 Mar 31

Baker KA, Mondloch CJ.

242. Environmental-friendly regenerated lignocellulose functionalized cotton fabric to prepare multi-functional degradable membrane for efficient oil-water separation and solar seawater desalination.

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2023 Mar 31

Li J, Gao J, Fang J

243. Covid-19 pandemic induced traumatizing medical job contents and mental health distortions of physicians working in private practices and in hospitals.

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2023 Mar 31

Ladwig KH, Johar H, Miller I

244. First osteological evidence of severed hands in Ancient Egypt.

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2023 Mar 31

Gresky J, Bietak M, Petiti E

245. Numerical approach for flexible body with internal boundary movement.

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2023 Mar 31

Ogawara R, Kaczmarczyk S, Terumichi Y.

246. Assessment of pathogenic variation in gynecologic cancer genes in a national cohort.

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2023 Mar 31

Kotnik U, Maver A, Peterlin B

247. Identification of PARN nuclease activity inhibitors by computational-based docking and high-throughput screening.

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2023 Mar 31

Huynh TN, Shukla S, Reigan P

248. Effect of Ag modification on TiO(2) and melem/g-C(3)N(4) composite on photocatalytic performances.

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2023 Mar 31

Michalska M, Matějka V, Pavlovský J

249. The role of cognitive flexibility in moderating the effect of school-related stress exposure.

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2023 Mar 31

Harel O, Hemi A, Levy-Gigi E.

250. A clinical decision support system for AI-assisted decision-making in response-adaptive radiotherapy (ARCliDS).

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2023 Mar 31

Niraula D, Sun W, Jin J

Involvement of many variables, uncertainty in treatment response, and inter-patient heterogeneity challenge objective decision-making in dynamic treatment regime (DTR) in oncology. Advanced machine learning analytics in conjunction with information-rich dense multi-omics data have the ability to overcome such challenges. We have developed a comprehensive artificial intelligence (AI)-based optimal decision-making framework for assisting oncologists in DTR. In this work, we demonstrate the proposed framework to Knowledge Based Response-Adaptive Radiotherapy (KBR-ART) applications by developing an interactive software tool entitled Adaptive Radiotherapy Clinical Decision Support (ARCliDS). ARCliDS is composed of two main components: Artifcial RT Environment (ARTE) and Optimal Decision Maker (ODM). ARTE is designed as a Markov decision process and modeled via supervised learning. Given a patient's pre- and during-treatment information, ARTE can estimate treatment outcomes for a selected daily dosage value (radiation fraction size). ODM is formulated using reinforcement learning and is trained on ARTE. ODM can recommend optimal daily dosage adjustments to maximize the tumor local control probability and minimize the side effects. Graph Neural Networks (GNN) are applied to exploit the inter-feature relationships for improved modeling performance and a novel double GNN architecture is designed to avoid nonphysical treatment response. Datasets of size 117 and 292 were available from two clinical trials on adaptive RT in non-small cell lung cancer (NSCLC) patients and adaptive stereotactic body RT (SBRT) in hepatocellular carcinoma (HCC) patients, respectively. For training and validation, dense data with 297 features were available for 67 NSCLC patients and 110 features for 71 HCC patients. To increase the sample size for ODM training, we applied Generative Adversarial Networks to generate 10,000 synthetic patients. The ODM was trained on the synthetic patients and validated on the original dataset. We found that, Double GNN architecture was able to correct the nonphysical dose-response trend and improve ARCliDS recommendation. The average root mean squared difference (RMSD) between ARCliDS recommendation and reported clinical decisions using double GNNs were 0.61 [0.03] Gy/frac (mean [sem]) for adaptive RT in NSCLC patients and 2.96 [0.42] Gy/frac for adaptive SBRT HCC compared to the single GNN's RMSDs of 0.97 [0.12] Gy/frac and 4.75 [0.16] Gy/frac, respectively. Overall, For NSCLC and HCC, ARCliDS with double GNNs was able to reproduce 36% and 50% of the good clinical decisions (local control and no side effects) and improve 74% and 30% of the bad clinical decisions, respectively. In conclusion, ARCliDS is the first web-based software dedicated to assist KBR-ART with multi-omics data. ARCliDS can learn from the reported clinical decisions and facilitate AI-assisted clinical decision-making for improving the outcomes in DTR.

251. Possible correlation of apical localization of MUC1 glycoprotein with luminal A-like status of breast cancer.

Sci Rep

2023 Mar 31

Semba R, Horimoto Y, Sakata-Matsuzawa M

Adjuvant chemotherapy has played a major role in the treatment of hormone receptor-positive breast cancer for many years. To better determine which patient subsets need adjuvant chemotherapy, various gene expression analyses have been developed, but cost-effective tools to identify such patients remain elusive. In the present report, we retrospectively investigated immunohistochemical expression and subcellular localization of MUC1 in primary tumors and examined their relationship to tumor malignancy, chemotherapy effect and patient outcomes. We retrospectively examined three patient cohorts with hormone receptor-positive/human epidermal growth factor receptor 2-negative invasive breast cancer: 51 patients who underwent 21-gene expression analysis (multi-gene assay-cohort), 96 patients who received neoadjuvant chemotherapy (neoadjuvant chemotherapy-cohort), and 609 patients whose tumor tissue was used in tissue-microarrays (tissue-microarray-cohort). The immunohistochemical staining pattern of the anti-MUC1 monoclonal antibody, Ma695, was examined in cancer tissues, and subcellular localization was determined as apical, cytoplasmic or negative. In the multi-gene assay-cohort, tumors with apical patterns had the lowest recurrence scores, reflecting lower tumor malignancy, and were significantly lower than MUC1-negative tumors (P = 0.038). In the neoadjuvant chemotherapy-cohort, there was no correlation between MUC1 staining patterns and effects of chemotherapy. Finally, in the tissue-microarray-cohort, we found that patients with apical MUC1 staining patterns had significantly longer disease-free-survival and overall survival than other patterns (P = 0.020 and 0.039, respectively). Our data suggest that an apical MUC1 staining pattern indicates luminal A-likeness. Assessment of the subcellular localization of MUC1 glycoprotein may be useful for identifying patients who can avoid adjuvant chemotherapy.

252. Prevalence of chronic pain in hemodialysis patients and its correlation with C-reactive protein: a cross-sectional study.

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2023 Mar 31

Mizher A, Hammoudi H, Hamed F

End-stage renal disease (ESRD) is a common chronic disease worldwide that requires hemodialysis. Patients may face chronic pain and poor quality of life. Therefore, a better understanding of these variables in hemodialysis patients is essential to provide a good intervention. We aim to determine how common chronic pain is in hemodialysis patients and its correlation with sociodemographics, C-reactive protein (CRP), calcium, phosphorus, albumin, and parathyroid hormone. A cross-sectional study of hemodialysis patients was conducted in Palestine. Data collection took place between November 2020 and May 2021. We used the brief pain inventory score to assess chronic pain, and lab tests detected CRP levels. Data were collected using a convenience sampling technique. There were two hundred sixty-one patients in the present study. The mean age of the patients was 51 years, with 63.6% being men. 47.1% of them reported having chronic pain. Gender (p = 0.011), social status (p = 0.003), educational status (p = 0.010), and number of chronic diseases (p = 0.004) indicated a significant relationship with the severity score of pain. Furthermore, sex (p = 0.011), social status (p = 0.003), and number of chronic diseases (p = 0.002) were significantly associated with the pain interference score. Additionally, Person's test indicated significant correlations between CRP and pain severity (p < 0.001) and with pain interference (p < 0.001). Albumin was significantly and negatively correlated with pain severity (p = 0.001) and pain interference (p < 0.001). Multiple linear regression analysis revealed that patients who had a higher CRP level and many chronic diseases were more likely to have a higher pain severity score. However, pain severity was the only predictor for pain interference. Our results suggest that there is a significant correlation between the existence of chronic pain in hemodialysis patients and increased CRP levels. However, further investigations are needed with a larger number of patients in more than one dialysis unit to confirm this correlation and management of chronic pain in patients with HD.

253. Complete genome analysis of African swine fever virus genotypes II, IX and XV from domestic pigs in Tanzania.

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2023 Mar 31

Hakizimana JN, Yona C, Makange MR

254. Agent-based null models for examining experimental social interaction networks.

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2023 Mar 31

Fennell SC, Gleeson JP, Quayle M

255. Antimicrobial activity and comparative metabolomic analysis of Priestia megaterium strains derived from potato and dendrobium.

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2023 Mar 31

Liu JM(#), Liang YT(#), Wang SS

256. Iron deficiency in sepsis patients managed with divided doses of iron dextran: a prospective cohort study.

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2023 Mar 31

Czempik PF, Wiórek A.

257. Facies evaluation and sedimentary environments of the Yamama Formation in the Ratawi oil field, South Iraq.

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2023 Mar 31

Al-Iessa IA, Zhang WZ.

258. Passive atomic-scale optical sensors for mapping light flux in ultra-small cavities.

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2023 Mar 31

Andričević P, Sellwood EL, Eppes MC

259. Spherical alveolar shapes in live mouse lungs.

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2023 Mar 31

Kim MW, Weon BM, Je JH.

260. Determinants of people's motivations to approach COVID-19 vaccination centers.

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2023 Mar 31

Keser C(#), Rau HA(#).

261. Dental image enhancement network for early diagnosis of oral dental disease.

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2023 Mar 31

Khan R, Akbar S, Khan A

262. Genetic correlations between Alzheimer's disease and gut microbiome genera.

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2023 Mar 31

Cammann D(#), Lu Y(#), Cummings MJ

A growing body of evidence suggests that dysbiosis of the human gut microbiota is associated with neurodegenerative diseases like Alzheimer's disease (AD) via neuroinflammatory processes across the microbiota-gut-brain axis. The gut microbiota affects brain health through the secretion of toxins and short-chain fatty acids, which modulates gut permeability and numerous immune functions. Observational studies indicate that AD patients have reduced microbiome diversity, which could contribute to the pathogenesis of the disease. Uncovering the genetic basis of microbial abundance and its effect on AD could suggest lifestyle changes that may reduce an individual's risk for the disease. Using the largest genome-wide association study of gut microbiota genera from the MiBioGen consortium, we used polygenic risk score (PRS) analyses with the "best-fit" model implemented in PRSice-2 and determined the genetic correlation between 119 genera and AD in a discovery sample (ADc12 case/control: 1278/1293). To confirm the results from the discovery sample, we next repeated the PRS analysis in a replication sample (GenADA case/control: 799/778) and then performed a meta-analysis with the PRS results from both samples. Finally, we conducted a linear regression analysis to assess the correlation between the PRSs for the significant genera and the APOE genotypes. In the discovery sample, 20 gut microbiota genera were initially identified as genetically associated with AD case/control status. Of these 20, three genera (Eubacterium fissicatena as a protective factor, Collinsella, and Veillonella as a risk factor) were independently significant in the replication sample. Meta-analysis with discovery and replication samples confirmed that ten genera had a significant correlation with AD, four of which were significantly associated with the APOE rs429358 risk allele in a direction consistent with their protective/risk designation in AD association. Notably, the proinflammatory genus Collinsella, identified as a risk factor for AD, was positively correlated with the APOE rs429358 risk allele in both samples. Overall, the host genetic factors influencing the abundance of ten genera are significantly associated with AD, suggesting that these genera may serve as biomarkers and targets for AD treatment and intervention. Our results highlight that proinflammatory gut microbiota might promote AD development through interaction with APOE. Larger datasets and functional studies are required to understand their causal relationships.

263. Acetovanillone augmented the cardioprotective effect of carvedilol against cadmium-induced heart injury via suppression of oxidative stress and inflammation signaling pathways.

Sci Rep

2023 Mar 31

Hassanein EHM, Bakr AG, El-Shoura EAM

264. Modulation of cytotoxic amyloid fibrillation and mitochondrial damage of α-synuclein by catechols mediated conformational changes.

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2023 Mar 31

Zohoorian-Abootorabi T, Meratan AA, Jafarkhani S

265. Preoperative neutrophil-to-lymphocyte ratio correlates with PD-L1 expression in immune cells of patients with malignant pleural mesothelioma and predicts prognosis.

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2023 Mar 31

Okita R, Kawamoto N, Okada M

266. Identification and characterization of novel ETV4 splice variants in prostate cancer.

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2023 Mar 31

Cosi I, Moccia A, Pescucci C

267. Using deep learning to predict ideology from facial photographs: expressions, beauty, and extra-facial information.

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2023 Mar 31

Rasmussen SHR, Ludeke SG, Klemmensen R.

268. Person-centered and measured life's simple 7 cardiovascular health concordance and association with incident cardiovascular disease.

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2023 Mar 31

Deraz O, Van Sloten T, Climie R

269. The oldest case of paedomorphosis in rove beetles and description of a new genus of Paederinae from Cretaceous amber (Coleoptera: Staphylinidae).

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2023 Mar 31

Tokareva A, Koszela K, Ferreira VS

270. The COVID-19 vaccination decision-making preferences of elderly people: a discrete choice experiment.

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2023 Mar 31

Chen Y, Wang J, Yi M

271. Evaluation of Mycobacterium tuberculosis enrichment in metagenomic samples using ONT adaptive sequencing and amplicon sequencing for identification and variant calling.

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2023 Mar 31

Su J(#), Lui WW(#), Lee Y(#)

272. An ultra-high-throughput screen for the evaluation of peptide HLA-Binder interactions.

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2023 Mar 31

Krämer S(#), Moritz A(#), Stehl L

273. Alpha-linolenic acid modulates systemic and adipose tissue-specific insulin sensitivity, inflammation, and the endocannabinoid system in dairy cows.

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2023 Mar 31

Kra G(#), Daddam JR(#), Moallem U

274. Elevated number and density of macrophage-like cell as a novel inflammation biomarker in diabetic macular edema.

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2023 Mar 31

Wang Z(#), An H(#), Tang J

275. Three types of bidirectional leader development in triggered lightning flashes.

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2023 Mar 31

Su R(#), Wang F(#), Wang J

276. Mathematical analysis and molecular descriptors of two novel metal-organic models with chemical applications.

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2023 Mar 31

Zaman S, Jalani M, Ullah A

277. Contrasting environmental conditions precluded lower availability of Antarctic krill affecting breeding chinstrap penguins in the Antarctic Peninsula.

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2023 Mar 31

Salmerón N, Belle S, Cruz FS

278. Diagnostic efficacy of cystatin-c in association with different ACE genes predicting renal insufficiency in T2DM.

Sci Rep

2023 Mar 31

Taha MM, Mahdy-Abdallah H, Shahy EM

279. Charge-optimized many-body interaction potential for AlN revisited to explore plasma-surface interactions.

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2023 Mar 31

Gergs T, Mussenbrock T, Trieschmann J.

280. Gene loss during a transition to multicellularity.

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2023 Mar 31

Jiménez-Marín B, Rakijas JB, Tyagi A

281. A novel form stable phase change material with comb-like cross-linked polyurethane as supporting skeleton.

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2023 Mar 31

Yang Y, Xiong S, Fu J

282. Experimental and computational investigation on the charge storage performance of a novel Al(2)O(3)-reduced graphene oxide hybrid electrode.

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2023 Mar 31

Ratha S(#), Sahoo S(#), Mane P

283. Versatile magnetic configuration for the control and manipulation of superparamagnetic nanoparticles.

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2023 Mar 31

Surpi A(#), Shelyakova T(#), Murgia M

284. Impact of dry-off and lyophilized Aloe arborescens supplementation on plasma metabolome of dairy cows.

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2023 Mar 31

Cattaneo L, Rocchetti G, Piccioli-Cappelli F

285. Twin-pulse seeding enables pump-probe capabilities in the EUV to soft X-ray spectrum at synchrotron light sources.

Sci Rep

2023 Mar 31

Yang X, Penn G, Yu LH

Having previously reported that separating the two stages of echo-enabled harmonic generation (EEHG) with one or more bending magnet (BM) sections allows the BMs to serve as the desired source of momentum compaction, here we demonstrate that this arrangement can greatly reduce the total energy modulation required by any 4th generation synchrotron light source, leading to higher repetition rates as well as stronger coherent radiation output power, with significant benefits. Since the EEHG beamline performance is mainly determined by the momentum compaction, beam emittances and beta functions of a storage ring lattice, allowing for different separations between the two stages is a straightforward way to increase the momentum compaction of chicane 1. This also enables pump-probe capabilities in a novel context, where twin-pulse seeding on the same electron bunch would allow two distinct radiation pulses with an adjustable delay in the range of 0.1 to 10 ps. In the twin-pulse seeding scheme, the same electron bunch could undergo modulation from two distinct laser pulses. Later stages would produce independent harmonics in subsequent straight sections. There are two variations of this twin-pulse seeding scheme, supporting different scientific applications. With a common modulation in stage 1, the first option allows simultaneously two independent radiation sources, with a full coverage of the EUV (2.5 to 50 nm) to soft X-ray (1.25 to 2.5 nm) spectrum; for the second option, the same stage 2 undulator could generate two coherent pulses both fitting within the FEL bandwidth, or at distinct harmonics. We present particle tracking simulation studies based on the APS-U lattice, including quantum excitation and radiation damping. These simulations indicate that there is no degradation of the modulated longitudinal phase space even when the two stages are separated by as many as 10 BM sections.

286. A supervised diagnostic experiment of resistance variable multifault locations in a mine ventilation system.

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2023 Mar 31

Wang D, Liu J, Lijun D

287. Study on the influence of shot peening strengthening before shot peen forming on 2024-T351 aluminum alloy fatigue crack growth rate.

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2023 Mar 31

Li G, Dong Z, Luo T

288. Hierarchical cloud architecture for identifying the bite of "Egyptian cobra" based on deep learning and quantum particle swarm optimization.

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2023 Mar 31

Hassan A, Elhoseny M, Kayed M.

289. Immunization of broiler chickens with five newly identified surface-exposed proteins unique to Clostridium perfringens causing necrotic enteritis.

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2023 Mar 31

Heidarpanah S, Thibodeau A, Parreira VR

290. Suicidal risk associated with finasteride versus dutasteride among men treated for benign prostatic hyperplasia: nationwide cohort study.

Sci Rep

2023 Mar 31

Laanani M, Weill A, Jollant F

Finasteride, a 5α-reductase inhibitor used in benign prostatic hyperplasia and androgenetic alopecia, has been associated with an increased suicidal risk, whereas it is unclear whether such risk is similar to that for another 5α-reductase inhibitor, dutasteride. We aimed to assess the risk of suicidal behaviours with finasteride relative to dutasteride. A nationwide cohort study was conducted using the French National Health Data System (SNDS). Men aged 50 years or older initiating finasteride 5 mg or dutasteride 0.5 mg in France between 01-01-2012 and 30-06-2016 were included and followed until outcome (suicide death identified from death certificate or self-harm hospitalisation), treatment discontinuation or switch, death, or 31-12-2016. Self-harm by violent means or resulting in admission to an intensive care unit were also examined. Cox proportional hazards models controlled for age and psychiatric and non-psychiatric conditions by inverse probability of treatment weighting (IPTW). Analyses were stratified according to psychiatric history. The study compared 69,786 finasteride new users to 217,577 dutasteride new users (median age: 72.0 years [Q1-Q3 = 64.5-80.2] vs. 71.1 [Q1-Q3 = 65.0-79.2]). During follow-up, 18 suicide deaths (0.57/1000 person-years) and 34 self-harm hospitalisations (1.08/1000) occurred among finasteride users versus 47 deaths (0.43/1000) and 87 hospitalisations (0.79/1000) among dutasteride users. Overall, finasteride was not associated with an increased risk of any suicidal outcome (IPTW-adjusted Hazard Ratio = 1.21 [95% Confidence Interval .87-1.67]), suicide death or self-harm hospitalisation. However, among individuals with a history of mood disorders, finasteride was associated with an increased risk of any suicidal outcome (25 versus 46 events; HR = 1.64 [95% CI 1.00-2.68]), suicide death (8 versus 10 events; HR = 2.71 [95% CI 1.07-6.91]), self-harm by violent means (6 versus 6 events; HR = 3.11 [95% CI 1.01-9.61]), and self-harm with admission to an intensive care unit (7 versus 5 events; HR = 3.97 [95% CI 1.26-12.5]). None of these risks was significantly increased among individuals without a psychiatric history. These findings do not support an increased risk of suicide with finasteride used in the treatment of benign prostatic hyperplasia. However, an increased risk cannot be excluded among men with a history of mood disorder, but this result based on a limited number of events should be interpreted with caution.

291. Mechanical, microstructural and fracture studies on inconel 825-SS316L functionally graded wall fabricated by wire arc additive manufacturing.

Sci Rep

2023 Mar 31

Senthil TS, Babu SR, Puviyarasan M.

292. L-cysteine/MoS(2) modified robust surface plasmon resonance optical fiber sensor for sensing of Ferritin and IgG.

Sci Rep

2023 Mar 31

Thawany P, Khanna A, Tiwari UK

293. A randomized clinical trial for comparing the efficacy of desensitizing toothpastes on the relief of dentin hypersensitivity.

Sci Rep

2023 Mar 31

Jang JH, Oh S, Kim HJ

294. Substantially elevated serum glutamate and CSF GOT-1 levels associated with cerebral ischemia and poor neurological outcomes in subarachnoid hemorrhage patients.

Sci Rep

2023 Mar 31

Snider S(#), Albano L(#), Gagliardi F

295. Deep sequencing of microRNAs reveals circadian-dependent microRNA expression in the eyestalks of the Chinese mitten crab Eriocheir sinensis.

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2023 Mar 31

Yu C, Huang Z, Xu Y

296. Genetic insights into the causal relationship between physical activity and cognitive functioning.

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2023 Mar 31

Cheval B(#), Darrous L(#), Choi KW

297. Identification of osteosarcoma m6A-related prognostic biomarkers using artificial intelligence: RBM15.

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2023 Mar 31

Jiang J, Qu H, Zhan X

Osteosarcoma has the worst prognosis among malignant bone tumors, and effective biomarkers are lacking. Our study aims to explore m6A-related and immune-related biomarkers. Gene expression profiles of osteosarcoma and healthy controls were downloaded from multiple public databases, and their m6A-based gene expression was utilized for tumor typing using bioinformatics. Subsequently, a prognostic model for osteosarcoma was constructed using the least absolute shrinkage and selection operator and multivariate Cox regression analysis, and its immune cell composition was calculated using the CIBERSORTx algorithm. We also performed drug sensitivity analysis for these two genes. Finally, analysis was validated using immunohistochemistry. We also examined the RBM15 gene by qRT-PCR in an in vitro experiment. We collected routine blood data from 1738 patients diagnosed with osteosarcoma and 24,344 non-osteosarcoma patients and used two independent sample t tests to verify the accuracy of the CIBERSORTx analysis for immune cell differences. The analysis based on m6A gene expression tumor typing was most reliable using the two typing methods. The prognostic model based on the two genes constituting RNA-binding motif protein 15 (RBM15) and YTDC1 had a much lower survival rate for patients in the high-risk group than those in the low-risk group (P < 0.05). CIBERSORTx immune cell component analysis demonstrated that RBM15 showed a negative and positive correlation with T cells gamma delta and activated natural killer cells, respectively. Drug sensitivity analysis showed that these two genes showed varying degrees of correlation with multiple drugs. The results of immunohistochemistry revealed that the expression of these two genes was significantly higher in osteosarcoma than in paraneoplastic tissues. The results of qRT-PCR experiments showed that the expression of RBM15 was significantly higher in both osteosarcomas than in the control cell lines. Absolute lymphocyte value, lymphocyte percentage, hematocrit and erythrocyte count were lower in osteosarcoma than in the control group (P < 0.001). RBM15 and YTHDC1 can serve as potential prognostic biomarkers associated with m6A in osteosarcoma.

298. Development of neutrosophic cubic hesitant fuzzy exponential aggregation operators with application in environmental protection problems.

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2023 Mar 31

Rehman AU, Gulistan M, Ali M

299. Phylogenetic and functional characterization of water bears (Tardigrada) tubulins.

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2023 Mar 30

Novotná Floriančičová K(#), Baltzis A(#), Smejkal J

300. Enhanced mitochondrial oxidative metabolism in peripheral blood mononuclear cells is associated with fatty liver in obese young adults.

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2023 Mar 30

Shirakawa R, Nakajima T, Yoshimura A

301. Materials swelling revealed through automated semantic segmentation of cavities in electron microscopy images.

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2023 Mar 30

Jacobs R, Patki P, Lynch MJ

302. Process development for an effective COVID-19 vaccine candidate harboring recombinant SARS-CoV-2 delta plus receptor binding domain produced by Pichia pastoris.

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2023 Mar 30

Kalyoncu S, Yilmaz S, Kuyucu AZ

303. A double-spiral maze and hi-resolution tracking pipeline to study dispersal by groups of minute insects.

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2023 Mar 30

Cointe M, Burte V, Perez G

304. A retrospective study of differences in patients' anxiety and satisfaction between paper-based and computer-based tools for "Shared Decision-Making".

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2023 Mar 30

Chen JC, Tsai SF, Liu SA.

305. The role of emotional awareness in evaluative judgment: evidence from alexithymia.

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2023 Mar 30

Díaz R, Prinz J.

306. Transverse and longitudinal right ventricular fractional parameters derived from four-chamber cine MRI are associated with right ventricular dysfunction etiology.

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2023 Mar 30

Sato M, Kato T, Ito M

307. Assessing the utility of a sliding-windows deep neural network approach for risk prediction of trauma patients.

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2023 Mar 30

Bonde A, Bonde M, Troelsen A

308. Design and synthesis of strong root gravitropism inhibitors with no concomitant growth inhibition.

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2023 Mar 30

Nishimura T, Makigawa S, Sun J

309. Cardiometabolic function in retired night shift workers and retired day workers.

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2023 Mar 30

Chin BN, Lehrer HM, Tracy EL

310. Evaluation of plasma levels of NFL, GFAP, UCHL1 and tau as Parkinson's disease biomarkers using multiplexed single molecule counting.

Sci Rep

2023 Mar 30

Youssef P, Hughes L, Kim WS

Objective biomarkers for Parkinson's Disease (PD) could aid early and specific diagnosis, effective monitoring of disease progression, and improved design and interpretation of clinical trials. Although alpha-synuclein remains a biomarker candidate of interest, the multifactorial and heterogenous nature of PD highlights the need for a PD biomarker panel. Ideal biomarker candidates include markers that are detectable in easily accessible samples, (ideally blood) and that reflect the underlying pathological process of PD. In the present study, we explored the diagnostic and prognostic PD biomarker potential of the SIMOA neurology 4-plex-A biomarker panel, which included neurofilament light (NFL), glial fibrillary acid protein (GFAP), tau and ubiquitin C-terminal hydrolase L1 (UCHL-1). We initially performed a serum vs plasma comparative study to determine the most suitable blood-based matrix for the measurement of these proteins in a multiplexed assay. The levels of NFL and GFAP in plasma and serum were highly correlated (Spearman rho-0.923, p < 0.0001 and rho = 0.825, p < 0.001 respectively). In contrast, the levels of tau were significantly higher in plasma compared to serum samples (p < 0.0001) with no correlation between sample type (Spearman p > 0.05). The neurology 4-plex-A panel, along with plasma alpha-synuclein was then assessed in a cross-sectional cohort of 29 PD patients and 30 controls. Plasma NFL levels positively correlated with both GFAP and alpha-synuclein levels (rho = 0.721, p < 0.0001 and rho = 0.390, p < 0.05 respectively). As diagnostic biomarkers, the control and PD groups did not differ in their mean NFL, GFAP, tau or UCHL-1 plasma levels (t test p > 0.05). As disease state biomarkers, motor severity (MDS-UPDRS III) correlated with increased NFL (rho = 0.646, p < 0.0001), GFAP (rho = 0.450, p < 0.05) and alpha-synuclein levels (rho = 0.406, p < 0.05), while motor stage (Hoehn and Yahr) correlated with increased NFL (rho = 0.455, p < 0.05) and GFAP (rho = 0.549, p < 0.01) but not alpha-synuclein levels (p > 0.05). In conclusion, plasma was determined to be most suitable blood-based matrix for multiplexing the neurology 4-plex-A panel. Given their correlation with motor features of PD, NFL and GFAP appear to be promising disease state biomarker candidates and further longitudinal validation of these two proteins as blood-based biomarkers for PD progression is warranted.

311. Hybrid high-concentration photovoltaic system designed for different weather conditions.

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2023 Mar 30

Sun C, Wu CS, Lin YS

312. A novel characterisation protocol of mechanical interactions between the ground and a tibial prosthesis for long jump.

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2023 Mar 30

Doyen É, Szmytka F, Semblat JF.

313. Unusual nonlinear switching in branched carbon nanotube nanocomposites.

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2023 Mar 30

Lacarbonara W, Guruva SK, Carboni B

314. Alternative culture medium design for biomass production of autochthonous meat starter Latilactobacillus sakei sp. sakei ACU-2.

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2023 Mar 30

Galante N, Palavecino Prpich N, Campos C

315. Dynamics of non-household contacts during the COVID-19 pandemic in 2020 and 2021 in the Netherlands.

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2023 Mar 30

Backer JA, Bogaardt L, Beutels P

316. Age and market capitalization drive large price variations of cryptocurrencies.

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2023 Mar 30

Pessa AAB, Perc M, Ribeiro HV.

317. Effects of histone methylation modification on low temperature seed germination and growth of maize.

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2023 Mar 30

Qi X(#), Wan C(#), Zhang X

318. Traceability and comparability through crosswalks with the NeuroMET Memory Metric.

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2023 Mar 30

Melin J, Cano SJ, Gillman A

Accurate assessment of memory ability for persons on the continuum of Alzheimer's disease (AD) is vital for early diagnosis, monitoring of disease progression and evaluation of new therapies. However, currently available neuropsychological tests suffer from a lack of standardization and metrological quality assurance. Improved metrics of memory can be created by carefully combining selected items from legacy short-term memory tests, whilst at the same time retaining validity, and reducing patient burden. In psychometrics, this is known as "crosswalks" to link items empirically. The aim of this paper is to link items from different types of memory tests. Memory test data were collected from the European EMPIR NeuroMET and the SmartAge studies recruited at Charité Hospital (Healthy controls n = 92; Subjective cognitive decline n = 160; Mild cognitive impairment n = 50; and AD n = 58; age range 55-87). A bank of items (n = 57) was developed based on legacy short-term memory items (i.e., Corsi Block Test, Digit Span Test, Rey's Auditory Verbal Learning Test, Word Learning Lists from the CERAD test battery and Mini Mental State Examination; MMSE). The NeuroMET Memory Metric (NMM) is a composite metric that comprises 57 dichotomous items (right/wrong). We previously reported on a preliminary item bank to assess memory based on immediate recall, and have now demonstrated direct comparability of measurements generated from the different legacy tests. We created crosswalks between the NMM and the legacy tests and between the NMM and the full MMSE using Rasch analysis (RUMM2030) and produced two conversion tables. Measurement uncertainties for estimates of person memory ability with the NMM across the full span were smaller than all individual legacy tests, which demonstrates the added value of the NMM. Comparisons with one (MMSE) of the legacy tests showed however higher measurement uncertainties of the NMM for people with a very low memory ability (raw score ≤ 19). The conversion tables developed through crosswalks in this paper provide clinicians and researchers with a practical tool to: (i) compensate for ordinality in raw scores, (ii) ensure traceability to make reliable and valid comparisons when measuring person ability, and (iii) enable comparability between test results from different legacy tests.

319. Development and validation of machine learning-based clinical decision support tool for identifying malnutrition in NICU patients.

Sci Rep

2023 Mar 30

Yalçın N, Kaşıkcı M, Çelik HT

320. Hyperpolarized δ-[1- (13)C]gluconolactone imaging visualizes response to TERT or GABPB1 targeting therapy for glioblastoma.

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2023 Mar 30

Minami N(#), Hong D(#), Taglang C

321. A data-driven investigation of human action representations.

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2023 Mar 30

Dima DC, Hebart MN, Isik L.

322. Medial prefrontal cortex oxytocin mitigates epilepsy and cognitive impairments induced by traumatic brain injury through reducing neuroinflammation in mice.

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2023 Mar 30

Chen W, Man X, Zhang Y

323. Psychological distress and its associated factors among patients with chronic obstructive pulmonary disease in Hunan, China: a cross-sectional study.

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2023 Mar 30

Wang C, Yan J, Ma C.

Patients with chronic obstructive pulmonary disease (COPD) experience a high risk for psychological distress. Understanding what factors contributing to this risk is vital for developing effective interventions to address COPD-related psychological distress. To examine psychological distress and its associated factors in COPD patients in China. This is a cross-sectional study. Using cluster random sampling, 351 COPD patients participated in and completed a questionnaire survey from June 2021 to January 2022. Instruments used in this research included a self-designed social-demographic questionnaire, the Kessler Psychological Distress Scale (K10), the COPD Knowledge Question, the Type D Personality Scale (DS-14), the COPD Assessment Test (CAT), and modified Medical Research Council Dyspnea Score (mMRC). Multivariate linear regressions were used in the final analysis. Among 351 COPD patients, 307 (or 87.5%) had psychological distress. Our univariate analysis indicated that psychological distress scores were significantly associated with monthly household income (F = 2.861, P < 0.05), exercise frequency (F = 4.039, P < 0.01), type D personality (t = 5.843, P < 0.01), years with COPD (rs = 0.156, P < 0.01), frequency of acute exacerbation (rs = 0.114, P < 0.05), mMRC score (rs = 0.301, P < 0.01), and CAT score (rs = 0.415, P < 0.01). Our final multivariate linear regression showed that exercise frequency (coefficient = -1.012, P < 0.01) was an independent protective factor of psychological distress in COPD patients, while type D personality (coefficient = 3.463, P < 0.001), mMRC score (coefficient = 1.034, P < 0.001) and CAT score were independent risk factors (coefficient = .288, P < 0.001). No relationship was observed between psychological distress and knowledge of COPD. Psychological distress is commonly presented among COPD patients in China. Findings from this study suggest promoting and increasing frequency of exercise will be beneficial in reducing psychological distress among COPD patients. This study also highlights the importance of assessing personality type, dyspnea, and impact of COPD on daily living for preventing and managing psychological distress due to COPD. In addition, Given the high rate of psychological distress among COPD patients, policymakers should consider making mental health resources easily available and accessible to this vulnerable population.

324. New design for control cage to enhance coverage and uniformity of shot blasting and its validation using DEM and experiment.

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2023 Mar 30

Seo H, Kim T, Yang C

325. New observation of perceptive mechanism behind the long-lasting change of people's community mobility: evidence from COVID-19 in China.

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2023 Mar 30

Ye Z, Yu Y, Liu Y

326. Comparison of concurrent validity of different malnutrition screening tools with the Global Leadership Initiative on Malnutrition (GLIM) among stroke survivors in Malaysia.

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2023 Mar 30

Wong HJ, Harith S, Lua PL

327. Analysis of FCGR3A-p.176Val variants in women with recurrent pregnancy loss and the association with CD16a expression and anti-HLA antibody status.

Sci Rep

2023 Mar 30

Habets DHJ, Al-Nasiry S, Nagelkerke SQ

328. Tapered whisker reservoir computing for real-time terrain identification-based navigation.

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2023 Mar 30

Yu Z, Sadati SMH, Perera S

329. Label-free macrophage phenotype classification using machine learning methods.

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2023 Mar 30

Hourani T, Perez-Gonzalez A, Khoshmanesh K

330. Hazard identification and the prevalence of occupational skin disease in Indonesian Batik workers.

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2023 Mar 30

Febriana SA(#), Ridora Y(#), Indrastuti N

331. When familiarity not novelty motivates information-seeking behaviour.

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2023 Mar 30

Brooks G(#), Whitehead H(#), Kӧhler S.

332. Alkyl chain length of quaternized SBA-15 and solution conditions determine hydrophobic and electrostatic interactions for carbamazepine adsorption.

Sci Rep

2023 Mar 30

Kang JK, Lee H, Kim SB

Santa Barbara Amorphous-15 (SBA) is a stable and mesoporous silica material. Quaternized SBA-15 with alkyl chains (QSBA) exhibits electrostatic attraction for anionic molecules via the N+ moiety of the ammonium group, whereas its alkyl chain length determines its hydrophobic interactions. In this study, QSBA with different alkyl chain lengths were synthesized using the trimethyl, dimethyloctyl, and dimethyoctadecyl groups (C1QSBA, C8QSBA, and C18QSBA, respectively). Carbamazepine (CBZ) is a widely prescribed pharmaceutical compound, but is difficult to remove using conventional water treatments. The CBZ adsorption characteristics of QSBA were examined to determine its adsorption mechanism by changing the alkyl chain length and solution conditions (pH and ionic strength). A longer alkyl chain resulted in slower adsorption (up to 120 min), while the amount of CBZ adsorbed was higher for longer alkyl chains per unit mass of QSBA at equilibrium. The maximum adsorption capacities of C1QSBA, C8QSBA, and C18QSBA, were 3.14, 6.56, and 24.5 mg/g, respectively, as obtained using the Langmuir model. For the tested initial CBZ concentrations (2-100 mg/L), the adsorption capacity increased with increasing alkyl chain length. Because CBZ does not dissociate readily (pKa = 13.9), stable hydrophobic adsorption was observed despite the changes in pH (0.41-0.92, 1.70-2.24, and 7.56-9.10 mg/g for C1QSBA, C8QSBA, and C18QSBA, respectively); the exception was pH 2. Increasing the ionic strength from 0.1 to 100 mM enhanced the adsorption capacity of C18QSBA from 9.27 ± 0.42 to 14.94 ± 0.17 mg/g because the hydrophobic interactions were increased while the electrostatic attraction of the N+ was reduced. Thus, the ionic strength was a stronger control factor determining hydrophobic adsorption of CBZ than the solution pH. Based on the changes in hydrophobicity, which depends on the alkyl chain length, it was possible to enhance CBZ adsorption and investigate the adsorption mechanism in detail. Thus, this study aids the development of adsorbents suitable for pharmaceuticals with controlling molecular structure of QSBA and solution conditions.

333. Diagnostic ability of macular microvasculature with swept-source OCT angiography for highly myopic glaucoma using deep learning.

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2023 Mar 30

Lee YJ, Sun S, Kim YK

334. Compact and automated eDNA sampler for in situ monitoring of marine environments.

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2023 Mar 30

Hendricks A(#), Mackie CM(#), Luy E

335. Evaluation of artificial intelligence model for crowding categorization and extraction diagnosis using intraoral photographs.

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2023 Mar 30

Ryu J, Kim YH, Kim TW(#)

336. Shared mental representations underlie metaphorical sound concepts.

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2023 Mar 30

Rosi V, Arias Sarah P, Houix O

337. High-precision spatial analysis of mouse courtship vocalization behavior reveals sex and strain differences.

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2023 Mar 30

Oliveira-Stahl G(#), Farboud S(#), Sterling ML

338. Association of obesity with incident atrial fibrillation in Korea and the United Kingdom.

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2023 Mar 30

Choi SH(#), Yang PS(#), Kim D

339. Etiological analysis of patients with sudden sensorineural hearing loss: a prospective case-control study.

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2023 Mar 30

Xie W, Karpeta N, Tong B

340. Weakly supervised label propagation algorithm classifies lung cancer imaging subtypes.

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2023 Mar 30

Ren X, Jia L, Zhao Z

341. Experimental study on the galloping characteristics of single ice-coated transmission lines under oblique flows.

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2023 Mar 30

Gao M, Chen Z, Su J

342. Results of a phase Ib study of SB-121, an investigational probiotic formulation, a randomized controlled trial in participants with autism spectrum disorder.

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2023 Mar 30

Schmitt LM, Smith EG, Pedapati EV

Autism Spectrum Disorder (ASD) is a neurodevelopmental disorder characterized by core impairments in social communication as well as restricted, repetitive patterns of behavior and/or interests. Individuals with ASD, which includes about 2% of the US population, have challenges with activities of daily living and suffer from comorbid medical and mental health concerns. There are no drugs indicated for the core impairments of ASD. As such, there is a significant need for the development of new medication strategies for individuals with ASD. This first-in-human placebo-controlled, double-blind, crossover study investigated the safety (primary objective) and efficacy of oral SB-121, a combination of L. reuteri, Sephadex® (dextran microparticles), and maltose administered once daily for 28 days in 15 autistic participants. SB-121 was safe and well tolerated. SB-121-associated directional improvements in adaptive behavior measured by Vineland-3 and social preference as measured with eye tracking were noted. These results provide support for further clinical evaluation of SB-121 as a treatment in autistic patients. To evaluate the safety and tolerability of multiple doses of SB-121 in subjects with autism spectrum disorder. Single-center, randomized, placebo-controlled, double-blind, crossover trial. 15 patients with autism spectrum disorder were randomized and analyzed. Daily dosing of SB-121 or placebo for 28 days, followed by approximately a 14 day washout, then 28 days of dosing with other treatment. Incidence and severity of adverse events, presence of Limosilactobacillus reuteri and Sephadex® in stool, and incidence of bacteremia with positive L. reuteri identification. Additional outcomes include changes from baseline on cognitive and behavior tests as well as biomarker levels. Adverse event rates were similar between SB-121 and placebo, with most reported as mild. There were no severe or serious adverse events. No participants had features of suspected bacteremia or notable changes in vital signs, safety laboratory, or ECG parameters from baseline. There was a statistically significant increase from baseline in the Vineland-3 Adaptive Behavior Composite score (p = 0.03) during SB-121 treatment. There was a trend for increased social/geometric viewing ratio following SB-121 treatment compared to placebo. SB-121 was safe and well tolerated. SB-121-associated directional improvements in adaptive behavior measured by Vineland-3 and social preference as measured with eye tracking were noted.Trial registration: clinicaltrials.gov Identifier: NCT04944901.

343. Collective dynamics of dense hairy surfaces in turbulent flow.

Sci Rep

2023 Mar 30

Monti A(#), Olivieri S(#), Rosti ME.

344. Silver-assisted reduction of nitroarenes by an Ag-embedded curcumin/melamine-functionalized magnetic nanocatalyst.

Sci Rep

2023 Mar 30

Khaleghi N, Forouzandeh-Malati M, Ganjali F

345. Synchronized proinsulin trafficking reveals delayed Golgi export accompanies β-cell secretory dysfunction in rodent models of hyperglycemia.

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2023 Mar 30

Boyer CK, Bauchle CJ, Zhang J

346. ABCB1 expression is increased in human first trimester placenta from pregnant women classified as overweight or obese.

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2023 Mar 30

Justesen S(#), Bilde K(#), Olesen RH

Obesity has become a global health challenge also affecting reproductive health. In pregnant women, obesity increases the risk of complications such as preterm birth, macrosomia, gestational diabetes, and preeclampsia. Moreover, obesity is associated with long-term adverse effects for the offspring, including increased risk of cardiovascular and metabolic diseases and neurodevelopmental difficulties. The underlying mechanisms are far from understood, but placental function is essential for pregnancy outcome. Transporter proteins P-glycoprotein (P-gp) and Breast Cancer Resistance Protein (BCRP) are important for trans-placental transport of endogenous substances like lipids and cortisol, a key hormone in tissue maturation. They also hold a protective function protecting the fetus from xenobiotics (e.g. pharmaceuticals). Animal studies suggest that maternal nutritional status can affect expression of placental transporters, but little is known about the effect on the human placenta, especially in early pregnancy. Here, we investigated if overweight and obesity in pregnant women altered mRNA expression of ABCB1 encoding P-gp or ABCG2 encoding BCRP in first trimester human placenta. With informed consent, 75 first trimester placental samples were obtained from women voluntarily seeking surgical abortion (< gestational week 12) (approval no.: 20060063). Villous samples (average gestational age 9.35 weeks) were used for qPCR analysis. For a subset (n = 38), additional villi were snap-frozen for protein analysis. Maternal BMI was defined at the time of termination of pregnancy. Compared to women with BMI 18.5-24.9 kg/m2 (n = 34), ABCB1 mRNA expression was significantly increased in placenta samples from women classified as overweight (BMI 25-29.9 kg/m2, n = 18) (p = 0.040) and women classified as obese (BMI ≥ 30 kg/m2, n = 23) (p = 0.003). Albeit P-gp expression did not show statistically significant difference between groups, the effect of increasing BMI was the same in male and female pregnancies. To investigate if the P-gp increase was compensated, we determined the expression of ABCG2 which was unaffected by maternal obesity (p = 0.291). Maternal BMI affects ABCB1 but not ABCG2 mRNA expression in first trimester human placenta. Further studies of early placental function are needed to understand how the expression of placental transport proteins is regulated by maternal factors such as nutritional status and determine the potential consequences for placental-fetal interaction.

347. Effect of hetero-atom doping on the electrocatalytic properties of graphene quantum dots for oxygen reduction reaction.

Sci Rep

2023 Mar 30

Goswami M, Mandal S, Pillai VK.

348. The temporal cost of deploying attention limits accurate target identification in rapid serial visual presentation.

Sci Rep

2023 Mar 3

Kimata AR, Zheng B, Watanabe T

349. Association of ApaI rs7975232 and BsmI rs1544410 in clinical outcomes of COVID-19 patients according to different SARS-CoV-2 variants.

Sci Rep

2023 Mar 3

Al-Gharrawi ANR, Anvari E, Fateh A.

350. Incidence and predictors of severe postpartum hemorrhage after cesarean delivery in South Central Ethiopia: a retrospective cohort study.

Sci Rep

2023 Mar 3

Zewdu D, Tantu T.

351. Strata temperatures and geothermal resource evaluation in the Dongpu Depression, Bohai Bay Basin, North China.

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2023 Mar 3

Qiao Y, Zuo Y, Tu S

352. Effects of additive interactions among obesity, visceral adiposity, and sarcopenia on nonalcoholic fatty liver disease.

Sci Rep

2023 Mar 3

Chung GE(#), Oh S(#), Ahn DW

353. Evaluation of the second-generation whole-heart motion correction algorithm (SSF2) used to demonstrate the aortic annulus on cardiac CT.

Sci Rep

2023 Mar 3

Matsumoto Y, Fujioka C, Yokomachi K

354. Consecutive multiscale feature learning-based image classification model.

Sci Rep

2023 Mar 3

Olimov B, Subramanian B, Ugli RAA

355. Significance of pulse pressure variability in predicting functional outcome in acute ischemic stroke: a retrospective, single-center, observational cohort study.

Sci Rep

2023 Mar 3

Kamieniarz-Mędrygał M, Kaźmierski R.

356. On an effective and efficient method for exploiting the wisdom of the inner crowd.

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2023 Mar 3

Fujisaki I, Yang K, Ueda K.

357. Enhanced electrocatalytic activity of Pt-SnO(2) nanoparticles supported on natural bentonite-functionalized reduced graphene oxide-extracted chitosan from shrimp wastes for methanol electro-oxidation.

Sci Rep

2023 Mar 3

Aryafar A, Ekrami-Kakhki MS, Naeimi A.

358. Iodine maps derived from sparse-view kV-switching dual-energy CT equipped with a deep learning reconstruction for diagnosis of hepatocellular carcinoma.

Sci Rep

2023 Mar 3

Narita K, Nakamura Y, Higaki T

Deep learning-based spectral CT imaging (DL-SCTI) is a novel type of fast kilovolt-switching dual-energy CT equipped with a cascaded deep-learning reconstruction which completes the views missing in the sinogram space and improves the image quality in the image space because it uses deep convolutional neural networks trained on fully sampled dual-energy data acquired via dual kV rotations. We investigated the clinical utility of iodine maps generated from DL-SCTI scans for assessing hepatocellular carcinoma (HCC). In the clinical study, dynamic DL-SCTI scans (tube voltage 135 and 80 kV) were acquired in 52 patients with hypervascular HCCs whose vascularity was confirmed by CT during hepatic arteriography. Virtual monochromatic 70 keV images served as the reference images. Iodine maps were reconstructed using three-material decomposition (fat, healthy liver tissue, iodine). A radiologist calculated the contrast-to-noise ratio (CNR) during the hepatic arterial phase (CNRa) and the equilibrium phase (CNRe). In the phantom study, DL-SCTI scans (tube voltage 135 and 80 kV) were acquired to assess the accuracy of iodine maps; the iodine concentration was known. The CNRa was significantly higher on the iodine maps than on 70 keV images (p < 0.01). The CNRe was significantly higher on 70 keV images than on iodine maps (p < 0.01). The estimated iodine concentration derived from DL-SCTI scans in the phantom study was highly correlated with the known iodine concentration. It was underestimated in small-diameter modules and in large-diameter modules with an iodine concentration of less than 2.0 mgI/ml. Iodine maps generated from DL-SCTI scans can improve the CNR for HCCs during hepatic arterial phase but not during equilibrium phase in comparison with virtual monochromatic 70 keV images. Also, when the lesion is small or the iodine concentration is low, iodine quantification may result in underestimation.

359. Fluorescence Lifetime Imaging Microscopy (FLIM) reveals spatial-metabolic changes in 3D breast cancer spheroids.

Sci Rep

2023 Mar 3

Karrobi K(#), Tank A(#), Fuzail MA

360. Successful induction of pseudopregnancy using sonic vibration in mice.

Sci Rep

2023 Mar 3

Wake Y, Endo M, Tsunoda S

361. Comparison between strip sampling and laser ablation methods to infer seasonal movements from intra-tooth strontium isotopes profiles in migratory caribou.

Sci Rep

2023 Mar 3

Le Corre M, Grimes V, Lam R

362. Primary ILM peeling during retinal detachment repair: a systematic review and meta-analysis.

Sci Rep

2023 Mar 3

Lamas-Francis D, Bande-Rodríguez M, Blanco-Teijeiro MJ.

363. Genomic characteristics and clinical significance of CD56+ circulating tumor cells in small cell lung cancer.

Sci Rep

2023 Mar 3

Ricordel C(#), Chaillot L(#), Vlachavas EI(#)

364. Feature augmentation based on information fusion rectification for few-shot image classification.

Sci Rep

2023 Mar 3

Wang H, Tian S, Fu Y

365. Effect of exercise training with laser phototherapy on homeostasis balance resistant to hypercoagulability in seniors with obesity: a randomized trial.

Sci Rep

2023 Mar 3

Elsayed MM, Abdallah GA, Hassan SS

366. Machine learning identifies straightforward early warning rules for human Puumala hantavirus outbreaks.

Sci Rep

2023 Mar 3

Kazasidis O, Jacob J.

367. Living in human-modified landscapes narrows the dietary niche of a specialised mammalian scavenger.

Sci Rep

2023 Mar 3

Lewis AC, Hughes C, Rogers TL.

368. Label-free photothermal optical coherence microscopy to locate desired regions of interest in multiphoton imaging of volumetric specimens.

Sci Rep

2023 Mar 3

Ravichandran NK, Hur H, Kim H

369. Comparison of clinicopathological and genomic profiles in anal squamous cell carcinoma between Japanese and Caucasian cohorts.

Sci Rep

2023 Mar 3

Ito T(#), Takayanagi D(#), Sekine S

370. A new class A beta-lactamase gene bla(CAE-1) coexists with bla(AFM-1) in a novel untypable plasmid in Comamonas aquatica.

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2023 Mar 3

Li Y, Fang C, Wang X

371. Sand fly population dynamics in areas of American cutaneous leishmaniasis, Municipality of Paraty, Rio de Janeiro, Brazil.

Sci Rep

2023 Mar 3

Vieira VR, de Aguiar GM, de Azevedo ACR

372. Learning curve for open surgical repair of acute type A aortic dissection.

Sci Rep

2023 Mar 3

Hou BC(#), Huang YT(#), Hsiao FC

373. Biofluorescent sexual dimorphism revealed in a southern Appalachian endemic salamander, Plethodon metcalfi.

Sci Rep

2023 Mar 3

Cox JL, Fitzpatrick BM.

374. Increased probability of hot and dry weather extremes during the growing season threatens global crop yields.

Sci Rep

2023 Mar 3

Heino M, Kinnunen P, Anderson W

375. An interpretable transformer network for the retinal disease classification using optical coherence tomography.

Sci Rep

2023 Mar 3

He J, Wang J, Han Z

376. Association between height loss and mortality in the general population.

Sci Rep

2023 Mar 3

Iwasaki T, Kimura H, Tanaka K

377. High-frequency spin torque oscillation in orthogonal magnetization disks with strong biquadratic magnetic coupling.

Sci Rep

2023 Mar 3

Liu C, Kurokawa Y, Hashimoto N

378. An edge communication based probabilistic caching for transient content distribution in vehicular networks.

Sci Rep

2023 Mar 3

Gupta D, Rani S, Tiwari B

379. Technical assessment of different extraction methods and transcriptome profiling of RNA isolated from small volumes of blood.

Sci Rep

2023 Mar 3

Kalikiri MKR(#), Manjunath HS(#), Vempalli FR(#)

380. Intense community dynamics in the pre-Roman frontier site of Fermo (ninth-fifth century BCE, Marche, central Italy) inferred from isotopic data.

Sci Rep

2023 Mar 3

Esposito C, Gigante M, Lugli F

381. Room-temperature bonding of Al(2)O(3) thin films deposited using atomic layer deposition.

Sci Rep

2023 Mar 3

Takakura R, Murakami S, Watanabe K

382. Habitat partitioning, co-occurrence patterns, and mixed-species group formation in sympatric delphinids.

Sci Rep

2023 Mar 3

Syme J, Kiszka JJ, Parra GJ.

383. Determination of orally administered 1,8-Cineol in nasal polyp tissues from chronic rhinosinusitis patients using gas chromatography: mass spectrometry.

Sci Rep

2023 Mar 3

MacKenzie C, Goerke T, Buecking M

384. Risk factors associated with limited functional status among out-of-hospital patients 30 days and one year after a diagnosis of COVID-19: a cohort study.

Sci Rep

2023 Mar 3

Laskovski L, Felcar JM, Fillis MMA

Some people experience indefinitely persistent and disabling symptoms after acute COVID-19, even those who have not been hospitalized. The purpose of this study was to analyze the long-term health consequences at 30 days and one year among people who were not hospitalized after a diagnosis of COVID-19 and to analyze which variables predict limitations in functional status. This is a prospective cohort study with non-hospitalized adults infected with SARS-CoV-2 in the city of Londrina. After 30 days and one year of the acute symptoms of COVID-19, participants received the questionnaire through a social media that consisted of sociodemographic data and data on functionality through the Post-COVID Functional State Scale (PCFS)-the primary outcome of the study "presence of functional status limitation" was grouped into without functional status limitation (value: zero) and with functional limitation (value 1 to 4), fatigue through of the Fatigue Severity Scale (FSS) and dyspnea using the modified Borg scale. In the statistical analysis, multivariable analysis was performed. Statistical significance was set to 5%. Of 140 individuals analyzed, 103 (73.6%) were female with a median age of 35.5 (27-46) years. One year after the diagnosis of COVID-19, 44.3% had at least one self-reported symptom: memory loss (13.6%), gloominess (8.6%), anosmia (7.9%), body pain (7.1%), ageusia (7%), headache (6.4%), and cough (3.6%). According to the FSS and modified Borg scale 42.9% reported fatigue and 18.6% reported dyspnea, respectively. As for functionality, 40.7% reported some limitation, being 24.3% negligible functional limitation, 14.3% slight and 2.1% moderate according to the PCFS. There was a univariate association between the presence of limitation in the functional status with the female sex, diagnosis of anxiety and depression, presence of persistent symptoms after one year, fatigue and dyspnea. In the multivariable analysis, the predictor variables for functional status limitation were female sex, diagnosis of anxiety/depression, presence of at least one persistent symptom and fatigue one year after the diagnosis of COVID-19. One year after the disease, the patients presented functional limitation according to the PCFS, even without hospitalization. Risk factors associated with functional limitation include female sex, presence of fatigue, anxiety and depression, and at least one persistent symptom after one year of COVID-19 diagnosis.

385. Synchrony to a beat predicts synchrony with other minds.

Sci Rep

2023 Mar 3

Wohltjen S, Toth B, Boncz A

386. Synthesis and characterization of calcium and magnesium based oxides and titanates for photocatalytic degradation of rhodamine B: a comparative study.

Sci Rep

2023 Mar 3

Vijayakumar N(#), Venkatraman SK(#), Imthiaz S

387. Establishing the contribution of active histone methylation marks to the aging transcriptional landscape of Drosophila photoreceptors.

Sci Rep

2023 Mar 29

Jauregui-Lozano J, McGovern SE, Bakhle KM

388. Dietary riboflavin intake in relation to psychological disorders in Iranian adults: an observational study.

Sci Rep

2023 Mar 29

Rouhani P(#), Amoushahi M(#), Keshteli AH

389. Magnetic resonance brain volumetry biomarkers of CLN2 Batten disease identified with miniswine model.

Sci Rep

2023 Mar 29

Knoernschild K, Johnson HJ, Schroeder KE

390. Cobalt isatin-Schiff-base derivative of MOF as a heterogeneous multifunctional bio-photocatalyst for sunlight-induced tandem air oxidation condensation process.

Sci Rep

2023 Mar 29

Rouzifar M, Sobhani S, Farrokhi A

391. Interaction analysis of ancestry-enriched variants with APOE-ɛ4 on MCI in the Study of Latinos-Investigation of Neurocognitive Aging.

Sci Rep

2023 Mar 29

Granot-Hershkovitz E, Xia R, Yang Y

392. Optimization of Cd (II) removal from aqueous solution by natural hydroxyapatite/bentonite composite using response surface methodology.

Sci Rep

2023 Mar 29

Desalegn YM, Bekele EA, Olu FE.

393. 2.5D printing of a yield-stress fluid.

Sci Rep

2023 Mar 29

Colanges S, Tourvieille JN, Lidon P

394. Prediction of cognitive decline in Parkinson's disease (PD) patients with electroencephalography (EEG) connectivity characterized by time-between-phase-crossing (TBPC).

Sci Rep

2023 Mar 29

Gschwandtner U, Bogaarts G, Roth V

395. Differences between recreational gamers and Internet Gaming Disorder candidates in a sample of Animal Crossing: New Horizons players.

Sci Rep

2023 Mar 29

Wischert-Zielke M, Barke A.

396. Retinal vessel geometry in patients with idiopathic epiretinal membrane.

Sci Rep

2023 Mar 29

Lee EK, Kim HJ, Lee SY

397. Revisiting the baby schema by a geometric morphometric analysis of infant facial characteristics across great apes.

Sci Rep

2023 Mar 29

Kawaguchi Y, Nakamura K, Tajima T

398. p130Cas is required for androgen-dependent postnatal development regulation of submandibular glands.

Sci Rep

2023 Mar 29

Gao J(#), Li A(#), Fujii S

399. Impact of COVID-19 pandemic on emergency medical system and management strategies in patients with acute coronary syndrome.

Sci Rep

2023 Mar 29

Saiin K(#), Takenaka S(#), Nagai T

400. Free androgen index (FAI)'s relations with oxidative stress and insulin resistance in polycystic ovary syndrome.

Sci Rep

2023 Mar 29

Rahmatnezhad L, Moghaddam-Banaem L, Behrouzi Lak T

401. Superanomalous skin-effect and enhanced absorption of light scattered on conductive media.

Sci Rep

2023 Mar 29

Vagov A, Larkin IA, Croitoru MD

402. Evaporative destabilization of a salt crust with branched pattern formation.

Sci Rep

2023 Mar 29

Licsandru G, Noiriel C, Duru P

403. A proficiency assessment of integrating machine learning (ML) schemes on Lahore water ensemble.

Sci Rep

2023 Mar 29

Shahid N.

A synthesis of statistical inference and machine learning (ML) tools has been employed to establish a comprehensive insight of a coarse data. Water components' data for 16 central distributing locations of Lahore, the capital of second most populated province of Pakistan, has been analyzed to gauge current water stature of the city. Moreover, a classification of surplus-response variables through tolerance manipulation was incorporated to debrief dimension aspect of the data. By the same token, the influence of supererogatory variables' renouncement through identification of clustering movement of constituents is inquired. The approach of building a spectrum of colluding results through application of comparable methods has been experimented. To test the propriety of each statistical method prior to its execution on a huge data, a faction of ML schemes have been proposed. The supervised learning tools pca, factoran and clusterdata were implemented to establish an elemental character of water at elected locations. A location 'LAH-13' was highlighted for containing an out of normal range Total Dissolved Solids (TDS) concentration in the water. The classification of lower and higher variability parameters carried out by Sample Mean (XBAR) control identified a set of least correlated variables pH, As, Total Coliforms and E. Coli. The analysis provided four locations LAH-06, LAH-10, LAH-13 and LAH-14 for extreme concentration propensity. An execution of factoran demonstrated that specific tolerance of independent variability '0.005' could be employed to reduce dimension of a system without loss of fundamental data information. A higher value of cophenetic coefficient, c = 0.9582 provided the validation for an accurate cluster division of similar characteristics' variables. The current approach of mutually validating ML and SA (statistical analysis) schemes will assist in preparing the groundwork for state of the art analysis (SOTA) analysis. The advantage of our approach can be examined through the fact that the related SOTA will further refine the predictive precision between two comparable methods, unlike the SOTA analysis between two random ML methods. Conclusively, this study featured the locations LAH-03, LAH-06, LAH-12, LAH-13, LAH-14 and LAH-15 with compromised water quality in the region.

404. Exploring the potential of late permian aggregate resources for utilization in engineering structures through geotechnical, geochemical and petrographic analyses.

Sci Rep

2023 Mar 29

Hussain J, Zhang J, Iqbal SM

405. Characterization of butyrate-metabolism in colorectal cancer to guide clinical treatment.

Sci Rep

2023 Mar 29

Luo Q, Zhou P, Chang S

Colorectal cancer (CRC) is the third most prevalent one in the world among the most common malignant tumors. Numerous studies have shown that butyrate has demonstrated promise as an antitumor agent in a variety of human cancer types. However, butyrate remains understudied in CRC tumorigenesis and progression. In this study, we explored therapeutic strategies to treat CRC by examining the role of butyrate metabolism. First, from the Molecular Signature Database (MSigDB), we identified 348 butyrate metabolism-related genes (BMRGs). Next, we downloaded 473 CRC and 41 standard colorectal tissue samples from The Cancer Genome Atlas (TCGA) database and the transcriptome data of GSE39582 dataset from Gene Expression Omnibus (GEO) database. Then we evaluated the expression patterns of butyrate metabolism-related genes with difference analysis in CRC. Through univariate Cox regression and least absolute shrinkage and selection operator (LASSO) analysis, a prognostic model was constructed based on differentially expressed BMRGs. In addition, we discovered an independent prognostic marker for CRC patients. According to the expression levels and coefficients of identified BMRGs, the risk scores of all CRC samples were calculated. Utilizing differentially expressed genes in the high- and low-risk groups, we also constructed a Protein-Protein Interaction (PPI) network to visualize the interactions between proteins. Through the results of PPI network, we screened out differentially expressed target butyrate metabolism-related genes from ten hub genes. Finally, we performed clinical correlation analysis, immune cell infiltration analysis, and mutation analysis for these target genes. One hundred and seventy three differentially expressed butyrate metabolism-related genes were screened out in all the CRC samples. The prognostic model was established with univariate Cox regression and LASSO regression analysis. CRC patients' overall survival was significantly lower in the high-risk group than in the low-risk group for both training and validation set. Among the ten hub genes identified from the PPI network, four target butyrate metabolism-related genes were identified containing FN1, SERPINE1, THBS2, and COMP, which might provide novel markers or targets for treating CRC patients. Eighteen butyrate metabolism-related genes were used to develop a risk prognostic model that could be helpful for doctors to predict CRC patients' survival rate. Using this model, it is beneficial to forecast the response of CRC patients to immunotherapy and chemotherapy, thus making it easier to custom tailor cancer chemotherapy and immunotherapy to the individual patient.

406. Charlson comorbidity index applied to shunted idiopathic normal pressure hydrocephalus.

Sci Rep

2023 Mar 29

Klinge PM(#), Ma KL(#), Leary OP

407. Possible contribution of phosphate to the pathogenesis of chronic kidney disease in dolphins.

Sci Rep

2023 Mar 29

Jahan N, Ohsaki H(#), Kaneko K(#)

408. A high-sensitivity rotatable 3D displacement sensor.

Sci Rep

2023 Mar 29

Cai J, Jiang T, Gao Z

409. Risk assessment of human exposure to airborne pesticides in rural greenhouses.

Sci Rep

2023 Mar 29

Hu Y, Wu S, Lyu W

410. The best location for the application of static magnetic fields based on biokinetic coefficients in complete-mix activated sludge process.

Sci Rep

2023 Mar 29

Asgari G, Seid-Mohammadi A, Shokoohi R

411. Efficacy of elotuzumab for multiple myeloma in reference to lymphocyte counts and kappa/lambda ratio or B2 microglobulin.

Sci Rep

2023 Mar 29

Shimazu Y, Kanda J, Kosugi S

412. Comparative genomic analysis of Colistin resistant Escherichia coli isolated from pigs, a human and wastewater on colistin withdrawn pig farm.

Sci Rep

2023 Mar 29

Khine NO, Wongsurawat T, Jenjaroenpun P

413. Abnormalities in intron retention characterize patients with systemic lupus erythematosus.

Sci Rep

2023 Mar 29

Sun X(#), Liu Z(#), Li Z

414. In vitro evaluation of genipin-crosslinked gelatin hydrogels for vocal fold injection.

Sci Rep

2023 Mar 29

Ng WC, Lokanathan Y, Fauzi MB

415. Prokineticin 1 is a novel factor regulating porcine corpus luteum function.

Sci Rep

2023 Mar 29

Baryla M, Goryszewska-Szczurek E, Kaczynski P

416. Association between lipid levels and all-cause and cause-specific mortality in critically ill patients.

Sci Rep

2023 Mar 29

Li S, Zhang W, Liu H.

417. Effect of sizes of vinyl modified narrow-dispersed silica cross-linker on the mechanical properties of acrylamide based hydrogel.

Sci Rep

2023 Mar 29

Karim MR, Harun-Ur-Rashid M, Imran AB.

418. Exploring preferences and decision-making about long-acting injectable HIV pre-exposure prophylaxis (PrEP) among young sexual minority men 17-24 years old.

Sci Rep

2023 Mar 29

John SA, Zapata JP, Dang M

419. Retinal tissue and microvasculature loss in COVID-19 infection.

Sci Rep

2023 Mar 29

Kalaw FGP(#), Warter A(#), Cavichini M

420. Study of the distribution of Glycyrrhiza uralensis production areas as well as the factors affecting yield and quality.

Sci Rep

2023 Mar 29

Cui X, Lou L, Zhang Y

421. Raman spectroscopy combined with a support vector machine algorithm as a diagnostic technique for primary Sjögren's syndrome.

Sci Rep

2023 Mar 29

Chen X(#), Wu X(#), Chen C

422. Sarcopenia as a potential risk factor for senile blepharoptosis: Nationwide Surveys (KNHANES 2008-2011).

Sci Rep

2023 Mar 29

Byeon HJ(#), Kim YJ(#), Yoon JS

423. Mendelian randomization analyses reveal causal relationships between the human microbiome and longevity.

Sci Rep

2023 Mar 29

Liu X(#), Zou L(#), Nie C(#)

424. The dependence of particle size on cell toxicity for modern mining dust.

Sci Rep

2023 Mar 29

Chen YH, Nguyen D, Brindley S

425. Study of the solid-gas-stress coupling model and its application.

Sci Rep

2023 Mar 29

Shi X, Song D.

426. The impact of biosynthesized ZnO nanoparticles from Olea europaea (Common Olive) on Pseudomonas aeruginosa growth and biofilm formation.

Sci Rep

2023 Mar 29

Al-Momani H, Al Balawi D, Hamed S

There is a limitation in the range of effectual antibiotics due to the Pseudomonas aeruginosa (PA) infection due to its innate antimicrobial resistance. Researchers have therefore been concentrating their efforts to discover advanced and cost effective antibacterial agents among the ever-increasing PA bacterial resistance strains. It has been discovered that various nanoparticles can be employed as antimicrobial agents. Here, we evaluated the antibacterial properties of the Zinc Oxide nanoparticles (ZnO NPs), which was biosynthesized, being examined on six hospital strains of PA alongside a reference strain (ATCC 27853). A chemical approach was applied to biosynthesize the ZnO NPs from Olea europaea was performed, and confirmed by using X-ray diffraction and Scanning Electron Microscopes. The nanoparticles then applied their antibacterial properties to examine them against six clinically isolated PA strains alongside the reference strain. This process tested for the results of the minimum inhibitory concentration (MIC) and the minimum bactericidal concentration (MBC). The Growth, biofilm formation and eradication were analyzed. The influence of the differentiating degrees ZnO NPs in regard to Quorom sensing gene expression were further examined. The ZnO NPs exhibited a crystalline size and diameter (Dc) of 40-60 nm and both the MIC and MBC tests revealed positive outcomes of concentrations of 3 and 6 mg/ml for each PA strain, respectively. At sub inhibitory concentration, The ZnO NPs were found to significantly inhibit the growth and biofilm formation of all PA strains and decreases in the biomass and metabolic behavior of PA established biofilms; these decreases varied depending on the dosage. At ZnO NPs concentrations of 900 µg/ml, the expression of majority of quorum sensing genes of all strains were significantly reduced, at ZnO NPs concentrations of 300 µg/ml, few genes were significantly impacted. In conclusion, the treatment of PA and could be other antibiotic resistant bacteria can therefore be approached by using ZnO NPs as it has been uncovered that they withhold advanced antibacterial properties.

427. Modified extended object tracker for 2D lidar data using random matrix model.

Sci Rep

2023 Mar 29

Li P, Chen C, You CZ

428. A glucose tolerant β-glucosidase from a newly isolated Neofusicoccum parvum strain F7: production, purification, and characterization.

Sci Rep

2023 Mar 29

Singh N, Sithole B, Kumar A

429. An immune indicator based on BTK and DPEP2 identifies hot and cold tumors and clinical treatment outcomes in lung adenocarcinoma.

Sci Rep

2023 Mar 29

Han T(#), Liu Y(#), Wu J

In lung adenocarcinoma (LUAD), immune heterogeneity of hot and cold tumors has been recognized as one of the major factors affecting immunotherapy and other common treatments. However, there is still a lack of biomarkers that can effectively identify the immunophenotype of cold and hot tumors. First, the immune signatures were obtained based on literature mining, including macrophage/monocyte, IFN-γ response, TGF-β response, IL12 response, lymphocyte activation, and ECM/Dve/immune response. Subsequently, LUAD patients were further clustered into different immune phenotypes based on these immune signatures. Next, the key genes related to the immune phenotypes were screened by WGCNA analysis, univariate analysis, and lasso-cox analysis, and the risk signature was established via the key genes. In additional, we compared the clinicopathological characteristics, drug sensitivity, the abundance of immune infiltration, and the efficacy of immunotherapy and commonly used therapies between patients in the high- and low-risk groups in LUAD. LUAD patients were divided into immune hot phenotype and immune cold phenotype groups. The clinical presentation showed that patients with the immune hot phenotype had higher immunoactivity (including higher MHC, CYT, immune, stromal, ESTIMATE scores, higher abundance of immune cell infiltration, higher abundance of TIL, and enrichment of immune-enriched subtypes) and better survival outcomes than those with the immune cold phenotype. Subsequently, WGCNA analysis, univariate analysis, and lasso-cox analysis identified the genes highly associated with the immune phenotype: BTK and DPEP2. The risk signature, consisting of BTK and DPEP2, is highly correlated with the immune phenotype. High-risk scores were enriched in patients with immune cold phenotype and low-risk scores were enriched in patients with immune hot phenotype. Compared to the high-risk group, the low-risk group had better clinical performance, higher drug sensitivity, and a higher degree of immunoactivity, as well as better efficacy in receiving immunotherapy and common adjuvant therapy. This study developed an immune indicator consisting of BTK and DPEP2 based on the heterogeneity of hot and cold Immunophenotypes of the tumor microenvironment. This indicator has good efficacy in predicting prognosis and assessing the efficacy of immunotherapy, chemotherapy, and radiotherapy. It has the potential to facilitate personalized and precise treatment of LUAD in the future.

430. Oncogenic epidermal growth factor receptor signal-induced histone deacetylation suppresses chemokine gene expression in human lung adenocarcinoma.

Sci Rep

2023 Mar 29

Sumimoto H, Takano A, Igarashi T

431. Increasing peak intensity of tropical cyclones passing through the Korean Peninsula.

Sci Rep

2023 Mar 29

Basconcillo J, Moon IJ.

432. Automated high-throughput image processing as part of the screening platform for personalized oncology.

Sci Rep

2023 Mar 29

Schilling MP, El Khaled El Faraj R, Urrutia Gómez JE

433. DTUMOS, digital twin for large-scale urban mobility operating system.

Sci Rep

2023 Mar 29

Yeon H(#), Eom T(#), Jang K

434. Nanocomposite formulation for a sustained release of free drug and drug-loaded responsive nanoparticles: an approach for a local therapy of glioblastoma multiforme.

Sci Rep

2023 Mar 29

Erthal LCS, Shi Y, Sweeney KJ

435. Effect of oxidation at an elevated temperature on the evolution of phases, microstructure, and properties of the oxide films formed on the surface of TiZr.

Sci Rep

2023 Mar 29

Chang SH, Li ZY.

436. Co-drawing of technical and high-performance thermoplastics with glasses via the molten core method.

Sci Rep

2023 Mar 29

Strutynski C, Voivenel R, Evrard M

437. Effects of acidifiers on soil greenhouse gas emissions in calcareous soils in a semi-arid area.

Sci Rep

2023 Mar 29

Derafshi M, Asgari Lajayer B, Hassani A

438. Designing and fabrication of electrochemical nano-biosensor for the fast detection of SARS-CoV-2-RNA.

Sci Rep

2023 Mar 29

Hussein HA, Hanora A, Solyman SM

439. Visual augmentation of deck-landing-ability improves helicopter ship landing decisions.

Sci Rep

2023 Mar 29

Thomas M, Serres JR, Rakotomamonjy T

440. Proteomics analysis of serum from thymoma patients.

Sci Rep

2023 Mar 29

Li J, Qi G, Liu Y.

Thymoma is the most common malignant tumor in thymic epithelial tumors (TETS). This study aimed to identify the changes in serum proteomics in patients with thymoma. Proteins were extracted from twenty patients with thymoma serum and nine healthy controls and prepared for mass spectrometry (MS) analysis. Data independent acquisition (DIA) quantitative proteomics technique was used to examine the serum proteome. Differential proteins of abundance changes in the serum were identified. Bioinformatics was used to examine the differential proteins. Functional tagging and enrichment analysis were conducted using the Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) databases. The string database was used to assess the interaction of different proteins. In all, 486 proteins were found in all samples. There were differences in 58 serum proteins between patients and healthy blood donors, 35 up-regulated and 23 down-regulated. These proteins are primarily exocrine and serum membrane proteins involved in controlling immunological responses and antigen binding, according to GO functional annotation. KEGG functional annotation showed that these proteins play a significant role in the complement and coagulation cascade and the phosphoinositide 3-kinase (PI3K)/protein kinase B (AKT) signal pathway. Notably, the KEGG pathway (complement and coagulation cascade) is enriched, and three key activators were up-regulated: von willebrand factor (VWF), coagulation factor v (F5) and vitamin k-dependent protein c (PC). Protein-protein interaction (PPI) analysis showed that six proteins ((VWF, F5, thrombin reactive protein 1 (THBS1), mannose-binding lectin-associated serine protease 2 (MASP2), apolipoprotein B (APOB), and apolipoprotein (a) (LPA)) were up-regulated and two proteins (Metalloproteinase inhibitor 1(TIMP1), ferritin light chain (FTL)) were down-regulated. The results of this study showed that several proteins involved in complement and coagulation cascades were up-regulated in the serum of patients.

441. Experimental study on tilting deformation and a new method for landslide prediction with retaining-wall locked segment.

Sci Rep

2023 Mar 29

Liu HD, Liu JJ, Chen JX

442. Application of image processing and transfer learning for the detection of rust disease.

Sci Rep

2023 Mar 29

Shahoveisi F, Taheri Gorji H, Shahabi S

443. Multivariate indicators of disease severity in COVID-19.

Sci Rep

2023 Mar 29

Bean J, Kuri-Cervantes L, Pennella M

444. Thermochemical process and compact apparatus for concentrating oxygen in extraterrestrial atmospheres: a feasibility study.

Sci Rep

2023 Mar 29

Eltayeb A, Klaas L, Kölz L

445. Transcriptomics of CD29(+)/CD44(+) cells isolated from hPSC retinal organoids reveals a single cell population with retinal progenitor and Müller glia characteristics.

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2023 Mar 28

Eastlake K, Luis J, Wang W

446. Evaluation of local oxygen flux produced by photoelectrochemical hydroxide oxidation by scanning electrochemical microscopy.

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2023 Mar 28

Gupta B, Aziz A, Sundriyal S

447. Microwave demonstration of Purcell effect enhanced radiation efficiency.

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2023 Mar 28

Stanfield LD, Powell AW, Horsley SAR

448. Physicochemical and thermomechanical performances study for Timahdite sheep wool fibers application in the building's insulation.

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2023 Mar 28

Atbir A, Taibi M, Aouan B

449. Comparison of mental health indicators in clinical psychologists with the general population during the COVID-19 pandemic.

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2023 Mar 28

Humer E, Pammer B, Schaffler Y

450. Characteristics of external loads of Hockey5s associated with the new version of U16 youth field hockey competition.

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2023 Mar 28

Konarski JM, Andrzejewski M, Konefał M

451. Effect of adding nano-materials on the properties of hydroxypropyl methylcellulose (HPMC) edible films.

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2023 Mar 28

Khater ES, Bahnasawy A, Gabal BA

452. Associations of cognitive impairment with self-isolation and access to health and care during the COVID-19 pandemic in England.

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2023 Mar 28

Beach B, Steel N, Steptoe A

453. Development of loop-mediated isothermal amplification (LAMP) assays using five primers reduces the false-positive rate in COVID-19 diagnosis.

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2023 Mar 28

Alhamid G, Tombuloglu H, Al-Suhaimi E.

454. The influence of the BDNF Val66Met genotype on emotional recognition memory in post-traumatic stress disorder.

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2023 Mar 28

Nicholson EL, Garry MI, Ney LJ

455. Unusual microwave heating of water in reverse micellar solution.

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2023 Mar 28

Murakami H.

456. Intuitionistic fuzzy fairly operators and additive ratio assessment-based integrated model for selecting the optimal sustainable industrial building options.

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2023 Mar 28

Mishra AR, Rani P, Cavallaro F

In the past few years, the private sectors and industries have focused their attention on sustainable development goals to achieve the better and more sustainable future for all. To accomplish a sustainable community, one requires to better recognize the fundamental indicators and selects the most suitable sustainable policies in diverse regions of the community. Considering the huge impact of construction industry on sustainable development, very less research efforts have been made to obtain worldwide sustainable elucidations for this type of industry. As a large sector of construction industry, industrial buildings consume enormous amounts of energy and financial assets, and play a key character in job creation and life quality improvement in the community. In order to assess the sustainable industrial buildings by means of multiple indicators, the present study introduces a hybrid multi-criteria decision-making methodology which integrates the fairly aggregation operator, the MEthod based on the Removal Effects of Criteria (MEREC), the stepwise weight assessment ratio analysis (SWARA) and the additive ratio assessment (ARAS) methods with intuitionistic fuzzy set (IFS). In this respect, firstly new intuitionistic fuzzy weighted fairly aggregation operators are proposed and then employed to aggregate the decision information in the proposed hybrid method. This operator overcomes the limitations of basic intuitionistic fuzzy aggregation operators. To find the criteria weights, an integrated model is presented based on the MEREC for objective weights and the SWARA for subjective weights of indicators under IFS context. To rank the sustainable industrial buildings, an integrated ARAS method is employed from uncertain perspective. Further, a case study concerning sustainable industrial buildings evaluation is presented to illustrate the superiority and practicality of the developed methodology. The advantages of the developed approach are highlighted in terms of stability and reliability by comparison with some of the existing methods.

457. Investigation of optimal gestational weight gain for twin pregnancy in Southwest China: a retrospective study.

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2023 Mar 28

Gao L(#), Lei C(#), Zhou S

458. Fluctuating sea-level and reversing Monsoon winds drive Holocene lagoon infill in Southeast Asia.

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2023 Mar 28

Kappelmann Y, Westphal H, Kneer D

459. In vitro wound healing potential of cyclohexane extract of Onosma dichroantha Boiss. based on bioassay-guided fractionation.

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2023 Mar 28

Safavi F, Moridi Farimani M, Golalipour M

460. Nano‑zinc enhances gene regulation of non‑specific immunity and antioxidative status to mitigate multiple stresses in fish.

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2023 Mar 28

Kumar N, Singh DK, Chandan NK

The toxicity of ammonia surged with arsenic pollution and high temperature (34 °C). As climate change enhances the pollution in water bodies, however, the aquatic animals are drastically affected and extinct from nature. The present investigation aims to mitigate arsenic and ammonia toxicity and high-temperature stress (As + NH3 + T) using zinc nanoparticles (Zn-NPs) in Pangasianodon hypophthalmus. Zn-NPs were synthesized using fisheries waste to developing Zn-NPs diets. The four isonitrogenous and isocaloric diets were formulated and prepared. The diets containing Zn-NPs at 0 (control), 2, 4 and 6 mg kg-1 diets were included. Superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx) and glutathione-s-transferase (GST) were noticeably improved using Zn-NPs diets in fish reared under with or without stressors. Interestingly, lipid peroxidation was significantly reduced, whereas vitamin C and acetylcholine esterase were enhanced with supplementation of Zn-NPs diets. Immune-related attributes such as total protein, globulin, albumin, myeloperoxidase (MPO), A:G ratio, and NBT were also improved with Zn-NPs at 4 mg kg-1 diet. The immune-related genes such as immunoglobulin (Ig), tumor necrosis factor (TNFα), and interleukin (IL1b) were strengthening in the fish using Zn-NPs diets. Indeed, the gene regulations of growth hormone (GH), growth hormone regulator (GHR1), myostatin (MYST) and somatostatin (SMT) were significantly improved with Zn-NPs diets. Blood glucose, cortisol and HSP 70 gene expressions were significantly upregulated by stressors, whereas the dietary Zn-NPs downregulated the gene expression. Blood profiling (RBC, WBC and Hb) was reduced considerably with stressors (As + NH3 + T), whereas Zn-NPs enhanced the RBC, WBC, and Hb count in fish reread in control or stress conditions. DNA damage-inducible protein gene and DNA damage were significantly reduced using Zn-NPs at 4 mg kg-1 diet. Moreover, the Zn-NPs also enhanced the arsenic detoxification in different fish tissues. The present investigation revealed that Zn-NPs diets mitigate ammonia and arsenic toxicity, and high-temperature stress in P. hypophthalmus.

461. A novel method for in-situ extracting bio-impedance model parameters optimized for embedded hardware.

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2023 Mar 28

Simić M, Freeborn TJ, Šekara TB

462. Photonic sintering of copper for rapid processing of thick film conducting circuits on FTO coated glass.

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2023 Mar 28

Abbas B, Jewell E, Lau YC

463. A finite element analysis of different postures and intra-abdominal pressures for the uterine ligaments in maintaining the normal position of uterus.

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2023 Mar 28

Chen J, Zhang J, Wang F.

464. Overlap in meaning is a stronger predictor of semantic activation in GPT-3 than in humans.

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2023 Mar 28

Digutsch J, Kosinski M.

465. Long-term intensive management reduced the soil quality of a Carya dabieshanensis forest.

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2023 Mar 28

Huang C(#), Fu S(#), Ma X

The evaluation of soil quality can provide new insights into the sustainable management of forests. This study investigated the effects of three types of forest management intensities (non-management (CK), extensive management (EM), and intensive management (IM)), and five management durations (0, 3, 8, 15, and 20 years) on the soil quality of a Carya dabieshanensis forest. Further, minimum data sets (MDS) and optimized minimum data sets (OMDS) were established to evaluate the soil quality index (SQI). A total of 20 soil indicators representing its physical, chemical, and biological properties were measured for the 0-30 cm layer. Using one-way ANOVA and principal component analysis (PCA), the total data set (TDS), the minimum data set (MDS), and optimized minimum data set (OMDS) were established. The MDS and OMDS contained three (alkali hydrolyzed nitrogen (AN), soil microbial biomass nitrogen (SMBN), and pH) and four (total phosphorus (TP), soil organic carbon (SOC), AN, and bulk density (BD)) soil indicators, respectively. The SQI derived from the OMDS and TDS exhibited a stronger correlation (r = 0.94, p < 0.01), which was suitable for evaluating the soil quality of the C. dabieshanensis forest. The evaluation results revealed that the soil quality was highest during the early stage of intensive management (IM-3), and the SQI of each soil layer was 0.81 ± 0.13, 0.47 ± 0.11, and 0.38 ± 0.07, respectively. With extended management times, the degree of soil acidification increased, and the nutrient content decreased. Compared with the untreated forest land the soil pH, SOC, and TP decreased by 2.64-6.24%, 29.43-33.04%, and 43.63-47.27%, respectively, following 20 years of management, while the SQI of each soil layer decreased to 0.35 ± 0.09, 0.16 ± 0.02 and 0.12 ± 0.06, respectively. In contrast to extensive management, the soil quality deteriorated more rapidly under longer management and intensive supervision. The OMDS established in this study provides a reference for the assessment of soil quality in C. dabieshanensis forests. In addition, it is suggested that the managers of C. dabieshanensis forests should implement measures such as increasing the amount of P-rich organic fertilizer and restoring vegetation to increase soil nutrient resources for the gradual restoration of soil quality.

466. Ameliorative effects of zinc supplementation on cognitive function and hippocampal leptin signaling pathway in obese male and female rats.

Sci Rep

2023 Mar 28

Hafez LM, Aboudeya HM, Matar NA

467. Outer nuclear layer recovery as a predictor of visual prognosis in type 1 choroidal neovascularization of neovascular age-related macular degeneration.

Sci Rep

2023 Mar 28

Lee S, Kim KT, Kim DY

468. UV-Visible-NIR camouflage textiles with natural plant based natural dyes on natural fibre against woodland combat background for defence protection.

Sci Rep

2023 Mar 28

Hossain MA.

Woodland combat background (CB) is a common source of natural plant based natural dyes (NPND). Swietenia Macrophylla, Mangifera Indica, Terminalia Arjuna, Corchorus Capsularis, Camellia Sinensis, Azadirachta Indica, Acacia Acuminata, Areca Catechu and Cinnamomum Tamala were dried-grinded-powdered-extracted-polyaziridine encapsulated-dyed-coated-printed with leafy design on cotton fabric and tested against woodland CB under the reflection engineering of ultraviolet (UV)-visible (Vis)-near infrared (NIR) spectrums and photographic versus chromatic techniques of Vis imaging. The reflection properties of NPND treated and untreated cotton fabric were experimented by UV-Vis-NIR spectrophotometer from 220 to 1400 nm. Six segments of field trialling for NPND treated woodland camouflage textiles were also investigated for concealment, detection, recognition and identification of target signature against forest plants/herbs species; common tree of woodland CB such as Shorea Robusta Gaertn, Bamboo Vulgaris, Musa Acuminata; and a wooden bridge made by Eucalyptus Citriodora & Bamboo Vulgaris. The imaging properties such as CIE L*, a*, b* and RGB (red, green, blue) of NPND treated cotton-garments were captured by digital camera from 400 to 700 nm against tree stem/bark, dry leaves, green leaves and dry wood of woodland CB. Therefore, a colorful matching for concealment, detection, recognition and identification of target signature against woodland CB was verified by Vis camera imaging and UV-Vis-NIR reflection mechanism. UV-protection property of Swietenia Macrophylla treated cotton fabric was also investigated by diffuse reflection for defence clothing. Simultaneous 'camouflage textiles in UV-Vis-NIR' and 'UV-protective' property of Swietenia Macrophylla treated fabric have been investigated for NPND materials-based textiles coloration (dyeing-coating-printing) which is a new concept for camouflage formulation of NPND dyed-NPND mordanted-NPND coated-NPND printed textiles in terms of ecofriendly source of woodland camouflage materials. Therefore, technical properties of NPND materials and methodologies of camouflage textile assessment have been advanced in addition to coloration philosophy of natural dyed-coated-printed textiles.

469. Numerically analysis of Marangoni convective flow of hybrid nanofluid over an infinite disk with thermophoresis particle deposition.

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2023 Mar 28

Abbas M, Khan N, Hashmi MS

470. Beyond the spore, the exosporium sugar anthrose impacts vegetative Bacillus anthracis gene regulation in cis and trans.

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2023 Mar 28

Norris MH, Bluhm AP, Metrailer MC

471. Environmental remediation at vegetable marketplaces through production of biowaste catalysts for biofuel generation.

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2023 Mar 28

Sathish T, Saravanan R, Depoures MV

472. Integrated assessment of the impact of land use changes on groundwater recharge and groundwater level in the Drava floodplain, Hungary.

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2023 Mar 28

Salem A, Abduljaleel Y, Dezső J

473. Relationship between facial skin problems with a focus on inflammatory cytokines and the presence of Malassezia in 1-month-old infants.

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2023 Mar 28

Shimizu S, Yonezawa K, Haruna M

474. Atomic scale interfacial magnetism and origin of metal-insulator transition in (LaNiO[Formula: see text])[Formula: see text]/(CaMnO[Formula: see text])[Formula: see text] superlattices: a first principles study.

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2023 Mar 28

Jilili J, Tolbatov I, Cossu F

Interfacial magnetism and metal-insulator transition at LaNiO[Formula: see text]-based oxide interfaces have triggered intense research efforts, because of the possible implications in future heterostructure device design and engineering. Experimental observation lack in some points a support from an atomistic view. In an effort to fill such gap, we hereby investigate the structural, electronic, and magnetic properties of (LaNiO[Formula: see text])[Formula: see text]/(CaMnO[Formula: see text])[Formula: see text] superlattices with varying LaNiO[Formula: see text] thickness (n) using density functional theory including a Hubbard-type effective on-site Coulomb term. We successfully capture and explain the metal-insulator transition and interfacial magnetic properties, such as magnetic alignments and induced Ni magnetic moments which were recently observed experimentally in nickelate-based heterostructures. In the superlattices modeled in our study, an insulating state is found for n=1 and a metallic character for n=2, 4, with major contribution from Ni and Mn 3d states. The insulating character originates from the disorder effect induced by sudden environment change for the octahedra at the interface, and associated to localized electronic states; on the other hand, for larger n, less localized interfacial states and increased polarity of the LaNiO[Formula: see text] layers contribute to metallicity. We discuss how the interplay between double and super-exchange interaction via complex structural and charge redistributions results in interfacial magnetism. While (LaNiO[Formula: see text])[Formula: see text]/(CaMnO[Formula: see text])[Formula: see text] superlattices are chosen as prototype and for their experimental feasibility, our approach is generally applicable to understand the intricate roles of interfacial states and exchange mechanism between magnetic ions towards the overall response of a magnetic interface or superlattice.

475. A low dose of RBD and TLR7/8 agonist displayed on influenza virosome particles protects rhesus macaque against SARS-CoV-2 challenge.

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2023 Mar 28

Koopman G, Amacker M, Stegmann T

476. Transformation and expressional studies of GaZnF gene to improve drought tolerance in Gossypium hirsutum.

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2023 Mar 28

Batool F, Hassan S, Azam S

477. Individual differences in selective attention and engagement shape students' learning from visual cues and instructor presence during online lessons.

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2023 Mar 28

King J, Marcus T, Markant J.

478. Water-sulfur-rich, oxidised adakite magmas are likely porphyry copper progenitors.

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2023 Mar 28

Leong TSJ, Mavrogenes JA, Arculus RJ.

479. A residue management machine for chopping paddy residues in combine harvested paddy field.

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2023 Mar 28

Ramulu C, Pateriya RN, Naik MA

480. Early cellular events and potential regulators of cellulase induction in Penicillium janthinellum NCIM 1366.

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2023 Mar 28

Christopher M, Sreeja-Raju A, Abraham A

481. Evaluation of autoantibodies to desmoglein-2 in dogs with and without cardiac disease.

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2023 Mar 28

Walker AL, Li RHL, Nguyen N

482. Effect of thallus melanisation on the sensitivity of lichens to heat stress.

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2023 Mar 28

Chowaniec K, Latkowska E, Skubała K.

483. Lonafarnib and everolimus reduce pathology in iPSC-derived tissue engineered blood vessel model of Hutchinson-Gilford Progeria Syndrome.

Sci Rep

2023 Mar 28

Abutaleb NO(#), Atchison L(#), Choi L

484. Comprehensive pan-cancer analysis of STAT3 as a prognostic and immunological biomarker.

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2023 Mar 28

He Z(#), Song B(#), Zhu M

485. Iron response elements (IREs)-mRNA of Alzheimer's amyloid precursor protein binding to iron regulatory protein (IRP1): a combined molecular docking and spectroscopic approach.

Sci Rep

2023 Mar 28

Khan MA, Mohammad T, Malik A

The interaction between the stem-loop structure of the Alzheimer's amyloid precursor protein IRE mRNA and iron regulatory protein was examined by employing molecular docking and multi-spectroscopic techniques. A detailed molecular docking analysis of APP IRE mRNA∙IRP1 reveals that 11 residues are involved in hydrogen bonding as the main driving force for the interaction. Fluorescence binding results revealed a strong interaction between APP IRE mRNA and IRP1 with a binding affinity and an average binding sites of 31.3 × 106 M-1 and 1.0, respectively. Addition of Fe2+(anaerobic) showed a decreased (3.3-fold) binding affinity of APP mRNA∙IRP1. Further, thermodynamic parameters of APP mRNA∙IRP1 interactions were an enthalpy-driven and entropy-favored event, with a large negative ΔH (-25.7 ± 2.5 kJ/mol) and a positive ΔS (65.0 ± 3.7 J/mol·K). A negative ΔH value for the complex formation suggested the contribution of hydrogen bonds and van der Waals forces. The addition of iron increased the enthalpic contribution by 38% and decreased the entropic influence by 97%. Furthermore, the stopped-flow kinetics of APP IRE mRNA∙IRP1 also confirmed the complex formation, having the rate of association (kon) and the rate of dissociation (koff) as 341 μM-1 s-1, and 11 s-1, respectively. The addition of Fe2+ has decreased the rate of association (kon) by ~ three-fold, whereas the rate of dissociation (koff) has increased by ~ two-fold. The activation energy for APP mRNA∙IRP1 complex was 52.5 ± 2.1 kJ/mol. The addition of Fe2+ changed appreciably the activation energy for the binding of APP mRNA with IRP1. Moreover, circular dichroism spectroscopy has confirmed further the APP mRNA∙IRP1 complex formation and IRP1 secondary structure change with the addition of APP mRNA. In the interaction between APP mRNA and IRP1, iron promotes structural changes in the APP IRE mRNA∙IRP1 complexes by changing the number of hydrogen bonds and promoting a conformational change in the IRP1 structure when it is bound to the APP IRE mRNA. It further illustrates how IRE stem-loop structure influences selectively the thermodynamics and kinetics of these protein-RNA interactions.

486. Platelet to lymphocyte ratio was a risk factor in Perthes disease.

Sci Rep

2023 Mar 28

Wang T(#), Luo X(#), Li B

The study was aimed to determine the relationship between PLR (platelet to lymphocyte ratio) and the lateral pillar classification of Perthes disease, and to provide an alternative index for clinical diagnosis. In addition, the association of the PLR with the necrosis stage of Perthes disease was also explored. This was a retrospective study. 74 children with Perthes disease and 60 children in the healthy control group without femoral head necrosis in our hospital from 2012 to 2021 were collected. The general data and clinical parameters were collected from the hospital information system. The modified herring lateral pillar classification was collected for the fragmentation stage case group and the PLR, NLR (neutrophil to lymphocyte ratio), LMR (lymphocyte to monocyte ratio) and PNR (platelet to neutrophil ratio) were calculated. The cases were divided into four groups, herring A and B were group I, herring B/C and C were group II, the healthy control group was group III, and the necrosis stage was group IV. The hematological indexes (NLR, PLR, LMR, PNR) of children at different stages were statistically analyzed. Group I consisted of 36 patients, with an average age of 7.4 ± 2.0 years (3-11 years). Group II consisted of 23 patients, with an average age of 7.4 ± 1.9 years (4-12 years). Group III consisted of 60 patients, with a mean age of 7.4 ± 2.7 years (4-13 years). Group IV consisted of 15 patients, with an average age of 6.4 ± 1.7 years (3-10 years). The average values of PLR in groups I, II, III and IV were 131.98 ± 47.44, 122.19 ± 37.88, 102.46 ± 30.68 and 128.90 ± 28.11, respectively. It's worth noting that there was statistically significant difference among groups I, II and III (P = 0.003). The optimal threshold of PLR was 130.25, the sensitivity was 45.8% and the specificity was 85%. PLR was also significantly different between groups III and group IV. PLR was higher in Herring A and B classifications than in Herring B/C and C classifications. PLR had certain diagnostic value in both the necrosis stage and fragmentation stage as a risk factor.

487. Prospecting movements link phenotypic traits to female annual potential fitness in a nocturnal predator.

Sci Rep

2023 Mar 28

Becciu P, Séchaud R, Schalcher K

488. Effectiveness of a transactional model-based education programme for enhancing stress-coping skills in industrial workers: a randomized controlled trial.

Sci Rep

2023 Mar 28

Kaveh MH, Mehrazin F, Cousins R

489. Targeting Tn-positive tumors with an afucosylated recombinant anti-Tn IgG.

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2023 Mar 28

Matsumoto Y, Jia N, Heimburg-Molinaro J

490. Determinants of bone mass in older adults with normal- and overweight derived from the crosstalk with muscle and adipose tissue.

Sci Rep

2023 Mar 28

Walowski CO, Herpich C, Enderle J

491. Impact of radiation dose reduction and iterative image reconstruction on CT-guided spine biopsies.

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2023 Mar 28

Paprottka KJ, Kupfer K, Schultz V

492. A novel model of the continual reassessment method in Phase I trial.

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2023 Mar 28

Zhang W, Lei W, Zhu X.

493. A comparison of machine learning models' accuracy in predicting lower-limb joints' kinematics, kinetics, and muscle forces from wearable sensors.

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2023 Mar 28

Moghadam SM, Yeung T, Choisne J.

494. Vascular parameters and endothelin-1 measurements in glaucoma patients with low- and high-tension optic disc hemorrhages.

Sci Rep

2023 Mar 28

Almeida INF, Taniguchi E, Tito CVA

495. Development and validation of a risk prediction model for diabetic retinopathy in type 2 diabetic patients.

Sci Rep

2023 Mar 28

Zhu C(#), Zhu J(#), Wang L

To establish a risk prediction model and make individualized assessment for the susceptible diabetic retinopathy (DR) population in type 2 diabetic mellitus (T2DM) patients. According to the retrieval strategy, inclusion and exclusion criteria, the relevant meta-analyses on DR risk factors were searched and evaluated. The pooled odds ratio (OR) or relative risk (RR) of each risk factor was obtained and calculated for β coefficients using logistic regression (LR) model. Besides, an electronic patient-reported outcome questionnaire was developed and 60 cases of DR and non-DR T2DM patients were investigated to validate the developed model. Receiver operating characteristic curve (ROC) was drawn to verify the prediction accuracy of the model. After retrieving, eight meta-analyses with a total of 15,654 cases and 12 risk factors associated with the onset of DR in T2DM, including weight loss surgery, myopia, lipid-lowing drugs, intensive glucose control, course of T2DM, glycated hemoglobin (HbA1c), fasting plasma glucose, hypertension, gender, insulin treatment, residence, and smoking were included for LR modeling. These factors, followed by the respective β coefficient was bariatric surgery (- 0.942), myopia (- 0.357), lipid-lowering drug follow-up < 3y (- 0.994), lipid-lowering drug follow-up > 3y (- 0.223), course of T2DM (0.174), HbA1c (0.372), fasting plasma glucose (0.223), insulin therapy (0.688), rural residence (0.199), smoking (- 0.083), hypertension (0.405), male (0.548), intensive glycemic control (- 0.400) with constant term α (- 0.949) in the constructed model. The area under receiver operating characteristic curve (AUC) of the model in the external validation was 0.912. An application was presented as an example of use. In conclusion, the risk prediction model of DR is developed, which makes individualized assessment for the susceptible DR population feasible and needs to be further verified with large sample size application.

496. Applying T-classifier, binary classifiers, upon high-throughput TCR sequencing output to identify cytomegalovirus exposure history.

Sci Rep

2023 Mar 28

Zhou K(#), Huo J(#), Gao C

With the continuous development of information technology and the running speed of computers, the development of informatization has led to the generation of increasingly more medical data. Solving unmet needs such as employing the constantly developing artificial intelligence technology to medical data and providing support for the medical industry is a hot research topic. Cytomegalovirus (CMV) is a kind of virus that exists widely in nature with strict species specificity, and the infection rate among Chinese adults is more than 95%. Therefore, the detection of CMV is of great importance since the vast majority of infected patients are in a state of invisible infection after the infection, except for a few patients with clinical symptoms. In this study, we present a new method to detect CMV infection status by analyzing high-throughput sequencing results of T cell receptor beta chains (TCRβ). Based on the high-throughput sequencing data of 640 subjects from cohort 1, Fisher's exact test was performed to evaluate the relationship between TCRβ sequences and CMV status. Furthermore, the number of subjects with these correlated sequences to different degrees in cohort 1 and cohort 2 were measured to build binary classifier models to identify whether the subject was CMV positive or negative. We select four binary classification algorithms: logistic regression (LR), support vector machine (SVM), random forest (RF), and linear discriminant analysis (LDA) for side-by-side comparison. According to the performance of different algorithms corresponding to different thresholds, four optimal binary classification algorithm models are obtained. The logistic regression algorithm performs best when Fisher's exact test threshold is 10-5, and the sensitivity and specificity are 87.5% and 96.88%, respectively. The RF algorithm performs better at the threshold of 10-5, with a sensitivity of 87.5% and a specificity of 90.63%. The SVM algorithm also achieves high accuracy at the threshold value of 10-5, with a sensitivity of 85.42% and specificity of 96.88%. The LDA algorithm achieves high accuracy with 95.83% sensitivity and 90.63% specificity when the threshold value is 10-4. This is probably because the two-dimensional distribution of CMV data samples is linearly separable, and linear division models such as LDA are more effective, while the division effect of nonlinear separable algorithms such as random forest is relatively inaccurate. This new finding may be a potential diagnostic method for CMV and may even be applicable to other viruses, such as the infectious history detection of the new coronavirus.

497. Aerobic biodegradation of untreated polyester-polyether urethanes by newly isolated yeast strains Exophilia sp. NS-7 and Rhodotorula sp. NS-12.

Sci Rep

2023 Mar 28

Giyahchi M, Moghimi H.

498. Impact of coronavirus disease 2019 pandemic on breast cancer surgery using the National Database of Japan.

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2023 Mar 27

Fujita M, Hashimoto H, Nagashima K

499. Development of a risk prediction score and equation for chronic kidney disease: a retrospective cohort study.

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2023 Mar 27

Kawasoe S, Kubozono T, Salim AA

500. Comparison of posterior vitreous detachment-related and glaucomatous optic disc hemorrhage.

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2023 Mar 27

Jin C, Park GS, Kim KN

501. TEDC2 correlated with prognosis and immune microenvironment in lung adenocarcinoma.

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2023 Mar 27

Fang L, Yu W, Zhu P

502. Predicting and understanding human action decisions during skillful joint-action using supervised machine learning and explainable-AI.

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2023 Mar 27

Auletta F, Kallen RW, di Bernardo M

503. Spatial modelling of agro-ecologically significant grassland species using the INLA-SPDE approach.

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2023 Mar 27

Fichera A, King R, Kath J

504. Screening for or diagnosing medial meniscal root injury using peripheral medial joint space width ratio in plain radiographs.

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2023 Mar 27

Asawatreratanakul P, Boonriong T, Parinyakhup W

505. Effect of ocean acidification on the growth, response and hydrocarbon degradation of coccolithophore-bacterial communities exposed to crude oil.

Sci Rep

2023 Mar 27

Fahmi AM, Summers S, Jones M

506. Black coral forests enhance taxonomic and functional distinctiveness of mesophotic fishes in an oceanic island: implications for biodiversity conservation.

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2023 Mar 27

Bosch NE, Espino F, Tuya F

507. Metabolically healthy and unhealthy obesity and the development of lung dysfunction.

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2023 Mar 27

Song JU, Lee J, Lim SY

508. Performance evaluation of newly developed surrogate virus neutralization tests for detecting neutralizing antibodies against SARS-CoV-2.

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2023 Mar 27

Kweon OJ(#), Bae JY(#), Lim YK

509. Artificial homeostatic temperature regulation via bio-inspired feedback mechanisms.

Sci Rep

2023 Mar 27

Feketa P, Birkoben T, Noll M

Homeostasis comprises one of the main features of living organisms that enables their robust functioning by adapting to environmental changes. In particular, thermoregulation, as an instance of homeostatic behavior, allows mammals to maintain stable internal temperature with tightly controlled self-regulation independent of external temperatures. This is made by a proper reaction of the thermoeffectors (like skin blood vessels, brown adipose tissue (BAT), etc.) on a wide range of temperature perturbations that reflect themselves in the thermosensitive neurons' activity. This activity is being delivered to the respective actuation points and translated into thermoeffectors' actions, which bring the temperature of the organism to the desired level, called a set-point. However, it is still an open question whether these mechanisms can be implemented in an analog electronic device: both on a system theoretical and a hardware level. In this paper, we transfer this control loop into a real electric circuit by designing an analog electronic device for temperature regulation that works following bio-inspired principles. In particular, we construct a simplified single-effector regulation system and show how spiking trains of thermosensitive artificial neurons can be processed to realize an efficient feedback mechanism for the stabilization of the a priori unknown but system-inherent set-point. We also demonstrate that particular values of the set-point and its stability properties result from the interplay between the feedback control gain and activity patterns of thermosensitive artificial neurons, for which, on the one hand, the neuronal interconnections are generally not necessary. On the other hand, we show that such connections can be beneficial for the set-point regulation and hypothesize that the synaptic plasticity in real thermosensitive neuronal ensembles can play a role of an additional control layer empowering the robustness of thermoregulation. The electronic realization of temperature regulation proposed in this paper might be of interest for neuromorphic circuits which are bioinspired by taking the basal principle of homeostasis on board. In this way, a fundamental building block of life would be transferred to electronics and become a milestone for the future of neuromorphic engineering.

510. Radial-tangential mode of single-wall carbon nanotubes manifested by Landau regulation: reinterpretation of low- and intermediate-frequency Raman signals.

Sci Rep

2023 Mar 27

Hembram KPSS, Kim JG, Lee SG

511. Facile preparation of a cost-effective platform based on ZnFe(2)O(4) nanomaterials for electrochemical cell detection.

Sci Rep

2023 Mar 27

Vajhadin F, Mazloum-Ardakani M, Hemati M

512. Shotgun proteomics of quinoa seeds reveals chitinases enrichment under rainfed conditions.

Sci Rep

2023 Mar 27

Poza-Viejo L, Redondo-Nieto M, Matías J

513. Microwave-assisted synthesis, antioxidant activity, docking simulation, and DFT analysis of different heterocyclic compounds.

Sci Rep

2023 Mar 27

Shalaby MA, Fahim AM, Rizk SA.

514. Lack of furosemide responsiveness predict severe acute kidney injury after liver transplantation.

Sci Rep

2023 Mar 27

Cai L, Shu L, Yujun Z

515. Analysis of spatial-temporal dynamic distribution and related factors of tuberculosis in China from 2008 to 2018.

Sci Rep

2023 Mar 27

Xue M, Zhong J, Gao M

Through spatial-temporal scanning statistics, the spatial-temporal dynamic distribution of pulmonary tuberculosis incidence in 31 provinces and autonomous regions of China from 2008 to 2018 is obtained, and the related factors of spatial-temporal aggregation of tuberculosis in China are analyzed to provide strong scientific basis and data support for the prevention and control of pulmonary tuberculosis. This is a retrospective study, using spatial epidemiological methods to reveal the spatial-temporal clustering distribution characteristics of China's tuberculosis epidemic from 2008 to 2018, in which cases data comes from the China Center for Disease Control and prevention. Office Excel is used for general statistical description, and the single factor correlation analysis adopts χ2 Test (or trend χ2 Inspection). Retrospective discrete Poisson distribution space time scanning statistics of SaTScan 9.6 software are used to analyze the space time dynamic distribution of tuberculosis incidence in 31 provinces, cities and autonomous regions in China from 2008 to 2018. ArcGIS 10.2 software is used to visualize the results. The global spatial autocorrelation analysis adopts Moran's I of ArcGIS Map(Monte Carlo randomization simulation times of 999) is used to analyze high-risk areas, low-risk areas and high-low risk areas. From 2008 to 2018, 10,295,212 cases of pulmonary tuberculosis were reported in China, with an average annual incidence rate of 69.29/100,000 (95% CI: (69.29 ± 9.16)/100,000). The annual GDP (gross domestic product) of each province and city showed an upward trend year by year, and the number of annual medical institutions in each province and city showed a sharp increase in 2009, and then tended to be stable; From 2008 to 2018, the national spatiotemporal scanning statistics scanned a total of 6 clusters, including 23 provinces and cities. The national high-low spatiotemporal scanning statistics of the number of pulmonary tuberculosis cases scanned a total of 2 high-risk and low-risk clusters. The high-risk cluster included 8 provinces and cities, and the low-risk cluster included 12 provinces and cities. The global autocorrelation Moran's I index of the incidence rate of pulmonary tuberculosis in all provinces and cities was greater than the expected value (E (I) = -0.0333); The correlation analysis between the average annual GDP and the number of pulmonary tuberculosis cases in each province and city from 2008 to 2018 was statistically significant. From 2008 to 2018, the spatial and temporal scanning and statistical scanning areas of tuberculosis incidence in China were mainly concentrated in the northwest and southern regions of China. There is an obvious positive spatial correlation between the annual GDP distribution of each province and city, and the aggregation degree of the development level of each province and city is increasing year by year. There is a correlation between the average annual GDP of each province and the number of tuberculosis cases in the cluster area. There is no correlation between the number of medical institutions set up in each province and city and the number of pulmonary tuberculosis cases.

516. Genetic risk of depression is different in subgroups of dietary ratio of tryptophan to large neutral amino acids.

Sci Rep

2023 Mar 27

Bruncsics B(#), Hullam G(#), Bolgar B(#)

Manipulation of intake of serotonin precursor tryptophan has been exploited to rapidly induce and alleviate depression symptoms. While studies show that this latter effect is dependent on genetic vulnerability to depression, the effect of habitual tryptophan intake in the context of predisposing genetic factors has not been explored. Our aim was to investigate the effect of habitual tryptophan intake on mood symptoms and to determine the effect of risk variants on depression in those with high and low tryptophan intake in the whole genome and specifically in serotonin and kynurenine pathways. 63,277 individuals in the UK Biobank with data on depressive symptoms and tryptophan intake were included. We compared two subpopulations defined by their habitual diet of a low versus a high ratio of tryptophan to other large amino acids (TLR). A modest protective effect of high dietary TLR against depression was found. NPBWR1 among serotonin genes and POLI in kynurenine pathway genes were significantly associated with depression in the low but not in the high TLR group. Pathway-level analyses identified significant associations for both serotonin and kynurenine pathways only in the low TLR group. In addition, significant association was found in the low TLR group between depressive symptoms and biological process related to adult neurogenesis. Our findings demonstrate a markedly distinct genetic risk profile for depression in groups with low and high dietary TLR, with association with serotonin and kynurenine pathway variants only in case of habitual food intake leading to low TLR. Our results confirm the relevance of the serotonin hypothesis in understanding the neurobiological background of depression and highlight the importance of understanding its differential role in the context of environmental variables such as complexity of diet in influencing mental health, pointing towards emerging possibilities of personalised prevention and intervention in mood disorders in those who are genetically vulnerable.

517. A new class of Poisson Ridge-type estimator.

Sci Rep

2023 Mar 27

Ertan E, Akay KU.

518. Endocannabinoid administration affects taste preference and the expression of cannabinoid and opioid receptors in the amygdala of early lactating cows.

Sci Rep

2023 Mar 27

Schwerdtfeger J, Krause A, Kalbe C

519. Face masks negatively skew theory of mind judgements.

Sci Rep

2023 Mar 27

Leos H, Gold I, Pérez-Gay Juárez F.

520. A survey on dogs with valvular disease flying to Japan for operation.

Sci Rep

2023 Mar 27

Takahashi A, Takeuchi S, Chen A

521. Increased SARS-CoV-2 seroprevalence and spread of infection without awareness among healthcare workers through 2020-2022 in a Japanese medical center.

Sci Rep

2023 Mar 27

Kanamori R, Yan Y, Ito K

522. Exploiting machine learning models to identify novel Alzheimer's disease biomarkers and potential targets.

Sci Rep

2023 Mar 27

Alamro H, Thafar MA, Albaradei S

523. Investigating TSPO levels in occupation-related posttraumatic stress disorder.

Sci Rep

2023 Mar 27

Watling SE, Gill T, Gaudette EV

524. Application of machine learning in predicting non-alcoholic fatty liver disease using anthropometric and body composition indices.

Sci Rep

2023 Mar 27

Razmpour F(#), Daryabeygi-Khotbehsara R(#), Soleimani D

525. Indicator-based approach for fluvial flood risk assessment at municipal level in Slovakia.

Sci Rep

2023 Mar 27

Vojtek M.

526. Brain injury biomarkers do not predict delirium in acutely ill older patients: a prospective cohort study.

Sci Rep

2023 Mar 27

de Alencar JCG, Garcez FB, Pinto AAS

527. Study on the vertical bearing performances of piles on karst cave.

Sci Rep

2023 Mar 27

Chen H, Feng Z, Wu M

528. The spatial spillover effect of higher SO(2) emission tax rates on PM(2.5) concentration in China.

Sci Rep

2023 Mar 27

Wang K, Liu Y, Wang S

529. Intracellular invertase hyperproducing strain of Saccharomyces cerevisiae isolated from Abagboro palm wine.

Sci Rep

2023 Mar 27

Osiebe O, Adewale IO, Omafuvbe BO.

530. Arabic gum ameliorates systemic modulation in Alloxan monohydrate-induced diabetic rats.

Sci Rep

2023 Mar 27

Ibrahim RM, Abdelhafez HM, El-Shamy SAE

531. Assessing the structure of the posterior visual pathway in bilateral macular degeneration.

Sci Rep

2023 Mar 27

Brown HDH, Gale RP, Gouws AD

532. Comparative physiological and biochemical mechanisms in diploid, triploid, and tetraploid watermelon (Citrullus lanatus L.) grafted by branches.

Sci Rep

2023 Mar 27

Kaseb MO, Umer MJ, Lu X

533. Interhemispheric interplay between the left and right premotor cortex during grasping as assessed by dynamic causal modelling.

Sci Rep

2023 Mar 27

Bencivenga F, Tullo MG, Sulpizio V

534. Cross over to collective rearrangements near the dry-wet transition in two-dimensional foams.

Sci Rep

2023 Mar 27

Yanagisawa N, Kurita R.

535. Repertoire of P-glycoprotein drug transporters in the zoonotic nematode Toxocara canis.

Sci Rep

2023 Mar 27

Jesudoss Chelladurai JRJ, Martin KA, Vardaxis P

536. Unveiling the local structure of the amorphous metal [Formula: see text] combining first-principles-based simulations and modelling of EXAFS spectra.

Sci Rep

2023 Mar 27

Muscas G, Johansson R, George S

537. Reshaping healthcare with wearable biosensors.

Sci Rep

2023 Mar 27

Smith AA, Li R, Tse ZTH.

538. Deep neural network training method based on vectorgraphs for designing of metamaterial broadband polarization converters.

Sci Rep

2023 Mar 27

Gao J, Feng C, Wu X(#)

539. Cloning, characterization, and heterologous expression of a candidate Hirudin gene from the salivary gland transcriptome of Hirudo nipponia.

Sci Rep

2023 Mar 27

Shi P(#), Wei J(#), You H

540. Tunable deterministic lateral displacement of particles flowing through thermo-responsive hydrogel micropillar arrays.

Sci Rep

2023 Mar 27

Tottori N, Nisisako T.

541. Lifestyle modification and medication use among diabetes mellitus patients attending Jimma University Medical Center, Jimma zone, south west Ethiopia.

Sci Rep

2023 Mar 27

Garedow AW, Jemaneh TM, Hailemariam AG

Diabetes, a non-communicable metabolic disease, causes multiple complications and deaths worldwide. It is a complex, chronic disease that requires continuous medical care with multifactorial risk reduction strategies beyond glycemic control. Ongoing patient education and self-management support are critical for preventing acute complications and reducing the risk of long-term complications. There is ample evidence that healthy lifestyle choices, such as a healthy diet, moderate weight loss, and regular exercise, can maintain normal blood sugar levels and minimize diabetes-related complications. In addition, this lifestyle change has a major impact on controlling hyperglycemia and can help to maintain normal blood sugar levels. This study aimed to assess lifestyle modification and medication use in patients with diabetes mellitus at Jimma University Medical Center. Hospital-based prospective cross-sectional study was conducted from April 1 to September 30, 2021 among DM patients who have follow-up at diabetic clinic of Jimma University Medical Center. Consecutive sampling was used until the required sample size was achieved. Data were checked for completeness, then entered into Epidata version 4.2 software and exported to SPSS version 21.0. Pearson's chi-square test was performed to determine the association between KAP and independent factors. Variables with a p value < 0.05 were considered significant. A total of 190 participants took part in this study with a response rate of 100%. In this study, 69 (36.3%) participants had good knowledge, 82 (43.2%) moderate knowledge and 39 (20.5%) poor knowledge, 153 (85.8%) had positive attitudes, 141 (74.2%) had good practice. Marital status, Occupational status and educational status were significantly associated with knowledge and attitude towards LSM and medication use. Marital status was the only variable that remained significantly associated with knowledge, attitude and practice towards LSM and medication use. The result of this study showed that more than 20% of the participants had poor knowledge, attitude, and practice towards medication use and LSM. Marital status was the only variable which remained to be significantly associated with KAP towards LSM and medication use.

542. Magnetothermal-based non-invasive focused magnetic stimulation for functional recovery in chronic stroke treatment.

Sci Rep

2023 Mar 27

Kim H, Kim J, Kim J

543. Time course of muscle activation, energetics and mechanics of running in minimalist and traditional cushioned shoes during level running.

Sci Rep

2023 Mar 27

Udin G, Fernandez Menendez A, Hoyois J

544. Importance of ipsilateral residual hearing for spatial hearing by bimodal cochlear implant users.

Sci Rep

2023 Mar 27

Thomas M, Galvin JJ 3rd, Fu QJ.

545. The long-term reproducibility of the white-coat effect on blood pressure as a continuous variable from the Ohasama Study.

Sci Rep

2023 Mar 27

Satoh M, Yoshida T, Metoki H

546. Developmental enamel defects and their relationship with caries in adolescents aged 18 years.

Sci Rep

2023 Mar 27

Olczak-Kowalczyk D, Krämer N, Gozdowski D

547. Wearable coupled-quarter-mode SIW antenna platform with hybrid kinetic and ambient-light energy harvesting.

Sci Rep

2023 Mar 27

Jocqué J, Verhaevert J, Van Torre P

548. Clinical features and shared mechanisms of chronic gastritis and osteoporosis.

Sci Rep

2023 Mar 27

Han T(#), Zhang Y(#), Qi B(#)

Chronic gastritis (CG) and osteoporosis (OP) are common and occult diseases in the elderly and the relationship of these two diseases have been increasingly exposed. We aimed to explore the clinical characteristics and shared mechanisms of CG patients combined with OP. In the cross-sectional study, all participants were selected from BEYOND study. The CG patients were included and classified into two groups, namely OP group and non-OP group. Univariable and multivariable logistic regression methods were used to evaluate the influencing factors. Furthermore, CG and OP-related genes were obtained from Gene Expression Omnibus (GEO) database. Differentially expressed genes (DEGs) were identified using the GEO2R tool and the Venny platform. Protein-protein interaction information was obtained by inputting the intersection targets into the STRING database. The PPI network was constructed by Cytoscape v3.6.0 software again, and the key genes were screened out according to the degree value. Gene function enrichment of DEGs was performed by Webgestalt online tool. One hundred and thirty CG patients were finally included in this study. Univariate correlation analysis showed that age, gender, BMI and coffee were the potential influencing factors for the comorbidity (P < 0.05). Multivariate Logistic regression model found that smoking history, serum PTH and serum β-CTX were positively correlated with OP in CG patients, while serum P1NP and eating fruit had an negative relationship with OP in CG patients. In studies of the shared mechanisms, a total of 76 intersection genes were identified between CG and OP, including CD163, CD14, CCR1, CYBB, CXCL10, SIGLEC1, LILRB2, IGSF6, MS4A6A and CCL8 as the core genes. The biological processes closely related to the occurrence and development of CG and OP mainly involved Ferroptosis, Toll-like receptor signaling pathway, Legionellosis and Chemokine signaling pathway. Our study firstly identified the possible associated factors with OP in the patients with CG, and mined the core genes and related pathways that could be used as biomarkers or potential therapeutic targets to reveal the shared mechanisms.

549. CRISPR-assisted test for Schistosoma haematobium.

Sci Rep

2023 Mar 27

Cherkaoui D, Mesquita SG, Huang D

550. Modelling the impact of historic landscape change on soil erosion and degradation.

Sci Rep

2023 Mar 27

Brandolini F, Kinnaird TC, Srivastava A

551. Dynamic changes in Shiga toxin (Stx) 1 transducing phage throughout the evolution of O26:H11 Stx-producing Escherichia coli.

Sci Rep

2023 Mar 27

Yano B, Taniguchi I, Gotoh Y

552. Facile assembly of flexible quaternary SnO(2)/SrSnO(3)/Fe(3)O(4)/PVDF nanocomposites with tunable optical, electrical, and magnetic properties for promising magneto-optoelectronic applications.

Sci Rep

2023 Mar 27

Ismail AM, El Desouky FG.

553. Striatal dopamine D2-like receptors availability in obesity and its modulation by bariatric surgery: a systematic review and meta-analysis.

Sci Rep

2023 Mar 27

Ribeiro G, Maia A, Cotovio G

554. Graphene nanoparticles as data generating digital materials in industry 4.0.

Sci Rep

2023 Mar 27

Ali MA, Irfan MS, Khan T

555. Long term nitrogen deficiency alters expression of miRNAs and alters nitrogen metabolism and root architecture in Indian dwarf wheat (Triticum sphaerococcum Perc.) genotypes.

Sci Rep

2023 Mar 27

Das S(#), Singh D, Meena HS

556. Optimum design and performance of a base-isolated structure with tuned mass negative stiffness inerter damper.

Sci Rep

2023 Mar 27

Kiran KK, Al-Osta MA, Ahmad S.

557. Visible-light induced degradation of diphenyl urea and polyethylene using polythiophene decorated CuFe(2)O(4) nanohybrids.

Sci Rep

2023 Mar 27

Riaz U, Gaffar S, Hauser K

558. Emergence of an erythroid cell-specific regulatory region in ABO intron 1 attributable to A- or B-antigen expression on erythrocytes in Hominoidea.

Sci Rep

2023 Mar 27

Sano R, Fukuda H, Kubo R

559. Comparative genome and phylogenetic analysis revealed the complex mitochondrial genome and phylogenetic position of Conopomorpha sinensis Bradley.

Sci Rep

2023 Mar 27

Chang H, Guo J, Li M

560. Artificial intelligence reveals dysregulation of osteosarcoma and cuproptosis-related biomarkers, PDHA1, CDKN2A and neutrophils.

Sci Rep

2023 Mar 26

Jiang J, Zhan X, Wei J

561. Differentiated extracts from freshwater and terrestrial mollusks inhibit virulence factor production in Cryptococcus neoformans.

Sci Rep

2023 Mar 26

Gutierrez-Gongora D, Raouf-Alkadhimi F, Prosser RS

562. Prognostic nomogram and risk factors for predicting survival in patients with pT2N0M0 esophageal squamous carcinoma.

Sci Rep

2023 Mar 26

Kang M, Wang Y, Yang M

563. Epigenetic modification of gene expression in cancer cells by terahertz demethylation.

Sci Rep

2023 Mar 26

Cheon H, Hur JK, Hwang W

564. Supervised deep learning-based paradigm to screen the enhanced oil recovery scenarios.

Sci Rep

2023 Mar 25

Kumar Pandey R, Gandomkar A, Vaferi B

565. Different molecular pathways are disrupted in Pyoderma gangrenosum patients and are associated with the severity of the disease.

Sci Rep

2023 Mar 25

Moura RR(#), Brandão L(#), Moltrasio C(#)

566. Non-destructive high-throughput measurement of elastic-viscous properties of maize using a novel ultra-micro sensor array and numerical validation.

Sci Rep

2023 Mar 25

Nakashima T, Tomobe H, Morigaki T

567. Increasing the melting temperature of VHH with the in silico free energy score.

Sci Rep

2023 Mar 25

Tomimoto Y, Yamazaki R, Shirai H.

568. Accurate clinical toxicity prediction using multi-task deep neural nets and contrastive molecular explanations.

Sci Rep

2023 Mar 25

Sharma B, Chenthamarakshan V, Dhurandhar A

Explainable machine learning for molecular toxicity prediction is a promising approach for efficient drug development and chemical safety. A predictive ML model of toxicity can reduce experimental cost and time while mitigating ethical concerns by significantly reducing animal and clinical testing. Herein, we use a deep learning framework for simultaneously modeling in vitro, in vivo, and clinical toxicity data. Two different molecular input representations are used; Morgan fingerprints and pre-trained SMILES embeddings. A multi-task deep learning model accurately predicts toxicity for all endpoints, including clinical, as indicated by the area under the Receiver Operator Characteristic curve and balanced accuracy. In particular, pre-trained molecular SMILES embeddings as input to the multi-task model improved clinical toxicity predictions compared to existing models in MoleculeNet benchmark. Additionally, our multitask approach is comprehensive in the sense that it is comparable to state-of-the-art approaches for specific endpoints in in vitro, in vivo and clinical platforms. Through both the multi-task model and transfer learning, we were able to indicate the minimal need of in vivo data for clinical toxicity predictions. To provide confidence and explain the model's predictions, we adapt a post-hoc contrastive explanation method that returns pertinent positive and negative features, which correspond well to known mutagenic and reactive toxicophores, such as unsubstituted bonded heteroatoms, aromatic amines, and Michael receptors. Furthermore, toxicophore recovery by pertinent feature analysis captures more of the in vitro (53%) and in vivo (56%), rather than of the clinical (8%), endpoints, and indeed uncovers a preference in known toxicophore data towards in vitro and in vivo experimental data. To our knowledge, this is the first contrastive explanation, using both present and absent substructures, for predictions of clinical and in vivo molecular toxicity.

569. Design of high gain base station antenna array for mm-wave cellular communication systems.

Sci Rep

2023 Mar 25

Sehrai DA, Khan J, Abdullah M

570. Steroid hormone levels and bone mineral density in women over 65 years of age.

Sci Rep

2023 Mar 25

Nunes E, Gallardo E, Morgado-Nunes S

571. Revealing the diversity of internal body temperature and panting response for feedlot cattle under environmental thermal stress.

Sci Rep

2023 Mar 25

Islam MA, Lomax S, Doughty AK

572. Temporal visitation patterns of points of interest in cities on a planetary scale: a network science and machine learning approach.

Sci Rep

2023 Mar 25

Betancourt F(#), Riascos AP(#), Mateos JL(#).

573. Utility of novel echocardiographic measurements to improve prenatal diagnosis of coarctation of the aorta.

Sci Rep

2023 Mar 25

Fujisaki T, Ishii Y, Takahashi K

574. Essential oil composition and antimicrobial potential of aromatic plants grown in the mid-hill conditions of the Western Himalayas.

Sci Rep

2023 Mar 25

Rathore S, Mukhia S, Kumar R

Essential oils are highly concentrated natural extracts obtained from plants, rich in bioactive constituents with antimicrobial properties, but the distinctive climate of the Western Himalayan region influences the same. Aromatic and medicinal plants, viz., Origanum majorana, Origanum vulgare, Cymbopogon winterianus, Pelargonium graveolens, and Nepeta cataria were grown in the foothills of the Western Himalayan condition and evaluated for essential oil content, composition, and their effect on some of the most common pathogenic microorganisms. The essential oil content (%) was 0.77, 0.45, 1.37, 0.15 and 0.17% in O. majorana, O. vulgare, C. winterianus, P. graveolens, and N. cataria, respectively. The major essential oil constituents of the isolated oils were terpinen-4-ol, thymol, citronellal, citronellol, and nepetalactone, contributing 41.24%, 31.81%, 43.13%, 43.35% and 91.43% in O. majorana, O. vulgare, C. winterianus, P. graveolens, and N. cataria, respectively. Well-diffusion assay revealed that the essential oil of O. majorana and O. vulgare was active against both the tested Gram-positive, viz., Bacillus subtilis MTCC 121, Micrococcus luteus MTCC 2470, and Staphylococcus aureus MTCC 96; and Gram-negative, viz., Escherichia coli MTCC 43, Klebsiella pneumoniae MTCC 109, and Pseudomonas aeruginosa MTCC 2453 bacteria, while the essential oil of C. winterianus, P. graveolens, and N. cataria showed activity against only some Gram-positive bacteria. Minimum inhibitory concentration (v/v) values indicated the highest efficacy of O. majorana essential oil against B. subtilis (0.5%), M. luteus (1%), and S. aureus (1%), while O. vulgare was most efficient to E. coli (2%) and K. pneumoniae (2%). C. winterianus essential oil did not inhibit any bacterial strains. M. luteus was susceptible to the essential oil of P. graveolens (1%) and N. cataria (0.5%) at low concentrations. Present findings showed the association between the chemical constituents' profile of isolated essential oils from the Himalayan region and their antimicrobial activity, indicating their perspective to be utilized as antibacterial means.

575. The oncogenic properties of the EWSR1::CREM fusion gene are associated with polyamine metabolism.

Sci Rep

2023 Mar 25

Kaprio H, Siddiqui A, Saustila L

576. A prospective cohort study assessing the relationship between long-COVID symptom incidence in COVID-19 patients and COVID-19 vaccination.

Sci Rep

2023 Mar 25

Abu Hamdh B, Nazzal Z.

577. Comparative transcriptome analysis reveals the phosphate starvation alleviation mechanism of phosphate accumulating Pseudomonas putida in Arabidopsis thaliana.

Sci Rep

2023 Mar 25

Srivastava S, Ranjan M, Bano N

578. Exploring differences in symptomatic adverse events assessment between nurses and physicians in the clinical trial setting.

Sci Rep

2023 Mar 25

Liu L, Liu Z, Ma C

579. A laminar forced convection via transport of water-copper-aluminum hybrid nanofluid through heated deep and shallow cavity with Corcione model.

Sci Rep

2023 Mar 25

Memon AA, Memon MA, Fenta A.

580. Effect of ambient wind on the performance of alpine downhill skier.

Sci Rep

2023 Mar 25

Li B, Li P, Zhang Y

581. Prenatal nicotine exposure alters gene expression profiles of neurons in the sub-regions of the VTA during early postnatal development.

Sci Rep

2023 Mar 25

McGill LD, Avci NG, Kazemi T

582. Effect of foraminal enlargement on microcrack formation and apical transportation: a nano-CT assessment.

Sci Rep

2023 Mar 25

Pinto JC, de Faria-Vasconcelos K, Leite AF

583. The acceleration effect of pump as turbine system during starting period.

Sci Rep

2023 Mar 25

Zhang YL, Li JF, Zhu ZC.

584. Phosphate induces inflammation and exacerbates injury from cigarette smoke in the bronchial epithelium.

Sci Rep

2023 Mar 25

Bollenbecker S, Heitman K, Czaya B

585. A common variant rs2054564 in ADAMST17 is associated with susceptibility to lumbar spondylosis.

Sci Rep

2023 Mar 25

Taniguchi Y, Akune T, Nishida N

586. Electrospun nanofibers of cellulose acetate/metal organic framework-third generation PAMAM dendrimer for the removal of methylene blue from aqueous media.

Sci Rep

2023 Mar 25

Heidari Y, Noroozian E, Maghsoudi S.

587. Lymphocyte to monocyte ratio predicts survival and is epigenetically linked to miR-222-3p and miR-26b-5p in diffuse large B cell lymphoma.

Sci Rep

2023 Mar 25

Metwally AM, Kasem AAHM, Youssif MI

588. Probing the Cr(3+) luminescence sensitization in β-Ga(2)O(3) with ion-beam-induced luminescence and thermoluminescence.

Sci Rep

2023 Mar 25

Esteves DM, Rodrigues AL, Alves LC

589. Thermal optima of cercarial emergence in trematodes from a marine high-temperature ecosystem, the Persian Gulf.

Sci Rep

2023 Mar 25

Khosravi M, Díaz-Morales DM, Thieltges DW

590. Sedentary lifestyle with increased risk of obesity in urban adult academic professionals: an epidemiological study in West Bengal, India.

Sci Rep

2023 Mar 25

Ghosh S, Paul M, Mondal KK

591. Assessing the combined toxic effects of metaldehyde mollucide.

Sci Rep

2023 Mar 25

Macar O, Kalefetoğlu Macar T, Çavuşoğlu K

592. Myosin light chain of shark fast skeletal muscle exhibits intrinsic urea-resistibility.

Sci Rep

2023 Mar 25

Kanoh S, Noma T, Ito H

593. Recruit-aged adults may preferentially weight task goals over deleterious cost functions during short duration loaded and imposed gait tasks.

Sci Rep

2023 Mar 25

Krajewski KT, Johnson CC, Ahamed NU

594. Experimental study on strength and failure characteristics of sandstone rock mass with complex cataclastic structure using 3D printing models.

Sci Rep

2023 Mar 25

Dong S, Lu Z, Hu X.

595. Fate of the capping agent of biologically produced gold nanoparticles and adsorption of enzymes onto their surface.

Sci Rep

2023 Mar 25

Pourali P, Dzmitruk V, Pátek M

Enzymotherapy based on DNase I or RNase A has often been suggested as an optional strategy for cancer treatment. The efficacy of such procedures is limited e.g. by a short half-time of the enzymes or a low rate of their internalization. The use of nanoparticles, such as gold nanoparticles (AuNPs), helps to overcome these limits. Specifically, biologically produced AuNPs represent an interesting variant here due to naturally occurring capping agents (CA) on their surface. The composition of the CA depends on the producing microorganism. CAs are responsible for the stabilization of the nanoparticles, and promote the direct linking of targeting and therapeutic molecules. This study provided proof of enzyme adsorption onto gold nanoparticles and digestion efficacy of AuNPs-adsorbed enzymes. We employed Fusarium oxysporum extract to produce AuNPs. These nanoparticles were round or polygonal with a size of about 5 nm, negative surface charge of about - 33 mV, and maximum absorption peak at 530 nm. After the adsorption of DNAse I, RNase A, or Proteinase K onto the AuNPs surface, the nanoparticles exhibited shifts in surface charge (values between - 22 and - 13 mV) and maximum absorption peak (values between 513 and 534 nm). The ability of AuNP-enzyme complexes to digest different targets was compared to enzymes alone. We found a remarkable degradation of ssDNA, and dsDNA by AuNP-DNAse I, and a modest degradation of ssRNA by AuNP-RNase A. The presence of particular enzymes on the AuNP surface was proved by liquid chromatography-mass spectrometry (LC-MS). Using SDS-PAGE electrophoresis, we detected a remarkable digestion of collagen type I and fibrinogen by AuNP-proteinase K complexes. We concluded that the biologically produced AuNPs directly bound DNase I, RNase A, and proteinase K while preserving their ability to digest specific targets. Therefore, according to our results, AuNPs can be used as effective enzyme carriers and the AuNP-enzyme conjugates can be effective tools for enzymotherapy.

596. Traffic monitoring system design considering multi-hazard disaster risks.

Sci Rep

2023 Mar 25

Gazzea M(#), Miraki A(#), Alisan O

597. Rutin alleviates colon lesions and regulates gut microbiota in diabetic mice.

Sci Rep

2023 Mar 25

Cai C(#), Cheng W(#), Shi T

598. Cooperative and conformist behavioural preferences predict the dual dimensions of political ideology.

Sci Rep

2023 Mar 25

Claessens S, Sibley CG, Chaudhuri A

599. Characterization of human oxidoreductases involved in aldehyde odorant metabolism.

Sci Rep

2023 Mar 25

Boichot V, Menetrier F, Saliou JM

600. Unexpected morphological variability in the eggshells of the South American caimans Caiman latirostris and Caiman yacare.

Sci Rep

2023 Mar 25

Hechenleitner EM, Fernandez Blanco MV, Núñez-Campero SR

601. Young generations' hopelessness perpetuates long-term conflicts.

Sci Rep

2023 Mar 25

Hasler BS, Leshem OA, Hasson Y

602. Imaging and micro-invasive analyses of black stains on the passepartout of Codex Atlanticus Folio 843 by Leonardo da Vinci.

Sci Rep

2023 Mar 25

Guarnieri N, Ghirardello M, Goidanich S

603. Molecular mapping and characterization of QTLs for grain quality traits in a RIL population of US rice under high nighttime temperature stress.

Sci Rep

2023 Mar 25

Kumar A, Thomas J(#), Gill N(#)

Elevated nighttime temperatures resulting from climate change significantly impact the rice crop worldwide. The rice (Oryza sativa L.) plant is highly sensitive to high nighttime temperature (HNT) during grain-filling (reproductive stage). HNT stress negatively affects grain quality traits and has a major impact on the value of the harvested rice crop. In addition, along with grain dimensions determining rice grain market classes, the grain appearance and quality traits determine the rice grain market value. During the last few years, there has been a major concern for rice growers and the rice industry over the prevalence of rice grains opacity and the reduction of grain dimensions affected by HNT stress. Hence, the improvement of heat-stress tolerance to maintain grain quality of the rice crop under HNT stress will bolster future rice value in the market. In this study, 185 F12-recombinant inbred lines (RILs) derived from two US rice cultivars, Cypress (HNT-tolerant) and LaGrue (HNT-sensitive) were screened for the grain quality traits grain length (GL), grain width (GW), and percent chalkiness (%chalk) under control and HNT stress conditions and evaluated to identify the genomic regions associated with the grain quality traits. In total, there were 15 QTLs identified; 6 QTLs represented under control condition explaining 3.33% to 8.27% of the phenotypic variation, with additive effects ranging from - 0.99 to 0.0267 on six chromosomes and 9 QTLs represented under HNT stress elucidating 6.39 to 51.53% of the phenotypic variation, with additive effects ranging from - 8.8 to 0.028 on nine chromosomes for GL, GW, and % chalk. These 15 QTLs were further characterized and scanned for natural genetic variation in a japonica diversity panel (JDP) to identify candidate genes for GL, GW, and %chalk. We found 6160 high impact single nucleotide polymorphisms (SNPs) characterized as such depending on their type, region, functional class, position, and proximity to the gene and/or gene features, and 149 differentially expressed genes (DEGs) in the 51 Mbp genomic region comprising of the 15 QTLs. Out of which, 11 potential candidate genes showed high impact SNP associations. Therefore, the analysis of the mapped QTLs and their genetic dissection in the US grown Japonica rice genotypes at genomic and transcriptomic levels provide deep insights into genetic variation beneficial to rice breeders and geneticists for understanding the mechanisms related to grain quality under heat stress in rice.

604. Distribution and association of interpregnancy weight change with subsequent pregnancy outcomes in Asian women.

Sci Rep

2023 Mar 24

Ku CW, Cheng TS, Ku CO

605. Tunable magnetic anisotropy of antiferromagnetic NiO in (Fe)/NiO/MgO/Cr/MgO(001) epitaxial multilayers.

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2023 Mar 24

Janus W, Ślęzak T, Ślęzak M

606. Plasma bioactive adrenomedullin predicts outcome after acute stroke in early rehabilitation.

Sci Rep

2023 Mar 24

Shafieesabet A, Jauert N, Hartmann O

An early and reliable prediction of outcomes after stroke is important for early effective stroke management and the adequate optimal planning of post-stroke rehabilitation and long-term care. Bioactive adrenomedullin (bio-ADM) is a 52-amino acid peptide that is an important peptide hormone in nervous system diseases. The aim of this study was to investigate the prognostic value of bio-ADM on outcomes after rehabilitation in patients with stroke. A total of 557 consecutive patients with a primary diagnosis of ischemic or hemorrhagic stroke (age 69.6-12.9 years, male 51.3%, ischemic stroke 72.5%), who were admitted to an in-patient early rehabilitation center directly after discharge from acute stroke hospital care, were enrolled in this prospective observational study. Plasma concentrations of bio-ADM were determined by using a chemiluminescence immunoassay (functional assay sensitivity 8 pg/ml). The early rehabilitation barthel index (ERBI) was used for the neurological assessment of the patients. The plasma bio-ADM level was analyzed in association with 6-month all-cause mortality as well as a composite outcome of all-cause mortality, unscheduled re-hospitalization, or transfer to a long-term care facility in a vegetative or minimally conscious state. Bio-ADM levels significantly increased in patients with ischemic stroke who died compared to surviving patients (40.4 pg/ml vs. 23.8 pg/ml, p < 0.001) or in those with composite outcomes compared to those with no events (36.9 pg/ml vs. 23.5 pg/ml, p < 0.001). Six-month all-cause mortality was higher in all patients with bio-ADM levels > 70 pg/ml (HR 4.83 [CI 2.28-10.2]). Patients with bio-ADM levels > 70 pg/ml also had higher rates of 6-month composite outcomes (HR 3.82 [CI 2.08-7.01]). Bio-ADM was an independent predictor of all-cause mortality and 6-month composite outcomes after adjusting for age, gender, and ERBI (adjusted OR 1.5; 95% CI 1.0-2.1; p = 0.047 and adjusted OR 1.48; 95% CI 1.1-2.0; p = 0.01, respectively). Bio-ADM may be a suitable novel biomarker to assess the outcomes of patients in rehabilitation after acute stroke. Elevated bio-ADM concentrations may have prognostic value for fatal and nonfatal events in patients with ischemic stroke during early rehabilitation.

607. Phase separation of α-crystallin-GFP protein and its implication in cataract disease.

Sci Rep

2023 Mar 24

Shi J(#), Zhu YX(#), Huang RY(#)

608. Diffuse and concentrated nitrogen sewage pollution in island environments with differing treatment systems.

Sci Rep

2023 Mar 24

Alldred FC, Gröcke DR, Leung CY

609. Full-color micro-LED display with photo-patternable and highly ambient-stable perovskite quantum dot/siloxane composite as color conversion layers.

Sci Rep

2023 Mar 24

Shim HC(#), Kim J(#), Park SY(#)

610. Bounded Wang tilings with integer programming and graph-based heuristics.

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2023 Mar 24

Tyburec M, Zeman J.

611. The effect of dapagliflozin on uric acid excretion and serum uric acid level in advanced CKD.

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2023 Mar 24

Iwata Y, Notsu S, Kawamura Y

612. Clinical significance of serum levels of 14-3-3β protein in patients with stable chronic obstructive pulmonary disease.

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2023 Mar 24

Wang D(#), Rao L(#), Lei H

613. Habitat quality influences trade-offs in animal movement along the exploration-exploitation continuum.

Sci Rep

2023 Mar 24

Smith JB, Keiter DA, Sweeney SJ

614. Experimental and theoretical studies for corrosion of molybdenum electrode using streptomycin drug in phosphoric acid medium.

Sci Rep

2023 Mar 24

Medany SS, Ahmad YH, Fekry AM.

615. A near real-time web-system for predicting fire spread across the Cerrado biome.

Sci Rep

2023 Mar 24

Oliveira U, Soares-Filho B, Rodrigues H

616. Reconfigurable magnon interference by on-chip dynamic wavelength conversion.

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2023 Mar 24

Sarker MS, Yao L, Yamahara H

617. Exploring alternative insecticide delivery options in a "lethal house lure" for malaria vector control.

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2023 Mar 24

Oumbouke WA, Barreaux AMG, Zran IT

618. A new, rare, small-ranged, and endangered mountain snake of the genus Elaphe from the Southern Levant.

Sci Rep

2023 Mar 24

Jablonski D, Ribeiro-Júnior MA, Simonov E

The genus Elaphe Fitzinger, 1833 includes 17 species of charismatic, large-sized, non-venomous, Eurasian snakes. In the Western Palearctic, the genus is represented by three species from the Elaphe quatuorlineata group ranging from the Apennine peninsula to Central Asia. The southernmost population of this group is distributed in the mountains of the Southern Levant, with more than 400 km gap to other Elaphe populations. This population has been known to science for only 50 years and is virtually unstudied due to its extreme rarity. We studied these snakes' morphological and genetic variation from the three countries where they are known to occur, i.e., Israel (Hermon, the Israeli-controlled Golan Heights), Lebanon, and Syria. We used nine mitochondrial and nuclear genes, complete mitogenome sequences, and a comprehensive morphological examination including published data, our own field observations, and museum specimens, to study its relationship to other species in the group. The three currently recognized species of the group (E. quatuorlineata, E. sauromates, E. urartica), and the Levant population, form four deeply divergent, strongly supported clades. Three of these clades correspond to the abovementioned species while the Southern Levant clade, which is genetically and morphologically distinct from all named congeners, is described here as a new species, Elaphe druzei sp. nov. The basal divergence of this group is estimated to be the Late Miocene with subsequent radiation from 5.1 to 3.9 Mya. The revealed biogeography of the E. quatuorlineata group supports the importance of the Levant as a major center of endemism and diversity of biota in Eurasia. The new species is large-sized and is one of the rarest snakes in the Western Palearctic. Because of its small mountain distribution range, in an area affected by land use and climate change, the new Elaphe urgently needs strict protection. Despite political issues, we hope this will be based on the cooperation of all countries where the new species occurs.

619. Revealing hazard-exposure heterophily as a latent characteristic of community resilience in social-spatial networks.

Sci Rep

2023 Mar 24

Liu CF, Mostafavi A.

620. Partner separation rescues pair bond-induced decreases in hypothalamic oxytocin neural densities.

Sci Rep

2023 Mar 24

Fricker BA, Roshko VC, Jiang J

621. Laguncularia racemosa leaves indicate the presence of potentially toxic elements in mangroves.

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2023 Mar 24

Pimentel Victório C, Silva Dos Santos M, Cordeiro Dias A

622. Magnetic anchor technique assisted laparoscopic cholecystectomy in swine.

Sci Rep

2023 Mar 24

Zhang M(#), Ma J(#), Gai J

623. Predicting prostate cancer in men with PSA levels of 4-10 ng/mL: MRI-based radiomics can help junior radiologists improve the diagnostic performance.

Sci Rep

2023 Mar 24

Zhong JG, Shi L, Liu J

624. Application of the electrical resistivity tomography in groundwater detection on loess plateau.

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2023 Mar 24

Wu J, Dai F, Liu P

Agricultural irrigation of the South Jingyang tableland in Shaanxi Province, China has led to a continuous rise of the groundwater level and has triggered a series of loess landslides, thereby seriously affecting the life and property safety of local residents. Research shows that the major cause of the landslide in the loess layer of the South Jingyang tableland is the rising groundwater level. Therefore, the research on the formation mechanism of landslide in this area should include the investigation of the stratigraphic structure and groundwater level distribution characteristics. On this basis, a series of approaches, such as electrical resistivity tomography (ERT), borehole, and laboratory tests, was carried out on the South Jingyang tableland, and the groundwater level distribution and stratigraphic structure in the study area were determined. The qualitative relationship between resistivity value and water content at different depths was detected using the inversion results of ERT and borehole data. Through laboratory tests, the quantitative relationship between resistivity values under different water contents was established. The precise depth of the groundwater level was inferred by connecting the qualitative relationship with the quantitative relationship, and then a detailed 3D geological model was established by linking the inversion results of ERT with the field borehole lithology data and geological survey data. The detection results show that when the qualitative and quantitative analyses of the ERT inversion results were combined, the distribution of the groundwater level was accurately judged. The ERT is effective in reflecting the stratigraphic structure and hydrological characteristics of the Loess Plateau, and its potential as a supplementary technology for detecting the groundwater level is reasonable. This study addresses the limitation and inaccuracy in determining the stratum structure and groundwater level by solely relying on borehole information or ERT. The established 3D geological model not only provides a basis for the study of groundwater table fluctuation, but also a technical guidance for the stability evaluation of loess slope, landslide prediction, and early warning in the study area.

625. Prediction of global potential suitable habitats of Nicotiana alata Link et Otto based on MaxEnt model.

Sci Rep

2023 Mar 24

Zhang YF, Chen ST, Gao Y

626. Tracheoesophageal fistula treated with magnetic compression technique in canines.

Sci Rep

2023 Mar 24

Li Y(#), Zhang M(#), Liu P

627. Evaluation of aerosols in a simulated orthodontic debanding procedure.

Sci Rep

2023 Mar 24

Pratt A(#), Eckermann N(#), Venugopalan SR

628. Evolution process and failure mechanism of a large expressway roadside landslide.

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2023 Mar 24

Zhang J, Zhang S, Ding Y

629. A population-based nomogram to individualize treatment modality for pancreatic cancer patients underlying surgery.

Sci Rep

2023 Mar 24

Shi XY, Wang Y, Zhou X

630. Efficient CO(2) methanation using nickel nanoparticles supported mesoporous carbon nitride catalysts.

Sci Rep

2023 Mar 24

Refaat Z, Saied ME, Naga AOAE

631. Extracellular vesicle-associated microRNA signatures related to lymphovascular invasion in early-stage lung adenocarcinoma.

Sci Rep

2023 Mar 24

Shimada Y, Yoshioka Y, Kudo Y

632. First evidence of the link between internal and external structure of the human inner ear otolith system using 3D morphometric modeling.

Sci Rep

2023 Mar 24

Smith CM, Curthoys IS, Laitman JT.

633. Astrocytes actively support long-range molecular clock synchronization of segregated neuronal populations.

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2023 Mar 24

Giantomasi L, Ribeiro JF, Barca-Mayo O

634. Different impacts of TP53 mutations on cell cycle-related gene expression among cancer types.

Sci Rep

2023 Mar 24

Sasaki K, Takahashi S, Ouchi K

635. Analysis of gadolinium oxide using microwave-enhanced fiber-coupled micro-laser-induced breakdown spectroscopy.

Sci Rep

2023 Mar 24

Ikeda Y, Soriano JK, Ohba H

636. Evidence for cultural differences in affect during mother-infant interactions.

Sci Rep

2023 Mar 24

Abu Salih M(#), Abargil M(#), Badarneh S

637. An imperfect spectrum sensing-based multi-hop clustering routing protocol for cognitive radio sensor networks.

Sci Rep

2023 Mar 24

Wang J, Liu C.

638. Methanol electro oxidation on Ni-Pt-CrO/CNFs composite: morphology, structural, and electrochemical characterization.

Sci Rep

2023 Mar 24

Abdel-Hady EE, Gamal A, Hamdy H

639. Development of a comfort suit-type soft-wearable robot with flexible artificial muscles for walking assistance.

Sci Rep

2023 Mar 24

Piao J, Kim M, Kim J

640. Social support enhances the mediating effect of psychological resilience on the relationship between life satisfaction and depressive symptom severity.

Sci Rep

2023 Mar 24

Chang YH, Yang CT, Hsieh S.

641. Recurrent activity in neuronal avalanches.

Sci Rep

2023 Mar 24

Salners T, Avila KE, Nicholson B

642. In vitro hair follicle growth model for drug testing.

Sci Rep

2023 Mar 24

Kageyama T, Miyata H, Seo J

643. Confocal LiDAR for remote high-resolution imaging of auto-fluorescence in aquatic media.

Sci Rep

2023 Mar 23

Santos J, Rodrigo PJ, Petersen PM

644. MRI-based long-term follow-up of indolent orbital lymphomas after curative radiotherapy: imaging remission criteria and volumetric regression kinetics.

Sci Rep

2023 Mar 23

Hoffmann C, Mohr C, Johansson P

645. Differentiation of patient-specific void urine-derived human induced pluripotent stem cells to fibroblasts and skeletal muscle myocytes.

Sci Rep

2023 Mar 23

Kibschull M, Nguyen TTN, Chow T

646. Distance mapping and volumetric assessment of the ankle and syndesmotic joints in progressive collapsing foot deformity.

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2023 Mar 23

Dibbern K, Vivtcharenko V, Salomao Barbachan Mansur N

647. Novel flexible and conformable composite neutron scintillator based on fully enriched lithium tetraborate.

Sci Rep

2023 Mar 23

Pino F, Delgado JC, Carturan SM

648. An effective technique for developing the graphical polynomials of certain molecular graphs.

Sci Rep

2023 Mar 23

Masmali I, Nadeem M, Yousaf A

649. A hierarchical dynamic Bayesian learning network for EMG-based early prediction of voluntary movement intention.

Sci Rep

2023 Mar 23

Chen Y, Zhang H, Wang C

Decoding human action intention prior to motion onset with surface electromyograms (sEMG) is an emerging neuroengineering topic with interesting clinical applications such as intelligent control of powered prosthesis/exoskeleton devices. Despite extensive prior works in the related fields, it remains a technical challenge due to considerable variability of complex multi-muscle activation patterns in terms of volatile spatio-temporal characteristics. To address this issue, we first hypothesize that the inherent variability of the idle state immediately preceding the motion initiation needs to be addressed explicitly. We therefore design a hierarchical dynamic Bayesian learning network model that integrates an array of Gaussian mixture model - hidden Markov models (GMM-HMMs), where each GMM-HMM learns the multi-sEMG processes either during the idle state, or during the motion initiation phase of a particular motion task. To test the hypothesis and evaluate the new learning network, we design and build a upper-limb sEMG-joystick motion study system, and collect data from 11 healthy volunteers. The data collection protocol adapted from the psychomotor vigilance task includes repeated and randomized binary hand motion tasks (push or pull) starting from either of two designated idle states: relaxed (with minimal muscle tones), or prepared (with muscle tones). We run a series of cross-validation tests to examine the performance of the method in comparison with the conventional techniques. The results suggest that the idle state recognition favors the dynamic Bayesian model over a static classification model. The results also show a statistically significant improvement in motion prediction accuracy by the proposed method (93.83±6.41%) in comparison with the conventional GMM-HMM method (89.71±8.98%) that does not explicitly account for the idle state. Moreover, we examine the progress of prediction accuracy over the course of motion initiation and identify the important hidden states that warrant future research.

650. A comparative analysis of human and AI performance in forensic estimation of physical attributes.

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2023 Mar 23

Barrington S(#), Farid H(#).

651. A universal model for the Lorenz curve with novel applications for datasets containing zeros and/or exhibiting extreme inequality.

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2023 Mar 23

Sitthiyot T, Holasut K.

652. Classification of monthly tidal envelopes in mixed tide regimes.

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2023 Mar 23

Byun DS, Hart DE, Kim S

653. Characterization of radiation-resistance mechanism in Spirosoma montaniterrae DY10(T) in terms of transcriptional regulatory system.

Sci Rep

2023 Mar 23

Cho C, Lee D, Jeong D

654. The effect of rope jumping training on the dynamic balance ability and hitting stability among adolescent tennis players.

Sci Rep

2023 Mar 23

Shi Z, Xuan S, Deng Y

To discuss the effects of 12 weeks of jump rope training on dynamic balance and stroke stability in junior tennis players. Sixteen junior tennis players at CTN7 level were used as subjects and randomly divided equally into ExG and ConG for 12 weeks of training, 3 times a week. The ExG performed Jump Rope training and Special Preparation Activity (JR + SPA), the ConG performed only Special Preparation Activity (SPA) to ensure that the training intensity was basically the same. The Biodex Balance System (BBS) was applied to examine the participants' dynamic balance ability, including the Limits of Stability (LOS) and the Single Leg Stability Test (SLST), the International Tennis Number (ITN) tests ball striking stability. Experimental data were statistically analyzed using independent samples t test, paired samples t test, and repeated measures ANOVA test. We observed significant (P < 0.05) differences in limits of stability (LOS) before and after the test in subjects in the ExG and significant (P < 0.05) differences in ODC, BDC, RDC, FLDC, BLDC, and BRDC metrics in the ExG, and a 2 (group: ExG, ConG) × 2 (time: 0w, 12w) repeated measures ANOVA was performed and found significant (P < 0.05) differences in LDC, RDC, FLDC, BLDC, BRDC, and LOST (S) indexes interacted significantly (P < 0.01) in single-leg stability test (SLST) pre- and post-measures were found in subjects in ExG and in MLSI (L) in ExG (P < 0.05), and 2 (group: ExG, ConG) × 2 (time: 0w, 12w) repeated measures ANOVAs were performed and found that OSI (L), MLSI (L), OSI (R), MLSI (R) interaction on indicators was significant (P < 0.05). The difference in hitting stability between subjects in ExG was significant (P < 0.01) at the pre and post test, while the difference in ConG was significant (P < 0.01) at the pre and post test only on the hitting stability test (depth). 2 (Group: ExG, ConG) × 2 (Time: 0w, 12w) repeated measures ANOVA was performed and found a significant interaction between the two (P < 0.01). We suggest to incorporate Forward double-legged alternating jump rope, Reverse double-legged alternating jump rope, Double-legged alternating cross jump rope, Squatting alternating single-legged jump rope into the regular tennis training course with special techniques, which will help the junior tennis players' dynamic balance ability and hitting stability, and can effectively improve the competitive level of junior tennis players.

655. Image analysis of cutaneous melanoma histology: a systematic review and meta-analysis.

Sci Rep

2023 Mar 23

Clarke EL, Wade RG, Magee D

The current subjective histopathological assessment of cutaneous melanoma is challenging. The application of image analysis algorithms to histological images may facilitate improvements in workflow and prognostication. To date, several individual algorithms applied to melanoma histological images have been reported with variations in approach and reported accuracies. Histological digital images can be created using a camera mounted on a light microscope, or through whole slide image (WSI) generation using a whole slide scanner. Before any such tool could be integrated into clinical workflow, the accuracy of the technology should be carefully evaluated and summarised. Therefore, the objective of this review was to evaluate the accuracy of existing image analysis algorithms applied to digital histological images of cutaneous melanoma. Database searching of PubMed and Embase from inception to 11th March 2022 was conducted alongside citation checking and examining reports from organisations. All studies reporting accuracy of any image analysis applied to histological images of cutaneous melanoma, were included. The reference standard was any histological assessment of haematoxylin and eosin-stained slides and/or immunohistochemical staining. Citations were independently deduplicated and screened by two review authors and disagreements were resolved through discussion. The data was extracted concerning study demographics; type of image analysis; type of reference standard; conditions included and test statistics to construct 2 × 2 tables. Data was extracted in accordance with our protocol and the Preferred Reporting Items for Systematic Reviews and Meta-Analyses-Diagnostic Test Accuracy (PRISMA-DTA) Statement. A bivariate random-effects meta-analysis was used to estimate summary sensitivities and specificities with 95% confidence intervals (CI). Assessment of methodological quality was conducted using a tailored version of the Quality Assessment of Diagnostic Accuracy Studies (QUADAS-2) tool. The primary outcome was the pooled sensitivity and specificity of image analysis applied to cutaneous melanoma histological images. Sixteen studies were included in the systematic review, representing 4,888 specimens. Six studies were included in the meta-analysis. The mean sensitivity and specificity of automated image analysis algorithms applied to melanoma histological images was 90% (CI 82%, 95%) and 92% (CI 79%, 97%), respectively. Based on limited and heterogeneous data, image analysis appears to offer high accuracy when applied to histological images of cutaneous melanoma. However, given the early exploratory nature of these studies, further development work is necessary to improve their performance.

656. Synthesis of Ag(3)PO(4)/Ag(4)P(2)O(7) by microwave-hydrothermal method for enhanced UV-visible photocatalytic performance.

Sci Rep

2023 Mar 23

Promnopas S, Promnopas W, Maisang W

657. Effect of grassland cutting frequency, species mixture, wilting and fermentation pattern of grass silages on in vitro methane yield.

Sci Rep

2023 Mar 23

Weiby KV, Krizsan SJ, Dønnem I

658. A realized facilitation cascade mediated by biological soil crusts in a sagebrush steppe community.

Sci Rep

2023 Mar 23

Ridenour WM, Lortie CJ, Callaway RM.

659. Structural finite element model updating considering soil-structure interaction using ls-dyna in loop.

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2023 Mar 23

Park G, Jung J, Yoon H.

660. Heat shock protein A2 is a novel extracellular vesicle-associated protein.

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2023 Mar 23

Sojka DR(#), Abramowicz A(#), Adamiec-Organiściok M

661. Eye-movement indices of arousal predict ADHD and comorbid externalizing symptoms over a 2-year period.

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2023 Mar 23

Kleberg JL, Frick MA, Brocki KC.

662. Water cycle changes in reanalyses: a complementary framework.

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2023 Mar 23

Vargas Godoy MR, Markonis Y.

663. Predicting choice behaviour in economic games using gaze data encoded as scanpath images.

Sci Rep

2023 Mar 23

Byrne SA, Reynolds APF, Biliotti C

664. Shortening the sulfur cell cycle by a green approach for bio-production of extracellular metalloid-sulfide nanoparticles.

Sci Rep

2023 Mar 23

Asghari-Paskiabi F, Imani M, Rafii-Tabar H

665. Associations of physical activity domains and muscle strength exercise with non-alcoholic fatty liver disease: a nation-wide cohort study.

Sci Rep

2023 Mar 23

Park Y(#), Sinn DH(#), Kim K

666. Impact of reactivity controlled compression ignition (RCCI) mode engine operation in diesel engine powered with B20 blend of waste cooking oil biodiesel.

Sci Rep

2023 Mar 23

Anish M, Jayaprabakar J, Bency P

667. The inhibitive action of 2-mercaptobenzothiazole on the porosity of corrosion film formed on aluminum and aluminum-titanium alloys in hydrochloric acid solution.

Sci Rep

2023 Mar 23

El-Sayed AR, El-Hendawy MM, El-Mahdy MS

2-Mercaptobenzothiazole (2-MBT) in a solution of 0.5 M HCl is an effective corrosion inhibitor for aluminum and aluminum-titanium alloys. Tafel polarization and electrochemical impedance spectroscopy (EIS) were employed to assess this heterocyclic compound's anticorrosive potential and complementary by scanning electron microscope (SEM) and calculating porosity percentage in the absence and presence of various inhibitor concentrations. Inhibition efficiency (IE%) was strongly related to concentration (10-6-10-3 M). Temperature's effect on corrosion behavior was investigated. The data exhibited that the IE% decreases as the temperature increases. An increase in activation energy (Ea) with increasing the inhibitor concentration and the decrease in the IE% value of the mentioned compound with raising the temperature indicates that the inhibitor molecules are adsorbed physically on the surface. Thermodynamic activation parameters for Al and Al-Ti alloy dissolution in both 0.5 M HCl and the inhibited solution were calculated and discussed. According to Langmuir's adsorption isotherm, the inhibitor molecules were adsorbed. The evaluated standard values of the enthalpy ([Formula: see text], entropy ([Formula: see text] and free energy changes ([Formula: see text] showed that [Formula: see text] and [Formula: see text] are negative, while [Formula: see text] was positive. The formation of a protective layer adsorbed on the surfaces of the substrates was confirmed with the surface analysis (SEM). The porosity percentage is significantly reduced in the inhibitor presence and gradually decreased with increasing concentration. Furthermore, the density functional theory (DFT) and Monte Carlo (MC) simulations were employed to explain the variance in protecting the Al surface from corrosion. Interestingly, the theoretical findings align with their experimental counterparts. The planarity of 2-MBT and the presence of heteroatoms are the playmakers in the adsorption process.

668. Estradiol-mediated protection against high-fat diet induced anxiety and obesity is associated with changes in the gut microbiota in female mice.

Sci Rep

2023 Mar 23

Acharya KD(#), Graham M(#), Raman H

669. Development of the multi-directional ablation process using the femtosecond laser to create a pattern on the lateral side of a 3D microstructure.

Sci Rep

2023 Mar 23

Ha CW, Son Y.

670. Contribution of the leaf and silique photosynthesis to the seeds yield and quality of oilseed rape (Brassica napus L.) in reproductive stage.

Sci Rep

2023 Mar 23

Wang C, Yang J, Chen W

Influences of photosynthesis of leaf and silique on seeds yield and quality of oilseed rape (Brassica napus L.) were explored in this study. A field comparing experiment with several rapeseed varieties was conducted and the results showed, that the leaf area index (LAI), silique surface area index (SAI), siliques number per plant, and biological yield were statistically classified as the first principal factors which greatly influenced seeds yield, the leaf net photosynthetic rate (Pn) and silique Pn were the second principal factors; the stomatal conductance (Gs) and chlorophyll a (Chl a) content were the first principal factors which influenced leaf Pn and silique Pn. A shading experiment was conducted and the results showed that, under treatments of the ZH1, ZH2, and ZH3 (shading rapeseed plants during flowering stage, during time from initial flowering until seeds ripening, and during time from flowering ending until seeds ripening, respectively), respectively the seeds yield per plant was reduced by 34.6%, 84.3%, and 86.1%, the seed protein content was significantly increased. The treatment ZH1 Not, but the ZH2 and ZH3 caused significant decrease in both seed oil content and oleic acid (C18:1) content in seed oil, and the contents of linoleic acid (C18:2), linolenic acid (C18:3) in oil were significantly increased, gene expression of the ACCase (Acetyl-CoA carboxylase), FAD2 (fatty acid desaturase), and FAD3 (ω-3 fatty acid dehydrogenase) in green seeds was restrained/changed. Thus the LAI, SAI, siliques number per plant, biological yield per plant, leaf Pn, silique Pn, and the Gs, Chl a content of leaf and silique formed an indexes system to be used in screening rapeseed variety with higher light efficiency and seeds yield; the silique photosynthesis inhibition and the photosynthates deficiency in rapeseed plant after flowering stage predominately influenced seeds yield and quality.

671. A polygenic and family risk score are both independently associated with risk of type 2 diabetes in a population-based study.

Sci Rep

2023 Mar 23

Duschek E, Forer L, Schönherr S

672. Seasonal dependent suitability of physical parameterizations to simulate precipitation over the Himalayan headwater.

Sci Rep

2023 Mar 23

Dixit A, Sahany S, Mishra SK

The Himalayan ecosystem is fragile and needs robust management strategies for sustainability of natural resources such as water and vegetation. Therefore, reliable precipitation estimation becomes quite important from operational and regulation standpoints. It is crucial for numerous activities including policy/planning, agriculture, reservoir operations, disaster management, and others. In addition, reliable information on temporal variability of precipitation is also crucial for various applications such as agricultural and hydrological. The western Himalaya receives two distinct weather systems during summer and winter. Summer is responsible (largely) for rainfall and winter is for snowfall. Therefore, we hypothesize that there may not be a single set of parameterization schemes that can represent well both the weather systems. To investigate, we set up the WRF modeling system and performed six experiments with a combination of three microphysics (MP3, MP3, and WSM6) and two cumulus schemes (KF, and BMJ). It was found that the precipitation along the Himalayan foothills (near to basin terminal) is underestimated in four out of six experiments. Only experiments with BMJ cumulus scheme along with WSM6 and MP8 microphysics were able to show a considerable amount of precipitation along these foothills. It was noted that all six experiments showed high precipitation in the upstream region and over the mountain peaks and ridges in North-Western Himalaya. For DJF, each experiment was found to have large biases and none of them represented the observation with high confidence. However, the selection of observation reference data itself is a challenging task because of data paucity in this region. Therefore, the closest experiment to the most appropriate observation was selected as the reliable configuration (MP8_KF: MP8 microphysics and KF cumulus scheme) for DJF precipitation simulation. In this study we have, for the first time, reported the role of seasonal sensitivity for the climate scale simulations as we found that different schemes were suitable for different weather systems.

673. Longitudinal changes in disgust sensitivity during pregnancy and the early postpartum period, and the role of recent health problems.

Sci Rep

2023 Mar 23

Dlouhá D, Roberts SC, Hlaváčová J

674. Occupation as a risk factor of small cell lung cancer.

Sci Rep

2023 Mar 23

García TC, Ruano-Ravina A, Candal-Pedreira C

675. Diversity and structure of feather mite communities on seabirds from the north-east Atlantic and Mediterranean Sea.

Sci Rep

2023 Mar 23

Stefan LM, Isbert W, Gómez-Díaz E

676. Optical investigation and computational modelling of BaTiO(3) for optoelectronic devices applications.

Sci Rep

2023 Mar 23

Elmahgary MG, Mahran AM, Ganoub M

677. Unmasking pipefish otolith using synchrotron-based scanning X-ray fluorescence.

Sci Rep

2023 Mar 23

Haÿ V, Berland S, Medjoubi K

678. Evaluation of a point-of-care haemozoin assay (Gazelle device) for rapid detection of Plasmodium knowlesi malaria.

Sci Rep

2023 Mar 23

Tan AF, Thota P, Sakam SSB

679. Satureja khuzistanica Jamzad essential oil and pure carvacrol attenuate TBI-induced inflammation and apoptosis via NF-κB and caspase-3 regulation in the male rat brain.

Sci Rep

2023 Mar 23

Abbasloo E, Amiresmaili S, Shirazpour S

Traumatic brain injury (TBI) causes progressive dysfunction that induces biochemical and metabolic changes that lead to cell death. Nevertheless, there is no definitive FDA-approved therapy for TBI treatment. Our previous immunohistochemical results indicated that the cost-effective natural Iranian medicine, Satureja khuzistanica Jamzad essential oil (SKEO), which consists of 94.16% carvacrol (CAR), has beneficial effects such as reducing neuronal death and inflammatory markers, as well as activating astrocytes and improving neurological outcomes. However, the molecular mechanisms of these neuroprotective effects have not yet been elucidated. This study investigated the possible mechanisms involved in the anti-inflammatory and anti-apoptotic properties of SKEO and CAR after TBI induction. Eighty-four male Wistar rats were randomly divided into six groups: Sham, TBI, TBI + Vehicle, TBI + CAR (100 and 200 mg/kg), and TBI + SKEO (200 mg/kg) groups. After establishing the "Marmarou" weight drop model, diffuse TBI was induced in the rat brain. Thirty minutes after TBI induction, SKEO & CAR were intraperitoneally injected. One day after TBI, injured rats exhibited significant brain edema, neurobehavioral dysfunctions, and neuronal apoptosis. Western blot results revealed upregulation of the levels of cleaved caspase-3, NFκB p65, and Bax/Bcl-2 ratio, which was attenuated by CAR and SKEO (200 mg/kg). Furthermore, the ELISA results showed that CAR treatment markedly prevents the overproduction of the brain pro-inflammatory cytokines, including IL-1β, TNF-α, and IL-6. Moreover, the neuron-specific enolase (NSE) immunohistochemistry results revealed the protective effect of CAR and SKEO on post-TBI neuronal death. The current study revealed that the possible neuroprotective mechanisms of SKEO and CAR might be related to (at least in part) modulating NF-κB regulated inflammation and caspase-3 protein expression. It also suggested that CAR exerts more potent protective effects than SKEO against TBI. Nevertheless, the administration of SKEO and CAR may express a novel therapeutic approach to ameliorate TBI-related secondary phase neuropathological outcomes.

680. Clinical variations of polypoidal choroidal vasculopathy: A cohort study from Japan and the USA.

Sci Rep

2023 Mar 23

Fukuyama H, BouGhanem G, Moir J

681. Deciphering timing and rates of Central German Chernozem/Phaeozem formation through high resolution single-grain luminescence dating.

Sci Rep

2023 Mar 23

von Suchodoletz H, van Meer M, Kühn P

682. Machine learning at the edge for AI-enabled multiplexed pathogen detection.

Sci Rep

2023 Mar 23

Ganjalizadeh V, Meena GG, Stott MA

683. Advancing neutron diffraction for accurate structural measurement of light elements at megabar pressures.

Sci Rep

2023 Mar 23

Haberl B, Guthrie M, Boehler R.

684. Investigating livestock management in the early Neolithic archaeological site of Cabecicos Negros (Almería, Spain) from the organic residue analysis in pottery.

Sci Rep

2023 Mar 23

Tarifa-Mateo N, Saña M, Clop X

685. Assessing the development of mental fatigue during simulated flights with concurrent EEG-fNIRS measurement.

Sci Rep

2023 Mar 23

Hamann A, Carstengerdes N.

686. Quantifying progress in research topics across nations.

Sci Rep

2023 Mar 23

Asatani K, Oki S, Momma T

687. Inter- and intra-rater reliability of new application software for computerised paediatric version of Wisconsin Gait Scale.

Sci Rep

2023 Mar 23

Guzik A, Wolan-Nieroda A, Drużbicki M.

The paediatric version of Wisconsin Gait Scale (WGS) is a reliable tool for gait assessment in children with spastic hemiplegic cerebral palsy (CP). We decided to develop a solution which will make it possible to objectify the descriptive paediatric version of the WGS, and which, consequently, will allow researchers/clinicians to more easily perform accurate assessment of gait patterns in patients. The aim of the study was to assess inter- and intra-rater reliability of new application software for computerised paediatric version of the WGS in children with hemiplegic CP. The study involved 31 children with hemiplegic CP. The app was designed using a model based on thematic categories of the paediatric WGS, and utilising auxiliary lines between specific points on the patient's body, and taking into account angular values, duration and length of the specific gait phases, in order to enable acquisition of quantitative data corresponding to the components of the WGS. The gait of the study participants was recorded, in series of videos. These provided material for three independent raters who reviewed the recordings twice and assessed the participants' gait using the app. After the evaluation was completed, the data were retrieved from the software. The new application software for the computerised paediatric WGS presents very good inter- and intra-rater reliability. Intra-class correlation coefficient (ICC) was very high in measurement 1 (ICC > 0.9) and 2 (ICC > 0.8), which reflects a very high degree of agreement between the three examiners; there was also high agreement for the specific examiners, between the two measurements (ICC > 0.9). The observational gait scale, objectified through the new software, and enabling computer-aided use of the paediatric WGS, presents practical advantages for examiners since it facilitates decisions taken in the process of WGS-based assessment in children with spastic hemiplegic CP.

688. Identification and gene expression analysis of serine proteases and their homologs in the Asian corn borer Ostrinia furnacalis.

Sci Rep

2023 Mar 23

Yang L, Xu X, Wei W

689. IgG1 and IgG4 antibodies sample initial structure dependent local conformational states and exhibit non-identical Fab dynamics.

Sci Rep

2023 Mar 23

Natesan R, Agrawal NJ.

690. Robot-assisted investigation of sensorimotor control in Parkinson's disease.

Sci Rep

2023 Mar 23

Tamilselvam YK, Jog M, Patel RV.

691. Music that is used while studying and music that is used for sleep share similar musical features, genres and subgroups.

Sci Rep

2023 Mar 23

Scarratt RJ, Heggli OA, Vuust P

692. Appropriate time to radical surgery for colorectal cancer patients complicated with newly onset cerebral infarction: a propensity score matching analysis.

Sci Rep

2023 Mar 23

Dou W(#), Liu T(#), Zheng H

693. Combining bird tracking data with high-resolution thermal mapping to identify microclimate refugia.

Sci Rep

2023 Mar 23

Ramos RF, Franco AMA, Gilroy JJ

694. Supply chain logistics with quantum and classical annealing algorithms.

Sci Rep

2023 Mar 23

Weinberg SJ, Sanches F, Ide T

695. The maternal brain is more flexible and responsive at rest: effective connectivity of the parental caregiving network in postpartum mothers.

Sci Rep

2023 Mar 23

Orchard ER, Voigt K, Chopra S

696. An improved hyperparameter optimization framework for AutoML systems using evolutionary algorithms.

Sci Rep

2023 Mar 23

Vincent AM, Jidesh P.

697. The perspectives of UK personnel towards current killing practices for laboratory rodents.

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2023 Mar 23

Clarkson JM, Leach MC, McKeegan DEF

698. Molecular simulations of SSTR2 dynamics and interaction with ligands.

Sci Rep

2023 Mar 23

Gervasoni S, Guccione C, Fanti V

699. High resolution propagation-based lung imaging at clinically relevant X-ray dose levels.

Sci Rep

2023 Mar 23

Albers J, Wagner WL, Fiedler MO

Absorption-based clinical computed tomography (CT) is the current imaging method of choice in the diagnosis of lung diseases. Many pulmonary diseases are affecting microscopic structures of the lung, such as terminal bronchi, alveolar spaces, sublobular blood vessels or the pulmonary interstitial tissue. As spatial resolution in CT is limited by the clinically acceptable applied X-ray dose, a comprehensive diagnosis of conditions such as interstitial lung disease, idiopathic pulmonary fibrosis or the characterization of small pulmonary nodules is limited and may require additional validation by invasive lung biopsies. Propagation-based imaging (PBI) is a phase sensitive X-ray imaging technique capable of reaching high spatial resolutions at relatively low applied radiation dose levels. In this publication, we present technical refinements of PBI for the characterization of different artificial lung pathologies, mimicking clinically relevant patterns in ventilated fresh porcine lungs in a human-scale chest phantom. The combination of a very large propagation distance of 10.7 m and a photon counting detector with [Formula: see text] pixel size enabled high resolution PBI CT with significantly improved dose efficiency, measured by thermoluminescence detectors. Image quality was directly compared with state-of-the-art clinical CT. PBI with increased propagation distance was found to provide improved image quality at the same or even lower X-ray dose levels than clinical CT. By combining PBI with iodine k-edge subtraction imaging we further demonstrate that, the high quality of the calculated iodine concentration maps might be a potential tool for the analysis of lung perfusion in great detail. Our results indicate PBI to be of great value for accurate diagnosis of lung disease in patients as it allows to depict pathological lesions non-invasively at high resolution in 3D. This will especially benefit patients at high risk of complications from invasive lung biopsies such as in the setting of suspected idiopathic pulmonary fibrosis (IPF).

700. Examining the impacts of DM filters to PFC isolated Ćuk converter for DCM operation by comparing Si and SiC MOSFET.

Sci Rep

2023 Mar 23

Şehirli E.

Examining impacts of differential mode (DM) filter topologies covering pi, LC with damping, LC, LCL filter through isolated Ćuk single phase PFC converter is realized in this paper regarding to power factor, THD and efficiency. Application of PFC isolated Ćuk converter is conducted with 42 kHz switching frequency and 50 W power. Each filter is modeled, designed, and applied experimentally via isolated PFC Ćuk converter. Average model derivation based on state-space, for DCM operation of input side inductor of isolated PFC Ćuk converter that is not introduced in literature is the main contribution of the paper. Second main contribution is to analyze filter types by linear methods for the transfer functions cascading the converter and filter transfer functions, which is not presented for PFC converters. It is also presented that solely LCL filter which is not analyzed for PFC converters in detail in literature, does not give desired results. So, increasing the effectivity of LCL filter, new filter structure LCL with parallel C filter is proposed and modeled in this paper. Thanks to the applications, presented results of LCL with parallel C filter is better than others with 4.9% current THD and '1' power factor. Proposed LCL filter ensures 45% reduction of total inductor value, comparing to LC filter. Besides, LCL with C filter provides better control characteristics with maximum allowable gain for stability as 0.7585 higher than other topologies. Moreover, practical design methodology of filter types avoiding complex mathematical procedure is given in this paper. Applications with each filters provide THD requirements, obtained 4.9% as a best value, lower than IEC61000-3-2 standard. Maximum percentage improvement comparing to the IEC61000-3-2 is 27.5% for third harmonic. Furthermore, SiC and Si Mosfets are employed separately in the converter and compared by using each DM filters regarding to power factor, THD, efficiency through applications. As a result, better efficiency with SiC Mosfet as 83% and better THD with Si Mosfet as 4.9% are conducted.

701. ADAR1 has an oncogenic function and can be a prognostic factor in cervical cancer.

Sci Rep

2023 Mar 23

Nakamura K, Shigeyasu K, Okamoto K

702. The risk assessment of rockburst intensity in the highway tunnel based on the variable fuzzy sets theory.

Sci Rep

2023 Mar 23

Wang AF, Yang XT, Gu XB.

703. Temperature dependence of electrical conductivity and variable hopping range mechanism on graphene oxide films.

Sci Rep

2023 Mar 23

Sánchez-Trujillo DJ(#), Osorio-Maldonado LV(#), Prías-Barragán JJ(#).

The rapid development of optoelectronic applications for optical-to-electrical conversion has increased the interest in graphene oxide material. Here, graphene oxide films (GOF) were used as source material in an infrared photodetector configuration and the temperature dependence of the electrical conductivity was studied. GOF were prepared by the double-thermal decomposition (DTD) method at 973 K, with a fixed carbonization temperature, in a pyrolysis system, under a controlled nitrogen atmosphere, over quartz substrates. Graphene oxide films were mechanically supported in a photodetector configuration on Bakelite substrates and electrically contacted with copper wires and high-purity silver paint. Morphological images from the GOF's surface were taken employing a scanning electron microscope and observed a homogeneous surface which favored the electrical contacts deposition. Vibrational characteristics were studied employing Raman spectroscopy and determined the typical graphene oxide bands. GOF were used to discuss the effect of temperature on the film's electrical conductivity. Current-voltage (I-V) curves were taken for several temperatures varying from 20 to 300 K and the electrical resistance values were obtained from 142.86 to 2.14 kΩ. The GOF electrical conductivity and bandgap energy (Eg) were calculated, and it was found that when increasing temperature, the electrical conductivity increased from 30.33 to 2023.97 S/m, similar to a semiconductor material, and Eg shows a nonlinear change from 0.33 to 0.12 eV, with the increasing temperature. Conduction mechanism was described mainly by three-dimensional variable range hopping (3D VRH). Additionally, measurements of voltage and electrical resistance, as a function of wavelength were considered, for a spectral range between 1300 and 3000 nm. It was evidenced that as the wavelength becomes longer, a greater number of free electrons are generated, which contributes to the electrical current. The external quantum efficiency (EQE) was determined for this proposed photodetector prototype, obtaining a value of 40%, similar to those reported for commercial semiconductor photodetectors. This study provides a groundwork for further development of graphene oxide films with high conductivity in large-scale preparation.

704. Functional sugar-free chewing gum infused with spices bolsters antioxidant capacity and phenolic content of saliva.

Sci Rep

2023 Mar 23

Crowe-White KM, Jung SE, Bragg A

705. Scar/WAVE has Rac GTPase-independent functions during cell wound repair.

Sci Rep

2023 Mar 23

Nakamura M, Hui J, Stjepić V

706. Biological interactions between micro swimmers and cross fluid with inclined MHD effects in a complex wavy canal.

Sci Rep

2023 Mar 22

Ayub A, Shah SZH, Asjad MI

707. An induced annual modulation signature in COSINE-100 data by DAMA/LIBRA's analysis method.

Sci Rep

2023 Mar 22

Adhikari G, Carlin N, Choi J

708. Aerosol-based functional nanocomposite coating process for large surface areas.

Sci Rep

2023 Mar 22

Lai S, Sublemontier O, Aubry E

709. Experiments and simulation of block motion in underwater bench blasting.

Sci Rep

2023 Mar 22

Wu L, Liang Z, Chen M.

710. Quantifying implicit biases in refereeing using NBA referees as a testbed.

Sci Rep

2023 Mar 22

Pelechrinis K.

711. Quasi-band structure of quantum-confined nanocrystals.

Sci Rep

2023 Mar 22

Buerkle M, Lozac'h M, Mariotti D

712. Spectrochemical approach combined with symptoms data to diagnose fibromyalgia through paper spray ionization mass spectrometry (PSI-MS) and multivariate classification.

Sci Rep

2023 Mar 22

Alves MVS, Maciel LIL, Passos JOS

This study performs a chemical investigation of blood plasma samples from patients with and without fibromyalgia, combined with some of the symptoms and their levels of intensity used in the diagnosis of this disease. The symptoms evaluated were: visual analogue pain scale (VAS); fibromyalgia impact questionnaire (FIQ); Hamilton anxiety rating scale (HAM); Tampa Scale for Kinesiophobia (TAMPA); quality of life Questionnaire-physical and mental health (QL); and Pain Catastrophizing Scale (CAT). Plasma samples were analyzed by paper spray ionization mass spectrometry (PSI-MS). Spectral data were organized into datasets and related to each of the symptoms measured. The datasets were submitted to multivariate classification using supervised models such as principal component analysis with linear discriminant analysis (PCA-LDA), successive projections algorithm with linear discriminant analysis (SPA-LDA), genetic algorithm with linear discriminant analysis (GA-LDA) and their versions with quadratic discriminant analysis (PCA/SPA/GA-QDA) and support vector machines (PCA/SPA/GA-SVM). These algorithm combinations were performed aiming the best class separation. Good discrimination between the controls and fibromyalgia samples were observed using PCA-LDA, where the spectral data associated with the CAT symptom achieved 100% classification sensitivity, and associated with the VAS symptom achieved 100% classification specificity, with both symptoms at the moderate level of intensity. The spectral variable at 579 m/z was found to be substantially significant for classification according to the PCA loadings. According to the human metabolites database, this variable can be associated with a LysoPC compound, which comprises a class of metabolites already evidenced in other studies for fibromyalgia diagnosis. This study proposed an investigation of spectral data combined with clinical data to compare the classification ability of different datasets. The good classification results obtained confirm this technique is as a good analytical tool for the detection of fibromyalgia, and provides theoretical support for other studies about fibromyalgia diagnosis.

713. Genome surveillance of SARS-CoV-2 variants and their role in pathogenesis focusing on second wave of COVID-19 in India.

Sci Rep

2023 Mar 22

Sarkar P, Banerjee S, Saha SA

714. Influence of Allee effect on the spatiotemporal behavior of a diffusive predator-prey model with Crowley-Martin type response function.

Sci Rep

2023 Mar 22

Guin LN, Pal PJ, Alzahrani J

715. Statin protects men but not women with HIV against loss of muscle mass, strength, and physical function: a pilot study.

Sci Rep

2023 Mar 22

Cárdenas JDG, Oliveira VHF, Borsari AL

Statins are cholesterol-lowering drugs commonly used among people with HIV, associated with an increased risk of myopathies. Considering that cardiovascular disease, statin therapy, and sarcopenia are independently prevalent in people with HIV, clarity on the potential benefits or harms of statin therapy on muscle health is useful to provide insight into ways to maximize skeletal muscle health and minimize CVD risk in this population. We aimed to study the effects of statin therapy on strength, muscle mass, and physical function parameters in people with HIV. This was a pilot cross-sectional study. People with HIV on continuous statin therapy (n = 52) were paired 1:1 according to age (people with HIV 53.9 ± 8.2 and people with HIV on statins 53.9 ± 8.4 years), sex, body mass index (Body mass index, people with HIV 28.6 ± 5.3 and people with HIV on statins 28.8 ± 6.3 kg/m2), and race with people with HIV not using statin (n = 52). Participants were evaluated for muscle strength (i.e. handgrip strength), lean and fat body mass (using bioelectric impedance analysis), and physical function (i.e. Short Physical Performance Battery-SPPB). Isokinetic strength and appendicular lean mass (using dual-energy X-ray absorptiometry), more accurate strength and body composition measures, were determined in 38% of the participants. Overall, statin usage does not exacerbated loss of muscle strength (32.2 ± 11.5 vs. 30.3 ± 9.6 kg, p > 0.05) muscle mass (7.6 ± 1.8 vs. 7.7 ± 1.1 kg/m2, p > 0.05), and impaired physical performance (10.1 ± 1.8 vs. 9.7 ± 2.1 points, p > 0.05) of PLWH. When analyzed by sex, men living with HIV on statins usage presented higher appendicular muscle mass (28.4 ± 3.1 vs. 26.2 ± 4.9 kg, p < 0.05) handgrip strength (42.1 ± 8.8 vs. 37.1 ± 8.3 kg, p < 0.05) and physical function through SPPB score (10.9 ± 1.3 vs. 9.5 ± 2.1, p < 0.05) than men living with HIV not on statins treatment. The same protection was not observed in women. This data was demonstrated when muscle mass and strength were determined clinically (i.e. handgrip strength and electrical impedance) and when more precise laboratory measurements of muscle mass and strength were conducted (i.e. isokinetic strength and DXA scans). Statin does not exacerbate muscle wasting, strength loss, or muscle dysfunction among people with HIV. Indeed, statins may protect men, but not woman with HIV against HIV and antiretroviral therapy-induced loss of muscle mass and strength.

716. Projecting XRP price burst by correlation tensor spectra of transaction networks.

Sci Rep

2023 Mar 22

Chakraborty A, Hatsuda T, Ikeda Y.

717. Quartile coefficient of variation is more robust than CV for traits calculated as a ratio.

Sci Rep

2023 Mar 22

Botta-Dukát Z.

718. Speech therapy to overcome dyslexia in primary schoolers.

Sci Rep

2023 Mar 22

Nurseitova Z, Shayakhmetova A.

719. CACNA1D overexpression and voltage-gated calcium channels in prostate cancer during androgen deprivation.

Sci Rep

2023 Mar 22

McKerr N, Mohd-Sarip A, Dorrian H

720. Comparative efficacy of a novel Bacillus subtilis-based probiotic and pharmacological zinc oxide on growth performance and gut responses in nursery pigs.

Sci Rep

2023 Mar 22

Sudan S, Fletcher L, Zhan X

721. Performance investigation of different headlights used in vehicles under foggy conditions.

Sci Rep

2023 Mar 22

Sefer T, Ayaz R, Ajder A

722. Feature-based interaction between masks and target in continuous flash suppression.

Sci Rep

2023 Mar 22

Drewes J(#), Witzel C, Zhu W(#).

723. Bioinformatics-based investigation on the genetic influence between SARS-CoV-2 infections and idiopathic pulmonary fibrosis (IPF) diseases, and drug repurposing.

Sci Rep

2023 Mar 22

Islam MA, Kibria MK, Hossen MB

Some recent studies showed that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections and idiopathic pulmonary fibrosis (IPF) disease might stimulate each other through the shared genes. Therefore, in this study, an attempt was made to explore common genomic biomarkers for SARS-CoV-2 infections and IPF disease highlighting their functions, pathways, regulators and associated drug molecules. At first, we identified 32 statistically significant common differentially expressed genes (cDEGs) between disease (SARS-CoV-2 and IPF) and control samples of RNA-Seq profiles by using a statistical r-package (edgeR). Then we detected 10 cDEGs (CXCR4, TNFAIP3, VCAM1, NLRP3, TNFAIP6, SELE, MX2, IRF4, UBD and CH25H) out of 32 as the common hub genes (cHubGs) by the protein-protein interaction (PPI) network analysis. The cHubGs regulatory network analysis detected few key TFs-proteins and miRNAs as the transcriptional and post-transcriptional regulators of cHubGs. The cDEGs-set enrichment analysis identified some crucial SARS-CoV-2 and IPF causing common molecular mechanisms including biological processes, molecular functions, cellular components and signaling pathways. Then, we suggested the cHubGs-guided top-ranked 10 candidate drug molecules (Tegobuvir, Nilotinib, Digoxin, Proscillaridin, Simeprevir, Sorafenib, Torin 2, Rapamycin, Vancomycin and Hesperidin) for the treatment against SARS-CoV-2 infections with IFP diseases as comorbidity. Finally, we investigated the resistance performance of our proposed drug molecules compare to the already published molecules, against the state-of-the-art alternatives publicly available top-ranked independent receptors by molecular docking analysis. Molecular docking results suggested that our proposed drug molecules would be more effective compare to the already published drug molecules. Thus, the findings of this study might be played a vital role for diagnosis and therapies of SARS-CoV-2 infections with IPF disease as comorbidity risk.

724. Inequality in time to first antenatal care visits and its predictors among pregnant women in India: an evidence from national family health survey.

Sci Rep

2023 Mar 22

Tripathy A, Mishra PS.

725. A genome-wide association study identifies a possible role for cannabinoid signalling in the pathogenesis of diabetic kidney disease.

Sci Rep

2023 Mar 22

Osman W(#), Mousa M(#), Albreiki M

Diabetic kidney disease (DKD), also known as diabetic nephropathy, is the leading cause of renal impairment and end-stage renal disease. Patients with diabetes are at risk for DKD because of poor control of their blood glucose, as well as nonmodifiable risk factors including age, ethnicity, and genetics. This genome-wide association study (GWAS) was conducted for the first time in the Emirati population to investigate possible genetic factors associated with the development and progression of DKD. We included data on 7,921,925 single nucleotide polymorphism (SNPs) in 258 cases of type 2 diabetes mellitus (T2DM) who developed DKD and 938 control subjects with T2DM who did not develop DKD. GWAS suggestive results (P < 1 × 10-5) were further replicated using summary statistics from three cohorts with T2DM-induced DKD (Bio Bank Japan data, UK Biobank, and FinnGen Project data) and T1DM-induced DKD (UK-ROI cohort data from Belfast, UK). When conducting a multiple linear regression model for gene-set analyses, the CNR2 gene demonstrated genome-wide significance at 1.46 × 10-6. SNPs in CNR2 gene, encodes cannabinoid receptor 2 or CB2, were replicated in Japanese samples with the leading SNP rs2501391 showing a Pcombined = 9.3 × 10-7, and odds ratio = 0.67 in association with DKD associated with T2DM, but not with T1DM, without any significant association with T2DM itself. The allele frequencies of our cohort and those of the replication cohorts were in most cases markedly different. In addition, we replicated the association between rs1564939 in the GLRA3 gene and DKD in T2DM (P = 0.016, odds ratio = 0.54 per allele C). Our findings suggest evidence that cannabinoid signalling may be involved in the development of DKD through CB2, which is expressed in different kidney regions and known to be involved in insulin resistance, inflammation, and the development of kidney fibrosis.

726. Effectiveness of high-flow nasal cannulae compared with noninvasive positive-pressure ventilation in preventing reintubation in patients receiving prolonged mechanical ventilation.

Sci Rep

2023 Mar 22

Tseng CW, Chao KY, Wu HL

Many intensive care unit patients who undergo endotracheal extubation experience extubation failure and require reintubation. Because of the high mortality rate associated with reintubation, postextubation respiratory management is crucial, especially for high-risk populations. We conducted the present study to compare the effectiveness of oxygen therapy administered using high-flow nasal cannulae (HFNC) and noninvasive positive pressure ventilation (NIPPV) in preventing reintubation among patients receiving prolonged mechanical ventilation (PMV). This single-center, prospective, unblinded randomized controlled trial was at the respiratory care center (RCC). Participants were randomized to an HFNC group or an NIPPV group (20 patients in each) and received noninvasive respiratory support (NRS) administered using their assigned method. The primary outcome was reintubation within7 days after extubation. None of the patients in the NIPPV group required reintubation, whereas 5 (25%) of the patients in the HFNC group required reintubation (P = 0.047). The 90-day mortality rates of the NIPPV and HFNC groups (four patients [20%] vs. two patients [10%], respectively) did not differ significantly. No significant differences in length of RCC stay, length of hospital stay, time to liberation from NRS, and ventilator-free days at 28-day were identified. The time to event outcome analysis also revealed that the risk of reintubation in the HFNC group was higher than that in the NIPPV group (P = 0.018). Although HFNC is becoming increasingly common as a form of postextubation NRS, HFNC may not be as effective as NIPPV in preventing reintubation among patients who have been receiving PMV for at least 2 weeks. Additional studies evaluating HFNC as an alternative to NIPPV for patients receiving PMV are warranted.ClinicalTrial.gov ID: NCT04564859; IRB number: 20160901R.Trial registration: ClinicalTrial.gov ( https://clinicaltrials.gov/ct2/show/NCT04564859 ).

727. Innovative metal oxides (CaO, SrO, MgO) impregnated waste-derived activated carbon for biohydrogen purification.

Sci Rep

2023 Mar 22

Koo-Amornpattana W, Phadungbut P, Kunthakudee N

728. Binding and inactivation of human coronaviruses, including SARS-CoV-2, onto purified clinoptilolite-tuff.

Sci Rep

2023 Mar 22

Nizet S(#), Rieger J(#), Sarabi A

729. Study on the defect reduction of metal folding on the formed tooth top with finishing roller in gear rolling process.

Sci Rep

2023 Mar 22

Fu X, Chen P, Wang J

730. Light scattering in stacked mesophyll cells results in similarity characteristic of solar spectral reflectance and transmittance of natural leaves.

Sci Rep

2023 Mar 22

Xu K, Ye H.

731. A novel 3D culture model for human primary mammary adipocytes to study their metabolic crosstalk with breast cancer in lean and obese conditions.

Sci Rep

2023 Mar 22

Rebeaud M(#), Bouche C(#), Dauvillier S

732. Evaluation of biometric formulas in the calculation of intraocular lens according to axial length and type of the lens.

Sci Rep

2023 Mar 22

Sánchez-Liñan N(#), Pérez-Rueda A(#), Parrón-Carreño T(#)

733. Carbon nanotubes as a nitric oxide nano-reservoir improved the controlled release profile in 3D printed biodegradable vascular grafts.

Sci Rep

2023 Mar 22

Kabirian F, Baatsen P, Smet M

734. Enhancing a SARS-CoV-2 nucleocapsid antigen test sensitivity with cost efficient strategy through a cotton intermembrane insertion.

Sci Rep

2023 Mar 22

Nicollete DRP, Benedetti R, Valença BA

735. Characterization and investigation of electrochemical and biological properties of antibacterial silver nanoparticle-deposited TiO(2) nanotube array surfaces.

Sci Rep

2023 Mar 22

Durdu S, Yalçin E, Altinkök A

736. In vitro antiviral effect of ethanolic extracts from Azadirachta indica and Melia azedarach against goat lentivirus in colostrum and milk.

Sci Rep

2023 Mar 22

de Sousa ALM, Rizaldo Pinheiro R, Furtado Araujo J

737. NTSR1 glycosylation and MMP dependent cleavage generate three distinct forms of the protein.

Sci Rep

2023 Mar 22

Libanje F, Delille R, Young PA

738. The effect of herbicides on morphological features of pollen grains in Prunus serotina Ehrh. in the context of elimination of this invasive species from European forests.

Sci Rep

2023 Mar 22

Wrońska-Pilarek D, Maciejewska-Rutkowska I, Lechowicz K

739. Offloading operation bivariate extreme response statistics for FPSO vessel.

Sci Rep

2023 Mar 22

Gaidai O, Cao Y, Xu X

740. The ethyl acetate extract of Wenxia Changfu Formula inhibits the carcinogenesis of lung adenocarcinoma by regulating PI3K-AKT signaling pathway.

Sci Rep

2023 Mar 22

Wang L(#), Han X(#), Li H

741. Prenatal environment impacts telomere length in newborn dairy heifers.

Sci Rep

2023 Mar 22

Meesters M, Van Eetvelde M, Martens DS

742. Three-dimensional visualization of neural networks inside bone by Osteo-DISCO protocol and alteration of bone remodeling by surgical nerve ablation.

Sci Rep

2023 Mar 22

Utagawa K(#), Shin T(#), Yamada H(#)

743. Vitamin B12 supplementation and health behavior of Austrian vegans: a cross-sectional online survey.

Sci Rep

2023 Mar 22

Fuschlberger M, Putz P.

The number of vegans is increasing and was estimated at 2.0% of the Austrian population. Austrian vegans were found to have lower intakes and levels of vitamin B12 compared to vegetarians and omnivores. Vegans are advised to consume reliable sources of vitamin B12, e.g., in the form of dietary supplements or fortified foods. This study aimed to investigate health and supplementation behavior, with special emphasis on the supplementation of vitamin B12, and to demographically characterize the community of Austrian adult vegans. A nonrandom, voluntary sample of adult vegans with a principal residence in Austria was recruited with an online cross-sectional survey via social media and messenger platforms. Associations between respondent characteristics (gender, education, nutritional advice by a dietitian or nutritionist) and health/supplementation behaviors were examined by cross-tabulation. The questionnaire was completed by 1565 vegans (completion rate 88%), of whom 86% were female, the median age was 29 years, 6% were obese, and 49% had completed an academic education. Ninety-two percent consumed vitamin B12 through supplements and/or fortified foods, and 76% had their vitamin B12 status checked. The prevalence of vitamin B12 intake through supplements and/or fortified foods was slightly (not statistically significant) higher among women vs. men (93% vs. 89%), those who were academically educated vs. those who were not (93% vs. 91%), and those who had taken nutritional advice vs. those who had not (97% vs. 92%). Professional nutritional advice had been taken by only 9.5% of female and 8.4% of male respondents. Those who had taken advice reported a lower smoking prevalence (p = 0.05, φ = 0.05), higher prevalence of checking vitamin B12 status (p < 0.01, φ = 0.10), vit B12 intake through supplements and/or fortified foods (p = 0.03, φ = 0.05), and taking supplements of omega-3 (p < 0.01, φ = 0.14), selenium (p = 0.02, φ = 0.06), and iodine (p = 0.02, φ = 0.06). Austrian vegans can be characterized as predominantly young, female, urban, highly educated, and nonobese. The rate of vitamin B12 intake through supplements and/or fortified foods is fairly high (92%), but should be further improved e.g., by increasing the share of vegans who follow professional nutritional advice (requiring a diploma in dietetics, nutritional science, or medicine in Austria).

744. Mouse strain-dependent variation in metabolic associated fatty liver disease (MAFLD): a comprehensive resource tool for pre-clinical studies.

Sci Rep

2023 Mar 22

Karimkhanloo H, Keenan SN, Bayliss J

745. AMMI-Bayesian perspective in the selection of pre-cultivars of carioca beans in Agreste-Sertão of Pernambuco, Brazil.

Sci Rep

2023 Mar 22

de Melo GG, de Oliveira LA, da Silva CP

746. Reduced bimolecular charge recombination in efficient organic solar cells comprising non-fullerene acceptors.

Sci Rep

2023 Mar 22

Wu Y, Li Y, van der Zee B

747. Sex-differences in prostaglandin signaling: a semi-systematic review and characterization of PTGDS expression in human sensory neurons.

Sci Rep

2023 Mar 22

Shen BQ, Sankaranarayanan I, Price TJ

There is increasing evidence of sex differences in underlying mechanisms causing pain in preclinical models, and in clinical populations. There are also important disconnects between clinical pain populations and the way preclinical pain studies are conducted. For instance, osteoarthritis pain more frequently affects women, but most preclinical studies have been conducted using males in animal models. The most widely used painkillers, nonsteroidal anti-inflammatory drugs (NSAIDs), act on the prostaglandin pathway by inhibiting cyclooxygenase (COX) enzymes. The purpose of this study was to analyze the preclinical and clinical literature on the role of prostaglandins and COX in inflammation and pain. We aimed to specifically identify studies that used both sexes and investigate whether any sex-differences in the action of prostaglandins and COX inhibition had been reported, either in clinical or preclinical studies. We conducted a PubMed search and identified 369 preclinical studies and 100 clinical studies that matched our inclusion/exclusion criteria. Our analysis shows that only 17% of preclinical studies on prostaglandins used both sexes and, out of those, only 19% analyzed or reported data separated by sex. In contrast, 79% of the clinical studies analyzed used both sexes. However, only 6% of those reported data separated by sex. Interestingly, 14 out of 15 preclinical studies and 5 out of 6 clinical studies that analyzed data separated by sex have identified sex-differences. This builds on the increasing evidence of sex-differences in prostaglandin signaling and the importance of sex as a biological variable in data analysis. The preclinical literature identifies a sex difference in prostaglandin D2 synthase (PTGDS) expression where it is higher in female than in male rodents in the nervous system. We experimentally validated that PTGDS expression is higher in female human dorsal root ganglia (DRG) neurons recovered from organ donors. Our semi-systematic literature review reveals a need for continued inclusivity of both male and female animals in prostaglandins studies and data analysis separated by sex in preclinical and clinical studies. Our finding of sex-differences in neuronal PTGDS expression in humans exemplifies the need for a more comprehensive understanding of how the prostaglandin system functions in the DRG in rodents and humans.

748. Distributed dynamic strain sensing of very long period and long period events on telecom fiber-optic cables at Vulcano, Italy.

Sci Rep

2023 Mar 21

Currenti G, Allegra M, Cannavò F

749. DeepGeni: deep generalized interpretable autoencoder elucidates gut microbiota for better cancer immunotherapy.

Sci Rep

2023 Mar 21

Oh M, Zhang L.

750. Enhancing bio-oil yield extracted from Egyptian castor seeds by using microwave and ultrasonic.

Sci Rep

2023 Mar 21

Khater EG, Abd Allah SA, Bahnasawy AH

Energy scarcity and conventional energy problems are the main reason of finding a renewable source of energy which is cheap and environmental friendly, therefore, biodiesel production is one of the most promising solutions of this problem. Also, Egyptian castor is one of the most important crops for oil production compared with other commonly used oil crops. The main aim of this study is to enhance the production of bio-oil from Egyptian castor seeds by using microwave and ultrasonic as pre-treatments. To achieve that, the effects of extraction screw speed (20, 40 and 60 rpm) and temperature (100, 150, 200 and 250 °C) on oil extraction yield and quality, extraction energy requirements and extraction time and were studied. Also, the effect of pretreatment conditions of microwave at three levels of power (Low, Med and High) and different times (1, 2 and 3 min) and pretreatment condition ultrasonic with different temperatures (40, 60 and 80 °C) and different times (15, 30 and 45 min) for castor seeds before extraction with the optimum condition of the screw press on oil extraction yield from castor seeds, extraction energy, extraction time and quality of the oil extracted. The results indicate that the optimum conditions oil extraction by screw press were 200 °C extraction temperature and 60 rpm screw speed. It could be seen that the extraction oil yield, extraction energy requirements and extraction time were 35.59%, 18.68 and 1.86 min, respectively. Microwave pretreatments had better on oil yield and energy required for extraction compared to ultrasonic pretreatments, where, microwave pretreatments recorded high oil yield and lower energy requirements compared to the ultrasonic pretreatments. Oil yield ranged from 32.67 to 37.41% compared to 13.29 to 39.83% in literature. The time required for extraction was ranged from 1.77 to 2.00 and 1.79 to 2.21 min for microwave and ultrasonic pretreatments, respectively. The pretreatment improved properties of the extracted oil.

751. Acute antagonism in three-drug combinations for vaginal HIV prevention in humanized mice.

Sci Rep

2023 Mar 21

Gallay PA, Ramirez CM, Baum MM.

752. Optimization of a high-throughput nanofluidic real-time PCR to detect and quantify of 15 bacterial species and 92 Streptococcus pneumoniae serotypes.

Sci Rep

2023 Mar 21

Downs SL, Madhi SA, van der Merwe L

753. One year follow-up on a randomized study investigating serratus anterior muscle and pectoral nerves type I block to reduced neuropathic pain descriptors after mastectomy.

Sci Rep

2023 Mar 21

Flores EM(#), Gouveia FV(#), Matsumoto M(#)

Breast cancer is the second most common diagnosed type of cancer in women. Chronic neuropathic pain after mastectomy occurs frequently and is a serious health problem. In our previous single-center, prospective, randomized controlled clinical study, we demonstrated that the combination of serratus anterior plane block (SAM) and pectoral nerve block type I (PECS I) with general anesthesia reduced acute postoperative pain. The present report describes a prospective follow-up study of this published study to investigate the development of chronic neuropathic pain 12 months after mastectomy by comparing the use of general anesthesia alone and general anesthesia with SAM + PECS I. Additionally, the use of analgesic medication, quality of life, depressive symptoms, and possible correlations between plasma levels of interleukin (IL)-1 beta, IL-6, and IL-10 collected before and 24 h after surgery as predictors of pain and depression were evaluated. The results showed that the use of SAM + PECS I with general anesthesia reduced numbness, hypoesthesia to touch, the incidence of patients with chronic pain in other body regions and depressive symptoms, however, did not significantly reduce the incidence of chronic neuropathic pain after mastectomy. Additionally, there was no difference in the consumption of analgesic medication and quality of life. Furthermore, no correlation was observed between IL-1 beta, IL-6, and IL-10 levels and pain and depression. The combination of general anesthesia with SAM + PECS I reduced the occurrence of specific neuropathic pain descriptors and depressive symptoms. These results could promote the use of SAM + PECS I blocks for the prevention of specific neuropathic pain symptoms after mastectomy.Registration of clinical trial: The Research Ethics Board of the Hospital Sirio-Libanes/Brazil approved the study (CAAE 48721715.0.0000.5461). This study is registered at Registro Brasileiro de Ensaios Clinicos (ReBEC), and ClinicalTrials.gov, Identifier: NCT02647385.

754. Utilization of optimized microwave sintering to produce safe and sustainable one-part alkali-activated materials.

Sci Rep

2023 Mar 21

Refaat M, Mohsen A, Nasr EAR

755. Novel intranasal vaccine targeting SARS-CoV-2 receptor binding domain to mucosal microfold cells and adjuvanted with TLR3 agonist Riboxxim™ elicits strong antibody and T-cell responses in mice.

Sci Rep

2023 Mar 21

Horvath D, Temperton N, Mayora-Neto M

756. Dose optimization in surgical prophylaxis: sub-inhibitory dosing of vancomycin increases rates of biofilm formation and the rates of surgical site infection.

Sci Rep

2023 Mar 21

Brothers KM, Parker DM, Taguchi M

Antibiotic stewardship is viewed as having great public health benefit with limited direct benefit to the patient at the time of administration. The objective of our study was to determine if inappropriate administration of antibiotics could create conditions that would increase the rates of surgical infection. We hypothesized that sub-MIC levels of vancomycin would increase Staphylococcus aureus growth, biofilm formation, and rates of infection. S. aureus MRSA and MSSA strains were used for all experiments. Bacteria were grown planktonically and monitored using spectrophotometry. Quantitative agar culture was used to measure planktonic and biofilm bacterial burden. A mouse abscess model was used to confirm phenotypes in vivo. In the planktonic growth assay, increases in bacterial burden at ¼ MIC vancomycin were observed in USA300 JE2 by 72 h. Similar findings were observed with ½ MIC in Newman and SH1000. For biofilm formation, USA300 JE2 at ¼ and ½ MIC vancomycin increased biofilm formation by approximately 1.3- and 2.3-fold respectively at 72 h as compared to untreated controls. Similar findings were observed with Newman and SH1000 with a 2.4-fold increase in biofilm formation at ½ MIC vancomycin. In a mouse abscess model, there was a 1.2-fold increase with sub-MIC vancomycin at 3 days post infection. Our study showed that Sub-optimal vancomycin dosing promoted S. aureus planktonic growth and biofilm formation, phenotypic measures of bacterial virulence. This phenotype induced by sub-MIC levels of vancomycin was also observed to increase rates of infection and pathogenesis in our mouse model. Risks of exposure to sub-MIC concentrations with vancomycin in surgical procedures are greater as there is decreased bioavailability in tissue in comparison to other antibiotics. This highlights the importance of proper antibiotic selection, stewardship, and dosing for both surgical prophylaxis and treatment of infection.

757. The secure judgment of graphic similarity against malicious adversaries and its applications.

Sci Rep

2023 Mar 21

Liu X, Xu Y, Luo D

758. Acoustic micronektonic distribution and density is structured by macroscale oceanographic processes across 17-48° N latitudes in the North Atlantic Ocean.

Sci Rep

2023 Mar 21

García-Seoane E, Klevjer T, Mork KA

759. Expression of olfactory receptor genes in non-olfactory tissues in the developing and adult zebrafish.

Sci Rep

2023 Mar 21

Jundi D(#), Coutanceau JP(#), Bullier E

760. Hypothermia is an independent risk factor for prolonged ICU stay in coronary artery bypass surgery: an observational study.

Sci Rep

2023 Mar 21

Wang YC, Huang HH, Lin PC

761. Role of triggering receptor expressed on myeloid cells-1 in the mechanotransduction signaling pathways that link low shear stress with inflammation.

Sci Rep

2023 Mar 21

Liu M(#), Panagopoulos AN(#), Oguz UM(#)

762. Responsive fungal insoles for pressure detection.

Sci Rep

2023 Mar 21

Nikolaidou A, Phillips N, Tsompanas MA

763. Effect of heat treatment atmospheres on microstructure evolution and corrosion resistance of 2205 duplex stainless steel weldments.

Sci Rep

2023 Mar 21

Mohamed AY, Mohamed AHA, Abdel Hamid Z

764. Comprehensive characterization of maternal, fetal, and neonatal microbiomes supports prenatal colonization of the gastrointestinal tract.

Sci Rep

2023 Mar 21

Park JY(#), Yun H(#), Lee SB

765. Off-line measuring sampling data identification parameters for digital twins mirroring load modelling and stability analysis.

Sci Rep

2023 Mar 21

Urquizo J, Ramirez N(#), Sanchez D(#)

766. Potentiated early neural responses to fearful faces are not driven by specific face parts.

Sci Rep

2023 Mar 21

Bruchmann M(#), Mertens L(#), Schindler S

767. The IgV domain of the poliovirus receptor alone is immunosuppressive and binds to its receptors with comparable affinity.

Sci Rep

2023 Mar 21

Saha S(#), Sparkes A(#), Matus EI

768. Chemical-state distributions in charged LiCoO(2) cathode particles visualized by soft X-ray spectromicroscopy.

Sci Rep

2023 Mar 21

Zhang W, Hosono E, Asakura D

769. Revealing the dynamics of ultrarelativistic non-equilibrium many-electron systems with phase space tomography.

Sci Rep

2023 Mar 21

Funkner S, Niehues G, Nasse MJ

770. Steady state oscillations of circular currents in concentric polariton condensates.

Sci Rep

2023 Mar 21

Lukoshkin V, Sedov E, Kalevich V

771. Thermal tolerances of Popenaias popeii (Texas hornshell) and its host fish from the Rio Grande Basin, Texas.

Sci Rep

2023 Mar 21

Rangaswami XL, Goldsmith AM, Khan JM

772. Gravity complexes as a focus of seafloor fluid seepage: the Rio Grande Cone, SE Brazil.

Sci Rep

2023 Mar 21

Ketzer M, Praeg D, Augustin AH

773. Elucidating the molecular mechanisms of essential oils' insecticidal action using a novel cheminformatics protocol.

Sci Rep

2023 Mar 21

Corrêa EJA(#), Carvalho FC(#), de Castro Oliveira JA

774. Evaluation of the attractiveness of lips with different volumes after filling with hyaluronic acid.

Sci Rep

2023 Mar 21

de Queiroz Hernandez PM, Cotrin P, Valarelli FP

775. Pandemic related changes in social interaction are associated with changes in automatic approach-avoidance behaviour.

Sci Rep

2023 Mar 21

Henwood A, Rinck M, Krpan D.

776. Separation, reserve estimation and radioactivity responsibility of the economic heavy minerals of East El- Arish black sand, North Sinai, Egypt.

Sci Rep

2023 Mar 21

Awad M, El Mezayen AM, El Alfi SM

777. The impacts of tidal wetland loss and coastal development on storm surge damages to people and property: a Hurricane Ike case-study.

Sci Rep

2023 Mar 21

Al-Attabi Z, Xu Y, Tso G

778. Machine learning algorithms distinguish discrete digital emotional fingerprints for web pages related to back pain.

Sci Rep

2023 Mar 21

Caldo D(#), Bologna S(#), Conte L

779. Modeling of wear resistance for TC21 Ti-alloy using response surface methodology.

Sci Rep

2023 Mar 21

Abdelmoneim A, Elshaer RN, El-Shennawy M

780. Microbial composition of tumorous and adjacent gastric tissue is associated with prognosis of gastric cancer.

Sci Rep

2023 Mar 21

Lehr K, Nikitina D, Vilchez-Vargas R

781. Effects of routine procedures on salivary cortisol in mechanically ventilated neonates.

Sci Rep

2023 Mar 21

Li W(#), Zhang H(#), Huang X

Even though the stress secondary to invasive procedures has been investigated, less attention has been paid to the stimulation or pain caused by routine procedures on neonates. The changes in salivary cortisol concentration in mechanically ventilated NICU patients during routine procedures were monitored to provide reference and guidance for pain management. 80 mechanically ventilated neonates in the hospital from Sep 2021 to Mar 2022 were selected. The salivary cortisol levels of the neonates were monitored during nursing procedures and were categorized by their risk levels to the following groups: high-risk (endotracheal suctioning and arterial blood sampling), moderate-risk (gastric tube insertion, venipuncture), and low-risk (bedside bathing and diaper changes). The changes in heart rate were also recorded and compared. The concentration of cortisol in the saliva of the neonates was 1.5 ± 0.8 nmol/L during the sleeping state, 6.2 ± 1.3 nmol/L during endotracheal suctioning, 6.4 ± 1.4 nmol/L during arterial blood sampling, 6.1 ± 1.2 nmol/L during venipuncture, 4.4 ± 1.1 nmol/L during gastric tube insertion, 3.5 ± 0.8 nmol/L during bedside bathing, and 3.3 ± 0.9 nmol/L during a diaper change. The results revealed a statistically significant effect between routine procedures on salivary cortisol levels. Compared with the neonates in the control sleep state, there was a significant (P < 0.05) change in salivary cortisol concentration of infants undergoing high and moderate-risk nursing procedures. There was a small but significant (P < 0.05) change in salivary cortisol levels in infants who underwent low-risk procedures compared to infants in the control sleep state. Further, the fluctuation of salivary cortisol levels in routine procedures was more frequent compared with routine handling at night. The fluctuations of salivary cortisol concentration in high-risk procedures were larger than that of infants who underwent low-risk procedures, with the difference being statistically significant (P < 0.05). It was also determined that the top four influencing factors on the infants' heart rate were arterial blood sampling venipuncture, intubation, endotracheal suctioning, and gastric tube insertion (P < 0.05). Monitoring the saliva cortisol concentration index and heart rates can reflect the impact of different routine procedures on newborns and can be used to manage neonatal pain in the future.

782. Network-level analysis of ageing and its relationship with diseases and tissue regeneration in the mouse liver.

Sci Rep

2023 Mar 21

Porukala M, Vinod PK.

783. Interchange of Southern Hemisphere humpback whales across the South Atlantic Ocean.

Sci Rep

2023 Mar 21

Ramos EA, Cheeseman T, Marcondes MCC

784. Microbial bowel infections-induced biochemical and biological abnormalities and their effects on young Egyptian swimmers.

Sci Rep

2023 Mar 21

Hassanein F, Masoud IM, Awwad ZM

785. Non-invasive measurements of ictal and interictal epileptiform activity using optically pumped magnetometers.

Sci Rep

2023 Mar 21

Hillebrand A, Holmes N, Sijsma N

Magneto- and electroencephalography (MEG/EEG) are important techniques for the diagnosis and pre-surgical evaluation of epilepsy. Yet, in current cryogen-based MEG systems the sensors are offset from the scalp, which limits the signal-to-noise ratio (SNR) and thereby the sensitivity to activity from deep structures such as the hippocampus. This effect is amplified in children, for whom adult-sized fixed-helmet systems are typically too big. Moreover, ictal recordings with fixed-helmet systems are problematic because of limited movement tolerance and/or logistical considerations. Optically Pumped Magnetometers (OPMs) can be placed directly on the scalp, thereby improving SNR and enabling recordings during seizures. We aimed to demonstrate the performance of OPMs in a clinical population. Seven patients with challenging cases of epilepsy underwent MEG recordings using a 12-channel OPM-system and a 306-channel cryogen-based whole-head system: three adults with known deep or weak (low SNR) sources of interictal epileptiform discharges (IEDs), along with three children with focal epilepsy and one adult with frequent seizures. The consistency of the recorded IEDs across the two systems was assessed. In one patient the OPMs detected IEDs that were not found with the SQUID-system, and in two patients no IEDs were found with either system. For the other patients the OPM data were remarkably consistent with the data from the cryogenic system, noting that these were recorded in different sessions, with comparable SNRs and IED-yields overall. Importantly, the wearability of OPMs enabled the recording of seizure activity in a patient with hyperkinetic movements during the seizure. The observed ictal onset and semiology were in agreement with previous video- and stereo-EEG recordings. The relatively affordable technology, in combination with reduced running and maintenance costs, means that OPM-based MEG could be used more widely than current MEG systems, and may become an affordable alternative to scalp EEG, with the potential benefits of increased spatial accuracy, reduced sensitivity to volume conduction/field spread, and increased sensitivity to deep sources. Wearable MEG thus provides an unprecedented opportunity for epilepsy, and given its patient-friendliness, we envisage that it will not only be used for presurgical evaluation of epilepsy patients, but also for diagnosis after a first seizure.

786. Machine learning based combination of multi-omics data for subgroup identification in non-small cell lung cancer.

Sci Rep

2023 Mar 21

Khadirnaikar S, Shukla S, Prasanna SRM.

787. A mixed model of heat exchange in stationary honeybee foragers.

Sci Rep

2023 Mar 21

Stabentheiner A, Kovac H.

788. Safeguarding pollinators requires specific habitat prescriptions and substantially more land area than suggested by current policy.

Sci Rep

2023 Mar 21

Pindar A, Raine NE.

789. Ethnic differences in right ventricular structure and function in urbanized hypertensive patients in the Gornaya Shoriya region.

Sci Rep

2023 Mar 21

Sumin AN, Gomozova NS, Shcheglova AV

Aim of this study was to compare right ventricular echocardiography parameters in urbanized hypertensive patients of the Shor and non-indigenous ethnic groups in the Mountain Shoria region. The study included patients with arterial hypertension: 58 Shors and 50 non-indigenous urbanized residents, comparable in age, and divided by ethnicity and gender into 4 groups: Shors men (n = 20), Shors women (n = 38) , non-indigenous men (n = 15) and non-indigenous women (n = 35). All underwent echocardiographic examination, and the right heart parameters were studied. Shor men with arterial hypertension had the lowest values of the pulmonary artery index (p = 0.05), the right atrium dimensions (p = 0.04), and the highest values of the blood flow velocity in the right ventricle, et' (p = 0.05) and st' (p = 0.05) in comparison with non-indigenous men. Shor women have the lowest values Et/At ratios (p = 0.05). RV diastolic dysfunction was detected mainly in women compared with men (23.1% and 1.9%, p = 0.0014), somewhat more often in Shors. Ethnicity was one of the factors associated with the right ventricular diastolic dysfunction presence (p = 0.002). Among the factors associated with the RV diastolic dysfunction were risk factors (smoking, obesity), blood pressure, gender, ethnicity, and left ventricular parameters (diastolic dysfunction and the myocardial mass increase). Thus, our study established the influence of ethnic differences on the right heart echocardiographic parameters in Shors and Caucasians with arterial hypertension. The effect of sex on RV diastolic dysfunction was a lot bigger compared to the effect of ethnicity. The revealed differences should improve the assessment of the right heart structure and function in patients with arterial hypertension from small ethnic groups, which will help to improve the diagnosis and treatment of such patients.

790. Characterization of serum and tissue oxytocinase and tissue oxytocin in the pregnant and non-pregnant mare.

Sci Rep

2023 Mar 21

Diel de Amorim M, Dong L, Byron M

791. Interspecific hybridization for transfer of hull-less seed trait from Cucurbita pepo to C. moschata.

Sci Rep

2023 Mar 21

Kaur B, Garcha KS, Sandhu JS

792. Impact of the COVID-19 pandemic on levels of deep-ocean acoustic noise.

Sci Rep

2023 Mar 21

Robinson S, Harris P, Cheong SH

793. Influence of altered serum and muscle concentrations of BDNF on electrophysiological properties of spinal motoneurons in wild-type and BDNF-knockout rats.

Sci Rep

2023 Mar 20

Grzelak N, Krutki P, Bączyk M

794. Probing the link between cortical inhibitory and excitatory processes and muscle fascicle dynamics.

Sci Rep

2023 Mar 20

Lauber B, Taube W.

795. Influence of α-amylase, xylanase and cellulase on the rheological properties of bread dough enriched with oat bran.

Sci Rep

2023 Mar 20

Liu W, Brennan M, Tu D

796. Ray tracing optimization: a new method for intraocular lens power calculation in regular and irregular corneas.

Sci Rep

2023 Mar 20

Pérez-Merino P, Aramberri J, Quintero AV

797. Development and validation of new predictive equations for resting energy expenditure in physically active boys.

Sci Rep

2023 Mar 20

Łuszczki E, Jagielski P, Bartosiewicz A

798. Evaluation of transcutaneous near-infrared spectroscopy for early detection of cardiac arrest in an animal model.

Sci Rep

2023 Mar 20

Raschdorf K, Mohseni A, Hogle K

799. Ecological risk assessment of trace elements (TEs) pollution and human health risk exposure in agricultural soils used for saffron cultivation.

Sci Rep

2023 Mar 20

Taghavi M, Darvishiyan M, Momeni M

Contamination of farmland soils by trace elements (TEs) has become an international issue concerning food safety and human health risks. In the present research, the concentrations of TEs including cadmium (Cd), cobalt (Co), chromium (Cr), copper (Cu), manganese (Mn), nickel (Ni), lead (Pb), zinc (Zn) and iron (Fe) in soils of 16 farmlands were determined in Gonabad, Iran. In addition, the human health risks due to exposure to the TEs from the soils were assessed. Moreover, the soil contamination likelihood was evaluated based on various contamination indices including contamination factor [Formula: see text]), enrichment factor (EF), geo-accumulation index (Igeo), and pollution load index (PLI) calculations. The soil mean concentrations for Cd, Co, Cr, Cu, Mn, Ni, Pb, Zn and Fe ranges as 0.102, 6.968, 22.550, 29.263, 475.281, 34.234, 13.617, 54.482 and 19,683.6 mg/kg in farmland soils. The mean concentrations of the TEs decreased in the order of Fe > Mn > Zn > Ni > Cu > Cr > Pb > Co > As > Cd. Levels of all metals in this study were within the FAO/WHO and Iranian soil standards. The HQ values from investigated elements for adults and children in the studied farms were less than the limit of 1, indicating no health risks for the studied subpopulations. The results of the present research indicated no significant carcinogenic health hazards for both adults and children through ingestion, skin contact and inhalation exposure routes. [Formula: see text] values of Ni and Zn in 100% and 6.25% of farmlands were above 1, showing moderate contamination conditions. EF values of metals in farmlands were recorded as "no enrichment", "minimal enrichment" and "moderate enrichment" classes. Furthermore, it can be concluded that the all farms were uncontaminated except Ni (moderately contaminated) based on Igeo. This is an indication that the selected TEs in the agricultural soils have no appreciable threat to human health.

800. Safety and effect of pipeline flex embolization device for complex unruptured intracranial aneurysms.

Sci Rep

2023 Mar 20

Chen SQ(#), Li L(#), Gao BL

801. Surface rupture and landscape response in the middle of the great Mw 8.3 1934 earthquake mesoseismal area: Khutti Khola site.

Sci Rep

2023 Mar 20

Riesner M, Bollinger L, Rizza M

802. A novel, extreme low-cost poly (Erythrosine) modified pencil graphite electrode for determination of Adrenaline.

Sci Rep

2023 Mar 20

Sukanya SD, Swamy BEK, Shashikumara JK

803. Effects of endovascular recanalization on symptomatic non-acute occlusion of intracranial arteries.

Sci Rep

2023 Mar 20

Xia J, Gao H, Zhang K

804. Computational study of blood flow inside MCA aneurysm with/without endovascular coiling.

Sci Rep

2023 Mar 20

Sadeh A, Kazemi A, Bahramkhoo M

805. An econometric analysis for the determinants of flight speed in the air transport of passengers.

Sci Rep

2023 Mar 20

de Almeida EE, Oliveira AVM.

806. The distribution of submerged macrophytes in response to intense solar radiation and salinity reveals hydrogen peroxide as an abiotic stress indicator.

Sci Rep

2023 Mar 20

Asaeda T, Rashid MH, Liping X

807. Clinical parameters predictors of malignant transformation of recurrent parotid pleomorphic adenoma.

Sci Rep

2023 Mar 20

Pei Y, Li W.

808. Use of laboratory-developed assays in global HIV-1 treatment-monitoring and research.

Sci Rep

2023 Mar 20

Malisa J, Manak M, Michelo C

809. Geriatric nutritional risk index as a prognostic marker for patients with upper tract urothelial carcinoma receiving radical nephroureterectomy.

Sci Rep

2023 Mar 20

Chang LW, Hung SC, Chen CS

810. Diseased and healthy murine local lung strains evaluated using digital image correlation.

Sci Rep

2023 Mar 20

Nelson TM, Quiros KAM, Dominguez EC

811. Cardiovascular disease preventive effects of aspirin combined with different statins in the United States general population.

Sci Rep

2023 Mar 20

Liu T, Zuo R, Wang J

812. A mathematical model and numerical simulation for SARS-CoV-2 dynamics.

Sci Rep

2023 Mar 20

Amoddeo A.

813. Physiological responses of three field-grown species (Ceratonia siliqua, Eucalyptus camaldulensis, and Moringa oleifera) to water deficits in a Mediterranean semi-arid climate.

Sci Rep

2023 Mar 20

Ezzine H, Metougui ML, Boukcim H

814. The relationship between physical exercise and smoking behavior among Chinese residents aged 16 years and older.

Sci Rep

2023 Mar 20

Tie Y, Tian W, Chen Y

To explore the relationship between physical exercise and smoking behavior among Chinese residents aged 16 years and older. Analysis based on 29,466 validated cases in the 2018 China Family Panel Studies (CFPS 2018). The chi-square test and Mann-Whitney U test were used for comparative analysis between groups. Logistic regression analysis was used to explore the relationship between physical exercise and smoking behavior. Gender and birth cohort differences in the relationship between physical exercise and smoking behavior were explored based on stratified regression analysis using gender and birth cohort as stratified variables, respectively. Robustness testing based on multiple linear regression analysis using a replacement data approach. There were 8735 cases of smokers among the respondents. After controlling for relevant confounders, there was a significant negative association between physical exercise and smoking behavior among residents [OR 0.718, 95% CI (0.673, 0.765), P < 0.01]. Physical exercise was more significantly associated with smoking behavior among male residents [OR 0.694, 95% CI (0.649, 0.743), P < 0.01], while it was not significantly associated with smoking behavior among female residents [OR 0.901, 95% CI (0.743, 1.093), P > 0.05]. Physical exercise was more significantly associated with smoking behavior in the pre-1948 (OR 0.748), 1959-1968 (OR 0.748), 1969-1978 (OR 0.812), 1989-1998 (OR 0.576) and post-1999 (OR 0.411) birth cohorts, and the association decreased over time and with social change. The results of the robustness test showed that frequency of exercise was significantly and negatively associated with smoking behavior among residents [OR 0.961, 95% CI (0.951, 0.970), P < 0.01]. Physical exercise is negatively associated with smoking behavior among Chinese residents aged 16 years and older, especially among male residents. There is a cohort effect between physical exercise and smoking behavior of the population, that is, the relationship between the two decreases with social change.

815. Synchronized oscillations of carbon nanotubes dispersed in solution.

Sci Rep

2023 Mar 20

Fukumoto M, Akai R, Yoshida Y

816. Relative age effect and performance in elite youth male basketball.

Sci Rep

2023 Mar 20

Tascioglu R, Atalag O, Yuksel Y

817. SCAPS simulation of novel inorganic ZrS(2)/CuO heterojunction solar cells.

Sci Rep

2023 Mar 20

Abdelfatah M, El Sayed AM, Ismail W

818. Exploring the impact mechanism of low-carbon multivariate coupling system in Chinese typical cities based on machine learning.

Sci Rep

2023 Mar 20

Yang H, Chen L, Huang H

819. Medication adherence in patients with cluster headache and migraine: an online survey.

Sci Rep

2023 Mar 20

Rimmele F, Müller B, Becker-Hingst N

820. Possible species discrimination of a blotched nerite Nerita albicilla with their distribution pattern and demographic history in the Indo-Pacific.

Sci Rep

2023 Mar 20

Hong S(#), Park B(#), Kim G

821. Extracellular vesicles are dynamic regulators of maternal glucose homeostasis during pregnancy.

Sci Rep

2023 Mar 20

Zierden HC, Marx-Rattner R, Rock KD

822. Inhibition of TGF-β signaling enables long-term proliferation of mouse primary epithelial stem/progenitor cells of the tympanic membrane and the middle ear mucosa.

Sci Rep

2023 Mar 20

Yamamoto-Fukuda T, Pinto F, Pitt K

823. High temperature performance of wire-arc additive manufactured Inconel 718.

Sci Rep

2023 Mar 20

James WS, Ganguly S, Pardal G.

824. Contrast-enhanced CT-based Radiomics for the Differentiation of Anaplastic or Poorly Differentiated Thyroid Carcinoma from Differentiated Thyroid Carcinoma: A Pilot Study.

Sci Rep

2023 Mar 20

Moon J(#), Lee JH(#), Roh J

825. A novel intelligent bearing fault diagnosis method based on signal process and multi-kernel joint distribution adaptation.

Sci Rep

2023 Mar 20

Xiong J, Cui S, Tang H.

826. High-performance surface plasmon resonance fiber sensor based on cylindrical vector modes.

Sci Rep

2023 Mar 20

Sharif V, Pakarzadeh H.

827. The utility of airborne hyperspectral and satellite multispectral images in identifying Natura 2000 non-forest habitats for conservation purposes.

Sci Rep

2023 Mar 20

Jarocińska A, Kopeć D, Niedzielko J

Aerial hyperspectral and multispectral satellite data are the two most commonly used datasets to identify natural and semi-natural vegetation. However, there is no documented analysis based on data from several areas concerning the difference in the classification accuracy of non-forest Natura 2000 habitat with the use of aerial hyperspectral and satellite multispectral data. Also, there is no recommendation, on which habitat can be classified with sufficient accuracy using free multispectral images. This study aimed to analyse the difference in classification accuracy of Natura 2000 habitats representing: meadows, grasslands, heaths and mires between data with different spectral resolutions and the results utility for nature conservation compared to conventional maps. The analysis was conducted in five study areas in Poland. The classification was performed on multispectral Sentinel-2 (S2) and hyperspectral HySpex (HS) images using the Random Forest algorithm. Based on the results, it can be stated that the use of HS data resulted in higher classification accuracy, on average 0.14, than using S2 images, regardless of the area of the habitat. However, the difference in accuracy was not constant, varying by area and habitat characterisation. Greater differences in accuracy were observed for areas where habitats were characterised by high α-diversity or β-diversity. The HS and S2 data make it possible to create maps that provide a great deal of new knowledge about the distribution of Natura 2000 habitats, which is necessary for the management of protected areas. The obtained results indicate that by using S2 images it is possible to identify, at a satisfactory level, alluvial meadows and grassland. For heaths and mires, using HS data improved the results, but it is also possible to acquire general distribution of these classes, whereas HS images are obligatory for mapping salt, Molinia and lowland hay meadows.

828. Comparison of antioxidant activity in various spirulina containing products and factors affecting it.

Sci Rep

2023 Mar 20

Stunda-Zujeva A, Berele M, Lece A

829. Spatial variation in red deer density in a transboundary forest ecosystem.

Sci Rep

2023 Mar 20

Tourani M, Franke F, Heurich M

Forests in Europe are exposed to increasingly frequent and severe disturbances. The resulting changes in the structure and composition of forests can have profound consequences for the wildlife inhabiting them. Moreover, wildlife populations in Europe are often subjected to differential management regimes as they regularly extend across multiple national and administrative borders. The red deer Cervus elaphus population in the Bohemian Forest Ecosystem, straddling the Czech-German border, has experienced forest disturbances, primarily caused by windfalls and bark beetle Ips typographus outbreaks during the past decades. To adapt local management strategies to the changing environmental conditions and to coordinate them across the international border, reliable estimates of red deer density and abundance are highly sought-after by policymakers, wildlife managers, and stakeholders. Covering a 1081-km2 study area, we conducted a transnational non-invasive DNA sampling study in 2018 that yielded 1578 genotyped DNA samples from 1120 individual red deer. Using spatial capture-recapture models, we estimated total and jurisdiction-specific abundance of red deer throughout the ecosystem and quantified the role of forest disturbance and differential management strategies in shaping spatial heterogeneity in red deer density. We hypothesised that (a) forest disturbances provide favourable habitat conditions (e.g., forage and cover), and (b) contrasting red deer management regimes in different jurisdictions create a differential risk landscape, ultimately shaping density distributions. Overall, we estimated that 2851 red deer (95% Credible Interval = 2609-3119) resided in the study area during the sampling period, with a relatively even overall sex ratio (1406 females, 95% CI = 1229-1612 and 1445 males, 95% CI = 1288-1626). The average red deer density was higher in Czechia (3.5 km-2, 95% CI = 1.2-12.3) compared to Germany (2 km-2, 95% CI = 0.2-11). The effect of forest disturbances on red deer density was context-dependent. Forest disturbances had a positive effect on red deer density at higher elevations and a negative effect at lower elevations, which could be explained by partial migration and its drivers in this population. Density of red deer was generally higher in management units where hunting is prohibited. In addition, we found that sex ratios differed between administrative units and were more balanced in the non-intervention zones. Our results show that the effect of forest disturbances on wild ungulates is modulated by additional factors, such as elevation and ungulate management practices. Overall density patterns and sex ratios suggested strong gradients in density between administrative units. With climate change increasing the severity and frequency of forest disturbances, population-level monitoring and management are becoming increasingly important, especially for wide-ranging species as both wildlife and global change transcend administrative boundaries.

830. Development of a novel experimental technique for the measurement of residual wall layer thickness in water-oil displacement flows.

Sci Rep

2023 Mar 20

Zhang Y, Barrouillet B, Chavan SM

The effective removal and displacement of fluids is important in many industrial and environmental applications, such as for operation and cleaning of process equipment, fluid injection in porous media for oil recovery or aquifer remediation, or for achieving subsurface zonal isolation in new or abandoned wells. The accurate measurement of the residual fluid wall film left behind after displacement by a cleaning fluid is a long-standing challenge, particularly so for very thin fluid films where the thickness can be of the order of micrometer. We focus on the characterization of oil films left on the wall of a horizontal pipe after the pipe has been displaced by water, and develop a novel, non-intrusive analytical technique that allows the use of relevant pipe materials. The oil that originally occupies the pipe is stained by a hydrophobic dye Nile red, and an intermediate organic solvent is used to collect the residual oil volume that remains after displacing the pipe with a known volume of water. Finally, ultraviolet-visible spectroscopy is used to measure the Nile red concentration in the collected fluid, which is proportional to the residual volume of oil in the pipe. We demonstrate the methodology by conducting experiments where the displacing fluid is injected at two different imposed velocities, and where the injected fluid volume is varied. As expected, we find a gradual thinning of the oil film with increasing injected fluid volume. We compare the measured film thicknesses to a displacement model based on the steady velocity profile in a pipe, and find that experiments consistently produce smaller film thicknesses. This developed technique allows quantification of displacement and cleaning mechanisms involved in immiscible displacements at laminar, transitional and turbulent regimes, for different non-Newtonian fluid pairs, and for different realistic pipe materials and surface roughnesses.

831. Association between handgrip strength and heart failure in adults aged 45 years and older from NHANES 2011-2014.

Sci Rep

2023 Mar 20

Li RM, Dai GH, Guan H

832. Muscle prestimulation tunes velocity preflex in simulated perturbed hopping.

Sci Rep

2023 Mar 20

Izzi F, Mo A, Schmitt S

833. Probing the behavior and kinetic studies of amphiphilic acrylate copolymers with bovine serum albumin.

Sci Rep

2023 Mar 20

Mushtaq S, Abbas MA, Nasir H

834. Study on mechanical characteristics of anchor drilling rig group for rapid excavating.

Sci Rep

2023 Mar 20

Xie M, Zhang HY, Li YQ

Aiming at the imbalance problem of excavating and anchoring efficiency ratio in the underground coal mine, a new type of parallel operation unit of excavation-supporting-anchoring is proposed to improve the excavating efficiency. Considering the uneven factors of the roof and floor of the coal mine roadway, the influence of different drilling angles and leg support angles on the leg support force is studied under the condition of simultaneous drilling of multiple drilling rigs. The results show that the maximum support force is 4.002 KN when the leg angle is different and the drilling angle is different. By constructing the coupling vibration model of the multi-drill drilling process and using the Lagrange method to solve the vibration law of key components of the anchorage system, the vibration law of drill pipe under different influencing factors such as cantilever extension, multi-drill simultaneous drilling, and drilling incident angle is studied. The results showed: (1) The vibration of the drill pipe in the cantilever extension state is more severe than that in the retracted state, and the maximum vibration peak reaches 7.61 mm. (2) The vibration response of the drill pipe is the most intense under the condition of four top anchor drilling rigs drilling at the same time. Under the working condition of only two drilling rigs, the vibration response of the drill pipe is the smallest. (3) As the drilling angle of the drilling rig increases, the vibration response of the drill pipe is more severe and the vibration amplitude is larger. A test prototype is built to simulate the actual anchoring drilling process, and the vibration law of the support platform and the drilling rig is obtained through the vibration detection system. The test results show that the vibration law of the key components is approximately the same as the theoretical simulation results. The relevant theoretical results can provide a technical basis for the drilling stability of the anchoring system.

835. A study on Shine-Muscat grape detection at maturity based on deep learning.

Sci Rep

2023 Mar 20

Wei X, Xie F, Wang K

836. Nanopore Sequencing Discloses Compositional Quality of Commercial Probiotic Feed Supplements.

Sci Rep

2023 Mar 20

Kruasuwan W, Jenjaroenpun P, Arigul T

837. Frozen fresh blood plasma preserves the functionality of native human α(2)-macroglobulin.

Sci Rep

2023 Mar 20

Mendes SR, Gomis-Rüth FX, Goulas T.

838. Impacts of Mg doping on the structural properties and degradation mechanisms of a Li and Mn rich layered oxide cathode for lithium-ion batteries.

Sci Rep

2023 Mar 20

Kaewmala S, Kamma N, Buakeaw S

839. Grain boundary widening controls siderite (FeCO(3)) replacement of limestone (CaCO(3)).

Sci Rep

2023 Mar 20

Weber J, Starchenko V, Ilavsky J

840. Physical and mental health impact of the COVID-19 pandemic at first year in a Spanish adult cohort.

Sci Rep

2023 Mar 20

Castellvi Obiols P, Miranda-Mendizabal A, Recoder S

The COVID-19 pandemic and the political and health measures have profoundly affected the health of our populations. However, very few studies have been published assessing its impact using a prospective cohort. The aim of this study is to describe the impact on physical and mental health due to the COVID-19 pandemic in the general population in Spain, and according to COVID-19 clinical status, during the first year of the pandemic. A longitudinal cohort study with two online surveys were performed on a representative sample of the adult Spanish population before (N = 2005, October/November 2019) and during the pandemic (N = 1357, November/December 2020). We assessed disability using the World Health Organisation Disability Assessment Schedule (WHODAS), major depressive episode (MDE) and suicidal thoughts and behaviours (STB), using an adapted version of the Composite International Diagnostic Interview (CIDI 3.0); generalised anxiety disorder (GAD) using the GAD-7 scale; post-traumatic stress disorder (PTSD) symptoms using the PTSD checklist for DSM-5 (PCL-5). For physical health, there was a statistically significant loss of weight (mean/SD) (T0, 73.22/15.56 vs. T1, 71.21/11.94), less use of tobacco (T0, 11.4% vs. T1, 9.0%) and decreased disability (mean/SD) (T0, 21.52/9.22 vs. T1, 19.03/7.32). For mental health, there was a significant increase in MDE (T0, 6.5% vs. T1, 8.8%) and in the prevalence of GAD (T0, 13.7% vs. T1, 17.7%). The prevalence of STB (T0, 15.1% vs. T1, 7.1%) significantly decreased. Individuals who declared they had been diagnosed with COVID-19 (3.6%) showed a worsening in physical health and an increase in mental health problems and PTSD symptoms. Although suicide risk during the first year of the pandemic was significantly less, many suicide risk factors increased: such as the incidence and persistence of MDE and GAD, the presence of PTSD symptoms in those diagnosed with COVID-19, and a worsening in self-assessed health status. We expect an increase in STB in the population in the long-term. Future research should gather information about the long-term impact of the pandemic.

841. MDM2 inhibitors, nutlin-3a and navtemadelin, retain efficacy in human and mouse cancer cells cultured in hypoxia.

Sci Rep

2023 Mar 20

Lerma Clavero A, Boqvist PL, Ingelshed K

842. An exploratory approach to identify microRNAs as circulatory biomarker candidates for epilepsy-associated psychiatric comorbidities in an electrical post-status epilepticus model.

Sci Rep

2023 Mar 20

von Rüden EL(#), Janssen-Peters H(#), Reiber M(#)

843. Evaluation of the growth, adaption, and ecosystem services of two potentially-introduced urban tree species in Guangzhou under drought stress.

Sci Rep

2023 Mar 2

Zhang M, Ni Y, Li M.

Under rapid urbanization and agglomeration of population, cities are facing various environmental challenges. As urban forests play a crucial role in mitigating native environmental problems and providing ecosystem services, cities might enhance their urban forest construction through multiple approaches, of which the introduction of exotic tree species could be an effective way. Under the background of constructing a high-quality forest city, Guangzhou was considering introducing a series of exotic tree species to improve the local urban greening, among which Tilia cordata Mill. and Tilia tomentosa Moench became the potential objects. As Guangzhou was reported to experience higher temperatures with less precipitation and face drought events with increasing frequency and intensity, whether the two tree species could survive in the dry environment required to be investigated profoundly. Thus, we launched a drought-simulation experiment and measured their above- and below-ground growth in 2020. In addition, their ecosystem services were also simulated and evaluated for their future adaption. Furthermore, a congeneric native tree species Tilia miqueliana Maxim was also measured in the same experiment as a comparison. Our results showed that Tilia miqueliana exhibited moderate patterns of growth and advantages in evapotranspiration and cooling. Besides, its investment in root development at horizontal level could account for its special strategy against drought stress. Tilia tomentosa's vigorous root growth could be the most positive behavior of coping with water deficit, which explained its maintenance of carbon fixation and implied a well adaption. Tilia cordata showed a complete decrease in above- and below-ground growth, especially for its fine root biomass. In addition, its ecosystem services were significantly reduced, reflecting a comprehensive failure when it faced a long-term scarcity of water. Therefore, it was necessary to supply sufficient water and under-ground space for their living in Guangzhou, especially for Tilia cordata. In the future, long-time observation of their growth under different stresses can be practical approaches to amplify their multiple ecosystem services.

844. Health literacy affected the residents' knowledge, attitude, practice for prevention and control of COVID-19 in Shanxi Province, China.

Sci Rep

2023 Mar 2

Ling J(#), Jiang H(#), Wang X

Multistage stratified random sampling was used to explore the relationship of health literacy with novel coronavirus disease 2019 (COVID-19) prevention and control knowledge, attitude and practice (KAP) in residents aged 15-69 years old in Shanxi Province. The questionnaire, which was issued by the Chinese Center for Health Education, consisted of a health literacy questionnaire and a COVID-19 prevention and control KAP questionnaire. According to the national unified scoring method, the participants were divided into two groups: those who with adequate health literacy and those who with inadequate health literacy. The results of the answer to each KAP question were compared between the two groups by Chi-square test or Wilcoxon rank sum test. Binary logistic regression was used to control confounding effects of socio-demographic characteristics to draw relatively reliable conclusions. A total of 2700 questionnaires were distributed, and 2686 valid questionnaires were returned, with an efficiency rate of 99.5%. Health literacy qualified was identified for 18.32% (492/2686) in Shanxi Province. Compared with the inadequate health literacy group, people with adequate health literacy had a higher corrected answer rate in 11 knowledge-related questions (all P < 0.001); showed more positive answer to each attitude-related question in the three aspects, namely, responsibility for the prevention and control of infectious disease transmission, evaluation for COVID-19-related information release and reporting, and evaluation for the government's COVID-19 prevention and control results (all P < 0.001); and acted more actively in the practice concerning appropriate self-prevention and control behaviors during the COVID-19 outbreak (all P < 0.001). Logistic regression analyses confirmed that with adequate health literacy played a positive role in each of the contents of COVID-19 prevention and control KAP (ORs were between 1.475 and 4.862, all P < 0.001). Health literacy is closely related to COVID-19 prevention and control KAP in the general population of Shanxi Province. People with high score of health literacy were generally better able to grasp COVID-19 prevention and control knowledge, have more positive attitudes toward prevention and control, and perform better prevention and control behaviors. Promoting residents' health literacy by targeted health education can play an important and positive role in dealing with the threat of major infectious diseases outbreaks.

845. Elevated serum levels of bone morphogenetic protein-9 are associated with better outcome in AQP4-IgG seropositive NMOSD.

Sci Rep

2023 Mar 2

Masuda H, Mori M, Uzawa A

846. Inhaled milrinone in cardiac surgical patients: pharmacokinetic and pharmacodynamic exploration.

Sci Rep

2023 Mar 2

Nguyen AQ, Denault AY, Théoret Y

Mean arterial pressure to mean pulmonary arterial pressure ratio (mAP/mPAP) has been identified as a strong predictor of perioperative complications in cardiac surgery. We therefore investigated the pharmacokinetic/pharmacodynamic (PK/PD) relationship of inhaled milrinone in these patients using this ratio (R) as a PD marker. Following approval by the ethics and research committee and informed consent, we performed the following experiment. Before initiation of cardiopulmonary bypass in 28 pulmonary hypertensive patients scheduled for cardiac surgery, milrinone (5 mg) was nebulized, plasma concentrations measured (up to 10 h) and compartmental PK analysis carried out. Baseline (R0) and peak (Rmax) ratios as well as magnitude of peak response (∆Rmax-R0) were measured. During inhalation, individual area under effect-time (AUEC) and plasma concentration-time (AUC) curves were correlated. Potential relationships between PD markers and difficult separation from bypass (DSB) were explored. In this study, we observed that milrinone peak concentrations (41-189 ng ml-1) and ΔRmax-R0 (- 0.12-1.5) were obtained at the end of inhalation (10-30 min). Mean PK parameters agreed with intravenous milrinone published data after correction for the estimated inhaled dose. Paired comparisons yielded a statistically significant increase between R0 and Rmax (mean difference, 0.58: 95% CI 0.43-0.73; P < 0.001). Individual AUEC correlated with AUC (r = 0.3890, r2 = 0.1513; P = 0.045); significance increased after exclusion of non-responders (r = 4787, r2 = 0.2292; P = 0.024). Individual AUEC correlated with ∆Rmax-R0 (r = 5973, r2 = 0.3568; P = 0.001). Both ∆Rmax-R0 (P = 0.009) and CPB duration (P < 0.001) were identified as predictors of DSB. In conclusion, both magnitude of peak response of the mAP/mPAP ratio and CPB duration were associated with DSB.

847. Investigation of the effective atomic number dependency on kinetic energy using collision stopping powers for electrons, protons, alpha, and carbon particles.

Sci Rep

2023 Mar 2

Rezaeian P, Kashian S, Mehrara R.

848. Cluster analysis of plasma cytokines identifies two unique endotypes of children with asthma in the pediatric intensive care unit.

Sci Rep

2023 Mar 2

Cottrill KA, Rad MG, Ripple MJ

849. Common features in spatial livestock disease transmission parameters.

Sci Rep

2023 Mar 2

Boender GJ, Hagenaars TJ.

850. Characteristics and FEA verification of the attraction between like magnetic poles.

Sci Rep

2023 Mar 2

Chen CH, Zou M, Ran S

851. A study on disability glare vision in young adult subjects.

Sci Rep

2023 Mar 2

Casado P, Ávila FJ, Collados MV

852. Effects of occipital-atlas stabilization on the upper cervical spine rotation combinations: an in vitro study.

Sci Rep

2023 Mar 2

Hidalgo-García C(#), Lorente AI(#), López-de-Celis C

The purpose of this study is to compare axial rotation range of motion for the upper cervical spine during three movements: axial rotation, rotation + flexion + ipsilateral lateral bending and rotation + extension + contralateral lateral bending before and after occiput-atlas (C0-C1) stabilization. Ten cryopreserved C0-C2 specimens (mean age 74 years, range 63-85 years) were manually mobilized in 1. axial rotation, 2. rotation + flexion + ipsilateral lateral bending and 3. rotation + extension + contralateral lateral bending without and with a screw stabilization of C0-C1. Upper cervical range of motion and the force used to generate the motion were measured using an optical motion system and a load cell respectively. The range of motion (ROM) without C0-C1 stabilization was 9.8° ± 3.9° in right rotation + flexion + ipsilateral lateral bending and 15.5° ± 5.9° in left rotation + flexion + ipsilateral lateral bending. With stabilization, the ROM was 6.7° ± 4.3° and 13.6° ± 5.3°, respectively. The ROM without C0-C1 stabilization was 35.1° ± 6.0° in right rotation + extension + contralateral lateral bending and 29.0° ± 6.5° in left rotation + extension + contralateral lateral bending. With stabilization, the ROM was 25.7° ± 6.4° (p = 0.007) and 25.3° ± 7.1°, respectively. Neither rotation + flexion + ipsilateral lateral bending (left or right) or left rotation + extension + contralateral lateral bending reached statistical significance. ROM without C0-C1 stabilization was 33.9° ± 6.7° in right rotation and 28.0° ± 6.9° in left rotation. With stabilization, the ROM was 28.5° ± 7.0° (p = 0.005) and 23.7° ± 8.5° (p = 0.013) respectively. The stabilization of C0-C1 reduced the upper cervical axial rotation in right rotation + extension + contralateral lateral bending and right and left axial rotations; however, this reduction was not present in left rotation + extension + contralateral lateral bending or both combinations of rotation + flexion + ipsilateral lateral bending.

853. Crystal orientation-dependent tensile mechanical behavior and deformation mechanisms of zinc-blende ZnSe nanowires.

Sci Rep

2023 Mar 2

Islam ASMJ, Hasan MS, Islam MS

854. Zinc oxide nanoparticles induce oxidative stress, genotoxicity, and apoptosis in the hemocytes of Bombyx mori larvae.

Sci Rep

2023 Mar 2

Belal R, Gad A.

855. Mapping peripheral and abdominal sarcopenia acquired in the acute phase of COVID-19 during 7 days of mechanical ventilation.

Sci Rep

2023 Mar 2

de Moura PH, de Souza H, Brandão DC

856. Effect of tissue-grouped regulatory variants associated to type 2 diabetes in related secondary outcomes.

Sci Rep

2023 Mar 2

Hemerich D, Smit RAJ, Preuss M

857. Modified variational autoencoder for inversely predicting plasmonic nanofeatures for generating structural color.

Sci Rep

2023 Mar 2

Pillai P, Rai B, Pal P.

858. MicroRNAs and cytokines as potential predictive biomarkers for COVID-19 disease progression.

Sci Rep

2023 Mar 2

Mohamed HA, Abdelkafy AE, Khairy RMM

Host microRNAs can influence the cytokine storm associated SARS-CoV-2 infection and proposed as biomarkers for COVID-19 disease. In the present study, serum MiRNA-106a and miRNA-20a were quantified by real time-PCR in 50 COVID-19 patients hospitalized at Minia university hospital and 30 healthy volunteers. Profiles of serum inflammatory cytokines (TNF-α, IFN-γ, and IL-10) and TLR4 were analyzed by Eliza in patients and controls. A highly significant decrease (P value = 0.0001) in the expressions of miRNA-106a and miRNA-20a was reported in COVID-19 patients compared to controls. A significant decrease in the levels of miRNA-20a was also reported in patients with lymphopenia, patients having chest CT severity score (CSS) > 19 and in patients having O2 saturation less than 90%. Significantly higher levels of TNF-α, IFN-γ, IL-10 and TLR4 were reported in patients compared to controls. IL-10 and TLR4 levels were significantly higher in patients having lymphopenia. TLR-4 level was higher in patients with CSS > 19 and in patients with hypoxia. Using univariate logistic regression analysis, miRNA-106a, miRNA-20a, TNF-α, IFN-γ, IL-10 and TLR4 were identified as good predictors of disease. Receiver operating curve showed that the downregulation of miRNA-20a in patients having lymphopenia, patients with CSS > 19 and patients with hypoxia could be a potential biomarker with AUC = 0.68 ± 0.08, AUC = 0.73 ± 0.07 and AUC = 0.68 ± 0.07 respectively. Also, ROC curve showed accurate association between the increase of serum IL-10 and TLR-4 and lymphopenia among COVID-19 patients with AUC = 0.66 ± 0.08 and AUC = 0.73 ± 0.07 respectively. ROC curve showed also that serum TLR-4 could be a potential marker for high CSS with AUC = 0.78 ± 0.06. A negative correlation was detected between miRNA-20a with TLR-4 (r = - 0.30, P value = 0.03). We concluded that, miR-20a, is a potential biomarker of COVID-19 severity and blockade of IL-10 and TLR4 may constitute a novel therapy for COVID-19 patients.

859. Multidimensional variability in ecological assessments predicts two clusters of suicidal patients.

Sci Rep

2023 Mar 2

Bonilla-Escribano P, Ramírez D, Baca-García E

860. Multi-order graph attention network for water solubility prediction and interpretation.

Sci Rep

2023 Mar 2

Lee S(#), Park H(#), Choi C

861. Decoding behavior from global cerebrovascular activity using neural networks.

Sci Rep

2023 Mar 2

Berthon B(#), Bergel A(#), Matei M

862. Dynamic analysis of towed cable with variable length during turning maneuvers.

Sci Rep

2023 Mar 2

Zhang D, Zhao B, Zhu K

863. Effect of mycorrhizae on phosphate fertilization efficiency and maize growth under field conditions.

Sci Rep

2023 Mar 2

de Souza Buzo F, Garé LM, Garcia NFS

864. Assessment of ITER radiation environment during the remote-handling operation of In-Vessel components with D1SUNED.

Sci Rep

2023 Mar 2

Martínez-Albertos P, Sauvan P, Loughlin MJ

865. New machine learning-based automatic high-throughput video tracking system for assessing water toxicity using Daphnia Magna locomotory responses.

Sci Rep

2023 Mar 2

Kim J, Yuk H, Choi B

Daphnia magna is an important organism in ecotoxicity studies because it is sensitive to toxic substances and easy to culture in laboratory conditions. Its locomotory responses as a biomarker are highlighted in many studies. Over the last several years, multiple high-throughput video tracking systems have been developed to measure the locomotory responses of Daphnia magna. These high-throughput systems, used for high-speed analysis of multiple organisms, are essential for efficiently testing ecotoxicity. However, existing systems are lacking in speed and accuracy. Specifically, speed is affected in the biomarker detection stage. This study aimed to develop a faster and better high-throughput video tracking system using machine learning methods. The video tracking system consisted of a constant temperature module, natural pseudo-light, multi-flow cell, and an imaging camera for recording videos. To measure Daphnia magna movements, we developed a tracking algorithm for automatic background subtraction using k-means clustering, Daphnia classification using machine learning methods (random forest and support vector machine), and tracking each Daphnia magna location using the simple online real-time tracking algorithm. The proposed tracking system with random forest performed the best in terms of identification (ID) precision, ID recall, ID F1 measure, and ID switches, with scores of 79.64%, 80.63%, 78.73%, and 16, respectively. Moreover, it was faster than existing tracking systems such as Lolitrack and Ctrax. We conducted an experiment to observe the impact of toxicants on behavioral responses. Toxicity was measured manually in the laboratory and automatically using the high-throughput video tracking system. The median effective concentration of Potassium dichromate measured in the laboratory and using the device was 1.519 and 1.414, respectively. Both measurements conformed to the guideline provided by the Environmental Protection Agency of the United States; therefore, our method can be used for water quality monitoring. Finally, we observed Daphnia magna behavioral responses in different concentrations after 0, 12, 18, and 24 h and found that there was a difference in movement according to the concentration at all hours.

866. The role of dung beetle species in nitrous oxide emission, ammonia volatilization, and nutrient cycling.

Sci Rep

2023 Mar 2

García CCV, Dubeux JCB Jr, Martini X

867. Devising a deep neural network based mammography phantom image filtering algorithm using images obtained under mAs and kVp control.

Sci Rep

2023 Mar 2

Park SS(#), Ku YM(#), Seo KJ

868. Effects of short bout small-sided game training on acid-based balance markers in youth male soccer players.

Sci Rep

2023 Mar 2

Kryściak J, Podgórski T, Chmura P

869. Size distribution and relationship of airborne SARS-CoV-2 RNA to indoor aerosol in hospital ward environments.

Sci Rep

2023 Mar 2

Groma V, Kugler S, Farkas Á

870. Adherence to antiretroviral therapy in people living with HIV with moderate or severe mental disorder.

Sci Rep

2023 Mar 2

Arashiro P, Maciel CG, Freitas FPR

871. An extended Hilbert transform method for reconstructing the phase from an oscillatory signal.

Sci Rep

2023 Mar 2

Matsuki A, Kori H, Kobayashi R.

872. Maleic acid as an important monomer in synthesis of stimuli-responsive poly(acrylic acid-co-acrylamide-co-maleic acid) superabsorbent polymer.

Sci Rep

2023 Mar 2

Jamali F, Etminani-Esfahani N, Rahmati A.

873. A cortical biomarker of audibility and processing efficacy in children with single-sided deafness using a cochlear implant.

Sci Rep

2023 Mar 2

Yaar-Soffer Y(#), Kaplan-Neeman R(#), Greenbom T

874. Novel NF-κB reporter mouse for the non-invasive monitoring of inflammatory diseases.

Sci Rep

2023 Mar 2

Park SY(#), Kim MW(#), Kang JH

875. GRB2 dimerization mediated by SH2 domain-swapping is critical for T cell signaling and cytokine production.

Sci Rep

2023 Mar 2

Sandouk A, Xu Z, Baruah S

876. Diurnal changes in choroidal optical coherence tomography angiography indices over 24 hours in healthy young adults.

Sci Rep

2023 Mar 2

Lal B, Alonso-Caneiro D, Read SA

877. Comparative study of three plant-derived extracts as new management strategies against Spodoptera littoralis (Boisd.) (Lepidoptera: Noctuidae).

Sci Rep

2023 Mar 2

Hussein HS, Salem MZM, Soliman AM

Finding innovative eco-friendly agents for pest control may be aided by investigating the plant-derived extracts' properties on economic pests. Therefore, the insecticidal, behavioral, biological and biochemical effects of Magnolia grandiflora (Magnoliaceae) leaf water and methanol extracts, Schinus terebinthifolius (Anacardiaceae) wood methanol extract, and Salix babylonica (Salicaceae) leaf methanol extract in comparison with a reference insecticide novaluron against S. littoralis were evaluated. The extracts were analyzed by High-Performance Liquid Chromatography (HPLC). The most abundant phenolic compounds were 4-hydroxybenzoic acid (7.16 mg/mL) and ferulic acid (6.34 mg/mL) in M. grandiflora leaf water extract; catechol (13.05 mg/mL), ferulic acid (11.87 mg/mL), and chlorogenic acid (10.33 mg/mL) in M. grandiflora leaf methanol extract; ferulic acid (14.81 mg/mL), caffeic acid (5.61 mg/mL), and gallic acid (5.07 mg/mL) In the S. terebinthifolius extract; cinnamic acid (11.36 mg/mL), and protocatechuic acid (10.33 mg/mL) In the methanol extract from S. babylonica extract. S. terebinthifolius extract had a highly toxic effect against second larvae after 96 h and eggs with LC50 values of 0.89 and 0.94 mg/L, respectively. Despite M. grandiflora extracts didn't show any toxicity against S. littoralis stages, they had an attractant effect on fourth- and second larvae, with feeding deterrence values of - 2.7% and - 6.7%, respectively, at 10 mg/L. S. terebinthifolius extract significantly reduced the percentage of pupation, adult emergence, hatchability, and fecundity, with values of 60.2%, 56.7%, 35.3%, and 105.4 eggs/female, respectively. Novaluron and S. terebinthifolius extract drastically inhibited the activities of α-amylase and total proteases to 1.16 and 0.52, and 1.47 and 0.65 ΔOD/mg protein/min, respectively. In the semi-field experiment, the residual toxicity of tested extracts on S. littoralis gradually decreased over time compared to novaluron. These findings indicate that extract from S. terebinthifolius is a promising insecticidal agent against S. littoralis.

878. Gaze onsets during naturalistic infant-caregiver interaction associate with 'sender' but not 'receiver' neural responses, and do not lead to changes in inter-brain synchrony.

Sci Rep

2023 Mar 2

Marriott Haresign I, Phillips EAM, Whitehorn M

879. Relationship between postpartum depression and plasma vasopressin level at 6-8 weeks postpartum: a cross-sectional study.

Sci Rep

2023 Mar 2

Kashkouli M, Jahanian Sadatmahalleh S, Ziaei S

Postpartum depression (PPD) is the most important postpartum mood disorder due to its significant effect on both the infant and family health. Arginine vasopressin (AVP) has been suggested as a hormonal agent involved in the development of depression. The purpose of this study was to investigate the relationship between the plasma concentrations of AVP and the score of Edinburgh Postnatal Depression Scale (EPDS). This cross-sectional study was conducted in 2016-2017 in Darehshahr Township, Ilam Province, Iran. In the first phase, 303 pregnant women, who were at 38 weeks, met the inclusion criteria, and were not depressed (according to their EPDS scores) were included in the study. In the 6-8 week postpartum follow-up, using the EPDS, 31 depressed individuals were diagnosed and referred to a psychiatrist for confirmation. The maternal venous blood samples of 24 depressed individuals still meeting the inclusion criteria and 66 randomly selected non-depressed subjects were obtained to measure their AVP plasma concentrations with ELISA assay. There was a significant positive relationship between plasma AVP levels and the EPDS score (P = 0.000, r = 0.658). Also the mean plasma concentration of AVP was significantly higher in the depressed group (41.35 ± 13.75 ng/ml) than in the non-depressed group (26.01 ± 7.83 ng/ml) (P < 0.001). In a multiple logistic regression model for various parameters, increased vasopressin levels were associated with increased odds of PPD (OR = 1.15, 95% CI = 1.07-1.24, P = 0.000). Furthermore, multiparity (OR = 5.45, 95% CI = 1.21-24.43, P = 0.027) and non-exclusive breastfeeding (OR = 13.06, 95% CI = 1.36-125, P = 0.026) were associated with increased odds of PPD. Maternal gender preference (having a baby of desired and desired sex) decreased the odds of PPD (OR = 0.13, 95% CI = 0.02-0.79, P = 0.027 and OR = 0.08, 95% CI = 0.01-0.5, P = 0.007). AVP seems to be a contributor to clinical PPD by affecting the hypothalamic-pituitary-adrenal (HPA) axis activity. Furthermore, primiparous women had significantly lower EPDS scores.

880. Green fluorometric strategy for simultaneous determination of the antihypertensive drug telmisartan (A tentative therapeutic for COVID-19) with Nebivolol in human plasma.

Sci Rep

2023 Mar 2

Salim MM, Radwan AS, Hadad GM

881. An anthropometric evidence against the use of age-based estimation of bodyweight in pediatric patients admitted to intensive care units.

Sci Rep

2023 Mar 2

Nosaka N, Anzai T, Uchimido R

882. Temperature dependence of nitrogen solubility in bridgmanite and evolution of nitrogen storage capacity in the lower mantle.

Sci Rep

2023 Mar 2

Fukuyama K, Kagi H, Inoue T

883. High-precision angle adaptive control simulation of synchronous motor for automatic lifting and boarding equipment of aircraft platform.

Sci Rep

2023 Mar 2

Zhang Z.

884. In silico design of a polypeptide as a vaccine candidate against ascariasis.

Sci Rep

2023 Mar 2

Evangelista FMD, van Vliet AHM, Lawton SP

885. The role of the west-dipping collision boundary fault in the Taiwan 2022 Chihshang earthquake sequence.

Sci Rep

2023 Mar 2

Lee SJ, Liu TY, Lin TC.

886. Diffusion tensor imaging metrics associated with future disability in multiple sclerosis.

Sci Rep

2023 Mar 2

Lopez-Soley E(#), Martinez-Heras E(#), Solana E(#)

887. Photodegradation of a bacterial pigment and resulting hydrogen peroxide release enable coral settlement.

Sci Rep

2023 Mar 2

Petersen LE(#), Kellermann MY(#), Fiegel LJ

888. Pediatric chronic graft-versus-host disease-related dry eye disease and the diagnostic association of potential clinical findings.

Sci Rep

2023 Mar 2

Yagi H, Shimizu E, Yagi R

889. Statistical evidence for the contribution of citizen-led initiatives and projects to the energy transition in Europe.

Sci Rep

2023 Mar 2

Schwanitz VJ, Wierling A, Arghandeh Paudler H

890. A novel designed membrane-active peptide for the control of foodborne Salmonella enterica serovar Typhimurium.

Sci Rep

2023 Mar 2

Sengkhui S, Klubthawee N, Aunpad R.

891. An innovative wireless electrochemical card sensor for field-deployable diagnostics of Hepatitis B surface antigen.

Sci Rep

2023 Mar 2

Teengam P, Tangkijvanich P, Chuaypen N

892. Numerical exploration of forced convection hydromagnetic hyperbolic tangent nanofluid flow over a permeable wedge with melting heat transfer.

Sci Rep

2023 Mar 2

Endalew MF, Sarkar S.

893. Comparative phylogenomic insights of KCS and ELO gene families in Brassica species indicate their role in seed development and stress responsiveness.

Sci Rep

2023 Mar 2

Khan UM(#), Rana IA(#), Shaheen N

Very long-chain fatty acids (VLCFAs) possess more than twenty carbon atoms and are the major components of seed storage oil, wax, and lipids. FAE (Fatty Acid Elongation) like genes take part in the biosynthesis of VLCFAs, growth regulation, and stress responses, and are further comprised of KCS (Ketoacyl-CoA synthase) and ELO (Elongation Defective Elongase) sub-gene families. The comparative genome-wide analysis and mode of evolution of KCS and ELO gene families have not been investigated in tetraploid Brassica carinata and its diploid progenitors. In this study, 53 KCS genes were identified in B. carinata compared to 32 and 33 KCS genes in B. nigra and B. oleracea respectively, which suggests that polyploidization might has impacted the fatty acid elongation process during Brassica evolution. Polyploidization has also increased the number of ELO genes in B. carinata (17) over its progenitors B. nigra (7) and B. oleracea (6). Based on comparative phylogenetics, KCS, and ELO proteins can be classified into eight and four major groups, respectively. The approximate date of divergence for duplicated KCS and ELO genes varied from 0.03 to 3.20 million years ago (MYA). Gene structure analysis indicated that the maximum number of genes were intron-less and remained conserved during evolution. The neutral type of selection seemed to be predominant in both KCS and ELO genes evolution. String-based protein-protein interaction analysis suggested that bZIP53, a transcription factor might be involved in the activation of transcription of ELO/KCS genes. The presence of biotic and abiotic stress-related cis-regulatory elements in the promoter region suggests that both KCS and ELO genes might also play their role in stress tolerance. The expression analysis of both gene family members reflect their preferential seed-specific expression, especially during the mature embryo development stage. Furthermore, some KCS and ELO genes were found to be specifically expressed under heat stress, phosphorus starvation, and Xanthomonas campestris infection. The current study provides a basis to understand the evolution of both KCS and ELO genes in fatty acid elongation and their role in stress tolerance.

894. Inflammatory stimuli induce shedding of heparan sulfate from arterial but not venous porcine endothelial cells leading to differential proinflammatory and procoagulant responses.

Sci Rep

2023 Mar 18

Milusev A, Despont A, Shaw J

895. Extraction, structural characterization, and biological activities of a new glucan from Codonopsis pilosula.

Sci Rep

2023 Mar 18

Lu S, Gu W, Ma Q

896. Enhancing earthquake preparedness knowledge and practice among Nepalese immigrants residing in Japan.

Sci Rep

2023 Mar 18

Bhandari AKC, Rahman M, Takahashi O.

897. Remdesivir and corticosteroids in the treatment of hospitalized COVID-19 patients.

Sci Rep

2023 Mar 18

Coelho L, Falcão F, Póvoa P

898. Taming hyperparameter tuning in continuous normalizing flows using the JKO scheme.

Sci Rep

2023 Mar 18

Vidal A, Wu Fung S, Tenorio L

899. MR-guided ultrasound-stimulated microbubble therapy enhances radiation-induced tumor response.

Sci Rep

2023 Mar 18

McNabb E, Sharma D, Sannachi L

High intensity focused ultrasound (HIFU) systems have been approved for therapeutic ultrasound delivery to cause tissue ablation or induced hyperthermia. Microbubble agents have also been used in combination with sonication exposures. These require temperature feedback and monitoring to prevent unstable cavitation and prevent excess tissue heating. Previous work has utilized lower power and pressure to oscillate microbubbles and transfer energy to endothelial cells in the absence of thermally induced damage that can radiosensitize tumors. This work investigated whether reduced acoustic power and pressure on a commercial available MR-integrated HIFU system could result in enhanced radiation-induced tumor response after exposure to ultrasound-stimulated microbubbles (USMB) therapy. A commercially available MR-integrated HIFU system was used with a hyperthermia system calibration provided by the manufacturer. The ultrasound transducer was calibrated to reach a peak negative pressure of - 750 kPa. Thirty male New Zealand white rabbits bearing human derived PC3 tumors were grouped to receive no treatment, 14 min of USMB, 8 Gy of radiation in a separate irradiation cabinet, or combined treatments. In vivo temperature changes were collected using MR thermometry at the tumor center and far-field muscle region. Tissues specimens were collected 24 h post radiation therapy. Tumor cell death was measured and compared to untreated controls through hematoxylin and eosin staining and immunohistochemical analysis. The desired peak negative pressure of - 750 kPa used for previous USMB occurred at approximately an input power of 5 W. Temperature changes were limited to under 4 °C in ten of twelve rabbits monitored. The median temperature in the far-field muscle region of the leg was 2.50 °C for groups receiving USMB alone or in combination with radiation. Finally, statistically significant tumor cell death was demonstrated using immunohistochemical analysis in the combined therapy group compared to untreated controls. A commercial MR-guided therapy HIFU system was able to effectively treat PC3 tumors in a rabbit model using USMB therapy in combination with radiation exposures. Future work could find the use of reduced power and pressure levels in a commercial MR-guided therapy system to mechanically stimulate microbubbles and damage endothelial cells without requiring high thermal doses to elicit an antitumor response.

900. In-field assessment of change-of-direction ability with a single wearable sensor.

Sci Rep

2023 Mar 18

Apte S, Karami H, Vallat C

901. Using disproportionality analysis to explore the association between periostitis and triazole antifungals in the FDA Adverse Event Reporting System Database.

Sci Rep

2023 Mar 18

Li H, Zhang M, Jiao X

902. Metal-tolerant and siderophore producing Pseudomonas fluorescence and Trichoderma spp. improved the growth, biochemical features and yield attributes of chickpea by lowering Cd uptake.

Sci Rep

2023 Mar 18

Syed A, Elgorban AM, Bahkali AH

Industrialization and human urbanization have led to an increase in heavy metal (HM) pollution which often cause negative/toxic effect on agricultural crops. The soil-HMs cannot be degraded biologically however, microbe-mediated detoxification of toxic HMs into lesser toxic forms are reported. Considering the potentiality of HMs-tolerant soil microbes in metal detoxification, Pseudomonas fluorescence PGPR-7 and Trichoderma sp. T-4 were recovered from HM-affected areas. Under both normal and cadmium stress, the ability of both microorganisms to produce different plant hormones and biologically active enzymes was examined. Strains PGPR-7 and T-4 tolerated cadmium (Cd) an up-to 1800 and 2000 µg mL-1, respectively, and produced various plant growth regulating substances (IAA, siderophore, ACC deaminase ammonia and HCN) in Cd-stressed condition. The growth promoting and metal detoxifying ability of both strains were evaluated (either singly/combined) by applying them in chickpea (Cicer arietinum L.) plants endogenously contaminated with different Cd levels (0-400 µg kg-1 soils). The higher Cd concentration (400 µg kg-1 soils) negatively influenced the plant parameters which, however, improved following single/combined inoculation of P. fluorescence PGPR-7 and Trichoderma sp. T-4. Both microbial strains increased the growth of Cd-treated chickpeas however, their combined inoculation (PGPR-7 + T-4) caused the most positive effect. For instance, 25 µg Cd Kg-1 + PGPR-7 + T4 treatment caused maximum increase in germination percentage (10%), root dry biomass (71.4%) and vigour index (33%), chl-a (38%), chl-b (41%) and carotenoid content (52%). Furthermore, combined inoculation of P. fluorescence PGPR-7 and Trichoderma sp. T-4 maximally decreased the proline, MDA content, POD and CAT activities by 50%, 43% and 62%, respectively following their application in 25 µg Cd kg-1 soils-treated chickpea. Additionally, microbial strains lowered the plant uptake of Cd. For example, Cd-uptake in root tissues was decreased by 42 and 34% when 25 µg Cd Kg-1- treated chickpea plants were inoculated with P. fluorescence PGPR-7, Trichoderma sp. T-4 and co-inoculation (PGPR-7 + T4) of both strains, respectively. Therefore, from the current observation, it is suggested that dual inoculation of metal tolerant P. fluorescence and Trichoderma sp. may potentially be used in detoxification and reclamation of metal-contaminated soils.

903. Molecular cloning, characterization and 3D modelling of spotted snakehead fbn1 C-terminal region encoding asprosin and expression analysis of fbn1.

Sci Rep

2023 Mar 18

Sathoria P, Chuphal B, Rai U

904. Pollinator sex matters in competition and coexistence of co-flowering plants.

Sci Rep

2023 Mar 18

Nakazawa T, Kishi S.

905. Tranexamic acid for the prevention of postpartum haemorrhage: the TAPPH-1 pilot randomized trial and lessons learned for trials in Canadian obstetrics.

Sci Rep

2023 Mar 18

Alam AQ, Barrett J, Callum J

906. Multiparameter prediction model of immune checkpoint inhibitors combined with chemotherapy for non-small cell lung cancer based on support vector machine learning.

Sci Rep

2023 Mar 18

Zhou Z, Guo W, Liu D

907. Prevalence of asthma in preterm and associated risk factors based on prescription data from the Korean National Health Insurance database.

Sci Rep

2023 Mar 18

Kim K, Lee JY, Kim YM

908. Development and validation of a simple machine learning tool to predict mortality in leptospirosis.

Sci Rep

2023 Mar 18

Galdino GS, de Sandes-Freitas TV, de Andrade LGM

909. The use of benzodiazepines and the mental health of women in prison: a cross-sectional study.

Sci Rep

2023 Mar 18

Miranda Seixas Einloft F, Kopittke L, Thais Guterres Dias M

910. Bioinformatics analysis of rheumatoid arthritis tissues identifies genes and potential drugs that are expressed specifically.

Sci Rep

2023 Mar 18

He Q, Ding H.

911. CRISPR-Cas9 editing of TLR4 to improve the outcome of cardiac cell therapy.

Sci Rep

2023 Mar 18

Schary Y, Rotem I, Caller T

912. Urinary exosomal miRNA-663a shows variable expression in diabetic kidney disease patients with or without proteinuria.

Sci Rep

2023 Mar 18

Sinha N, Puri V, Kumar V

913. Effects of short-term PM(2.5) exposure on blood lipids among 197,957 people in eastern China.

Sci Rep

2023 Mar 18

Liu Q(#), Wang Z(#), Lu J(#)

Globally, air pollution is amongst the most significant causes of premature death. Nevertheless, studies on the relationship between fine particulate matter (PM2.5) exposure and blood lipids have typically not been population-based. In a large, community-based sample of residents in Yixing city, we assessed the relationship between short-term outdoor PM2.5 exposure and blood lipid concentrations. Participants who attended the physical examination were enrolled from Yixing People's hospital from 2015 to 2020. We collected general characteristics of participants, including gender and age, as well as test results of indicators of blood lipids. Data on daily meteorological factors were collected from the National Meteorological Data Sharing Center ( http://data.cma.cn/ ) and air pollutant concentrations were collected from the China Air Quality Online Monitoring and Analysis Platform ( https://www.aqistudy.cn/ ) during this period. We applied generalized additive models to estimate short-term effects of ambient PM2.5 exposure on each measured blood lipid-related indicators and converted these indicators into dichotomous variables (non- hyperlipidemia and hyperlipidemia) to calculate risks of hyperlipidemia associated with PM2.5 exposure. A total of 197,957 participants were included in the analysis with mean age 47.90 years (± SD, 14.28). The increase in PM2.5 was significantly associated with hyperlipidemia (odds ratio (OR) 1.003, 95% CI 1.001-1.004), and it was still significant in subgroups of males and age < 60 years. For every 10 μg/m3 increase in PM2.5, triglyceride levels decreased by 0.5447% (95% CI - 0.7873, - 0.3015), the low-density lipoprotein cholesterol concentration increased by 0.0127 mmol/L (95% CI 0.0099, 0.0156), the total cholesterol concentration increased by 0.0095 mmol/L (95% CI 0.0053, 0.0136), and no significant association was observed between PM2.5 and the high-density lipoprotein cholesterol concentration. After excluding people with abnormal blood lipid concentrations, the associations remained significant except for the high-density lipoprotein cholesterol concentration. PM2.5 was positively correlated with low-density lipoprotein cholesterol and total cholesterol, and negatively correlated with triglyceride, indicating PM2.5 can potentially affect health through blood lipid levels.

914. Clinical features predictive of vision loss in patients with vitreoretinal lymphoma: a single tertiary center experience.

Sci Rep

2023 Mar 18

Kim M, Suh H, Park YG

915. The PaleoJump database for abrupt transitions in past climates.

Sci Rep

2023 Mar 18

Bagniewski W, Rousseau DD, Ghil M.

916. Deep learning pose estimation for multi-cattle lameness detection.

Sci Rep

2023 Mar 18

Barney S, Dlay S, Crowe A

The objective of this study was to develop a fully automated multiple-cow real-time lameness detection system using a deep learning approach for cattle detection and pose estimation that could be deployed across dairy farms. Utilising computer vision and deep learning, the system can analyse simultaneously both the posture and gait of each cow within a camera field of view to a very high degree of accuracy (94-100%). Twenty-five video sequences containing 250 cows in varying degrees of lameness were recorded and independently scored by three accredited Agriculture and Horticulture Development Board (AHDB) mobility scorers using the AHDB dairy mobility scoring system to provide ground truth lameness data. These observers showed significant inter-observer reliability. Video sequences were broken down into their constituent frames and with a further 500 images downloaded from google, annotated with 15 anatomical points for each animal. A modified Mask-RCNN estimated the pose of each cow to output 5 key-points to determine back arching and 2 key-points to determine head position. Using the SORT (simple, online, and real-time tracking) algorithm, cows were tracked as they move through frames of the video sequence (i.e., in moving animals). All the features were combined using the CatBoost gradient boosting algorithm with accuracy being determined using threefold cross-validation including recursive feature elimination. Precision was assessed using Cohen's kappa coefficient and assessments of precision and recall. This methodology was applied to cows with varying degrees of lameness (according to accredited scoring, n = 3) and demonstrated that some characteristics directly associated with lameness could be monitored simultaneously. By combining the algorithm results over time, more robust evaluation of individual cow lameness was obtained. The model showed high performance for predicting and matching the ground truth lameness data with the outputs of the algorithm. Overall, threefold lameness detection accuracy of 100% and a lameness severity classification accuracy of 94% respectively was achieved with a high degree of precision (Cohen's kappa = 0.8782, precision = 0.8650 and recall = 0.9209).

917. The design of a point of care FET biosensor to detect and screen COVID-19.

Sci Rep

2023 Mar 18

Alnaji N, Wasfi A, Awwad F.

918. Collagen constitutes about 12% in females and 17% in males of the total protein in mice.

Sci Rep

2023 Mar 18

Tarnutzer K, Siva Sankar D, Dengjel J

919. Preparation and characterization of low-cost adsorbents for the efficient removal of malachite green using response surface modeling and reusability studies.

Sci Rep

2023 Mar 18

Moustafa MT.

920. Antioxidant and hypoglycemic potential of phytogenic cerium oxide nanoparticles.

Sci Rep

2023 Mar 18

Khan M, Sohail, Raja NI

921. Assessing compatibility and viral fitness between poultry-adapted H9N2 and wild bird-derived neuraminidases.

Sci Rep

2023 Mar 18

Wasberg A, Faria IR, Bergholm J

922. Ultrasensitive tapered optical fiber refractive index glucose sensor.

Sci Rep

2023 Mar 18

Ujah E(#), Lai M(#), Slaughter G.

923. Moderation effects of loneliness between fatalism and wellbeing during the COVID-19 pandemic.

Sci Rep

2023 Mar 18

Miranda Ayala R, Torrelles-Nadal C, Magro Lazo G

924. The effect of SARS-CoV-2 variant on respiratory features and mortality.

Sci Rep

2023 Mar 18

Hughes TD(#), Subramanian A(#), Chakraborty R

925. Biomimetic ion substituted and Co-substituted hydroxyapatite nanoparticle synthesis using Serratia Marcescens.

Sci Rep

2023 Mar 18

Paramasivan M, Sampath Kumar TS, Kanniyappan H

Biomimicry is becoming deep-rooted as part of bioceramics owing to its numerous functional advantages. Naturally occurring hydroxyapatite (HA) apart from primary nano structures are also characterised by various ionic substitutions. The ease of accommodating such key elements into the HA lattice is known to enhance bone healing properties of bioceramics. In this work, hydroxyapatite synthesized via biomimetic approach was substituted with individual as well as multiple cations for potential applications in bone repair. Ion substitutions of Sr, Mg and Zn was carried out on HA for the first time by using Serratia grown in a defined biomineralization medium. The individual ions of varying concentration substituted in Serratia HA (SHA) (Sr SHA, Mg SHA and Zn SHA) were analysed for crystallinity, functional groups, morphology and crystal size. All three showed decreased crystallinity, phase purity, large agglomerated aggregates and needle-shaped morphologies. Fourier transform infrared spectroscopy (FTIR) spectra indicated increased carbonate content of 5.8% resembling that of natural bone. Additionally, the reduced O-H intensities clearly portrayed disruption of HA lattice and subsequent ion-substitution. The novelty of this study lies primarily in investigating the co-substitution of a combination of 1% Sr, Zn and Mg in SHA and establishing the associated change in bone parameters. Scanning electron microscope (SEM) and transmission electron microscope (TEM) images clearly illustrated uniform nano-sized agglomerates of average dimensions of 20-50 nm length and 8-15 nm width for Sr SHA; 10-40 nm length and 8-10 nm width for both Zn SHA and Mg SHA and 40-70 nm length and 4-10 nm width in the case of 1% Sr, Zn, Mg SHA. In both individual as well as co-substitutions, significant peak shifts were not observed possibly due to the lower concentrations. However, cell volumes increased in both cases due to presence of Sr2+ validating its dominant integration into the SHA lattice. Rich trace ion deposition was presented by energy dispersive X-ray spectroscopy (EDS) and quantified using inductively coupled plasma optical emission spectrometer (ICP-OES). In vitro cytotoxicity studies in three cell lines viz. NIH/3T3 fibroblast cells, MG-63 osteosarcoma cells and RAW 264.7 macrophages showed more than 90% cell viability proving the biocompatible nature of 1% Sr, Zn and Mg in SHA. Microbial biomineralization by Serratia produced nanocrystals of HA that mimicked "bone-like apatite" as evidenced by pure phase, carbonated groups, reduced crystallinity, nano agglomerates, variations in cell parameters, rich ion deposition and non-toxic nature. Therefore ion-substituted and co-substituted biomineralized nano SHA appears to be a suitable candidate for applications in biomedicine addressing bone injuries and aiding regeneration as a result of its characteristics close to that of the human bone.

926. Elamipretide mitigates ischemia-reperfusion injury in a swine model of hemorrhagic shock.

Sci Rep

2023 Mar 18

Patel N, Johnson MA, Vapniarsky N

927. Influence of gamma irradiation on rosin properties and its antimicrobial activity.

Sci Rep

2023 Mar 18

Badr MM, Awadallah-F A, Azzam AM

928. Microbial diversity and metabolic function in duodenum, jejunum and ileum of emu (Dromaius novaehollandiae).

Sci Rep

2023 Mar 18

Kim JE, Tun HM, Bennett DC

Emus (Dromaius novaehollandiae), a large flightless omnivorous ratite, are farmed for their fat and meat. Emu fat can be rendered into oil for therapeutic and cosmetic use. They are capable of gaining a significant portion of its daily energy requirement from the digestion of plant fibre. Despite of its large body size and low metabolic rate, emus have a relatively simple gastroinstetinal (GI) tract with a short mean digesta retention time. However, little is known about the GI microbial diversity of emus. The objective of this study was to characterize the intraluminal intestinal bacterial community in the different segments of small intestine (duodenum, jejunum, and ileum) using pyrotag sequencing and compare that with the ceca. Gut content samples were collected from each of four adult emus (2 males, 2 females; 5-6 years old) that were free ranged but supplemented with a barley-alfalfa-canola based diet. We amplified the V3-V5 region of 16S rRNA gene to identify the bacterial community using Roche 454 Junior system. After quality trimming, a total of 165,585 sequence reads were obtained from different segments of the small intestine (SI). A total of 701 operational taxonomic units (OTUs) were identified in the different segments of small intestine. Firmicutes (14-99%) and Proteobacteria (0.5-76%) were the most predominant bacterial phyla in the small intestine. Based on species richness estimation (Chao1 index), the average number of estimated OTUs in the small intestinal compartments were 148 in Duodenum, 167 in Jejunum, and 85 in Ileum, respectively. Low number of core OTUs identified in each compartment of small intestine across individual birds (Duodenum: 13 OTUs, Jejunum: 2 OTUs, Ileum: 14 OTUs) indicated unique bacterial community in each bird. Moreover, only 2 OTUs (Escherichia and Sinobacteraceae) were identified as core bacteria along the whole small intestine. PICRUSt analysis has indicated that the detoxification of plant material and environmental chemicals seem to be performed by SI microbiota, especially those in the jejunum. The emu cecal microbiome has more genes than SI segments involving in protective or immune response to enteric pathogens. Microbial digestion and fermentation is mostly in the jejunum and ceca. This is the first study to characterize the microbiota of different compartments of the emu intestines via gut samples and not fecal samples. Results from this study allow us to further investigate the influence of the seasonal and physiological changes of intestinal microbiota on the nutrition of emus and indirectly influence the fatty acid composition of emu fat.

929. Lightweight saliency detection method for real-time localization of livestock meat bones.

Sci Rep

2023 Mar 18

Xu T, Zhao W, Cai L

930. Exploring the entropic nature of political polarization through its formulation as a isolated thermodynamic system.

Sci Rep

2023 Mar 17

Mantzaris AV, Domenikos GR.

931. Testing the morphological constraint hypothesis of tail length in the sexually dimorphic Cerastes vipera and new perspectives.

Sci Rep

2023 Mar 17

Sivan J, Tesler I, Hadad S

932. Sustainable application of calcium carbide residue as a filler for 3D printing materials.

Sci Rep

2023 Mar 17

Samoylenko DE, Rodygin KS, Ananikov VP.

933. Fuzzy optimal control of multilayer coverage based on radon exhalation dynamics in uranium tailings.

Sci Rep

2023 Mar 17

Zhang M, Dai J.

934. Fabrication of nitrogen doped TiO(2)/Fe(2)O(3) nanostructures for photocatalytic oxidation of methanol based wastewater.

Sci Rep

2023 Mar 17

Mersal M, Zedan AF, Mohamed GG

935. Cleaner production of essential oils from Indian basil, lemongrass and coriander leaves using ultrasonic and ohmic heating pre-treatment systems.

Sci Rep

2023 Mar 17

Kumar R(#), Chopra S(#), Choudhary AK(#)

936. Clinical evaluation of DIAGNOVIR SARS-CoV-2 ultra-rapid antigen test performance compared to PCR-based testing.

Sci Rep

2023 Mar 17

Seymen AA(#), Gulten E(#), Ozgur E(#)

937. Information set supported deep learning architectures for improving noisy image classification.

Sci Rep

2023 Mar 17

Bhardwaj S, Wang Y, Yu G

938. An insight into the microphysical attributes of northwest Pacific tropical cyclones.

Sci Rep

2023 Mar 17

Seela BK(#), Janapati J(#), Lin PL

939. Practical overview of image classification with tensor-network quantum circuits.

Sci Rep

2023 Mar 17

Guala D, Zhang S, Cruz E

940. Catalytic response and molecular simulation studies in the development of synthetic routes in trimeric triaryl pyridinium type ionic liquids.

Sci Rep

2023 Mar 17

Tamilarasan R, Subramani A, Sasikumar G

941. Revealing the impact of organic spacers and cavity cations on quasi-2D perovskites via computational simulations.

Sci Rep

2023 Mar 17

Guedes-Sobrinho D, Neves Silveira D, de Araujo LO

942. The development and evaluation of an in-vitro shoulder simulator with active muscle simulation.

Sci Rep

2023 Mar 17

Guo R, Ferle M, Nebel D

The purpose of the present study was to develop a novel active in-vitro shoulder simulator to emulate all forms of planar and non-planar glenohumeral motions with active muscle simulation on cadaver specimens or shoulder models and to critically evaluate its performance. A physiologic shoulder simulator, driven using simulated muscle force, was developed to dynamically realize accurate kinematic control in all three rotational degrees of freedom (DOF) under physiological kinetic boundaries. The control algorithm of the simulator was implemented using three parallel running independent control loops, which regulate the forces of individual muscles in the respect DOF and work asynchronously in disparate sequences adapted to specific motions (abduction, flexion/extension and rotation). Three cadaveric specimens were used to evaluate the kinematic and kinetic performance of the simulator during simulated motions. High kinematic accuracy (maximum mean deviation ≤ 2.35° and RMSE 1.13°) and repeatability (maximum and average SD of ≤ 1.21° and 0.67°) were observed in all three rotational DOF investigated. The reliabilities of all individual muscle forces actuated in the simulator during planar and non-planar motions were generally excellent, with the 95% CIs of ICC estimates of > 0.90 for most instances (30/36). A novel shoulder simulator with active muscle simulation was developed and evaluated. Its capability to reproduce kinematics and kinetics in a physiological range for all DOF was systematically evaluated for multiple kinetic and kinematic outcome variables. The presented simulator is a powerful tool for investigating the biomechanics of physiological and pathological shoulder joints and to evaluate various surgical interventions. Acquisition of reliable data in joint kinetics and translational kinematics during active motions is critical to assess shoulder pathologies and appropriate treatments. We provide a unique muscle activated physiologic shoulder simulator, which allows the comprehensive acquisition of joint kinematic and kinetic data during repeated realistic planar and non-planar motions.

943. An epidemiological study on skin tumors of the elderly in a community in Shanghai, China.

Sci Rep

2023 Mar 17

Huang J(#), Zhang L(#), Shi L

944. Severity and geographical disparities of post-COVID-19 symptoms among the Vietnamese general population: a national evaluation.

Sci Rep

2023 Mar 17

Tran B, Le Vu MN, Le HT

945. Numerical investigation of the effect of fluid pressurization rate on laboratory-scale injection-induced fault slip.

Sci Rep

2023 Mar 17

Hutka GA, Cacace M, Hofmann H

The effect of normal stress variations on fault frictional strength has been extensively characterized in laboratory experiments and modelling studies based on a rate-and-state-dependent fault friction formalism. However, the role of pore pressure changes during injection-induced fault reactivation and associated frictional phenomena is still not well understood. We apply rate-and-state friction (RSF) theory in finite element models to investigate the effect of fluid pressurization rate on fault (re)activation and on the resulting frictional slip characteristics at the laboratory scale. We consider a stepwise injection scenario where each fluid injection cycle consists of a fluid pressurization phase followed by a constant fluid pressure phase. We first calibrate our model formulation to recently published laboratory results of injection-driven shear slip experiments. In a second stage, we perform a parametric study by varying fluid pressurization rates to cover a higher dimensional parameter space. We demonstrate that, for high permeability laboratory samples, the energy release rate associated with fault reactivation can be effectively controlled by a stepwise fluid injection scheme, i.e. by the applied fluid pressurization rate and the duration of the constant pressure phase between each successive fluid pressurization phase. We observe a gradual transition from fault creep to slow stick-slip as the fluid pressurization rate increases. Furthermore, computed peak velocities for an extended range of fluid pressurization rate scenarios (0.5 MPa/min to 10 MPa/min) indicate a non-linear (power-law) relationship between the imposed fluid pressurization rate and the peak slip velocities, and consequently with the energy release rate, for scenarios with a fluid pressurization rate higher than a critical value of 4 MPa/min. We also observe that higher pressurization rates cause a delay in the stress release by the fault. We therefore argue that by adopting a stepwise fluid injection scheme with lower fluid pressurization rates may provide the operator with a better control over potential induced seismicity. The implications for field-scale applications that we can derive from our study are limited by the high matrix and fault permeability of the selected sample and the direct hydraulic connection between the injection well and the fault, which may not necessarily represent the conditions typical for fracture dominated deep geothermal reservoirs. Nevertheless, our results can serve as a basis for further laboratory experiments and field-scale modelling studies focused on better understanding the impact of stepwise injection protocols on fluid injection-induced seismicity.

946. Assessing the relative impacts and economic costs of Japanese knotweed management methods.

Sci Rep

2023 Mar 17

Hocking S, Toop T, Jones D

947. Occurrence and patterns of fin whale songs reveal alternative migration strategies in Svalbard Islands, Norway.

Sci Rep

2023 Mar 17

Papale E, Pelagatti M, Pedrazzi G

948. Neuromodulatory effect of 4-(methylthio)butyl isothiocyanate against 3-nitropropionic acid induced oxidative impairments in human dopaminergic SH-SY5Y cells via BDNF/CREB/TrkB pathway.

Sci Rep

2023 Mar 17

Kaur P, Attri S, Singh D

Mitochondrial impairment, energetic crisis and elevated oxidative stress have been demonstrated to play a pivotal role in the pathological processes of Huntington's disease (HD). 3-Nitropropionic acid (3-NPA) is a natural neurotoxin that mimics the neurological dysfunctions, mitochondrial impairments and oxidative imbalance of HD. The current investigation was undertaken to demonstrate the neuroprotective effect of 4-(methylthio)butyl isothiocyanate (4-MTBITC) against the 3-NPA induced neurotoxicity in human dopaminergic SH-SY5Y cells. The experimental evidence of oxidative DNA damage by 3-NPA was elucidated by pBR322 DNA nicking assay. In contrast, the 4-MTBITC considerably attenuated the DNA damage, suggesting its free radical scavenging action against 3-NPA and Fenton's reagent. The dose and time-dependent increase of 3-NPA revealed its neurotoxic dose as 0.5 mM after 24 h of treatment of SH-SY5Y cells in MTT assay. In order to determine the optimal dose at which 4-MTBITC protects cell death, the 3-NPA (IC50) induced cells were pretreated with different concentrations of 4-MTBITC for 1 h. The neuroprotective dose of 4-MTBITC against 3-NPA was found to be 0.25 μM. Additionally, the elevated GSH levels in cells treated with 4-MTBITC indicate its propensity to eliminate reactive species generated as a result of 3-NPA-induced mitochondrial dysfunction. Likewise, it was determined through microscopic and flow cytometric experiments that 3-NPA's induced overproduction of reactive species and a decline in mitochondrial membrane potential (MMP) could be efficiently prevented by pre-treating cells with 4-MTBITC. To elucidate the underlying molecular mechanism, the RT-qPCR analysis revealed that the pre-treatment of 4-MTBITC effectively protected neuronal cells against 3-NPA-induced cell death by preventing Caspase-3 activation, Brain-derived neurotrophic factor (BDNF) upregulation, activation of cAMP response element-binding protein (CREB) and Nrf2 induction. Together, our findings lend credence to the idea that pre-treatment with 4-MTBITC reduced 3-NPA-induced neurotoxicity by lowering redox impairment, apoptotic state, and mitochondrial dysfunction. The present work, in conclusion, presented the first proof that the phytoconstituent 4-MTBITC supports the antioxidant system, BDNF/TrkB/CREB signaling, and neuronal survival in dopaminergic SH-SY5Y cells against 3-NPA-induced oxidative deficits.

949. On the nature of the interlayer magnetic interactions in biphase ferromagnetic films.

Sci Rep

2023 Mar 17

Silva EF, Gamino M, Oliveira AB

950. Long-term concentration of tropical forest nutrient hotspots is generated by a central-place apex predator.

Sci Rep

2023 Mar 17

de Miranda EBP, Peres CA, Oliveira-Santos LGR

951. Maximizing biodiesel production from waste cooking oil with lime-based zinc-doped CaO using response surface methodology.

Sci Rep

2023 Mar 17

Weldeslase MG, Benti NE, Desta MA

952. The broad scale impact of climate change on planning aerial wildlife surveys with drone-based thermal cameras.

Sci Rep

2023 Mar 17

Camacho AM, Perotto-Baldivieso HL, Tanner EP

953. Improved GNSS integer ambiguity resolution method based on the column oriented Cholesky decomposition.

Sci Rep

2023 Mar 17

Jiao Y, Li K, Tian C

954. Effect of propolis on mood, quality of life, and metabolic profiles in subjects with metabolic syndrome: a randomized clinical trial.

Sci Rep

2023 Mar 17

Sajjadi SS, Bagherniya M, Soleimani D

955. Evaluation of pre-processing methods for tear fluid proteomics using proximity extension assays.

Sci Rep

2023 Mar 17

Vergouwen DPC, Schotting AJ, Endermann T

956. Photochemical advanced oxidative process treatment effect on the pesticide residues reduction and quality changes in dried red peppers.

Sci Rep

2023 Mar 17

Bae JY(#), Lee DY(#), Oh KY

957. Blockchain enabled data security in vehicular networks.

Sci Rep

2023 Mar 17

Sehar NU(#), Khalid O(#), Khan IA(#)

958. Micro-CT-derived ventilation biomarkers for the longitudinal assessment of pathology and response to therapy in a mouse model of lung fibrosis.

Sci Rep

2023 Mar 17

Pennati F, Leo L, Ferrini E

959. Biomechanical comparison of four triangular osteosynthesis fixations for unilateral vertical sacral fractures.

Sci Rep

2023 Mar 17

Ma Y, Zhao Y, Hong H

960. Hiat1 as a new transporter involved in ammonia regulation.

Sci Rep

2023 Mar 17

Fehsenfeld S, Quijada-Rodriguez AR, Zhouyao H

961. Identification of an immunogenic cell death-related gene signature predicts survival and sensitivity to immunotherapy in clear cell renal carcinoma.

Sci Rep

2023 Mar 17

Zhou S, Lu Y, Chen Y

Immunogenic cell death (ICD) is the trigger of adaptive immune responses. However, the role of ICD-related genes in clear cell renal carcinoma (ccRCC) remains unclear. We aimed to identify biomarkers associated with ICD and develop an ICD-related predictive model that predicts the immune microenvironment, prognosis, and response to immunotherapy in ccRCC. Our study included 739 patients (603 in the training set and 136 in the validation set) with clinicopathologic information and transcriptome sequencing data. Consensus clustering, principal component analysis (PCA), weighted gene co-expression network analysis (WGCNA), univariate COX analysis, multivariate COX analysis, and the Lasso-Cox algorithm were applied to shrink predictors and construct a predictive signature of overall survival (OS). We used CIBERSORT, ESTIMATE, and TIMER in the R package IOBR to evaluate the tumor microenvironment and immune infiltration pattern of each sample. Finally, the single cell sequencing results of immune cells in ccRCC were used to verify the results of immune infiltration analysis, and the performance of the prognostic model was evaluated by calibration curves and c-index. This study revealed that inability of the initial immune response and primary immunodeficiency were significantly enriched in the ICD subgroup with poor prognosis. We found that the ten candidate ICD genes (CALR, ENTPD1, FOXP3, HSP90AA1, IFNB1, IFNG, IL6, LY96, PIK3CA, and TLR4) could affect the prognosis of ccRCC (p < 0.05). The prediction model (PRE) we constructed can not only predict the long-term survival probability but also evaluate the landscape of immune infiltration in ccRCC. Our study demonstrated that low infiltration of dendritic cells in ccRCC implies a poor prognosis, whereas the degree of CTL infiltration is less important. An individualized prediction model was created to predict the 1-, 2-, 3-, and 5-year survival and responsiveness of ccRCC patients to immunotherapy, which may serve as a potent tool for clinicians to make better treatment decisions and thus improve the overall survival (OS) of ccRCC patients in the future.

962. Virulence analysis and antibiotic resistance of Klebsiella pneumoniae isolates from hospitalised patients in Poland.

Sci Rep

2023 Mar 17

Kot B, Piechota M, Szweda P

963. Increased cardiac involvement in Fabry disease using blood-corrected native T1 mapping.

Sci Rep

2023 Mar 17

Nickander J, Cole B, Nordin S

964. The influence of Cenozoic Eurasia-Arabia convergence on the Southeast Arabian Foreland Basin: new geochronological and geochemical constraints from syn-kinematic carbonate mineralization.

Sci Rep

2023 Mar 16

Arboit F, Drost K, Decarlis A

965. Palliative care and healthcare utilization among metastatic breast cancer patients in U.S. Hospitals.

Sci Rep

2023 Mar 16

Kim SJ, Patel I, Park C

966. Liver tissues oxidative status, epigenetic and molecular characteristics in rats administered magnetic and microwave treated water.

Sci Rep

2023 Mar 16

Elmoslemany AM, Ghamry HI, Awad AA

967. Elucidating the NB-UVB mechanism by comparing transcriptome alteration on the edge and center of psoriatic plaques.

Sci Rep

2023 Mar 16

Boonpethkaew S, Meephansan J, Charoensuksira S

968. Analysis of ecological quality changes and influencing factors in Xiangjiang River Basin.

Sci Rep

2023 Mar 16

Zhang Y, Yi L, Xie B

The Xiangjiang River Basin is an important part of the Yangtze River Basin and an important area in Hunan Province. Thus, taking steps to protect the ecological sustainability of the Xiangjiang River Basin, such as the construction of the protection of ecological security in Hunan Province and the Yangtze River Protection Law, is important for national projects However, research on the ecological quality of the Xiangjiang River Basin is mostly biased toward the evaluation of ecosystem services or an individual ecological index. Furthermore, a long-term evaluation of multiple indicators is lacking. Therefore, based on Google Earth Engine and geographic detectors, the remote sensing ecological index was used to evaluate this area. The year-by-year research on the Xiangjiang River Basin from 2001 to 2020 clarified its past ecological quality change trend, explored the reasons for the ecological quality change, and provided a basis for protecting its ecological quality. The following results are presented. (1) Regarding spatial distribution, areas with poor ecological environments are mainly distributed at the centers of Chang-Zhu-Tan, Hengyang, and various districts and counties. (2) Regarding the time variation, the ecological quality of the Xiangjiang River Basin from 2001 to 2020 showed a slight downward trend, with a downward slope of approximately - 0.0000357143; a rapid increase, with a growth rate of approximately 0.00395; And an overall improvement over 20 years. The areas with declining ecological quality are mainly located in the Chang-Zhu-Tan urban agglomeration, the city center of Hengyang, and the county centers of various county towns. (3) The factor detection results show that human factors play a key role in population density and land use, with average q values of 0.429 and 0.353, respectively. Among natural factors, elevation and slope play a key role, with average q values of 0.230 and 0.351, respectively; hence, Land use directly affect on the ecological quality in a location. These findings will provide important information for managers to formulate ecological restoration measures for the Xiangjiang River.

969. Adapted clustering method for generic analysis of histological fibrosis staining as an open source tool.

Sci Rep

2023 Mar 16

Remes A, Noormalal M, Schmiedel N

970. Heterostrain and temperature-tuned twist between graphene/h-BN bilayers.

Sci Rep

2023 Mar 16

Yang X, Zhang B.

971. On the forecastability of food insecurity.

Sci Rep

2023 Mar 16

Foini P, Tizzoni M, Martini G

972. A microwave scattering spectral method to detect the nanomechanical vibrations embedded in a superconducting qubit.

Sci Rep

2023 Mar 16

Gao HY, Wei LF.

973. Identification of two early blood biomarkers ACHE and CLEC12A for improved risk stratification of critically ill COVID-19 patients.

Sci Rep

2023 Mar 16

Kattner S(#), Müller J(#), Glanz K

974. Unchanged PCNA and DNMT1 dynamics during replication in DNA ligase I-deficient cells but abnormal chromatin levels of non-replicative histone H1.

Sci Rep

2023 Mar 16

Bhandari SK, Wiest N, Sallmyr A

975. Research on SPDTRS-PNN based intelligent assistant diagnosis for breast cancer.

Sci Rep

2023 Mar 16

Kong X, Zhou M, Bian K

976. The propensity to sign-track is associated with externalizing behavior and distinct patterns of reward-related brain activation in youth.

Sci Rep

2023 Mar 16

Colaizzi JM, Flagel SB, Gearhardt AN

977. Assessment of the effect of spacer material on gap and void formation in an endodontic temporary restoration using micro-computed tomography.

Sci Rep

2023 Mar 16

Alkadi M, Algahtani FN, Barakat R

978. Development of Ti-Al-V alloys for usage as single-axis knee prostheses: evaluation of mechanical, corrosion, and tribocorrosion behaviors.

Sci Rep

2023 Mar 16

Pinto BO, Torrento JE, Grandini CR

979. A smart and flexible approach for aggregation of adjacent polygons to meet a minimum target area or attribute value.

Sci Rep

2023 Mar 16

Schiavina M, Melchiorri M, Freire S.

980. Geochemistry and mineralogy of auriferous tailings deposits and their potential for reuse in Nova Lima Region, Brazil.

Sci Rep

2023 Mar 16

Lemos M, Valente T, Reis PM

981. Paleo-biodegradation and hydrocarbon mixing in a major hybrid petroleum reservoir.

Sci Rep

2023 Mar 16

Cesar J, Ardakani OH, Watt E

982. Rotation and transportation of liquid crystal droplets for visualizing electric properties of microstructured electrodes.

Sci Rep

2023 Mar 16

Bono S, Konishi S.

983. Dexmedetomidine improves acute lung injury by activating autophagy in a rat hemorrhagic shock and resuscitation model.

Sci Rep

2023 Mar 16

Lu Y, Shimizu H, Nakamura R

984. Monopolar electrocautery versus sharp dissection in the neck dissection: a retrospective study.

Sci Rep

2023 Mar 16

Obermeier KT(#), Liokatis P(#), Smolka W.

985. Groundwater quality assessment for drinking purposes: a case study in the Mekong Delta, Vietnam.

Sci Rep

2023 Mar 16

Giao NT, Nhien HTH, Anh PK

986. Predicting heart failure onset in the general population using a novel data-mining artificial intelligence method.

Sci Rep

2023 Mar 16

Miyashita Y, Hitsumoto T, Fukuda H

987. Critically synchronized brain waves form an effective, robust and flexible basis for human memory and learning.

Sci Rep

2023 Mar 16

Galinsky VL, Frank LR.

The effectiveness, robustness, and flexibility of memory and learning constitute the very essence of human natural intelligence, cognition, and consciousness. However, currently accepted views on these subjects have, to date, been put forth without any basis on a true physical theory of how the brain communicates internally via its electrical signals. This lack of a solid theoretical framework has implications not only for our understanding of how the brain works, but also for wide range of computational models developed from the standard orthodox view of brain neuronal organization and brain network derived functioning based on the Hodgkin-Huxley ad-hoc circuit analogies that have produced a multitude of Artificial, Recurrent, Convolution, Spiking, etc., Neural Networks (ARCSe NNs) that have in turn led to the standard algorithms that form the basis of artificial intelligence (AI) and machine learning (ML) methods. Our hypothesis, based upon our recently developed physical model of weakly evanescent brain wave propagation (WETCOW) is that, contrary to the current orthodox model that brain neurons just integrate and fire under accompaniment of slow leaking, they can instead perform much more sophisticated tasks of efficient coherent synchronization/desynchronization guided by the collective influence of propagating nonlinear near critical brain waves, the waves that currently assumed to be nothing but inconsequential subthreshold noise. In this paper we highlight the learning and memory capabilities of our WETCOW framework and then apply it to the specific application of AI/ML and Neural Networks. We demonstrate that the learning inspired by these critically synchronized brain waves is shallow, yet its timing and accuracy outperforms deep ARCSe counterparts on standard test datasets. These results have implications for both our understanding of brain function and for the wide range of AI/ML applications.

988. Ingestion and excretion dynamics of microplastics by black soldier fly larvae and correlation with mouth opening size.

Sci Rep

2023 Mar 16

Lievens S, Vervoort E, Bruno D

989. The clinical influence of nasal surgery on PAP compliance and optimal application among OSA subjects uncomfortable with PAP device wear.

Sci Rep

2023 Mar 16

Cha H, Oh H, Han SA

990. A retrospective study on comparison of clinical characteristics and outcomes of diabetic ketoacidosis patients with and without acute pancreatitis.

Sci Rep

2023 Mar 16

Khan AA, Ata F, Yousaf Z

The co-existence of diabetic ketoacidosis (DKA) with acute pancreatitis (AP) is associated with unfavorable clinical outcomes. However, diagnosing AP in DKA patients is challenging and often missed due to overlapping symptoms. The aim of this retrospective observational study was to compare the clinical characteristics and outcomes of patients with concomitant DKA and AP or DKA alone. Data of patients with DKA admitted between January 2015 to August 2021 to four hospitals in Qatar was extracted from the electronic health record (Cerner). American Diabetes Association criteria and Atlanta criteria were used for DKA and AP diagnosis, respectively. Independent T-test or Mann-Whitney U test was used to analyze continuous variables, whereas categorical variables were analyzed via Chi-square or Fischer exact tests as appropriate. Univariate and multivariate logistic regression models were generated to assess the correlations. A p-value of < 0.05 was considered statistically significant. Of 936 patients with DKA, 84 (9.0%) had coexisting AP. AP was most common in the Asian race (66%, p < 0.001). Patients with DKA and AP were older, had higher admission anion-gap, white cell count, hemoglobin (hb), neutrophil/lymphocyte ratio, urea, creatinine, maximum blood glucose during the episode, total cholesterol and triglyceride level (TGL) (p < 0.05). They had a lower admission venous pH and bicarbonate at 6 h. Patients in the DKA with AP group also had a longer length of stay (LOS), DKA duration and a higher rate of ICU admission (p-values ≤ 0.001). In-hospital mortality, 3-month all-cause readmission, 6-month and 12-month DKA recurrence did not differ between the two groups. Univariate logistic regression analysis showed age, Asian ethnicity, male gender, T2D, admission WBC count, hb, urea, creatinine, potassium, venous pH, bicarbonate, anion gap, total cholesterol, TGL and LDL level were significantly associated with the development of DKA with AP (p < 0.05). In multivariate logistic regression analysis, age and total cholesterol level were associated with concomitant DKA and AP (p < 0.05). Patients with concomitant DKA and AP have more severe derangement in markers of DKA severity, inflammation, kidney injury and metabolic profile, along with a longer DKA duration, LOS and requirement for ICU support compared to DKA patients without AP. This highlights the clinical significance of diagnosing the co-existence of DKA with AP, as the combination results in significantly worse clinical outcomes and greater healthcare utilization than in patients with only DKA.

991. Probiotic disruption of quorum sensing reduces virulence and increases cefoxitin sensitivity in methicillin-resistant Staphylococcus aureus.

Sci Rep

2023 Mar 16

Cella MA, Coulson T, MacEachern S

992. Non-alcoholic fatty liver disease is associated with decreased bone mineral density in upper Egyptian patients.

Sci Rep

2023 Mar 16

Hassan AM, Haridy MA, Shoaeir MZ

993. Ecological drivers of breeding periodicity in four forest neotropical eagles.

Sci Rep

2023 Mar 16

Blank MH, Guimarães PR Jr, do Nascimento LF

994. Effects of virtual reality-based intervention on depression in stroke patients: a meta-analysis.

Sci Rep

2023 Mar 16

Liu H(#), Cheng Z(#), Wang S

995. Establishing an RNA fusions panel in soft tissue sarcoma with clinical validation.

Sci Rep

2023 Mar 16

Huang X, Li G, Li L

996. Identification of potential LncRNAs as papillary thyroid carcinoma biomarkers based on integrated bioinformatics analysis using TCGA and RNA sequencing data.

Sci Rep

2023 Mar 16

Feng JL(#), Zheng WJ(#), Xu L

997. A network analysis on biopsychosocial factors and pain-related outcomes assessed during a COVID-19 lockdown.

Sci Rep

2023 Mar 16

Gevers-Montoro C, Liew BXW, Deldar Z

998. Early DNase-I therapy delays secondary brain damage after traumatic brain injury in adult mice.

Sci Rep

2023 Mar 16

Krämer TJ, Pickart F, Pöttker B

999. A urine-based ELISA with recombinant non-glycosylated SARS-CoV-2 spike protein for detecting anti-SARS-CoV-2 spike antibodies.

Sci Rep

2023 Mar 16

Ramos FF, Bagno FF, Vassallo PF

1000. The effects of visual working memory load on detection and neural processing of task-unrelated auditory stimuli.

Sci Rep

2023 Mar 16

Brockhoff L(#), Vetter L(#), Bruchmann M

1001. Evaluation of the main regulators of systemic iron homeostasis in pyruvate kinase deficiency.

Sci Rep

2023 Mar 16

Zaninoni A(#), Marra R(#), Fermo E

1002. Platelet to lymphocyte ratio is a risk factor for failure of non-operative treatment of colonic diverticulitis.

Sci Rep

2023 Mar 16

Kim JH, Han SH, Lee JW

1003. Effects of light and noise pollution on avian communities of European cities are correlated with the species' diet.

Sci Rep

2023 Mar 16

Morelli F, Tryjanowski P, Ibáñez-Álamo JD

1004. Whole genome characterization and diagnostics of prunus necrotic ringspot virus (PNRSV) infecting apricot in India.

Sci Rep

2023 Mar 16

Noorani MS, Baig MS, Khan JA

1005. AI co-pilot: content-based image retrieval for the reading of rare diseases in chest CT.

Sci Rep

2023 Mar 16

Haubold J, Zeng K, Farhand S

1006. A validated protocol for eDNA-based monitoring of within-species genetic diversity in a pond-breeding amphibian.

Sci Rep

2023 Mar 16

Zanovello L, Girardi M, Marchesini A

1007. Characterization of pancreatic cancer with ultra-low tumor mutational burden.

Sci Rep

2023 Mar 16

Imamura T, Ashida R, Ohshima K

1008. Intergenerational impact of dietary protein restriction in dairy ewes on epigenetic marks in the perirenal fat of their suckling lambs.

Sci Rep

2023 Mar 16

Fonseca PAS, Suárez-Vega A, Pelayo R

1009. A simplified model to estimate nonlinear turbulent transport by linear dynamics in plasma turbulence.

Sci Rep

2023 Mar 16

Nakayama T, Nakata M, Honda M

1010. Synthesis and structure-activity relationship studies of benzimidazole-thioquinoline derivatives as α-glucosidase inhibitors.

Sci Rep

2023 Mar 16

Moghadam Farid S, Noori M, Nazari Montazer M

1011. Artificial intelligence-based optimization for chitosan nanoparticles biosynthesis, characterization and in‑vitro assessment of its anti-biofilm potentiality.

Sci Rep

2023 Mar 16

El-Naggar NE, Dalal SR, Zweil AM

Chitosan nanoparticles (CNPs) are promising biopolymeric nanoparticles with excellent physicochemical, antimicrobial, and biological properties. CNPs have a wide range of applications due to their unique characteristics, including plant growth promotion and protection, drug delivery, antimicrobials, and encapsulation. The current study describes an alternative, biologically-based strategy for CNPs biosynthesis using Olea europaea leaves extract. Face centered central composite design (FCCCD), with 50 experiments was used for optimization of CNPs biosynthesis. The artificial neural network (ANN) was employed for analyzing, validating, and predicting CNPs biosynthesis using Olea europaea leaves extract. Using the desirability function, the optimum conditions for maximum CNPs biosynthesis were determined theoretically and verified experimentally. The highest experimental yield of CNPs (21.15 mg CNPs/mL) was obtained using chitosan solution of 1%, leaves extract solution of 100%, initial pH 4.47, and incubation time of 60 min at 53.83°C. The SEM and TEM images revealed that CNPs had a spherical form and varied in size between 6.91 and 11.14 nm. X-ray diffraction demonstrates the crystalline nature of CNPs. The surface of the CNPs is positively charged, having a Zeta potential of 33.1 mV. FTIR analysis revealed various functional groups including C-H, C-O, CONH2, NH2, C-OH and C-O-C. The thermogravimetric investigation indicated that CNPs are thermally stable. The CNPs were able to suppress biofilm formation by P. aeruginosa, S. aureus and C. albicans at concentrations ranging from 10 to 1500 µg/mL in a dose-dependent manner. Inhibition of biofilm formation was associated with suppression of metabolic activity, protein/exopolysaccharide moieties, and hydrophobicity of biofilm encased cells (r ˃ 0.9, P = 0.00). Due to their small size, in the range of 6.91 to 11.14 nm, CNPs produced using Olea europaea leaves extract are promising for applications in the medical and pharmaceutical industries, in addition to their potential application in controlling multidrug-resistant microorganisms, especially those associated with post COVID-19 pneumonia in immunosuppressed patients.

1012. Ecological niche overlap in the Arctic vegetation influenced by seabirds.

Sci Rep

2023 Mar 16

Zwolicki A, Zmudczyńska-Skarbek K, Weydmann-Zwolicka A

1013. Impact of hypothermia alert device (BEMPU) on improvement of duration of Kangaroo Mother Care (KMC) provided at home: parallel-group randomized control trial.

Sci Rep

2023 Mar 16

Nimbalkar SM, Patel VT, Patel DV

The objective of the study was to determine if using the hypothermia-detecting bracelet (named BEMPU) improves the duration of Kangaroo Mother Care (KMC) at home by one hour. This parallel-group randomized controlled trial was conducted at a step-down nursery of a teaching hospital. Neonates between 1000 and 2000 g were randomized to BEMPU and control groups at the time of discharge. BEMPU was applied at the wrist of each newborn in the BEMPU (intervention) group. Parents were advised to keep the BEMPU in place till 4 weeks post-discharge. The BEMPU generates a beep sound as an alarm when a newborn's temperature drops below 36.5 °C. Parents in both groups were trained to provide KMC at home. Parents in the BEMPU group received the "KMC chart" and "BEMPU beep chart," while the control group received the "KMC chart" only. In the "KMC chart," parents entered information about KMC hours on a real-time basis, and in the "BEMPU beep chart," they entered information about alarm beeps from BEMPU on a real-time basis till 4 weeks post-discharge. Independent samples t-test was used to compare mean KMC hours between the two groups. A total of 128 neonates participated in the study (64 in BEMPU and 64 in Control groups). The mean(SD) gestational age for the BEMPU group was 34.04(2.84) weeks vs 34.75(2.70) weeks for the control group. In BEMPU group, mean(SD) daily time spent doing KMC was significantly higher in 1st week [4.78(2.93) vs. 3.22(2.44) h, p = 0.003], in 2nd week [4.52(3.43) vs. 2.84(2.95) h, p = 0.008], in 3rd week [4.23(3.71) vs. 2.30(2.70) h, p = 0.003], in 4th week [3.72(3.30) vs. 1.95(2.65) h, p = 0.003] as compared to control group. BEMPU improved the daily duration of KMC hours at home compared to the control group over four weeks. Clinical Trial Registration: This trial is registered at Clinical Trials Registry India with registration number: CTRI/2018/08/015154 and accessible at http://ctri.nic.in/Clinicaltrials/pdf_generate.php?trialid=27600&EncHid=&modid=&compid=%27,%2727600det%27 Registered on 01/08/2018.

1014. Physiological specialization of Puccinia triticina and genome-wide association mapping provide insights into the genetics of wheat leaf rust resistance in Iran.

Sci Rep

2023 Mar 16

Talebi R, Mahboubi M, Naji AM

1015. Gut microbiome signatures of Yorkshire Terrier enteropathy during disease and remission.

Sci Rep

2023 Mar 16

Doulidis PG, Galler AI, Hausmann B

1016. In silico analysis to identify miR-1271-5p/PLCB4 (phospholipase C Beta 4) axis mediated oxaliplatin resistance in metastatic colorectal cancer.

Sci Rep

2023 Mar 16

Lee CC, Lee AW, Wei PL

Oxaliplatin (OXA) is the first-line chemotherapy drug for metastatic colorectal cancer (mCRC), and the emergence of drug resistance is a major clinical challenge. Although there have been numerous studies on OXA resistance, but its underlying molecular mechanisms are still unclear. This study aims to identify key regulatory genes and pathways associated with OXA resistance. The Gene Expression Omnibus (GEO) GSE42387 dataset containing gene expression profiles of parental and OXA-resistant LoVo cells was applied to explore potential targets. GEO2R, STRING, CytoNCA (a plug-in of Cytoscape), and DAVID were used to analyze differentially expressed genes (DEGs), protein-protein interactions (PPIs), hub genes in PPIs, and gene ontology (GO)/Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analysis. R2 online platform was used to run a survival analysis of validated hub genes enriched in KEGG pathways. The ENCORI database predicted microRNAs for candidate genes. A survival analysis of those genes was performed, and validated using the OncoLnc database. In addition, the 'clusterProfiler' package in R was used to perform gene set enrichment analysis (GSEA). We identified 395 DEGs, among which 155 were upregulated and 240 were downregulated. In total, 95 DEGs were screened as hub genes after constructing the PPI networks. Twelve GO terms and three KEGG pathways (steroid hormone biosynthesis, malaria, and pathways in cancer) were identified as being significant in the enrichment analysis of hub genes. Twenty-one hub genes enriched in KEGG pathways were defined as key genes. Among them AKT3, phospholipase C Beta 4 (PLCB4), and TGFB1 were identified as OXA-resistance genes through the survival analysis. High expressions of AKT3 and TGFB1 were each associated with a poor prognosis, and lower expression of PLCB4 was correlated with worse survival. Further, high levels of hsa-miR-1271-5p, which potentially targets PLCB4, were associated with poor overall survival in patients with CRC. Finally, we found that PLCB4 low expression was associated with MAPK signaling pathway and VEGF signaling pathway in CRC. Our results demonstrated that hsa-miR-1271-5p/PLCB4 in the pathway in cancer could be a new potential therapeutic target for mCRC with OXA resistance.

1017. Dyadic inter-brain EEG coherence induced by interoceptive hyperscanning.

Sci Rep

2023 Mar 16

Balconi M, Angioletti L.

1018. Short term results in a population based study indicate advantage for laparoscopic colon cancer surgery versus open.

Sci Rep

2023 Mar 16

Petersson J, Matthiessen P, Jadid KD

1019. Production of neutralizing antibody fragment variants in the cytoplasm of E. coli for rapid screening: SARS-CoV-2 a case study.

Sci Rep

2023 Mar 16

Tungekar AA, Recacha R, Ruddock LW.

1020. Anomaly detection using spatial and temporal information in multivariate time series.

Sci Rep

2023 Mar 16

Tian Z, Zhuo M, Liu L

1021. Airborne dimethyl sulfide (DMS) cues dimethylsulfoniopropionate (DMSP) increases in the intertidal green alga Ulva fenestrata.

Sci Rep

2023 Mar 15

Van Alstyne KL, Butler JK, Smith N.

1022. Overexpression of Physcomitrium patens cell cycle regulators leads to larger gametophytes.

Sci Rep

2023 Mar 15

Peramuna A, López CQ, Rios FJA

Sci Rep

2023 Mar 15

Li Z, Zhao J, Huang X

Bladder cancer (BC) is a representative malignant tumor type, and the significance of N7-methyguanosine (m7G)-related lncRNAs in BC is still unclear. Utilizing m7G-related lncRNAs, we developed a prognostic model to evaluate BC's prognosis and tumor immunity. First, we selected prognostic lncRNAs related to m7G by co-expression analysis and univariate Cox regression and identified two clusters by consensus clustering. The two clusters differed significantly in terms of overall survival, clinicopathological factors, and immune microenvironment. Then, we further constructed a linear stepwise regression signature by multivariate Cox and least absolute shrinkage and selection operator (LASSO) regression analysis. Patients fell into high-risk (HR) and low-risk (LR) groups considering the train group risk score. HR group had worse prognoses when stratified by clinicopathological factors. The receiver operating curve (ROC) suggested that the signature had a better prognostic value. Tumor mutation burden (TMB) showed a negative relevance to the risk score, and patients with low TMB presented a better prognosis. Validation of the signature was carried out with multivariate and univariate Cox regression analysis, nomogram, principal component analysis (PCA), C-Index, and quantitative reverse transcriptase PCR (qRT-PCR). Finally, the gene set enrichment analysis (GSEA) demonstrated the enrichment of tumor-related pathways in HR groups, and single-sample gene set enrichment analysis (ssGSEA) indicated a close association of risk score with tumor immunity. According to the drug sensitivity test, the signature could predict the effects of conventional chemotherapy drugs. In conclusion, our study indicates the close relevance of m7G-related lncRNAs to BC, and the established risk signature can effectively evaluate patient prognosis and tumor immunity and is expected to become a novel prognostic marker for BC patients.

1024. Longitudinal telomere dynamics within natural lifespans of a wild bird.

Sci Rep

2023 Mar 15

Pepke ML, Kvalnes T, Wright J

1025. Spermidine dietary supplementation and polyamines level in reference to survival and lifespan of honey bees.

Sci Rep

2023 Mar 15

Đorđievski S, Vukašinović EL, Čelić TV

1026. Novel hybrid evolutionary algorithm for bi-objective optimization problems.

Sci Rep

2023 Mar 15

Dib O.

1027. Dissolution behavior of radiocesium-bearing microparticles as a function of solution compositions.

Sci Rep

2023 Mar 15

Okumura T, Yamaguchi N, Kogure T.

1028. Polycystic kidney disease 2-like 1 channel contributes to the bitter aftertaste perception of quinine.

Sci Rep

2023 Mar 15

Shimizu T, Fujii T, Hanita K

1029. Biphasic oxygen tension promotes the formation of transferable blastocysts in patients without euploid embryos in previous monophasic oxygen cycles.

Sci Rep

2023 Mar 15

Chen HH(#), Lee CI(#), Huang CC

1030. Post-fumigation sub-lethal activities of phosphine and ethyl formate on survivorship, fertility and female sex pheromone production of Callosobruchus chinensis (L.).

Sci Rep

2023 Mar 15

Chiluwal K, Lee BH, Kwon TH

1031. The impact of contextual information on aesthetic engagement of artworks.

Sci Rep

2023 Mar 15

Darda KM, Chatterjee A.

1032. Artificial intelligence evaluation of COVID-19 restrictions and speech therapy effects on the autistic children's behavior.

Sci Rep

2023 Mar 15

Sabzevari F, Amelirad O, Moradi Z

1033. Comprehensive characterization of B7 family members in NSCLC and identification of its regulatory network.

Sci Rep

2023 Mar 15

Xiao M(#), Pang C(#), Xiang S

1034. Extremely small wasps independently lost the nuclei in the brain neurons of at least two lineages.

Sci Rep

2023 Mar 15

Polilov AA, Hakimi KD, Makarova AA.

1035. The effect of 1,2-dioleoyl-3-trimethylammonium propane (DOTAP) Addition on the physical characteristics of β-ionone liposomes.

Sci Rep

2023 Mar 15

Miatmoko A, Asmoro FH, Azhari AA

1036. The mediating effects of personality traits on the relationship of youth conduct problems and mood disorders with adulthood suicidality.

Sci Rep

2023 Mar 15

Wang TY, Chen HC, Hsu CD

1037. Impact of catheter ablation and subsequent recurrence of atrial fibrillation on glucose status in patients undergoing continuous glucose monitoring.

Sci Rep

2023 Mar 15

Baba M, Yoshida K, Nogami A

1038. Characterization and utility of two monoclonal antibodies to cholera toxin B subunit.

Sci Rep

2023 Mar 15

Verjan Garcia N, Santisteban Celis IC, Dent M

1039. Access to inclusive sanitation and participation in sanitation programs for people with disabilities in Indonesia.

Sci Rep

2023 Mar 15

Daniel D, Nastiti A, Surbakti HY

1040. Relationship between electrically evoked compound action potential thresholds and behavioral T-levels in implanted children with cochlear nerve deficiency.

Sci Rep

2023 Mar 15

Chao X, Wang R, Luo J

1041. Hand hygiene practice and associated factors among rural communities in northwest Ethiopia.

Sci Rep

2023 Mar 15

Gizaw Z, Demissie NG, Gebrehiwot M

1042. High interspecific competitiveness of the invasive plant Xanthium italicum Moretti severely reduces the yield and quality of Carthamus tinctorius L.

Sci Rep

2023 Mar 15

Ma X, Hou M, Ma M.

1043. Inoculation with black soldier fly larvae alters the microbiome and volatile organic compound profile of decomposing food waste.

Sci Rep

2023 Mar 15

Michishita R, Shimoda M, Furukawa S

1044. Comprehensive prognostic effects of systemic inflammation and Insulin resistance in women with breast cancer with different BMI: a prospective multicenter cohort.

Sci Rep

2023 Mar 15

Ruan GT(#), Xie HL(#), Hu CL(#)

1045. srdA mutations suppress the rseA/cpsA deletion mutant conidiation defect in Aspergillus nidulans.

Sci Rep

2023 Mar 15

Ogawa M, Fukuda R, Iwama R

1046. Understanding the microstructure of a core-shell anode catalyst layer for polymer electrolyte water electrolysis.

Sci Rep

2023 Mar 15

De Angelis S, Schuler T, Sabharwal M

1047. αSiC - βSiC - graphene composites.

Sci Rep

2023 Mar 15

Razmjoo A, Baharvandi HR, Ehsani N.

In this study, the mechanical properties of the pressureless sintered samples of α-SiC based composite containing 0-3 wt.% graphene and 0-15 wt.% nano β-SiC were investigated. Simultaneous usage of nano β-SiC and graphene and transformation of β-SiC (3C) to α-SiC (6H/4H) resulted in elongation of secondary α-SiC grains, which significantly improved the mechanical properties (e.g. fracture toughness) of SiC ceramics. According to the results, the highest Relative density of 99.04%, Young's modulus of 537.76 GPa and fracture toughness of 5.73 MPa × m1/2 were obtained in the sample containing 5 wt.% nano β-SiC and 1 wt.% graphene (5B1G). In addition, two methods of measuring bending strength including three-point bending tests and biaxial tests (piston-on-three-ball) were compared. Strip-shaped specimens were prepared for three-point bending test and disc-shaped specimens were prepared for biaxial bending test. Each bending test was evaluated using a universal testing machine. The results showed that the biaxial bending strength is less than the three-point bending strength. Also, the maximum three-point bending strength of 582.01 MPa and biaxial bending of 441.56 MPa were obtained in 5 wt.% Nano β-SiC and 1 wt.% Graphene samples (5B1G). Studies have shown that in addition to the many advantages of using the biaxial bending method, the results have a very similar trend to the three-point bending strength. Also, the most-increased hardnesses of 28.03 GPa and 29.97 GPa were seen in the sample containing 5 wt.% nano β-SiC (5B) with forces of 10 N and 1 N, respectively. One of the effective mechanisms in improving the fracture toughness of α-SiC ceramics is crack deflection/bridging. Also, the difference in thermal expansion of the α-SiC matrix and the reinforcements, leading to the creation of residual stresses between the matrix grains and the reinforcement, is effective in improving the mechanical properties (e.g. strength and fracture toughness).

1048. IntelliSleepScorer, a software package with a graphic user interface for automated sleep stage scoring in mice based on a light gradient boosting machine algorithm.

Sci Rep

2023 Mar 15

Wang LA, Kern R, Yu E

Machine learning has been applied in recent years to categorize sleep stages (NREM, REM, and wake) using electroencephalogram (EEG) recordings; however, a well-validated sleep scoring automatic pipeline in rodent research is still not publicly available. Here, we present IntelliSleepScorer, a software package with a graphic user interface to score sleep stages automatically in mice. IntelliSleepScorer uses the light gradient boosting machine (LightGBM) to score sleep stages for each epoch of recordings. We developed LightGBM models using a large cohort of data, which consisted of 5776 h of sleep EEG and electromyogram (EMG) signals across 519 unique recordings from 124 mice. The LightGBM model achieved an overall accuracy of 95.2% and a Cohen's kappa of 0.91, which outperforms the baseline models such as the logistic regression model (accuracy = 93.3%, kappa = 0.88) and the random forest model (accuracy = 94.3%, kappa = 0.89). The overall performance of the LightGBM model as well as the performance across different sleep stages are on par with that of the human experts. Most importantly, we validated the generalizability of the LightGBM models: (1) The LightGBM model performed well on two publicly available, independent datasets (kappa > = 0.80), which have different sampling frequency and epoch lengths; (2) The LightGBM model performed well on data recorded at a lower sampling frequency (kappa = 0.90); (3) The performance of the LightGBM model is not affected by the light/dark cycle; and (4) A modified LightGBM model performed well on data containing only one EEG and one EMG electrode (kappa > = 0.89). Taken together, the LightGBM models offer state-of-the-art performance for automatic sleep stage scoring in mice. Last, we implemented the IntelliSleepScorer software package based on the validated model to provide an out-of-box solution to sleep researchers (available for download at https://sites.broadinstitute.org/pan-lab/resources ).

1049. An automatic entropy method to efficiently mask histology whole-slide images.

Sci Rep

2023 Mar 15

Song Y, Cisternino F, Mekke JM

1050. Label-free multiphoton microscopy enables histopathological assessment of colorectal liver metastases and supports automated classification of neoplastic tissue.

Sci Rep

2023 Mar 15

Galli R, Siciliano T, Aust D

1051. Angiotensin II type 2 receptor activation preserves megalin in the kidney and prevents proteinuria in high salt diet fed rats.

Sci Rep

2023 Mar 15

Kulkarni K, Patel S, Ali R

1052. Real-time botnet detection on large network bandwidths using machine learning.

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2023 Mar 15

Velasco-Mata J, González-Castro V, Fidalgo E

1053. Irreversibility analysis of electromagnetic hybrid nanofluid for Cattaneo-Christov heat flux model using finite element approach.

Sci Rep

2023 Mar 15

Qureshi MA.

1054. Temperature-controlled porcine eye holder for observing intraocular temperature during cataract surgery.

Sci Rep

2023 Mar 15

Minami K, Yaguchi S, Bissen-Miyajima H.

1055. A novel natural scaffold layer improving efficiency, stability and reproducibility of Perovskite solar cells.

Sci Rep

2023 Mar 15

Yenel E, Kus M.

1056. Face masks are less effective than sunglasses in masking face identity.

Sci Rep

2023 Mar 15

Or CC, Ng KYJ, Chia Y

1057. The relationship between minor coronal asymmetry of the spine and measures of spinal sagittal shape in adolescents without visible scoliosis.

Sci Rep

2023 Mar 15

Gardner A, Berryman F, Pynsent P.

1058. Coenzyme Q(10) supplementation improves the motor function of middle-aged mice by restoring the neuronal activity of the motor cortex.

Sci Rep

2023 Mar 15

Inoue R, Miura M, Yanai S

1059. Isotherm and kinetic studies of acid yellow 11 dye adsorption from wastewater using Pisum Sativum peels microporous activated carbon.

Sci Rep

2023 Mar 15

El-Nemr MA, Yılmaz M, Ragab S

In this study, Pea Peels-Activated Carbon (PPAC), a novel biochar, was created from leftover pea peels (Pisum sativum) by wet impregnation with ZnCl2 and subsequent heating to 600, 700, and 800 °C in a CO2 atmosphere. Investigated how the newly acquired biochar affected the capacity to extract the AY11 dye from the aqueous solution. Through the use of FTIR, XRD, SEM, BJH, BET, DSC, EDX, and TGA studies, the prepared PPAC was identified. It was found that a pH of 2 is optimum for the AY11 dye elimination. The highest removal percentage of AY11 dye was 99.10% using a beginning AY11 dye concentration of 100 mg/L and a 1.0 g/L dose of PPAC. The highest adsorption capacity (Qm) of the PPAC was 515.46 mg/g. Freundlich (FIM), Halsey (HIM), Langmuir (LIM), Tempkin (TIM), and Gineralize (GIM) isotherm models were useful in examining the adsorption results. A variety of error functions, including the average percent errors (APE), root mean square errors (RMS), Marquardt's percent standard deviation (MPSD), hybrid error function (HYBRID), Chi-square error (X2) and a sum of absolute errors (EABS) equations, were also applied to test the isotherm models data. The PPAC experimental data were best suited by the HIM and FIM isotherm models. Elovich (EM), Pseudo-first-order (PFOM), Intraparticle diffusion (IPDM), Pseudo-second-order (PSOM), and Film diffusion (FDM) models were applied to study the kinetic adsorption results. The PSOM had a strong correlation coefficient (R2 > 0.99), and it was principally responsible for controlling the adsorption rate. Anions are typically absorbed during the adsorption mechanism of AY11 dye by PPAC owing to attractive electrostatic forces created with an increase in positively charged areas at acidic pH levels. The regenerated PPAC was used in six successive adsorption/desorption cycles. This study's outcomes show that PPAC successfully removes the AY11 dye from the aqueous solution; as a result, PPAC can be used repeatedly without experiencing considerable loss in effectiveness.

1060. Time-dependent impact of co-matured manure with elemental sulfur and biochar on the soil agro-ecological properties and plant biomass.

Sci Rep

2023 Mar 15

Holatko J, Hammerschmiedt T, Mustafa A

1061. Mitochondrion-targeted antioxidant SkQ1 prevents rapid animal death caused by highly diverse shocks.

Sci Rep

2023 Mar 15

Skulachev VP, Vyssokikh MY, Chernyak BV

1062. Effect of redroot pigweed interference on antioxidant enzyme and light response of common bean (Phaseolus vulgaris L.) depends on cultivars and growth stages.

Sci Rep

2023 Mar 15

Tabatabaiepour SZ, Tahmasebi Z, Taab A

1063. Enhancing reading accuracy through visual search training using symbols.

Sci Rep

2023 Mar 15

Vialatte A, Aguera PE, Bedoin N

1064. Polyamine-mediated mechanisms contribute to oxidative stress tolerance in Pseudomonas syringae.

Sci Rep

2023 Mar 15

Solmi L, Rossi FR, Romero FM

1065. Mycophenolic acid directly protects podocytes by preserving the actin cytoskeleton and increasing cell survival.

Sci Rep

2023 Mar 15

Abo Zed SED(#), Hackl A(#), Bohl K

1066. Utilization possibilities of steel slag as backfill material in coastal structures.

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2023 Mar 15

Tozsin G, Yonar F, Yucel O

1067. Rethinking infrastructure design: evaluating pedestrians and VRUs' psychophysiological and behavioral responses to different roadway designs.

Sci Rep

2023 Mar 15

Guo X, Angulo A, Tavakoli A

1068. Effects of plyometric vs. strength training on strength, sprint, and functional performance in soccer players: a randomized controlled trial.

Sci Rep

2023 Mar 14

Hasan S.

1069. Spatial and temporal distribution characteristics of antibiotics and heavy metals in the Yitong River basin and ecological risk assessment.

Sci Rep

2023 Mar 14

Zhao K, Wang Q, Qian S

1070. TiO(2)-Ag-NP adhesive photocatalytic films able to disinfect living indoor spaces with a straightforward approach.

Sci Rep

2023 Mar 14

Chirumbolo S, Gibellini D, Berto L

1071. Use of dual genomic sequencing to screen mitochondrial diseases in pediatrics: a retrospective analysis.

Sci Rep

2023 Mar 14

Wu TH, Peng J, Yang L

1072. Climate-driven habitat shifts of high-ranked prey species structure Late Upper Paleolithic hunting.

Sci Rep

2023 Mar 14

Yaworsky PM, Hussain ST, Riede F.

1073. Significance of Dufour and Soret aspects on dynamics of water based ternary hybrid nanofluid flow in a 3D computational domain.

Sci Rep

2023 Mar 14

Bilal S, Asjad MI, Haq SU

1074. Testing multiple hypotheses on the colour change of treefrogs in response to various external conditions.

Sci Rep

2023 Mar 14

Park C, No S, Yoo S

Amphibians are famous for their ability to change colours. And a considerable number of studies have investigated the internal and external factors that affect the expression of this phenotypic plasticity. Evidence to date suggests that thermoregulation and camouflage are the main pressures that influence frogs' adaptive colour change responses. However, certain gaps in our knowledge of this phenomenon remain, namely: (i) how do frogs adjust their colour in response to continuously changing external conditions?; (ii) what is the direction of change when two different functions of colour (camouflage and thermoregulation) are in conflict?; (iii) does reflectance in the near-infrared region show thermally adaptive change?; and (iv) is the colour change ability of each frog an individual trait (i.e., consistent within an individual over time)? Using Dryophytes japonicus (Hylidae, Hyla), we performed a series of experiments to answer the above questions. We first showed that frogs' responses to continuously-changing external conditions (i.e., background colour and temperature) were not linear and limited to the range they experience under natural conditions. Second, when a functional conflict existed, camouflage constrained the adaptive response for thermoregulation and vice versa. Third, though both temperature and background colour induced a change in near-infrared reflectance, this change was largely explained by the high correlation between colour (reflectance in the visible spectrum) and near-infrared reflectance. Fourth, within-individual variation in colour change capacity (i.e., the degree of colour change an individual can display) was lower than inter-individual variation, suggesting individuality of colour change capacity; however, we also found that colour change capacity could change gradually with time within individuals. Our results collectively reveal several new aspects of how evolution shapes the colour change process and highlight how variation in external conditions restricts the extent of colour change in treefrogs.

1075. Secular trends in physical fitness of rural Chinese children and adolescents aged 7-18 years from 1985 to 2019.

Sci Rep

2023 Mar 14

Li C, Taerken AY, Li Q

1076. Association between the early mobilization of mechanically ventilated patients and independence in activities of daily living at hospital discharge.

Sci Rep

2023 Mar 14

Watanabe S, Hirasawa J, Naito Y

Physical dysfunction after discharge from the intensive care unit (ICU) is recognized as a common complication among ICU patients. Early mobilization (EM), defined as the ability to sit on the edge of the bed within 5 days, may help improve physical dysfunction. However, the barriers to, and achievement of, EM and their impact on physical dysfunction have not been fully investigated. This study aimed to investigate the achievement of EM and barriers to it and their impact on patient outcomes in mechanically ventilated ICU patients. We conducted this multicenter retrospective cohort study by collecting data from six ICUs in Japan. Consecutive patients who were admitted to the ICU between April 2019 and March 2020, were aged ≥ 18 years, and received mechanical ventilation for > 48 h were eligible. The primary outcome was the rate of independent activities of daily living (ADL), defined as a score ≥ 70 on the Barthel index at hospital discharge. Daily changes in barriers of mobilization, including consciousness, respiratory, circulatory, medical staff factors, and device factors (catheter, drain, and dialysis), along with the clinical outcomes were investigated. The association among barriers, mobilization, and Barthel index ≥ 70 was analyzed using multivariable logistic regression analysis. During the study period, 206 patients were enrolled. EM was achieved in 116 patients (68%) on the fifth ICU day. The primary outcome revealed that achieving EM was associated with a Barthel index ≥ 70 at hospital discharge [adjusted odds ratio (AOR), 3.44; 95% confidence interval (CI), 1.70-6.96]. Device factors (AOR, 0.31; 95% CI, 0.13-0.75, respectively) were significantly associated with EM achievement. EM was associated with independent ADL at hospital discharge. Time to first mobilization and barriers to achieving mobilization can be important parameters for achieving ADL independence at discharge. Further research is required to determine the most common barriers so that they can be identified and removed.

1077. Erbium-doped (Pb(0.9)-Er(0.01)-Zr(0.09)) and (Pb(0.9)-Er(0.01)-Zr(0.045)-Ti(0.045)) nano-crystalline films and nano-rods ceramic synthesis by sol-gel technique for energy-storage application.

Sci Rep

2023 Mar 14

Ibrahim FA, El-Desoky MM.

1078. Mosquito swarm counting via attention-based multi-scale convolutional neural network.

Sci Rep

2023 Mar 14

Chen H, Ren J, Sun W

1079. Wavelet-artificial neural network to predict the acetone sensing by indium oxide/iron oxide nanocomposites.

Sci Rep

2023 Mar 14

Iranmanesh R, Pourahmad A, Shabestani DS

1080. Antiretroviral therapy regimen modification rates and associated factors in a cohort of HIV/AIDS patients in Asmara, Eritrea: a 16-year retrospective analysis.

Sci Rep

2023 Mar 14

Mengistu ST, Yohannes A, Issaias H

Combined antiretroviral therapy (cART) durability and time to modification are important quality indicators in HIV/AIDs treatment programs. This analysis describes the incidence, patterns, and factors associated with cART modifications in HIV patients enrolled in four treatment centers in Asmara, Eritrea from 2005 to 2021. Retrospective cohort study combining data from 5020 [males, 1943 (38.7%) vs. females, 3077 (61.3%)] patients were utilized. Data on multiple demographic and clinical variables were abstracted from patient's charts and cART program registry. Independent predictors of modification and time to specified events were evaluated using a multi-variable Cox-proportional hazards model and Kaplan-Meier analysis. The median (±IQR) age, CD4+ T-cell count, and proportion of patients with WHO Clinical stage III/IV were 48 (IQR 41-55) years; 160 (IQR 80-271) cells/µL; and 2667 (53.25%), respectively. The cumulative frequency of all cause cART modification was 3223 (64%): 2956 (58.8%) substitutions; 37 (0.7%) switches; and both, 230 (4.5%). Following 241,194 person-months (PMFU) of follow-up, incidence rate of cART substitution and switch were 12.3 (95% CI 11.9-12.8) per 1000 PMFU and 3.9 (95% CI 3.2-4.8) per 10,000 PMFU, respectively. Prominent reasons for cART substitution included toxicity/intolerance, drug-shortage, new drug availability, treatment failure, tuberculosis and pregnancy. The most common adverse event (AEs) associated with cART modification included lipodystrophy, anemia and peripheral neuropathy, among others. In the adjusted multivariate Cox regression model, Organisation (Hospital B: aHR = 1.293, 95% CI 1.162-1.439, p value < 0.001) (Hospital D: aHR = 1.799, 95% CI 1.571-2.060, p value < 0.001); Initial WHO clinical stage (Stage III: aHR = 1.116, 95% CI 1.116-1.220, p value < 0.001); NRTI backbone (D4T-based: aHR = 1.849, 95% CI 1.449-2.360, p value < 0.001) were associated with increased cumulative hazard of treatment modification. Baseline weight (aHR = 0.996, 95% CI 0.993-0.999, p value = 0.013); address within Maekel (aHR = 0.854, 95% CI 0.774-0.942, p value = 0.002); AZT-based backbones (aHR = 0.654, 95% CI 0.515-0.830, p value < 0.001); TDF-based backbones: aHR = 0.068, 95% CI 0.051-0.091, p value < 0.001), NVP-based anchors (aHR = 0.889, 95% CI 0.806-0.980, p value = 0.018) were associated with lower cumulative hazards of attrition. The minimal number of switching suggests inadequate VL testing. However, the large number of toxicity/intolerance and drug-shortage driven substitutions highlight important problems in this setting. Consequently, the need to advocate for both sustainable access to safer ARVs in SSA and improvements in local supply chains is warranted.

1081. Challenging the Kauzmann paradox using an ultra-stable perfluoropolymer glass with a fictive temperature below the dynamic VFT temperature.

Sci Rep

2023 Mar 14

El Banna AA, McKenna GB.

1082. Synthesis of activated carbon composited with Egyptian black sand for enhanced adsorption performance toward methylene blue dye.

Sci Rep

2023 Mar 14

Elkholy AS, Yahia MS, Elnwawy MA

1083. Analytical and clinical validity of wearable, multi-sensor technology for assessment of motor function in patients with Parkinson's disease in Japan.

Sci Rep

2023 Mar 14

Oyama G(#), Burq M(#), Hatano T

1084. Altered norepinephrine transmission after spatial learning impairs sleep-mediated memory consolidation in rats.

Sci Rep

2023 Mar 14

Durán E, Pandinelli M, Logothetis NK

1085. A three-plasma miRNA panel predicts the risk of colorectal cancer: a community-based nested case‒control study.

Sci Rep

2023 Mar 14

Liu J(#), Chen B(#), Yang M

1086. Influence of the emulsifier on nanostructure and clinical application of liquid crystalline emulsions.

Sci Rep

2023 Mar 14

Teeranachaideekul V, Soontaranon S, Sukhasem S

Liquid crystals are appealing in pharmaceutical and cosmetic fields due to their unique structures that combine the properties of both liquid and solid states. Forming an emulsion into liquid crystals can be affected by a number of factors, including the emulsion composition and temperature. Changing the types and concentrations of surfactants could be another factor that affects liquid crystals. Currently, most liquid crystal research focuses on the nanostructure of liquid crystal systems without evaluating the efficacy of liquid crystals clinically. In this study, liquid crystalline emulsions made from camellia seed oil with four different surfactants (Olivem 1000, Polyaquol-2W, Nikkomulese LC, and Lecinol S-10 with Tween 80) were created. The liquid crystal emulsions were formulated in the form of oil-in-water (o/w) emulsions with Camellia oleifera seed oil serving as the main ingredient in the oil phase (10% w/w). All formulations exhibited liquid crystal characteristics with lamellar structures as determined by the polarized light microscopy and small-angle X-ray scattering with supporting data of the nanostructure from wide-angle X-ray scattering and differential scanning calorimetry (DSC). They all showed good stability under normal (room temperature) and accelerated conditions (4 °C and 40 °C) in long-term storage (6 months). Using the reconstructed human epidermis as a skin model, all formulations did not cause skin irritation. In the clinical trial, all formulations were able to reduce transepidermal water loss (TEWL) and increase skin hydration immediately after application. This lasted at least 10 h. All formulations showed distinct Maltese crosses under the polarized light microscope with a positive result for liquid crystals in wide angle X-ray scattering (WAXS) and small angle X-ray scattering (SAXS) methods. Moreover, among all formulations tested, Formulation D, which contained Lecinol S-10 and Tween 80 as emulsifiers, showed the most robust interaction between the surfactant and water molecules in the lamellar structure under DSC. The formulation was stable in long-term normal and accelerated conditions. Above all, Formulation D, which was formulated with Lecinol S-10 with Tween 80, had the best clinical result, was nonirritating to the skin, and can be used as a cream base in the pharmaceutical and cosmeceutical sectors.

1087. Characterization of human anti-EpCAM antibodies for developing an antibody-drug conjugate.

Sci Rep

2023 Mar 14

Satofuka H(#), Wang Y(#), Yamazaki K(#)

1088. Detection of Escherichia coli O157:H7 in imported meat products from Saudi Arabian ports in 2017.

Sci Rep

2023 Mar 14

Alhadlaq MA, Mujallad MI, Alajel SMI.

1089. Surveillance of Vibrio parahaemolyticus pathogens recovered from ready-to-eat foods.

Sci Rep

2023 Mar 14

Beshiru A, Igbinosa EO.

1090. An integrated evaluation approach of wearable lower limb exoskeletons for human performance augmentation.

Sci Rep

2023 Mar 14

Zhang X, Chen X, Huo B

Wearable robots have been growing exponentially during the past years and it is crucial to quantify the performance effectiveness and to convert them into practical benchmarks. Although there exist some common metrics such as metabolic cost, many other characteristics still needs to be presented and demonstrated. In this study, we developed an integrated evaluation (IE) approach of wearable exoskeletons of lower limb focusing on human performance augmentation. We proposed a novel classification of trial tasks closely related to exoskeleton functions, which were divided into three categories, namely, basic trial at the preliminary phase, semi-reality trial at the intermediate phase, and reality trial at the advanced phase. In the present study, the IE approach has been exercised with a subject who wore an active power-assisted knee (APAK) exoskeleton with three types of trial tasks, including walking on a treadmill at a certain angle, walking up and down on three-step stairs, and ascending in 11-storey stairs. Three wearable conditions were carried out in each trial task, i.e. with unpowered exoskeleton, with powered exoskeleton, and without the exoskeleton. Nine performance indicators (PIs) for evaluating performance effectiveness were adopted basing on three aspects of goal-level, task-based kinematics, and human-robot interactions. Results indicated that compared with other conditions, the powered APAK exoskeleton make generally lesser heart rate (HR), Metabolic equivalent (METs), biceps femoris (BF) and rectus femoris (RF) muscles activation of the subject at the preliminary phase and intermediate phase, however, with minimal performance augmentation at advanced phase, suggesting that the APAK exoskeleton is not suitable for marketing and should be further improved. In the future, continuous iterative optimization for the IE approach may help the robot community to attain a comprehensive benchmarking methodology for robot-assisted locomotion more efficiently.

1091. Mindfulness may be associated with less prosocial engagement among high intelligence individuals.

Sci Rep

2023 Mar 14

Guo Q, Li S, Liang J

1092. Histological and transcriptomic analysis of muscular atrophy associated with depleted flesh pigmentation in Atlantic salmon (Salmo salar) exposed to elevated seawater temperatures.

Sci Rep

2023 Mar 14

Vo TTM, Amoroso G, Ventura T

Tasmania is experiencing increasing seawater temperatures during the summer period which often leads to thermal stress-induced starvation events in farmed Atlantic salmon, with consequent flesh pigment depletion. Our previous transcriptomic studies found a link between flesh pigmentation and the expression of genes regulating lipid metabolism accompanied by feeding behavior in the hindgut. However, the impact of prolonged exposure to elevated water temperature on muscle structural integrity and molecular mechanisms in muscle underlying pigment variation has not been elucidated to date. In this study, we investigated the effect of prolonged exposure to elevated water temperature on the farmed salmon flesh pigmentation and structural integrity, using muscle histological and transcriptomic analysis. On April 2019, after the end of the summer, two muscle regions of the fish fillet, front dorsal and back central (usually the most and least affected by depletion, respectively), were sampled from fifteen fish (weighing approximately 2 kg and belonging to the same commercial population split in two cages). The fish represented three flesh color intensity groups (n = 5 fish per group) categorized according to general level of pigmentation and presence of banding (i.e. difference in color between the two regions of interest) as follows: high red color-no banding (HN), high red color-banded (HB) and Pale fish. Histological analysis showed a distinction between the flesh color intensity phenotypes in both muscle regions. Muscle fibers in the HB fish were partly degraded, while they were atrophied and smaller in size in Pale fish compared to HN fish. In the Pale fish, interstitial spaces between muscle fibers were also enlarged. Transcriptomic analysis showed that in the front dorsal region of the HN fish, genes encoding collagens, calcium ion binding and metabolic processes were upregulated while genes related to lipid and fatty acid metabolism were downregulated when compared to HB fish. When comparing the back central region of the three phenotypes, actin alpha skeletal muscle and myosin genes were upregulated in the HN and HB fish, while tropomyosin genes were upregulated in the Pale fish. Also, genes encoding heat shock proteins were upregulated in the HN fish, while genes involving lipid metabolism and proteolysis were upregulated in the Pale fish. Starvation, likely caused by thermal stress during prolonged periods of elevated summer water temperatures, negatively affects energy metabolism to different extents, leading to localized or almost complete flesh color depletion in farmed Atlantic salmon. Based on our results, we conclude that thermal stress is responsible not only for flesh discoloration but also for loss of muscle integrity, which likely plays a key role in pigment depletion.

1093. Isolation, characterization, proteome, miRNAome, and the embryotrophic effects of chicken egg yolk nanovesicles (vitellovesicles).

Sci Rep

2023 Mar 14

Saadeldin IM, Tanga BM, Bang S

Egg yolk constitutes about a third of the structure of the chicken egg however, the molecular structure and physiological effects of egg yolk-derived lipid membranous vesicles are not clearly understood. In this study, for the first record, the egg yolk nanovesicles (vitellovesicles, VVs) were isolated, characterized, and used as a supplement for porcine embryo culture. Yolks of ten freshly oviposited eggs were filtered and ultracentrifuged at 100,000 × g for 3 h to obtain a pellet. Cryogenic transmission electron microscopy and nanoparticle tracking analysis of the pellet revealed bilipid membranous vesicles. Protein contents of the pellet were analyzed using tandem mass spectrometry and the miRNA content was also profiled through BGISEQ-500 sequencer. VVs were supplemented with the in vitro culture medium of day-7 hatched parthenogenetic blastocysts. After 2 days of blastocyst culture, the embryonic cell count was increased in VVs supplemented embryos in comparison to the non-supplemented embryos. TUNEL assay showed that apoptotic cells were increased in control groups when compared with the VVs supplemented group. Reduced glutathione was increased by 2.5 folds in the VVs supplemented group while reactive oxygen species were increased by 5.3 folds in control groups. Quantitative PCR analysis showed that VVs significantly increased the expression of lipid metabolism-associated genes (monoglyceride lipase and lipase E), anti-apoptotic gene (BCL2), and superoxide dismutase, while significantly reducing apoptotic gene (BAX). Culturing embryos on Matrigel basement membrane matrix indicated that VVs significantly enhanced embryo attachment and embryonic stem cell outgrowths compared to the non-supplemented group. This considers the first report to characterize the molecular bioactive cargo contents of egg yolk nanovesicles to show their embryotrophic effect on mammalian embryos. This effect might be attributed to the protein and miRNA cargo contents of VVs. VVs can be used for the formulation of in vitro culture medium for mammalian embryos including humans.

1094. Laser-driven low energy electron beams for single-shot ultra-fast probing of meso-scale materials and warm dense matter.

Sci Rep

2023 Mar 14

Falk K(#), Šmíd M(#), Boháček K

1095. On the stability & phase locking to a system reference of an optoelectronic oscillator with large delay.

Sci Rep

2023 Mar 14

Hasan M, Nicholls C, Hall T.

1096. A cognitive behaviour data analysis on the use of social media in global south context focusing on Bangladesh.

Sci Rep

2023 Mar 14

Samya SSR, Tonmoy MDSI(#), Rabbi MDF(#).

1097. Recursive bit assignment with neural reference adaptive step (RNA) MPPT algorithm for photovoltaic system.

Sci Rep

2023 Mar 14

Hegazy E, Shokair M, Saad W.

1098. Robotic automation and unsupervised cluster assisted modeling for solving the forward and reverse design problem of paper airplanes.

Sci Rep

2023 Mar 14

Obayashi N, Junge K, Ilić S

1099. Intense multicycle THz pulse generation from laser-produced nanoplasmas.

Sci Rep

2023 Mar 14

Kumar M, Song HS, Lee J

1100. Effects of copal resin extraction on the diversity and composition of species in tropical deciduous forests.

Sci Rep

2023 Mar 14

García-Núñez RM, Buendía-Espinoza JC, Del Carmen Arrazate-Jiménez S

1101. Genome editing of the vermilion locus generates a visible eye color marker for Oncopeltus fasciatus.

Sci Rep

2023 Mar 14

Reding K, Lê M, Pick L.

1102. Polarity and mixed-mode oscillations may underlie different patterns of cellular migration.

Sci Rep

2023 Mar 14

Plazen L, Rahbani JA, Brown CM

In mesenchymal cell motility, several migration patterns have been observed, including directional, exploratory and stationary. Two key members of the Rho-family of GTPases, Rac and Rho, along with an adaptor protein called paxillin, have been particularly implicated in the formation of such migration patterns and in regulating adhesion dynamics. Together, they form a key regulatory network that involves the mutual inhibition exerted by Rac and Rho on each other and the promotion of Rac activation by phosphorylated paxillin. Although this interaction is sufficient in generating wave-pinning that underscores cellular polarization comprised of cellular front (high active Rac) and back (high active Rho), it remains unclear how they interact collectively to induce other modes of migration detected in Chinese hamster Ovary (CHO-K1) cells. We previously developed a six-variable (6V) reaction-diffusion model describing the interactions of these three proteins (in their active/phosphorylated and inactive/unphosphorylated forms) along with other auxiliary proteins, to decipher their role in generating wave-pinning. In this study, we explored, through computational modeling and image analysis, how differences in timescales within this molecular network can potentially produce the migration patterns in CHO-K1 cells and how switching between migration modes could occur. To do so, the 6V model was reduced to an excitable 4V spatiotemporal model possessing three different timescales. The model produced not only wave-pinning in the presence of diffusion, but also mixed-mode oscillations (MMOs) and relaxation oscillations (ROs). Implementing the model using the Cellular Potts Model (CPM) produced outcomes in which protrusions in the cell membrane changed Rac-Rho localization, resulting in membrane oscillations and fast directionality variations similar to those observed experimentally in CHO-K1 cells. The latter was assessed by comparing the migration patterns of experimental with CPM cells using four metrics: instantaneous cell speed, exponent of mean-square displacement ([Formula: see text]-value), directionality ratio and protrusion rate. Variations in migration patterns induced by mutating paxillin's serine 273 residue were also captured by the model and detected by a machine classifier, revealing that this mutation alters the dynamics of the system from MMOs to ROs or nonoscillatory behaviour through variation in the scaled concentration of an active form of an adhesion protein called p21-Activated Kinase 1 (PAK). These results thus suggest that MMOs and adhesion dynamics are the key mechanisms regulating CHO-K1 cell motility.

1103. A laser-induced mouse model of progressive retinal degeneration with central sparing displays features of parafoveal geographic atrophy.

Sci Rep

2023 Mar 14

Khan AH(#), Soundara Pandi SP(#), Scott JA

1104. Design and fabrication of a Wilkinson power divider with harmonic suppression for LTE and GSM applications.

Sci Rep

2023 Mar 14

Moloudian G, Soltani S, Bahrami S

1105. The curcumin analogue PAC has potent anti-anaplastic thyroid cancer effects.

Sci Rep

2023 Mar 14

Al-Mohanna M, Alraouji NN, Alhabardi SA

1106. A novel ex-vivo isolated rabbit heart preparation to explore the cardiac effects of cervical and cardiac vagus nerve stimulation.

Sci Rep

2023 Mar 14

Kronsteiner B, Haberbusch M, Aigner P

1107. Comparison of carcass condemnation causes in two broiler hybrids differing in growth rates.

Sci Rep

2023 Mar 14

Forseth M, Moe RO, Kittelsen K

1108. Presence of non-symbiotic yeasts in a symbiont-transferring organ of a stag beetle that lacks yeast symbionts found in other stag beetles.

Sci Rep

2023 Mar 14

Yamamoto D(#), Toki W(#).

Dispersal from wood to wood is essential for wood-inhabiting fungi and wood-inhabiting insects play an important role in the dispersal success of such fungi. However, it is poorly understood whether wood-inhabiting insects which change the habitats from wood to non-wood environments can contribute to the fungal dispersal. Larvae of most stag beetles (Coleoptera: Lucanidae) are wood feeders, while adults are sap feeders. Female adults of lulcanids possess specialized organs (mycetangia) for transportation of fungal symbionts and harbor specific yeasts (e.g., Scheffersomyces spp.) within. Here, we report that the lucanid Aegus subnitidus harbors non-specific yeasts facultatively in mycetangia. We conducted yeast isolation from mycetangia and hindguts of female adults, in a larval gallery in wood-associated materials, and in female-visiting fermented tree sap using culture-dependent methods. Less than half of the females carried a total of 20 yeast species with small amounts using mycetangia and a female harbored up to five species, suggesting the absence of an intimate association with specific yeasts that are found in other lucanids. Yeast species compositions markedly differed between the larval gallery and sap. Most yeasts from the larval galley exhibited xylose-assimilation abilities, while few yeasts from sap did. Mycetangial yeasts comprised a combination from both sources. In hindguts, most yeasts were found in sap (> 70%) with no yeasts in the larval gallery. Sap-associated yeasts in each female mycetangium were also obtained from the female-visiting sap patch, while mycetangial, larval gallery-associated yeasts were absent from the patch, suggesting the survival success of larval gallery-associated yeasts in mycetangia through sap patches. Therefore, wood-inhabiting insects that possess mycetangia can potentially act as vectors of non-symbiotic wood-inhabiting yeasts dispersing from wood to wood via other environments.

1109. National and sub-national burden and trend of type 1 diabetes in 31 provinces of Iran, 1990-2019.

Sci Rep

2023 Mar 14

Bandarian F(#), Sharifnejad Tehrani Y(#), Peimani M

1110. Rapid oxidative fragmentation of polypropylene with pH control in seawater for preparation of realistic reference microplastics.

Sci Rep

2023 Mar 14

Nakatani H, Ohshima Y, Uchiyama T

1111. Molecular testing devices for on-site detection of E. coli in water samples.

Sci Rep

2023 Mar 14

Manzanas C, Morrison E, Kim YS

1112. Urinary bio-monitoring of aromatic amine derivatives by new needle trap device packed with the multi-component adsorbent.

Sci Rep

2023 Mar 14

Rahimpoor R, Murtada K, Firoozichahak A

Aromatic amines are a large group of chemical compounds that have attracted the attention of researchers due to their toxicity and carcinogenicity. This study aimed to develop an efficient method for sampling and analysis of aromatic amines (Aniline, N, N-dimethylaniline, 2-chloroaniline, and 3-chloroaniline) from the vapour phase (headspace) of urine samples. For the implementation of this plan, a needle trap device packed with the three-component adsorbent consisting of nano-Hydroxy Apatite (nHA), Zeolite (Ze), and Metal-Organic Framework (MOF) equipped with GC-FID was employed for the first phase. Examination of the prepared adsorbents was performed by FT-IR, PXRD, and FE-SEM techniques. The optimal value of considerable parameters such as time and temperature of extraction, salt content, and pH were established using the Response Surface Methodology-Central Composite Design (RMS-CCD) method. In this way, the optimal extraction of targeted analytes was accomplished in 41 min at 41 °C with NaCl content of 33.0% (w/v) and pH: 13.0, respectively. Also, the repeatability and reproducibility of the method were calculated to be in the range of 2.2-7.1% and 3.9-8.1%, respectively, which indicates the acceptable precision of the method. Also, the limit of detection (LOD) and limit of quantification (LOQ) were determined in the range of 0.3-32.0 ng.L-1 and 0.8-350.0 ng.L-1, respectively, which proves the high sensitivity of the proposed method. Furthermore, the recovery percent of the extracted analytes was concluded in the range of 97.0-99.0% after 6 and 30 days of the sampling and storage at 25 °C and 4 °C, respectively. Finally, the designed procedure was employed in the analysis of the above-mentioned aromatic amines in the real urine samples. The achieved results illustrate that the three-component absorbent system (nHA;Ze;MOF@NTD) can be introduced as an efficient, fast-response, sensitive, and versatile procedure for trace analysis of the different aromatic amine compounds in public and occupational health.

1113. Both whole-body rotation and visual flow induce cardiovascular autonomic response in human, but visual response is overridden by vestibular stimulation.

Sci Rep

2023 Mar 14

Kuldavletova O, Denise P, Normand H

1114. First-principle study on the stability of Cd passivates in soil.

Sci Rep

2023 Mar 14

Shen J, Li J, Mao Z

1115. Histologic and histomorphometric evaluation of Aloe vera adjunctive to β-tricalcium phosphate in class II furcation defects in dogs.

Sci Rep

2023 Mar 14

Taalab MR, Rehim SSAE, Eldeeb DW

1116. Thermography and rasterstereography as a combined infrared method to assess the posture of healthy individuals.

Sci Rep

2023 Mar 14

Roggio F, Petrigna L, Trovato B

1117. On the role of inhibition in suppression-induced forgetting.

Sci Rep

2023 Mar 14

van Schie K, Fawcett JM, Anderson MC.

1118. Adaptive control for downhole nuclear magnetic resonance excitation.

Sci Rep

2023 Mar 14

Shi G, Xiao L, Luo S

1119. The occurrence of pristine and functionalized fullerenes as constituents of airborne aerosols.

Sci Rep

2023 Mar 14

Dos Santos FN(#), Nascimento MM(#), da Rocha GO(#)

1120. Extraction-free clinical detection of SARS-CoV-2 virus from saline gargle samples using Hamilton STARlet liquid handler.

Sci Rep

2023 Mar 14

Gadkar VJ, Goldfarb DM, Al-Rawahi GN

1121. Load bearing capacity of arch structure in unconsolidated layers.

Sci Rep

2023 Mar 14

Wang F, Zhu W, Jie Z

Coal mining inevitably results in the movement of overlying strata, with the upward formation of the strata leading to surface subsidence, causing irreversible impact on the buildings, land, and ecological environment. The movement and deformation of the strata are controlled by the bearing structure in the overlying strata, whose failure results in the deformation and breakage of the overlying strata simultaneously. While studies have been conducted on the arch structure in unconsolidated layers (ASUL), its bearing performance has not been addressed. Therefore, this study develops a bearing mechanics model based on the morphological characteristics of the ASUL. The analytical expressions of the axial force, bending moment, and shear force of the cross-sectional area were determined using theoretical derivations. The model analysed the internal forces and showed the influence laws of the overlying load, horizontal pressure coefficient, and rise-to-span ratio of the ASUL. The failure criterion of the bearing was also further determined. The results indicated that with overlying and horizontal loads, the axial force and bending moment are symmetrically distributed, whereas the shear force is asymmetrically distributed. In addition, the axial force gradually increases from the dome to the base of the ASUL. Compared to the axial force and bending moment, the shear force has a lower impact on the stability of the ASUL. Most of the axial force and overlying load is received through the axial compression of the cross-section to maintain stability and play a bearing role on the overlying unconsolidated layers. As the overlying load, horizontal pressure coefficient, and rise-to-span ratio increase, the axial force, bending moment, and shearing force also increase gradually. This effect is more apparent at the dome, spandrel, and base of the ASUL. The stability of the dome and spandrel is key to the overall structural stability. Therefore, the failure criterion for the ASUL was determined based on the compression failure at the dome and spandrel. During the mining process of the working face, the ASUL served as load-bearing control for the overlying unconsolidated layers. Further, increasing width of the working face damages and shifts the base of the ASUL, resulting in compression failure at the dome and spandrel, further inducing dome lift and causing overall failure of the ASUL. Considering the aforementioned factors, a control method that reinforces the surface subsidence of the ASUL by 'one-time, upward, staged, and multiple-ground-drilling' compaction grouting has been proposed. During the mining process of the working face, the arch bead-like structure, combined with the ASUL, serves as the load-bearing control on the overlying strata and ground surface, reducing ASUL deformation in the unconsolidated layers, overlying strata, and ground surface. This process enables the controlling of ground subsidence of coal mining in thick unconsolidated layers.

1122. Arsenic causing gallbladder cancer disease in Bihar.

Sci Rep

2023 Mar 14

Kumar A, Ali M, Raj V

1123. Cadmium and lead ions adsorption on magnetite, silica, alumina, and cellulosic materials.

Sci Rep

2023 Mar 14

Wonorahardjo S, Fajaroh F, Joharmawan R

1124. Biomolecular and quantum algorithms for the dominating set problem in arbitrary networks.

Sci Rep

2023 Mar 14

Wong R, Chang WL, Chung WY

1125. Serum concentration of zinc, copper, iron, and its associated factors among pregnant women of small-scale farming in western Ethiopia.

Sci Rep

2023 Mar 14

Afata TN, Mekonen S, Tucho GT.

Micro-nutrients are required in small amounts to maintain growth and cell functioning to complete the life cycle through reproductions. However, pregnant women in developing countries like Ethiopia are vulnerable to multiple micro-nutrient deficiencies. Therefore, this study aimed at assessing the serum level of metals and associated factors like dietary diversity, and health-related problems in pregnant women among small-scale farming in Kellem Wellega, western Ethiopia. A cross-sectional laboratory-based study was conducted from June to August 2021 on 417 pregnant women attending antenatal care at rural healthcare facilities. Data was collected by using per-tested structured questionnaires via face-to-face interviews. The data analysis was conducted using SPSS version 24.0, and multivariate logistic regression analysis was performed to determine the association between predictor and outcome variables. A statistically significant was considered at p value < 0.05 for all the analyses. Our study findings showed that 62.1, 80.9, and 71.9% of the participants were deficient in iron, zinc, and copper micro-nutrient levels, respectively. Pregnant women who could not have formal education were 3.24 (AOR = 3.24, 95% CI 1.33-7.91) and 3.98 (AOR = 3.98, 95% CI 1.2-13.15) times more likely to show zinc and copper deficiency than those who attended secondary school and above, respectively. Furthermore, pregnant women involved only in farming activities were 0.57 (AOR = 0.57, 95% CI 0.36-0.91) and 4.33 (AOR = 5.72, 95% CI 2.34-13.97) times more likely to be exposed to iron and zinc deficiency than those who were engaged in other activities. This study revealed that pregnant women with low income were 6.36 times more likely to be exposed to zinc micro-nutrient deficiencies than those with high-income participants (AOR = 6.36, 95% CI 1.47-27.61). Additionally, those participants who ate a varied diet between 1 and 4 items per day were 2.26 (AOR = 2.26, 95% CI 1.43-3.59) and 2.77 (AOR = 2.77, 95% CI 1.6-4.61) times more likely to suffer zinc and copper micro-nutrient insufficiency than those who consumed 5-10 items per day. Finally, pregnant women who developed diarrhea in the past three months were 1.82 (AOR = 2.77, 95% CI 1.14-2.92) and 2.52 (AOR = 2.52, 95% CI 1.3-4.91) times more likely to be exposed to iron and copper deficiency than those who never show the symptoms, respectively. This study identified low concentrations of zinc, iron, and copper in the blood serum of pregnant women of small-scale farmers.

1126. Screening of potential immune-related genes expressed during sepsis using gene sequencing technology.

Sci Rep

2023 Mar 14

Tian Y(#), Wang C(#), Lu Q

1127. Risk factors for, and prediction of, exertional heat illness in Thoroughbred racehorses at British racecourses.

Sci Rep

2023 Mar 14

Trigg LE, Lyons S, Mullan S.

1128. Post-truth epistemic beliefs rooted in the Dark Factor of Personality are associated with higher COVID-19 vaccination refusal.

Sci Rep

2023 Mar 14

Rudloff JP, Hutmacher F, Appel M.

1129. Universal scaling laws and density slopes for dark matter haloes.

Sci Rep

2023 Mar 13

Xu Z.

1130. Screening and identification of key biomarkers of depression using bioinformatics.

Sci Rep

2023 Mar 13

Kong X, Wang C, Wu Q

1131. Effects of Thymbra capitata essential oil on in vitro fermentation end-products and ruminal bacterial communities.

Sci Rep

2023 Mar 13

Ranilla MJ, Andrés S, Gini C

1132. Development of novel broad-spectrum antimicrobial lipopeptides derived from plantaricin NC8 β.

Sci Rep

2023 Mar 13

Wiman E, Zattarin E, Aili D

1133. Blind spectral unmixing for characterization of plaque composition based on multispectral photoacoustic imaging.

Sci Rep

2023 Mar 13

Cano C, Matos C, Gholampour A

1134. Gecko-inspired self-adhesive packaging for strain-free temperature sensing based on optical fibre Bragg gratings.

Sci Rep

2023 Mar 13

Liu S, Zhu P, Xie F

1135. Gender disparities in prevalence by diagnostic criteria, treatment and mortality of newly diagnosed acute myocardial infarction in Korean adults.

Sci Rep

2023 Mar 13

Kim SR(#), Bae S(#), Lee JY

1136. Evidence that the aesthetic preference for Hogarth's Line of Beauty is an evolutionary by-product.

Sci Rep

2023 Mar 13

Hübner R, Lewis DMG, Al-Shawaf L

1137. Exact Gaussian processes for massive datasets via non-stationary sparsity-discovering kernels.

Sci Rep

2023 Mar 13

Noack MM, Krishnan H, Risser MD

1138. Exogenous melatonin induces phenolic compounds production in Linum album cells by altering nitric oxide and salicylic acid.

Sci Rep

2023 Mar 13

Esmaeili S, Sharifi M, Ghanati F

1139. Nickel substituted polyoxometalates in layered double hydroxides as metal-based nanomaterial of POM-LDH for green catalysis effects.

Sci Rep

2023 Mar 13

Ghiasi Moaser A, Afkham AG, Khoshnavazi R

1140. Differentiating malignant and benign eyelid lesions using deep learning.

Sci Rep

2023 Mar 13

Lee MJ(#), Yang MK(#), Khwarg SI

1141. Study on stress variation of advance fiberglass anchor bolts during tunnel excavation process.

Sci Rep

2023 Mar 13

Feng J, Tan Y, Yao S

1142. A multicentre study reveals dysbiosis in the microbial co-infection and antimicrobial resistance gene profile in the nasopharynx of COVID-19 patients.

Sci Rep

2023 Mar 13

Mahmud ASM, Seers CA, Shaikh AA

1143. Early exploitation of Neapolitan pozzolan (pulvis puteolana) in the Roman theatre of Aquileia, Northern Italy.

Sci Rep

2023 Mar 13

Dilaria S, Secco M, Ghiotto AR

1144. DRLBTS: deep reinforcement learning-aware blockchain-based healthcare system.

Sci Rep

2023 Mar 13

Lakhan A, Mohammed MA, Nedoma J

1145. Fiber enhancement and 3D orientation analysis in label-free two-photon fluorescence microscopy.

Sci Rep

2023 Mar 13

Sorelli M, Costantini I, Bocchi L

1146. Compensatory gene expression potentially rescues impaired brain development in Kit mutant mice.

Sci Rep

2023 Mar 13

Minei R, Aoki H, Ogura A

1147. Novel estimation technique for the carrier-to-noise ratio of wireless medical telemetry using software-defined radio with machine-learning.

Sci Rep

2023 Mar 13

Kai I.

1148. Experimental study on collapsible and structural characteristics of artificially prepared loess material.

Sci Rep

2023 Mar 13

Zhang Y, Song Z, Chen H

Collapsibility and structural are two of the typical characteristics of natural undisturbed loess. It is of great significance to effectively simulate the collapsibility and structural of natural loess by preparing artificially loess. However, the existing methods of artificially preparing collapsible loess are complex, and the collapsibility of the prepared samples is difficult to control. In this paper, the collapsibility mechanism of loess was re-analyzed, and on this basis, a new method for preparing artificial collapsible loess using remolded loess, industrial salt, CaO particles and gypsum powder was proposed. The basic principle is: the CaO particles have structural strength and would transfer to Ca(OH)2 after soaking, this progress can simulate the disappearance of loess structural strength; The dissolution of industrial salt can simulate the collapse of loess internal pores, the collapsibility of artificial loess can be adjusted by adjusting the percentage of industrial salt; the gypsum powder can simulate the cementation of loess as a bonding material. The shear test, consolidation test and collapsibility test of artificially prepared loess and undisturbed loess were carried out. The test results of artificial loess were compared with undisturbed loess. The results show that: the plastic limit and liquid limit of the artificially prepared loess is smaller than that of the undisturbed loess; The optimal moisture content and maximum dry density are close to that of the undisturbed loess; The collapsibility coefficient of artificial prepared samples increases first and then decreases with the increase of load level, and gradually increases with the increase of industrial salt particle content; The structural parameters of artificially prepared loess samples first increase and then decrease with the shear process, but the structural parameters of artificial prepared loess and undisturbed loess are different under different confining pressure conditions.

1149. Benchmarking machine learning robustness in Covid-19 genome sequence classification.

Sci Rep

2023 Mar 13

Ali S, Sahoo B, Zelikovsky A

1150. Top-down and bottom-up effects modulate species co-existence in a context of top predator restoration.

Sci Rep

2023 Mar 13

Burgos T, Salesa J, Fedriani JM

1151. Effects of social deprivation on risk factors for suicidal ideation and suicide attempts in commercially insured US youth and adults.

Sci Rep

2023 Mar 13

Xi W, Banerjee S, Olfson M

1152. Research on main influencing factors and complete support technology for dynamic pressure and large deformation roadway.

Sci Rep

2023 Mar 13

Rong H, Guo K, Sun D

To determine the main factors influencing dynamic pressure and large deformation roadways, a targeted set of support technologies was designed. The 2603 air inlet roadway of the Zhangcun coal mine in Lu'an, Shanxi Province, was taken as an example. The influence of the Wenwangshan South normal fault and in situ stress field on the dynamic pressure roadway was analyzed theoretically, and the main factors influencing this dynamic pressure and large deformation roadway under natural geological conditions were determined. The effect of the existing roadway support scheme was evaluated by field test methods such as nondestructive bolt testing. The influence of mining two working faces on the dynamic pressure and large deformation roadway was studied by the FLAC3D numerical simulation method. On this basis, a new grouting material was developed, a complete set of technical schemes of full-section integrated cooperative support of dynamic pressure and large deformation roadways was proposed, and the field application effect was verified. The results showed that under natural geological conditions, the 2603 air inlet roadway was located within the influence range of the Wenwangshan South normal fault, which was significantly affected and controlled by the fault. The included angle between the roadway extension direction and the maximum principal stress was 74°, which was not conducive to the stability of the roadway. The range of the roadway loose zone was large. Under the existing support conditions, the surrounding rock could not form a relatively stable structure, which was one of the main reasons for the large deformation of the surrounding rock in the dynamic pressure roadway. The 2603 air inlet roadway was affected by the mining of both the adjacent working face and the 2603 working face. The stresses were superimposed, and the roadway was greatly deformed and damaged. A new grouting material was developed. A crosslinking agent prepared by toluene diisocyanate and polyether polyol was added to the existing polyurethane material to form a new grouting material, and a complete supporting technical scheme was proposed. The field application results showed that the displacement and floor heave of both sides of the roadway were reduced by approximately 87%, the deformation and failure of the coal and rock mass of the roadway were effectively controlled, and the deformation of the dynamic pressure roadway was greatly reduced.

1153. Imaging analysis and predictive nomogram construction for degenerative lumbar spondylolisthesis with severe clinical symptom based on propensity score matching.

Sci Rep

2023 Mar 13

He Y, Wang W, Zhou H

1154. Optimization of shadow evaporation and oxidation for reproducible quantum Josephson junction circuits.

Sci Rep

2023 Mar 13

Moskalev DO, Zikiy EV, Pishchimova AA

1155. Renal toxicity and biokinetics models after repeated uranium instillation.

Sci Rep

2023 Mar 13

De Castro L, Manoury A, Claude O

1156. Natural history of nonhuman primates after conjunctival exposure to Ebola virus.

Sci Rep

2023 Mar 13

Cross RW, Prasad AN, Woolsey CB

1157. Myo1e overexpression in lung adenocarcinoma is associated with increased risk of mortality.

Sci Rep

2023 Mar 13

Jusue-Torres I(#), Tiv R(#), Ricarte-Filho JC

1158. Stress native T1 and native T2 mapping compared to myocardial perfusion reserve in long-term follow-up of severe Covid-19.

Sci Rep

2023 Mar 13

Nickander J, Steffen Johansson R, Lodin K

1159. Antibacterial efficacy of synthesized silver nanoparticles of Microbacterium proteolyticum LA2(R) and Streptomyces rochei LA2(O) against biofilm forming meningitis causing microbes.

Sci Rep

2023 Mar 13

Bano N, Iqbal D, Al Othaim A

1160. Neural oscillatory characteristics of feedback-associated activity in globus pallidus interna.

Sci Rep

2023 Mar 13

Choubdar H(#), Mahdavi M(#), Rostami Z(#)

1161. The role of additive and diffusive coupling on the dynamics of neural populations.

Sci Rep

2023 Mar 13

Lopes MA, Hamandi K, Zhang J

Dynamical models consisting of networks of neural masses commonly assume that the interactions between neural populations are via additive or diffusive coupling. When using the additive coupling, a population's activity is affected by the sum of the activities of neighbouring populations. In contrast, when using the diffusive coupling a neural population is affected by the sum of the differences between its activity and the activity of its neighbours. These two coupling functions have been used interchangeably for similar applications. In this study, we show that the choice of coupling can lead to strikingly different brain network dynamics. We focus on a phenomenological model of seizure transitions that has been used both with additive and diffusive coupling in the literature. We consider small networks with two and three nodes, as well as large random and scale-free networks with 64 nodes. We further assess resting-state functional networks inferred from magnetoencephalography (MEG) from people with juvenile myoclonic epilepsy (JME) and healthy controls. To characterize the seizure dynamics on these networks, we use the escape time, the brain network ictogenicity (BNI) and the node ictogenicity (NI), which are measures of the network's global and local ability to generate seizure activity. Our main result is that the level of ictogenicity of a network is strongly dependent on the coupling function. Overall, we show that networks with additive coupling have a higher propensity to generate seizures than those with diffusive coupling. We find that people with JME have higher additive BNI than controls, which is the hypothesized BNI deviation between groups, while the diffusive BNI provides opposite results. Moreover, we find that the nodes that are more likely to drive seizures in the additive coupling case are more likely to prevent seizures in the diffusive coupling case, and that these features correlate to the node's number of connections. Consequently, previous results in the literature involving such models to interrogate functional or structural brain networks could be highly dependent on the choice of coupling. Our results on the MEG functional networks and evidence from the literature suggest that the additive coupling may be a better modeling choice than the diffusive coupling, at least for BNI and NI studies. Thus, we highlight the need to motivate and validate the choice of coupling in future studies involving network models of brain activity.

1162. Risks of organ failures and deaths associated with young-onset dementia after hospitalizations for motor vehicle crash injuries: a nationwide population-based retrospective cohort study.

Sci Rep

2023 Mar 13

Liu CH, Wang JY, Chang KC

1163. New insights into APCVD grown monolayer MoS(2) using time-domain terahertz spectroscopy.

Sci Rep

2023 Mar 13

Sharma S, Chauhan P, Rane S

1164. Advanced quantum image representation and compression using a DCT-EFRQI approach.

Sci Rep

2023 Mar 13

Haque ME, Paul M, Ulhaq A

1165. Consequences of reprogramming acetyl-CoA metabolism by 2,3,7,8-tetrachlorodibenzo-p-dioxin in the mouse liver.

Sci Rep

2023 Mar 13

Cholico GN, Orlowska K, Fling RR

1166. Spatial-temporal distribution of incidence, mortality, and case-fatality ratios of coronavirus disease 2019 and its social determinants in Brazilian municipalities.

Sci Rep

2023 Mar 13

Raymundo CE, Oliveira MC, de Araujo Eleuterio T

1167. Radical cation scavenging activity of berberine bridge enzyme-like oligosaccharide oxidases acting on short cell wall fragments.

Sci Rep

2023 Mar 13

Scortica A(#), Scafati V(#), Giovannoni M(#)

1168. Evaluating the use of large language model in identifying top research questions in gastroenterology.

Sci Rep

2023 Mar 13

Lahat A, Shachar E, Avidan B

1169. Evaluation of end-of-life vehicle recycling system in India in responding to the sustainability paradigm: an explorative study.

Sci Rep

2023 Mar 13

Molla AH, Shams H, Harun Z

1170. The predictive model for COVID-19 pandemic plastic pollution by using deep learning method.

Sci Rep

2023 Mar 13

Nanehkaran YA, Licai Z, Azarafza M

1171. Effect of thermal radiation on convective heat transfer in MHD boundary layer Carreau fluid with chemical reaction.

Sci Rep

2023 Mar 13

Shah SAGA, Hassan A, Karamti H

1172. Conductive organic electrodes for flexible electronic devices.

Sci Rep

2023 Mar 13

Chakraborty A, Herrera D, Fallen P

1173. A coupled agent-based model for France for simulating adaptation and migration decisions under future coastal flood risk.

Sci Rep

2023 Mar 13

Tierolf L, Haer T, Botzen WJW

1174. High-performance glass filters for capturing and culturing circulating tumor cells and cancer-associated fibroblasts.

Sci Rep

2023 Mar 13

Tanaka H, Iwata D, Shibata Y

1175. Predictive value of hyperglycemia on infection in critically ill patients with acute pancreatitis.

Sci Rep

2023 Mar 13

Jin Y, Tao S, Yu G

1176. Multi-arm U-Net with dense input and skip connectivity for T2 lesion segmentation in clinical trials of multiple sclerosis.

Sci Rep

2023 Mar 13

Krishnan AP, Song Z, Clayton D

1177. Exposure to hate speech deteriorates neurocognitive mechanisms of the ability to understand others' pain.

Sci Rep

2023 Mar 13

Pluta A, Mazurek J, Wojciechowski J

1178. Unfolding and modeling the recovery process after COVID lockdowns.

Sci Rep

2023 Mar 13

Yang X, Yang Y, Tan C

1179. Preparation of gypsum with high purity and whiteness from phosphogypsum for CO(2) mineral sequestration.

Sci Rep

2023 Mar 13

Zhang M, Fan X.

1180. Mangiferin relieves CCl4-induced liver fibrosis in mice.

Sci Rep

2023 Mar 13

Zhang L, Liu C, Yin L

1181. Determinants of anemia severity levels among children aged 6-59 months in Ethiopia: Multilevel Bayesian statistical approach.

Sci Rep

2023 Mar 13

Alamneh TS, Melesse AW, Gelaye KA.

Anemia is a widespread public health problem that affects all stages of life particularly preschool children and pregnant mothers. Anemia among children had significant impact on their growth, development, school performance and mortality. Different strategies like deworming of young children, vitamin A supplementation for children aged 6-59 months, and ferrous sulphate supplementation and provision of insecticide treated bed net for pregnant women were designed to control and prevent anemia. Also, previous studies on anemia factors were conducted but they were not considering the ordered nature of anemia. Therefore, this study aimed to identify the factors of anemia severity levels among children aged 6-59 months in Ethiopia by using ordinal analysis based on Bayesian hierarchical statistical approach. A secondary data analysis was conducted using the 2016 Ethiopian Demographic and Health Survey data. A total of 8483 weighted children were included. Due to the ordered nature of the anemia and nested nature of DHS data, ordinal logistic regression model based on hierarchical Bayesian statistical approach was employed to identify the determinants of anemia severity levels. In this study, moderate anemia level was found to be the commonest type which accounts around 29.4%. Female children, poorer, middle, and richest wealth index, primary maternal education and having ANC visit had lower risk of having higher order of anemia. Moderate maternal anemia and stunted children had higher chance of having higher order of anemia. Children age had significant different effect on mild and moderate anemia. Meanwhile, multiple birth/s and deworming had effect on moderate anemia. In addition, normal birth weight had also significant and different effect on mild and severe anemia and history of feverlike illness on mild anemia. The prevalence of anemia among children aged 6-59 months anemia was found to be a severe public health problem. Children age, sex, maternal education, child stunting, history of fever, multiple birth, birth weight, provision of deworming and maternal anemia was found to be the most important factors for child anemia severity levels. Therefore, intervention efforts to control and prevent anemia in Ethiopia requires targeting of these hindering factors.

1182. Fast calculation of hydrogen-bond strengths and free energy of hydration of small molecules.

Sci Rep

2023 Mar 13

Ghiandoni GM, Caldeweyher E.

1183. Systematic review of NTRK 1/2/3 fusion prevalence pan-cancer and across solid tumours.

Sci Rep

2023 Mar 13

O'Haire S, Franchini F, Kang YJ

1184. Progressive daily hopping exercise improves running economy in amateur runners: a randomized and controlled trial.

Sci Rep

2023 Mar 13

Engeroff T(#), Kalo K(#), Merrifield R

1185. Heavy metals accumulation in soil and uptake by barley (Hordeum vulgare) irrigated with contaminated water.

Sci Rep

2023 Mar 13

Haddad M, Nassar D, Shtaya M.

1186. The value evaluation model design and business innovation for P-RAN based on multi-party interaction.

Sci Rep

2023 Mar 13

Meng F, Liu H, Li W(#)

1187. Computational optimization of delivery parameters to guide the development of targeted Nasal spray.

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2023 Mar 12

Du J(#), Shao X(#), Bouteiller JC

1188. Distributed formation for interconnected networks with minimum energy restriction and interaction silence.

Sci Rep

2023 Mar 12

Qiao Y, Li J, Zhang Q

1189. Hybrid artificial electric field employing cuckoo search algorithm with refraction learning for engineering optimization problems.

Sci Rep

2023 Mar 12

Adegboye OR, Deniz Ülker E.

1190. Investigating quorum-quenching marine bacilli as potential biocontrol agents for protection of shrimps against Early Mortality Syndrome (EMS).

Sci Rep

2023 Mar 12

Müller M, Spiers AJ, Tan A

1191. Virus-free transfection, transient expression, and purification of human cardiac myosin in mammalian muscle cells for biochemical and biophysical assays.

Sci Rep

2023 Mar 12

Velayuthan LP(#), Moretto L(#), Tågerud S

1192. Effect of chemicals on the phase and viscosity behavior of water in oil emulsions.

Sci Rep

2023 Mar 12

Shafiei M, Kazemzadeh Y, Martyushev DA

Due to population growth, the need for energy, especially fossil fuels, is increased every year. Since the costs of exploring new reservoirs and drilling new wells are very high, most reservoirs have passed their first and second periods of life, and it is necessary to use EOR methods. Water-based enhanced oil recovery (EOR) methods are one of the popular methods in this field. In this method, due to the possibility of emulsion formation is high, and by creating a stable emulsion, viscosity and mobility improved. In this study, the parameters affecting the stability and viscosity of the emulsion have been investigated step by step. In the first step, 50% (v/v) of water has been selected as the best water cut. The type of salt and its best concentration was evaluated in the second step by measuring the average droplets size. The third step investigated the effect of SiO2 nanoparticles and surfactant (span80) on emulsion stability and viscosity. According to the results, the best amount of water cut was 50% due to the maximum viscosity. In salts the yield was as follows: MgCl2 > CaCl2 > MgSO4 > Na2SO4 > NaCl. The best yield was related to MgCl2 at a concentration of 10,000 ppm. Finally, it was shown that the synergy of nanoparticles and surfactants resulted in higher stability and viscosity than in the case where each was used alone. It should be noted that the optimal concentration of nanoparticles is equal to 0.1% (w/w), and the optimal concentration of surfactant is equal to 200 ppm. In general, a stable state was obtained in 50% water-cut with MgCl2 salt at a concentration of 10,000 ppm and in the presence of SiO2 nanoparticles at a concentration of 0.1% and span 80 surfactants at a concentration of 200 ppm. The results obtained from this study provide important insights for optimal selection of the water-based EOR operation parameters. Viscosity showed a similar trend with stability and droplet size. As the average particle size decreased (or stability increased), the emulsion viscosity increased.

1193. Investigation of the clinical utility of adhesion molecules in the management of thyroid nodules.

Sci Rep

2023 Mar 11

Rabi LT, Peres KC, Nascimento M

1194. Acute and chronic stress alter behavioral laterality in dogs.

Sci Rep

2023 Mar 11

Salgirli Demirbas Y, Isparta S, Saral B

1195. Mock community as an in situ positive control for amplicon sequencing of microbiotas from the same ecosystem.

Sci Rep

2023 Mar 11

Galla G, Praeg N, Colla F

1196. Serum levels of IL-4, IL-13 and IL-33 in patients with age-related macular degeneration and myeloproliferative neoplasms.

Sci Rep

2023 Mar 11

Gotfredsen K, Liisborg C, Skov V

Immune responses play a key role in the pathogenesis and progression of myeloproliferative neoplasms (MPN) and age-related macular degeneration (AMD). Recent studies suggested using MPNs as a "Human Inflammation Model" of drusen development and previous results showed interleukin-4 (IL-4) dysregulation in MPN and AMD. IL-4, IL-13 and IL-33 are all cytokines involved in the type 2 inflammatory response. This study investigated the cytokine levels of IL-4, IL-13 and IL-33 in serum of MPN and AMD patients. This cross-sectional study included 35 patients with MPN with drusen (MPNd) and 27 with MPN and normal retinas (MPNn), 28 patients with intermediate AMD (iAMD) and 29 with neovascular AMD (nAMD). With immunoassays, we quantified and compared levels of IL-4, IL-13 and IL-33 in serum between the groups. The study was conducted at Zealand University Hospital, Roskilde, Denmark, between July 2018 and November 2020. The serum levels of IL-4 were significantly higher in the MPNd group than in the MPNn group (p = 0.003). In regard to IL-33, the difference between MPNd and MPNn was not significant (p = 0.069), however, when subdivided into subgroups, a significant difference was found between polycythemia vera patients with drusen and those without drusen (p = 0.005). We found no IL-13 difference between the MPNd and MPNn groups. Our data didn't show any significant IL-4 or IL-13 serum level difference between the MPNd and iAMD groups but in regard to IL-33, data recorded a significant serum level difference between the two groups. There was no statistically significant difference between the MPNn, iAMD and nAMD groups in levels of IL-4, IL-13 and IL-33. These findings suggested that the serum levels of IL-4 and IL-33 might play a role in drusen development in MPN patients. The results might represent the type 2 inflammatory arm of the disease. The findings support the association between chronic inflammation and drusen.

1197. Mediating role of depressive symptoms on the relationship between sleep duration and cognitive function.

Sci Rep

2023 Mar 11

Wang L, He S, Yan N

1198. Characterization of phyto-components with antimicrobial traits in supercritical carbon dioxide and soxhlet Prosopis juliflora leaves extract using GC-MS.

Sci Rep

2023 Mar 11

Naik NM, Krishnaveni M, Mahadevswamy M

1199. Improving the robustness and stability of a machine learning model for breast cancer prognosis through the use of multi-modal classifiers.

Sci Rep

2023 Mar 11

Arya N, Saha S, Mathur A

Breast cancer is a deadly disease with a high mortality rate among PAN cancers. The advancements in biomedical information retrieval techniques have been beneficial in developing early prognosis and diagnosis systems for cancer patients. These systems provide the oncologist with plenty of information from several modalities to make the correct and feasible treatment plan for breast cancer patients and protect them from unnecessary therapies and their toxic side effects. The cancer patient's related information can be collected using various modalities like clinical, copy number variation, DNA-methylation, microRNA sequencing, gene expression, and histopathological whole slide images. High dimensionality and heterogeneity in these modalities demand the development of some intelligent systems to understand related features to the prognosis and diagnosis of diseases and make correct predictions. In this work, we have studied some end-to-end systems having two main components : (a) dimensionality reduction techniques applied to original features from different modalities and (b) classification techniques applied to the fusion of reduced feature vectors from different modalities for automatic predictions of breast cancer patients into two categories: short-time and long-time survivors. Principal component analysis (PCA) and variational auto-encoders (VAEs) are used as the dimensionality reduction techniques, followed by support vector machines (SVM) or random forest as the machine learning classifiers. The study utilizes raw, PCA, and VAE extracted features of the TCGA-BRCA dataset from six different modalities as input to the machine learning classifiers. We conclude this study by suggesting that adding more modalities to the classifiers provides complementary information to the classifier and increases the stability and robustness of the classifiers. In this study, the multimodal classifiers have not been validated on primary data prospectively.

1200. Dust flow analysis by low coherence Doppler lidar.

Sci Rep

2023 Mar 11

Okubo K, Lagrosas N, Shiina T.

1201. Atrial fibrillation as a new prognosis factor in chronic patients after hospitalization: the CHRONIBERIA index.

Sci Rep

2023 Mar 11

Suarez-Dono J, Novo-Veleiro I, Gude-Sampedro F

1202. Investigation the effect of different ionic liquids based-aryl imidazole on the onset precipitation of asphaltene.

Sci Rep

2023 Mar 11

El-Nagar RA, Nessim MI, Ismail DA

1203. Resilience and coping behaviour among adolescents in a high-income city-state during the COVID-19 pandemic.

Sci Rep

2023 Mar 11

Moosa AS, Ng DX, Aau WK

1204. Genetic diversity between local landraces and current breeding lines of pepper in China.

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2023 Mar 11

Guo G(#), Pan B(#), Yi X

1205. A new method assessing predicted and achieved mandibular tooth movement in adults treated with clear aligners using CBCT and individual crown superimposition.

Sci Rep

2023 Mar 11

Alwafi AA, Hannam AG, Yen EH

The purpose of this study was to demonstrate a new method for quantifying the difference between predicted and achieved tooth movement with Invisalign using stable three-dimensional (3D) mandibular landmarks and dental superimposition. Cone-beam computed tomography (CBCT) scans before (T1) and after (T2) the first series of aligners, their corresponding digital models (ClinCheck initial of the first series as T1 and ClinCheck initial of the refinement series as T2), and the ClinCheck final model of the first series as the predicted were obtained from 5 patients treated with non-extraction Invisalign therapy. After segmentation of the mandible and its dentition, T1 and T2 CBCTs were superimposed on stable anatomic structures (Pogonion and bilateral mental foramen) along with the pre-registered ClinCheck models. The 3D prediction differences between the predicted and achieved tooth position for 70 teeth with four types (incisor, canine, premolar and molar) were measured using a combination of software. The method employed in this study was tested to be reliable and repeatable with a very high intraclass correlation coefficient (ICC) for both intra- and inter-examiner reliability. Premolar Phi (rotation), Incisor Psi (mesiodistal angulation), and Molar Y (mesiodistal translation) showed a significant prediction difference (P < 0.05), which is also clinically relevant. The method involving CBCT and individual crown superimposition to measure the 3D positional changes in the mandibular dentition is a robust and novel one. While, our finding in terms of the predictability of Invisalign treatment in the mandibular dentition mainly served as a crude, cursory examination, which warrants further and more rigorous investigations. With this novel methodology, it is possible to measure any amount of 3D tooth position difference in the mandibular dentition either between the simulated and the actual or with treatment and/or growth. Deliberate use of overcorrection of which specific type of tooth movement with clear aligner treatment and to what extent, might be possible with future studies.

1206. Interannual variability in early life phenology is driven by climate and oceanic processes in two NE Atlantic flatfishes.

Sci Rep

2023 Mar 11

Vaz A(#), Primo AL, Crespo D

1207. Determination of the fate of Cholecalciferol injected by the basis of 25D3 plasma concentration.

Sci Rep

2023 Mar 11

Mousavi Rad SA, Haji Hajikolaei MR, Nouri M

Sun exposure in bovines is believed to be the most important route of 25D3 synthesis in suitable latitudes. In some situations, e.g. breeding systems, solar radiation cannot reach or penetrate into the skin and thus causes the 25D3 deficiency. Because of the critical effect of vitamin D on the immune and endocrine systems, the plasma must be enriched with 25D3 in a short period of time. In such a condition, injection of Cholecalciferol has been recommended. However, to our knowledge, the certain dose of Cholecalciferol injection for rapid 25D3 plasma enrichment has not been verified. On the other hand, it seems that the basis 25D3 concentration can influence or shift the 25D3 metabolism at the injection time. In the same line, the present study, designed to induce the different basis 25D3 concentration in treatment groups, aimed at investigating the effect of Cholecalciferol intramuscularly injection with the intermediate dose (11,000 IU/kg) on the calves' plasma 25D3 with different basis 25D3. Besides, an attempt was made to clarify the time that 25D3 reaches the sufficient concentration after injection in different treatment groups. To do this, twenty calves of 3 to 4 months old were chosen for the farm with semi-industrial elements. Furthermore, the effect of optional sun exposure/deprivation and Cholecalciferol injection on the 25D3 concentration variations was assayed. To do this, the calves were divided into four groups. Groups A and B were unconstrained to choose sun to expose or shadow in a semi-roofed place, but groups C and D were restricted to the completely dark barn. The interference of the digestive system in supplying vitamin D was minimized through dietary. All groups had a different basic concentration (25D3) on the day 21 of the experiment. At this time, groups A and C received the intermediate dose of (11,000 IU/kg) Cholecalciferol intramuscularly (IM). After Cholecalciferol injection, the effects of basis 25D3 concentration on the details of variation and fate of plasma concentration of 25D3 were investigated. The data collected from the two groups C and D showed that sun deprivation without any vitamin D supplementation, could rapidly and severely deplete the plasma from 25D3. Cholecalciferol injection could not immediately increase the 25D3 in the groups C and A. However, this injection enriches the 25D3 to sufficient value after two weeks if the basis 25D3 of plasma is insufficient, i.e. less than 30 ng/mL. Moreover, the injection of Cholecalciferol could not significantly increase the 25D3 concentration in the group A that had a sufficient basis 25D3 concentration. Therefore, it is concluded that the variation of 25D3 in plasma, after injection of Cholecalciferol, depends on its basic level at the time of injection.

1208. Uranium oxides structural transformation in human body liquids.

Sci Rep

2023 Mar 11

Poliakova T, Krot A, Trigub A

1209. Functional non-parametric mixed effects models for cytotoxicity assessment and clustering.

Sci Rep

2023 Mar 11

Ma T, Richard D, Yang YB

1210. Larval rockfish growth and survival in response to anomalous ocean conditions.

Sci Rep

2023 Mar 11

Fennie HW, Grorud-Colvert K, Sponaugle S.

1211. Comparison of methanol fixation versus cryopreservation of the placenta for metabolomics analysis.

Sci Rep

2023 Mar 11

Straughen JK, Sitarik AR, Jones AD

1212. Long-term visual outcomes in children with regressed retinopathy of prematurity.

Sci Rep

2023 Mar 11

Park SH, Ma DJ, Choi DG.

1213. Interplay between hopping dimerization and quasi-periodicity on flux-driven circular current in an incommensurate Su-Schrieffer-Heeger ring.

Sci Rep

2023 Mar 11

Roy S, Ganguly S, Maiti SK.

1214. Casson nanoliquid film flow over an unsteady moving surface with time-varying stretching velocity.

Sci Rep

2023 Mar 11

Vanitha GP, Shobha KC, Mallikarjun BP

1215. Accurate prediction by AlphaFold2 for ligand binding in a reductive dehalogenase and implications for PFAS (per- and polyfluoroalkyl substance) biodegradation.

Sci Rep

2023 Mar 11

Guo HB, Varaljay VA, Kedziora G

1216. Understanding the effect of component proportions on disease control in two-component cultivar cereal mixtures using a pathogen dispersal scaling hypothesis.

Sci Rep

2023 Mar 11

Newton AC, Skelsey P.

1217. Individualized precision targeting of dorsal attention and default mode networks with rTMS in traumatic brain injury-associated depression.

Sci Rep

2023 Mar 11

Siddiqi SH, Kandala S, Hacker CD

At the group level, antidepressant efficacy of rTMS targets is inversely related to their normative connectivity with subgenual anterior cingulate cortex (sgACC). Individualized connectivity may yield better targets, particularly in patients with neuropsychiatric disorders who may have aberrant connectivity. However, sgACC connectivity shows poor test-retest reliability at the individual level. Individualized resting-state network mapping (RSNM) can reliably map inter-individual variability in brain network organization. Thus, we sought to identify individualized RSNM-based rTMS targets that reliably target the sgACC connectivity profile. We used RSNM to identify network-based rTMS targets in 10 healthy controls and 13 individuals with traumatic brain injury-associated depression (TBI-D). These "RSNM targets" were compared with consensus structural targets and targets based on individualized anti-correlation with a group-mean-derived sgACC region ("sgACC-derived targets"). The TBI-D cohort was also randomized to receive active (n = 9) or sham (n = 4) rTMS to RSNM targets with 20 daily sessions of sequential high-frequency left-sided stimulation and low-frequency right-sided stimulation. We found that the group-mean sgACC connectivity profile was reliably estimated by individualized correlation with default mode network (DMN) and anti-correlation with dorsal attention network (DAN). Individualized RSNM targets were thus identified based on DAN anti-correlation and DMN correlation. These RSNM targets showed greater test-retest reliability than sgACC-derived targets. Counterintuitively, anti-correlation with the group-mean sgACC connectivity profile was also stronger and more reliable for RSNM-derived targets than for sgACC-derived targets. Improvement in depression after RSNM-targeted rTMS was predicted by target anti-correlation with the portions of sgACC. Active treatment also led to increased connectivity within and between the stimulation sites, the sgACC, and the DMN. Overall, these results suggest that RSNM may enable reliable individualized rTMS targeting, although further research is needed to determine whether this personalized approach can improve clinical outcomes.

1218. Increased empathic distress in adults is associated with higher levels of childhood maltreatment.

Sci Rep

2023 Mar 11

Benz ABE, Dimitroff SJ, Jeggle C

1219. Root exudate-derived compounds stimulate the phosphorus solubilizing ability of bacteria.

Sci Rep

2023 Mar 10

Pantigoso HA, Manter DK, Fonte SJ

1220. Kibble-Zurek scaling due to environment temperature quench in the transverse field Ising model.

Sci Rep

2023 Mar 10

Bácsi Á, Dóra B.

1221. Identifying polymorphic cis-regulatory variants as risk markers for lung carcinogenesis and chemotherapy responses in tobacco smokers from eastern India.

Sci Rep

2023 Mar 10

Sengupta D, Mukhopadhyay P(#), Banerjee S(#)

1222. Assessment of aerosol persistence in ICUs via low-cost sensor network and zonal models.

Sci Rep

2023 Mar 10

Glenn K, He J, Rochlin R

1223. Inactivation and spike protein denaturation of novel coronavirus variants by Cu(x)O/TiO(2) nano-photocatalysts.

Sci Rep

2023 Mar 10

Tatsuma T, Nakakido M, Ichinohe T

1224. Gene expression response of the non-target gastropod Physella acuta to Fenoxycarb, a juvenile hormone analog pesticide.

Sci Rep

2023 Mar 10

Caballero P, Prieto-Amador M, Martínez-Guitarte JL.

1225. Investigation of temperature variations on a Class-E inverter and proposing a compensation circuit to prevent harmful effects on biomedical implants.

Sci Rep

2023 Mar 10

Khodadoost M, Hayati M, Abbasi H.

1226. Image quality for visualization of cracks and fine endodontic structures using 10 CBCT devices with various scanning protocols and artefact conditions.

Sci Rep

2023 Mar 10

Pinto JC, de Faria Vasconcelos K, Leite AF

1227. Perspectives of French adolescents with ADHD and child and adolescent psychiatrists regarding methylphenidate use.

Sci Rep

2023 Mar 10

Sibeoni J, Manolios E, Hausser C

1228. Ageing in Saudi Arabia: new dimensions and intervention strategies.

Sci Rep

2023 Mar 10

Salam AA.

1229. Voxel-S-Value based 3D treatment planning methods for Y-90 microspheres radioembolization based on Tc-99m-macroaggregated albumin SPECT/CT.

Sci Rep

2023 Mar 10

Chen G, Lu Z, Jiang H

1230. Associations between ambient air pollutants and childhood hand, foot, and mouth disease in Sichuan, China: a spatiotemporal study.

Sci Rep

2023 Mar 10

Qian J(#), Luo C(#), Lv Q

1231. Efficacy of ceftazidime in a murine model following a lethal aerosol exposure to Burkholderia pseudomallei.

Sci Rep

2023 Mar 10

Pfefferle DA, Hackett M, Anderson MS

1232. Predicting wildfire ignition induced by dynamic conductor swaying under strong winds.

Sci Rep

2023 Mar 10

Wang X, Bocchini P.

1233. The effects of sexual shame, emotion regulation and gender on sexual desire.

Sci Rep

2023 Mar 10

Sævik KW, Konijnenberg C.

1234. Prediction of prognosis in patients with severe COVID-19 pneumonia using CT score by emergency physicians: a single-center retrospective study.

Sci Rep

2023 Mar 10

Oi Y, Ogawa F, Yamashiro T

1235. Gray level co-occurrence matrix and wavelet analyses reveal discrete changes in proximal tubule cell nuclei after mild acute kidney injury.

Sci Rep

2023 Mar 10

Pantic I, Cumic J, Dugalic S

1236. An innovative traffic light recognition method using vehicular ad-hoc networks.

Sci Rep

2023 Mar 10

Al-Ezaly E, M El-Bakry H, Abo-Elfetoh A

1237. A novel non-slip banded balloon catheter for endoscopic sphincteroplasty: an ex vivo and in vivo pilot study.

Sci Rep

2023 Mar 10

Inoue T, Kutsumi H, Ibusuki M

1238. Growth changes of tomato seedlings responding to sodium salt of α-naphthalene acetic acid and potassium salt of fulvic acid.

Sci Rep

2023 Mar 10

Ren M(#), Mao G(#), Zheng H

1239. Predicting the eyebrow from the orbit using three-dimensional CT imaging in the application of forensic facial reconstruction and identification.

Sci Rep

2023 Mar 10

Kim YS, Lee WJ, Yun JS

1240. Slope monitoring optimization considering three-dimensional deformation and failure characteristics using the strength reduction method: A case study.

Sci Rep

2023 Mar 10

Wang J, Li H, Jiang Y

1241. Genetic variation in salt taste receptors impact salt intake and blood pressure.

Sci Rep

2023 Mar 10

Mohammadifard N, Moazeni F, Azizian-Farsani F

1242. A diagnostic model of autoimmune hepatitis in unknown liver injury based on noninvasive clinical data.

Sci Rep

2023 Mar 10

Yang H(#), Huang L(#), Xie Y(#)

All the diagnostic criteria of autoimmune hepatitis (AIH) include histopathology. However, some patients may delay getting this examination due to concerns about the risks of liver biopsy. Therefore, we aimed to develop a predictive model of AIH diagnostic that does not require a liver biopsy. We collected demographic, blood, and liver histological data of unknown liver injury patients. First, we conducted a retrospective cohort study in two independent adult cohorts. In the training cohort (n = 127), we used logistic regression to develop a nomogram according to the Akaike information criterion. Second, we validated the model in a separate cohort (n = 125) using the receiver operating characteristic curve, decision curve analysis, and calibration plot to externally evaluate the performance of this model. We calculated the optimal cutoff value of diagnosis using Youden's index and presented the sensitivity, specificity, and accuracy to evaluate the model in the validation cohort compared with the 2008 International Autoimmune Hepatitis Group simplified scoring system. In the training cohort, we developed a model to predict the risk of AIH using four risk factors-The percentage of gamma globulin, fibrinogen, age, and AIH-related autoantibodies. In the validation cohort, the areas under the curve for the validation cohort were 0.796. The calibration plot suggested that the model had an acceptable accuracy (p > 0.05). The decision curve analysis suggested that the model had great clinical utility if the value of probability was 0.45. Based on the cutoff value, the model had a sensitivity of 68.75%, a specificity of 76.62%, and an accuracy of 73.60% in the validation cohort. While we diagnosed the validated population by using the 2008 diagnostic criteria, the sensitivity of prediction results was 77.77%, the specificity was 89.61% and the accuracy was 83.20%. Our new model can predict AIH without a liver biopsy. It is an objective, simple and reliable method that can effectively be applied in the clinic.

1243. Effect of flow change on brain injury during an experimental model of differential hypoxaemia in cardiogenic shock supported by extracorporeal membrane oxygenation.

Sci Rep

2023 Mar 10

Rozencwajg S, Heinsar S, Wildi K

1244. Correlation between patient-specific quality assurance in volumetric modulated arc therapy and 2D dose image features.

Sci Rep

2023 Mar 10

Guo Y, Hu J, Li Y

In radiotherapy, air-filled ion chamber detectors are ubiquitously used in routine dose measurements for treatment planning. However, its use has been restricted by intrinsic low spatial resolution barriers. We developed one procedure for patient-specific quality assurance (QA) in arc radiotherapy by coalescing two adjacent measurement images into a single image to improve spatial resolution and sampling frequency, and investigated how different spatial resolutions affect the QA results. PTW 729 and 1500 ion chamber detectors were used for dosimetric verification via coalescing two measurements with 5 mm-couch shift and the isocenter, and only isocenter measurement, which we call coalescence and standard acquisition (SA). Statistical process control (SPC), process capability analysis (PCA), and receiver operating characteristic (ROC) curve were used to compare the performance of the two procedures in determining tolerance levels and identifying clinically relevant errors. By analyzing 1256 γ values calculated on interpolated data points, our results indicated that detector 1500 showed higher averages in coalescence cohorts at different tolerance criteria and the dispersion degrees were spread out smaller. Detector 729 yielded a slightly lower process capability of 0.79, 0.76, 1.10, and 1.34, but detector 1500 exhibited somewhat different results of 0.94, 1.42, 1.19, and 1.60 in magnitude. The results of SPC individual control chart showed that cases in coalescence cohorts with γ values lowering its lower control limit (LCL) were greater than those in SA cohorts for detector 1500. A combination of the width of multi-leaf collimator (MLC) leaf, the cross-sectional area of the single detector, and the spacing between adjacent detectors might lead to discrepancies in percent γ values across diverse spatial resolution scenarios. The accuracy of reconstructed volume dose is mainly determined by the interpolation algorithm used in dosimetric systems. The magnitude of filling factor in the ion chamber detectors determined its ability to detect dose deviations. SPC and PCA results indicated that coalescence procedure could detect more potential failure QA results than SA while enhancing action thresholds.

1245. Euryhaline fish larvae ingest more microplastic particles in seawater than in freshwater.

Sci Rep

2023 Mar 10

Pratiwi HM, Takagi T, Rusni S

1246. Neurofilament-light chain quantification by Simoa and Ella in plasma from patients with dementia: a comparative study.

Sci Rep

2023 Mar 10

Truffi M(#), Garofalo M(#), Ricciardi A

1247. Novel long non-coding RNAs associated with inflammation and macrophage activation in human.

Sci Rep

2023 Mar 10

Chini A, Guha P, Malladi VS

1248. The systemic deletion of interleukin-1α reduces myocardial inflammation and attenuates ventricular remodeling in murine myocardial infarction.

Sci Rep

2023 Mar 10

Lugrin J, Parapanov R, Milano G

1249. Investigation of photocatalytic-proxone process performance in the degradation of toluene and ethyl benzene from polluted air.

Sci Rep

2023 Mar 10

Mehralipour J, Jonidi Jafari A, Gholami M

1250. Identification, characterization and spatiotemporal expression analysis of the FKBP family genes in Locusta migratoria.

Sci Rep

2023 Mar 10

Zhang N(#), Feng S(#), Tian Y

1251. Mohand homotopy transform scheme for the numerical solution of fractional Kundu-Eckhaus and coupled fractional Massive Thirring equations.

Sci Rep

2023 Mar 10

Luo X, Nadeem M.

1252. Prediction of the visit and occupy of the sika deer (Cervus nippon) during the summer season using a virtual ecological approach.

Sci Rep

2023 Mar 10

Osawa T, Tsutsumida N, Iijima H

1253. Numerical analysis of magnetohydrodynamics Casson nanofluid flow with activation energy, Hall current and thermal radiation.

Sci Rep

2023 Mar 10

Suresh Kumar Y, Hussain S, Raghunath K

1254. Experimental study on the effect of chlorhexidine gluconate (CG)-induced atrial fibrillation on renal water and sodium metabolism.

Sci Rep

2023 Mar 10

Li S(#), Pei H(#), Huang Y

1255. Impact of high altitude on composition and functional profiling of oral microbiome in Indian male population.

Sci Rep

2023 Mar 10

Kumari M, Bhushan B, Eslavath MR

1256. Multitask computation through dynamics in recurrent spiking neural networks.

Sci Rep

2023 Mar 10

Pugavko MM, Maslennikov OV, Nekorkin VI.

1257. Fluorouracil exacerbates alpha-crystallin B chain-mediated cell migration in triple-negative breast cancer cell lines.

Sci Rep

2023 Mar 10

Yang L, Haga Y, Nishimura A

1258. Warm, not cold temperatures contributed to a Late Miocene reef decline in the Coral Sea.

Sci Rep

2023 Mar 10

Petrick B, Reuning L, Auer G

Evidence shows that in the modern ocean, coral reefs are disappearing, and these losses are tied to climate change. However, research also shows that coral reefs can adapt rapidly to changing conditions leading some researchers to suggest that some reef systems will survive future climate change through adaptation. It is known that there were changes in the area covered by coral reefs in the past. Therefore, it is important to investigate the long-term response of coral reefs to environmental changes and high sea-surface temperatures (SSTs). However, because of diagenetic issues with SST proxies in neritic, metastable carbonate-rich environments, there is an incomplete and sometimes even incorrect understanding of how changes in SSTs affect carbonate reef systems. A good example is the Queensland Plateau offshore northeast Australia next to the threatened Great Barrier Reef. In the Late Miocene, between 11 and 7 Ma, a partial drowning caused the reef area on the Queensland Plateau to decline by ~ 50% leading to a Late Miocene change in platform geometry from a reef rimmed platform to a carbonate ramp. This reef decline was interpreted to be the result of SSTs at the lower limit of the modern reef growth window (20-18 °C). This article presents a new Late Miocene-ased SST record from the Coral Sea based on the TEX86H molecular paleothermometer, challenging this long held view. Our new record indicates warm tropical SSTs (27-32 °C) at the upper end of the modern reef growth window. We suggest that the observed temperatures potentially exceeded the optimal calcification temperatures of corals. In combination with a low aragonite supersaturation in the ocean, this could have reduced coral growth rates and ultimately lowered the aggradation potential of the reef system. These sub-optimal growth rates could have made the coral reefs more susceptible to other stressors, such as relative sea-level rise and/or changes in currents leading to reef drowning. Given that these changes affected coral reefs that were likely adapted to high temperature/low aragonite saturation conditions suggests that reefs that have adapted to non-ideal conditions may still be susceptible to future climate changes due to the interaction of multiple stressors associated with climate change.

1259. Highly reconfigurable oscillator-based Ising Machine through quasiperiodic modulation of coupling strength.

Sci Rep

2023 Mar 10

Albertsson DI, Rusu A.

1260. Development of an inhibiting antibody against equine interleukin 5 to treat insect bite hypersensitivity of horses.

Sci Rep

2023 Mar 10

Langreder N, Schäckermann D, Meier D

1261. Feasibility of patch-type wireless 12-lead electrocardiogram in laypersons.

Sci Rep

2023 Mar 10

Yoon S, Kim T, Kang E

1262. Effect of high-fat diet and morning or evening exercise on lipoprotein subfraction profiles: secondary analysis of a randomised trial.

Sci Rep

2023 Mar 10

Moholdt T, Parr EB, Devlin BL

1263. Towards a biomarker for acute arterial thrombosis using complete blood count and white blood cell differential parameters in mice.

Sci Rep

2023 Mar 10

Jang HJ, Schellingerhout D, Kim J

1264. A hybrid deep learning approach for COVID-19 detection based on genomic image processing techniques.

Sci Rep

2023 Mar 10

Hammad MS, Ghoneim VF, Mabrouk MS

1265. Sensory modality defines the relation between EEG Lempel-Ziv diversity and meaningfulness of a stimulus.

Sci Rep

2023 Mar 1

Orłowski P, Bola M.

1266. Identification and verification of feature biomarkers associated in heart failure by bioinformatics analysis.

Sci Rep

2023 Mar 1

Yu YD, Xue YT, Li Y.

1267. Incidence and predictors of cardiovascular outcomes after acute coronary syndrome in a population-based cohort study.

Sci Rep

2023 Mar 1

Ulvenstam A, Graipe A, Irewall AL

1268. Radar-based human activity recognition with adaptive thresholding towards resource constrained platforms.

Sci Rep

2023 Mar 1

Li Z, Le Kernec J, Abbasi Q

1269. Application and characterization of a novel PVDF-HFP/PVP polymer composite with MoO(3) nanowires as a protective coating for wood.

Sci Rep

2023 Mar 1

Žigon J, Centa UG, Remškar M

1270. Low profile multi-layered invisibility carpet cloak using quantum dot core-shell nanoparticles.

Sci Rep

2023 Mar 1

Esfahani AM, Yousefi L.

1271. Terahertz graphene-based multi-functional anisotropic metamaterial and its equivalent circuit model.

Sci Rep

2023 Mar 1

Asgari S, Fabritius T.

1272. The role of defense styles and psychopathological symptoms on adherence to conspiracy theories during the COVID-19 pandemic.

Sci Rep

2023 Mar 1

Gioia F, Imperato C, Boursier V

1273. Research on the synergistic modification effect and the interface mechanism of GO/SBS compound-modified asphalt based on experiments and molecular simulations.

Sci Rep

2023 Mar 1

Zeng Q, Liu Y, Liu Q

1274. Individual personality predicts social network assemblages in a colonial bird.

Sci Rep

2023 Mar 1

McCully FR, Rose PE.

1275. Effect of long-term antihypertensive treatment on cerebrovascular structure and function in hypertensive rats.

Sci Rep

2023 Mar 1

Naessens DMP, de Vos J, Richard E

1276. Fecal contamination of urban parks by domestic dogs and tragedy of the commons.

Sci Rep

2023 Mar 1

Mori K, Rock M, McCormack G

1277. Maximum dose, safety, tolerability and ketonemia after triheptanoin in glucose transporter type 1 deficiency (G1D).

Sci Rep

2023 Mar 1

Málaga I(#), Avila A(#), Primeaux S

1278. Resolving hidden pixels beyond the resolution limit of projection imaging by square aperture.

Sci Rep

2023 Mar 1

Xu KJ, Xu G.

1279. A portable, programmable, multichannel stimulator with high compliance voltage for noninvasive neural stimulation of motor and sensory nerves in humans.

Sci Rep

2023 Mar 1

Trout MA, Harrison AT, Brinton MR

1280. Top-down effect of dialogue coherence on perceived speaker identity.

Sci Rep

2023 Mar 1

Warnke L, de Ruiter JP.

1281. Damage analysis and mechanism study of sol-gel coating over KDP crystal under multi-pulse of laser irradiation at low flux.

Sci Rep

2023 Mar 1

You TH, Yang W, Hui HH

1282. Effects of the healthy lifestyle community program (cohort 1) on stress-eating and weight change after 8 weeks: a controlled study.

Sci Rep

2023 Mar 1

Anand C, Hengst K, Gellner R

Stress-eating (eating more or more unhealthily in order to accommodate to stress), contributes to the development and maintenance of obesity. The effect of comprehensive weight loss interventions on changes in stress-eating as well as the contributing role of stress-eating on weight reduction has not been examined. The impact of the 8-week intensive phase of the Healthy Lifestyle Community Programme (HLCP, cohort 1) on emotional, external and restrained eating, as expressions of stress-eating was evaluated in a non-randomized controlled trial. Intervention: 14 seminars (twice per week, including practical units), complemented by stress-regulation and cooking workshops and coaching sessions empowering participants to change their behaviour towards a healthy plant-based diet (ad libitum), stress regulation, regular exercise and to focus on social support. Participants were recruited from the general population. In the intervention group, 91 participants (IG; age: 56 ± 10, 77% female) and in the control group, 52 (CG; age: 62 ± 14, 57% female) were enrolled. At baseline, participants of the IG reported higher levels of stress (9.7 ± 5.4 points [P] vs. 7.6 ± 6.2; p < 0.011), and of emotional eating (27.9 ± 9.4 vs. 20.0 ± 7.1; p < 0.001) and external eating (29.1 ± 4.9 vs. 25.5 ± 5.6; p < 0.001) than participants of the CG. Within 8 weeks, in the IG, scores of emotional eating (- 3.5 ± 5.4 P) and external eating significantly decreased (= - 2.0 ± 3.8 P), while restrained eating increased (2.7 ± 5.0 P; p for all < 0.001). Weight change was negatively correlated with change of external eating (R2 = 0.045; CC = - 0.285; p = 0.014), indicating that a greater weight change was associated with a smaller change of external eating. This is the first study to prospectively investigate the role of stress-eating on the weight reduction effect of comprehensive lifestyle interventions. Our data confirm that overweight is associated with EE and external eating and suggest that the HLCP is capable to reduce both, weight and stress-eating.Trial registration: German Clinical Trials Register (DRKS; reference: DRKS00018821; September 18th 2019; retrospectively registered).

1283. Analysis and construction of the coal and rock cutting state identification system in coal mine intelligent mining.

Sci Rep

2023 Mar 1

Zhang M, Zhao L, Shi B.

The recognition of cutting state of coal-rock is the key technology to realize "unmanned" mining in coal face. In order to realized real-time perception and accurate judgment of coal-rock cutting state information, this paper combined the field test sampling, construction technology of complex coal seam, virtual prototype technology, bidirectional coupling technology, data processing theory, image fusion method, and deep learning theory to carry out multi domain deep fusion experimental research on multi-source heterogeneous data of coal and rock cutting state. The typical complex coal seam containing gangue, inclusion, and minor fault in Yangcun mine of Yanzhou mining area was taken as the engineering object. The high-precision three-dimensional simulation model of the complex coal seam that can update and replace particles was constructed. Based on the simulation results of Discrete Element Method-Multi Flexible Body Dynamics (DEM-MFBD), the one-dimensional original vibration acceleration signals of the key components of the shearer cutting part were determined, including spiral drum, rocker arm shell, and square head. After transforming one-dimensional original signal data into two-dimensional time-frequency images by Short-time Fourier Transform, morphological wavelet image fusion technology was used to realize the effective fusion of characteristic information of spiral drum, rocker arm shell, and square head under different working conditions. Based on the deep learning theory, the DCGAN-RFCNN (Deep Convolutional Generative Adversarial Networks-Random Forest Convolutional Neural Networks) coal and rock cutting state recognition network model was constructed. Combining convolution neural network with random forest recognition classifier, RFCNN coal and rock cutting state recognition classification model was constructed, and the recognition network model was trained to obtain the model recognition results. Through the comparative experimental analysis of the RFCNN network model with different recognition network models and different synthetic sample numbers in the recognition network, the effectiveness of the recognition network model was verified. The results show that: When synthetic samples are not included in each working condition in the RFCNN model, the average recognition rate is 90.641%. With the increase of the number of synthetic samples, the recognition rate of coal and rock cutting state increases. When the number of synthetic samples added to each working condition reaches 5000, the recognition effect is the best, and the average recognition rate reaches 98.344%, which verifies the superiority of enriching the data set by using the improved DCGAN network. Also, the RFCNN outperformed the other variants: it obtained higher recognition accuracy by 25.085, 21.925 and 19.337%, respectively, over SVW, CNN, and AlexNet. Also, the experimental platform of shearer cutting coal and rock was built, where the coal and rock cutting state recognition network was trained and tested based on the migration learning theory. Through the statistical test results, the accuracy of coal and rock cutting state recognition is 98.64%, which realizes the accurate recognition of coal and rock cutting state.

1284. An illusion of disownership over one's own limb is associated with pain perception.

Sci Rep

2023 Mar 1

Nishiyama Y, Yamashita C, Nomura S.

1285. Effect of liposomal formulation of ascorbic acid on corneal permeability.

Sci Rep

2023 Mar 1

Csorba A, Katona G, Budai-Szűcs M

1286. The effect of linagliptin on microalbuminuria in patients with diabetic nephropathy: a randomized, double blinded clinical trial.

Sci Rep

2023 Mar 1

Karimifar M, Afsar J, Amini M

1287. Subset of the periodontal ligament expressed leptin receptor contributes to part of hard tissue-forming cells.

Sci Rep

2023 Mar 1

Oka H(#), Ito S(#), Kawakami M

1288. Influence of inflow directions and setting angle of inlet guide vane on hydraulic performance of an axial-flow pump.

Sci Rep

2023 Mar 1

Nguyen DA, Ma SB, Kim S

1289. Mass flow and consumption calculations of pharmaceuticals in sewage treatment plant with emphasis on the fate and risk quotient assessment.

Sci Rep

2023 Mar 1

Badawy MI, El-Gohary FA, Abdel-Wahed MS

1290. Uncooled two-microbolometer stack for long wavelength infrared detection.

Sci Rep

2023 Mar 1

Abdullah A, Koppula A, Alkorjia O

1291. Exogenous Hemin alleviates NaCl stress by promoting photosynthesis and carbon metabolism in rice seedlings.

Sci Rep

2023 Mar 1

Meng F, Feng N, Zheng D

It is widely known that salt stress restricts rice growth and productivity severely. However, little information is available regarding the stage of rice seedlings subjected to the Heme oxygenase 1 (HO-1) inducer, Hemin. This study aimed to investigate the effects of salt stress on two rice varieties (Huanghuazhan and Xiangliangyou 900) and the effect of Hemin in promoting photosynthesis, carbohydrate metabolism, and key enzymes under salt-stress conditions. At the stage of three leaves and one heart, Huanghuazhan (HHZ) and Xiangliangyou 900 (XLY900) were sprayed with 5 μmol·L-1 Hemin and then subjected to 50 mM NaCl stress. The results showed that NaCl stress decreased the contents of chlorophyll a, chlorophyll b, and carotenoids. Furthermore, the net photosynthetic rate (Pn) decreased remarkably and the starch content was also lowered. However, NaCl treatment enhanced the concentration of sucrose and soluble sugar, simultaneously enhancing the sucrose metabolism. Nevertheless, the foliar spraying of exogenous Hemin mediated the increase in fructose and starch content, along with the activities of key enzymes' soluble acid invertase (SAInv), basic/neutral invertase (A/N-Inv), and sucrose synthase (SS) in rice leaves under NaCl stress. The sucrose phosphate synthase (SPS) in leaves decreased significantly, and the fructose accumulation in leaves increased. Hemin also mediated the increase of starch content and the α-amylase, total amylase, and starch phosphorylase (SP) activities under NaCl stress. Under stress conditions, the application of the Heme oxygenase 1 (HO-1) inhibitor, ZnPP failed to alleviate the damage to rice seedlings by NaCl stress. The ZnPP treatment showed similar tendency to the NaCl treatment on pigment content, gas exchange parameters and carbon metabolism related products and enzymes. However, ZnPP decreased carotenoids, fructose, starch content and enzyme activities related to starch metabolism. The regulation effect of Hemin on HuangHuaZhan was better than XiangLiangYou 900. These results indicate that Hemin improved the effects of salt stress on the photosynthesis and physiological characteristics of rice leaves as a result of enhanced carbohydrate metabolism. Thus, Hemin could alleviate the damage caused by salt stress to a certain extent.

1292. The interactions of monomeric acridines and unsymmetrical bisacridines (UAs) with DNA duplexes: an insight provided by NMR and MD studies.

Sci Rep

2023 Mar 1

Laskowski T, Kosno M, Andrałojć W

1293. Comparative dosimetric analysis of volumetric modulated arc therapy based craniospinal irradiation plans between Halcyon ring gantry and TrueBeam C-arm linear accelerator.

Sci Rep

2023 Mar 1

Sarkar B, Biswal SS, Shahid T

This study evaluates the volumetric modulated arc therapy (VMAT) dosimetric comparison between Halcyon ring gantry and TrueBeam c-arm linear accelerators for craniospinal irradiation (CSI) of the neuro-axis. 25 patients, who received treatment for medulloblastoma and primitive neuro-ectodermal tumors between 2018 and 2021, were planned for VMAT in True Beam (TB), and Halcyon (HAL) linear accelerators using 6 MV unflattened (FFF) photon beams (HALFFF and TBFFF). Dose-volume statistics for the target and organs at risk (OARs) and the total number of monitoring units (MUs) in the treatment plans were compared which included dose received by 95% PTV volume (V95%), volume receiving ≥ 107% dose, homogeneity index (HI), conformity index (PI), MU and dose spillage (D10%, D30%, D50%, D70%, D90%). In all 26 OARs were considered of which five were serial and the remaining were parallel structures. For the former, the dose received by 0.2 cm3, volume = D0.2 cm3) were evaluated and for the latter mean dose were evaluated. Both arms were statistically compared with paired sample t-test with a significant value of ≤ 0.05. 11 patients received treatment with the Halcyon and the rest 14 in the TrueBeam C-arm linear accelerator. Patients in the low- and intermediate-risk category (n = 13) received 23.4 Gy in 13 fractions. The remaining patients were in the high-risk category and received 35 Gy in 21 fractions or 36 Gy in 20 fractions. For HALFFF and TBFFF, PTVV95% were 97.5 ± 0.8% and 97.4 ± 0.9% respectively (p = 0.371) while the V107% were 0.6 ± 0.4% and 0.5 ± 0.5 respectively (p = 0.504). However, the number of monitoring units showed statistical significance (p < 0.001) with values of 1331.9 ± 243.4 MU and 1089 ± 206.7 MU respectively for the HAL and TB plans. The differences in spillage dose were also statistically significant, favouring HAL plans at D30% (p = 0.002), D50% (p < 0.001), D70% (p = 0.039), and D90% (p = 0.01) level except for D10% (p = 0.090). Conformity index also showed statistical significance with PI_HAL = 0.9 ± 0.02 and PI_TB = 0.89 ± 0.03 (p = 0.029). For 10 of the 21 parallel structures, the mean dose differences were statistically significant in favouring of HAL plans. Halcyon based VMAT CSI plans are dosimetrically superior in terms of organ dose, especially for the large organs, and offer lower spillage doses than the TrueBeam plans. Plans generated by both linear accelerators are suitable for the patients' treatments.

1294. Body composition and physical fitness in adults born small for gestational age at term: a prospective cohort study.

Sci Rep

2023 Mar 1

Matre M(#), Mehl CV(#), Benum SD

1295. Bacteriophage-based nano-biosensors for the fast impedimetric determination of pathogens in food samples.

Sci Rep

2023 Mar 1

Abdelhamied N, Abdelrahman F, El-Shibiny A

1296. Decreased coherence in the model of the dorsal visual pathway associated with Alzheimer's disease.

Sci Rep

2023 Mar 1

Yan S, Yang X, Yang H

1297. Sleep duration, hypnotic drug use, and risk factors: cross- sectional study.

Sci Rep

2023 Mar 1

Jalali N, Khalili P, Jamali Z

Both short sleep duration (SSD) and long sleep duration (LSD) are associated with an increased risk of morbidity and mortality. Here, we aimed to assess the prevalence of sleep duration disturbances among adults in association with demographic, medication use, personal habits, and chronic diseases, while also considering the impact of hypnotic drug use. We performed a cross-sectional study of 9991 adult participants of the Rafsanjan Cohort Study (RCS), as part of the Prospective epidemiological research studies in Iran (PERSIAN). Multivariate logistic regression analyses were conducted to assess the association between short (< 6 h) and long (> 9 h) sleep duration with demographic and lifestyle parameters and common non-communicable diseases. Additionally, we performed stratified analysis to investigate the association of sleep duration with the abovementioned factors and diseases, in groups with and without hypnotic drug use. We found higher odds of SSD significantly associated with age (P < 0.001), BMI (P < 0.001), physical activity (P < 0.001), and depression (P = 0.023). LSD displayed a positive association with the female sex (P < 0.001), opium consumption (P < 0.001), and history of MI (P = 0.045), and a reverse connection with education (P = 0.007), physical activity (P < 0.001) and alcohol consumption (P = 0.027). Stratifying for the hypnotic drug use, our sensitivity analyses indicated that in hypnotic drug users, education (P = 0.034) and physical activity (P < 0.001) were associated with LSD, in this group, significantly increased odds ratio of LSD were associated with opium consumption (P = 0.046) and thyroid dysfunction (P = 0.037). Our findings demonstrated the demographic and lifestyle factors and diseases associated with long and short sleep duration in the population of the RCS. Additionally, after stratifying for hypnotic drug use, our results indicated that some diseases are only associated with abnormal sleep duration upon using hypnotic drugs.

1298. Effects of molecular weight fraction on antioxidation capacity of rice protein hydrolysates.

Sci Rep

2023 Mar 1

Chen HJ, Dai FJ, Chen CY

1299. DNA methylation is associated with prenatal exposure to sulfur dioxide and childhood attention-deficit hyperactivity disorder symptoms.

Sci Rep

2023 Mar 1

Choi YJ(#), Cho J(#), Hong YC

1300. Potential and limitations of machine meta-learning (ensemble) methods for predicting COVID-19 mortality in a large inhospital Brazilian dataset.

Sci Rep

2023 Mar 1

de Paiva BBM, Pereira PD, de Andrade CMV

1301. Learning acquisition of consistent leader-follower relationships depends on implicit haptic interactions.

Sci Rep

2023 Mar 1

Takai A(#), Fu Q(#), Doibata Y

1302. NLRX1 knockdown attenuates pro-apoptotic signaling and cell death in pulmonary hyperoxic acute injury.

Sci Rep

2023 Mar 1

Kim HR, Kim MN, Kim EG

1303. Near-anoxia induces immobilization and sustains viability of sperm stored in ant queens.

Sci Rep

2023 Mar 1

Gotoh A, Takeshima M, Mizutani KI.

1304. Verifying the accuracy of self-reported smoking behavior in female volunteer soldiers.

Sci Rep

2023 Mar 1

Chan WH, Lai CH, Huang SJ

1305. Clinical validation of a contactless respiration rate monitor.

Sci Rep

2023 Mar 1

Bujan B, Fischer T, Dietz-Terjung S

Respiratory rate (RR) is an often underestimated and underreported vital sign with tremendous clinical value. As a predictor of cardiopulmonary arrest, chronic obstructive pulmonary disease (COPD) exacerbation or indicator of health state for example in COVID-19 patients, respiratory rate could be especially valuable in remote long-term patient monitoring, which is challenging to implement. Contactless devices for home use aim to overcome these challenges. In this study, the contactless Sleepiz One+ respiration monitor for home use during sleep was validated against the thoracic effort belt. The agreement of instantaneous breathing rate and breathing rate statistics between the Sleepiz One+ device and the thoracic effort belt was initially evaluated during a 20-min sleep window under controlled conditions (no body movement) on a cohort of 19 participants and secondly in a more natural setting (uncontrolled for body movement) during a whole night on a cohort of 139 participants. Excellent agreement was shown for instantaneous breathing rate to be within 3 breaths per minute (Brpm) compared to thoracic effort band with an accuracy of 100% and mean absolute error (MAE) of 0.39 Brpm for the setting controlled for movement, and an accuracy of 99.5% with a MAE of 0.48 Brpm for the whole night measurement, respectively. Excellent agreement was also achieved for the respiratory rate statistics over the whole night with absolute errors of 0.43, 0.39 and 0.67 Brpm for the 10th, 50th and 90th percentiles, respectively. Based on these results we conclude that the Sleepiz One+ can estimate instantaneous respiratory rate and its summary statistics at high accuracy in a clinical setting. Further studies are required to evaluate the performance in the home environment, however, it is expected that the performance is at similar level, as the measurement conditions for the Sleepiz One+ device are better at home than in a clinical setting.

1306. Maxillofacial fracture detection and classification in computed tomography images using convolutional neural network-based models.

Sci Rep

2023 Mar 1

Warin K, Limprasert W, Suebnukarn S

1307. Perpendicular magnetic anisotropy, tunneling magnetoresistance and spin-transfer torque effect in magnetic tunnel junctions with Nb layers.

Sci Rep

2023 Mar 1

Zhou B, Khanal P, Benally OJ

1308. The endometrial microbiota of women with or without a live birth within 12 months after a first failed IVF/ICSI cycle.

Sci Rep

2023 Mar 1

Bui BN, van Hoogenhuijze N, Viveen M

1309. Distribution of dietary nitrate and its metabolites in rat tissues after (15)N-labeled nitrate administration.

Sci Rep

2023 Mar 1

Park JW, Piknova B, Walter PJ

1310. The risk of second primary malignancies in colorectal cancer patients using calcium channel blockers.

Sci Rep

2023 Mar 1

Halámková J, Bohovicová L, Pehalová L

1311. A suture anchor-based repair technique for type IV jersey finger injuries: a biomechanical investigation.

Sci Rep

2023 Mar 1

Halát G, Negrin LL, Hoppe PL

1312. DFMA-oriented modular and parametric design and secondary splitting of vertical PC components.

Sci Rep

2023 Mar 1

Dong D, Zou Y, Pan H

1313. The effect of positive thinking on resilience and life satisfaction of older adults: a randomized controlled trial.

Sci Rep

2023 Mar 1

Taherkhani Z, Kaveh MH, Mani A

1314. Development and validation of nomograms predicting overall and cancer-specific survival for non-metastatic primary malignant bone tumor of spine patients.

Sci Rep

2023 Mar 1

Shao Y, Wang Z, Shi X

1315. Segmentation, tracking, and sub-cellular feature extraction in 3D time-lapse images.

Sci Rep

2023 Mar 1

Jiang J, Khan A, Shailja S

1316. Different correlation of body mass index with body fatness and obesity-related biomarker according to age, sex and race-ethnicity.

Sci Rep

2023 Mar 1

Jeong SM, Lee DH, Rezende LFM

The relationship between body mass index (BMI) and body fatness could differ according to age, sex, and race-ethnicity. We aimed to evaluate in which contexts BMI could be a good measure for body fatness compared to dual-energy X-ray absorptiometry (DXA) derived measures. The study population included 18,061 participants (9141 men and 8920 women) aged 18 and older who tested DXA from the National Health and Nutrition Examination Survey (NHANES) database from 1999 to 2006, and 8107 men and 10,754 women with DXA data from Korea NHANES from 2008 to 2011 to represent the Asian population. We calculated Pearson correlation coefficients between BMI and DXA derived fat mass index (FMI) and percentage body fat (PBF) depending on age, sex, and race-ethnicity. The correlation between BMI, FMI and PBF and obesity-related biomarkers was also estimated among the subgroup with both DXA and information on each biomarker. BMI was strongly correlated with FMI (r = 0.944 in men and 0.976 in women), PBF (r = 0.735 in men and 0.799 in women), and truncal fat mass (r = 0.914 in men and 0.941 in women) with correlations stronger in women than in men except for with waist-height ratio (r = 0.921 in men and 0.911 in women). The correlation between BMI and DXA derived adiposity weakened with age in both sexes. BMI was less correlated with FMI (r = 0.840 in men and 0.912 in women), PBF (r = 0.645 in men and 0.681 in women), and truncal fat mass (r = 0.836 in men and 0.884 in women) in Korean compared to other race-ethnicities. Among obesity-related biomarkers, insulin was the most strongly correlated to body adiposity indices in both sexes and strength of these correlations generally decreased with age. BMI predicted obesity-related biomarkers as well as FMI and truncal fat mass and superior to PBF. BMI could be a good measure for body fatness, particularly among young age groups, women, the US population, but less so in Korean populations. The lower correlation between BMI and body fatness in older compared to younger age groups could be related to increasing PBF and decreasing lean body mass.

1317. Multiple solutions for non-linear radiative mixed convective hybrid nanofluid flow over an exponentially shrinking surface.

Sci Rep

2023 Mar 1

Sarfraz M, Yasir M, Khan M.

1318. Training-induced impairment of endothelial function in track and field female athletes.

Sci Rep

2023 Mar 1

Grandys M, Majerczak J, Frolow M

1319. Age and sex differences in the effectiveness of intradialytic resistance training on muscle function.

Sci Rep

2023 Mar 1

Zelko A(#), Rosenberger J(#), Kolarcik P(#)