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Sci Rep

2023 Jun 9

Liu D, Li L.

2. Social-pair judgment bias testing in slow-growing broiler chickens raised in low- or high-complexity environments.

Sci Rep

2023 Jun 9

Lourenço-Silva MI, Ulans A, Campbell AM

3. MATLAB simulation based study on poliovirus sensing through one-dimensional photonic crystal with defect.

Sci Rep

2023 Jun 9

Aly AH, Mohamed BA, Awasthi SK

4. Gravity-driven controls on fluid and carbonate precipitation distributions in fractures.

Sci Rep

2023 Jun 9

Xu Z(#), Cao H(#), Yoon S

5. Heat source modeling, penetration analysis and parametric optimization of super spray MAG welding.

Sci Rep

2023 Jun 9

Li Z, Xia Y.

6. Exogenously delivered iPSCs disrupt the natural repair response of endogenous MPCs after bone injury.

Sci Rep

2023 Jun 9

Ferrie L, Premnath P, Olsen A

Promoting bone healing including fracture non-unions are promising targets for bone tissue engineering due to the limited success of current clinical treatment methods. There has been significant research on the use of stem cells with and without biomaterial scaffolds to treat bone fractures due to their promising regenerative capabilities. However, the relative roles of exogenous vs. endogenous stem cells and their overall contribution to in vivo fracture repair is not well understood. The purpose of this study was to determine the interaction between exogenous and endogenous stem cells during bone healing. This study was conducted using a standardized burr-hole bone injury model in a mesenchymal progenitor cell (MPC) lineage-tracing mouse under normal homeostatic and osteoporotic conditions. Burr-hole injuries were treated with a collagen-I biomaterial loaded with and without labelled induced pluripotent stem cells (iPSCs). Using lineage-tracing, the roles of exogenous and endogenous stem cells during bone healing were examined. It was observed that treatment with iPSCs resulted in muted healing compared to untreated controls in intact mice post-injury. When the cell populations were examined histologically, iPSC-treated burr-hole defects presented with a dramatic reduction in endogenous MPCs and cell proliferation throughout the injury site. However, when the ovaries were removed and an osteoporotic-like phenotype induced in the mice, iPSCs treatment resulted in increased bone formation relative to untreated controls. In the absence of iPSCs, endogenous MPCs demonstrated robust proliferative and osteogenic capacity to undertake repair and this behaviour was disrupted in the presence of iPSCs which instead took on an osteoblast fate but with little proliferation. This study clearly demonstrates that exogenously delivered cell populations can impact the normal function of endogenous stem/progenitor populations during the normal healing cascade. These interactions need to be better understood to inform cell and biomaterial therapies to treat fractures.

7. A simulation study on missing data imputation for dichotomous variables using statistical and machine learning methods.

Sci Rep

2023 Jun 9

Ge Y(#), Li Z(#), Zhang J.

8. Asymptomatic viral infection is associated with lower host reproductive output in wild mink populations.

Sci Rep

2023 Jun 9

Zalewski A, Virtanen JME, Zalewska H

9. Re-irradiation combined with bevacizumab for recurrent glioblastoma beyond bevacizumab failure: survival outcomes and prognostic factors.

Sci Rep

2023 Jun 9

You WC(#), Lee HD, Pan HC(#)

The combination of re-irradiation and bevacizumab has emerged as a potential therapeutic strategy for patients experiencing their first glioblastoma multiforme (GBM) recurrence. This study aims to assess the effectiveness of the re-irradiation and bevacizumab combination in treating second-progression GBM patients who are resistant to bevacizumab monotherapy. This retrospective study enrolled 64 patients who developed a second progression after single-agent bevacizumab therapy. The patients were divided into two groups: 35 underwent best supportive care (none-ReRT group), and 29 received bevacizumab and re-irradiation (ReRT group). The study measured the overall survival time after bevacizumab failure (OST-BF) and re-irradiation (OST-RT). Statistical tests were used to compare categorical variables, evaluate the difference in recurrence patterns between the two groups, and identify optimal cutoff points for re-irradiation volume. The results of the Kaplan-Meier survival analysis indicated that the re-irradiation (ReRT) group experienced a significantly higher survival rate and longer median survival time than the non-ReRT group. The median OST-BF and OST-RT were 14.5 months and 8.8 months, respectively, for the ReRT group, while the OST-BF for the none-ReRT group was 3.9 months (p < 0.001). The multivariable analysis identified the re-irradiation target volume as a significant factor for OST-RT. Moreover, the re-irradiation target volume exhibited excellent discriminatory ability in the area under the curve (AUC) analysis, with an optimal cutoff point of greater than 27.58 ml. These findings suggest that incorporating re-irradiation with bevacizumab therapy may be a promising treatment strategy for patients with recurrent GBM resistant to bevacizumab monotherapy. The re-irradiation target volume may serve as a valuable selection factor in determining which patients with recurrent GBM are likely to benefit from the combined re-irradiation and bevacizumab treatment modality.

10. A downscaling and bias correction method for climate model ensemble simulations of local-scale hourly precipitation.

Sci Rep

2023 Jun 9

Yoshikane T, Yoshimura K.

11. The Caenorhabditis elegans Shugoshin regulates TAC-1 in cilia.

Sci Rep

2023 Jun 9

Reed R(#), Park K(#), Waddell B

12. Novel nomogram for predicting pulmonary complications in patients with blunt chest trauma with rib fractures: a retrospective cohort study.

Sci Rep

2023 Jun 9

Seok J, Yoon SY, Lee JY

13. A novel HCP (heparin-binding protein-C reactive protein-procalcitonin) inflammatory composite model can predict severe acute pancreatitis.

Sci Rep

2023 Jun 9

Kong D, Lei Z, Wang Z

Severe acute pancreatitis (SAP) presents with an aggressive clinical presentation and high lethality rate. Early prediction of the severity of acute pancreatitis will help physicians to further precise treatment and improve intervention. This study aims to construct a composite model that can predict SAP using inflammatory markers. 212 patients with acute pancreatitis enrolled from January 2018 to June 2020 were included in this study, basic parameters at admission and 24 h after hospitalization, and laboratory results such as inflammatory markers were collected. Pearson's test was used to analyze the correlation between heparin-binding protein (HBP), procalcitonin (PCT), and C-reactive protein (CRP). Risk factors affecting SAP were analyzed using multivariate logistic regression, inflammatory marker models were constructed, and subject operating curves were used to verify the discrimination of individual as well as inflammatory marker models and to find the optimal cut-off value based on the maximum Youden index. In the SAP group, the plasma levels of HBP, CRP, and PCT were 139.1 ± 74.8 ng/mL, 190.7 ± 106.3 mg/L and 46.3 ± 22.3 ng/mL, and 25.3 ± 16.0 ng/mL, 145.4 ± 67.9 mg/L and 27.9 ± 22.4 ng/mL in non-SAP patients, with a statistically significant difference between the two groups (P < 0.001), The Pearson correlation analysis showed a positive correlation between the three values of HBP, CRP, and PCT. The results of the multivariate logistic regression analysis showed that HBP (OR = 1.070 [1.044-1.098], P < 0.001), CRP (OR = 1.010 [1.004-1.016], P = 0.001), and PCT (OR = 1.030[1.007-1.053], P < 0.001) were risk factors for SAP, and the area under the curve of the HBP-CRP-PCT model was 0.963 (0.936-0.990). The HCP model, consisting of HBP, CRP, and PCT; is well differentiated and easy to use and can predict the risk of SAP in advance.

14. Predictive value of PET metabolic parameters for occult lymph node metastases in PET/CT defined node-negative patients with advanced epithelial ovarian cancer.

Sci Rep

2023 Jun 9

Xue B, Wang X.

15. Oily fish and raw vegetable consumption can decrease the risk of AQP4-positive neuromyelitis optica spectrum disorders: a Mendelian-randomization study.

Sci Rep

2023 Jun 9

Wang S, Pan L, Wu R(#)

16. Threshold magnetic field as a universal criterion for the selective transport of magnetized particles in microdroplets.

Sci Rep

2023 Jun 9

Bono S, Konishi S.

17. The accuracy of non-contrast brain CT scan in predicting the presence of a vascular etiology in patients with primary intracranial hemorrhage.

Sci Rep

2023 Jun 9

Abbasi B, Ganjali R, Akhavan R

18. Reference distributions of aortic calcification and association with Framingham risk score.

Sci Rep

2023 Jun 9

Horbal SR, Derstine BA(#), Brown E(#)

19. The evolutionary history of Brachyury genes in Hydrozoa involves duplications, divergence, and neofunctionalization.

Sci Rep

2023 Jun 9

Vetrova AA, Kupaeva DM, Kizenko A

20. A randomized controlled trial for comparing efficacy and safety between intraarticular polynucleotide and hyaluronic acid for knee osteoarthritis treatment.

Sci Rep

2023 Jun 9

Kim TW, Chang MJ, Shin CY

21. Learning to cooperate for low-Reynolds-number swimming: a model problem for gait coordination.

Sci Rep

2023 Jun 9

Liu Y, Zou Z, Pak OS

22. Application of self-supervised approaches to the classification of X-ray diffraction spectra during phase transitions.

Sci Rep

2023 Jun 9

Sun Y, Brockhauser S, Hegedűs P

23. Gene expression in bumble bee larvae differs qualitatively between high and low concentration imidacloprid exposure levels.

Sci Rep

2023 Jun 9

Martín-Blázquez R, Calhoun AC, Sadd BM

24. Multiple mitogenomes indicate Things Fall Apart with Out of Africa or Asia hypotheses for the phylogeographic evolution of Honey Bees (Apis mellifera).

Sci Rep

2023 Jun 9

Carr SM.

25. Earth-vertical motion perception assessment using an elevator: a feasibility study.

Sci Rep

2023 Jun 9

Schellenberg S, Straumann D, Green DA

26. Lifelong nnU-Net: a framework for standardized medical continual learning.

Sci Rep

2023 Jun 9

González C, Ranem A, Pinto Dos Santos D

27. Soliton solution, breather solution and rational wave solution for a generalized nonlinear Schrödinger equation with Darboux transformation.

Sci Rep

2023 Jun 9

Fan C, Li L, Yu F.

28. Smoothing method for unit quaternion time series in a classification problem: an application to motion data.

Sci Rep

2023 Jun 9

Ballante E, Bellanger L, Drouin P

29. Tryptophan-like side chain holding aptamers inhibit respiratory syncytial virus infection of lung epithelial cells.

Sci Rep

2023 Jun 9

Percze K, Tolnai ZJ, Eleveld M

30. The effect of an interactive weekly text-messaging intervention on retention in prevention of mother-to-child transmission of HIV care: a randomised controlled trial (WelTel PMTCT).

Sci Rep

2023 Jun 9

Nordberg B(#), van der Kop ML(#), Mwangi W

Retention in prevention of mother-to-child transmission (PMTCT) care is critical to prevent vertical HIV transmission and reduce morbidity and mortality of mother-infant pairs. We investigated whether weekly, interactive text-messaging improved 18-month postpartum retention in PMTCT care. This randomised, two-armed, parallel trial was conducted at six PMTCT clinics in western Kenya. Pregnant women with HIV at least 18 years of age with access to a mobile phone, able to text-message, or had somebody who could text on their behalf, were eligible. Participants were randomly assigned at a 1:1 ratio in block sizes of four to the intervention or control group. The intervention group received weekly text messages asking "How are you?" ("Mambo?" in Swahili) and were requested to respond within 48 h. Healthcare workers called women who indicated a problem or did not respond. The intervention was administered up to 24 months after delivery. Both groups received standard care. The primary outcome was retention in care at 18 months postpartum (i.e., clinic attendance 16-24 months after delivery based on data from patient files, patient registers and Kenya's National AIDS and STI Control Programme database), which was analysed by intention-to-treat. Researchers and data collectors were masked to group assignment, while healthcare workers were not. Between June 25th, 2015, and July 5th, 2016, we randomly assigned 299 women to the intervention and 301 to standard care only. Follow-up concluded on July 26th, 2019. The proportion of women retained in PMTCT care at 18 months postpartum was not significantly different between the intervention (n = 210/299) and control groups (n = 207/301) (risk ratio 1.02, 95% confidence interval 0.92-1.14, p = 0.697). No adverse events related to the mobile phone intervention were reported. Weekly, interactive text-messaging was not associated with improved retention in PMTCT care at 18 months postpartum or linkage to care up to 30 months postpartum in this setting. (ISRCTN No. 98818734).

31. Detailed analysis of an enriched deep intronic ABCA4 variant in Irish Stargardt disease patients.

Sci Rep

2023 Jun 9

Whelan L, Dockery A, Stephenson KAJ

32. A memristor fingerprinting and characterisation methodology for hardware security.

Sci Rep

2023 Jun 9

Aitchison C, Halak B, Serb A

33. Topical timolol maleate 0.5% after fractional carbon dioxide laser versus fractional carbon dioxide laser alone in treatment of acne scars: split face comparative study.

Sci Rep

2023 Jun 9

Hawwas ARM, Mohamed HAK, Sayedahmed OME

34. Spin-orbit torque flash analog-to-digital converter.

Sci Rep

2023 Jun 9

Ghanatian H, Benetti L, Anacleto P

35. The interaction of Schistosoma mansoni infection with diabetes mellitus and obesity in mice.

Sci Rep

2023 Jun 9

Amer AS, Othman AA, Dawood LM

Human schistosomiasis is one of the most prevalent parasitic diseases worldwide. Various host factors can affect the host-parasite interactions. Therefore, the aim of the present work was to determine the parasitological, histopathological, biochemical, and immunological status of Schistosoma mansoni-infected hosts with metabolic disorders to identify the underlying possible mechanisms of these comorbidities. The study animals were divided into four groups. Group I represented the control groups, namely, the normal control group, the S. mansoni-infected control group, and the noninfected type 1 diabetes (T1DM), type 2 diabetes (T2DM), and obesity groups. The mice of the other three groups underwent induction of T1DM (Group II), T2DM (Group III) and obesity (Group IV) before being infected with S. mansoni. All mice were subjected to body weight measurement, blood glucose and insulin assessment, parasitological evaluation of adult worm count, tissue egg count and intestinal oogram. Histopathological and immunohistochemical study using anti-glial fibrillary acidic protein (GFAP) in hepatic stellate cells (HSCs) and image analysis of Masson's trichrome-stained liver sections using ImageJ (Fiji) software were carried out. Additionally, immunological analysis of tumour necrosis factor (TNF) beta, interleukin-5 (IL-5), IL-10, Forkhead box P3 (FOXP3) and pentraxin 3 (PTX3) levels besides biochemical study of total lipid profile were evaluated. The present study revealed a significant increase in the adult worm count and tissue egg output in the obesity group compared to the infected control group. The oogram of counted eggs showed prevalence of immature eggs in T1DM group, while T2DM and obese groups showed prevalence of mature eggs. The fibrosis area percentage showed significant increase in T2DM and obese groups while it was decreased in T1DM group in comparison to infected control group. Our data also showed significant increase in the levels of TNF-β, IL-5, PTX3 in T1DM, T2DM and obesity groups in comparison to infected control group, whilst the levels of FOXP3 and IL-10 were increased in the infected groups in comparison to their noninfected controls. Moreover, infected T1DM, T2DM and obesity groups showed higher blood glucose and lipid profile in comparison to the infected control group. However, these parameters were improved in comparison to their noninfected controls. In sum, induction of T2DM and obesity increased tissue egg counts, mature egg percentage, and fibrosis density, while schistosome infection induced changes in the lipid profile and blood glucose levels in infected diabetic and obese groups and impacted favorably insulin levels in obese mice. By better understanding the complexities of host-parasite interactions, efforts to reduce the burden of these debilitating diseases can be improved.

36. Epidemiology of rhegmatogenous retinal detachment in commercially insured myopes in the United States.

Sci Rep

2023 Jun 9

Ludwig CA, Vail D, Al-Moujahed A

37. Allopurinol non-covalently facilitates binding of unconventional peptides to HLA-B*58:01.

Sci Rep

2023 Jun 9

Huan X, Zhuo N, Lee HY

38. Blood viscosity associated with stroke mechanism and early neurological deterioration in middle cerebral artery atherosclerosis.

Sci Rep

2023 Jun 9

Woo HG, Kim HG, Lee KM

39. The spatio-temporal architecture of everyday manual behavior.

Sci Rep

2023 Jun 9

Sili D, De Giorgi C, Pizzuti A

40. RNA binding by the glucocorticoid receptor attenuates dexamethasone-induced gene activation.

Sci Rep

2023 Jun 9

Lammer NC, Ashraf HM, Ugay DA

41. Stacked SiGe nanosheets p-FET for Sub-3 nm logic applications.

Sci Rep

2023 Jun 9

Chu CL, Hsu SH, Chang WY

42. Improved on-treatment fibrosis-4 during antiviral therapy and lower hepatocellular carcinoma risk in cirrhotic patients with hepatitis B.

Sci Rep

2023 Jun 9

Oh JH, Park Y, Goh MJ

43. Multitemporal modeling and simulation of the complex dynamics in urban wetlands: the case of Bogota, Colombia.

Sci Rep

2023 Jun 9

Cuellar Y, Perez L.

44. Relation of sedentary behaviour to physical function in phase I cardiac rehabilitation.

Sci Rep

2023 Jun 9

Izawa KP(#), Kanejima Y(#), Kitamura M

45. Effects of an aerobic training program on liver functions in male athletes: a randomized controlled trial.

Sci Rep

2023 Jun 9

Bari MA, MahmoodAlobaidi MA, Ansari HA

46. Recovery of pinch force sense after short-term fatigue.

Sci Rep

2023 Jun 9

Li L, Li YX, Zhang CL

47. Surface modification of polycaprolactone nanofibers through hydrolysis and aminolysis: a comparative study on structural characteristics, mechanical properties, and cellular performance.

Sci Rep

2023 Jun 9

Yaseri R, Fadaie M, Mirzaei E

Hydrolysis and aminolysis are two main commonly used chemical methods for surface modification of hydrophobic tissue engineering scaffolds. The type of chemical reagents along with the concentration and treatment time are main factors that determine the effects of these methods on biomaterials. In the present study, electrospun poly (ℇ-caprolactone) (PCL) nanofibers were modified through hydrolysis and aminolysis. The applied chemical solutions for hydrolysis and aminolysis were NaOH (0.5-2 M) and hexamethylenediamine/isopropanol (HMD/IPA, 0.5-2 M) correspondingly. Three distinct incubation time points were predetermined for the hydrolysis and aminolysis treatments. According to the scanning electron microscopy results, morphological changes emerged only in the higher concentrations of hydrolysis solution (1 M and 2 M) and prolonged treatment duration (6 and 12 h). In contrast, aminolysis treatments induced slight changes in the morphological features of the electrospun PCL nanofibers. Even though surface hydrophilicity of PCL nanofibers was noticeably improved through the both methods, the resultant influence of hydrolysis was comparatively more considerable. As a general trend, both hydrolysis and aminolysis resulted in a moderate decline in the mechanical performance of PCL samples. Energy dispersive spectroscopy analysis indicated elemental changes after the hydrolysis and aminolysis treatments. However, X-ray diffraction, thermogravimetric analysis, and infrared spectroscopy results did not show noticeable alterations subsequent to the treatments. The fibroblast cells were well spread and exhibited a spindle-like shape on the both treated groups. Furthermore, according to the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay, the surface treatment procedures ameliorated proliferative properties of PCL nanofibers. These findings represented that the modified PCL nanofibrous samples by hydrolysis and aminolysis treatments can be considered as the potentially favorable candidates for tissue engineering applications.

48. Bone aerophones from Eynan-Mallaha (Israel) indicate imitation of raptor calls by the last hunter-gatherers in the Levant.

Sci Rep

2023 Jun 9

Davin L(#), Tejero JM(#), Simmons T

49. A perfusion-based three-dimensional cell culture system to model alveolar rhabdomyosarcoma pathological features.

Sci Rep

2023 Jun 9

Saggioro M(#), D'Agostino S(#), Veltri G

50. An end-to-end convolutional neural network for automated failure localisation and characterisation of 3D interconnects.

Sci Rep

2023 Jun 9

Paulachan P, Siegert J, Wiesler I

51. Fibroblasts are not just fibroblasts: clear differences between dermal and pulmonary fibroblasts' response to fibrotic growth factors.

Sci Rep

2023 Jun 9

Madsen SF, Sand JMB, Juhl P

52. GLP‑1 receptor agonist protects palmitate-induced insulin resistance in skeletal muscle cells by up-regulating sestrin2 to promote autophagy.

Sci Rep

2023 Jun 9

Tian X, Gao Y, Kong M

53. Host-adaptive traits in the plant-colonizing Pseudomonas donghuensis P482 revealed by transcriptomic responses to exudates of tomato and maize.

Sci Rep

2023 Jun 9

Krzyżanowska DM, Jabłońska M, Kaczyński Z

54. Ab initio calculation for electronic structure and optical property of tungsten carbide in a TiCN-based cermet for solar thermal applications.

Sci Rep

2023 Jun 9

Hayakawa S, Chono T(#), Watanabe K(#)

55. Biophysical models resolution affects coral connectivity estimates.

Sci Rep

2023 Jun 9

Saint-Amand A, Lambrechts J, Hanert E.

56. A safe and effective micro-choice based rehabilitation for patients with long COVID: results from a quasi-experimental study.

Sci Rep

2023 Jun 9

Frisk B(#), Jürgensen M(#), Espehaug B

57. Effect of the 2020 hypersensitivity pneumonitis guideline on the pathologic diagnosis of interstitial pneumonia.

Sci Rep

2023 Jun 8

Ozasa M, Bychkov A, Zaizen Y

58. Regulation of TRIB1 abundance in hepatocyte models in response to proteasome inhibition.

Sci Rep

2023 Jun 8

Soubeyrand S, Lau P, McPherson R.

59. MER and increased operative time are not risk factors for the formation of pneumocephalus during DBS.

Sci Rep

2023 Jun 8

Iess G(#), Bonomo G(#), Levi V

Although only recently directional leads have proven their potential to compensate for sub-optimally placed electrodes, optimal lead positioning remains the most critical factor in determining Deep Brain Stimulation (DBS) outcome. Pneumocephalus is a recognized source of error, but the factors that contribute to its formation are still a matter of debate. Among these, operative time is one of the most controversial. Because cases of DBS performed with Microelectrode Recordings (MER) are affected by an increase in surgical length, it is useful to analyze whether MER places patients at risk for increased intracranial air entry. Data of 94 patients from two different institutes who underwent DBS for different neurologic and psychiatric conditions were analyzed for the presence of postoperative pneumocephalus. Operative time and use of MER, as well as other potential risk factors for pneumocephalus (age, awake vs. asleep surgery, number of MER passages, burr hole size, target and unilateral vs. bilateral implants) were examined. Mann-Whitney U and Kruskal-Wallis tests were utilized to compare intracranial air distributions across groups of categorical variables. Partial correlations were used to assess the association between time and volume. A generalized linear model was created to predict the effects of time and MER on the volume of intracranial air, controlling for other potential risk factors identified: age, number of MER passages, awake vs. asleep surgery, burr hole size, target, unilateral vs. bilateral surgery. Significantly different distributions of air volume were noted between different targets, unilateral vs. bilateral implants, and number of MER trajectories. Patients undergoing DBS with MER did not present a significant increase in pneumocephalus compared to patients operated without (p = 0.067). No significant correlation was found between pneumocephalus and time. Using multivariate analysis, unilateral implants exhibited lower volumes of pneumocephalus (p = 0.002). Two specific targets exhibited significantly different volumes of pneumocephalus: the bed nucleus of the stria terminalis with lower volumes (p < 0.001) and the posterior hypothalamus with higher volumes (p = 0.011). MER, time, and other parameters analyzed failed to reach statistical significance. Operative time and use of intraoperative MER are not significant predictors of pneumocephalus during DBS. Air entry is greater for bilateral surgeries and may be also influenced by the specific stimulated target.

60. Comparison and fusion prediction model for lung adenocarcinoma with micropapillary and solid pattern using clinicoradiographic, radiomics and deep learning features.

Sci Rep

2023 Jun 8

Wang F(#), Wang CL(#), Yi YQ

61. SelSA-1, a novel HDAC inhibitor demonstrates enhanced chemotherapeutic potential by redox modulation.

Sci Rep

2023 Jun 8

Garg A, Desai D, Bhalla A

62. Impacts of spaceflight experience on human brain structure.

Sci Rep

2023 Jun 8

McGregor HR, Hupfeld KE, Pasternak O

63. A pilot study investigating affective forecasting biases with a novel virtual reality-based paradigm.

Sci Rep

2023 Jun 8

Loisel-Fleuriot L, Fovet T, Bugnet A

64. Vortex dynamics in NbTi films at high frequency and high DC magnetic fields.

Sci Rep

2023 Jun 8

Ghigo G(#), Torsello D(#), Gozzelino L

65. Primary mouse myoblast metabotropic purinoceptor profiles and calcium signalling differ with their muscle origin and are altered in mdx dystrophinopathy.

Sci Rep

2023 Jun 8

Róg J, Oksiejuk A, Górecki DC

66. Evolution of NLR genes in genus Arachis reveals asymmetric expansion of NLRome in wild and domesticated tetraploid species.

Sci Rep

2023 Jun 8

Rizwan M, Haider SZ, Bakar A

Arachis hypogaea is an allotetraploid crop widely grown in the world. Wild relatives of genus Arachis are the rich source of genetic diversity and high levels of resistance to combat pathogens and climate change. The accurate identification and characterization of plant resistance gene, nucleotide binding site leucine rich repeat receptor (NLRs) substantially contribute to the repertoire of resistances and improve production. In the current study, we have studied the evolution of NLR genes in genus Arachis and performed their comparative genomics among four diploids (A. duranensis, A. ipaensis, A. cardenasii, A. stenosperma) and two tetraploid (wild: A. monticola and domesticated: A. hypogaea) species. In total 521, 354, 284, 794, 654, 290 NLR genes were identified from A. cardenasii, A. stenosperma and A. duranensis, A. hypogaea, A. monticola and A. ipaensis respectively. Phylogenetic analysis and classification of NLRs revealed that they belong to 7 subgroups and specific subgroups have expanded in each genome leading towards divergent evolution. Gene gain and loss, duplication assay reveals that wild and domesticated tetraploids species have shown asymmetric expansion of NLRome in both sub-genome (AA and BB). A-subgenome of A. monticola exhibited significant contraction of NLRome while B-subgenome shows expansion and vice versa in case of A. hypogaea probably due to distinct natural and artificial selection pressure. In addition, diploid species A. cardenasii revealed the largest repertoire of NLR genes due to higher frequency of gene duplication and selection pressure. A. cardenasii and A. monticola can be regarded as putative resistance resources for peanut breeding program for introgression of novel resistance genes. Findings of this study also emphasize the application neo-diploids and polyploids due to higher quantitative expression of NLR genes. To the best of our knowledge, this is the first study that studied the effect of domestication and polyploidy on the evolution of NLR genes in genus Arachis to identify genomic resources for improving resistance of polyploid crop with global importance on economy and food security.

67. Fast 3D gravity and magnetic modelling using midpoint quadrature and 2D FFT.

Sci Rep

2023 Jun 8

Wang X, Liu J, Li J

68. High expression of GPR176 predicts poor prognosis of gastric cancer patients and promotes the proliferation, migration, and invasion of gastric cancer cells.

Sci Rep

2023 Jun 8

Zhang Y(#), Gu X(#), Zhu F

69. HighAltitudeOmicsDB, an integrated resource for high-altitude associated genes and proteins, networks and semantic-similarities.

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2023 Jun 8

Gupta A, Pathak S, Varshney R

70. RNA activation in ticks.

Sci Rep

2023 Jun 8

Kwofie KD, Hernandez EP, Anisuzzaman

71. Foot morphology as a predictor of hallux valgus development in children.

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2023 Jun 8

Martín-Casado L, Aldana-Caballero A, Barquín C

72. Bioinformatics and system biology approach to identify potential common pathogenesis for COVID-19 infection and osteoarthritis.

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2023 Jun 8

Chen Z, Wang W, Jue H

73. A single-cell RNA-seq analysis unravels the heterogeneity of primary cultured human corneal endothelial cells.

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2023 Jun 8

Català P(#), Groen N(#), LaPointe VLS

74. Climate analogs can catalyze cross-regional dialogs for US specialty crop adaptation.

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2023 Jun 8

Chaudhary S, Rajagopalan K, Kruger CE

75. Early-life adversities and later-life reproductive patterns in women with fully traced reproductive history.

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2023 Jun 8

Klimek M, Entringer S, Matras A

76. The influences of daily experiences of awe on stress, somatic health, and well-being: a longitudinal study during COVID-19.

Sci Rep

2023 Jun 8

Monroy M, Uğurlu Ö, Zerwas F

77. An improved preparation method for a CuO/CeO(2)-coated monolith for the CO-PrOx reaction.

Sci Rep

2023 Jun 8

Meißner J, Ahrens L, Pasel J

78. Machine learning reveals sex-specific associations between cardiovascular risk factors and incident atherosclerotic cardiovascular disease.

Sci Rep

2023 Jun 8

Kwak S, Lee HJ(#), Kim S(#)

79. Retreatment of oval-shaped root canals filled with TotalFill bioceramic or AH plus sealer.

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2023 Jun 8

Jamleh A, Nassar M, Alfadley A

80. Acute effects of transcranial direct current stimulation (tDCS) on peak torque and 5000 m running performance: a randomized controlled trial.

Sci Rep

2023 Jun 8

Dos Santos LF, Dos Santos Silva D, de Jesus Alves MD

81. Climatic niche convergence through space and time for a potential archaeophyte (Acacia caven) in South America.

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2023 Jun 8

Velasco N, Andrade N, Smit C

82. Ultra-effective modified clinoptilolite adsorbent for selective thorium removal from radioactive residue.

Sci Rep

2023 Jun 8

Alotaibi AM, Ismail AF, Aziman ES.

83. Spatial-temporal variation of extreme precipitation in the Yellow-Huai-Hai-Yangtze Basin of China.

Sci Rep

2023 Jun 8

Wang L, Wang J, He F

84. Colour opponency is widespread across the mouse subcortical visual system and differentially targets GABAergic and non-GABAergic neurons.

Sci Rep

2023 Jun 8

Feord RC(#), Gomoliszewska A(#), Pienaar A(#)

85. Porphyromonas gingivalis-odontogenic infection is the potential risk for progression of nonalcoholic steatohepatitis-related neoplastic nodule formation.

Sci Rep

2023 Jun 8

Sakamoto S, Nagasaki A, Shrestha M

86. Green preparation of graphene oxide nanosheets as adsorbent.

Sci Rep

2023 Jun 8

Cao K, Tian Z, Zhang X

87. Broad anti-pathogen potential of DEAD box RNA helicase eIF4A-targeting rocaglates.

Sci Rep

2023 Jun 8

Obermann W(#), Azri MFD(#), Konopka L

88. Identifying the source populations supplying a vital economic marine species for the New Zealand aquaculture industry.

Sci Rep

2023 Jun 8

Chaput R, Quigley CN, Weppe SB

89. Assessment of goal-directed behavior and prospective memory in adult ADHD with an online 3D videogame simulating everyday tasks.

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2023 Jun 8

Jylkkä J, Ritakallio L, Merzon L

90. All green sulfolane-based solvent enhanced electrical conductivity and rigidity of perovskite crystalline layer.

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2023 Jun 8

Siripraparat A(#), Mittanonsakul P(#), Pansa-Ngat P

91. Explaining population booms and busts in Mid-Holocene Europe.

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2023 Jun 8

Kondor D, Bennett JS, Gronenborn D

92. Wearable-based accelerometer activity profile as digital biomarker of inflammation, biological age, and mortality using hierarchical clustering analysis in NHANES 2011-2014.

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2023 Jun 8

Shim J, Fleisch E, Barata F.

93. Integrated control of non-motor and motor efforts during perceptual decision-making and action execution: a pilot study.

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2023 Jun 8

Leroy É, Koun É, Thura D.

94. Short-term outcomes and cost-effectiveness of laparoscopic gastrectomy with articulating instruments for gastric cancer compared with the robotic approach.

Sci Rep

2023 Jun 8

Lee CM, Park S, Park SH

95. Study on the driving mechanism of lagged effects based on different time scales in a karst drainage basin in South China.

Sci Rep

2023 Jun 8

He Z, Pan S, Gu X

Compared to earthquakes and volcanoes, drought is one of the most damaging natural disasters and is mainly affected by rainfall losses, especially by the runoff regulation ability of the underlying watershed surface. Based on monthly rainfall runoff data recorded from 1980 to 2020, in this study, the distributed lag regression model is used to simulate the rainfall-runoff process in the karst distribution region of South China, and a time series of watershed lagged-flow volumes is calculated. The watershed lagged effect is analyzed by four distribution models, and the joint probability between the lagged intensity and frequency is simulated by the copula function family. The results show that (1) the watershed lagged effects simulated by the normal, log-normal, P-III and log-logistic distribution models in the karst drainage basin are particularly significant, with small mean square errors (MSEs) and significant time-scale characteristics. (2) Affected by spatiotemporal distribution differences in rainfall and the impacts of different basin media and structures, the lag response of runoff to rainfall differs significantly among different time scales. Especially at the 1-, 3- and 12-month scales, the coefficient of variation (Cv) of the watershed lagged intensity is greater than 1, while it is less than 1 at the 6- and 9-month scales. (3) The lagged frequencies simulated by the log-normal, P-III and log-logistic distribution models are relatively high (with medium, medium-high and high frequencies, respectively), while that simulated by the normal distribution is relatively low (medium-low and low frequencies). (4) There is a significant negative correlation (R < - 0.8, Sig. < 0.01) between the watershed lagged intensity and frequency. For the joint probability simulation, the fitting effect of the gumbel Copula is the best, followed by the Clayton and Frank-1 copulas, and while that of the Frank-2 copula is relatively weak. Consequently, the propagation mechanism from meteorological drought to agricultural or hydrological drought and the conversion mechanism between agricultural and hydrological drought are effectively revealed in this study, thereby providing a scientific basis for the rational utilization of water resources and drought resistance and disaster relief in karst areas.

96. Propensity score matching analysis to comparing cisplatin versus nedaplatin based doublet agent concurrent chemoradiotherapy for locally advanced cervical cancer.

Sci Rep

2023 Jun 8

Zhang Y(#), Fan S(#), Shan M

97. Lessons on the COVID-19 pandemic: who are the most affected.

Sci Rep

2023 Jun 8

Xie J, Piao X, Managi S.

98. A comparative multi-level toxicity assessment of carbon-based Gd-free dots and Gd-doped nanohybrids from coffee waste: hematology, biochemistry, histopathology and neurobiology study.

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2023 Jun 8

Kuznietsova H, Dziubenko N, Paliienko K

99. A set of vectors and strains for chromosomal integration in fission yeast.

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2023 Jun 8

Matsuyama A, Hashimoto A, Nishimura S

100. Upgradation of methane in the biogas by hydrogenation of CO(2) in a prototype reactor with double pass operation over optimized Ni-Ce/Al-MCM-41 catalyst.

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2023 Jun 8

Aieamsam-Aung P, Srifa A, Koo-Amornpattana W

101. Assessing the impacts of dam/weir operation on streamflow predictions using LSTM across South Korea.

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2023 Jun 8

Kwon Y, Cha Y, Park Y

102. Participation and performance trends in short-, medium, and long-distance duathlon.

Sci Rep

2023 Jun 8

Turnwald J, Sousa CV, Andrade MS

Participation and performance trends of male and female athletes have been thoroughly analyzed in various endurance sports. Knowing these trends can help coaches and athletes prepare for competitions and may influence their training strategy and career planning. However, duathlon events-consisted of two splits of running (Run1 and Run2) interspersed by a split of cycling (Bike)-have not been thoroughly studied, unlike other endurance sports. The present study aimed to compare participation and performance trends in duathletes who competed in duathlon races hosted by World Triathlon or affiliated National Federations between 1990 and 2021. A total of 25,130 results of age group finishers who competed in run-bike-run duathlon races of varying distances were analyzed with different general linear models. Races were divided into three distances: short-distance (up to 5.5 km run, 21 km bike, 5 km run), medium-distance (5-10 km run, 30-42 km bike, 7-11 km run) and long-distance (at least 14 km run, 60 km bike, 25 km run). On average, women represented 45.6% of all finishers in short-distance, 39.6% in medium-distance and 24.9% in long-distance duathlon races. Throughout the years, men were consistently faster than women in all three race legs (Run 1, Bike, and Run 2) in all three distances across all age groups, and women could not reduce the performance gap. Concerning the age of peak performance, duathletes of the age group 30-34 finished most often in the top three in short- and medium-distance duathlons, whereas male duathletes of the age group 25-29 and female duathletes of the age group 30-34 finished most often in the top three in long-distance duathlons. Women participated less, especially in longer distances, and were constantly slower than men. Duathletes of the age group 30-34 finished most often in the top three. Future studies should analyze participation and performance trends in further subgroups (e.g., elite athletes) and pacing behaviours.

103. Identification of tumor tissue in thin pathological samples via femtosecond laser-induced breakdown spectroscopy and machine learning.

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2023 Jun 8

Sarpe C, Ciobotea ER, Morscher CB

104. Comparison of Oxford Nanopore Technologies and Illumina MiSeq sequencing with mock communities and agricultural soil.

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2023 Jun 8

Stevens BM, Creed TB, Reardon CL

Illumina MiSeq is the current standard for characterizing microbial communities in soil. The newer alternative, Oxford Nanopore Technologies MinION sequencer, is quickly gaining popularity because of the low initial cost and longer sequence reads. However, the accuracy of MinION, per base, is much lower than MiSeq (95% versus 99.9%). The effects of this difference in base-calling accuracy on taxonomic and diversity estimates remains unclear. We compared the effects of platform, primers, and bioinformatics on mock community and agricultural soil samples using short MiSeq, and short and full-length MinION 16S rRNA amplicon sequencing. For all three methods, we found that taxonomic assignments of the mock community at both the genus and species level matched expectations with minimal deviation (genus: 80.9-90.5%; species: 70.9-85.2% Bray-Curtis similarity); however, the short MiSeq with error correction (DADA2) resulted in the correct estimate of mock community species richness and much lower alpha diversity for soils. Several filtering strategies were tested to improve these estimates with varying results. The sequencing platform also had a significant influence on the relative abundances of taxa with MiSeq resulting in significantly higher abundances Actinobacteria, Chloroflexi, and Gemmatimonadetes and lower abundances of Acidobacteria, Bacteroides, Firmicutes, Proteobacteria, and Verrucomicrobia compared to the MinION platform. When comparing agricultural soils from two different sites (Fort Collins, CO and Pendleton, OR), methods varied in the taxa identified as significantly different between sites. At all taxonomic levels, the full-length MinION method had the highest similarity to the short MiSeq method with DADA2 correction with 73.2%, 69.3%, 74.1%, 79.3%, 79.4%, and 82.28% of the taxa at the phyla, class, order, family, genus, and species levels, respectively, showing similar patterns in differences between the sites. In summary, although both platforms appear suitable for 16S rRNA microbial community composition, biases for different taxa may make the comparison between studies problematic; and even with a single study (i.e., comparing sites or treatments), the sequencing platform can influence the differentially abundant taxa identified.

105. Impact of the South Atlantic Anomaly on radiation exposure at flight altitudes during solar minimum.

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2023 Jun 8

Meier MM, Berger T, Jahn T

106. Biomechanical performance of a novel light-curable bone fixation technique.

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2023 Jun 8

Schwarzenberg P(#), Colding-Rasmussen T(#), Hutchinson DJ

107. Design of phononic crystal using open resonators as harmful gases sensor.

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2023 Jun 8

Zaky ZA, Mohaseb MA, Hendy AS

108. A new planar feeding method of dielectric rod antenna using dielectric resonator.

Sci Rep

2023 Jun 7

Fakhte S.

109. Effects of tumor-infiltrating lymphocytes on nonresponse rate of neoadjuvant chemotherapy in patients with invasive breast cancer.

Sci Rep

2023 Jun 7

Qian XL(#), Xia XQ(#), Li YQ

110. Efficacy of atosiban for repeated implantation failure in frozen embryo transfer cycles.

Sci Rep

2023 Jun 7

Li X, Du Y, Han X

111. A novel PID controller for pressure control of artificial ventilator using optimal rule based fuzzy inference system with RCTO algorithm.

Sci Rep

2023 Jun 7

Acharya D, Das DK.

In order to improve the pressure tracking response of an artificial ventilator system, a novel proportional integral derivative (PID) controller is designed in the present work by utilizing an optimal rule-based fuzzy inference system (FIS) with a reshaped class-topper optimization algorithm (RCTO), which is named as (Fuzzy-PID). Firstly, a patient-hose blower-driven artificial ventilator model is considered, and the transfer function model is established. The ventilator is assumed to operate in pressure control mode. Then, a fuzzy-PID control structure is formulated such that the error and change in error between the desired airway pressure and actual airway pressure of the ventilator are set as inputs to the FIS. The gains of the PID controller (proportional gain, derivative gain, and integral gain) are set as outputs of the FIS. A reshaped class topper optimization algorithm (RCTO) is developed to optimize rules of the FIS to establish optimal coordination among the input and output variables of the FIS. Finally, the optimized Fuzzy-PID controller is examined for the ventilator under different scenarios such as parametric uncertainties, external disturbances, sensor noise, and a time-varying breathing pattern. In addition, the stability analysis of the system is carried out using the Nyquist stability method, and the sensitivity of the optimal Fuzzy-PID is examined for different blower parameters. The simulation results showed satisfactory results in terms of peak time, overshoot, and settling time for all cases, which were also compared with existing results. It is observed in the simulation results that the overshoot in the pressure profile is improved by 16% with the proposed optimal rule based fuzzy-PID as compared with randomly selected rules for the system. Settling time and peak time are also improved 60-80% compared to the existing method. The control signal generated by the proposed controller is also improved in magnitude by 80-90% compared to the existing method. With a lower magnitude, the control signal can also avoid actuator saturation problems.

112. Experimental study on the reasonable proportions of rock-like materials for water-induced strength degradation in rock slope model test.

Sci Rep

2023 Jun 7

Cui Y, Xu C, Xue L

113. Parallel and anti-parallel helical surface states for topological semimetals.

Sci Rep

2023 Jun 7

Zhang T, Murakami S.

114. Association of systemic adverse reaction patterns with long-term dynamics of humoral and cellular immunity after coronavirus disease 2019 third vaccination.

Sci Rep

2023 Jun 7

Yoshida M, Kobashi Y, Kawamura T

115. Small RNA sequencing analysis of peptide-affinity isolated plasma extracellular vesicles distinguishes pancreatic cancer patients from non-affected individuals.

Sci Rep

2023 Jun 7

Roy JW, Wajnberg G, Ouellette A

Pancreatic ductal adenocarcinoma (PDAC) has a high fatality rate, mainly due to its asymptomatic nature until late-stage disease and therefore delayed diagnosis that leads to a lack of timely treatment intervention. Consequently, there is a significant need for better methods to screen populations that are at high risk of developing PDAC. Such advances would result in earlier diagnosis, more treatment options, and ultimately better outcomes for patients. Several recent studies have applied the concept of liquid biopsy, which is the sampling of a biofluid (such as blood plasma) for the presence of disease biomarkers, to develop screening approaches for PDAC; several of these studies have focused on analysis of extracellular vesicles (EVs) and their cargoes. While these studies have identified many potential biomarkers for PDAC that are present within EVs, their application to clinical practice is hindered by the lack of a robust, reproducible method for EV isolation and analysis that is amenable to a clinical setting. Our previous research has shown that the Vn96 synthetic peptide is indeed a robust and reproducible method for EV isolation that has the potential to be used in a clinical setting. We have therefore chosen to investigate the utility of the Vn96 synthetic peptide for this isolation of EVs from human plasma and the subsequent detection of small RNA biomarkers of PDAC by Next-generation sequencing (NGS) analysis. We find that analysis of small RNA from Vn96-isolated EVs permits the discrimination of PDAC patients from non-affected individuals. Moreover, analyses of all small RNA species, miRNAs, and lncRNA fragments are most effective at segregating PDAC patients from non-affected individuals. Several of the identified small RNA biomarkers have been previously associated with and/or characterized in PDAC, indicating the validity of our findings, whereas other identified small RNA biomarkers may have novel roles in PDAC or cancer in general. Overall, our results provide a basis for a clinically-amendable detection and/or screening strategy for PDAC using a liquid biopsy approach that relies on Vn96-mediated isolation of EVs from plasma.

116. In-vitro and in-silico evidence for oxidative stress as drivers for RDW.

Sci Rep

2023 Jun 7

Joosse HJ, van Oirschot BA, Kooijmans SAA

117. MHD Free convection flows of Jeffrey fluid with Prabhakar-like fractional model subject to generalized thermal transport.

Sci Rep

2023 Jun 7

Siddique I, Adrees R, Ahmad H

118. Validation of urinary reproductive hormone measurements using a novel smartphone connected reader.

Sci Rep

2023 Jun 7

Pattnaik S, Das D, Venkatesan VA.

Home use tests to monitor hormone trends during the menstrual cycle have been available over-the-counter for a long time. However, these tests often depend upon manual readouts and hence may lead to false analysis. Furthermore, a lot of these tests are also not quantitative. The aim of this study was to evaluate the accuracy of the quantitative home-based fertility monitor, Inito Fertility Monitor (IFM) and to use it to identify novel hormone trends in natural menstrual cycles. There were two aspects to our analysis: (i) Evaluating the efficacy of Inito Fertility Monitor in the measurement of urinary Estrone-3-glucuronide (E3G), Pregnanediol glucuronide (PdG) and Luteinizing hormone (LH), and (ii) A retrospective study of patients' hormone profiles using IFM. To evaluate the efficacy, the recovery percentage of the three hormones from IFM was evaluated using standard spiked solutions, the accuracy of measurement was calculated and the correlation between reproducible values from IFM and ELISA was established. During the validation of IFM, novel hormone trends were also observed. In order to reinforce the observations, a second group of 52 women was recruited. Assessment of the accuracy of IFM and evaluation of the volunteer urine samples was performed in a laboratory. Home assessment of hormone analysis was carried out using IFM. For the validation study, 100 women aged 21-45 years with cycle lengths ranging from 21 to 42 days were recruited. The participants had no previously diagnosed infertility conditions and their cycle lengths did not vary for more than 3 days from the expected cycle length. Daily first morning urine samples were collected from these 100 women. For the second group, 52 women were selected meeting the same criteria set for the validation study and IFM was provided to these women for testing at home. Coefficient of variation and recovery percentage of IFM with respect to laboratory based ELISA. Percentage occurrence of novel hormone trends and AUC analysis of a novel criteria identified for confirming ovulation. We observed that with all three hormones, IFM had an accurate recovery percentage. We found that the assay has an average CV of 5.05% in PdG measurement, 4.95% in E3G measurement and 5.57% in LH measurement. Furthermore, in predicting the concentration of E3G, PdG and LH in urine samples, we show that IFM has a high correlation with ELISA. In this study, we could also reproduce hormones trends across the menstrual cycle that have been observed by previous studies. We also identified a novel criterion for earlier confirmation of ovulation which could accurately distinguish ovulatory from anovulatory cycles with 100% specificity and had an area under the ROC curve of 0.98. In addition, we identified a new hormone trend which could be observed in 94.5% of the ovulatory cycles. The Inito Fertility Monitor is an effective tool for calculating the urinary concentrations of E3G, PdG and LH and can also be used to provide accurate fertility scores and confirm ovulation. We show that certain hormone trends associated with urinary E3G, PdG and LH could be accurately captured using IFM. In addition, we report a novel criterion for earlier confirmation of ovulation compared to existing criteria. Finally, we present a novel hormone pattern associated with most of the menstrual cycles by examining hormone profiles from the volunteers recruited for the clinical trial.Trial registration: The trial is registered at the current controlled trials ISRCTN registry #ISRCTN15534557.

119. ATP6AP2 is robustly expressed in pancreatic β cells and neuroendocrine tumors, and plays a role in maintaining cellular viability.

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2023 Jun 7

Taguchi T, Kimura K, Suzuki A

120. Association analysis of gut microbiota-metabolites-neuroendocrine changes in male rats acute exposure to simulated altitude of 5500 m.

Sci Rep

2023 Jun 7

Wang J, Liu S, Xie Y

121. High spin current density in gate-tunable spin-valves based on graphene nanoribbons.

Sci Rep

2023 Jun 7

Wang CP, Cheng SH, Hsueh WJ.

122. Three-dimensional growth and biomechanical risk progression of abdominal aortic aneurysms under serial computed tomography assessment.

Sci Rep

2023 Jun 7

Siika A, Bogdanovic M, Liljeqvist ML

123. Comprehensive RNA-Seq-based study and metabolite profiling to identify genes involved in podophyllotoxin biosynthesis in Linum album Kotschy ex Boiss. (Linaceae).

Sci Rep

2023 Jun 7

Danaeipour Z, Garoosi G, Tohidfar M

124. Autonomic responses during bladder hydrodistention under general versus spinal anaesthesia in patients with interstitial cystitis/bladder pain syndrome: a randomized clinical trial.

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2023 Jun 7

Kim YJ, Yoon HK, Kang YJ

125. The efficacy of direct oral anticoagulants in patients on concomitant treatment with levetiracetam.

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2023 Jun 7

Mavri A, Ilc S.

126. Inflammatory markers may mediate the relationship between processed meat consumption and metabolic unhealthy obesity in women: a cross sectional study.

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2023 Jun 7

Mohamadi A, Shiraseb F, Mirzababaei A

127. Differentiation of retroperitoneal paragangliomas and schwannomas based on computed tomography radiomics.

Sci Rep

2023 Jun 7

Cao Y(#), Wang Z(#), Ren J(#)

The purpose of this study was to differentiate the retroperitoneal paragangliomas and schwannomas using computed tomography (CT) radiomics. This study included 112 patients from two centers who pathologically confirmed retroperitoneal pheochromocytomas and schwannomas and underwent preoperative CT examinations. Radiomics features of the entire primary tumor were extracted from non-contrast enhancement (NC), arterial phase (AP) and venous phase (VP) CT images. The least absolute shrinkage and selection operator method was used to screen out key radiomics signatures. Radiomics, clinical and clinical-radiomics combined models were built to differentiate the retroperitoneal paragangliomas and schwannomas. Model performance and clinical usefulness were evaluated by receiver operating characteristic curve, calibration curve and decision curve. In addition, we compared the diagnostic accuracy of radiomics, clinical and clinical-radiomics combined models with radiologists for pheochromocytomas and schwannomas in the same set of data. Three NC, 4 AP, and 3 VP radiomics features were retained as the final radiomics signatures for differentiating the paragangliomas and schwannomas. The CT characteristics CT attenuation value of NC and the enhancement magnitude at AP and VP were found to be significantly different statistically (P < 0.05). The NC, AP, VP, Radiomics and clinical models had encouraging discriminative performance. The clinical-radiomics combined model that combined radiomics signatures and clinical characteristics showed excellent performance, with an area under curve (AUC) values were 0.984 (95% CI 0.952-1.000) in the training cohort, 0.955 (95% CI 0.864-1.000) in the internal validation cohort and 0.871 (95% CI 0.710-1.000) in the external validation cohort. The accuracy, sensitivity and specificity were 0.984, 0.970 and 1.000 in the training cohort, 0.960, 1.000 and 0.917 in the internal validation cohort and 0.917, 0.923 and 0.818 in the external validation cohort, respectively. Additionally, AP, VP, Radiomics, clinical and clinical-radiomics combined models had a higher diagnostic accuracy for pheochromocytomas and schwannomas than the two radiologists. Our study demonstrated the CT-based radiomics models has promising performance in differentiating the paragangliomas and schwannomas.

128. Decomposing solar and geomagnetic activity and seasonal dependencies to examine the relationship between GPS loss of lock and ionospheric turbulence.

Sci Rep

2023 Jun 7

Lovati G, De Michelis P, Consolini G

129. Trust and COVID-19 vaccine hesitancy.

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2023 Jun 7

Carrieri V, Guthmuller S, Wübker A.

130. AI aided workflow for hip dysplasia screening using ultrasound in primary care clinics.

Sci Rep

2023 Jun 7

Jaremko JL, Hareendranathan A, Bolouri SES

131. GTMNet: a vision transformer with guided transmission map for single remote sensing image dehazing.

Sci Rep

2023 Jun 7

Li H, Zhang Y, Liu J

132. Tribological performance of high chromium white cast iron and heat-treated steel used in barite crushing industry.

Sci Rep

2023 Jun 7

Zouch F, Bahri A, Antar Z

133. Calibration and verification of DEM parameters of wet-sticky feed raw materials.

Sci Rep

2023 Jun 7

Peng F, Zhang L, Li Z

134. Overgrowth of long bone in rabbits by growth stimulation through metaphyseal hole creation.

Sci Rep

2023 Jun 7

Lee KM, Ko EA, Shah M

135. Real-time measurements of vascular permeability in the mouse eye using vitreous fluorophotometry.

Sci Rep

2023 Jun 7

Colé N, Thoele J, Ullmer C

136. A comparison of peripapillary vessel density between subjects with normal-tension glaucoma and primary open-angle glaucoma with similar extents of glaucomatous damage.

Sci Rep

2023 Jun 7

Lee MW(#), Yu HY, Park KS

137. Oxidative damage contributes to bisphenol S-induced development block at 2-cell stage preimplantation embryos in mice through inhibiting of embryonic genome activation.

Sci Rep

2023 Jun 7

Ning A, Xiao N, Wang H

138. Comprehensive analysis of the coding and non-coding RNA transcriptome expression profiles of hippocampus tissue in tx-J animal model of Wilson's disease.

Sci Rep

2023 Jun 7

Wang D, Xie D, Zhang J

Wilson's disease (WD) is an autosomal recessive disorder with a genetic basis. The predominant non-motor symptom of WD is cognitive dysfunction, although the specific genetic regulatory mechanism remains unclear. Tx-J mice, with an 82% sequence homology of the ATP7B gene to the human gene, are considered the most suitable model for WD. This study employs deep sequencing to investigate the differences in RNA transcript profiles, both coding and non-coding, as well as the functional characteristics of the regulatory network involved in WD cognitive impairment. The cognitive function of tx-J mice was evaluated using the Water Maze Test (WMT). Long non-coding RNA (lncRNA), circular RNA (circRNA), and messenger RNA (mRNA) profiles were analyzed in the hippocampal tissue of tx-J mice to identify differentially expressed RNAs (DE-RNAs). Subsequently, the DE-RNAs were used to construct protein-protein interaction (PPI) networks, as well as DE-circRNAs and lncRNAs-associated competing endogenous RNA (ceRNA) expression networks, and coding-noncoding co-expression (CNC) networks. To elucidate their biological functions and pathways, the PPI and ceRNA networks were subjected to Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis. A total of 361 differentially expressed mRNAs (DE-mRNAs), comprising 193 up-regulated and 168 down-regulated mRNAs, 2627 differentially expressed long non-coding RNAs (DE-lncRNAs), consisting of 1270 up-regulated and 1357 down-regulated lncRNAs, and 99 differentially expressed circular RNAs (DE-circRNAs), consisting of 68 up-regulated and 31 down-regulated circRNAs, were observed in the tx-J mice group when compared to the control mice group. Gene Ontology (GO) and pathway analyses revealed that DE-mRNAs were enriched in cellular processes, calcium signaling pathways, and mRNA surveillance pathways. In contrast, the DE-circRNAs-associated competing endogenous RNA (ceRNA) network was enriched for covalent chromatin modification, histone modification, and axon guidance, whereas the DE-lncRNAs-associated ceRNA network was enriched for dendritic spine, regulation of cell morphogenesis involved in differentiation, and mRNA surveillance pathway. The study presented the expression profiles of lncRNA, circRNA, and mRNA in the hippocampal tissue of tx-J mice. Furthermore, the study constructed PPI, ceRNA, and CNC expression networks. The findings are significant in comprehending the function of regulatory genes in WD associated with cognitive impairment. These results also offer valuable information for the diagnosis and treatment of WD.

139. How transform fault shear influences where detachment faults form near mid-ocean ridges.

Sci Rep

2023 Jun 7

Schierjott JC, Ito G, Behn MD

140. The rhythm of chemotherapy and the felt experience of time: a front-loaded phenomenological retrospective cohort study.

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2023 Jun 7

Moskalewicz M, Kordel P, Kokociński M

141. Effect of high-speed steel screw drill geometry on cutting performance when machining austenitic stainless steel.

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2023 Jun 7

Sedlak J, Zouhar J, Kolomy S

142. Analysis of navigational risk indicators as a function of the ship's domain width for the selected offshore wind farm in the Baltic Sea.

Sci Rep

2023 Jun 7

Rutkowski G, Kubacka M.

143. Country-level predictors of COVID-19 mortality.

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2023 Jun 7

Brown PA.

144. Combining machine learning with Cox models to identify predictors for incident post-menopausal breast cancer in the UK Biobank.

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2023 Jun 7

Liu X, Morelli D, Littlejohns TJ

145. Stochastic optimization of a uranium oxide reaction mechanism using plasma flow reactor measurements.

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2023 Jun 7

Finko M, Koroglu B, Rodriguez KE

146. Cigarette smoke extract impairs gingival epithelial barrier function.

Sci Rep

2023 Jun 7

Yamaga S(#), Tanigaki K(#), Nakamura E

147. Isolation and characterization of bacteriophages from soil against food spoilage and foodborne pathogenic bacteria.

Sci Rep

2023 Jun 7

Artawinata PC, Lorraine S, Waturangi DE.

148. Recycling of both resin and fibre from wind turbine blade waste via small molecule-assisted dissolution.

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2023 Jun 7

Muzyka R, Sobek S, Korytkowska-Wałach A

149. Simultaneous determination of 2-(3-hydroxy-5-phosphonooxymethyl-2-methyl-4-pyridyl)-1,3-thiazolidine-4-carboxylic acid and main plasma aminothiols by HPLC-UV based method.

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2023 Jun 7

Piechocka J, Wyszczelska-Rokiel M, Głowacki R.

150. Combined association of physical activity and sitting time with cardiometabolic risk factors in Chilean adults.

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2023 Jun 7

Estrada-Saldaña E, Marques A, Silva DR

151. Analysis and design of holographic magnetic metasurfaces in the very near field for sensing applications at quasi-static regime.

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2023 Jun 7

Falchi M, Rotundo S, Brizi D

152. Electrical parameters extraction of PV modules using artificial hummingbird optimizer.

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2023 Jun 7

El-Sehiemy R, Shaheen A, El-Fergany A

153. Association of obesity, diabetes, and hypertension with arsenic in drinking water in the Comarca Lagunera province (north-central Mexico).

Sci Rep

2023 Jun 7

Sánchez-Rodríguez BL, Castillo-Maldonado I, Pedroza-Escobar D

154. A nomogram for predicting cancer-specific survival in patients with uterine clear cell carcinoma: a population-based study.

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2023 Jun 7

Cheng WL, Wang RM, Zhao Y

155. Correlation versus hybridization gap in CaMn[Formula: see text]Bi[Formula: see text].

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2023 Jun 7

Lane C, Piva MM, Rosa PFS

156. DEDTI versus IEDTI: efficient and predictive models of drug-target interactions.

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2023 Jun 7

Zabihian A, Sayyad FZ, Hashemi SM

157. High dose of dexamethasone attenuates docetaxel-induced fluid retention in breast cancer treatment.

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2023 Jun 7

Saito Y, Kanno R, Takekuma Y

158. Association of reproductive factors and exogenous hormone use with distal sensory polyneuropathy among postmenopausal women in the United States: results from 1999 to 2004 NHANES.

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2023 Jun 7

Li J, Chongpison Y(#), Amornvit J

159. On learning agent-based models from data.

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2023 Jun 7

Monti C(#), Pangallo M(#), De Francisci Morales G

160. Designed α-sheet peptides disrupt uropathogenic E. coli biofilms rendering bacteria susceptible to antibiotics and immune cells.

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2023 Jun 7

Bleem A, Prosswimmer T, Chen R

161. The GET pathway is a major bottleneck for maintaining proteostasis in Saccharomyces cerevisiae.

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2023 Jun 7

Josefson R, Kumar N, Hao X

162. Assessing falls in the elderly population using G-STRIDE foot-mounted inertial sensor.

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2023 Jun 6

Álvarez MN(#), Ruiz ARJ(#), Neira GG(#)

163. Local atomic structure studies of Zr(55)Cu(35)Al(10) alloy around T(g).

Sci Rep

2023 Jun 6

Zhao J, Chen Y, Shao C

164. Synergistic antibacterial effect of copper and silver nanoparticles and their mechanism of action.

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2023 Jun 6

Vasiliev G, Kubo AL, Vija H

Bacterial infections are one of the leading causes of death worldwide. In the case of topical bacterial infections such as wound infections, silver (Ag) has historically been one of the most widely used antibacterials. However, scientific publications have demonstrated the adverse effects of silver on human cells, ecotoxicity and insufficient antibacterial effect for the complete elimination of bacterial infections. The use of Ag in the form of nanoparticles (NPs, 1-100 nm) allows to control the release of antibacterial Ag ions but is still not sufficient to eliminate infection and avoid cytotoxicity. In this study, we tested the potency of differently functionalized copper oxide (CuO) NPs to enhance the antibacterial properties of Ag NPs. The antibacterial effect of the mixture of CuO NPs (CuO, CuO-NH2 and CuO-COOH NPs) with Ag NPs (uncoated and coated) was studied. CuO and Ag NP combinations were more efficient than Cu or Ag (NPs) alone against a wide range of bacteria, including antibiotic-resistant strains such as gram-negative Escherichia coli and Pseudomonas aeruginosa as well as gram-positive Staphylococcus aureus, Enterococcus faecalis and Streptococcus dysgalactiae. We showed that positively charged CuO NPs enhanced the antibacterial effect of Ag NPs up to 6 times. Notably, compared to the synergy of CuO and Ag NPs, the synergy of respective metal ions was low, suggesting that NP surface is required for the enhanced antibacterial effect. We also studied the mechanisms of synergy and showed that the production of Cu+ ions, faster dissolution of Ag+ from Ag NPs and lower binding of Ag+ by proteins of the incubation media in the presence of Cu2+ were the main mechanisms of the synergy. In summary, CuO and Ag NP combinations allowed increasing the antibacterial effect up to 6 times. Thus, using CuO and Ag NP combinations enables to retain excellent antibacterial effects due to Ag and synergy and enhances beneficial effects, since Cu is a vital microelement for human cells. Thus, we suggest using combinations of Ag and CuO NPs in antibacterial materials, such as wound care products, to increase the antibacterial effect of Ag, improve safety and prevent and cure topical bacterial infections.

165. Neem leaf powder (Azadirachta indica) mitigates oxidative stress and pathological alterations triggered by lead toxicity in Nile tilapia (Oreochromis niloticus).

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2023 Jun 6

Abu-Elala NM, Khattab MS, AbuBakr HO

166. Silicon in the form of nanosilica mitigates P toxicity in scarlet eggplant.

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2023 Jun 6

Alves DMR, de Oliveira JN, de Mello Prado R

167. Hyperglycemia-activated 11β-hydroxysteroid dehydrogenase type 1 increases endoplasmic reticulum stress and skin barrier dysfunction.

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2023 Jun 6

Lee YB, Hwang HJ, Kim E

168. Clinical course and risk factors for development and progression of interstitial lung disease in primary Sjögren's syndrome.

Sci Rep

2023 Jun 6

Lee KA(#), Nam BD(#), Hwang JH

169. Establishment and characterization of patient-derived xenograft of a rare pediatric anaplastic pleomorphic xanthoastrocytoma (PXA) bearing a CDC42SE2-BRAF fusion.

Sci Rep

2023 Jun 6

Damayanti NP(#), Saadatzadeh MR(#), Dobrota E

Pleomorphic xanthoastrocytoma (PXA) is a rare subset of primary pediatric glioma with 70% 5-year disease free survival. However, up to 20% of cases present with local recurrence and malignant transformation into more aggressive type anaplastic PXA (AXPA) or glioblastoma. The understanding of disease etiology and mechanisms driving PXA and APXA are limited, and there is no standard of care. Therefore, development of relevant preclinical models to investigate molecular underpinnings of disease and to guide novel therapeutic approaches are of interest. Here, for the first time we established, and characterized a patient-derived xenograft (PDX) from a leptomeningeal spread of a patient with recurrent APXA bearing a novel CDC42SE2-BRAF fusion. An integrated -omics analysis was conducted to assess model fidelity of the genomic, transcriptomic, and proteomic/phosphoproteomic landscapes. A stable xenoline was derived directly from the patient recurrent tumor and maintained in 2D and 3D culture systems. Conserved histology features between the PDX and matched APXA specimen were maintained through serial passages. Whole exome sequencing (WES) demonstrated a high degree of conservation in the genomic landscape between PDX and matched human tumor, including small variants (Pearson's r = 0.794-0.839) and tumor mutational burden (~ 3 mutations/MB). Large chromosomal variations including chromosomal gains and losses were preserved in PDX. Notably, chromosomal gain in chromosomes 4-9, 17 and 18 and loss in the short arm of chromosome 9 associated with homozygous 9p21.3 deletion involving CDKN2A/B locus were identified in both patient tumor and PDX sample. Moreover, chromosomal rearrangement involving 7q34 fusion; CDC42SE-BRAF t (5;7) (q31.1, q34) (5:130,721,239, 7:140,482,820) was identified in the PDX tumor, xenoline and matched human tumor. Transcriptomic profile of the patient's tumor was retained in PDX (Pearson r = 0.88) and in xenoline (Pearson r = 0.63) as well as preservation of enriched signaling pathways (FDR Adjusted P < 0.05) including MAPK, EGFR and PI3K/AKT pathways. The multi-omics data of (WES, transcriptome, and reverse phase protein array (RPPA) was integrated to deduce potential actionable pathways for treatment (FDR < 0.05) including KEGG01521, KEGG05202, and KEGG05200. Both xenoline and PDX were resistant to the MEK inhibitors trametinib or mirdametinib at clinically relevant doses, recapitulating the patient's resistance to such treatment in the clinic. This set of APXA models will serve as a preclinical resource for developing novel therapeutic regimens for rare anaplastic PXAs and pediatric high-grade gliomas bearing BRAF fusions.

170. Leveraging human expert image annotations to improve pneumonia differentiation through human knowledge distillation.

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2023 Jun 6

Schaudt D, von Schwerin R, Hafner A

171. Self-regulation of visual word form area activation with real-time fMRI neurofeedback.

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2023 Jun 6

Haugg A(#), Frei N(#), Menghini M

172. The meta-analysis and systematic review of prevalence and clinical anatomy of the arc of Buhler.

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2023 Jun 6

Kowalczyk KA, Pękala J, Kawzowicz M

173. Computational simulation for MHD peristaltic transport of Jeffrey fluid with density-dependent parameters.

Sci Rep

2023 Jun 6

Ibrahim MG, Abou-Zeid MY.

174. Kimberlite eruptions driven by slab flux and subduction angle.

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2023 Jun 6

Mather BR, Müller RD, Alfonso CP

175. Neutron imaging for magnetization inside an operating inductor.

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2023 Jun 6

Mamiya H, Oba Y, Terada N

176. Mechanical properties of additively manufactured zirconia with alumina air abrasion surface treatment.

Sci Rep

2023 Jun 6

Yoo LG, Pang NS, Kim SH

This study aimed to evaluate the mechanical properties of zirconia fabricated using additive manufacturing technology and compare them to those of zirconia fabricated using subtractive manufacturing technology. Sixty disc-shaped specimens were fabricated for the additive (n = 30) and subtractive manufacturing groups (n = 30), and each group was divided into two subgroups according to their air-abrasion surface treatment: control (n = 15) and air-abrasion groups (n = 15). Mechanical properties including the flexural strength (FS), Vickers hardness, and surface roughness were determined, and the values were analyzed by one-way ANOVA and Tukey's post hoc test (α = 0.05). X-ray diffraction and scanning electron microscopy were used for phase analysis and surface topography evaluation, respectively. The SMA group exhibited the highest FS (1144.97 ± 168.1 MPa), followed by the SMC (944.58 ± 141.38 MPa), AMA (905.02 ± 111.38 MPa), and AMC groups (763.55 ± 68.69 MPa). The Weibull distribution showed the highest scale value (1213.55 MPa) in the SMA group, with the highest shape value in the AMA group (11.69). A monoclinic peak was not detected in both the AMC and SMC groups, but after air abrasion, the monoclinic phase content ([Formula: see text]) reached 9% in the AMA group, exceeding that in the SMA group (7%). The AM groups exhibited statistically lower FS values than those of the SM groups under the same surface treatment (p < 0.05). Air-abrasion surface treatment increased the monoclinic phase content and FS (p < 0.05) in both the additive and subtractive groups, while it increased the surface roughness (p < 0.05) only in the additive group and did not affect the Vickers hardness in either group. For zirconia manufactured using additive technology, the mechanical properties are comparable to those of zirconia manufactured using subtractive technology.

177. Molecular basis for the recognition of 24-(S)-hydroxycholesterol by integrin αvβ3.

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2023 Jun 6

Gc JB(#), Chen J(#), Pokharel SM

178. Opposite modulation of functional recovery following contusive spinal cord injury in mice with oligodendrocyte-selective deletions of Atf4 and Chop/Ddit3.

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2023 Jun 6

Gao Y, Wei GZ, Forston MD

179. Multiscale (microscopic to remote sensing) preliminary exploration of auriferous-uraniferous marbles: A case study from the Egyptian Nubian Shield.

Sci Rep

2023 Jun 6

Shebl A, Hamdy M.

Since their recent first record within the Egyptian Nubian Shield, auriferous and uraniferous marbles (Au = 0.98-2.76 g/t; U = 133-640 g/t) have rarely been addressed, despite not only their probable economic importance but also the fact that it is a new genetic style of gold and uranium mineralization in the Nubian Shield rocks. This is mainly attributed to the inadequate localization of these marbles within harsh terrains, as well as the cost and time spent with conventional fieldwork for their identification compared to the main lithological components of the Nubian Shield. On the contrary, remote sensing and machine learning techniques save time and effort while introducing reliable feature identification with reasonable accuracy. Consequently, the current research is an attempt to apply the well-known machine learning algorithm (Support vector Machine-SVM) over Sentinel 2 remote sensing data (with a spatial resolution of up to 10 m) to delineate the distribution of auriferous-uraniferous marbles in the Barramiya-Daghbagh district (Eastern Desert of Egypt), as a case study from the Nubian Shield. Towards better results, marbles were accurately distinguished utilizing ALOS PRISM (2.5 m) pan-sharpened Sentinel 2 data and well-known exposures during fieldwork. With an overall accuracy of more than 90%, a thematic map for auriferous-uraniferous marbles and the major rock units in the Barramiya-Daghbagh district was produced. Marbles are spatially related to ophiolitic serpentinite rocks, as consistent with their genesis within the Neoproterozoic oceanic lithosphere. Field and petrographic investigations have confirmed the newly detected Au and U-bearing zones (impure calcitic to impure dolomitic marbles in Wadi Al Barramiya and Wadi Daghbagh areas and impure calcitic marble in Gebel El-Rukham area). Additionally, X-ray diffraction (XRD), back-scattered electron images (BSEIs), and Energy Dispersive X-ray spectroscopy (EDX) results were integrated to verify our remote sensing results and petrographic investigations. Different times of mineralization are indicated, ranging from syn-metamorphism (gold in Wadi Al Barramiya and Gebel El-Rukham) to post-metamorphism (gold in Wadi Daghbagh and uranium in all locations). Based on the application of geological, mineralogical, machine learning and remote sensing results for the construction of a preliminary exploration model of the auriferous-uraniferous marble in the Egyptian Nubian Shield, we recommend a detailed exploration of Au and U-bearing zones in Barramiya-Dghbagh district and applying the adopted approach to other districts of similar geological environments.

180. Effect of situation similarity on younger and older adults' episodic simulation of helping behaviours.

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2023 Jun 6

Ryan AD, Smitko R, Campbell KL.

181. Development and validation of a simple-to-use nomogram for self-screening the risk of dyslipidemia.

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2023 Jun 6

Lan J, Zhou X(#), Huang Q(#)

182. A novel effective bio-originated methylene blue adsorbent: the porous biosilica from three marine diatom strains of Nanofrustulum spp. (Bacillariophyta).

Sci Rep

2023 Jun 6

Golubeva A, Roychoudhury P, Dąbek P

183. Synthesis, structural characterization, and antimicrobial evaluation of new mononuclear mixed ligand complexes based on furfural-type imine ligand, and 2,2'-bipyridine.

Sci Rep

2023 Jun 6

Ismail BA, Abd El-Wahab ZH, Ali OAM

184. Improvement of retinal function in Alzheimer disease-associated retinopathy by dietary lysophosphatidylcholine-EPA/DHA.

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2023 Jun 6

Sugasini D, Park JC, McAnany JJ

185. Site-directed mutagenesis of Mycobacterium tuberculosis and functional validation to investigate potential bedaquiline resistance-causing mutations.

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2023 Jun 6

Otum CC, Rivière E, Barnard M

186. Metabolic dysfunction-associated fatty liver disease in people living with HIV.

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2023 Jun 6

Michel M, Labenz C, Armandi A

187. Ebselen derivatives inhibit SARS-CoV-2 replication by inhibition of its essential proteins: PL(pro) and M(pro) proteases, and nsp14 guanine N7-methyltransferase.

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2023 Jun 6

Zmudzinski M, Rut W, Olech K

188. Integrated ultrasonographic approach to evaluate fluid responsiveness in critically ill patients.

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2023 Jun 6

Innocenti F, Savinelli C, Coppa A

189. Comparative mitogenome analyses of twelve non-biting flies and provide insights into the phylogeny of Chironomidae (Diptera: Culicomorpha).

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2023 Jun 6

Fang X, Wang X, Mao B

190. A real-world data validation of the value of early-stage SIR modelling to public health.

Sci Rep

2023 Jun 6

Liu T(#), Huang J(#), He Z

Performance of Susceptible-Infected-Recovered (SIR) model in the early stage of a novel epidemic may be hindered by data availability. Additionally, the traditional SIR model may oversimplify the disease progress, and knowledge about the virus and transmission is limited early in the epidemic, resulting in a greater uncertainty of such modelling. We aimed to investigate the impact of model inputs on the early-stage SIR projection using COVID-19 as an illustration to evaluate the application of early infection models. We constructed a modified SIR model using discrete-time Markov chain to simulate daily epidemic dynamics and estimate the number of beds needed in Wuhan in the early stage of COVID-19 epidemic. We compared eight scenarios of SIR projection to the real-world data (RWD) and used root mean square error (RMSE) to assess model performance. According to the National Health Commission, the number of beds occupied in isolation wards and ICUs due to COVID-19 in Wuhan peaked at 37,746. In our model, as the epidemic developed, we observed an increasing daily new case rate, and decreasing daily removal rate and ICU rate. This change in rates contributed to the growth in the needs of bed in both isolation wards and ICUs. Assuming a 50% diagnosis rate and 70% public health efficacy, the model based on parameters estimated using data from the day reaching 3200 to the day reaching 6400 cases returned a lowest RMSE. This model predicted 22,613 beds needed in isolation ward and ICU as on the day of RWD peak. Very early SIR model predictions based on early cumulative case data initially underestimated the number of beds needed, but the RMSEs tended to decline as more updated data were used. Very-early-stage SIR model, although simple but convenient and relatively accurate, is a useful tool to provide decisive information for the public health system and predict the trend of an epidemic of novel infectious disease in the very early stage, thus, avoiding the issue of delay-decision and extra deaths.

191. Adipose tissue is associated with kidney function parameters.

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2023 Jun 6

Mueller-Peltzer K(#), von Krüchten R(#), Lorbeer R

192. Genetic least square estimation approach to wind power curve modelling and wind power prediction.

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2023 Jun 6

Wang Z, Wang X, Liu W.

193. Amine functionalized benzene based hypercrosslinked polymer as an adsorbent for CO(2)/N(2) adsorption.

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2023 Jun 6

Moradi MR, Torkashvand A, Ramezanipour Penchah H

194. In-plane gate graphene transistor with epitaxially grown molybdenum disulfide passivation layers.

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2023 Jun 6

Tsai PC, Huang CW, Chang SJ

195. Evaluation of pharyngeal airway space after orthodontic extraction treatment in class II malocclusion integrating with the subjective sleep quality assessment.

Sci Rep

2023 Jun 6

Vejwarakul W, Ko EW, Lin CH.

196. Development of a program to determine optimal settings for robot-assisted rehabilitation of the post-stroke paretic upper extremity: a simulation study.

Sci Rep

2023 Jun 6

Takebayashi T, Uchiyama Y, Okita Y

Robot-assisted therapy can effectively treat upper extremity (UE) paralysis in patients who experience a stroke. Presently, UE, as a training item, is selected according to the severity of the paralysis based on a clinician's experience. The possibility of objectively selecting robot-assisted training items based on the severity of paralysis was simulated using the two-parameter logistic model item response theory (2PLM-IRT). Sample data were generated using the Monte Carlo method with 300 random cases. This simulation analyzed sample data (categorical data with three difficulty values of 0, 1, and 2 [0: too easy, 1: adequate, and 2: too difficult]) with 71 items per case. First, the most appropriate method was selected to ensure the local independence of the sample data necessary to use 2PLM-IRT. The method was to exclude items with low response probability (maximum response probability) within a pair in the Quality of Compensatory Movement Score (QCM) 1-point item difficulty curve, items with low item information content within a pair in the QCM 1-point item difficulty curve, and items with low item discrimination. Second, 300 cases were analyzed to determine the most appropriate model (one-parameter or two-parameter item response therapy) to be used and the most favored method to establish local independence. We also examined whether robotic training items could be selected according to the severity of paralysis based on the ability of a person (θ) in the sample data as calculated by 2PLM-IRT. Excluding items with low response probability (maximum response probability) in a pair in the categorical data 1-point item difficulty curve was effective in ensuring local independence. Additionally, to ensure local independence, the number of items should be reduced to 61 from 71, indicating that the 2PLM-IRT was an appropriate model. The ability of a person (θ) calculated by 2PLM-IRT suggested that seven training items could be estimated from 300 cases according to severity. This simulation made it possible to objectively estimate the training items according to the severity of paralysis in a sample of approximately 300 cases using this model.

197. New findings on choroidal features in healthy people by ultra-widefield swept-source optical coherence tomography angiography.

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2023 Jun 6

Liu X(#), Chen S(#), Leng H

198. A computationally efficient algorithm for wearable sleep staging in clinical populations.

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2023 Jun 6

Fonseca P, Ross M, Cerny A

199. Longitudinal torsional vibrations of the chain drive system of mine scraper conveyor.

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2023 Jun 6

Lu J, Yang R, Mao J

200. Applied research of comprehensive advance geological prediction in Daluoshan water diversion tunnel.

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2023 Jun 6

Liu M, Gan Q.

201. Analysis of β-nerve growth factor and its precursor during human pregnancy by immunoaffinity-liquid chromatography tandem mass spectrometry.

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2023 Jun 6

Walsh J, Palandra J, Goihberg E

202. Light conditions influence optic nerve OCT angiography parameter in healthy subjects with neutral pupils.

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2023 Jun 6

Nelis P(#), Nieweler A(#), Brücher V

203. A deep learning predictive model for public health concerns and hesitancy toward the COVID-19 vaccines.

Sci Rep

2023 Jun 6

Farghaly HM, Gomaa MM, Elgeldawi E

Throughout the pandemic era, COVID-19 was one of the remarkable unexpected situations over the past few years, but with the decentralization and globalization of efforts and knowledge, a successful vaccine-based control strategy was efficiently designed and applied worldwide. On the other hand, excused confusion and hesitation have widely impacted public health. This paper aims to reduce COVID-19 vaccine hesitancy taking into consideration the patient's medical history. The dataset used in this study is the Vaccine Adverse Event Reporting System (VAERS) dataset which was created as a corporation between the Food and Drug Administration (FDA) and Centers for Disease Control and Prevention (CDC) to gather reported side effects that may be caused by PFIEZER, JANSSEN, and MODERNA vaccines. In this paper, a Deep Learning (DL) model has been developed to identify the relationship between a certain type of COVID-19 vaccine (i.e. PFIEZER, JANSSEN, and MODERNA) and the adverse reactions that may occur in vaccinated patients. The adverse reactions under study are the recovery condition, possibility to be hospitalized, and death status. In the first phase of the proposed model, the dataset has been pre-proceesed, while in the second phase, the Pigeon swarm optimization algorithm is used to optimally select the most promising features that affect the performance of the proposed model. The patient's status after vaccination dataset is grouped into three target classes (Death, Hospitalized, and Recovered). In the third phase, Recurrent Neural Network (RNN) is implemented for both each vaccine type and each target class. The results show that the proposed model gives the highest accuracy scores which are 96.031% for the Death target class in the case of PFIEZER vaccination. While in JANSSEN vaccination, the Hospitalized target class has shown the highest performance with an accuracy of 94.7%. Finally, the model has the best performance for the Recovered target class in MODERNA vaccination with an accuracy of 97.794%. Based on the accuracy and the Wilcoxon Signed Rank test, we can conclude that the proposed model is promising for identifying the relationship between the side effects of COVID-19 vaccines and the patient's status after vaccination. The study displayed that certain side effects were increased in patients according to the type of COVID-19 vaccines. Side effects related to CNS and hemopoietic systems demonstrated high values in all studied COVID-19 vaccines. In the frame of precision medicine, these findings can support the medical staff to select the best COVID-19 vaccine based on the medical history of the patient.

204. Research on controlling gas overrun in a working face based on gob-side entry retaining by utilizing ventilation type "Y".

Sci Rep

2023 Jun 6

Zhou X(#), Jing Z(#), Li Y(#).

To determine the characteristics of air leakage concerning a "Y" type ventilation in gob-side entry retaining with roof cutting, pressure relief, and the law of a resulted gas accumulation (GA), research is conducted by employing the CFD simulation incorporated with the gauged parameters of working face (WF) mining to analyze the air leakage of "Y" type ventilation. For this purpose, the 1201 fully mechanized coal mining face in the south Wu mining location of the Daxing coal mine is taken as an illustrative example to study the air leakage in the "Y" type ventilation. So, the gas concentration (GC) issue surpassing the limit in the upper corner of the goaf was simulated. The results show that the goaf is formed into an open space when roof cutting and pressure relief technology along the goaf is implemented. The air pressure at the upper corner of the WF would be the lowest, which is only 1.12 Pa. The airflow of air leakage under a pressure difference would move from the gob-side entry retaining to the goaf. Moreover, the simulation of mine ventilation indicates that the volume of air leakage positively correlates with the length of gob-side entry retaining. When the WF is advanced 500 m ahead, the maximum volume of air leakage would reach 247 m3/min within the range of 500-1300 m, and then the rate of air leakage gradually would decrease. When the WF is advanced at 1300 m, the air leakage would become the smallest, which is 175 m3/min. When gas control is under consideration, the effect of gas extraction would be best with the buried pipe whose depth and diameter are set to 4.0 m and 400 mm, respectively. So, the GC in the upper corner would become 0.37%. After the high-level borehole with a 120 mm diameter is mined, the GC in the deep goaf decreased to 3.52%, and the GC at the upper corner became further reduced to 0.21%. While the high-level borehole gas is extracted by employing the extraction system of the high-concentration gas, the extraction system of low-concentration gas is utilized to extract the upper corner gas of the WF, thus, the problem of gas overrun was resolved satisfactorily. During the recovery period of the mining, the GC at each gauging point was less than 0.8%, which effectively guided the secure production in the Daxing coal mine and provided a theoretical foundation to control gas overrun during the mining process.

205. Phase holograms for the three-dimensional patterning of unconstrained microparticles.

Sci Rep

2023 Jun 6

Ghanem MA, Maxwell AD, Dalecki D

206. Characterization of two lytic bacteriophages, infecting Streptococcus bovis/equinus complex (SBSEC) from Korean ruminant.

Sci Rep

2023 Jun 5

Park SY(#), Kwon H(#), Kim SG

207. Effects of fishery complementary photovoltaic power plant on radiation, energy flux and driving forces under different synoptic conditions.

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2023 Jun 5

Li P, Gao X, Li Z

208. Blooming of a microbial community in an Ediacaran extreme volcanic lake system.

Sci Rep

2023 Jun 5

Chraiki I, Chi Fru E, Somogyi A

209. Direct biomolecule discrimination in mixed samples using nanogap-based single-molecule electrical measurement.

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2023 Jun 5

Ryu J, Komoto Y, Ohshiro T

210. The genetic and clinical characteristics of WFS1 related diabetes in Chinese early onset type 2 diabetes.

Sci Rep

2023 Jun 5

Li Y(#), Gong S(#), Li M(#)

211. A clustering-optimized segmentation algorithm and application on food quality detection.

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2023 Jun 5

Wu Q, Li P, Chen Z

212. A balanced communication-avoiding support vector machine decision tree method for smart intrusion detection systems.

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2023 Jun 5

Al-Saleh A.

213. The genetics of a "femaleness/maleness" score in cardiometabolic traits in the UK biobank.

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2023 Jun 5

Vosberg DE, Pausova Z, Paus T.

214. Optimizing upside variability and antifragility in renewable energy system design.

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2023 Jun 5

Coppitters D, Contino F.

215. Microwave-assisted biodiesel production using -SO(3)H functionalized heterogeneous catalyst derived from a lignin-rich biomass.

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2023 Jun 5

Yadav N, Yadav G, Ahmaruzzaman M.

216. Robust-stein estimator for overcoming outliers and multicollinearity.

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2023 Jun 5

Lukman AF, Farghali RA, Kibria BMG

217. Association between smoking and obstructive sleep apnea based on the STOP-Bang index.

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2023 Jun 5

Jang YS, Nerobkova N, Hurh K

218. Effects of modified sleeper stretch and modified cross-body stretch on upper limb functions and shoulder ROM in tennis players: a randomized trial.

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2023 Jun 5

D A, Sudhan M A, Chandran S

219. Impact of Covid-19 pandemic lockdown on the urban litter and clean environment index.

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2023 Jun 5

Darabi K, Hayati R, Morovati M

220. A generalised deep learning-based surrogate model for homogenisation utilising material property encoding and physics-based bounds.

Sci Rep

2023 Jun 5

Nakka R, Harursampath D, Ponnusami SA.

221. Acute exposure to organophosphorus pesticide metabolites compromises buffalo sperm function and impairs fertility.

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2023 Jun 5

Chhillar S(#), Batra V(#), Kumaresan A

222. Moderate temperature deposition of RF magnetron sputtered SnO(2)-based electron transporting layer for triple cation perovskite solar cells.

Sci Rep

2023 Jun 5

Zakaria Y(#), Aïssa B(#), Fix T

223. A spike in circulating cytokines TNF-α and TGF-β alters barrier function between vascular and musculoskeletal tissues.

Sci Rep

2023 Jun 5

Ngo L, Knothe Tate ML.

Molecular transport between the circulatory and musculoskeletal systems regulates articular joint physiology in health and disease. Osteoarthritis (OA) is a degenerative joint disease linked to systemic and local inflammation. Inflammatory events involve cytokines, which are secreted by cells of the immune system and modulate molecular transport across tissue interfaces (referred to as tight junction [TJ] barrier function). In a previous study from our group, OA knee joint tissues were shown to exhibit size separation of different sized molecules delivered as a single bolus to the heart (Ngo et al. in Sci. Rep. 8:10254, 2018). Here, in a follow up study of parallel design, we test the hypothesis that two common cytokines, with multifaceted roles in the etiology of osteoarthritis as well as immune state in general, modulate the barrier function properties of joint tissue interfaces. Specifically, we probe the effect of an acute cytokine increase (spike) on molecular transport within tissues and across tissue interfaces of the circulatory and musculoskeletal systems. A single bolus of fluorescent-tagged 70 kDa dextran, was delivered intracardially, either alone, or with either the pro-inflammatory cytokine TNF-α or the anti-inflammatory cytokine TGF-β, to skeletally mature (11 to 13-month-old) guinea pigs (Dunkin-Hartley, a spontaneous OA animal model). After five minutes' circulation, whole knee joints were serial sectioned and fluorescent block face cryo-imaged at near-single-cell resolution. The 70 kDa fluorescent-tagged tracer is analogous in size to albumin, the most prevalent blood transporter protein, and quantification of tracer fluorescence intensity gave a measure of tracer concentration. Within five minutes, a spike (acute doubling) in circulating cytokines TNF-α or TGF-β significantly disrupted barrier function between the circulatory and musculoskeletal systems, with barrier function essentially abrogated in the TNF-α group. In the entire volume of the joint (including all tissue compartments and the bounding musculature), tracer concentration was significantly decreased in the TGF-β- and TNF-α- compared to the control-group. These studies implicate inflammatory cytokines as gatekeepers for molecular passage within and between tissue compartments of our joints and may open new means to delay the onset and mitigate the progression of degenerative joint diseases such as OA, using pharmaceutical and/or physical measures.

224. Membrane protease prostasin promotes insulin secretion by regulating the epidermal growth factor receptor pathway.

Sci Rep

2023 Jun 5

Ishii T, Miyasato Y, Ichijo M

225. Value of [(18)F]FDG PET/CT radiomic parameters in the context of response to chemotherapy in advanced cervical cancer.

Sci Rep

2023 Jun 5

Burchardt E, Bos-Liedke A, Serkowska K

226. Impact and centrality of attention dysregulation on cognition, anxiety, and low mood in adolescents.

Sci Rep

2023 Jun 5

Roberts C, Sahakian BJ, Chen S

Functional impairments in cognition are frequently thought to be a feature of individuals with depression or anxiety. However, documented impairments are both broad and inconsistent, with little known about when they emerge, whether they are causes or effects of affective symptoms, or whether specific cognitive systems are implicated. Here, we show, in the adolescent ABCD cohort (N = 11,876), that attention dysregulation is a robust factor underlying wide-ranging cognitive task impairments seen in adolescents with moderate to severe anxiety or low mood. We stratified individuals high in DSM-oriented depression or anxiety symptomology, and low in attention deficit hyperactivity disorder (ADHD), as well as vice versa - demonstrating that those high in depression or anxiety dimensions but low in ADHD symptoms not only exhibited normal task performance across several commonly studied cognitive paradigms, but out-performed controls in several domains, as well as in those low in both dimensions. Similarly, we showed that there were no associations between psychopathological dimensions and performance on an extensive cognitive battery after controlling for attention dysregulation. Further, corroborating previous research, the co-occurrence of attention dysregulation was associated with a wide range of other adverse outcomes, psychopathological features, and executive functioning (EF) impairments. To assess how attention dysregulation relates to and generates diverse psychopathology, we performed confirmatory and exploratory network analysis with different analytic approaches using Gaussian Graphical Models and Directed Acyclic Graphs to examine interactions between ADHD, anxiety, low mood, oppositional defiant disorder (ODD), social relationships, and cognition. Confirmatory centrality analysis indicated that features of attention dysregulation were indeed central and robustly connected to a wide range of psychopathological traits across different categories, scales, and time points. Exploratory network analysis indicated potentially important bridging traits and socioenvironmental influences in the relationships between ADHD symptoms and mood/anxiety disorders. Trait perfectionism was uniquely associated with both better cognitive performance and broad psychopathological dimensions. This work suggests that attentional dysregulation may moderate the breadth of EF, fluid, and crystalized cognitive task outcomes seen in adolescents with anxiety and low mood, and may be central to disparate pathological features, and thus a target for attenuating wide-ranging negative developmental outcomes.

227. Insights into the photovoltaic properties of indium sulfide as an electron transport material in perovskite solar cells.

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2023 Jun 5

Dastan D, Mohammed MKA(#), Al-Mousoi AK(#)

228. Exercise reduces hyperlipidemia-induced cardiac damage in apolipoprotein E-deficient mice via its effects against inflammation and oxidative stress.

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2023 Jun 5

Pei Z(#), Ji J(#), Gao Y

229. Physics-assisted machine learning methods for predicting the splitting tensile strength of recycled aggregate concrete.

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2023 Jun 5

Liu J, Han X, Pan Y

230. Influence of inorganic and organic salts on the hydration mechanism of montmorillonite based on molecular simulation.

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2023 Jun 5

Yang L, Xiang B, Zhao H

231. Probing the structural, mechanical, phonon, thermal, and transport properties of magnetic halide perovskites XTiBr(3) (X = Rb, Cs) through ab-initio results.

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2023 Jun 5

Shivhare V, Khandy SA, Gupta DC.

232. Universal mtDNA fragment for Cervidae barcoding species identification using phylogeny and preliminary analysis of machine learning approach.

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2023 Jun 5

Filip E, Strzała T, Stępień E

233. The atmospheric relevance of primary alcohols and imidogen reactions.

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2023 Jun 5

Douroudgari H, Zarepour H, Vahedpour M

234. Oral micronized progesterone for perimenopausal night sweats and hot flushes a Phase III Canada-wide randomized placebo-controlled 4 month trial.

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2023 Jun 5

Prior JC, Cameron A, Fung M

235. Predictive analysis of metabolic syndrome based on 5-years continuous physical examination data.

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2023 Jun 5

Zou G, Zhong Q, OUYang P

236. Predicting health outcomes in dogs using insurance claims data.

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2023 Jun 5

Debes C, Wowra J, Manzoor S

237. The impact of vitamin D3 supplementation on the faecal and oral microbiome of dairy calves indoors or at pasture.

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2023 Jun 5

Vigors S, Flores-Villalva S, Meade KG.

Vitamin D (VitD) is emerging as an immune regulator in addition to its established role in metabolism and mineral homeostasis. This study sought to determine if in vivo VitD modulated the oral and faecal microbiome in Holstein-Friesian dairy calves. The experimental model consisted of two control groups (Ctl-In, Ctl-Out) which were fed with a diet containing 6000 IU/Kg of VitD3 in milk replacer and 2000 IU/Kg in feed, and two treatment groups (VitD-In, VitD-Out) with 10,000 IU/Kg of VitD3 in milk replacer and 4000 IU/Kg in feed. One control and one treatment group were moved outdoors post-weaning at approximately 10 weeks of age. Saliva and faecal samples were collected after 7 months of supplementation and analysis of the microbiome was performed using 16S rRNA sequencing. Bray-Curtis dissimilarity analysis identified that both sampling site (oral vs. faecal) and housing (indoor vs. outdoor) had significant influences on the composition of the microbiome. The calves housed outdoors had greater microbial diversity in the faecal samples based on Observed, Chao1, Shannon, Simpson and Fisher measures in comparison to calves housed indoors (P < 0.05). A significant interaction between housing and treatment was observed for the genera Oscillospira, Ruminococcus, CF231 and Paludibacter in faecal samples. The genera Oscillospira and Dorea were increased while Clostridium and Blautia were decreased following VitD supplementation in the faecal samples (P < 0.05). An interaction between VitD supplementation and housing was detected in the abundance of the genera Actinobacillus and Streptococcus in the oral samples. VitD supplementation increased the genera Oscillospira, Helcococcus and reduced the genera Actinobacillus, Ruminococcus, Moraxella, Clostridium, Prevotella, Succinivibrio and Parvimonas. These preliminary data suggest that VitD supplementation alters both the oral and faecal microbiome. Further research will now be conducted to establish the significance of microbial alterations for animal health and performance.

238. Colossal figure of merit and compelling HER catalytic activity of holey graphyne.

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2023 Jun 5

Sajjad M(#), Nair SS(#), Samad YA

239. The capacity of action observation to drag the trainees' motor pattern toward the observed model.

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2023 Jun 5

Bazzini MC, Nuara A, Branchini G

240. FDM data driven U-Net as a 2D Laplace PINN solver.

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2023 Jun 5

Maria Antony AN, Narisetti N, Gladilin E.

241. In vivo toxicity evaluation of a polyoxotungstate nanocluster as a promising contrast agent for computed tomography.

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2023 Jun 5

Stojanović M(#), Lalatović J(#), Milosavljević A

242. SSMD-UNet: semi-supervised multi-task decoders network for diabetic retinopathy segmentation.

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2023 Jun 5

Ullah Z, Usman M, Latif S

243. Ecological risk assessment of aquatic organisms induced by heavy metals in the estuarine waters of the Pearl River.

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2023 Jun 5

Tang Z, Liu X, Niu X

244. Immunogenic cell death-related classifications guide prognosis and immunotherapy in osteosarcoma.

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2023 Jun 5

Zong Y, Cao Y, Zhang D

245. Association between marital status and all-cause mortality of patients with metastatic breast cancer: a population-based study.

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2023 Jun 5

Zhu S, Lei C.

This study aimed to investigate the association between marital status and the prognosis of patients with metastatic breast cancer (MBC). Data of patients with MBC were obtained from the Surveillance, Epidemiology, and End Results (SEER) database. Patients were classified into married and unmarried groups. Kaplan-Meier analysis with the log-rank test was conducted to compare breast cancer-specific survival (BCSS) and overall survival (OS) between the groups. Univariable and multivariable Cox proportional models were used to determine whether marital status was independently associated with OS, and the Fine-Gray subdistribution hazard method was performed to determine whether marital status was independently associated with BCSS. In total, 16,513 patients with MBC were identified, including 8949 married (54.19%) and 7564 unmarried (45.81%) patients. The married patients were significantly younger [median age (interquartile range), 59.0 (50.0-68.0) vs. 63.0 (53.0-75.0); p < 0.001] and received more aggressive treatments, such as chemotherapy (p < 0.001) and surgery (p < 0.001), than the unmarried patients. Moreover, married patients had higher 5-year BCSS (42.64% vs. 33.17%, p < 0.0001) and OS (32.22% vs. 21.44%, p < 0.0001) rates. Multivariable analysis revealed that marital status was an independent prognostic factor, and married status was associated with a significant reduction in the risk of breast cancer-specific (sub-hazard ratio, 0.845; 95% confidence interval, 0.804-0.888; p < 0.001) and all-cause (hazard ratio, 0.810; 95% confidence interval, 0.777-0.844; p < 0.001) mortality. Unmarried patients had a 15.5% increased risk of breast cancer-specific mortality and a 19.0% increased risk of overall mortality compared with married patients with MBC. BCSS and OS were superior in married populations compared with unmarried populations in most subgroups. Marital status was an independent prognostic indicator for survival in patients with MBC and was associated with significant survival benefits.

246. An efficient protocol for the synthesis of pyridines and hydroquinolones using IRMOF-3/GO/CuFe(2)O(4) composite as a magnetically separable heterogeneous catalyst.

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2023 Jun 5

Ghasemzadeh MA, Mirhosseini-Eshkevari B, Dadashi J.

247. Improving deep learning model performance under parametric constraints for materials informatics applications.

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2023 Jun 5

Gupta V, Peltekian A, Liao WK

248. MTAP-ANRIL gene fusion promotes melanoma epithelial-mesenchymal transition-like process by activating the JNK and p38 signaling pathways.

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2023 Jun 5

Lin Z, Lei Y, Wen M

249. Association of trabecular meshwork height with steroid-induced ocular hypertension.

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2023 Jun 5

Cho WJ, Kim Y, Kim JD

250. The nut-and-bolt motion of a bacteriophage sliding along a bacterial flagellum: a complete hydrodynamics model.

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2023 Jun 5

Karabasov SA, Zaitsev MA, Nerukh DA.

251. Development and application of random forest regression soft sensor model for treating domestic wastewater in a sequencing batch reactor.

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2023 Jun 5

Cheng Q, Chunhong Z, Qianglin L.

252. The real bacterial filtration efficiency to evaluate the effective protection of facemasks used for the prevention of respiratory diseases.

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2023 Jun 5

Benito PJ, Gutiérrez Á, Rojo-Tirado MA.

253. An assessment of self-rated life satisfaction and its correlates with physical, mental and social health status among older adults in India.

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2023 Jun 5

Bramhankar M, Kundu S, Pandey M

Life satisfaction refers to the assessment of one's own life in terms of self-perceived favourable qualities. It is an integral part of healthy and successful course of ageing. It is widely associated with the health status and social well-being. The present study attempted to determine the constructing factors of self-rated life satisfaction, such as socio-demographic, physical, social, and mental well-being of older adults. We analysed information from the Longitudinal Ageing Study in India (LASI-1), the initial phase conducted during 2017-18 for the population of older adults in India. We applied descriptive statistics for prevalence assessment and association was checked using chi-square test. Further, to determine the adjusted outcome of predictor covariates on the likelihood of an individual being satisfied from life estimated by applying hierarchical multiple logistic regression models. Several noteworthy affirmations on the relationship between the socio-demographic variables and health risk behaviours with life satisfaction were observed. The results were consistent with studies showing change in life satisfaction subject to the state of physical and mental health, presence of chronic diseases, friends and family relations, dependency, and events of trauma or abuse. While comparing respondents, we found varying degrees of life satisfaction by gender, education, marital status, expenditure and other socio-economic features. We also found that besides physical and mental health, social support and well-being play a pivotal role in achieving higher life satisfaction among older adults. Overall, this work contributes to the study of the subjective well-being of older adults in India based on self-reported levels of life satisfaction and further narrows the gap in knowledge about associated behaviour. Hence, with on-going ageing scenario, there is need for multi-sectorial policy-oriented approaches at individual, family, and community level, which helps to take care of older-adults' physical, social, and mental health for the betterment of healthy ageing.

254. The dynamics of telomere length in primary and metastatic colorectal cancer lesions.

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2023 Jun 5

Kroupa M, Kubecek O, Tomasova K

255. The relationships between microbiome diversity and epidemiology in domestic species of malaria-mediated mosquitoes of Korea.

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2023 Jun 5

Lee JH, Kim HW, Mustafa B

256. Dynamic computed tomography manifestations of simulated wooden foreign bodies in blood-saline mixtures with variable concentrations and retention times.

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2023 Jun 5

Zhu D, Li X, Zhao H

257. Genetically predicted circulating serum homocysteine levels on osteoporosis: a two-sample mendelian randomization study.

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2023 Jun 4

Wang C, Zhang X, Qiu B.

258. AMST(2): aggregated multi-level spatial and temporal context-based transformer for robust aerial tracking.

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2023 Jun 4

Park H, Lee I, Jeong D

259. A novel scale based on biomarkers associated with COVID-19 severity can predict the need for hospitalization and intensive care, as well as enhanced probabilities for mortality.

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2023 Jun 4

Nieto-Ortega E(#), Maldonado-Del-Arenal A(#), Escudero-Roque L(#)

260. A method for modelling polymer electrolyte decomposition during the Li-nucleation process in Li-metal batteries.

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2023 Jun 4

Wu LT, Andersson EKW, Hahlin M

261. Prognostic value of coronary CTA-based classifications for predicting major events without obstructive coronary artery disease.

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2023 Jun 30

Huang Z(#), Cao B(#), Du X(#)

262. The effects of IL-1β stimulated human umbilical cord mesenchymal stem cells on polarization and apoptosis of macrophages in rheumatoid arthritis.

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2023 Jun 30

Zeng YX, Chou KY, Hwang JJ

263. Three fourths of women of reproductive age in emerging regions of Ethiopia are facing problems in accessing health care.

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2023 Jun 30

Fetene SM, Haile TG.

Providing adequate and equal access health care is a key goal towards universal health coverage (UHC), but women continue to confront considerable inequities in accessing healthcare, particularly in the emerging regions of Ethiopia. Therefore, we identified the contributing factors to the problems in accessing health care among women of reproductive age in emerging regions of Ethiopia. Data from the 2016 Ethiopia Demographic and Health Survey were used. A total of 4680 women in reproductive age were included in the final analysis and a multilevel mixed-effect binary logistic regression analysis was done to identify the contributing factors to the problems in accessing health care. In the final model, a p-value of less than 0.05 and adjusted odds ratio (AOR) with 95% confidence interval (CI) were used to declare statistically significant factors. We found that 71.0% (95% CI 69.64-72.24%) of women in reproductive age had problems in accessing health care. Unmarried women (AOR = 1.30 95% CI 1.06-1.59), uneducated (AOR = 2.21 95% CI 1.48-3.30) and attended primary school (AOR = 1.58 95% 1.07-2.32), rural resident (AOR = 2.16 95% CI 1.40-2.02), poor (AOR = 2.95 95% CI 2.25-3.86) and middle wealth status (AOR = 1.74 95% CI 1.27-2.40), women who gave two births (AOR = 1.29 95% CI: 1.02-1.64) and not working (AOR = 1.33 95% CI 1.06, - 1.68) and working in agriculture (AOR = 1.88 95% CI 1.35-2.61) were factors that contributed for the problems in accessing health care. A significant proportion of women of reproductive age in emerging regions of Ethiopia face challenges in accessing healthcare, which places the country far from achieving its UHC targets. This issue is particularly prominent among unmarried, poor and middle wealth status, uneducated, non-working, and rural women of reproductive age. The government should develop strategies to improve women's education, household wealth status, and occupational opportunities which would help to alleviate the barriers hindering healthcare access for women residing in emerging regions of Ethiopia.

264. Functional outcome in patients with traumatic or hemorrhagic brain injuries undergoing decompressive craniectomy versus craniotomy and 6-month rehabilitation.

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2023 Jun 30

Pingue V, Franciotta D.

Decompressive craniectomy (DC) and craniotomy (CT) to treat increased intracranial pressure after brain injury are common but controversial choices in clinical practice. Studying a large cohort of patients with traumatic brain injury (TBI) and hemorrhagic stroke (HS) on rehabilitation pathways, we aimed to determine the impact of DC and CT on functional outcome/mortality, and on seizures occurrence. This observational retrospective study included patients with either TBI, or HS, who underwent DC or CT, consecutively admitted to our unit for 6-month neurorehabilitation programs between January 1, 2009 and December 31, 2018. Neurological status using Glasgow Coma Scale (GCS), and rehabilitation outcome with Functional Independence Measure, both assessed at baseline and on discharge, post-DC cranioplasty, prophylactic antiepileptic drug use, occurrence of early/late seizures, infectious complications, and death during hospitalization were evaluated and analyzed with linear and logistic regression models. Among 278 patients, DC was performed in 98 (66.2%) with HS, and in 98 (75.4%) with TBI, whilst CT in 50 (33.8%) with HS, and in 32 (24.6%) with TBI. On admission, GCS scores were lower in patients treated with CT than in those with DC (HS, p = 0.016; TBI, p = 0.024). Severity of brain injury and older age were the main factors affecting functional outcome, without between-group differences, but DC associated with worse functional outcome, independently from severity or type of brain injury. Unprovoked seizures occurred post-DC cranioplasty more frequently after HS (OR = 5.142, 95% CI 1.026-25.784, p = 0.047). DC and CT shared similar risk of mortality, which associated with sepsis (OR = 16.846, 95% CI 5.663-50.109, p < 0.0001), or acute symptomatic seizures (OR = 4.282, 95% CI 1.276-14.370, p = 0.019), independently from the neurosurgery procedures. Among CT and DC, the latter neurosurgical procedure is at major risk of worse functional outcome in patients with mild-to-severe TBI, or HS undergoing an intensive rehabilitation program. Complications with sepsis or acute symptomatic seizures increase the risk of death.

265. Spatio-temporal modelling of routine health facility data for malaria risk micro-stratification in mainland Tanzania.

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2023 Jun 30

Thawer SG, Golumbeanu M, Lazaro S

266. Dim artificial light at night alters gene expression rhythms and growth in a key seagrass species (Posidonia oceanica).

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2023 Jun 30

Dalle Carbonare L, Basile A, Rindi L

Artificial light at night (ALAN) is a globally spreading anthropogenic stressor, affecting more than 20% of coastal habitats. The alteration of the natural light/darkness cycle is expected to impact the physiology of organisms by acting on the complex circuits termed as circadian rhythms. Our understanding of the impact of ALAN on marine organisms is lagging behind that of terrestrial ones, and effects on marine primary producers are almost unexplored. Here, we investigated the molecular and physiological response of the Mediterranean seagrass, Posidonia oceanica (L.) Delile, as model to evaluate the effect of ALAN on seagrass populations established in shallow waters, by taking advantage of a decreasing gradient of dim nocturnal light intensity (from < 0.01 to 4 lx) along the NW Mediterranean coastline. We first monitored the fluctuations of putative circadian-clock genes over a period of 24 h along the ALAN gradient. We then investigated whether key physiological processes, known to be synchronized with day length by the circadian rhythm, were also affected by ALAN. ALAN influenced the light signalling at dusk/night in P. oceanica, including that of shorter blue wavelengths, through the ELF3-LUX1-ZTL regulatory network, and suggested that the daily perturbation of internal clock orthologs in seagrass might have caused the recruitment of PoSEND33 and PoPSBS genes to mitigate the repercussions of a nocturnal stress on photosynthesis during the day. A long-lasting impairment of gene fluctuations in sites characterised by ALAN could explain the reduced growth of the seagrass leaves when these were transferred into controlled conditions and without lighting during the night. Our results highlight the potential contribution of ALAN to the global loss of seagrass meadows, posing questions about key interactions with a variety of other human-related stressors in urban areas, in order to develop more efficient strategies to globally preserve these coastal foundation species.

267. Small RNA sequencing of field Culex mosquitoes identifies patterns of viral infection and the mosquito immune response.

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2023 Jun 30

Abel SM(#), Hong Z(#), Williams D

268. Multi-objective pathfinder algorithm for multi-objective optimal power flow problem with random renewable energy sources: wind, photovoltaic and tidal.

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2023 Jun 30

Li N, Zhou G, Zhou Y

269. Identification of early stage and metastatic prostate cancer using electrochemical detection of beta-2-microglobulin in urine samples from patients.

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2023 Jun 30

Nasimi H, Madsen JS, Zedan AH

270. Alterations in choroidal vascular structures due to serum levels of vascular endothelial growth factor in patients with POEMS syndrome.

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2023 Jun 30

Yokouchi H, Nagasato D, Mitamura Y

271. Foraging for selenium: a comparison between hyperaccumulator and non-accumulator plant species.

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2023 Jun 30

Montanari S(#), Salinitro M(#), Simoni A

272. White matter hyperintensities associated with impulse control disorders in Parkinson's Disease.

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2023 Jun 30

Hernadi G(#), Perlaki G(#), Kovacs M

273. Application of structural equation modelling to inform best management strategies for Marek's disease in Amhara region, Ethiopia.

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2023 Jun 30

Birhan M, Berhane N, Ibrahim SM

274. Therapeutic effect of melatonin-loaded chitosan/lecithin nanoparticles on hyperglycemia and pancreatic beta cells regeneration in streptozotocin-induced diabetic rats.

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2023 Jun 30

Alaa H, Abdelaziz M, Mustafa M

275. Effectiveness of creating digital twins with different digital dentition models and cone-beam computed tomography.

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2023 Jun 30

Lee JH, Lee HL, Park IY

276. Computational model for lipid binding regions in phospholipase (Ves a 1) from Vespa venom.

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2023 Jun 30

Pattaranggoon NC, Daduang S, Rungrotmongkol T

277. Effects of propolis-loaded nanoliposomes fortification in extender on buffalo semen cryopreservation.

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2023 Jun 30

Abdelnour SA, Hassan MAE, Shehabeldin AM

Buffalo sperm is sensitive to cryoinjuries, thus improving sperm cryoresistance is a critical approach for wide spreading the assisted reproductive technologies in buffalo. The intention of this work was to assess the effect of propolis-loaded in nanoliposomes (PRNL) supplementation of semen extender on semen quality, antioxidant status and some apoptotic genes of cryopreserved buffalo semen. PRNL were prepared using cholesterol (Chol) as well as soybean lecithin and their physicochemical properties were characterized. Egyptian buffalo bulls (4-6 years) were involved, and the semen samples were collected using the artificial vagina method. Buffalo semen was pooled (n = 25 ejaculates) and cryopreserved in tris extender containing PRNL at 0 (PRNL0), 2 (PRNL2), 4 (PRNL4) and 6 µg/mL (PRNL6), respectively. The PRNL had a size of 113.13 nm and a negative zeta potential (- 56.83 mV). Sperm progressive motility, viability, membrane integrity, abnormalities, chromatin damage, redox status, apoptosis status, and apoptotic genes were investigated after post-thawed buffalo semen. Using 2 or 4 µg/mL PRNL significantly increased sperm progressive motility, viability, and membrane integrity, while sperm abnormalities and the percentage of chromatin damages were the lowest in PRNL2 group. Moreover, the PRNL2 group exhibited the best results for all antioxidative activities (TAC, SOD, GPx and CAT) with significantly higher levels than the other groups (P < 0.05). The levels of ROS and MDA were significantly lower in the PRLN2 compared with other groups. The sperm caspase 3 enzyme activities showed the lowest values in PRNL2 groups followed by PRNL4 and PRNL6 groups with significant differences compared with the control. Adding 2 µg/mL PRNL to freezing media significantly reduced apoptotic genes such as Bax and Caspase 3 in sperm, while significantly increase in Bcl2 expression compared with the control (P < 0.001). The expression of Bcl2, Caspase 3 and Bax genes in sperm were not affected by the 6 µg/mL PRNL addition (P > 0.05). The electron micrography descriptions exemplified that the fortification of 2 or 4 µg/mL PRNL maintained the acrosomal and plasma membrane integrities as well as sustained the ultrastructure integrity of the cryopreserved buffalo spermatozoa when compared with control group, whereas the 6 µg/mL of PRNL demonstrated highest injury to the acrosome and plasma membranes. Results show supplementation of the buffalo freezing extender with 2 or 4 µg/mL of PRNL enhanced post-thawed sperm quality via boosting the antioxidant indices, diminishing the oxidative stress and apoptosis as well as maintained the ultrastructure integrity of frozen-thawed buffalo sperm.

278. Growth, allergen profile and microbiome studies in Dermatophagoides pteronyssinus cultures.

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2023 Jun 30

Calzada D, Martín-López L, Carnés J.

279. Physicochemical features partially explain olfactory crossmodal correspondences.

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2023 Jun 30

Ward RJ, Wuerger SM, Ashraf M

280. MDTOMO method for continuous conformational variability analysis in cryo electron subtomograms based on molecular dynamics simulations.

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2023 Jun 30

Vuillemot R, Rouiller I, Jonić S.

281. Disparate dynamics of pathogen prevalence in Ixodes ricinus and Dermacentor reticulatus ticks occurring sympatrically in diverse habitats.

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2023 Jun 30

Zając Z, Obregon D, Foucault-Simonin A

282. Pure edge-contact devices on single-layer-CVD-graphene integrated into a single chip.

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2023 Jun 30

Behera S.

283. Adsorption and reversible conformational change of a thiophene based molecule on Au(111).

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2023 Jun 30

Sarkar S, Au-Yeung KH, Kühne T

284. Wound healing responses of urinary extravasation after urethral injury.

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2023 Jun 30

Hyuga T, Fujimoto K, Hashimoto D

285. Green solvent mediated extraction of micro- and nano-plastic particles from water.

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2023 Jun 30

Hunter JR, Qiao Q, Zhang Y

286. Effect of nutrition intervention on cognitive development among malnourished preschool children: randomized controlled trial.

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2023 Jun 30

Ansuya, Nayak BS, Unnikrishnan B

287. Assessing physical abilities of sarcopenia patients using gait analysis and smart insole for development of digital biomarker.

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2023 Jun 30

Kim S, Park S, Lee S

288. Molecular and biological activities of metal oxide-modified bioactive glass.

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2023 Jun 30

Tiama TM, Elhaes H, Ibrahim MA

289. Controlled viscous fingering in volatile fluid towards spontaneous evolution of ordered 3D patterns.

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2023 Jun 30

Rakshe MA, Gandhi PS.

290. Micro-architecture design exploration template for AutoML case study on SqueezeSEMAuto.

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2023 Jun 30

Chantrapornchai C, Kajkamhaeng S, Romphet P.

291. Spatial distribution, sources and health risk assessment of heavy metals in topsoil around oil and natural gas drilling sites, Andhra Pradesh, India.

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2023 Jun 30

Aradhi KK, Dasari BM, Banothu D

292. Advanced characterization-informed machine learning framework and quantitative insight to irradiated annular U-10Zr metallic fuels.

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2023 Jun 30

Xu F(#), Cai L(#), Salvato D

293. Videos posted on the internet provide evidence for joint rushing in naturalistic social interactions.

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2023 Jun 30

Wolf T, Novák T, Knoblich G.

294. The concentration of particulate matter in the barn air and its influence on the content of heavy metals in milk.

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2023 Jun 30

Nieckarz Z, Pawlak K, Baran A

295. Experimental insights into energy savings and future directions of drag reducing polymers in multiphase flow pipelines.

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2023 Jun 30

Alsurakji IH, Al-Sarkhi A, El-Qanni A

Frictional pressure drop has been grasping the attention of many industrial applications associated with multi-phase and academia. Alongside the United Nations, the 2030 Agenda for Sustainable Development calls for the exigency of giving attention to economic growth, a considerable reduction in power consumption is necessary to co-up with this vision and to adhere to energy-efficient practices. Thereinto, drag-reducing polymers (DRPs), which do not require additional infrastructure, are a much better option for increasing energy efficiency in a series of critical industrial applications. Therefore, this study evaluates the effects of two DRPs-polar water-soluble polyacrylamide (DRP-WS) and nonpolar oil-soluble polyisobutylene (DRP-OS)-on energy efficiency for single-phase water and oil flows, two-phase air-water and air-oil flows, and three-phase air-oil-water flow. The experiments were conducted using two different pipelines; horizontal polyvinyl chloride with an inner diameter of 22.5 mm and horizontal stainless steel with a 10.16 mm internal diameter. The energy-efficiency metrics are performed by investigating the head loss, percentage saving in energy consumption (both per unit pipe length), and throughput improvement percentage (%TI). The larger pipe diameter was used in experiments for both DRPs, and it was discovered that despite the type of flow or variations in liquid and air flow rates, there was a reduction in head loss, an increase in energy savings, and an increase in the throughput improvement percentage. In particular, DRP-WS is found to be more promising as an energy saver and the consequent savings in the infrastructure cost. Hence, equivalent experiments of DRP-WS in two-phase air-water flow using a smaller pipe diameter show that the head loss drastically increases. However, the percentage saving in power consumption and throughput improvement percentage is significantly compared with that found in the larger pipe. Thus, this study found that DRPs can improve energy efficiency in various industrial applications, with DRP-WS being particularly promising as an energy saver. However, the effectiveness of these polymers may vary depending on the flow type and pipe diameter.

296. Integration of force and IMU sensors for developing low-cost portable gait measurement system in lower extremities.

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2023 Jun 30

Manupibul U, Tanthuwapathom R, Jarumethitanont W

297. ConvNeXt steel slag sand substitution rate detection method incorporating attention mechanism.

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2023 Jun 30

Teng S, Zhu L, Li Y

298. The impact of bilateral anodal transcranial direct current stimulation of the premotor and cerebellar cortices on physiological and performance parameters of gymnastic athletes: a randomized, cross-over, sham-controlled study.

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2023 Jun 30

Anoushiravani S, Alizadehgoradel J, Iranpour A

Professional sports performance relies critically on the interaction between the brain and muscles during movement. Transcranial direct current stimulation (tDCS) is a noninvasive brain stimulation technique which modulates cortical excitability and can be used to improve motor performance in athletes. The present study aimed to investigate the effect of bilateral anodal tDCS (2 mA, 20 min) over the premotor cortex or cerebellum on motor and physiological functions and peak performance of professional gymnastics athletes. Seventeen professional gymnastics athletes participated in a randomized, sham-controlled, crossover study. In this study, we assessed the efficacy of two anodal tDCS protocols (2 mA, 20 min) with stimulation over the bilateral premotor cortex or cerebellum with the return electrodes placed over the opposite supraorbital areas. Power speed, strength coordination, endurance, static and dynamic strength, static and dynamic flexibility, and rating of perceived exertion were measured before and immediately after tDCS interventions (bilateral anodal tDCS over premotor cortices, anodal tDCS over the cerebellum, and sham tDCS). Additionally, physiological muscle performance parameters, including maximum voluntary isometric contraction (MVIC) of upper body muscles, were assessed during tDCS. Bilateral anodal tDCS over the premotor cortex, compared to anodal tDCS over the cerebellum and sham tDCS conditions, significantly improved power speed, strength coordination, and static and dynamic strength variables of professional gymnastics athletes. Furthermore, bilateral anodal tDCS over the cerebellum, compared to sham tDCS, significantly improved strength coordination. Moreover, bilateral premotor anodal tDCS significantly increased MVIC of all upper body muscles during stimulation, while anodal tDCS over the cerebellum increased MVIC in only some muscles. Bilateral anodal tDCS over the premotor cortex, and to a minor degree over the cerebellum, might be suited to improve some aspects of motor and physiological functions and peak performance levels of professional gymnastics athletes.Clinical Trial Registration ID: IRCT20180724040579N2.

299. Long-term surveillance provides real-world evidences of safety and effectiveness in intravitreal aflibercept treatment for age-related macular degeneration.

Sci Rep

2023 Jun 30

Ozawa Y, Ohgami K, Sasaki K

300. The TNFR1 antagonist Atrosimab reduces neuronal loss, glial activation and memory deficits in an acute mouse model of neurodegeneration.

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2023 Jun 30

Ortí-Casañ N(#), Boerema AS(#), Köpke K

301. Diurnal change of retinal vessel density related to hemodynamic variation in treatment-naïve low-teens normal-tension glaucoma.

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2023 Jun 30

Baek SU, Kwon S, Kim YK

302. Seasonal prevalence of bacteria in the outflow of two full-scale municipal wastewater treatment plants.

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2023 Jun 30

Domańska M, Kuśnierz M, Mackiewicz K.

Despite many modern wastewater treatment solutions, the most common is still the use of activated sludge (AS). Studies indicate that the microbial composition of AS is most often influenced by the raw sewage composition (especially influent ammonia), biological oxygen demand, the level of dissolved oxygen, technological solutions, as well as the temperature of wastewater related to seasonality. The available literature mainly refers to the relationship between AS parameters or the technology used and the composition of microorganisms in AS. However, there is a lack of data on the groups of microorganisms leaching into water bodies whose presence is a signal for possible changes in treatment technology. Moreover, sludge flocs in the outflow contain less extracellular substance (EPS) which interferes microbial identification. The novelty of this article concerns the identification and quantification of microorganisms in the AS and in the outflow by fluorescence in situ hybridization (FISH) method from two full-scale wastewater treatment plants (WWTPs) in terms of 4 key groups of microorganisms involved in the wastewater treatment process in the context of their potential technological usefulness. The results of the study showed that Nitrospirae, Chloroflexi and Ca. Accumulibacter phosphatis in treated wastewater reflect the trend in abundance of these bacteria in activated sludge. Increased abundance of betaproteobacterial ammonia-oxidizing bacteria and Nitrospirae in the outflow were observed in winter. Principal component analysis (PCA) showed that loadings obtained from abundance of bacteria in the outflow made larger contributions to the variance in the PC1 factorial axis, than loadings obtained from abundance of bacteria from activated sludge. PCA confirmed the reasonableness of conducting studies not only in the activated sludge, but also in the outflow to find correlations between technological problems and qualitative and quantitative changes in the outflow microorganisms.

303. A neonicotinoid pesticide alters Drosophila olfactory processing.

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2023 Jun 30

Tatarko AR, Leonard AS, Mathew D.

304. Color multilayer holographic near-eye augmented reality display.

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2023 Jun 30

Velez-Zea A, Barrera-Ramírez JF.

305. Liver transplantation for intrahepatic cholangiocarcinoma: a propensity score-matched analysis.

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2023 Jun 30

Huang G, Song W, Zhang Y

306. Connectivity alteration in thalamic nuclei and default mode network-related area in memory processes in mesial temporal lobe epilepsy using magnetoencephalography.

Sci Rep

2023 Jun 30

Ishizaki T, Maesawa S, Nakatsubo D

307. Fluorescence intensity and fluorescence lifetime measurements of various carbon dots as a function of pH.

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2023 Jun 30

Szapoczka WK, Truskewycz AL, Skodvin T

308. Lipoxygenase inhibitory synthetic derivatives of methyl gallate regulate gene expressions of COX-2 and cytokines to reduce animal model arthritis.

Sci Rep

2023 Jun 30

Sharanya CS, Abhithaj J, Arun KG

Mammalian lipoxygenases (LOXs) are involved in the biosynthesis of mediators of anaphylactic reactions and have been implicated in cell maturation, the pathogenesis of bronchial asthma, atherosclerosis, rheumatoid arthritis, cardiovascular diseases, Alzheimer's disease and osteoporosis. Hence LOX inhibition in chronic conditions can lead to reducing the disease progression, which can be a good target for treating these diseases. The present study deals with designing methyl gallate derivatives and their anti-inflammatory effect by in silico, in vitro and in vivo methods. Designed derivatives were docked against LOX enzyme, and molecular dynamic simulations were carried out. Following the synthesis of derivatives, in vitro LOX inhibition assay, enzyme kinetics and fluorescence quenching studies were performed. One of the derivatives of methyl gallate (MGSD 1) was demonstrated as an anti-inflammatory agent for the treatment of rheumatoid arthritis in the animal model. Amelioration of Freund's complete adjuvant (FCA)-induced arthritis by methyl gallate and its derivative with a concentration of 10-40 mg.kg-1 has been assessed in vivo in a 28-day-long study. TNF-α and COX-2 gene expression were also studied. Methyl gallate synthetic derivatives (MGSDs) inhibited LOX with an IC50 of 100 nM, 304 nM, and 226 nM for MGSD 1, MGSD 2, and MGSD 3, respectively. Fluorescence quenching methods also prove their binding characteristics, and 200 ns simulations studies showed that the RMSDs for the entire complex were less than 2.8 Å. The in vivo results showed that methyl gallate was required approximately five times diclofenac for the same level of effect, and the synthesised (MGSD 1) compound required only approximately 1/12 of diclofenac for the same level of effect in in-vivo studies. The preeminent expression of COX-2 and TNF-α genes was significantly decreased after the treatment of the methyl gallate derivative. Hence, the in vivo results showed that the referenced synthetic derivative might have more arthritis-reducing properties than the parent compound methyl gallate and is more potent than the standard drug diclofenac, with no apparent induced toxicity.

309. Gold conjugated nanobodies in a signal-enhanced lateral flow test strip for rapid detection of SARS-CoV-2 S1 antigen in saliva samples.

Sci Rep

2023 Jun 30

Maher S, Kamel M, Demerdash Z

310. High Chern numbers in a perovskite-derived dice lattice (LaXO(3))(3)/(LaAlO(3))(3)(111) with X = Ti, Mn and Co.

Sci Rep

2023 Jun 30

Köksal O, Li LL, Pentcheva R.

311. An investigation of simulated and real touch on feelings of loneliness.

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2023 Jun 30

Gray NLT, Roberts SC.

312. Micro mercury trapped ion clock prototypes with 10[Formula: see text] frequency stability in 1-liter packages.

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2023 Jun 30

Hoang TM, Chung SK, Le T

313. Optimized production, purification, and radiolabeling of the (203)Pb/(212)Pb theranostic pair for nuclear medicine.

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2023 Jun 30

McNeil BL, Mastroianni SA, McNeil SW

314. Disabled and Romani passengers face similar levels of discrimination but different levels of open hostility in the sharing economy.

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2023 Jun 30

Simonovits B, Kurdi B, Simonovits G.

315. Generalized neural closure models with interpretability.

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2023 Jun 30

Gupta A, Lermusiaux PFJ.

Improving the predictive capability and computational cost of dynamical models is often at the heart of augmenting computational physics with machine learning (ML). However, most learning results are limited in interpretability and generalization over different computational grid resolutions, initial and boundary conditions, domain geometries, and physical or problem-specific parameters. In the present study, we simultaneously address all these challenges by developing the novel and versatile methodology of unified neural partial delay differential equations. We augment existing/low-fidelity dynamical models directly in their partial differential equation (PDE) forms with both Markovian and non-Markovian neural network (NN) closure parameterizations. The melding of the existing models with NNs in the continuous spatiotemporal space followed by numerical discretization automatically allows for the desired generalizability. The Markovian term is designed to enable extraction of its analytical form and thus provides interpretability. The non-Markovian terms allow accounting for inherently missing time delays needed to represent the real world. Our flexible modeling framework provides full autonomy for the design of the unknown closure terms such as using any linear-, shallow-, or deep-NN architectures, selecting the span of the input function libraries, and using either or both Markovian and non-Markovian closure terms, all in accord with prior knowledge. We obtain adjoint PDEs in the continuous form, thus enabling direct implementation across differentiable and non-differentiable computational physics codes, different ML frameworks, and treatment of nonuniformly-spaced spatiotemporal training data. We demonstrate the new generalized neural closure models (gnCMs) framework using four sets of experiments based on advecting nonlinear waves, shocks, and ocean acidification models. Our learned gnCMs discover missing physics, find leading numerical error terms, discriminate among candidate functional forms in an interpretable fashion, achieve generalization, and compensate for the lack of complexity in simpler models. Finally, we analyze the computational advantages of our new framework.

316. A validated test has been developed for assessment of manual small incision cataract surgery skills using virtual reality simulation.

Sci Rep

2023 Jun 30

Hutter DE, Wingsted L, Cejvanovic S

317. Tocilizumab-induced hypofibrinogenemia in patients with systemic-onset juvenile idiopathic arthritis.

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2023 Jun 3

He T(#), Ling J(#), Yang J.

Systemic juvenile idiopathic arthritis (SJIA) is a chronic inflammatory disease of childhood with elevated serum IL-6 levels. As an inhibitor of IL-6R, tocilizumab (TCZ) has been approved to treat SJIA patients. TCZ-induced hypofibrinogenemia has been only reported in adult cases and limited small case series with rheumatoid arthritis or giant cell arteritis. Here, we describe the incidence of TCZ-induced hypofibrinogenemia in SJIA patients and its possible influence on bleeding risk. SJIA patients with TCZ treatment in Shenzhen Children's hospital were retrospectively reviewed. Only those with the data on serum fibrinogen levels were included. Data on clinical manifestations, laboratory parameters, management, and sJADAS10-ESR score were collected. Laboratory data were extracted following the start of TCZ therapy at 2, 4, 8, 12, and 24 weeks thereafter. Seventeen SJIA patients with TCZ treatment were included. Thirteen (76.47%, 13/17) had hypofibrinogenemia. The lowest serum fibrinogen levels were even below 1.5 g/L in seven (41.17%, 7/17) patients. Among four patients without MTX treatment, two had obvious hypofibrinogenemia. Although five patients had already stopped steroid treatment 24 weeks after TCZ treatment, three of them still had hypofibrinogenemia. Only P14 had mild nasal mucosal bleeding occasionally. Coagulation tests were regularly performed in eight patients, of these, six had hypofibrinogenemia, which occurred following one to four doses of TCZ; continuation of TCZ treatment hadn't further aggravated hypofibrinogenemia. Serum fibrinogen levels were not decreased consistently with the improvement of sJADAS10-ESR score in more than half of these eight patients. Factor XIII was detected in six patients and none was identified with Factor XIII deficiency. TCZ alone may induce hypofibrinogenemia in SJIA patients. Continuation of TCZ treatment may be safe for most SJIA patients. But for SJIA patients with indications of surgery or complicated with MAS, the risk of hemorrhage should be regularly evaluated during TCZ treatment. The association between TCZ-induced hypofibrinogenemia and factor XIII deficiency remains uncertain.Trial registration: Not applicable; this was a retrospective study.

318. Establishment of cancer-associated fibroblasts-related subtypes and prognostic index for prostate cancer through single-cell and bulk RNA transcriptome.

Sci Rep

2023 Jun 3

Qian Y(#), Feng D(#), Wang J(#)

319. Construction and characterization of nano-oval BaTi(0.7)Fe(0.3)O(3)@NiFe(2)O(4) nanocomposites as an effective platform for the determination of H(2)O(2).

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2023 Jun 3

Hammad ABA, Magar HS, Mansour AM

Talented di-phase ferrite/ferroelectric BaTi0.7Fe0.3O3@NiFe2O4 (BFT@NFO) in oval nano-morphology was chemically synthesized using controlled sol-gel processes and calcined at 600 °C. The effects of shielding using NiFe2O4 (NFO) nanoparticles on the microstructure, phase transition, thermal, and relative permittivity of BaTi0.7Fe0.3O3 (BTF) nano-perovskite were systematically explored. X-ray diffraction patterns and Full-Prof software exhibited the forming of the BaTi2Fe4O11 hexagonal phase. TEM and SEM images demonstrated that the coating of BaTi0.7Fe0.3O3 has been successfully controlled with exquisite nano-oval NiFe2O4 shapes. The NFO shielding can significantly promote the thermal stability and the relative permittivity of BFT@NFO pero-magnetic nanocomposites and lowers the Curie temperature. Thermogravimetric and optical analysis were used to test the thermal stability and estimate the effective optical parameters. Magnetic studies showed a decrease in saturation magnetization of NiFe2O4 NPs compared to their bulk system, which is attributed to surface spin disorder. Herein, characterization and the sensitive electrochemical sensor were constructed for the evaluation of peroxide oxidation detection using the chemically adjusted nano-ovals barium titanate-iron@nickel ferrite nanocomposites. Finally, The BFT@NFO exhibited excellent electrochemical properties which can be ascribed to this compound possessing two electrochemical active components and/or the nano-ovals structure of the particles which can further improve the electrochemistry through the possible oxidation states and the synergistic effect. The result advocates that when the BTF is shielded with NFO nanoparticles the thermal, dielectric, and electrochemical properties of nano-oval BaTi0.7Fe0.3O3@NiFe2O4 nanocomposites can be synchronously developed. Thus, the production of ultrasensitive electrochemical nano-systems for the determination of hydrogen peroxide is of extensive significance.

320. Predicting U.S. county opioid poisoning mortality from multi-modal social media and psychological self-report data.

Sci Rep

2023 Jun 3

Giorgi S, Yaden DB, Eichstaedt JC

321. Model-based estimation of muscle and ACL forces during turning maneuvers in alpine skiing.

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2023 Jun 3

Heinrich D, van den Bogert AJ, Mössner M

In alpine skiing, estimation of the muscle forces and joint loads such as the forces in the ACL of the knee are essential to quantify the loading pattern of the skier during turning maneuvers. Since direct measurement of these forces is generally not feasible, non-invasive methods based on musculoskeletal modeling should be considered. In alpine skiing, however, muscle forces and ACL forces have not been analyzed during turning maneuvers due to the lack of three dimensional musculoskeletal models. In the present study, a three dimensional musculoskeletal skier model was successfully applied to track experimental data of a professional skier. During the turning maneuver, the primary activated muscles groups of the outside leg, bearing the highest loads, were the gluteus maximus, vastus lateralis as well as the medial and lateral hamstrings. The main function of these muscles was to generate the required hip extension and knee extension moments. The gluteus maximus was also the main contributor to the hip abduction moment when the hip was highly flexed. Furthermore, the lateral hamstrings and gluteus maximus contributed to the hip external rotation moment in addition to the quadratus femoris. Peak ACL forces reached 211 N on the outside leg with the main contribution in the frontal plane due to an external knee abduction moment. Sagittal plane contributions were low due to consistently high knee flexion (> 60[Formula: see text]), substantial co-activation of the hamstrings and the ground reaction force pushing the anteriorly inclined tibia backwards with respect to the femur. In conclusion, the present musculoskeletal simulation model provides a detailed insight into the loading of a skier during turning maneuvers that might be used to analyze appropriate training loads or injury risk factors such as the speed or turn radius of the skier, changes of the equipment or neuromuscular control parameters.

322. An assessment of nicotine pharmacokinetics and subjective effects of the pulze heated tobacco system compared with cigarettes.

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2023 Jun 3

McDermott S, Reichmann K, Mason E

323. A retrospect study based on real-world data to observe metabolic function in cancer patients using albumin-bound paclitaxel.

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2023 Jun 3

Zheng Q, Wang H, Xue C

There is substantial evidence that albumin-bound paclitaxel (nab-paclitaxel) is effective and safe for the treatment of breast, lung and pancreatic cancers. However, it can still cause adverse effects by affecting cardiac enzymes, hepatic enzyme metabolism and blood routine related indicators, which affects the use of chemotherapy for a full course of treatment. However, there are no relevant clinical studies to systematically observe the effects and dynamics of albumin-bound paclitaxel on cardiac enzymes, liver enzyme metabolism, and routine blood-related indices. The purpose of our study was to determine the levels of serum creatinine (Cre), aspartate aminotransferase (AST), alanine aminotransferase (ALT), lactate dehydrogenase (LDH), creatine kinase (CK), creatine kinase isoenzyme (CK-MB), white blood cells (WBC) and hemoglobin (HGB) in cancer patients treated with albumin-conjugated paclitaxel. This study retrospectively analyzed 113 patients with cancer. Patients who had received two cycles of nab-paclitaxel 260 mg/m2 (administered intravenously on days 1, 8, and 15 of each 28-day cycle) were selected. Serum Cre, AST, ALT, LDH, CK, and CK-MB activities, WBC counts, and HGB levels were measured before and after treatment with two cycles. Fourteen cancer types were analyzed. The distribution of cancer types in patients was mainly concentrated in lung, ovarian, and breast cancer. Nab-paclitaxel treatment markedly decreased Cre, AST, LDH, and CK activities in the serum and WBC counts and HGB levels, respectively. Serum Cre and CK activities and HGB levels were remarkably downregulated at baseline compared to healthy controls. Patients receiving nab-paclitaxel treatment cause metabolic disorders in tumor patients by reducing the decrease of Cre, AST, LDH, CK, CK-MB, WBC and HGB indexes, thus inducing the occurrence of cardiovascular events, hepatotoxic events and fatigue and other symptoms. Therefore, for tumor patients, although receiving nab-paclitaxel improves the anti-tumor effect, it is still necessary to closely monitor the changes of related enzymatic and routine blood indicators, so as to detect and intervene at an early stage.

324. Oligonucleotide mapping via mass spectrometry to enable comprehensive primary structure characterization of an mRNA vaccine against SARS-CoV-2.

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2023 Jun 3

Gau BC(#), Dawdy AW(#), Wang HL

325. Overexpression of fatty acid synthase attenuates bleomycin induced lung fibrosis by restoring mitochondrial dysfunction in mice.

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2023 Jun 3

Shin H(#), Park S(#), Hong J

326. Production of combustible fuels and carbon nanotubes from plastic wastes using an in-situ catalytic microwave pyrolysis process.

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2023 Jun 3

Irfan M, Saleem R, Shoukat B

327. The theory of thermoelasticity with a memory-dependent dynamic response for a thermo-piezoelectric functionally graded rotating rod.

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2023 Jun 3

Abouelregal AE, Askar SS, Marin M

328. Gold nanoparticle decorated post-synthesis modified UiO-66-NH(2) for A(3)-coupling preparation of propargyl amines.

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2023 Jun 3

Mohammadi L, Taghavi R, Hosseinifard M

329. Corrosion mitigation characteristics of some novel organoselenium thiourea derivatives for acid pickling of C1018 steel via experimental and theoretical study.

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2023 Jun 3

Abd El-Lateef HM, Khalaf MM, Gouda M

330. Comparative analysis of bats and rodents' genomes suggests a relation between non-LTR retrotransposons, cancer incidence, and ageing.

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2023 Jun 3

Ricci M, Peona V, Boattini A

331. Multicenter research priorities in pediatric CMR: results of a collaborative wiki survey.

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2023 Jun 3

Beroukhim RS, Merlocco A, Gerardin JF

332. A single-cell trajectory atlas of striatal development.

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2023 Jun 3

Anderson AG(#), Kulkarni A(#), Konopka G.

333. Effect of breed and diet on the M. longissimus thoracis et lumborum transcriptome of steers divergent for residual feed intake.

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2023 Jun 3

Keogh K(#), McKenna C(#), Waters SM

334. Exploring the cytotoxicity on human lung cancer cells and DNA binding stratagem of camptothecin functionalised silver nanoparticles through multi-spectroscopic, and calorimetric approach.

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2023 Jun 3

Raj A, Thomas RK, Vidya L

335. Quantum dynamics of a driven parametric oscillator in a Kerr medium.

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2023 Jun 3

Bolandhemmat E, Kheirandish F.

336. Introgression of SUB1 aggravates the susceptibility of the popular rice cultivars Swarna and Savitri to stagnant flooding.

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2023 Jun 3

Kuanar SR, Sarkar RK, Panigrahi R

337. Origin, genetic structure and evolutionary potential of the natural hybrid Ranunculus circinatus × R. fluitans.

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2023 Jun 3

Zalewska-Gałosz J, Kwiatkowska M, Prančl J

338. Entropy defect in thermodynamics.

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2023 Jun 3

Livadiotis G, McComas DJ.

339. The Japanese Guide affected the prescription of steroids for COVID-19 inpatients during the COVID-19 epidemic in Japan.

Sci Rep

2023 Jun 3

Higuchi T, Shin JH, Takada D

Since the outbreak of the coronavirus disease 2019 (COVID-19) pandemic, guidance ("Japanese Guide") has been published by a working group of several academic societies and announced by the Ministry of Health, Labour, and Welfare. Steroids as a candidate treatment for COVID-19 were noted in the Japanese Guide. However, the prescription details for steroids, and whether the Japanese Guide changed its clinical practice, were unclear. This study aimed to examine the impact of the Japanese Guide on the trends in the prescription of steroids for COVID-19 inpatients in Japan. We selected our study population using Diagnostic Procedure Combination (DPC) data from hospitals participating in the Quality Indicator/Improvement Project (QIP). The inclusion criteria were patients discharged from hospital between January 2020 and December 2020, who had been diagnosed with COVID-19, and were aged 18 years or older. The epidemiological characteristics of cases and the proportion of steroid prescriptions were described on a weekly basis. The same analysis was performed for subgroups classified by disease severity. The study population comprised 8603 cases (410 severe cases, 2231 moderate II cases, and 5962 moderate I/mild cases). The maximum proportion of cases prescribed with dexamethasone increased remarkably from 2.5 to 35.2% in the study population before and after week 29 (July 2020), when dexamethasone was included in the guidance. These increases were 7.7% to 58.7% in severe cases, 5.0% to 57.2% in moderate II cases, and 1.1% to 19.2% in moderate I/mild cases. Although the proportion of cases prescribed prednisolone and methylprednisolone decreased in moderate II and moderate I/mild cases, it remained high in severe cases. We showed the trends of steroid prescriptions in COVID-19 inpatients. The results showed that guidance can influence drug treatment provided during an emerging infectious disease pandemic.

340. Anemia as a risk factor for disease progression in patients admitted for COVID-19: data from a large, multicenter cohort study.

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2023 Jun 3

Veronese N, Segala FV, Carruba L

In respiratory infections, anemia is both a consequence of acute inflammation and a predictor of poor clinical outcomes. There are few studies investigating the role of anemia in COVID-19, suggesting a potential role in predicting disease severity. In this study, we aimed to assess the association between the presence of anemia at admission and incidence of severe disease and death in patients hospitalized for COVID-19. Data from all adult patients admitted for COVID-19 in University Hospital "P. Giaccone" Palermo, and University Hospital of Bari, Italy, were retrospectively collected from 1st of September 2020 to 31 August 2022. The association between anemia (defined as Hb < 13 g/dl and < 12 g/dl in males and females, respectively), in-hospital mortality and severe COVID-19 was tested using a Cox's regression analysis. Severe COVID-19 forms were defined as admission to intensive or sub-intensive care unit or a qSOFAscore ≥ 2 or CURB65scores ≥ 3. p values were calculated using the Student's t test for continuous variables and the Mantel-Haenszel Chi-square test for categorical ones. The association between anemia and the mortality was made using a Cox's regression analysis, adjusted, in two models, for the potential confounders and using a propensity score. Among the 1562 patients included in the analysis, prevalence of anemia was 45.1% (95% CI 43-48%). Patients with anemia were significantly older (p < 0.0001), reported more co-morbidities, and presented higher baseline levels of procalcitonin, CRP, ferritin and IL-6. Overall, the crude incidence of mortality was about four times higher in patients with anemia compared to those without. After adjusting for 17 potential confounders, the presence of anemia significantly increased the risk of death (HR = 2.68; 95% CI: 1.59-4.52) and of risk of severe COVID-19 (OR = 2.31; 95% CI: 1.65-3.24). The propensity score analysis substantially confirmed these analyses. Our study provides evidence that, in patients hospitalized for COVID-19, anemia is both associated with a more pronounced baseline pro-inflammatory profile and higher incidence of in-hospital mortality and severe disease.

341. Salmonella T3SS effector SseK1 arginine-glycosylates the two-component response regulator OmpR to alter bile salt resistance.

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2023 Jun 3

Hasan MK, Scott NE, Hays MP

342. Pneumonia detection with QCSA network on chest X-ray.

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2023 Jun 3

Singh S, Kumar M, Kumar A

343. A mechanistic interpretation of relativistic rigid body rotation.

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2023 Jun 3

Catheline S.

344. A refined information processing capacity metric allows an in-depth analysis of memory and nonlinearity trade-offs in neurocomputational systems.

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2023 Jun 29

Schulte To Brinke T, Dick M, Duarte R

345. Multi-objective optimization of multiple droplet impacts on a molten PCM using NSGA-II optimizer and artificial neural network.

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2023 Jun 29

Faghiri S, Poureslami P, Partovi Aria H

346. Downregulation of SODD mediates carnosol-induced reduction in cell proliferation in esophageal adenocarcinoma cells.

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2023 Jun 29

Li A, Cao W.

347. Machine learning assists in increasing the time resolution of X-ray computed tomography applied to mineral precipitation in porous media.

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2023 Jun 29

Lee D, Weinhardt F, Hommel J

348. Investigation of osmotic shock effect on pulsed electric field treated S. cerevisiae yeast cells.

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2023 Jun 29

Gančytė G, Šimonis P, Stirkė A.

349. Localized periodontitis severity associated with carotid intima-media thickness in young adults: CHIEF atherosclerosis study.

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2023 Jun 29

Tsai KZ, Huang WC, Chang YC

350. Reasons for high prevalence of contraceptive withdrawal in Tehran, Iran.

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2023 Jun 29

Erfani A, Kolahi AA.

This study explores reasons for withdrawal use that is highly prevalent in Iran. A face-to-face semi-structured survey questionnaire was designed and 79 married women aged 15-49, who were only using withdrawal when attending five primary healthcare centers in Tehran during September-October 2021 were interviewed. Results showed that withdrawal mostly was chosen by the couple (67%), and partly by the woman alone (19%) or by the husband alone (14%). Participants evaluated withdrawal positively that has no side effect and cost, is easy to use and accessible, and increases sexual pleasure and intimacy. Most women agreed that husbands use withdrawal to protect their wife's health (76%). Women obtained contraceptive information primarily from gynecologists (42%), the internet (21%), midwives in public health centers (19%), and social networks (18%). "Side effects of modern methods" (37%), "fear of side effects" (16%), and "reduction in sexual pleasure" (14%) were the major reasons reported for using withdrawal. While 'side effects' was given mostly by women who alone or with their husband chose withdrawal (52%, 38%), 'reduction in sexual pleasure' and 'fear of side effects' were mostly reported by women whose husband was the sole decision maker in choosing withdrawal (28%, 25%). The 'fear of side effects' was reported mostly by women who had lower education (21%), used the internet for contraceptive information (23%), and whose husband alone chose withdrawal (25%). Cost of modern methods was a trivial reason for using withdrawal. Most withdrawal users (75%) would not switch to modern methods even if they were freely accessible. More educated women and their husbands would be less likely to switch to modern methods even they were provided freely (OR 0.28, CI 0.10-0.80; OR 0.20, CI 0.07-0.59). However, women who were using modern methods before, and those who alone chose withdrawal would be more likely to switch to modern methods (OR 6.4, CI 2.0-20.2; OR 3.4, CI 1.1-11.2). Access to regular contraceptive counselling and public health campaigns could help women to deal with fears of side effects of modern methods, learn their proper use, and to receive education on how to use withdrawal more effectively to avoid unintended pregnancies.

351. A procedure and model for the identification of uni- and biarticular structures passive contribution to inter-segmental dynamics.

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2023 Jun 29

Koussou A, Dumas R, Desailly E.

352. Improved sustainability of solar panels by improving stability of amorphous silicon solar cells.

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2023 Jun 29

Ganguly G.

353. Cancer associated macrophage-like cells in metastatic renal cell carcinoma predicts for poor prognosis and tracks treatment response in real time.

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2023 Jun 29

Ali A, Adams DL, Kasabwala DM

354. Touch events and human activities for continuous authentication via smartphone.

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2023 Jun 29

Gattulli V(#), Impedovo D(#), Pirlo G(#)

355. The full-body illusion changes visual depth perception.

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2023 Jun 29

Bayer M, Betka S, Herbelin B

356. Performance optimization of efficient PbS quantum dots solar cells through numerical simulation.

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2023 Jun 29

Kumar S, Bharti P, Pradhan B.

357. Different incidences of diabetic retinopathy requiring treatment since diagnosis according to the course of diabetes diagnosis: a retrospective cohort study.

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2023 Jun 29

Sugiyama T, Yanagisawa-Sugita A, Tanaka H

358. Stabilizer codes for open quantum systems.

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2023 Jun 29

Pereira FRF, Mancini S, La Guardia GG.

359. Skin cancer risk of menopausal hormone therapy in a Korean cohort.

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2023 Jun 29

Yuk JS, Lee SK, Uh JA

360. Physiology of Saccharomyces cerevisiae during growth on industrial sugar cane molasses can be reproduced in a tailor-made defined synthetic medium.

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2023 Jun 29

Eliodório KP(#), Cunha GCGE(#), Lino FSO

361. Laboratory investigation of GO-SA-MWCNTs ternary hybrid nanoparticles efficacy on dynamic viscosity and wear properties of oil (5W30) and modeling based on machine learning.

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2023 Jun 29

Sepehrnia M, Davoodabadi Farahani S, Hamidi Arani A

362. Time-dependent cytokines changes in ultra-rush wasp venom immunotherapy.

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2023 Jun 29

Urbańska W, Szymański L, Ciepelak M

363. Novel gain-tuning for sliding mode control of second-order mechanical systems: theory and experiments.

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2023 Jun 29

Xuan-Mung N, Nguyen NP, Pham DB

364. Evaluation of the cardiac subvolume dose and myocardial perfusion in left breast cancer patients with postoperative radiotherapy: a prospective study.

Sci Rep

2023 Jun 29

Wang SY(#), Lin KH(#), Wu YW

Adjuvant breast radiotherapy could reduce the risk of local recurrence. However, the radiation dose received by the heart also increases the risk of cardiotoxicity and causes consequential heart diseases. This prospective study aimed to evaluate more precisely cardiac subvolume doses and corresponding myocardial perfusion defects according to the American Heart Association (AHA)'s 20-segment model for single photon emission computed tomography (SPECT) myocardial perfusion imaging (MPI) interpretation for breast cancer after radiotherapy. The 61 female patients who underwent adjuvant radiotherapy following breast cancer surgery for left breast cancer were enrolled. SPECT MPI were performed before radiotherapy for baseline study, and 12 months after for follow-up. Enrolled patients were divided into two groups, new perfusion defect (NPD) and non new perfusion defect found (non-NPD) according to myocardial perfusion scale score. CT simulation data, radiation treatment planning, and SPECT MPI images were fused and registered. The left ventricle was divided into four rings, three territories, and 20 segments according to the AHA's 20-segment model of the LV. The doses between NPD and non-NPD groups were compared by the Mann-Whitney test. The patients were divided into two groups: NPD group (n = 28) and non-NPD group (n = 33). The mean heart dose was 3.14 Gy in the NPD group and 3.08 Gy in the non-NPD group. Mean LV doses were 4.84 Gy and 4.71 Gy, respectively. The radiation dose of the NPD group was higher than the non-NPD group in the 20 segments of LV. There was significant difference in segment 3 (p = 0.03). The study indicated that the radiation doses to 20 segments of LV in NPD were higher than those in non-NPD significantly at segment 3, and higher in other segments in general. In the bull's eye plot combining radiation dose and NPD area, we found that the new cardiac perfusion decline may exist even in the low radiation dose region.Trial registration: FEMH-IRB-101085-F. Registered 01/01/2013, https://clinicaltrials.gov/ct2/show/NCT01758419?cond=NCT01758419&draw=2&rank=1 .

365. Combination of expert guidelines-based and machine learning-based approaches leads to superior accuracy of automated prediction of clinical effect of copy number variations.

Sci Rep

2023 Jun 29

Sládeček T, Gažiová M, Kucharík M

366. Establishment of a protocol to administer immunosuppressive drugs for iPS cell-derived cardiomyocyte patch transplantation in a rat myocardial infarction model.

Sci Rep

2023 Jun 29

Ito E, Kawamura A, Kawamura T

367. Modified ulnar lengthening for correction of the Masada type 2 forearm deformity in hereditary multiple exostosis.

Sci Rep

2023 Jun 29

Cao S, Zeng JF, Xiao S

368. Assessing the impact of protonating acid combinations in e-cigarette liquids: a randomised, crossover study on nicotine pharmacokinetics.

Sci Rep

2023 Jun 29

Frosina J, McEwan M, Ebajemito J

369. Investigating the possibility of extending the BWR cycle length for 15 years of operation by mixing highly enriched UO(2) fuel with burnable absorbers.

Sci Rep

2023 Jun 29

Mustafa SS.

370. Portable impedance-sensing device for microorganism characterization in the field.

Sci Rep

2023 Jun 29

Bouzid K, Greener J, Carrara S

371. A Monte Carlo algorithm to improve the measurement efficiency of low-field nuclear magnetic resonance.

Sci Rep

2023 Jun 29

Guo P, Zhang R, Zhang J

372. Feasibility of using intermittent active monitoring of vital signs by smartphone users to predict SARS-CoV-2 PCR positivity.

Sci Rep

2023 Jun 29

Dolezalova N, Gkrania-Klotsas E, Morelli D

373. Non-contrast CT synthesis using patch-based cycle-consistent generative adversarial network (Cycle-GAN) for radiomics and deep learning in the era of COVID-19.

Sci Rep

2023 Jun 29

Kalantar R(#), Hindocha S(#), Hunter B

374. The NK cell checkpoint NKG2A maintains expansion capacity of human NK cells.

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2023 Jun 29

Kaulfuss M, Mietz J, Fabri A

375. Immunomodulatory response in an experimental model of brain death.

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2023 Jun 29

Santana AC, Andraus W, Zimelewicz Oberman D

376. Divalent cations in human liver pyruvate kinase exemplify the combined effects of complex-equilibrium and allosteric regulation.

Sci Rep

2023 Jun 29

Martin TA, Fenton AW.

377. SpineTool is an open-source software for analysis of morphology of dendritic spines.

Sci Rep

2023 Jun 29

Ekaterina P(#), Peter V(#), Smirnova D

378. Quantum Otto heat engine with Pöschl-Teller potential in contact with coherent thermal bath.

Sci Rep

2023 Jun 29

Abasabadi SH, Mirafzali SY, Baghshahi HR.

379. Association of different obesity patterns with hypertension in US male adults: a cross-sectional study.

Sci Rep

2023 Jun 29

Chen L(#), Zhang J(#), Zhou N

Obesity is an important risk factor for hypertension. We aimed to investigate the association between different obesity patterns and hypertension risk in a large male population in the US. Male participants from the National Health and Nutrition Examination Survey (NHANES) (2007-2018) were enrolled in this cross-sectional study. Social demographic information, lifestyle factors, anthropometric measurements and biochemical measurements were collected. Three obesity patterns were classified according to the body mass index (BMI) and waist circumference (WC), including overweight and general obesity, abdominal obesity, and compound obesity. We adopted multivariate logistic regression to investigate the associations between hypertension and different obesity patterns after adjusting for cofounding factors. Subgroup analysis, stratified by age, smoking, drinking and estimated glomerular filtration rate (eGFR), was also conducted to explore the associations between obesity patterns and hypertension risk among different populations. Moreover, the association between WC and hypertension among male individuals was also explored using restricted cubic spline (RCS) analysis. Receiver operating characteristic (ROC) was used to evaluate the discriminatory power of WC for screening hypertension risk. 13,859 male participants from NHANES survey (2007-2018) were enrolled. Comparing with the normal-weight group, the odds ratios (ORs) [95% confidence interval (CI)] for hypertension in individuals with overweight and general obesity, abdominal obesity and compound obesity were 1.41 [1.17-1.70], 1.97 [1.53-2.54] and 3.28 [2.70-3.99], respectively. Subgroup analysis showed that the effect of different obesity patterns on hypertension risk was highly stable among individuals with different clinical conditions. In addition, WC had a positive correlation with the risk of hypertension (OR: 1.43; 95% CI 1.37-1.52; P < 0.001) in fully adjusted multivariate logistic regression model. RCS analysis showed that the association between WC and hypertension risk was in a nonlinear pattern, and WC had a good discriminatory power for hypertension in ROC analysis. Different patterns of obesity have a great impact on the risk of hypertension among male individuals. Increment of WC significantly increased the hypertension risk. More attention should be paid to the prevention of obesity, especially abdominal obesity and compound obesity in male individuals.

380. Influenza transmissibility among patients and health-care professionals in a geriatric short-stay unit using individual contact data.

Sci Rep

2023 Jun 29

Gustin MP, Pujo-Menjouet L, Vanhems P.

381. Applying cosmetic oil with added aromatic compounds improves tactile sensitivity and skin properties.

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2023 Jun 29

Samain-Aupic L, Gilbert L, André N

382. Versatile properties of dynein molecules underlying regulation in flagellar oscillation.

Sci Rep

2023 Jun 29

Fujiwara T, Shingyoji C, Higuchi H.

383. Identification of hypoxia-related genes and exploration of their relationship with immune cells in ischemic stroke.

Sci Rep

2023 Jun 29

Yang K, Zhang Z, Liu X

Ischemic stroke (IS) is a major threat to human health, and it is the second leading cause of long-term disability and death in the world. Impaired cerebral perfusion leads to acute hypoxia and glucose deficiency, which in turn induces a stroke cascade response that ultimately leads to cell death. Screening and identifying hypoxia-related genes (HRGs) and therapeutic targets is important for neuroprotection before and during brain recanalization to protect against injury and extend the time window to further improve functional outcomes before pharmacological and mechanical thrombolysis. First, we downloaded the GSE16561 and GSE58294 datasets from the NCBI GEO database. Bioinformatics analysis of the GSE16561 dataset using the limma package identified differentially expressed genes (DEGs) in ischemic stroke using adj. p. values < 0.05 and a fold change of 0.5 as thresholds. The Molecular Signature database and Genecards database were pooled to obtain hypoxia-related genes. 19 HRGs associated with ischemic stroke were obtained after taking the intersection. LASSO regression and multivariate logistic regression were applied to identify critical biomarkers with independent diagnostic values. ROC curves were constructed to validate their diagnostic efficacy. We used CIBERSORT to analyze the differences in the immune microenvironment between IS patients and controls. Finally, we investigated the correlation between HRGs and infiltrating immune cells to understand molecular immune mechanisms better. Our study analyzed the role of HRGs in ischemic stroke. Nineteen hypoxia-related genes were obtained. Enrichment analysis showed that 19 HRGs were involved in response to hypoxia, HIF-1 signaling pathway, autophagy, autophagy of mitochondrion, and AMPK signaling pathway. Because of the good diagnostic properties of SLC2A3, we further investigated the function of SLC2A3 and found that it is closely related to immunity. We have also explored the relevance of other critical genes to immune cells. Our findings suggest that hypoxia-related genes play a crucial role in the diversity and complexity of the IS immune microenvironment. Exploring the association between hypoxia-related critical genes and immune cells provides innovative insights into the therapeutic targets for ischemic stroke.

384. Measurements and predictions of diffusible hydrogen escape and absorption in catholically charged 316LN austenitic stainless steel.

Sci Rep

2023 Jun 29

Weihrauch M, Patel M, Patterson EA.

385. Screening autism-associated environmental factors in differentiating human neural progenitors with fractional factorial design-based transcriptomics.

Sci Rep

2023 Jun 29

Arora A, Becker M, Marques C

386. Biliatresone induces cholangiopathy in C57BL/6J neonates.

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2023 Jun 29

Schmidt HC, Hagens J, Schuppert P

387. Mechanism of TNFα-induced downregulation of salt-inducible kinase 2 in adipocytes.

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2023 Jun 29

Vaváková M, Hofwimmer K, Laurencikiene J

388. Exogenous AMPA downregulates gamma-frequency network oscillation in CA3 of rat hippocampal slices.

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2023 Jun 29

Li C(#), Li Z(#), Xu S(#)

389. Sickness absence transitions among Swedish twins with back, neck or shoulder pain and common mental disorders applying a multi-state approach.

Sci Rep

2023 Jun 29

Kärkkäinen S, Bergström J, Ropponen A

390. Small mammals reduce activity during high moon illumination under risk of predation by introduced predators.

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2023 Jun 29

Taylor P, Swan M, Sitters H

391. Image quality assessment using deep learning in high b-value diffusion-weighted breast MRI.

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2023 Jun 29

Kapsner LA, Balbach EL, Folle L

392. Impact of sea level rise on the Mediterranean Lithophyllum byssoides rims.

Sci Rep

2023 Jun 29

Blanfuné A, Boudouresque CF, Verlaque M

393. Hydro-morphological behavior around T-shaped spur dikes with downward seepage.

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2023 Jun 28

Patel HK, Kumar B.

394. Developing home cleaning intervention through community engagement to reduce infections and antimicrobial resistance in Ghanaian homes.

Sci Rep

2023 Jun 28

Tsekleves E, de Souza D, Pickup R

Globally Antimicrobial Resistance (AMR) constitutes a health crisis, particularly in developing countries, where infectious disease are commonly fatal. There is clear evidence for microbial exposure and infection transmission within the home. Personal and environmental hygiene are the best ways of reducing household infections thus decreasing the need for antibiotics and consequently diminishing AMR. Despite this being an obvious step, research efforts to understand the home environment and its impact on AMR, cleaning and possible interventions on household cleaning are limited. We combined design and microbiology methods in an innovative mixed-method approach. A traditional survey design (n = 240), a design ethnography (n = 12), a co-design workshop and a pre-intervention microbiological dust sample analysis was undertaken to provide insights for codesign workshops in which new cleaning practices might be developed to minimise any AMR bacteria present in the household environments located in the Greater Accra Region of Ghana. Microbiological analysis of household dust showed that 36.6% of bacterial isolates detected were found to carry at least one resistance to the panel of antibiotics tested. Four scenarios were generated from an economic segmentation of the survey data. 50 ethnographic insights were 'presented' and descriptions of 12 bacteria species that showed resistance to one or more antibiotics (representing 176 bacterial isolates that showed resistance to one or more antibiotics found in the dust samples) were presented to the participants in a codesign workshop. An intervention, a new regime of cleaning practices agreed through the co-design workshop and practiced for thirty days, was made in (n = 7) households. The high prevalence of multidrug resistance observed in this study indicate the need for antibiotics surveillance program, not only in hospital settings but also in the household environment. There is, thus, an urgent need for targeting of interventions at the household level. Activating knowledge through community engagement in the research helps in increasing public perception and breaking down the scientist-public barrier.

395. Induction of glioblastoma cell ferroptosis using combined treatment with chloramphenicol and 2-deoxy-D-glucose.

Sci Rep

2023 Jun 28

Miki K, Yagi M, Noguchi N

396. An Alzheimer's disease category progression sub-grouping analysis using manifold learning on ADNI.

Sci Rep

2023 Jun 28

van der Haar D, Moustafa A, Warren SL

397. Conflicting findings on the effectiveness of hydrogen therapy for ameliorating vascular leakage in a 5-day post hypoxic-ischemic survival piglet model.

Sci Rep

2023 Jun 28

Htun Y, Nakamura S, Nakao Y

398. The effect of dietary approaches to stop hypertension and ketogenic diets intervention on serum uric acid concentration: a systematic review and meta-analysis of randomized controlled trials.

Sci Rep

2023 Jun 28

Gohari S, Ghobadi S, Jafari A

399. Genomic analysis of Anderson typing phages of Salmonella Typhimrium: towards understanding the basis of bacteria-phage interaction.

Sci Rep

2023 Jun 28

Mohammed M, Casjens SR, Millard AD

400. Tuning of the Brillouin scattering properties in microstructured optical fibers by liquid infiltration.

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2023 Jun 28

Catalano E, Vallifuoco R, Zeni L

401. Leveraging deep survival models to predict quality of care risk in diverse hospital readmissions.

Sci Rep

2023 Jun 28

Tran NQ, Goel G, Pudota N

402. Generation of potentially inhibitory autoantibodies to ADAMTS13 in coronavirus disease 2019.

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2023 Jun 28

Doevelaar AAN, Bachmann M, Hölzer B

403. Identification of ecdysone receptor target genes in the worker honey bee brains during foraging behavior.

Sci Rep

2023 Jun 28

Iino S, Oya S, Kakutani T

404. Quality by design paradigm for optimization of green stability indicating HPLC method for concomitant determination of fluorescein and benoxinate.

Sci Rep

2023 Jun 28

Kamal AH, Habib AA, Hammad SF

405. Not brushing teeth at night may increase the risk of cardiovascular disease.

Sci Rep

2023 Jun 28

Isomura ET, Suna S, Kurakami H

406. N-glycans from serum IgG and total serum glycoproteins specific for endometriosis.

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2023 Jun 28

Kovács Z, Reidy F, Glover L

407. Influence of Ca doping in structural, electronic, optical and mechanical properties of Ba(1-x)Ca(x)TiO(3) perovskite from first-principles investigation.

Sci Rep

2023 Jun 28

Hasan Z, Rahman MA, Das DK

Nowadays, perovskite materials are well known for electronics and optoelectronics applications. We have investigated a potential candidate for those applications to compare the applicability in optoelectronics, photorefractive and photovoltaic (PV) devices. The systematic comparative study of the structural, electronic, optical, mechanical, and thermodynamic properties of pure BaTiO3 and Ca doped BaTiO3 (Ba1-xCaxTiO3 where x = 0.125, 0.25, 0.375, 0.500, 0.625) perovskite have been carried out using first-principles and density-functional-theory calculations as recently this material was mostly experimented. The measured structural parameters from the geometrically optimized structure of cubic BT ceramic compared with the other theoretical values. A crystal phase transition occurs when doping content x = 0.25. The electronic band structure shows that the nature of the bandgap is changed from indirect bandgap to direct bandgap energy at G-point after doping the Ca atom into BaTiO3 (BT) crystal. Doping of Ca into BT has led to bandstructure modification including conduction band (CB) shifting toward the higher energy level. Electronic properties have been reported to examine the contribution of different orbitals to the CB and to the valance band (VB). This study investigated the modification of optical properties such as absorption, reflectivity, refractive index, extinction coefficient, conductivity, dielectric function and loss function at the energy range from 0 to 30 eV. The prominent absorption peak and optical energy were observed at the UV light energy region. Based on the optical behavior of the material this theoretical research suggests that the doped BT solution is a suitable candidate for photorefractive and optoelectronic devices. Different elastic constants reveal mechanical stability and the existence of the covalent bond of those compounds. Debye temperature increases with doping content. Hence modification of BaTiO3 crystal by Ca atom significantly develop various properties that led it to multifunctional applications.

408. Gene-specific machine learning for pathogenicity prediction of rare BRCA1 and BRCA2 missense variants.

Sci Rep

2023 Jun 28

Kang M, Kim S, Lee DB

409. A moment kernel machine for clinical data mining to inform medical decision making.

Sci Rep

2023 Jun 28

Yu YC, Zhang W, O'Gara D

410. A novel approach for the analysis of single-cell RNA sequencing identifies TMEM14B as a novel poor prognostic marker in hepatocellular carcinoma.

Sci Rep

2023 Jun 28

Ma D(#), Liu S(#), He Q(#)

411. Interaction of various-sized particles in river flow.

Sci Rep

2023 Jun 28

Fan N, Zhong Q, Nie R

412. Maternal racism experience and cultural identity in relation to offspring telomere length.

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2023 Jun 28

Thayer Z, Becares L, Marks E

413. Influence of droplet size on the antibacterial efficacy of citral and citronella oil nanoemulsions in polysaccharide coated fresh-cut apples.

Sci Rep

2023 Jun 28

Touayar M, Zayani R, Messaoud C

414. iMPI: portable human-sized magnetic particle imaging scanner for real-time endovascular interventions.

Sci Rep

2023 Jun 28

Vogel P, Rückert MA, Greiner C

415. Decomposing acute malnutrition by educational inequality of mother's among under five children in Jammu and Kashmir.

Sci Rep

2023 Jun 28

Tariq I(#), Khan JI(#), Malik MA(#).

Health outcomes in the state of Jammu and Kashmir have shown improvement in recent decades. However, nutritional achievements, particularly among children under the age of five, have not seen similar progress. Various factors influence the nutritional status of this age group, with the socio-cultural and biological attributes of mothers being considered significant determinants. While some studies have examined these attributes, there is a scarcity of research exploring the causal link between socio-culturally determined factors, such as maternal education, and child nutritional achievements, especially in Indian states located in North India. This paper aims to address this gap by analysing the prevalence of acute malnutrition (stunting) among children under five in Jammu and Kashmir in relation to educational inequality among mothers. The latest round of the National Family Health Survey (NFHS-5) is used to assess the levels of stunting (low height for age) among children, considering the literacy status of mothers and other control variables. Bivariate and multivariable methods are employed to study the association and identify risk factors. Additionally, the Oaxaca decomposition method is used to analyse the educational gap in factors associated with child stunting. The results indicate a higher prevalence of stunting among children of uneducated mothers (29%) compared to those of educated mothers (25%). The findings demonstrate a lower risk of stunting among children whose mothers are literate (OR 0.89). The Oaxaca decomposition analysis reveals a statistically significant difference in stunting between children based on their mother's education. These results highlight the wide disparities in acute malnutrition among children due to variations in maternal education. It is therefore crucial for policymakers to prioritize efforts to reduce educational disparities in order to alleviate the nutritional burden faced by children.

416. Long-term fungal inoculation of Ficus sycomorus and Tectona grandis woods with Aspergillus flavus and Penicillium chrysogenum.

Sci Rep

2023 Jun 28

Mansour MMA, Mohamed WA, El-Settawy AAA

417. Partially substituting chemical NPK fertilizers and their impact on Eureka lemon trees (Citrus limon L. Burm) productivity and fruit quality.

Sci Rep

2023 Jun 28

Almadiy AA, Shaban AE, Ibrahim AM

418. A novel approach based on neutrosophic Bonferroni mean operator of trapezoidal and triangular neutrosophic interval environments in multi-attribute group decision making.

Sci Rep

2023 Jun 28

Nagarajan D, Kanchana A, Jacob K

419. Targeted treatment of severe vascular malformations harboring PIK3CA and TEK mutations with alpelisib is highly effective with limited toxicity.

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2023 Jun 28

Sterba M(#), Pokorna P, Faberova R

420. Deep learning and ultrasound feature fusion model predicts the malignancy of complex cystic and solid breast nodules with color Doppler images.

Sci Rep

2023 Jun 28

Liu H(#), Hou CJ(#), Tang JL

421. Representational momentum of biological motion in full-body, point-light and single-dot displays.

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2023 Jun 28

Zucchini E(#), Borzelli D(#), Casile A.

422. Strengths of social ties modulate brain computations for third-party punishment.

Sci Rep

2023 Jun 28

Tang Z(#), Qu C(#), Hu Y

423. Endoscopic resection for local residual or recurrent cancer after definitive chemoradiotherapy or radiotherapy for esophageal squamous cell carcinoma.

Sci Rep

2023 Jun 28

Tani Y, Ishihara R, Matsuura N

424. Electrochemical, surface analysis, computational and anticorrosive studies of novel di-imine Schiff base on X65 steel surface.

Sci Rep

2023 Jun 28

Nasser A, Migahed MA, El Basiony NM

The inhibitory effect of di-imine-SB namely ((N1Z, N4E)-N1, N4-bis (4 (dimethylamino) benzylidene) butane 1,4-diamine) on X65-steel in 1 M HCl has been investigated experimentally and theoretically. The electrochemical impedance spectroscopy (EIS), potentiodynamic polarization (PDP), and weight loss outcomes display the anticorrosion properties of "di-imine- SB". The inhibitory efficiency exceeds 90% at the optimal concentration of 1 × 10-3 M "di-imine- SB". The metal surface was examined further using scanning electron microscope (SEM) and energy dispersive X-ray (EDX). The effectiveness of the di-imine-SB is returned into its adsorption on X65-steel surface and found in agreement with Langmuir adsorption isotherm. According to the standard Gibbs free energy of adsorption [Formula: see text], di-imine-SB adsorption tends to be chemical rather than physical, it increases the activation energy ([Formula: see text]) of metal dissolution reaction and makes it hard to occur. The PDP data suggested anodic and cathodic type of the di-imine-SB inhibitor. Meanwhile, increasing the resistance of X65-steel to 301 Ω cm2 after adding 1 mM of di-imine-SB confirms its protective effect. Whereas, the positive value of the fraction of electron transference (ΔN, 0.746), confirms the affinity of di-imine-SB to share electrons to the partially filed 3d-orbital of Fe forming strong protective film over X65-steel surface. Aided by Monte Carlo (MC) simulation, the calculated adsorption energy (Eads) suggests excessive adsorption affinity of di-imine-SB on metal surface over the corrosive chlorides and hydronium ions. A good correlation between the theoretical hypothesis and the experimental inhibition efficiency has been achieved. The comparative study showed the superior of the di-imine-SB as potential corrosion inhibitor compared with those reported before. Finally, global reactivity descriptors; electron affinity (A), ionization potential (I), electronegativity (χ), dipole moment (µ), global hardness ([Formula: see text]), electrophilicity index and, Fukui indices were also calculated and found well correlated to the reactivity of di-imine-SB.

425. The effect of COVID-19 on nuclear medicine and radiopharmacy activities: A global survey.

Sci Rep

2023 Jun 28

Al-Saeedi F, Rajendran P, Tipre D

426. Complementary use of statistical parametric mapping and gait profile score to describe walking alterations in multiple sclerosis: a cross-sectional study.

Sci Rep

2023 Jun 28

Mestanza Mattos FG, Luciano F, Lencioni T

427. Analysis of interaction dynamics and rogue wave localization in modulation instability using data-driven dominant balance.

Sci Rep

2023 Jun 28

Ermolaev AV, Mabed M, Finot C

428. The significance of decompressive craniectomy for older patients with traumatic brain injury: a propensity score matching analysis from large multi-center data.

Sci Rep

2023 Jun 28

Kim JH, Park KJ, Kang SH

429. Elevated third trimester corticosteroid levels are associated with fewer offspring infections.

Sci Rep

2023 Jun 28

Prince N, Kelly RS, Chu SH

Respiratory infections are a leading cause of morbidity and mortality in early life, and recurrent infections increase the risk of developing chronic diseases. The maternal environment during pregnancy can impact offspring health, but the factors leading to increased infection proneness have not been well characterized during this period. Steroids have been implicated in respiratory health outcomes and may similarly influence infection susceptibility. Our objective was to describe relationships between maternal steroid levels and offspring infection proneness. Using adjusted Poisson regression models, we evaluated associations between sixteen androgenic and corticosteroid metabolites during pregnancy and offspring respiratory infection incidence across two pre-birth cohorts (N = 774 in VDAART and N = 729 in COPSAC). Steroid metabolites were measured in plasma samples from pregnant mothers across all trimesters of pregnancy by ultrahigh-performance-liquid-chromatography/mass-spectrometry. We conducted further inquiry into associations of steroids with related respiratory outcomes: asthma and lung function spirometry. Higher plasma corticosteroid levels in the third trimester of pregnancy were associated with lower incidence of offspring respiratory infections (P = 4.45 × 10-7 to 0.002) and improved lung function metrics (P = 0.020-0.036). Elevated maternal androgens were generally associated with increased offspring respiratory infections and worse lung function, with some associations demonstrating nominal significance at P < 0.05, but these trends were inconsistent across individual androgens. Increased maternal plasma corticosteroid levels in the late second and third trimesters were associated with lower infections and better lung function in offspring, which may represent a potential avenue for intervention through corticosteroid supplementation in late pregnancy to reduce offspring respiratory infection susceptibility in early life.Clinical Trial Registry information: VDAART and COPSAC were originally conducted as clinical trials; VDAART: ClinicalTrials.gov identifier NCT00920621; COPSAC: ClinicalTrials.gov identifier NCT00798226.

430. United States politicians' tone became more negative with 2016 primary campaigns.

Sci Rep

2023 Jun 28

Külz J, Spitz A, Abu-Akel A

431. The mechanism and performance of rock breakage by undercutting disc cutter with advanced slotting.

Sci Rep

2023 Jun 28

Jiang H, Zhang X, Zhao H

To study the mechanism and performance of rock breakage by an undercutting disc cutter with advanced slotting, a three-dimensional numerical model of rock cutting by a disc cutter with advanced slotting assistance was established based on the discrete element method. The parallel bond constitutive model was selected to describe the micromechanical properties of rock. The correctness of the established numerical model is verified through rock breakage experiments, and the rock cutting process by the disc cutter was analyzed by a combination of the force chain and crack distribution. The influencing factors, such as advanced slotting depth, cutting thickness, rock strength, and cutter rotation speed, on rock cutting performance were investigated. The results show that a compact zone is gradually formed between the rock and disc cutter at the beginning, then a large number of microscopic tensile and shear cracks in the compact zone due to micro failure of rock are formed; the subsequent main rock fragment is mainly caused by tensile failure; advanced slotting can reduce the rock bearing capacity and bending resistance, the rock above the advanced slotting fractured easily due to its lower bending resistance, and the volume compact zone is relatively small. When the advanced slotting depth is equal to 12.5 mm, the propulsive force and specific energy consumption of rock cutting by the disc cutter are reduced by 61.6% and 16.5%, respectively. The propulsive force and specific energy consumption increase as the rock strength increases, but they tend to close when the rock strength is greater than 80 MPa, which indicates that advanced slotting assistance is more suitable for hard rock. The results obtained in this paper can provide the operating parameters determination under different factors to some extent of the undercutting disc cutter in a pre-cut condition, which further improve the rock breaking performance of mechanized cutter.

432. Amifostine attenuates bleomycin-induced pulmonary fibrosis in mice through inhibition of the PI3K/Akt/mTOR signaling pathway.

Sci Rep

2023 Jun 28

Yang W(#), Pan L(#), Cheng Y

433. Declining incidence of cerebral palsy in South Korea.

Sci Rep

2023 Jun 28

Kim GH, Lee G, Ha S

434. Detection of incomplete atypical femoral fracture on anteroposterior radiographs via explainable artificial intelligence.

Sci Rep

2023 Jun 27

Kim T(#), Moon NH(#), Goh TS

435. Identification of candidate lethal haplotypes and genomic association with post-natal mortality and reproductive traits in Nellore cattle.

Sci Rep

2023 Jun 27

Schmidt PI, Mota LFM, Fonseca LFS

The wide use of genomic information has enabled the identification of lethal recessive alleles that are the major genetic causes of reduced conception rates, longer calving intervals, or lower survival for live-born animals. This study was carried out to screen the Nellore cattle genome for lethal recessive haplotypes based on deviation from the expected population homozygosity, and to test SNP markers surrounding the lethal haplotypes region for association with heifer rebreeding (HR), post-natal mortality (PNM) and stayability (STAY). This approach requires genotypes only from apparently normal individuals and not from affected embryos. A total of 62,022 animals were genotyped and imputed to a high-density panel (777,962 SNP markers). Expected numbers of homozygous individuals were calculated, and the probabilities of observing 0 homozygotes was obtained. Deregressed genomic breeding values [(G)EBVs] were used in a GWAS to identify candidate genes and biological mechanisms affecting HR, STAY and PNM. In the functional analyses, genes within 100 kb down and upstream of each significant SNP marker, were researched. Thirty haplotypes had high expected frequency, while no homozygotes were observed. Most of the alleles present in these haplotypes had a negative mean effect for PNM, HR and STAY. The GWAS revealed significant SNP markers involved in different physiological mechanisms, leading to harmful effect on the three traits. The functional analysis revealed 26 genes enriched for 19 GO terms. Most of the GO terms found for biological processes, molecular functions and pathways were related to tissue development and the immune system. More phenotypes underlying these putative regions in this population could be the subject of future investigation. Tests to find putative lethal haplotype carriers could help breeders to eliminate them from the population or manage matings in order to avoid homozygous.

436. Ion mobility mass spectrometry for the study of mycobacterial mycolic acids.

Sci Rep

2023 Jun 27

Liu Y, Kaffah N, Pandor S

437. Mediating role of resilience in the relationships of physical activity and mindful self-awareness with peace of mind among college students.

Sci Rep

2023 Jun 27

Liao YC, Huang TY, Lin SH

438. Plastiglomerates from uncontrolled burning of plastic waste on Indonesian beaches contain high contents of organic pollutants.

Sci Rep

2023 Jun 27

Utami DA, Reuning L, Schwark L

439. A novel retinoic acid drug, EYE-502, inhibits choroidal neovascularization by targeting endothelial cells and pericytes.

Sci Rep

2023 Jun 27

Shen Y(#), Xu M(#), Ren L(#)

440. Antioxidant system of garden cress sprouts for using in bio-monitor of cadmium and lead contamination.

Sci Rep

2023 Jun 27

Abdel-Aty AM, Elsayed AM, Gad AAM

441. The distinction between irritability and anger and their associations with impulsivity and subjective wellbeing.

Sci Rep

2023 Jun 27

Gröndal M, Ask K, Winblad S.

442. BMP-induced non-canonical signaling is upregulated during autophagy-mediated regeneration in inflamed mesothelial cells.

Sci Rep

2023 Jun 27

Zsiros V, Dóczi N, Petővári G

443. The tardigrade protein CAHS D interacts with, but does not retain, water in hydrated and desiccated systems.

Sci Rep

2023 Jun 27

Sanchez-Martinez S, Ramirez JF, Meese EK

444. Anti-TNF-α therapy induced psoriasis in rheumatoid arthritis patients according to FDA postmarketing surveillance data.

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2023 Jun 27

Joulfayan H, Makunts T, Abagyan R.

445. Effects of porous structure on the deformation failure mechanism of cement sheaths for wellbores.

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2023 Jun 27

Yang Y, Li X, Sun M

446. Comparative genomics of infective Saccharomyces cerevisiae strains reveals their food origin.

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2023 Jun 27

Morard M(#), Pérez-Través L(#), Perpiñá C

447. Chain-specificity of laminin α1-5 LG45 modules in the recognition of carbohydrate-linked receptors and intramolecular binding.

Sci Rep

2023 Jun 27

Matsunuma M, Kan R, Yamada Y

448. Integrating GWAS and proteome data to identify novel drug targets for MU.

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2023 Jun 27

Wu Y(#), Song J(#), Liu M

449. Morphologic analysis of the foveal avascular zone for prediction of postoperative visual acuity in advanced idiopathic epiretinal membrane.

Sci Rep

2023 Jun 27

Kim GH, Hwang BE, Chun H

450. Deep neural network analysis models for complex random telegraph signals.

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2023 Jun 27

Robitaille M(#), Yang H(#), Wang L

451. Rock fragmentation indexes reflecting rock mass quality based on real-time data of TBM tunnelling.

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2023 Jun 27

Li X, Wu LJ, Wang YJ

452. Spatial patterns of climate change and associated climate hazards in Northwest China.

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2023 Jun 27

Chi H, Wu Y, Zheng H

453. Metabolomic and gut microbiome profiles across the spectrum of community-based COVID and non-COVID disease.

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2023 Jun 27

Österdahl MF(#), Whiston R(#), Sudre CH

454. New library of phase-change materials with their selection by the Rényi entropy method.

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2023 Jun 27

Kulish V, Aslfattahi N, Schmirler M

455. Evaluation of the MC3R gene pertaining to body weight and height regulation and puberty development.

Sci Rep

2023 Jun 27

Zheng Y, Rajcsanyi LS, Peters T

456. Numerical optimization and performance evaluation of ZnPC:PC70BM based dye-sensitized solar cell.

Sci Rep

2023 Jun 27

Nowsherwan GA, Iqbal MA, Rehman SU

457. Drosophila mutants lacking the glial neurotransmitter-modifying enzyme Ebony exhibit low neurotransmitter levels and altered behavior.

Sci Rep

2023 Jun 27

Pantalia M(#), Lin Z(#), Tener SJ(#)

458. Machine learning-based somatic variant calling in cell-free DNA of metastatic breast cancer patients using large NGS panels.

Sci Rep

2023 Jun 27

Jongbloed EM, Jansen MPHM, de Weerd V

459. SSN2V: unsupervised OCT denoising using speckle split.

Sci Rep

2023 Jun 27

Schottenhamml J, Würfl T, Ploner SB

460. Detecting and characterizing special nuclear material for nuclear nonproliferation applications.

Sci Rep

2023 Jun 27

Pozzi SA, He Z, Hutchinson J

461. A semi-empirical approach to calibrate simulation models for semiconductor devices.

Sci Rep

2023 Jun 27

Jaiswal R, Martínez-Ramón M(#), Busani T(#).

462. Tourism-supported working lands sustain a growing jaguar population in the Colombian Llanos.

Sci Rep

2023 Jun 27

Hyde M, Payán E, Barragan J

Understanding large carnivore demography on human-dominated lands is a priority to inform conservation strategies, yet few studies examine long-term trends. Jaguars (Panthera onca) are one such species whose population trends and survival rates remain unknown across working lands. We integrated nine years of camera trap data and tourist photos to estimate jaguar density, survival, abundance, and probability of tourist sightings on a working ranch and tourism destination in Colombia. We found that abundance increased from five individuals in 2014 to 28 in 2022, and density increased from 1.88 ± 0.87 per 100 km2 in 2014 to 3.80 ± 1.08 jaguars per 100 km2 in 2022. The probability of a tourist viewing a jaguar increased from 0% in 2014 to 40% in 2020 before the Covid-19 pandemic. Our results are the first robust estimates of jaguar survival and abundance on working lands. Our findings highlight the importance of productive lands for jaguar conservation and suggest that a tourism destination and working ranch can host an abundant population of jaguars when accompanied by conservation agreements and conflict interventions. Our analytical model that combines conventional data collection with tourist sightings can be applied to other species that are observed during tourism activities.Entender los patrones demográficos de los grandes carnívoros al interior de paisajes antrópicos es fundamental para el diseño de estrategias de conservación efectivas. En el Neotrópico, el jaguar (Panthera onca) es una de estas especies cuyas tendencias poblacionales y tasas de supervivencia en paisajes productivos son desconocidas. Para entender mejor estas dinámicas, integramos nueve años de fototrampeo junto a fotos de turistas para estimar la densidad, supervivencia, abundancia y probabilidad de avistamiento de esta especie en una finca ganadera y destino turístico en Colombia. Entre 2014 y 2022 encontramos que la abundancia incrementó de cinco a 28 individuos y la densidad de 1.88 ± 0.87 jaguares/ 100 km2 a 3.80 ± 1.08 jaguares/ 100 km2. La probabilidad de avistamiento por turistas aumentó de 0% en 2014 a 40% en 2020 antes de la pandemia del Covid-19. Nuestros resultados presentan las primeras estimaciones robustas de abundancia y supervivencia de este felino en paisajes antrópicos dónde el manejo de sistemas productivos combinados con turismo e intervenciones para la mitigación del conflicto puede albergar poblaciones abundantes de jaguares, demostrando su importancia para la conservación de esta especie. Nuestro modelo, al combinar datos convencionales con avistamientos, podría ser aplicado a otras especies observadas durante actividades turísticas.

463. Shotgun proteomics identification of proteins expressed in the Descemet's membrane of patients with Fuchs endothelial corneal dystrophy.

Sci Rep

2023 Jun 27

Nakagawa T, Okumura N, Ikegawa M

464. Subjectively intense odor does not affect dream emotions during rapid eye movement sleep.

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2023 Jun 27

Okabe S, Abe T.

465. In-orbit demonstration of a re-trainable machine learning payload for processing optical imagery.

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2023 Jun 27

Mateo-Garcia G, Veitch-Michaelis J, Purcell C

466. Association of quantitative analysis of intratumoral reduced E-cadherin expression with lymph node metastasis and prognosis in patients with breast cancer.

Sci Rep

2023 Jun 27

Meng X, Morita M, Kuba S

467. Social influence makes outlier opinions in online reviews offer more helpful information.

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2023 Jun 27

Yang K, Fujisaki I, Ueda K.

468. Overwintering and breeding patterns of monarch butterflies (Danaus plexippus) in coastal plain habitats of the southeastern USA.

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2023 Jun 27

Kendrick MR, McCord JW.

469. Electrochemical sensor based on the synergy between Cucurbit[8]uril and 2D-MoS(2) for enhanced melatonin quantification.

Sci Rep

2023 Jun 27

Martínez-Moro R, Del Pozo M, Vázquez L

470. Comparing mechanism-based and machine learning models for predicting the effects of glucose accessibility on tumor cell proliferation.

Sci Rep

2023 Jun 27

Yang J, Virostko J, Liu J

471. Fusion of visible and thermal images improves automated detection and classification of animals for drone surveys.

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2023 Jun 27

Krishnan BS, Jones LR, Elmore JA

472. Prevalence and proportion estimate of asymptomatic Plasmodium infection in Asia: a systematic review and meta-analysis.

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2023 Jun 27

Kotepui M, Kotepui KU, Masangkay FR

473. Modeling of mitochondrial genetic polymorphisms reveals induction of heteroplasmy by pleiotropic disease locus 10398A>G.

Sci Rep

2023 Jun 27

Smullen M, Olson MN, Murray LF

474. In-domain versus out-of-domain transfer learning in plankton image classification.

Sci Rep

2023 Jun 27

Maracani A(#), Pastore VP(#), Natale L

Plankton microorganisms play a huge role in the aquatic food web. Recently, it has been proposed to use plankton as a biosensor, since they can react to even minimal perturbations of the aquatic environment with specific physiological changes, which may lead to alterations in morphology and behavior. Nowadays, the development of high-resolution in-situ automatic acquisition systems allows the research community to obtain a large amount of plankton image data. Fundamental examples are the ZooScan and Woods Hole Oceanographic Institution (WHOI) datasets, comprising up to millions of plankton images. However, obtaining unbiased annotations is expensive both in terms of time and resources, and in-situ acquired datasets generally suffer from severe imbalance, with only a few images available for several species. Transfer learning is a popular solution to these challenges, with ImageNet1K being the most-used source dataset for pre-training. On the other hand, datasets like the ZooScan and the WHOI may represent a valuable opportunity to compare out-of-domain and large-scale plankton in-domain source datasets, in terms of performance for the task at hand.In this paper, we design three transfer learning pipelines for plankton image classification, with the aim of comparing in-domain and out-of-domain transfer learning on three popular benchmark plankton datasets. The general framework consists in fine-tuning a pre-trained model on a plankton target dataset. In the first pipeline, the model is pre-trained from scratch on a large-scale plankton dataset, in the second, it is pre-trained on large-scale natural image datasets (ImageNet1K or ImageNet22K), while in the third, a two-stage fine-tuning is implemented (ImageNet [Formula: see text] large-scale plankton dataset [Formula: see text] target plankton dataset). Our results show that an out-of-domain ImageNet22K pre-training outperforms the plankton in-domain ones, with an average boost in test accuracy of around 6%. In the next part of this work, we adopt three ImageNet22k pre-trained Vision Transformers and one ConvNeXt, obtaining results on par (or slightly superior) with the state-of-the-art, corresponding to the usage of CNN models ensembles, with a single model. Finally, we design and test an ensemble of our Vision Transformers and the ConvNeXt, outperforming the state-of-the-art existing works on plankton image classification on the three target datasets. To support scientific community contribution and further research, our implemented code is open-source and available at https://github.com/Malga-Vision/plankton_transfer .

475. Prognostication and risk factor stratification for survival of patients with hepatocellular carcinoma: a nationwide big data analysis.

Sci Rep

2023 Jun 27

Choi JW, Kang S, Lee J

476. Stereotactic body radiation therapy for stage I medically operable non-small cell lung cancer.

Sci Rep

2023 Jun 27

Kocak Uzel E, Bagci Kilic M, Morcali H

477. Multiple factors contribute to flight behaviors during fear conditioning.

Sci Rep

2023 Jun 27

Furuyama T, Imayoshi A, Iyobe T

478. Bedaquiline- and clofazimine- selected Mycobacterium tuberculosis mutants: further insights on resistance driven largely by Rv0678.

Sci Rep

2023 Jun 27

Snobre J(#), Villellas MC(#), Coeck N

Drug-resistant tuberculosis is a serious global health threat. Bedaquiline (BDQ) is a relatively new core drug, targeting the respiratory chain in Mycobacterium tuberculosis (Mtb). While mutations in the BDQ target gene, atpE, are rare in clinical isolates, mutations in the Rv0678 gene, a transcriptional repressor regulating the efflux pump MmpS5-MmpL5, are increasingly observed, and have been linked to worse treatment outcomes. Nevertheless, underlying mechanisms of (cross)-resistance remain incompletely resolved. Our study aims to distinguish resistance associated variants from other polymorphisms, by assessing the in vitro onset of mutations under drug pressure, combined with their impact on minimum inhibitory concentrations (MICs) and on protein stability. For this purpose, isolates were exposed in vitro to sub-lethal concentrations of BDQ or clofazimine (CFZ). Selected colonies had BDQ- and CFZ-MICs determined on 7H10 and 7H11 agar. Sanger sequencing and additional Deeplex Myc-TB and whole genome sequencing (WGS) for a subset of isolates were used to search for mutations in Rv0678, atpE and pepQ. In silico characterization of relevant mutations was performed using computational tools. We found that colonies that grew on BDQ medium had mutations in Rv0678, atpE or pepQ, while CFZ-exposed isolates presented mutations in Rv0678 and pepQ, but none in atpE. Twenty-eight Rv0678 mutations had previously been described among in vitro selected mutants or in patients' isolates, while 85 were new. Mutations were scattered across the Rv0678 gene without apparent hotspot. While most Rv0678 mutations led to an increased BDQ- and/or CFZ-MIC, only a part of them surpassed the critical concentration (69.1% for BDQ and 87.9% for CFZ). Among the mutations leading to elevated MICs for BDQ and CFZ, we report a synonymous Val1Val mutation in the Rv0678 start codon. Finally, in silico characterization of Rv0678 mutations suggests that especially the C46R mutant may render Rv0678 less stable.

479. Suspended hydrogel culture as a method to scale up intestinal organoids.

Sci Rep

2023 Jun 27

Co JY, Klein JA, Kang S

480. Initial study on an expert system for spine diseases screening using inertial measurement unit.

Sci Rep

2023 Jun 27

Pelc M(#), Vilimkova Kahankova R(#), Blaszczyszyn M(#)

481. Stability bearing capacity of concrete filled steel tubular columns subjected to long-term load.

Sci Rep

2023 Jun 27

Lai X, Gao H, Yang Z

482. A tunnel coaxial 3D hyperspectral scanning system for underground mine investigation.

Sci Rep

2023 Jun 27

Baik H, Son YS, Kim KE.

483. Effect of silver nanoparticles on tropane alkaloid production of transgenic hairy root cultures of Hyoscyamus muticus L. and their antimicrobial activity.

Sci Rep

2023 Jun 27

Abdelkawy AM, Alshammari SO, Hussein HA

484. Bioinformatics analysis and reveal potential crosstalk genetic and immune relationships between atherosclerosis and periodontitis.

Sci Rep

2023 Jun 27

Dong W, Gong Y, Yang B

485. Antimicrobial action and chemical and physical properties of CuO-doped engineered cementitious composites.

Sci Rep

2023 Jun 27

Ślosarczyk A, Klapiszewska I, Parus A

486. Maternal exposure to childhood maltreatment and adverse birth outcomes.

Sci Rep

2023 Jun 27

Keenan-Devlin LS, Borders AEB, Freedman A

Exposure to traumatic events during pregnancy may influence pregnancy and birth outcomes. Growing evidence suggests that exposure to traumatic events well before pregnancy, such as childhood maltreatment (CM), also may influence the course of pregnancy and risk of adverse birth outcomes. We aimed to estimate associations between maternal CM exposure and small-for-gestational-age birth (SGA) and preterm birth (PTB) in a diverse US sample, and to examine whether common CM-associated health and behavioral sequelae either moderate or mediate these associations. The Measurement of Maternal Stress (MOMS) Study was a prospective cohort study that enrolled 744 healthy English-speaking participants ≥ 18 years with a singleton pregnancy, who were < 21 weeks at enrollment, between 2013 and 2015. CM was measured via the Childhood Trauma Questionnaire (CTQ) and participants above the moderate/severe cut-off for any of the five childhood abuse and neglect scales were assigned to the CM-exposed group. Common CM-associated health (obesity, depressive symptoms, hypertensive disorders) and behavioral (substance use) sequelae were obtained from standardized questionnaires and medical records. The main outcomes included PTB (gestational age < 37 weeks at birth) and SGA (birthweight < 10%ile for gestational age) abstracted from the medical record. Multivariable logisitic regression was used to test associations between CM, sequeale, and birth outcomes, and both moderation and mediation by CM-related sequelae were tested. Data were available for 657/744 participants. Any CM exposure was reported by 32% of participants. Risk for SGA birth was 61% higher among those in the CM group compared to the non-CM group (14.1% vs. 7.6%), and each subsequent form of CM that an individual was exposed to corresponded with a 27% increased risk for SGA (aOR 1.27, 95% CI 1.05, 1.53). There was no significant association between CM and PTB (9.3% vs. 13.0%, aOR 1.07, 95% CI 0.58, 1.97). Of these sequelae only hypertensive disorders were associated with both CM and SGA and hypertensive disorders of pregnancy did not mediate the association between CM and SGA. Our findings indicate that maternal CM exposure is associated with increased risk for SGA birth and highlight the importance of investigating the mechanisms whereby childhood adversity sets the trajectory for long-term and intergenerational health issues.

487. Molecular characterization and transcriptional response to TiO(2)-GO nanomaterial exposure of two molt-related genes in the juvenile prawn, Macrobrachium rosenbergii.

Sci Rep

2023 Jun 27

Guo Z, Xu L, Wang W

488. Effects of pore size, water content, and oxygen-containing functional groups on oxygen adsorption in bituminous coal.

Sci Rep

2023 Jun 26

Ren Z, Wang D, Qin Z

489. The impact of sarcopenia on nutritional status in elderly patients with gastrointestinal tumors.

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2023 Jun 26

Ai D, Ding N, Wu H.

This study aimed to analyze the impact of sarcopenia on nutritional status in elderly patients with gastrointestinal tumors. We conducted a study of 146 elderly patients with gastrointestinal tumors in our hospital from January 2020 to June 2022. Patients enrolled were divided into normal nutritional status group (80 patients) and high nutritional risk group (66 patients) according to their nutritional status. The clinical information and nutritional status of the two groups were compared and analyzed. Multivariate logistic regression was done to analyze the risk factors of nutritional status in elderly patients with gastrointestinal tumors; and receiver operating characteristic (ROC) curve was used to evaluate the predictive value of sarcopenia on nutritional status in elderly patients with gastrointestinal tumors. Malnutrition was present in 66 (45.21%) of 146 elderly patients with gastrointestinal cancer. There was no significant difference in gender, age, and tumor location between the two groups (P > 0.05). However, statistically significant difference was observed between the two groups in terms of BMI, tumor staging, calf circumference, the third lumbar vertebra skeletal muscle index (L3-SMI), muscle strength, 6 m walking speed, short physical performance battery (SPPB) score, PG-SGA score, and sarcopenia (p < 0.05). The independent variables were set as BMI (≤ 21.27 kg/cm2), tumor staging (stage II to III), calf circumference (male: ≤ 30.01 cm, female: ≤ 29.37 cm), L3-SMI (male: ≤ 41.29 cm2/m2, female: ≤ 34.29 cm2/m2), muscle strength (male: ≤ 22.32 kg, female: ≤ 16.39 kg), 6 m walking speed (≤ 0.89 m/s), SPPB score (≤ 8.67 points), PG-SGA score (> 3 points), and sarcopenia. The dependent variable was malnutrition in elderly patients with gastrointestinal tumors. A univariate logistic regression analysis was conducted, showing that the influencing factors for malnutrition in elderly patients with gastrointestinal tumors were L3-SMI (male: ≤ 41.29 cm2/m2; female: ≤ 34.29 cm2/m2), muscle strength (male: ≤ 22.32 kg; female: ≤ 16.39 kg), BMI (≤ 21.27 kg/cm2), SPPB score (≤ 8.67 points), PG-SGA score (> 3 points) and sarcopenia. Moreover, the independent variables were set as L3-SMI (male: ≤ 41.29 cm2/m2; female: ≤ 34.29 cm2/m2), muscle strength (male: ≤ 22.32 kg; female: ≤ 16.39 kg), BMI (≤ 21.27 kg/cm2), SPPB score (≤ 8.67 points), PG-SGA score (> 3 points), and sarcopenia. The dependent variable was malnutrition in elderly patients with gastrointestinal tumors. The multivariate logistic regression analysis revealed that the influencing factors of malnutrition in elderly patients with gastrointestinal tumors were BMI (≤ 21.27 kg/cm2) and sarcopenia. The ROC curve of BMI (≤ 21.27 kg/cm2) and sarcopenia, and the area under the curve (AUC) of BMI (≤ 21.27 kg/cm2) and sarcopenia predicting malnutrition in elderly gastrointestinal cancer patients were 0.681 and 0.881, respectively. The influencing factors of malnutrition in elderly patients with gastrointestinal tumors were BMI (≤ 21.27 kg/cm2) and sarcopenia, and the two factors may exert predictive value in terms of the occurrence of malnutrition in such patients.

490. Integrated bioinformatics and wet-lab analysis revealed cell adhesion prominent genes CDC42, TAGLN and GSN as prognostic biomarkers in colonic-polyp lesions.

Sci Rep

2023 Jun 26

Tabatabaei ES(#), Mazloomnejad R(#), Rejali L

Colorectal cancers are derived from intestinal polyps. Normally, alterations in cell adhesion genes expression cause deviation from the normal cell cycle, leading to cancer development, progression, and invasion. The present study aimed to investigate the elusive expression pattern of CDC42, TAGLN, and GSN genes in patients with high and low-risk polyp samples, and also colorectal cancer patients and their adjacent normal tissues. In upcoming study, 40 biopsy samples from Taleghani Hospital (Tehran, Iran) were collected, consisting of 20 colon polyps and 20 paired adjacent normal tissues. The expression of the nominated genes CDC42, TAGLN, and GSN was analyzed using quantitative polymerase chain reaction (Q-PCR) and relative quantification was determined using the 2-ΔΔCt method. ROC curve analysis was performed to compare high-risk and low-risk polyps for the investigated genes. The expression of adhesion molecule genes was also evaluated using TCGA data and the correlation between adhesion molecule gene expression and immunophenotype was analyzed. The role of mi-RNAs and lncRNAs in overexpression of adhesion molecule genes was studied. Lastly, GO and KEGG were performed to identify pathways related to adhesion molecule genes expression in healthy, normal adjacent, and COAD tissues. The results showed that the expression patterns of these genes were significantly elevated in high-risk adenomas compared to low-risk polyps and normal tissues and were associated with various clinicopathological characteristics. The estimated AUC for CDC42, TAGLN, and GSN were 0.87, 0.77, and 0.80, respectively. The study also analyzed COAD cancer patient data and found that the selected gene expression in cancer patients was significantly reduced compared to high-risk polyps and healthy tissues. Survival analysis showed that while the expression level of the GSN gene had no significant relationship with survival rate, the expression of CDC42 and TAGLN genes did have a meaningful relationship, but with opposite effects, suggesting the potential use of these genes as diagnostic or prognostic markers for colorectal cancer. The present study's findings suggest that the expression pattern of CDC42, TAGLN, and GSN genes was significantly increased during the transformation of normal tissue to polyp lesions, indicating their potential as prognostic biomarkers for colorectal polyp development. Further results provide valuable insights into the potential use of these genes as diagnostic or prognostic markers for colorectal cancer. However, further studies are necessary to validate these findings in larger cohorts and to explore the underlying mechanisms of these genes in the development and progression of colorectal cancer.

491. A diagnostic model for differentiating tuberculous spondylitis from pyogenic spondylitis: a retrospective case-control study.

Sci Rep

2023 Jun 26

Liu YX, Lei F, Zheng LP

The purpose of this study was to describe and compare the clinical data, laboratory examination and imaging examination of tuberculous spondylitis (TS) and pyogenic spondylitis (PS), and to provide ideas for diagnosis and treatment intervention. The patients with TS or PS diagnosed by pathology who first occurred in our hospital from September 2018 to November 2021 were studied retrospectively. The clinical data, laboratory results and imaging findings of the two groups were analyzed and compared. The diagnostic model was constructed by binary logistic regression. In addition, an external validation group was used to verify the effectiveness of the diagnostic model. A total of 112 patients were included, including 65 cases of TS with an average age of 49 ± 15 years, 47 cases of PS with an average of 56 ± 10 years. The PS group had a significantly older age than the TS group (P = 0.005). In laboratory examination, there were significant differences in WBC, neutrophil (N), lymphocyte (L), ESR, CRP, fibrinogen (FIB), serum albumin (A) and sodium (Na). The difference was also statistically significant in the comparison of imaging examinations at epidural abscesses, paravertebral abscesses, spinal cord compression, involvement of cervical, lumbar and thoracic vertebrae. This study constructed a diagnostic model, which was Y (value of TS > 0.5, value of PS < 0.5) = 1.251 * X1 (thoracic vertebrae involved = 1, thoracic vertebrae uninvolved = 0) + 2.021 * X2 (paravertebral abscesses = 1, no paravertebral abscess = 0) + 2.432 * X3 (spinal cord compression = 1, no spinal cord compression = 0) + 0.18 * X4 (value of serum A)-4.209 * X5 (cervical vertebrae involved = 1, cervical vertebrae uninvolved = 0)-0.02 * X6 (value of ESR)-0.806 * X7 (value of FIB)-3.36. Furthermore, the diagnostic model was validated using an external validation group, indicating a certain value in diagnosing TS and PS. This study puts forward a diagnostic model for the diagnosis of TS and PS in spinal infection for the first time, which has potential guiding value in the diagnosis of them and provides a certain reference for clinical work.

492. Cerebral abnormalities in HIV-infected individuals with neurocognitive impairment revealed by fMRI.

Sci Rep

2023 Jun 26

Chen PP(#), Wei XY(#), Tao L

Although the combination antiretroviral treatment (cART) has considerably lowered the risk of HIV associated dementia (HAD), the incidence of neurocognitive impairments (NCI) has not decreased likely due to the insidious and slow progressive nature of HIV infection. Recent studies showed that the resting-state functional magnetic resonance imaging (rs-fMRI) is a prominent technique in helping the non-invasive analysis of neucognitive impairment. Our study is to explore the neuroimaging characteristics among people living with HIV (PLWH) with or without NCI in terms of cerebral regional and neural network by rs-fMRI, based on the hypothesis that HIV patients with and without NCI have independent brain imaging characteristics. 33 PLWH with NCI and 33 PLWH without NCI, recruited from the Cohort of HIV-infected associated Chronic Diseases and Health Outcomes, Shanghai, China (CHCDO) which was established in 2018, were categorized into the HIV-NCI and HIV-control groups, respectively, based on Mini-Mental State Examination (MMSE) results. The two groups were matched in terms of sex, education and age. Resting-state fMRI data were collected from all participants to analyze the fraction amplitude of low-frequency fluctuation (fALFF) and functional connectivity (FC) to assess regional and neural network alterations in the brain. Correlations between fALFF/FC values in specific brain regions and clinical characteristics were also examined. The results showed increased fALFF values in the bilateral calcarine gyrus, bilateral superior occipital gyrus, left middle occipital gyrus, and left cuneus in the HIV-NCI group compared to the HIV-control group. Additionally, increased FC values were observed between the right superior occipital gyrus and right olfactory cortex, bilateral gyrus rectus, and right orbital part of the middle frontal gyrus in the HIV-NCI group. Conversely, decreased FC values were found between the left hippocampus and bilateral medial prefrontal gyrus, as well as bilateral superior frontal gyrus. The study concluded that abnormal spontaneous activity in PLWH with NCI primarily occurred in the occipital cortex, while defects in brain networks were mostly associated with the prefrontal cortex. The observed changes in fALFF and FC in specific brain regions provide visual evidence to enhance our understanding of the central mechanisms underlying the development of cognitive impairment in HIV patients.

493. Different intrauterine environments and children motor development in the first 6 months of life: a prospective longitudinal cohort.

Sci Rep

2023 Jun 26

Costa Wiltgen A, Valentini NC, Beltram Marcelino T

494. Cancer survival analysis and spatial distribution during 2014-2016 in Shandong Province, China.

Sci Rep

2023 Jun 26

Jiang F, Fu Z, Lu Z

495. Gravitational friction from d'Alembert's principle.

Sci Rep

2023 Jun 26

Ortiz C, Khatiwada RS.

496. Fe(3)O(4)@C@MCM41-guanidine core-shell nanostructures as a powerful and recyclable nanocatalyst with high performance for synthesis of Knoevenagel reaction.

Sci Rep

2023 Jun 26

Barzkar A, Beni AS.

497. Dose-effects in behavioural responses of moths to light in a controlled lab experiment.

Sci Rep

2023 Jun 26

Jägerbrand A, Andersson P, Nilsson Tengelin M.

498. Hypertrophic cardiomyopathy in purpose-bred cats with the A31P mutation in cardiac myosin binding protein-C.

Sci Rep

2023 Jun 26

Stern JA, Rivas VN, Kaplan JL

499. Modelling COVID-19 pandemic control strategies in metropolitan and rural health districts in New South Wales, Australia.

Sci Rep

2023 Jun 26

Rahman A, Kuddus MA, Ip RHL

COVID-19 remains a significant public health problem in New South Wales, Australia. Although the NSW government is employing various control policies, more specific and compelling interventions are needed to control the spread of COVID-19. This paper presents a modified SEIR-X model based on a nonlinear ordinary differential equations system that considers the transmission routes from asymptomatic (Exposed) and symptomatic (Mild and Critical) individuals. The model is fitted to the corresponding cumulative number of cases in metropolitan and rural health districts of NSW reported by the Health Department and parameterised using the least-squares method. The basic reproduction number [Formula: see text], which measures the possible spread of COVID-19 in a population, is computed using the next generation operator method. Sensitivity analysis of the model parameters reveals that the transmission rate had an enormous influence on [Formula: see text], which may be an option for controlling this disease. Two time-dependent control strategies, namely preventive (it refers to effort at inhibiting the virus transmission and prevention of case development from Exposed, Mild, Critical, Non-hospitalised and Hospitalised population) and management (it refers to enhance the management of Non-hospitalised and Hospitalised individuals who are infected by COVID-19) measures, are considered to mitigate this disease's dynamics using Pontryagin's maximum principle. The most sensible control strategy is determined through the cost-effectiveness analysis for the metropolitan and rural health districts of NSW. Our findings suggest that of the single intervention strategies, enhanced preventive strategy is more cost-effective than management control strategy, as it promptly reduces COVID-19 cases in NSW. In addition, combining preventive and management interventions simultaneously is found to be the most cost-effective. Alternative policies can be implemented to control COVID-19 depending on the policymakers' decisions. Numerical simulations of the overall system are performed to demonstrate the theoretical outcomes.

500. Improved psychosocial measures associated with physical activity may be explained by alterations in brain-gut microbiome signatures.

Sci Rep

2023 Jun 26

Guan M, Dong TS, Subramanyam V

501. Cytokine profiles in adults with imported malaria.

Sci Rep

2023 Jun 26

de Roquetaillade C, Laouenan C, Mira JP

The increase in worldwide travel is making imported malaria a growing health concern in non-endemic countries. Most data on the pathophysiology of malaria come from endemic areas. Little is known about cytokine profiles during imported malaria. This study aimed at deciphering the relationship between cytokine host response and malaria severity among imported cases in France. This study reports cytokine profiles in adults with Plasmodium falciparum malaria included in the PALUREA prospective study conducted between 2006 and 2010. The patients were classified as having uncomplicated malaria (UM) or severe malaria (SM), with this last further categorized as very severe malaria (VSM) or less severe malaria (LSM). At hospital admission, eight blood cytokines were assayed in duplicate using Luminex® technology: interleukin (IL)-1α, IL-1β, IL-2, IL-4, IL-10, tumor necrosis factor (TNF)α, interferon (IFN)γ, and macrophage migration inhibitory factor (MIF). These assays were repeated on days 1 and 2 in the SM group. Of the 278 patients, 134 had UM and 144 SM. At hospital admission, over half the patients had undetectable levels of IL-1α, IL-1β, IL-2, IL-4, IFNγ, and TNFα, while IL-10 and MIF were significantly higher in the SM vs. the UM group. Higher IL-10 was significantly associated with higher parasitemia (R = 0.32 [0.16-0.46]; P = 0.0001). In the SM group, IL-10 elevation persisting from admission to day 2 was significantly associated with subsequent nosocomial infection. Of eight tested cytokines, only MIF and IL-10 were associated with disease severity in adults with imported P. falciparum malaria. At admission, many patients had undetectable cytokine levels, suggesting that circulating cytokine assays may not be helpful as part of the routine evaluation of adults with imported malaria. Persisting high IL-10 concentration was associated with subsequent nosocomial infection, suggesting its possible interest in immune monitoring of most severe patients.

502. Kinematic coordinations capture learning during human-exoskeleton interaction.

Sci Rep

2023 Jun 26

Ghonasgi K, Mirsky R, Bhargava N

503. Phenotypic and molecular characterization of beta-lactam resistant Multidrug-resistant Enterobacterales isolated from patients attending six hospitals in Northern Nigeria.

Sci Rep

2023 Jun 26

Medugu N, Tickler IA, Duru C

Infections caused by multi-drug resistant Enterobacterales (MDR-E) are difficult to treat and cause significant mortality, especially in developing countries. This study characterized the phenotypic and genotypic profiles of 49 randomly selected beta-lactam resistant MDR-E previously isolated from patients being managed in hospitals in Nigeria using whole genome sequencing. The study isolates exhibited 85.5% resistance to 3rd generation cephalosporins and 65.3% resistance to carbapenems. The blaTEM-1B (29, 59.2%), blaCTX-M-15 (38, 77.6%), and blaNDM-1 (17, 51.5%) were the most common penicillinase, ESBL, and carbapenem resistant genes across isolates, respectively. Seventeen (45%) of blaCTX-M-15 was carried on the insertion sequence ISEc9 while blaNDM-1 (11, 64.7%) were associated with ISEc33. None of the 21 plasmids detected were associated with β-lactamase genes. Higher resistance rates were found in E. coli ST-88 (n = 2) and the high-risk ST-692 (n = 2). For Klebsiella species, the high-risk clones ST-476 (n = 8) and ST-147 (n = 3) predominated and had higher phenotypic resistance rates and higher number of AMR genes. The mechanisms and pattern of antibiotic resistance differ from patterns previously described with isolates harbouring a wide range of AMRGs. The detection of several chromosomally mediated carbapenemases in our study also represents a significant finding that warrants further investigation to better understand its' implications for clinical practice and public health. The selected MDR-Es were found to be pan-susceptible to tigecycline and had very low resistance to fosfomycin, suggesting a potential for these as empiric treatments. A surveillance approach incorporating both conventional laboratory techniques and modern molecular techniques is essential for the comprehensive characterization of the emergence and dissemination of antimicrobial resistance in Enterobacterales infections within Nigeria.

504. Sperm-fluid-cell interplays in the bovine oviduct: glycosaminoglycans modulate sperm binding to the isthmic reservoir.

Sci Rep

2023 Jun 26

Mahé C, Pranomphon T, Reynaud K

505. Effectiveness of a probiotic combination on the neurodevelopment of the very premature infant.

Sci Rep

2023 Jun 26

Baucells BJ(#), Sebastiani G(#), Herrero-Aizpurua L

506. Incidence of cleft lip and palate, and epidemiology of perinatal deaths related to cleft lip and palate in Hunan Province, China, 2016-2020.

Sci Rep

2023 Jun 26

Zhou X, Jiang Y, Fang J

This study aimed to analyze the epidemiological characteristics of cleft lip and/or palate (CL/P) and CL/P-related perinatal deaths, provide some information for intervention programs to reduce the incidence of CL/P and provide clues for future researchers. Data were obtained from the Birth Defects Surveillance System in Hunan Province, China, 2016-2020. Incidences of CL/P [number of cases per 1000 fetuses (births and deaths at 28 weeks of gestation and beyond)] with 95% confidence intervals (CI) were calculated by residence, gender, maternal age, year, and major types [cleft lip only (CL), cleft palate only (CP), and cleft lip with palate (CLP)]. Crude odds ratios (ORs) were calculated to examine the association of each maternal characteristic with CL/P. Pearson chi-square tests (χ2) were used to examine the association of each maternal characteristic with CL/P-related perinatal deaths. A total of 847,755 fetuses were registered, and 14,459 birth defects were identified, including 685 CL/P (accounted for 4.74% of all birth defects). CL, CP, and CLP accounted for 24.67% (169 cases), 36.79% (252 cases), and 38.54% (264 cases) of all CL/P, respectively. The incidence of CL/P was 0.81‰ (95%CI 0.75-0.87). The incidence of CL was 0.20‰ (95%CI 0.17-0.23) (169 cases), of CP was 0.30‰ (95%CI 0.26-0.33) (252 cases), and of CLP was 0.31‰ (95%CI 0.27-0.35) (264 cases). CL was more common in males than females (0.24‰ vs. 0.15‰, OR = 1.62, 95%CI 1.18-2.22). CP was more common in urban than rural (0.36‰ vs. 0.25‰, OR = 1.43, 95%CI 1.12-1.83), and less common in males than females (0.22‰ vs. 0.38‰, OR = 0.59, 95%CI 0.46-0.75). CLP was more common in males than females (0.35‰ vs. 0.26‰, OR = 1.36, 95%CI 1.06-1.74). Compared to mothers 25-29 years old, mothers < 20 years old were risk factors for CLP (OR = 3.62, 95%CI 2.07-6.33) and CL/P (OR = 1.80, 95%CI 1.13-2.86), and mothers ≥ 35 years old was a risk factor for CLP (OR = 1.43, 95%CI 1.01-2.02). CL/P-related perinatal deaths accounted for 24.96% (171/685) of all CL/P, of which 90.64% (155/171) were terminations of pregnancy. Rural residents, low income, low maternal age, and early prenatal diagnosis are risk factors for perinatal death. In conclusion, we found that CP was more common in urban areas and females, CL and CLP were more common in males, and CL/P was more common in mothers < 20 or ≥ 35 years old. In addition, most CL/P-related perinatal deaths were terminations of pregnancy. CL/P-related perinatal deaths were more common in rural areas, and the proportion of CL/P-related perinatal deaths decreased with the increase in maternal age, parity, and per-capita annual income. Several mechanisms have been proposed to explain these phenomena. Our study is the first systematic research on CL/P and CL/P-related perinatal deaths based on birth defects surveillance. It is significant for intervention programs to prevent CL/P and CL/P-related perinatal deaths. As well, more epidemiological characteristics of CL/P (such as the location of CL/P) and approaches to reduce CL/P-related perinatal deaths need to be studied in the future.

507. Radiological feature heterogeneity supports etiological diversity among patient groups in Meniere's disease.

Sci Rep

2023 Jun 26

Bächinger D, Filidoro N, Naville M

508. Polarization-controlled nonlinear computer-generated holography.

Sci Rep

2023 Jun 26

Ackermann L, Roider C, Cvecek K

509. Serum caffeine concentrations in preterm infants: a retrospective study.

Sci Rep

2023 Jun 26

Sugino M, Kuboi T, Noguchi Y

510. Clinical efficacy and imaging analysis for the surgical treatment of thoracolumbar infections in elderly patients: a retrospective study.

Sci Rep

2023 Jun 26

Zhong Y(#), Tang B(#), Zhang Z

Few reports have been conducted to comparing surgical results and safety evaluations between the different types of infections in geriatric patients with thoracolumbar infections. The aim of this study is to investigate the safety and efficacy of surgical treatment for thoracolumbar infections in elderly patients. 21 patients with pyogenic spondylodiscitis (PS) and 26 patients with tuberculous spondylodiscitis (TS) were enrolled in the study. All patients were treated using one-stage posterior debridement, decompression, and pedicle screw fixation. Comparison of operative safety parameters between the two groups. Clinical efficacy was evaluated using visual analogue scale (VAS) score, the American Spinal Injury Association (ASIA) grade, the short form (SF)-36 survey and Oswestry disability index (ODI) to determine patient quality of life pre- and post-operatively. Hospitalisation and intensive care unit duration in the PS group were significantly shorter than in the TS group (P < 0.05). The total incidence of post-operative complications for both groups was 44.7%. More complications occurred in the TS group, but the difference was not significant. The scores of VAS, ODI and SF-36 of all 47 patients were significantly improved compared with those before operation.The VAS and SF-36 scores (physical component) were significantly better in the PS group 6 months post-operatively, and the SF-36 (mental component) scores were significantly better in the PS group at the 1-year follow-up. Neurological status in both groups improved post-operatively, and 83% of patients reported satisfactory results based on the modified MacNab standard. Imaging results showed that bone graft fusion improved in both groups at 6 months, 1 year and at the final follow-up. One-stage posterior debridement, decompression, interbody fusion, and internal fixation can be considered a safe and effective method of treating spinal infections in the elderly. This method can improve nerve function, reconstruct spinal stability, and enhance the quality of life of elderly patients. Both PS and TS who underwent surgery achieve similar clinical and radiological results.

511. Evaluation of the orally bioavailable 4-phenylbutyrate-tethered trichostatin A analogue AR42 in models of spinal muscular atrophy.

Sci Rep

2023 Jun 26

Lumpkin CJ(#), Harris AW(#), Connell AJ(#)

512. The value of non-contrast chest CT in the prediction of myocardial injury in patients with the COVID-19 Omicron variant.

Sci Rep

2023 Jun 26

Zhong Y, Sun Z, Xu P

The Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Omicron variant associated myocardial injury seriously affected the patient's health. Chest computed tomography (CT) is an essential imaging diagnostic tool for evaluating lung diseases in these patients, but its value in the diagnosis of myocardial injury remains unknown. The purpose of this study was to evaluate the lung lesions in patients with Omicron infection with or without myocardial injury, and to evaluate the predictive value of non-contrast chest CT in such patients with myocardial injury. We enrolled 122 consecutive hospitalized patients with laboratory-confirmed coronavirus disease 2019 (COVID-19) for non-contrast chest CT examination. These patients were divided into two groups according to whether myocardial injury occurred. Myocardial injury was defined as a Troponin I level above the 99th-percentile upper reference limit (0.04 ng/mL). The imaging manifestations of the patients' lungs were evaluated. Myocardial CT value, left atrium (LA) size, long diameter of left ventricular (LV), and cardiothoracic ratio (CTR) were recorded. Multivariate logistic analysis was performed to identify the predictive factors associated with myocardial injury. Of 122 patients, 61 patients (50%) had myocardial injury. Compared with patients without myocardial injury, there was worse NYHA class, more critical patients, higher incidence of bronchial meteorology, larger area and percentage of lung lesions, diameters of LA, and lower myocardial CT value in the myocardial injury group (P < 0.05). Troponin I concentration in patients with myocardial injury group showed negative correlation with myocardial CT value (r = - 0.319, P = 0.012). The multivariable logistic regression analysis showed that disease severity status (OR 2.279; 95% CI 1.247-4.165, P = 0.007), myocardial CT value (OR 0.849; 95% CI 0.752-0.958, P = 0.008), neutrophil count (OR 1.330; 95% CI 1.114-1.587, P = 0.002) were independent predictors of myocardial injury. The discrimination of the model was good (C-statistic = 0.845, 95% CI 0.775-0.914) and well calibrated with a Hosmer-Lemeshow test for goodness of fit (P = 0.476). Patients infected with Omicron with myocardial injury had more severe lung disease than those without myocardial injury. Non-contrast chest CT can be a useful method of detection of myocardial injury in Omicron infection patients.

513. The copper chelator ammonium tetrathiomolybdate inhibits the progression of experimental endometriosis in TNFR1-deficient mice.

Sci Rep

2023 Jun 26

Conforti RA, Delsouc MB, Zabala AS

514. Exploring the potential of Bornean polypore fungi as biological control agents against pathogenic Ganoderma boninense causing basal stem rot in oil palm.

Sci Rep

2023 Jun 26

Darlis D(#), Jalloh MB, Chin CFS

515. Association of post-smoking cessation changes in fasting serum glucose with changes in predicted fatty liver score.

Sci Rep

2023 Jun 26

Han S(#), Jeong S(#), Ahn JC

516. PET-validated EEG-machine learning algorithm predicts brain amyloid pathology in pre-dementia Alzheimer's disease.

Sci Rep

2023 Jun 26

Kim NH, Park U, Yang DW

Developing reliable biomarkers is important for screening Alzheimer's disease (AD) and monitoring its progression. Although EEG is non-invasive direct measurement of brain neural activity and has potentials for various neurologic disorders, vulnerability to noise, difficulty in clinical interpretation and quantification of signal information have limited its clinical application. There have been many research about machine learning (ML) adoption with EEG, but the accuracy of detecting AD is not so high or not validated with Aβ PET scan. We developed EEG-ML algorithm to detect brain Aβ pathology among subjective cognitive decline (SCD) or mild cognitive impairment (MCI) population, and validated it with Aβ PET. 19-channel resting-state EEG and Aβ PET were collected from 311 subjects: 196 SCD(36 Aβ +, 160 Aβ -), 115 MCI(54 Aβ +, 61Aβ -). 235 EEG data were used for training ML, and 76 for validation. EEG features were standardized for age and sex. Multiple important features sets were selected by 6 statistics analysis. Then, we trained 8 multiple machine learning for each important features set. Meanwhile, we conducted paired t-test to find statistically different features between amyloid positive and negative group. The best model showed 90.9% sensitivity, 76.7% specificity and 82.9% accuracy in MCI + SCD (33 Aβ +, 43 Aβ -). Limited to SCD, 92.3% sensitivity, 75.0% specificity, 81.1% accuracy (13 Aβ +, 24 Aβ -). 90% sensitivity, 78.9% specificity and 84.6% accuracy for MCI (20 Aβ +, 19 Aβ -). Similar trends of EEG power have been observed from the group comparison between Aβ + and Aβ -, and between MCI and SCD: enhancement of frontal/ frontotemporal theta; attenuation of mid-beta in centroparietal areas. The present findings suggest that accurate classification for beta-amyloid accumulation in the brain based on QEEG alone could be possible, which implies that QEEG is a promising biomarker for beta-amyloid. Since QEEG is more accessible, cost-effective, and safer than amyloid PET, QEEG-based biomarkers may play an important role in the diagnosis and treatment of AD. We expect specific patterns in QEEG could play an important role to predict future progression of cognitive impairment in the preclinical stage of AD. Further feature engineering and validation with larger dataset is recommended.

517. Deep neural network-based analysis of the impact of ambidextrous innovation and social networks on firm performance.

Sci Rep

2023 Jun 26

Zhang X, Quah CH, Nazri Bin Mohd Nor M.

518. Neuropsychological deficits in patients with persistent COVID-19 symptoms: a systematic review and meta-analysis.

Sci Rep

2023 Jun 26

Sobrino-Relaño S, Balboa-Bandeira Y, Peña J

Long-term persistent symptoms of COVID-19 affect 30-80% of patients who have recovered from the disease and may continue for a long time after the disease has been overcome. The duration of these symptoms over time might have consequences that affect different aspects of health, such as cognitive abilities. The main objective of this systematic review and meta-analysis was to objectify the persistent COVID-19 cognitive deficits after acute phase of infection and to summarize the existing evidence. Additionally, we aimed to provide a comprehensive overview to further understand and address the consequences of this disease. Our protocol was registered in PROSPERO (CRD42021260286). Systematic research was conducted in the Web of Science, MEDLINE, PubMed, PsycINFO, Scopus, and Google Scholar databases from January 2020 to September 2021. Twenty-five studies were included, six of which were analyzed for the meta-analysis, and consisted of 175 patients who had recovered from COVID-19 and 275 healthy individuals. Analyses of cognitive performance of post-COVID-19 patients and healthy volunteers were compared using a random-effects model. The results showed an overall medium-high effect size (g = -.68, p = .02) with a 95% CI (-1.05 to -.31), with a significantly moderate level of heterogeneity among studies (Z = 3.58, p < .001; I2 = 63%). The results showed that individuals who had recovered from COVID-19 showed significant cognitive deficits compared to controls. Future studies should carefully assess the long-term progression of cognitive impairments in patients with persistent COVID-19 symptoms, as well as the effectiveness of rehabilitation interventions. Nevertheless, there is an urgent need to know the profile to speed up development of prevention plans as well as specific interventions. Since more information is being obtained and more studies are being conducted on the subject, the need to examine this symptomatology multidisciplinary to achieve greater scientific evidence of its incidence and prevalence has become increasingly clear.

519. A nationwide cross-sectional study on the association of patient-level factors with financial anxiety in the context of chronic medical conditions.

Sci Rep

2023 Jun 26

Hassan AM, Chu CK, Liu J

520. Early Pleistocene cut marked hominin fossil from Koobi Fora, Kenya.

Sci Rep

2023 Jun 26

Pobiner B, Pante M, Keevil T.

521. Co-electrolysis of seawater and carbon dioxide inside a microfluidic reactor to synthesize speciality organics.

Sci Rep

2023 Jun 26

Rarotra S, Singh AK, Mandal TK

522. Early Dalmatian farmers specialized in sheep husbandry.

Sci Rep

2023 Jun 26

Sierra A, Balasse M, Radović S

523. Annealing temperature effects on the size and band gap of ZnS quantum dots fabricated by co-precipitation technique without capping agent.

Sci Rep

2023 Jun 26

Alwany AB, Youssef GM, Samir OM

524. Mother optimization algorithm: a new human-based metaheuristic approach for solving engineering optimization.

Sci Rep

2023 Jun 26

Matoušová I, Trojovský P, Dehghani M

This article's innovation and novelty are introducing a new metaheuristic method called mother optimization algorithm (MOA) that mimics the human interaction between a mother and her children. The real inspiration of MOA is to simulate the mother's care of children in three phases education, advice, and upbringing. The mathematical model of MOA used in the search process and exploration is presented. The performance of MOA is assessed on a set of 52 benchmark functions, including unimodal and high-dimensional multimodal functions, fixed-dimensional multimodal functions, and the CEC 2017 test suite. The findings of optimizing unimodal functions indicate MOA's high ability in local search and exploitation. The findings of optimization of high-dimensional multimodal functions indicate the high ability of MOA in global search and exploration. The findings of optimization of fixed-dimension multi-model functions and the CEC 2017 test suite show that MOA with a high ability to balance exploration and exploitation effectively supports the search process and can generate appropriate solutions for optimization problems. The outcomes quality obtained from MOA has been compared with the performance of 12 often-used metaheuristic algorithms. Upon analysis and comparison of the simulation results, it was found that the proposed MOA outperforms competing algorithms with superior and significantly more competitive performance. Precisely, the proposed MOA delivers better results in most objective functions. Furthermore, the application of MOA on four engineering design problems demonstrates the efficacy of the proposed approach in solving real-world optimization problems. The findings of the statistical analysis from the Wilcoxon signed-rank test show that MOA has a significant statistical superiority compared to the twelve well-known metaheuristic algorithms in managing the optimization problems studied in this paper.

525. Genome-wide discovery of di-nucleotide SSR markers based on whole genome re-sequencing data of Cicer arietinum L. and Cicer reticulatum Ladiz.

Sci Rep

2023 Jun 26

Sari D, Sari H, Ikten C

Simple sequence repeats (SSRs) are valuable genetic markers due to their co-dominant inheritance, multi-allelic and reproducible nature. They have been largely used for exploiting genetic architecture of plant germplasms, phylogenetic analysis, and mapping studies. Among the SSRs, di-nucleotide repeats are the most frequent of the simple repeats distributed throughout the plant genomes. In present study, we aimed to discover and develop di-nucleotide SSR markers by using the whole genome re-sequencing (WGRS) data from Cicer arietinum L. and C. reticulatum Ladiz. A total of 35,329 InDels were obtained in C. arietinum, whereas 44,331 InDels in C. reticulatum. 3387 InDels with 2 bp length were detected in C. arietinum, there were 4704 in C. reticulatum. Among 8091 InDels, 58 di-nucleotide regions that were polymorphic between two species were selected and used for validation. We tested primers for evaluation of genetic diversity in 30 chickpea genotypes including C. arietinum, C. reticulatum, C. echinospermum P.H. Davis, C. anatolicum Alef., C. canariense A. Santos & G.P. Lewis, C. microphyllum Benth., C. multijugum Maesen, C. oxyodon Boiss. & Hohen. and C. songaricum Steph ex DC. A total of 244 alleles were obtained for 58 SSR markers giving an average of 2.36 alleles per locus. The observed heterozygosity was 0.08 while the expected heterozygosity was 0.345. Polymorphism information content was found to be 0.73 across all loci. Phylogenetic tree and principal coordinate analysis clearly divided the accessions into four groups. The SSR markers were also evaluated in 30 genotypes of a RIL population obtained from an interspecific cross between C. arietinum and C. reticulatum. Chi-square (χ2) test revealed an expected 1:1 segregation ratio in the population. These results demonstrated the success of SSR identification and marker development for chickpea with the use of WGRS data. The newly developed 58 SSR markers are expected to be useful for chickpea breeders.

526. Analysis of age-dependent gene-expression in human tissues for studying diabetes comorbidities.

Sci Rep

2023 Jun 26

Guzzi PH, Cortese F, Mannino GC

527. Synthesis of magnetic electroactive nanomotors based on sodium alginate/chitosan and investigation the influence of the external electric field on the mechanism of locomotion.

Sci Rep

2023 Jun 26

Mafakheri F, Asakereh A, Khoee S

528. Remodeled eX vivo muscle engineered tissue improves heart function after chronic myocardial ischemia.

Sci Rep

2023 Jun 26

Cosentino M, Nicoletti C, Valenti V

529. Amino acid positions near the active site determine the reduced activity of human ACOD1 compared to murine ACOD1.

Sci Rep

2023 Jun 26

Chen F(#), Yalcin I(#), Zhao M

530. The persistence of cognitive biases in financial decisions across economic groups.

Sci Rep

2023 Jun 26

Ruggeri K(#), Ashcroft-Jones S(#), Abate Romero Landini G

531. Estimation of maximal lactate steady state using the sweat lactate sensor.

Sci Rep

2023 Jun 26

Muramoto Y, Nakashima D, Amano T

532. The construction of mine water recycling performance evaluation index system under the Internet of Things environment.

Sci Rep

2023 Jun 26

Lei M, Li Y, Zhou N

533. Analysis of survival and prognostic factors of clear cell adenocarcinoma of the prostate: a case-control study for a rare cancer entity.

Sci Rep

2023 Jun 26

Chen S, Song W, Zhang R

Clear cell adenocarcinoma of the prostate (CCPC) is a rare entity compared to acinar carcinoma of the prostate (APC). The survival rate and prognostic factors of CCPC are still unclear and deserve further study. We downloaded data on prostate cancer from the Surveillance, Epidemiology, and End Results database for 1975-2019. After inclusion and exclusion criteria, we compared APC and analyzed cancer-specific mortality (CSM) and overall mortality (OM) in CCPC patients and prognostic risk factors using a propensity score matching (PSM) study and multivariate Cox regression. We included 408,004 cases of APC as a control group and 130 cases of CCPC as a case group. Compared with APC patients, the incidence of CCPC was extremely low, and the median age of diagnosis was older (72.00 years vs. 69.00 years, p < 0.01). In addition, more rates were diagnosed at an earlier stage (1975-1998, 93.1% vs. 50.2%, p < 0.001), more unstaged or unknown stage ratios (87.7% vs. 42.7%, p < 0.001), and more surgical treatments (66.2% vs. 47.6%, p < 0.001), but the prognosis of CCPC patients was worse. After PSM, the median survival time of CCPC patients was shorter (57.50 month vs. 88.00 month, p < 0.01), the rate of CSM was higher (41.5% vs. 27.7%, p < 0.05), and the rate of OM was higher (99.2% vs. 90.8%, p < 0.01). In the adjusted model 2 after PSM, the CSM risk of CCPC patients reached HR 1.76 (95%CI 1.13-2.72), which was 76% higher than that of APC patients (p < 0.05). It was further found that surgical treatment might benefit CSM in CCPC patients (HR 0.39, 95%CI 0.18-0.82, p < 0.05) in Univariate analysis, but it was insignificant in further multivariate analysis. This is the first large-scale case-control report on the survival risk and prognostic factors of CCPC patients. We found that the prognosis of CCPC patients was significantly worse than that of APC. Surgery might be an effective treatment that may improve its prognosis. Clear cell adenocarcinoma, prostate, acinar carcinoma, survival rate, rare cancer, propensity score matching, case-control study.

534. Outcomes of professional development activities for selected Texas school personnel helping students cope with behavioral and mental health issues.

Sci Rep

2023 Jun 26

Wingenbach G, Koswatta TJ, Engels J

535. Utilizing a tablet-based artificial intelligence system to assess movement disorders in a prospective study.

Sci Rep

2023 Jun 26

Purk M, Fujarski M, Becker M

Spiral drawings on paper are used as routine measures in hospitals to assess Parkinson's Disease motor deficiencies. In the age of emerging mobile health tools and Artificial Intelligence a comprehensive digital setup enables granular biomarker analyses and improved differential diagnoses in movement disorders. This study aims to evaluate on discriminatory features among Parkison's Disease patients, healthy subjects and diverse movement disorders. Overall, 24 Parkinson's Disease patients, 27 healthy controls and 26 patients with similar differential diagnoses were assessed with a novel tablet-based system. It utilizes an integrative assessment by combining a structured symptoms questionnaire-the Parkinson's Disease Non-Motor Scale-and 2-handed spiral drawing captured on a tablet device. Three different classification tasks were evaluated: Parkinson's Disease patients versus healthy control group (Task 1), all Movement disorders versus healthy control group (Task 2) and Parkinson's Disease patients versus diverse other movement disorder patients (Task 3). To systematically study feature importances of digital biomarkers a Machine Learning classifier is cross-validated and interpreted with SHapley Additive exPlanations (SHAP) values. The number of non-motor symptoms differed significantly for Tasks 1 and 2 but not for Task 3. The proposed drawing features partially differed significantly for all three tasks. The diagnostic accuracy was on average 94.0% in Task 1, 89.4% in Task 2, and 72% in Task 3. While the accuracy in Task 3 only using the symptom questionnaire was close to the baseline, it greatly improved when including the tablet-based features from 60 to 72%. The accuracies for all three tasks were significantly improved by integrating the two modalities. These results show that tablet-based drawing features can not only be captured by consumer grade devices, but also capture specific features to Parkinson's Disease that significantly improve the diagnostic accuracy compared to the symptom questionnaire. Therefore, the proposed system provides an objective type of disease characterization of movement disorders, which could be utilized for home-based assessments as well.Clinicaltrials.gov Study-ID: NCT03638479.

536. Discovery of long non-coding RNAs in Aspergillus flavus response to water activity, CO(2) concentration, and temperature changes.

Sci Rep

2023 Jun 26

Davati N, Ghorbani A.

537. Decoupling of scandium and rare earth elements in organic (nano)particle-rich boreal rivers draining the Fennoscandian Shield.

Sci Rep

2023 Jun 26

Klimpel F, Bau M.

538. Dual-functional metalenses for the polarization-controlled generation of focalized vector beams in the telecom infrared.

Sci Rep

2023 Jun 26

Vogliardi A(#), Ruffato G(#), Dal Zilio S

539. Neural complexity through a nonextensive statistical-mechanical approach of human electroencephalograms.

Sci Rep

2023 Jun 26

Abramov DM, Tsallis C, Lima HS.

540. Lectin histochemistry of posterior lingual glands of developing rats.

Sci Rep

2023 Jun 26

Harada K, Miki K, Tanaka S

541. In major joint diseases the human synovium retains its potential to form repair cartilage.

Sci Rep

2023 Jun 26

Hunziker EB, Shintani N, Lippuner K

542. Iron homeostasis in full-term, normal birthweight Gambian neonates over the first week of life.

Sci Rep

2023 Jun 26

Cross JH, Jarjou O, Mohammed NI

543. Frequency-domain interferometry for the determination of time delay between two extreme-ultraviolet wave packets generated by a tandem undulator.

Sci Rep

2023 Jun 25

Hikosaka Y, Kaneyasu T, Wada S

544. Relationships between local variability in parasite communities of the black-spotted croaker (Protonibea diacanthus) (Teleostei: Sciaenidae) and host population structure and seasonality.

Sci Rep

2023 Jun 25

Porter M, Barton DP, Hearnden M

545. A predictive signal model for dynamic cardiac magnetic resonance imaging.

Sci Rep

2023 Jun 25

Curtis AD, Mertens AJ, Cheng HM.

546. Characterization of olfactomedin 4+ cells in prostate and urethral-tube epithelium during murine postnatal development and in adult mice.

Sci Rep

2023 Jun 25

Li H, Chaitankar V, Cui L

547. Efficient deactivation of aerosolized pathogens using a dielectric barrier discharge based cold-plasma detergent in environment device for good indoor air quality.

Sci Rep

2023 Jun 25

Jangra R, Ahlawat K, Dixit A

548. Attitudinal analysis of vaccination effects to lead endemic phases.

Sci Rep

2023 Jun 24

Ku D, Kim G, Peck KR

549. Trend judgment as a perceptual building block of graphicacy and mathematics, across age, education, and culture.

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2023 Jun 24

Ciccione L, Sablé-Meyer M, Boissin E

550. Enyne acetogenins from Porcelia macrocarpa displayed anti-Trypanosoma cruzi activity and cause a reduction in the intracellular calcium level.

Sci Rep

2023 Jun 24

Thevenard F, Brito IA, Costa-Silva TA

Natural products are a promising source of new compounds with a wide spectrum of pharmacological properties, including antiprotozoal activities. Chagas disease, caused by the protozoan parasite Trypanosoma cruzi, is one of several neglected tropical diseases with reduced options for treatment, which presents limitations such as toxicity and ineffectiveness in the chronic stage of the disease. Aiming to investigate the Brazilian flora for the discovery of new anti-T. cruzi compounds, the MeOH extract from Porcelia macrocarpa R.E. Fries (Annonaceae) fruit peels displayed potent activity against trypomastigotes and intracellular amastigotes and was subjected to bioactivity-guided fractionation. Using different chromatographic steps, a fraction composed of a mixture of four new chemically related acetogenins was obtained. The compounds were characterized as (2S*,3R*,4R*)-3-hydroxy-4-methyl-2-(n-octadeca-13',17'-dien-11'-inil)butanolide (1), (2S*,3R*,4R*)-3-hydroxy-4-methyl-2-(n-eicosa-13',19'-dien-11'-inil)butanolide (2), (2S*,3R*,4R*)-3-hydroxy-4-methyl-2-(n-octadec-13'-en-11'-inil)butanolide (3), and (2S*,3R*,4R*)-3-hydroxy-4-methyl-2-(n-eicosa-13'-en-11'-inil)butanolide (4) by NMR analysis and UHPLC/ESI-HRMS data. The mixture of compounds 1-4, displayed an EC50 of 4.9 and 2.5 µg/mL against trypomastigote and amastigote forms of T. cruzi, respectively, similar to the standard drug benznidazole (EC50 of 4.8 and 1.4 µg/mL). Additionally, the mixture of compounds 1-4 displayed no mammalian toxicity for murine fibroblasts (CC50 > 200 µg/mL), resulting in a SI > 40.8 and > 83.3 against trypomastigotes and amastigotes, respectively. Based on these results, the mechanism of action of this bioactive fraction was investigated. After a short-time incubation with the trypomastigotes, no alterations in the cell membrane permeability were observed. However, it was verified a decrease in the intracellular calcium of the parasites, without significant pH variations of the acidocalcisomes. The intracellular damages were followed by an upregulation of the reactive oxygen species and ATP, but no depolarization effects were observed in the mitochondrial membrane potential. These data suggest that the mixture of compounds 1-4 caused an irreversible oxidative stress in the parasites, leading to death. If adequately studied, these acetogenins can open new insights for the discovery of new routes of death in T. cruzi.

551. Wild mockingbirds distinguish among familiar humans.

Sci Rep

2023 Jun 24

Levey DJ, Poulsen JR, Schaeffer AP

552. Tobacco consumption patterns among Iranian adults: a national and sub-national update from the STEPS survey 2021.

Sci Rep

2023 Jun 24

Abbasi-Kangevari M(#), Ghanbari A(#), Fattahi N(#)

Smoking is recognised as a critical public health priority due to its enormous health and economic consequences. Constant monitoring of the effectiveness of tobacco control programs calls for timely population-based data. This study reports the national and sub-national patterns in tobacco consumption among Iranian adults based on the results from the STEPwise approach to chronic disease risk factor surveillance (STEPS) survey 2021. This study was performed through an analysis of the results of the STEPS survey 2021 which had been conducted as a nationally representative cross-sectional study. Participants included Iranian adults aged ≥ 18 years in all provinces of Iran, who were selected via multistage cluster sampling method. Data were analyzed via survey analysis while considering population weights. The total number of participants was 27,874, including 15,395 (55.23%) women and 12,479 (44.77%) men. The all-ages prevalence of current tobacco smoking was 14.01% overall, 4.44% among women, and 25.88% among men. The all-ages prevalence of current cigarette smoking was 9.33% overall, 0.77% among women, and 19.95% among men. The all-ages prevalence of current hookah smoking was 4.5% overall, 3.64% among women, and 5.56% among men. The mean (SD) number of cigarettes smoked per day was 12.41 (10.27) overall, 7.65 (8.09) among women, and 12.64 (10.31) among men. The mean (SD) monthly times of hookah use was 0.42 (7.87) overall, 2.86 (23.46) among women, and 0.3 (6.2) among men. The national all-ages prevalence of second-hand smoking at home was 24.64% overall, 27.38% among women, and 20.26% among men. The national all-ages prevalence of second-hand smoking at work was 19.49% overall, 17.33% among women, and 22.94% among men. The tobacco consumption in Iran remains alarmingly high, indicating the current tobacco control policy implementation level is ineffective and insufficient. This calls for adopting, implementing, and enforcing comprehensive packages of evidence-based tobacco control policies.

553. Acute muscle mass loss was alleviated with HMGB1 neutralizing antibody treatment in severe burned rats.

Sci Rep

2023 Jun 24

Song J, Chowdhury IH(#), Choudhuri S(#)

554. Risk factors for insulin resistance related to polycystic ovarian syndrome in Iranian population.

Sci Rep

2023 Jun 24

Mansour A(#), Mirahmad M(#), Mohajeri-Tehrani MR

Polycystic ovary syndrome (PCOS) has significant metabolic sequelae linked to insulin resistance. This study aimed to compare clinical, metabolic, and hormonal characteristics of PCOS women with and without insulin resistance. The second aim was to compare the clinico-biochemical profiles of the various PCOS phenotypes. In this cross-sectional secondary analysis, we combined the baseline data from two separate randomized controlled trials (RCTs) in women diagnosed with PCOS. PCOS patients were categorized into the four Rotterdam PCOS phenotypes according to the presence of at least two criteria of oligomenorrhea/anovulation (O), hyperandrogenism (H), and polycystic ovary morphology (P): O-H-P, H-P, O-H, and O-P. Participants were categorized into two groups according to the homeostasis model assessment index of insulin resistance (HOMA-IR) levels: < 3.46, and ≥ 3.46. The correlation between the HOMA-IR and biometric, clinical, and biochemical variables was assessed in normal weight (BMI < 25) and overweight/obese (BMI ≥ 25) PCOS women. Then, the association between PCOS phenotypes and insulin resistance was investigated using logistic regression analysis. A total of 125 PCOS patients aged 18-40 years were included in the present study. Based on our results, the HOMA-IR index was positively correlated with diastolic blood pressure, free androgen index, and triglycerides levels; and negatively correlated with sex hormone-binding globulin in overweight/obese PCOS women. In addition, the HOMA-IR index was found to be positively correlated with alanine transaminase and negatively correlated with diastolic blood pressure in normal weight PCOS women. Moreover, individuals with O-H-P phenotype (odds ratio [OR] 2.52, 95% confidence interval [CI] 1.02-6.24) had about two-fold increased risk of insulin resistance. In conclusion, the full-blown PCOS (O-H-P) phenotype has an increased risk of insulin resistance. Accordingly, phenotype division may help physicians to predict adverse metabolic outcomes.

555. Efficient class of estimators for finite population mean using auxiliary attribute in stratified random sampling.

Sci Rep

2023 Jun 24

Singh HP, Gupta A, Tailor R.

556. Identification of hub genes and potential ceRNA networks of diabetic cardiomyopathy.

Sci Rep

2023 Jun 24

Hou J(#), Liang WY(#), Xiong S(#)

557. Recyclable photocatalyst perovskite as a single-electron redox mediator for visible-light-driven photocatalysis gram-scale synthesis of 3,4-dihydropyrimidin-2-(1H)-ones/thiones in air atmosphere.

Sci Rep

2023 Jun 24

Mohamadpour F.

558. A stacking ensemble classifier-based machine learning model for classifying pollution sources on photovoltaic panels.

Sci Rep

2023 Jun 24

Khan PW, Byun YC, Jeong OR.

559. Change in brain asymmetry reflects level of acute alcohol intoxication and impacts on inhibitory control.

Sci Rep

2023 Jun 24

Dubois J, Field RM, Jawhar S

560. Study on the influences of the fractal dimension of the root system and slope degree on the slope stability.

Sci Rep

2023 Jun 24

Hai L, Lv Y, Tan S

561. Comparison of DNA extraction methods for 16S rRNA gene sequencing in the analysis of the human gut microbiome.

Sci Rep

2023 Jun 24

Elie C, Perret M, Hage H

562. Maternal acrylamide exposure changes intestinal epithelium, immunolocalization of leptin and ghrelin and their receptors, and gut barrier in weaned offspring.

Sci Rep

2023 Jun 24

Muszyński S, Hułas-Stasiak M, Dobrowolski P

563. Synthesis, characterization and evaluation of anti-arthritic and anti-inflammatory potential of curcumin loaded chitosan nanoparticles.

Sci Rep

2023 Jun 24

Asif HM, Zafar F, Ahmad K

564. Ab initio calculations on structure and stability of BN/CC isosterism in azulene.

Sci Rep

2023 Jun 24

Abdel-Rahman MA, Soliman KA, Abdel-Azeim S

565. Genetic diversity of Helicobacter pylori type IV secretion system cagI and cagN genes and their association with clinical diseases.

Sci Rep

2023 Jun 24

Azizimoghaddam Y, Kermanpour S, Mirzaei N

566. Early maturation of sound duration processing in the infant's brain.

Sci Rep

2023 Jun 24

Polver S, Háden GP, Bulf H

567. Predicting in-hospital mortality after transcatheter aortic valve replacement using administrative data and machine learning.

Sci Rep

2023 Jun 24

Alhwiti T, Aldrugh S, Megahed FM.

568. Landscape-scale mapping of soil fungal distribution: proposing a new NGS-based approach.

Sci Rep

2023 Jun 24

Janowski D, Leski T.

Soil fungi play an indispensable role in the functioning of terrestrial habitats. Most landscape-scale studies of soil fungal diversity try to identify the fungal taxa present at a study site and define the relationships between their abundance and environmental factors. The specific spatial distribution of these fungi over the site, however, is not addressed. Our study's main objective is to propose a novel approach to landscape-scale mapping of soil fungi distribution using next generation sequencing and geographic information system applications. Furthermore, to test the proposed approach and discuss its performance, we aimed to conduct a case study mapping the spatial distribution of soil fungi on the Wielka Żuława island. The case study was performed on the Wielka Żuława island in northern Poland, where soil samples were collected every 100 m in an even grid. The fungal taxa and their relative abundance in each sample were assessed using the Illumina platform. Using the data obtained for the sampled points, maps of soil fungi spatial distribution were generated using three common interpolators: inverted distance weighted (IDW), B-spline, and ordinary Kriging. The proposed approach succeeded in creating maps of fungal distribution on Wielka Żuława. The most abundant groups of soil fungi were Penicillium on the genus level, Aspergillaceae on the family level, and ectomycorrhizal fungi on the trophic group level. Ordinary Kriging proved to be the most accurate at predicting relative abundance values for the groups of fungi significantly spatially autocorrelated at the sampled scale. For the groups of fungi not displaying spatial autocorrelation at the sampled scale, IDW provided the most accurate predictions of their relative abundance. Although less accurate at predicting exact relative abundance values, B-spline performed best in delineating the spatial patterns of soil fungi distribution. The proposed approach to landscape-scale mapping of soil fungi distribution could provide new insights into the ecology of soil fungi and terrestrial ecosystems in general. Producing maps of predicted fungal distribution in landscape-scale soil fungi diversity studies would also facilitate the reusability and replicability of the results. Outside the area of research, mapping the distribution of soil fungi could prove helpful in areas such as agriculture and forestry, nature conservation, and urban planning.

569. Uniquely low stable iron isotopic signatures in deep marine sediments caused by Rayleigh distillation.

Sci Rep

2023 Jun 24

Köster M, Staubwasser M, Meixner A

570. Hyperphagia of female UCP1-deficient mice blunts anti-obesity effects of FGF21.

Sci Rep

2023 Jun 24

Klein Hazebroek M, Laterveer R, Kutschke M

571. Causes of death among patients with cutaneous melanoma: a US population-based study.

Sci Rep

2023 Jun 24

Sadeq MA(#), Ashry MH(#), Ghorab RMF

572. Intraspecific competition and individual behaviour but not urbanization affect the dietary patterns of a generalist avian predator.

Sci Rep

2023 Jun 24

Romero-Vidal P, Luna Á, Fernández-Gómez L

Urbanization has reshaped ecosystems and changed natural processes, driving an intense transformation of biomes, biotic community composition and diversity. Despite the growing interest in studying urban ecology over the last decades, the consequences of these changes on species occupying these ecosystems are not yet fully understood. Trophic generalism and tolerance to human disturbance have been proposed as two key traits in the colonization of urban environments. However, most studies focused on species' average traits, paying less attention to the potential role of inter-individual variability. Here, we examined diet specialization in urban and rural breeding pairs, as well as its relationship with individual behaviour and intraspecific competition, using the burrowing owl as a study model. Our results show that both urban and rural breeding pairs behaved as trophic specialists. The diet of burrowing owl breeding pairs followed a gradient from coleopteran- to micromammal-dominated, which is related to individual behaviour (bolder individuals consuming more coleopterans than shyer ones). Besides, pairs distant from others showed a more diverse diet than those experiencing higher levels of intraspecific competition. Models fitted separately for each habitat showed that the proportion of micromammals in the diet of urban breeding pairs was related to their behavior, while the diet of rural pairs was not affected by individual behavior but by intraspecific competition. However, despite the strong selection of tame and more explorative individuals in urban environments and the higher density they reach in this habitat type, they did not differ in their degree of diet specialization from rural conspecifics. Although it would be necessary to evaluate prey availability on a small scale, our results suggest that burrowing owl breeding pairs behave as specialists, despite the generalist character of the species, and that this specialization is not affected by the occupation of urban environments but to individual behaviour and intraspecific competition.

573. Automatic speaker diarization for natural conversation analysis in autism clinical trials.

Sci Rep

2023 Jun 24

O'Sullivan J, Bogaarts G, Schoenenberger P

574. Cascade of diabetes care in Bangladesh, Bhutan and Nepal: identifying gaps in the screening, diagnosis, treatment and control continuum.

Sci Rep

2023 Jun 24

Islam MT, Bruce M, Alam K.

575. High-efficiency upconversion process in cobalt and neodymium doped graphene QDs for biomedical applications.

Sci Rep

2023 Jun 24

Zarghami A, Dolatyari M, Mirtagioglu H

576. Transcriptomic analysis reveals distinct adaptive molecular mechanism in the hippocampal CA3 from rats susceptible or not-susceptible to hyperthermia-induced seizures.

Sci Rep

2023 Jun 24

Bando SY, Bertonha FB, Menezes PHN

577. Multiobjective optimization to assess dengue control costs using a climate-dependent epidemiological model.

Sci Rep

2023 Jun 24

de Vasconcelos ASV, de Lima JS(#), Cardoso RTN(#).

578. The sequence of the repetitive motif influences the frequency of multistep mutations in Short Tandem Repeats.

Sci Rep

2023 Jun 24

Antão-Sousa S, Pinto N, Rende P

Microsatellites, or Short Tandem Repeats (STRs), are subject to frequent length mutations that involve the loss or gain of an integer number of repeats. This work aimed to investigate the correlation between STRs' specific repetitive motif composition and mutational dynamics, specifically the occurrence of single- or multistep mutations. Allelic transmission data, comprising 323,818 allele transfers and 1,297 mutations, were gathered for 35 Y-chromosomal STRs with simple structure. Six structure groups were established: ATT, CTT, TCTA/GATA, GAAA/CTTT, CTTTT, and AGAGAT, according to the repetitive motif present in the DNA leading strand of the markers. Results show that the occurrence of multistep mutations varies significantly among groups of markers defined by the repetitive motif. The group of markers with the highest frequency of multistep mutations was the one with repetitive motif CTTTT (25% of the detected mutations) and the lowest frequency corresponding to the group with repetitive motifs TCTA/GATA (0.93%). Statistically significant differences (α = 0.05) were found between groups with repetitive motifs with different lengths, as is the case of TCTA/GATA and ATT (p = 0.0168), CTT (p < 0.0001) and CTTTT (p < 0.0001), as well as between GAAA/CTTT and CTTTT (p = 0.0102). The same occurred between the two tetrameric groups GAAA/CTTT and TCTA/GATA (p < 0.0001) - the first showing 5.7 times more multistep mutations than the second. When considering the number of repeats of the mutated paternal alleles, statistically significant differences were found for alleles with 10 or 12 repeats, between GATA and ATT structure groups. These results, which demonstrate the heterogeneity of mutational dynamics across repeat motifs, have implications in the fields of population genetics, epidemiology, or phylogeography, and whenever STR mutation models are used in evolutionary studies in general.

579. Low length-for-age Z-score within 1 month after birth predicts hyperdynamic circulation at the age of 21 years in rural Malawi.

Sci Rep

2023 Jun 24

Penninkangas RM, Choudhary MK, Mangani C

580. Nanosilica modulates C:N:P stoichiometry attenuating phosphorus toxicity more than deficiency in Megathyrsus maximus cultivated in an Oxisol and Entisol.

Sci Rep

2023 Jun 24

de Faria Melo CC, Silva Amaral D, de Mello Prado R

581. Optimal surgical procedure for treating early-stage adenoid cystic carcinoma of the breast.

Sci Rep

2023 Jun 23

Huang T, Fang Q, Niu L

582. Echocardiographic assessment of brain sparing in small-for-gestational age infants and association with neonatal outcomes.

Sci Rep

2023 Jun 23

Shin JA, Lee JY, Yum SK.

583. A collaborative and near-comprehensive North Pacific humpback whale photo-ID dataset.

Sci Rep

2023 Jun 23

Cheeseman T, Southerland K, Acebes JM

584. GATS tag system is compatible with biotin labelling methods for protein analysis.

Sci Rep

2023 Jun 23

Yamada K, Soga F, Tokunaga S

585. Electrostatic complementarity at the interface drives transient protein-protein interactions.

Sci Rep

2023 Jun 23

Grassmann G, Di Rienzo L, Gosti G

Understanding the mechanisms driving bio-molecules binding and determining the resulting complexes' stability is fundamental for the prediction of binding regions, which is the starting point for drug-ability and design. Characteristics like the preferentially hydrophobic composition of the binding interfaces, the role of van der Waals interactions, and the consequent shape complementarity between the interacting molecular surfaces are well established. However, no consensus has yet been reached on the role of electrostatic. Here, we perform extensive analyses on a large dataset of protein complexes for which both experimental binding affinity and pH data were available. Probing the amino acid composition, the disposition of the charges, and the electrostatic potential they generated on the protein molecular surfaces, we found that (i) although different classes of dimers do not present marked differences in the amino acid composition and charges disposition in the binding region, (ii) homodimers with identical binding region show higher electrostatic compatibility with respect to both homodimers with non-identical binding region and heterodimers. Interestingly, (iii) shape and electrostatic complementarity, for patches defined on short-range interactions, behave oppositely when one stratifies the complexes by their binding affinity: complexes with higher binding affinity present high values of shape complementarity (the role of the Lennard-Jones potential predominates) while electrostatic tends to be randomly distributed. Conversely, complexes with low values of binding affinity exploit Coulombic complementarity to acquire specificity, suggesting that electrostatic complementarity may play a greater role in transient (or less stable) complexes. In light of these results, (iv) we provide a novel, fast, and efficient method, based on the 2D Zernike polynomial formalism, to measure electrostatic complementarity without the need of knowing the complex structure. Expanding the electrostatic potential on a basis of 2D orthogonal polynomials, we can discriminate between transient and permanent protein complexes with an AUC of the ROC of [Formula: see text] 0.8. Ultimately, our work helps shedding light on the non-trivial relationship between the hydrophobic and electrostatic contributions in the binding interfaces, thus favoring the development of new predictive methods for binding affinity characterization.

586. Synthesis of unsymmetrically and symmetrically functionalized disiloxanes via subsequent hydrosilylation of C≡C bonds.

Sci Rep

2023 Jun 23

Szyling J, Walkowiak J, Czapik A

587. The trilemma among CO(2) emissions, energy use, and economic growth in Russia.

Sci Rep

2023 Jun 23

Magazzino C, Mele M, Drago C

588. Facile synthesis of spongy NiCo(2)O(4) powders for lithium-ion storage.

Sci Rep

2023 Jun 23

Mahboubi H, Masoudpanah SM, Alamolhoda S

589. A comparative study of femtosecond pulsed laser ablation of meloxicam in distilled water and in air.

Sci Rep

2023 Jun 23

Nagy E, Kopniczky J, Smausz T

590. Environmental risk factors of systemic lupus erythematosus: a case-control study.

Sci Rep

2023 Jun 23

Refai RH, Hussein MF, Abdou MH

591. Spatial distribution of elements during osteoarthritis disease progression using synchrotron X-ray fluorescence microscopy.

Sci Rep

2023 Jun 23

Fan X, Lee KM, Jones MWM

592. Tau protein binds to the P53 E3 ubiquitin ligase MDM2.

Sci Rep

2023 Jun 23

Sola M, Rendon-Angel A, Rojo Martinez V

593. A newly identified small tRNA fragment reveals the regulation of different wool types and oxidative stress in lambs.

Sci Rep

2023 Jun 23

Wang J, Hua G, Yang X

594. Preparation of novel Zn-Al layered double hydroxide composite as adsorbent for removal of organophosphorus insecticides from water.

Sci Rep

2023 Jun 23

Ghanbari N, Ghafuri H.

595. Absorbance biosensors-based hybrid [Formula: see text] nanosheets for Escherichia coli detection.

Sci Rep

2023 Jun 23

Nguyen SH, Vu PKT, Tran MT.

596. Phylogeny, ancestral ranges and reclassification of sand dollars.

Sci Rep

2023 Jun 23

Lee H(#), Lee KS(#), Hsu CH

597. Cathodoluminescence as a tracing technique for quartz precipitation in low velocity shear experiments.

Sci Rep

2023 Jun 23

Hamers MF, Niemeijer AR, Drury MR.

598. Identification of protein phosphatase 4 catalytic subunit as a Wnt promoting factor in pan-cancer and Xenopus early embryogenesis.

Sci Rep

2023 Jun 23

Wang Y, Han W, Yun S

599. Longitudinal investigation of changes in resting-state co-activation patterns and their predictive ability in the zQ175 DN mouse model of Huntington's disease.

Sci Rep

2023 Jun 23

Adhikari MH(#), Vasilkovska T(#), Cachope R

600. Shorter telomere length predicts poor antidepressant response and poorer cardiometabolic indices in major depression.

Sci Rep

2023 Jun 23

Rampersaud R, Wu GWY, Reus VI

601. An innovative probabilistic hesitant fuzzy set MCDM perspective for selecting flexible packaging bags after the prohibition on single-use plastics.

Sci Rep

2023 Jun 23

Jeon J, Krishnan S, Manirathinam T

602. Automated, non-invasive Varroa mite detection by vibrational measurements of gait combined with machine learning.

Sci Rep

2023 Jun 23

Hall H, Bencsik M, Newton M.

603. Development of a one-shot dual aptamer-based fluorescence nanosensor for rapid, sensitive, and label-free detection of periostin.

Sci Rep

2023 Jun 23

Park J, Ban C.

604. Distinctions between the Koizumi and Zea Longa methods for middle cerebral artery occlusion (MCAO) model: a systematic review and meta-analysis of rodent data.

Sci Rep

2023 Jun 23

Li Y, Tan L, Yang C

605. Using macular velocity measurements to relate parameters of bone conduction to vestibular compound action potential responses.

Sci Rep

2023 Jun 23

Pastras CJ, Curthoys IS, Rabbitt RD

606. Development and validation of a nomogram to predict long-term cancer-specific survival for patients with osteosarcoma.

Sci Rep

2023 Jun 23

Yu Y, Wang S, Liu J

The present work aimed to establish a new model to accurately estimate overall survival (OS) as well as cancer-specific survival (CSS) of osteosarcoma. Osteosarcoma cases were collected from the Surveillance, Epidemiology, and End Results (SEER) database between 2004 and 2017 and randomized as training or validation sets. Then, the OS- and CSS-related variables were discovered through multivariate Cox regression analysis to develop new nomograms to predict the 1-, 3- and 5-year OS and CSS. Besides, consistency index (C-index), decision curve analysis (DCA), along with calibration curve were adopted for assessing the predicting ability of our constructed nomograms after calibrating for 1-, 3- and 5-year OS and CSS. Altogether, 1727 osteosarcoma cases were enrolled in the present study and randomly divided as training (n = 1149, 70%) or validation (n = 576, 30%) set. As shown by univariate as well as multivariate Cox regression analyses, age, grade, T stage, M stage, surgery, chemotherapy, and histological type were identified to be the adverse factors to independently predict OS and CSS among the osteosarcoma cases. Besides, based on results of multivariate Cox regression analysis, we constructed the OS and CSS prediction nomograms. The C-index in training set was 0.806 (95% CI 0.769-0.836) for OS nomogram and 0.807 (95% CI 0.769-0.836) for CSS nomogram. In the meantime, C-index value in validation set was 0.818 (95% CI 0.789-0.847) for OS nomogram, while 0.804 (95% CI 0.773-0.835) for CSS nomogram. Besides, those calibration curves regarding the 3- and 5-year CSS of our constructed nomogram were highly consistent between the predicted values and the measurements in the training set as well as the external validation set. Our constructed nomogram outperformed the TNM stage in prediction. Our constructed nomogram is facile, creditable, and feasible; it efficiently predicts OS and CSS for osteosarcoma cases and can assist clinicians in assessing the prognosis for individuals and making decisions.

607. Association between obstructive sleep apnea symptoms and gout in US population, a cross-sectional study.

Sci Rep

2023 Jun 23

Gu X(#), Tang D(#), Xuan Y(#)

608. Antibacterial nanocomposite of chitosan/silver nanocrystals/graphene oxide (ChAgG) development for its potential use in bioactive wound dressings.

Sci Rep

2023 Jun 23

Estévez-Martínez Y, Vázquez Mora R, Méndez Ramírez YI

609. Impact of community-based interventions on out-of-hospital cardiac arrest outcomes: a systematic review and meta-analysis.

Sci Rep

2023 Jun 23

Simmons KM, McIsaac SM, Ohle R.

Survival following out-of-hospital cardiac arrest (OHCA) remains low, typically less than 10%. Bystander cardiopulmonary resuscitation (CPR) and bystander-AED use have been shown to improve survival by up to fourfold in individual studies. Numerous community-based interventions have been implemented worldwide in an effort to enhance rates of bystander-CPR, bystander-AED use, and improve OHCA survival. This systematic review and meta-analysis aims to evaluate the effect of such interventions on OHCA outcomes. Medline and Embase were systematically searched from inception through July 2021 for studies describing the implementation and effect of one or more community-based interventions targeting OHCA outcomes. Two reviewers screened articles, extracted data, and evaluated study quality using the Newcastle-Ottawa Scale. For each outcome, data were pooled using random-effects meta-analysis. Of the 2481 studies identified, 16 met inclusion criteria. All included studies were observational. They reported a total of 1,081,040 OHCAs across 11 countries. The most common interventions included community-based CPR training (n = 12), community-based AED training (n = 9), and dispatcher-assisted CPR (n = 8). Health system interventions (hospital or paramedical services) were also described in 11 of the included studies. Evidence certainty among all outcomes was low or very low according to GRADE criteria. On meta-analysis, community-based interventions with and without health system interventions were consistently associated with improved OCHA outcomes: rates of bystander-CPR, bystander-AED use, survival, and survival with a favorable neurological outcome. Bystander CPR-14 studies showed a significant increase in post-intervention bystander-CPR rates (n = 285 752; OR 2.26 [1.74, 2.94]; I2 = 99%, and bystander AED use (n = 37 882; OR 2.08 [1.44, 3.01]; I2 = 54%) and durvival-10 studies, pooling survival to hospital discharge and survival to 30 days (n = 79 206; OR 1.59 [1.20, 2.10]; I2 = 95%. The results provide foundational support for the efficacy of community-based interventions in enhancing OHCA outcomes. These findings inform our recommendation that communities, regions, and countries should implement community-based interventions in their pre-hospital strategy for OHCA. Further research is needed to identify which specific intervention types are most effective.

610. Conduit design with expanding diameter for enhanced flow.

Sci Rep

2023 Jun 23

Hashemi J, Peeples H, Kuykendall R

611. Deep learning supported machine vision system to precisely automate the wild blueberry harvester header.

Sci Rep

2023 Jun 23

Haydar Z, Esau TJ, Farooque AA

612. Quantification of tramadol and serotonin by cobalt nickel tungstate in real biological samples to evaluate the effect of analgesic drugs on neurotransmitters.

Sci Rep

2023 Jun 23

Zafar K, Wasim M, Fatima B

613. Resistance training rejuvenates aging skin by reducing circulating inflammatory factors and enhancing dermal extracellular matrices.

Sci Rep

2023 Jun 23

Nishikori S, Yasuda J, Murata K

614. Thermal management analyses of induction motor through the combination of air-cooling and an integrated water-cooling system.

Sci Rep

2023 Jun 22

Madhavan S, Devdatta P B R, Konda YR

615. Soil-transmitted helminthiasis (STH) endemicity and performance of preventive chemotherapy intervention programme in Nigeria (in year 2021).

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2023 Jun 22

Oyeyemi OT, Okunlola OA.

616. The histone H2B Arg95 residue efficiently recruits the transcription factor Spt16 to mediate Ste5 expression of the pheromone response pathway.

Sci Rep

2023 Jun 22

Sulaiman AA, Ali R, Ramotar D.

617. Impact of systemic dexamethasone dosage on docetaxel-induced oral mucositis in patients with breast cancer.

Sci Rep

2023 Jun 22

Saito Y, Takekuma Y, Takeshita T

618. Moral reframing of messages about mask-wearing during the COVID-19 pandemic.

Sci Rep

2023 Jun 22

Kaplan JT, Vaccaro A, Henning M

619. [1,2,4]triazolo[3,4-b][1,3,4]thiadiazole derivatives as new therapeutic candidates against urease positive microorganisms: design, synthesis, pharmacological evaluations, and in silico studies.

Sci Rep

2023 Jun 22

Khalili Ghomi M, Noori M, Nazari Montazer M

620. Micronutrient intake status and associated factors in children aged 6-23 months in sub-Saharan Africa.

Sci Rep

2023 Jun 22

Engidaw MT, Gebremariam AD, Tiruneh SA

Micronutrient deficiency has serious consequences across all ages worldwide, particularly in sub-Saharan Africa. Poor micronutrient (MN) consumption among children remains a major public health concern in many countries. Low literacy, poor diets, a lack of access to healthcare, and insufficient agricultural productivity made proper micronutrient consumption difficult, despite numerous interventions. Thus, this research aimed to determine the adequate intake of MNs among 6-23 months of age children in sub-Saharan Africa. Initially, a two-stage stratified sampling technique was applied for the selected recent demographic and health survey data. The data source was the (2015-2020) standard demographic and health surveys (DHS) among 20 Sub-Saharan African countries. Micronutrient intake status (the outcome variable) was determined using either food rich in Vitamin A or iron consumed within the previous 24 hr or multiple micronutrient powder or iron supplementation within the previous 07 days or vitamin A supplementation or deworming within 06 months. A generalized linear mixed model based on Modified Poisson regression and robust error variance was used to identify factors associated with children's adequate micronutrient intake. An adjusted Prevalence Ratio (aPR) with a 95% confidence interval was used to identify factors, strength and direction of the association. The total samples of 65,187 children aged 6-23 months were included. Of all, 73.99% (95% CI: 73.65, 74.32) of children had adequate intake of micronutrients. Maternal education (primary (aPR = 1.04, 95% CI: 1.02, 1.06) and secondary (aPR = 1.07, 95% CI: 1.04, 1.09)), father's education (primary (aPR = 1.03, 95% CI: 1.01, 1.05) and secondary (aPR = 1.04, 95% CI: 1.02, 1.06)), occupational status of the mother (aPR = 1.04, 95% CI: 1.02, 1.06), pregnancy interval (aPR = 0.97, 95% CI: 0.95, 0.99), exclusive breastfeeding status (aPR = 0.83, 95% CI: 0.82, 0.85), birthweight (average (aPR = 1.03, 95% CI: 1.01, 1.05) and larger than average (aPR = 1.04, 95% CI: 1.02, 1.06)), multiple/twin at birth (aPR = 0.94, 95% CI: 0.91, 0.98), child age (aPR = 1.22, 95% CI: 1.19, 1.25), number of children in home (aPR = 1.02, 95% CI: 1.01, 1.03), ANC utilization (aPR = 1.20, 95% CI: 1.15, 1.27), place of birth (AOR = 0.93, 95% CI: 0.91, 0.95), rich households (aPR = 1.03, 95% CI: 1.01, 1.05), and countries from Central (aPR = 1.07, 95% CI: 1.04, 1.09), South Africa (aPR = 1.07, 95% CI: 1.03, 1.11), and West African (aPR = 0.95, 95% CI: 0.92, 0.99) were associated with level of micronutrients intake status. The prevalence of adequate intake of MN was considerable. Variables at the child, family and community levels were associated with adequate intake of micronutrients. Consequently, stakeholders' involvement is required in healthcare and community settings.

621. The interplay between cognition, functional and dual-task gait in persons with a vestibular disorder versus healthy controls.

Sci Rep

2023 Jun 22

Pavlou M, Costafreda SG, Galsworthy W

622. A coiled-coil-based design strategy for the thermostabilization of G-protein-coupled receptors.

Sci Rep

2023 Jun 22

Amer M, Leka O, Jasko P

623. In-situ preparation of sulfonated carbonaceous copper oxide-zirconia nanocomposite as a novel and recyclable solid acid catalyst for reduction of 4-nitrophenol.

Sci Rep

2023 Jun 22

Farrag M.

The missing-linker defects of UiO-66 were exploited to covalently anchor Cu nanoclusters (Cu/UiO-66). The molecular interactions between the metals and oxides as copper-zirconia interfaces in Cu/UiO-66 are essential for heterogeneous catalysis, leading to remarkable synergistic impacts on activity and selectivity. Homogeneously distributed carbonaceous mixed metal oxides (CuO/ZrO2@C) nanocomposite was prepared via carbonization of the Cu/UiO-66 at 600 °C for 3 h in air. To enhance the acidity properties of the CuO/ZrO2@C nanocomposite, a small amount of sulfuric acid was added and heated at 150 °C under an N2 atmosphere (CuO/ZrO2-SO3H@C). The synthesised Cu/UiO-66 and CuO/ZrO2-SO3H@C catalysts were used as novel catalysts in the reduction of 4-nitrophenol (4-NP) to 4-aminophenol (4-AP). The Cu/UiO-66 and CuO/ZrO2-SO3H@C catalysts displayed complete conversion of the 4-NP solution during (4 and 2 min) stirring at room temperature, respectively. These two catalysts exhibited a high reduction rate of 8.61 × 10-3 s-1, and 18.3 × 10-3 s-1, respectively. The X-ray photoelectron spectroscopic (XPS) analysis showed the charge of copper atoms in the Cu/UiO-66 catalyst was Cu0/CuII and in the CuO/ZrO2-SO3H@C catalyst was CuI/CuII with nearly the same ratio (65/35). The particle size and the elemental composition of the CuO/ZrO2-SO3H@C catalyst were analysed by using high resolution transmission electron microscopy (HR-TEM), and energy-dispersive X-ray spectroscopy (EDS), and elemental mapping, respectively. The key point beyond the high catalytic activity and selectivity of the CuO/ZrO2-SO3H@C catalyst is both the carbon-metal oxides heterojunction structure that leads to good dispersion of the CuO and ZrO2 over the carbon sheets, and the high acidity properties that come from the combination between the Brønsted acid sites from sulfuric acid and Lewis acid sites from the UiO-66. The catalysts exhibited good recyclability efficiency without significant loss in activity, indicating their good potential for industrial applications.

624. Proteomic-based identification of APCS as candidate protein for diagnosis of patients exhibiting anti-tubercular drug induced liver injury.

Sci Rep

2023 Jun 22

Kaur B, Dixit R, Bakshi S

625. Prediction of prostate cancer biochemical recurrence by using discretization supports the critical contribution of the extra-cellular matrix genes.

Sci Rep

2023 Jun 22

Marin L, Casado F.

626. Biosynthesis of cellulose from Ulva lactuca, manufacture of nanocellulose and its application as antimicrobial polymer.

Sci Rep

2023 Jun 22

El-Sheekh MM, Yousuf WE, Kenawy ER

627. Prevalence and influencing factors of hyperuricemia in middle-aged and older adults in the Yao minority area of China: a cross-sectional study.

Sci Rep

2023 Jun 22

Lyu X, Du Y, Liu G

628. Deep-learning approach to detect childhood glaucoma based on periocular photograph.

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2023 Jun 22

Kitaguchi Y, Hayakawa R, Kawashima R

629. A statistical modeling approach based on the small-scale field trial and meteorological data for preliminary prediction of the impact of low temperature on Eucalyptus globulus trees.

Sci Rep

2023 Jun 22

Chubachi T(#), Oguchi T(#), Morita K

630. Paying attention to the outcome of others' actions has dissociated effects on observer's peripersonal space representation and exploitation.

Sci Rep

2023 Jun 22

Gigliotti MF, Bartolo A, Coello Y.

631. Effect of synbiotics on growth performance, gut health, and immunity status in pre-ruminant buffalo calves.

Sci Rep

2023 Jun 22

Sharma AN(#), Chaudhary P(#), Kumar S

Synbiotics are employed as feed additives in animal production as an alternate to antibiotics for sustaining the gut microbiota and providing protection against infections. Dairy calves require a healthy diet and management to ensure a better future for the herd of dairy animals. Therefore, the present study was carried out to investigate the effect of synbiotics formulation on growth performance, nutrient digestibility, fecal bacterial count, metabolites, immunoglobulins, blood parameters, antioxidant enzymes and immune response of pre-ruminant Murrah buffalo calves. Twenty-four apparently healthy calves (5 days old) were allotted into four groups of six calves each. Group I (control) calves were fed a basal diet of milk, calf starter and berseem with no supplements. Group II (SYN1) calves were fed with 3 g fructooligosaccharide (FOS) + Lactobacillus plantarum CRD-7 (150 ml). Group III (SYN2) calves were fed with 6 g FOS + L. plantarum CRD-7 (100 ml), whereas calves in group IV (SYN3) received 9 g FOS + L. plantarum CRD-7 (50 ml). The results showed that SYN2 had the highest (P < 0.05) crude protein digestibility and average daily gain compared to the control. Fecal counts of Lactobacilli and Bifidobacterium were also increased (P < 0.05) in supplemented groups as compared to control. Fecal ammonia, diarrhea incidence and fecal scores were reduced in treated groups while lactate, volatile fatty acids and antioxidant enzymes were improved compared to the control. Synbiotic supplementation also improved both cell-mediated and humoral immune responses in buffalo calves. These findings indicated that synbiotics formulation of 6 g FOS + L. plantarum CRD-7 in dairy calves improved digestibility, antioxidant enzymes, and immune status, as well as modulated the fecal microbiota and decreased diarrhea incidence. Therefore, synbiotics formulation can be recommended for commercial use in order to achieve sustainable animal production.

632. Chronicity of high and low level mupirocin resistance in Staphylococcus aureus from 30 Indian hospitals.

Sci Rep

2023 Jun 22

Prakash R, Garg A, Arya R

Mupirocin is one of the most effective topically used antibiotic for the treatment of dermatitis, nasal carriage, decolonization of methicillin susceptible Staphylococcus aureus and eradication of methicillin resistant Staphylococcus aureus. Extensive use of this antibiotic has resulted in mupirocin resistance in Staphylococcus aureus which is a matter of concern. This study was conducted to evaluate the high and low level of mupirocin resistance in Staphylococcus aureus collected from various Indian hospitals. A total of 600 samples, of which 436 were pus specimens and 164 wound site swabs were collected from 30 Indian hospitals. Disc diffusion and agar dilution methods were used to test mupirocin susceptibility in methicillin resistant Staphylococcus aureus. Out of 600 Staphylococcus aureus isolates, 176 isolates (29.33%) were found to be methicillin resistant Staphylococcus aureus (MRSA). Out of 176 non-duplicate MRSA strains, 138 isolates were found to be mupirocin sensitive, 21 isolates had high level resistance whereas 17 isolates had low level resistance to mupirocin, which contributed 78.41%, 11.93% and 9.66% respectively. Multidrug resistant susceptibility was tested for all the MRSA with Cefuroxime, Cotrimoxazole and Vancomycin antibiotics. All the high and low level resistant strain were subjected to genome screening for mupA ileS gene respectively. mupA gene was found positive in all the high level resistant strain and out of 17 low level resistant strain, 16 strain were found point mutation in V588F of ileS gene. Overall, high rate of mupirocin resistance was found in the studied samples which might be a result of indiscriminate use of mupirocin in the population of studied region. This data emphasizes the urgent need for formulation of a well-defined and regulated guidelines for mupirocin use. Moreover, continuous surveillance is needed for the use of mupirocin and routine test should be performed to detect MRSA in patients and health care personnel to prevent MRSA infections.

633. Direct input of monitoring data into a mechanistic ecological model as a way to identify the phytoplankton growth-rate response to temperature variations.

Sci Rep

2023 Jun 22

Medvinsky AB, Nurieva NI, Adamovich BV

634. An automatic and personalized recommendation modelling in activity eCoaching with deep learning and ontology.

Sci Rep

2023 Jun 22

Chatterjee A, Prinz A, Riegler MA

Electronic coaching (eCoach) facilitates goal-focused development for individuals to optimize certain human behavior. However, the automatic generation of personalized recommendations in eCoaching remains a challenging task. This research paper introduces a novel approach that combines deep learning and semantic ontologies to generate hybrid and personalized recommendations by considering "Physical Activity" as a case study. To achieve this, we employ three methods: time-series forecasting, time-series physical activity level classification, and statistical metrics for data processing. Additionally, we utilize a naïve-based probabilistic interval prediction technique with the residual standard deviation used to make point predictions meaningful in the recommendation presentation. The processed results are integrated into activity datasets using an ontology called OntoeCoach, which facilitates semantic representation and reasoning. To generate personalized recommendations in an understandable format, we implement the SPARQL Protocol and RDF Query Language (SPARQL). We evaluate the performance of standard time-series forecasting algorithms [such as 1D Convolutional Neural Network Model (CNN1D), autoregression, Long Short-Term Memory (LSTM), and Gated Recurrent Units (GRU)] and classifiers [including Multilayer Perceptron (MLP), Rocket, MiniRocket, and MiniRocketVoting] using state-of-the-art metrics. We conduct evaluations on both public datasets (e.g., PMData) and private datasets (e.g., MOX2-5 activity). Our CNN1D model achieves the highest prediction accuracy of 97[Formula: see text], while the MLP model outperforms other classifiers with an accuracy of 74[Formula: see text]. Furthermore, we evaluate the performance of our proposed OntoeCoach ontology model by assessing reasoning and query execution time metrics. The results demonstrate that our approach effectively plans and generates recommendations on both datasets. The rule set of OntoeCoach can also be generalized to enhance interpretability.

635. Optimizing extinguishing angle of 6MF-30 pneumatic extinguisher for wildland fire-fighting based on CFD and experiments.

Sci Rep

2023 Jun 22

Chen F, Miao B, Wang Q.

636. A randomized controlled trial for evaluating an occupational therapy self management intervention in adults with type 2 diabetes.

Sci Rep

2023 Jun 22

Binesh M, Shafaroodi N, Mirmohammadkhani M

637. Plasma-discharge-integrated slot structure for microwave power limiter.

Sci Rep

2023 Jun 22

Woo JM, Ju MN, Lee JB.

638. Improving recycling sorting behaviour with human eye nudges.

Sci Rep

2023 Jun 22

Lotti L, Barile L, Manfredi G.

639. Synthesis and characterization of nanocatalyst Cu(2+)/mesoporous carbon for amidation reactions of alcohols.

Sci Rep

2023 Jun 22

Ghafuri H, Hanifehnejad P, Rashidizadeh A

640. Physics-informed neural ODE (PINODE): embedding physics into models using collocation points.

Sci Rep

2023 Jun 22

Sholokhov A, Liu Y, Mansour H

641. Intracerebral gadolinium deposition following blood-brain barrier disturbance in two different mouse models.

Sci Rep

2023 Jun 22

Kromrey ML, Oswald S, Becher D

642. Characterization of a rhabdomyosarcoma reveals a critical role for SMG7 in cancer cell viability and tumor growth.

Sci Rep

2023 Jun 22

Steiner AJ, Zheng Y, Tang Y.

643. Numerical simulation of deposition of drifts and salt from multiple super-large seawater cooling towers.

Sci Rep

2023 Jun 22

Liang Z, Li L, Yang J

644. 3D fractures analysis and conservation assessment of wrought iron javelin through advanced non-invasive techniques.

Sci Rep

2023 Jun 22

Bernabale M, Cognigni F, Mancini C

645. The effect of familiarity on behavioral oscillations in face perception.

Sci Rep

2023 Jun 22

Liu X, Melcher D.

646. Miniaturized V-band circularly polarized leaky-wave antenna with continuous radiation coverage using modified waveguide and metasurface CSRRs.

Sci Rep

2023 Jun 22

Torabi Y, Oraizi H, Araghi A

647. A convolutional recurrent neural network with attention for response prediction to repetitive transcranial magnetic stimulation in major depressive disorder.

Sci Rep

2023 Jun 22

Shahabi MS, Shalbaf A, Rostami R

648. Transmission of haemotropic mycoplasma in the absence of arthropod vectors within a closed population of dogs on ectoparasiticides.

Sci Rep

2023 Jun 22

Huggins LG, Baydoun Z, Mab R

649. A method for selecting reference beam model of VMAT plans with three 6MV beam-matched linear accelerators during radiation oncology.

Sci Rep

2023 Jun 22

Li Y(#), Wu W, Yuan W

650. Effects of corn grain processing and protein source on calf performance, rumen fermentation, and blood metabolites.

Sci Rep

2023 Jun 22

Jafarpour M, Alikhani M, Riasi A

The objective of this study was to investigate the effects of the interaction between corn grain processing and protein source on feed intake, growth performance, rumen fermentation, and blood metabolites of dairy calves. Seventy-two 3-day-old Holstein calves with an initial weight of 39.1 ± 3.24 kg were randomly assigned (n = 12 calves (6 male and 6 female) per treatment) to a 2 × 3 factorial arrangement of treatments with the factors of physical form of the corn grain [coarsely ground (CG) and steam-flaked (SF)] and protein type [canola meal (CAN), canola meal + soybean meal (CASY), and soybean meal (SOY)] were assigned. The study showed a significant correlation between corn grain processing method and protein source on calf performance, including starter feed intake, total dry matter intake (DMI), body weight, average daily gain (ADG), and feed efficiency (FE). The CG-CAN and SF-SOY treatments resulted in the highest feed intake and DMI in the post-weaning and total period, respectively. Interestingly, corn processing did not affect feed intake, ADG, and FE, but the highest ADG was observed at SF-SOY and CG-CAN. In addition, the interaction between corn processing method and protein source improved FE in calves fed CG-CAN and SF-SOY during the preweaning period and throughout the period. Although skeletal growth parameters were unchanged, calves fed SOY and CASY had greater body length and withers height than calves fed CAN during the preweaning period. Rumen fermentation parameters were also not affected by the treatments, except that calves fed CAN had a higher molar proportion of acetate than calves fed SOY and CASY. Corn grain processing and protein source did not affect glucose, blood urea nitrogen (BUN), or β-hydroxybutyrate (BHB) concentrations, except for the highest blood glucose level observed in the CAN treatment and the highest BUN level observed in the preweaned calves fed SOY. However, a two-way interaction was observed for BHB concentration, suggesting that ground corn grain resulted in higher BHB concentration during the preweaning and postweaning periods than steam-flaked corn. In summary, it is recommended to incorporate canola meal with ground corn or soybean meal with steam-flaked corn in calf starters to enhance calf growth.

651. Multi-orbit lunar GNSS constellation design with distant retrograde orbit and Halo orbit combination.

Sci Rep

2023 Jun 22

Wang K, Li K, Lv S

The Moon is the closest natural satellite to mankind, with valuable resources on it, and is an important base station for mankind to enter deep space. How to establish a reasonable lunar Global Navigation Satellite System (GNSS) to provide real-time positioning, navigation, and timing (PNT) services for Moon exploration and development has become a hot topic for many international scholars. Based on the special spatial configuration characteristics of Libration point orbits (LPOs), the coverage capability of Halo orbits and Distant Retrograde Orbit (DRO) in LPOs is discussed and analyzed in detail. It is concluded that the Halo orbit with a period of 8 days has a better coverage effect on the lunar polar regions and the DRO has a more stable coverage effect on the lunar equatorial regions, and the multi-orbital lunar GNSS constellation with the optimized combination of DRO and Halo orbits is proposed by combining the advantages of both. This multi-orbital constellation can make up for the fact that a single type of orbit requires a larger number of satellites to fully cover the Moon, using a smaller number of satellites for the purpose of providing PNT services to the entire lunar surface. We designed simulation experiments to test whether the multi-orbital constellations meet the full lunar surface positioning requirements, and compare the coverage, positioning, and occultation effects of the four constellation designs that pass the test, and finally obtain a set of well-performing lunar GNSS constellations. The results indicate that the multi-orbital lunar GNSS constellation combining DRO and Halo orbits can cover 100% of the Moon surface, provides there are more than 4 visible satellites at any time on the Moon surface, which meets the navigation and positioning requirements, and the Position Dilution of Precision (PDOP) value is stable within 2.0, which can meet the demand for higher precision Moon surface navigation and positioning.

652. Data-driven models to predict shale wettability for CO(2) sequestration applications.

Sci Rep

2023 Jun 22

Ibrahim AF, Elkatatny S.

The significance of CO2 wetting behavior in shale formations has been emphasized in various CO2 sequestration applications. Traditional laboratory experimental techniques used to assess shale wettability are complex and time-consuming. To overcome these limitations, the study proposes the use of machine learning (ML); artificial neural networks (ANN), support vector machines (SVM), and adaptive neuro-fuzzy inference systems (ANFIS) tools to estimate the contact angle, a key indicator of shale wettability, providing a more efficient alternative to conventional laboratory methods. A dataset comprising various shale samples under different conditions was collected to predict shale-water-CO2 wettability by considering shale properties, operating pressure and temperature, and brine salinity. Pearson's correlation coefficient (R) was utilized to assess the linearity between the contact angle (CA) value and other input parameters. Initial data analysis showed that the elements affecting the shale wettability are primarily reliant on the pressure and temperature at which it operates, the total organic content (TOC), and the mineral composition of the rock. Between the different ML models, the artificial neural network (ANN) model performed the best, achieving a training R2 of 0.99, testing R2 of 0.98 and a validation R2 of 0.96, with an RMSE below 5. The adaptive neuro-fuzzy inference system (ANFIS) model also accurately predicted the contact angle, obtaining a training R2 of 0.99, testing R2 of 0.97 and a validation R2 of 0.95. Conversely, the support vector machine (SVM) model displayed signs of overfitting, as it achieved R2 values of 0.99 in the training dataset, which decreased to 0.94 in the testing dataset, and 0.88 in the validation dataset. To avoid rerunning the ML models, an empirical correlation was developed based on the optimized weights and biases obtained from the ANN model to predict contact angle values using input parameters and the validation data set revealed R2 of 0.96. The parametric study showed that, among the factors influencing shale wettability at a constant TOC, pressure had the most significant impact, and the dependency of the contact angle on pressure increased when TOC values were high.

653. 5-Aminolevulinic acid increases boronophenylalanine uptake into glioma stem cells and may sensitize malignant glioma to boron neutron capture therapy.

Sci Rep

2023 Jun 22

Fukumura M, Nonoguchi N, Kawabata S

654. Prognosis of patients with systemic sclerosis-related interstitial lung disease on the lung transplant waiting list: a retrospective study.

Sci Rep

2023 Jun 22

Nakayama Y, Nakashima R, Handa T

655. Prevalence and factors associated with severe undernutrition among under-5 children in Bangladesh, Pakistan, and Nepal: a comparative study using multilevel analysis.

Sci Rep

2023 Jun 22

Chowdhury MRK, Rahman MS, Billah B

656. An exceptionally well-preserved monodominant fossil forest of Wataria from the lower Miocene of Japan.

Sci Rep

2023 Jun 22

Nishino M, Terada K, Uemura K

657. The electrical properties of isolated microtubules.

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2023 Jun 22

Gutierrez BC, Cantiello HF, Cantero MDR.

658. Cyclophilin B serum levels present variations across the menstrual cycle.

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2023 Jun 22

Alvariño R, Gil-Mouce C, Botana MA

659. Interaction between retinol intake and ISX rs5755368 polymorphism in colorectal cancer risk: a case-control study in a Korean population.

Sci Rep

2023 Jun 22

Bui AQ, Gunathilake M, Lee J

660. Enteral administration of the protease inhibitor gabexate mesilate preserves vascular function in experimental trauma/hemorrhagic shock.

Sci Rep

2023 Jun 22

J D Moreira N, Dos Santos F, Li JB

Preserving vascular function is crucial for preventing multiorgan failure and death in ischemic and low-pressure states such as trauma/hemorrhagic shock (T/HS). It has recently been reported that inhibiting circulating proteases released from the bowel to the circulation during T/HS may preserve vascular function and improve outcomes following T/HS. This study aimed to evaluate the role of the serine protease inhibitor gabexate mesilate (GM) in preserving vascular function during T/HS when given enterally. We studied the vascular reactivity of mesenteric arteries from male Wistar rats treated with enteral GM (10 mg/kg) (GM-treated, n = 6) or control (Shock-control, n = 6) following (T/HS) using pressure myography. Concentration-response curves of endothelial-dependent and endothelial-independent agonists (e.g., acetylcholine, sodium nitroprusside) ranging from 10-10 to 10-5 M were performed. In a second set of experiments, ex-vivo arteries from healthy rats were perfused with plasma from shocked animals from both groups and vascular performance was similarly measured. Arteries from the GM-treated group demonstrated a preserved concentration-response curve to the α1 adrenergic agonist phenylephrine compared to arteries from Shock-control animals (- logEC50: - 5.73 ± 0.25 vs. - 6.48 ± 0.2, Shock-control vs. GM-treated, p = 0.04). When perfused with plasma from GM-treated rats, healthy arteries exhibited an even greater constriction and sensitivity to phenylephrine (- logEC50: - 6.62 ± 0.21 vs. - 7.13 ± 0.21, Shock-control vs. GM-treated, p = 0.02). Enteral GM also preserved the endothelium-dependent vascular response to agonists following T/HS and limited syndecan-1 shedding as a marker of glycocalyx compromise (41.84 ± 9 vs. 17.63 ± 3.97 ng/mL, Shock-control vs. GM-treated, p = 0.02). Syndecan-1 cleavage was correlated with plasma trypsin-like activity (r2 = 0.9611). Enteral gabexate mesilate was able to maintain vascular function in experimental T/HS, which was reflected by improved hemodynamics (mean arterial pressure 50.39 ± 7.91 vs. 64.95 ± 3.43 mmHg, Shock-control vs. GM treated, p = 0.0001). Enteral serine protease inhibition may be a potential therapeutic intervention in the treatment of T/HS.

661. A feasibility study on AI-controlled closed-loop electrical stimulation implants.

Sci Rep

2023 Jun 22

Eickhoff S, Garcia-Agundez A, Haidar D

662. Development of a novel air-liquid interface airway tissue equivalent model for in vitro respiratory modeling studies.

Sci Rep

2023 Jun 22

Leach T, Gandhi U, Reeves KD

663. Event trigger based adaptive neural trajectory tracking finite time control for underactuated unmanned marine surface vessels with asymmetric input saturation.

Sci Rep

2023 Jun 22

Hu Y, Zhang Q, Liu Y

664. Into the void: ECM fungal communities involved in the succession from rockroses to oak stands.

Sci Rep

2023 Jun 21

Sanz-Benito I, Stadler T, Mediavilla O

665. Effect of Lactobacillus delbrueckii subsp. lactis on vaginal radiotherapy for gynecological cancer.

Sci Rep

2023 Jun 21

Bi Z(#), Wang Q(#), Yang T

666. Correlation between sedentary activity, physical activity and bone mineral density and fat in America: National Health and Nutrition Examination Survey, 2011-2018.

Sci Rep

2023 Jun 21

Lin Z(#), Shi G(#), Liao X(#)

We compared the relationship between sedentary activity (SA) and physical activity (PA) with bone mineral density (BMD) and body fat percentage in the United States and found a negative association between SA and BMD and a positive association with body fat percentage. A positive association between PA and BMD and a negative association with body fat percentage. SA and PA are associated with changes in skeletal parameters and body fat percentage, and we aimed to investigate and compare the relationship between SA, PA and bone mineral density (BMD) and body fat percentage in men and women. We assessed the relationship between SA, PA and BMD and body fat percentage in 9787 Americans aged 20-59 years (mean age 38.28 ± 11.39 years) from NHANES 2011-2018. BMD and body fat percentage were measured by dual-energy X-ray bone densitometry (DXA). We used multiple linear regression models to examine the relationships between SA, PA and lumbar spine BMD and total body fat percentage, adjusted for a large number of confounding factors. After adjusting for race/ethnicity, age, alcohol and smoking behavior, body mass index (BMI), total protein, blood calcium, blood uric acid, cholesterol, blood phosphorus, vitamin D, and blood urea nitrogen, SA was negatively associated with lumbar spine BMD (β = - 0.0011 95% CI - 0.0020 to - 0.0002, P = 0.022), and SA was positively associated with total fat percentage (β = PA was positively associated with lumbar BMD (β = 0.0046 95% CI 0.0010 to 0.0082, P = 0.012) and there was a negative association between PA and body fat percentage (β = - 1.177 95% CI - 1.326 to -1.027, P < 0.001). Our results show that physical activity is a key component of maintaining bone health in both men and women and is strongly associated with lower body fat percentages. Sedentary activity is negatively correlated with bone density and is strongly associated with an increase in body fat percentage. Healthcare policy makers should consider reducing sedentary activity and increasing physical activity when preventing osteoporosis and obesity.

667. Identifying the regional drivers of influenza-like illness in Nova Scotia, Canada, with dominance analysis.

Sci Rep

2023 Jun 21

Aydede Y, Ditzen J.

668. Cuckoo search algorithm based on cloud model and its application.

Sci Rep

2023 Jun 21

Xiong Y, Zou Z, Cheng J.

669. Application of systems biology to identify pharmacological mechanisms of thrombotic microangiopathy evoked by combined activated prothrombin complex concentrate and emicizumab.

Sci Rep

2023 Jun 21

Valls R, Wagg J, Paz-Priel I

670. In silico mutagenesis-based designing of oncogenic SHP2 peptide to inhibit cancer progression.

Sci Rep

2023 Jun 21

Shahab M, Khan SS, Zulfat M

671. A prediction model for childhood obesity risk using the machine learning method: a panel study on Korean children.

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2023 Jun 21

Lim H, Lee H, Kim J.

672. Transformation of bimetallic Ag-Cu thin films into plasmonically active composite nanostructures.

Sci Rep

2023 Jun 21

Łapiński M, Kozioł R, Skubida W

673. Obesity paradox as a new insight from postoperative complications in gastric cancer.

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2023 Jun 21

Kamiya H(#), Komatsu S(#), Nishibeppu K

674. Transcriptomic analysis identifies novel candidates in cardiorenal pathology mediated by chronic peritoneal dialysis.

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2023 Jun 21

Nasci VL, Liu P, Marks AM

675. Development of CuMn(x)O(y) (x = 2, and y = 4)-GO heterostructure for the synthesis of pyranoquinoline derivatives.

Sci Rep

2023 Jun 21

Farajollahi A, Noroozi Pesyan N, Poursattar Marjani A

676. Tumor localization by Prostate Imaging and Reporting and Data System (PI-RADS) version 2.1 predicts prognosis of prostate cancer after radical prostatectomy.

Sci Rep

2023 Jun 21

Fujimoto A, Sakamoto S, Horikoshi T

677. Self-reported and accelerometer-based assessment of physical activity in older adults: results from the Berlin Aging Study II.

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2023 Jun 21

Vetter VM, Özince DD, Kiselev J

Physical activity (PA) has a substantial impact on health and mortality. Besides questionnaires that rely on subjective assessment of activity levels, accelerometers can help to objectify an individual's PA. In this study, variables estimating PA and sleep time obtained through the wGT3X-BT activity monitor (ActiGraph LLC, USA) in 797 participants of the Berlin Aging Study II (BASE-II) were analyzed. Self-reports of PA and sleep time were recorded with Rapid Assessment of Physical Activity (RAPA) and the Pittsburgh Sleep Quality Index sleep questionnaire (PSQI). Total cholesterol (TC), high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C), triglycerides (TG), fasting glucose, and hemoglobin A1c (HbA1c) were determined in an accredited standard laboratory. Of all participants, 760 fulfilled the PA wear-time criteria. In this sample mean age was 75.6 years (SD: 3.8 years, range 66.0-94.1 years) and 53% of the included participants were women. Average wear time was 23.2 h/day (SD 1.3 h/day). Statistically significant differences between RAPA groups were found for all accelerometric variables except energy expenditure. Post-hoc analysis, however, suggested low agreement between subjective and device-based assessment of physical activity. TC, HDL-C, LDL-C, TG, fasting glucose and HbA1c were weakly correlated with accelerometric variables (Pearson's r ≤ 0.25). Device-based average sleep time per night (mean sleep time = 6.91 h, SD = 1.3, n = 720) and self-reported average sleep time per night (mean sleep time = 7.1 h, SD = 1.15 h, n = 410) were in a comparable range and moderately correlated (Pearson's r = 0.31, p < 0.001, n = 410). Results from this study suggest that self-reported PA obtained through the RAPA and device-based measures assessed by accelerometers are partially inconsistent in terms of the physical activity level of the participants. Self-reported and device-based measures of average sleep time per night, however, were comparable.

678. Research on electromagnetic characteristics of traction motor rotary shafts with variable parameter defects based on finite element method.

Sci Rep

2023 Jun 21

Song M, Li M, Song X

679. Modifying Pavlovian-to-instrumental transfer by approach avoidance training in healthy subjects: a proof of concept study.

Sci Rep

2023 Jun 21

Rosenthal A, Chen K, Beck A

680. Transcriptome changes during osteogenesis of porcine mesenchymal stem cells derived from different types of synovial membranes and genetic background.

Sci Rep

2023 Jun 21

Li S, Siengdee P, Oster M

681. Computational intelligence modeling of hyoscine drug solubility and solvent density in supercritical processing: gradient boosting, extra trees, and random forest models.

Sci Rep

2023 Jun 21

Ghazwani M, Begum MY.

682. Fractional calculus in mathematical oncology.

Sci Rep

2023 Jun 21

Alinei-Poiana T, Dulf EH, Kovacs L.

683. Validation of collaborative cyberspace virtual reality oculometry enhanced with near real-time spatial audio.

Sci Rep

2023 Jun 21

Maloca PM, Zarranz-Ventura J, Valmaggia P

684. A causal link between mental imagery and affect-laden perception of climate change related risks.

Sci Rep

2023 Jun 21

Karlsson H, Asutay E, Västfjäll D.

685. Robust statistical properties of T1 transitions in a multi-phase field model of cell monolayers.

Sci Rep

2023 Jun 21

Jain HP, Voigt A, Angheluta L.

686. Left atrial function index predicts poor outcome in STEMI patients treated with percutaneous coronary intervention.

Sci Rep

2023 Jun 21

Tang Y(#), Huang P(#), Liu Z

687. Explainable AI via learning to optimize.

Sci Rep

2023 Jun 21

Heaton H, Fung SW.

688. Interoceptive abilities facilitate taking another's spatial perspective.

Sci Rep

2023 Jun 21

Baiano C, Job X, Kirsch LP

689. FRET analysis of the temperature-induced structural changes in human TRPV3.

Sci Rep

2023 Jun 21

Kim J(#), Won J(#), Chung DK

690. Synthesis and numerical simulation of formamidinium-based perovskite solar cells: a predictable device performance at NIS-Egypt.

Sci Rep

2023 Jun 21

Elsayed MRA, Elseman AM, Abdelmageed AA

691. Peripheral blood cellular dynamics of rheumatoid arthritis treatment informs about efficacy of response to disease modifying drugs.

Sci Rep

2023 Jun 21

Hedman ÅK(#), Winter E(#), Yoosuf N

692. A universal tool for stability predictions of biotherapeutics, vaccines and in vitro diagnostic products.

Sci Rep

2023 Jun 21

Huelsmeyer M, Kuzman D, Bončina M

693. The impact of facial expression and communicative gaze of a humanoid robot on individual Sense of Agency.

Sci Rep

2023 Jun 21

Lombardi M(#), Roselli C(#), Kompatsiari K

694. Tuning of the magnetotransport properties of a spin-polarized 2D electron system using visible light.

Sci Rep

2023 Jun 21

D'Antuono M, Chen Y, Caruso R

695. Single-cell Raman microscopy with machine learning highlights distinct biochemical features of neutrophil extracellular traps and necrosis.

Sci Rep

2023 Jun 21

Lelliott PM, Hobro AJ, Pavillon N

696. The association between passive social network usage and depression/negative emotions with envy as a mediator.

Sci Rep

2023 Jun 21

Cheng W, Nguyen DN, Nguyen PNT.

697. Genome segment ratios change during whitefly transmission of two bipartite cassava mosaic begomoviruses.

Sci Rep

2023 Jun 21

Kennedy GG, Sharpee W, Jacobson AL

698. Usefulness of two-dimensional shear wave elastography in the assessment of non-alcoholic fatty liver disease in children and adolescents.

Sci Rep

2023 Jun 21

Yoon JS, Lim KJ, Hwang IT.

699. Serological and clinical associations of autoantibodies in Chinese patients with new-onset systemic lupus erythematosus.

Sci Rep

2023 Jun 21

Gong M, Dai L, Xie Z

700. Physicochemical parameters, sensory profile and concentration of volatile compounds and anthocyanins in beers brewed using potato variety with purple flesh.

Sci Rep

2023 Jun 21

Gasiński A, Kawa-Rygielska J, Kita A

701. Parahydrogen-induced polarization enables the single-scan NMR detection of a 236 kDa biopolymer at nanomolar concentrations.

Sci Rep

2023 Jun 21

Theiss F, Wienands L, Lins J

702. Pasteurization of human milk affects the miRNA cargo of EVs decreasing its immunomodulatory activity.

Sci Rep

2023 Jun 21

Torrez Lamberti MF, Parker LA, Gonzalez CF

703. Factors influencing oral microbiome analysis: from saliva sampling methods to next-generation sequencing platforms.

Sci Rep

2023 Jun 21

Bang E(#), Oh S(#), Ju U

704. Proteomic analysis of the effect of hemin in breast cancer.

Sci Rep

2023 Jun 21

Coló GP(#), Schweitzer K(#), Oresti GM

705. Clinical and radiological evaluation of surgical treatment of medial epicondyle fractures of humerus in children. A two-centre study.

Sci Rep

2023 Jun 21

Stelmach W, Beczkowski J, Zając P

706. HUBO and QUBO models for prime factorization.

Sci Rep

2023 Jun 21

Jun K, Lee H.

707. Prophylactic consequences of sodium salicylate nanoparticles in cisplatin-mediated hepatotoxicity.

Sci Rep

2023 Jun 21

Alkhalaf M, Mohamed NA, El-Toukhy SE.

708. Green-adapted spectrophotometric determination of fostemsavir based on selective bromophenol blue extraction; reduction of hazardous consumption using computational calculations.

Sci Rep

2023 Jun 21

Batubara AS, Ainousah BE, Gamal M

709. The effect of blocking immune checkpoints LAG-3 and PD-1 on human invariant Natural Killer T cell function.

Sci Rep

2023 Jun 21

Balasko AL, Kowatsch MM, Graydon C

710. Terfezia boudieri and Terfezia claveryi inhibit the LPS/IFN-γ-mediated inflammation in RAW 264.7 macrophages through an Nrf2-independent mechanism.

Sci Rep

2023 Jun 21

Dawood AS, Sedeek MS, Farag MA

Desert truffles have been used as traditional treatments for numerous inflammatory disorders. However, the molecular mechanisms underlying their anti-inflammatory effects in RAW 264.7 macrophages have yet to be fully elucidated. The present study investigated the anti-inflammatory activities of two main desert truffles, Terfezia boudieri and T. claveryi, and the underlying mechanisms associated with their anti-inflammatory activities in RAW 264.7 macrophages stimulated with lipopolysaccharide/interferon-gamma (LPS/IFN-γ). Our results demonstrated that treatment with T. boudieri and T. claveryi extracts effectively suppressed the inflammatory response in LPS/IFN-γ-stimulated RAW 264.7 macrophages. Specifically, T. boudieri extract was found to reduce the production of nitric oxide and inhibit the expression of various pro-inflammatory markers, including inducible nitric oxide synthase, cyclooxygenase-2 (COX-2), tumor necrosis factor-α, and interleukin-6 (IL-6) at both the mRNA and protein levels. Similarly, T. claveryi extract exhibited comparable inhibitory effects, except for the expression of IL-6 and COX-2 at the protein level, where no significant effect was observed. Moreover, both studied extracts significantly downregulated the microRNA expression levels of miR-21, miR-146a, and miR-155, suggesting that T. boudieri and T. claveryi suppress the inflammatory response in LPS/IFN-γ-stimulated RAW 264.7 cells through an epigenetic mechanism. Furthermore, our study reveals a new mechanism for the anti-inflammatory properties of desert truffle extracts. We show for the first time that Terfezia extracts do not rely on the nuclear factor erythroid 2-related factor 2 pathway, previously linked to anti-inflammatory responses. This expands our understanding of natural product anti-inflammatory mechanisms and could have important implications for developing new therapies. To account for differences in truffle effects, extracts prepared were subjected to secondary metabolites profiling using UPLC-MS. UPLC-MS led to the annotation of 87 secondary metabolites belonging to various classes, including amino acids, carbohydrates, alkaloids, amides, fatty acids, sterols, and phenolic compounds. Therefore, these results indicate that T. boudieri and T. claveryi exhibit anti-inflammatory activities through suppressing multiple inflammatory mediators and cytokines and may be potential anti-inflammatory agents.

711. Predicting merchant future performance using privacy-safe network-based features.

Sci Rep

2023 Jun 21

Bahrami M(#), Boz HA(#), Suhara Y

712. Prognostic impact of blood urea nitrogen to albumin ratio on patients with sepsis: a retrospective cohort study.

Sci Rep

2023 Jun 20

Wang Y, Gao S, Hong L

713. A screening method for cervical myelopathy using machine learning to analyze a drawing behavior.

Sci Rep

2023 Jun 20

Yamada E, Fujita K, Watanabe T

714. Poly (A)-specific ribonuclease deficiency impacts oogenesis in zebrafish.

Sci Rep

2023 Jun 20

Nanjappa DP, De Saffel H, Kalladka K

715. Stability analysis and selection of sugar beet (Beta vulgaris L.) genotypes using AMMI, BLUP, GGE biplot and MTSI.

Sci Rep

2023 Jun 20

Taleghani D, Rajabi A, Saremirad A

716. An investigation into the robustness of a double-ended wideband impedance-based fault location technique.

Sci Rep

2023 Jun 20

Jahanger HK, Thomas DWP, Sumner M.

717. Application of additional three-dimensional materials for education in pediatric anatomy.

Sci Rep

2023 Jun 20

Youn JK(#), Park HS(#), Ko D

718. Adaptation of yeast Saccharomyces cerevisiae to grape-skin environment.

Sci Rep

2023 Jun 20

Watanabe D, Hashimoto W.

719. Sex-specific effects of Cre expression in Syn1Cre mice.

Sci Rep

2023 Jun 20

Baghdadi M, Mesaros A, Purrio M

720. Effects of horizontal compared to vertical-based plyometric jump training on semi-professional soccer player's performance.

Sci Rep

2023 Jun 20

Nobari H, Clemente FM, Vali N

721. Design and fabrication of a super-wideband transparent antenna implanted on a solar cell substrate.

Sci Rep

2023 Jun 20

Rohaninezhad M, Jalali Asadabadi M, Ghobadi C

722. A comparison of performance between a deep learning model with residents for localization and classification of intracranial hemorrhage.

Sci Rep

2023 Jun 20

Angkurawaranon S, Sanorsieng N, Unsrisong K

723. Mapping gut parasitism patterns in a cohort of Egyptians.

Sci Rep

2023 Jun 20

El-Wakil ES, Zalat RS, El-Badry AA.

In developing countries, the prevalence of intestinal parasitic infection is still significant, particularly due to geographical and socioeconomic variables. The objective of this study was to map the distribution pattern of intestinal parasitic infection in a cohort of the Egyptian population, as well as to assess associated risk factors. A cross-sectional hospital-based study was conducted on 386 patients. A single fecal specimen was collected from the study individual and examined microscopically for the detection of parasitic infection. DNA was extracted from all samples and utilized to amplify Entamoeba histolytica complex species, Cryptosporidium species, Giardia intestinalis assemblages, and Blastocystis species using PCRs. Typing of Cryptosporidium species and Giardia intestinalis assemblages was performed using restriction enzymes RasI and HaeIII respectively. While Blastocystis spp. subtypes (ST) were identified through sequencing of PCR products and phylogenetic analysis. 59.6% (230/386) of the study patients were infected with one or more intestinal parasites, 87.4%; 201/230 of patients had mono-parasitic infections, and 12.6%; 29/230 had multiple-parasitic infections (P < 0.0001). The predominant protozoa were Blastocystis, followed by Entamoeba histolytica complex, and Giardia intestinalis both as mono-parasites and as part of multiple parasites. Molecular assays showed that Blastocystis ST3, Entamoeba dispar, Giardia intestinalis assemblage B, and Cryptosporidium hominis were the most prevalent species. Intestinal parasitic infection was significantly associated with age, gender, residence, and water source. Multi-parasitism showed that residency in a rural area was a risk factor (OR 4.49; 95% CI 1.51-13.37; P = 0.007). Egyptians residing in rural areas have a high prevalence of intestinal multi-parasitism. Therefore, to lessen the prevalence and effects of these infections in this group, effective and sustainable control methods, providing health education focusing on good personal hygiene habits, and providing a safe drinking water supply should be implemented.

724. Ce(III) and La(III) ions adsorption using Amberlite XAD-7 resin impregnated with DEHPA extractant: response surface methodology, isotherm and kinetic study.

Sci Rep

2023 Jun 20

Yarahmadi A, Khani MH, Nasiri Zarandi M

725. Nerve conduction studies through landmark based recording and effects of hand length.

Sci Rep

2023 Jun 20

Yaranagula SD, Koduri VKC, Babu PS

726. Transcriptomics-driven drug repositioning for the treatment of diabetic foot ulcer.

Sci Rep

2023 Jun 20

Adikusuma W, Zakaria ZA, Irham LM

727. Vulnerability of cocoa-based agroforestry systems to climate change in West Africa.

Sci Rep

2023 Jun 20

Ariza-Salamanca AJ, Navarro-Cerrillo RM, Quero-Pérez JL

728. Climate resilience of dry season cereals in India.

Sci Rep

2023 Jun 20

DeFries R, Liang S, Chhatre A

729. Design, synthesis, in vitro anti-α-glucosidase evaluations, and computational studies of new phthalimide-phenoxy-1,2,3-triazole-N-phenyl (or benzyl) acetamides as potential anti-diabetic agents.

Sci Rep

2023 Jun 20

Emadi M, Halimi M, Moazzam A

730. Preverbal infants produce more protophones with artificial objects compared to natural objects.

Sci Rep

2023 Jun 20

Gibson V, Somogyi E, Nomikou I

731. A novel specific aptamer targets cerebrovascular endothelial cells after ischemic stroke.

Sci Rep

2023 Jun 20

Hu H, Wu S, Lee TJ

732. TGFβ inhibition and mesenchymal to epithelial transition initiation by Xenopus egg extract: first steps towards early reprogramming in fish somatic cell.

Sci Rep

2023 Jun 20

Chênais N, Le Cam A, Guillet B

733. Attributes of host-specificity better explain the diversified wood-boring longhorn beetles in tropical SW China than plant species diversity.

Sci Rep

2023 Jun 20

Luo F, Bibi F, Disayathanoowat T

734. Calculation of magnetocaloric effect with regard for dependence of heat capacity on magnetic field.

Sci Rep

2023 Jun 20

Kosogor A, L'vov VA.

735. Clinical feasibility of CS-VIBE accelerates MRI techniques in diagnosing intracranial metastasis.

Sci Rep

2023 Jun 20

Park SI, Yim Y, Chung MS.

736. A validated prognostic nomogram for patients with H3 K27M-mutant diffuse midline glioma.

Sci Rep

2023 Jun 20

Peng Y(#), Ren Y(#), Huang B

737. High-gain printed monopole antenna with dual-band characteristics using FSS-loading and top-hat structure.

Sci Rep

2023 Jun 20

Danuor P, Moon JI, Jung YB.

738. Evanescent wave in multiple slit diffraction and n-array antennas in metamaterial using Cesàro convergence.

Sci Rep

2023 Jun 20

Nellambakam Y, Haritha K, Shiv Chaitanya KVS.

739. A PETase enzyme synthesised in the chloroplast of the microalga Chlamydomonas reinhardtii is active against post-consumer plastics.

Sci Rep

2023 Jun 20

Di Rocco G, Taunt HN, Berto M

740. Controllable hybrid plasmonic integrated circuit.

Sci Rep

2023 Jun 20

Khodadadi M, Moshiri SMM, Nozhat N

741. Radiocesium-bearing microparticles discovered on masks worn during indoor cleaning.

Sci Rep

2023 Jun 20

Higaki S, Yoshida-Ohuchi H, Shinohara N.

742. Additive fabrication and experimental validation of a lightweight thermoelectric generator.

Sci Rep

2023 Jun 20

Fanciulli C, Abedi H, Nespoli A

743. Clinical and radiological efficacy of spino-pelvic fixation in the treatment of neuromuscular scoliosis.

Sci Rep

2023 Jun 20

Yang JH(#), Kim HJ(#), Chang DG

744. Inhibitory effect of β-escin on Zika virus infection through the interruption of viral binding, replication, and stability.

Sci Rep

2023 Jun 20

Lai ZZ, Shen HH, Lee YM.

745. Methylboronic acid MIDA ester (ADM) as an effective additive in electrolyte to improve cathode electrolyte interlayer performance of LiNi(0.8)Co(0.15)Al(0.05)O(2) electrode.

Sci Rep

2023 Jun 20

Chen BX(#), Brahma S(#), Chen YQ

746. Sources of variability in seagrass fatty acid profiles and the need of identifying reliable warming descriptors.

Sci Rep

2023 Jun 20

Pansini A, Beca-Carretero P, González MJ

747. A validated model for individualized prediction of pregnancy outcome in woman after fresh cycle of Day 5 single blastocyst transfer.

Sci Rep

2023 Jun 20

Chen L(#), Jiang R(#), Jiang Y

748. Mid- to late Holocene sea-level rise recorded in Hells Bells (234)U/(238)U ratio and geochemical composition.

Sci Rep

2023 Jun 20

Schorndorf N, Frank N, Ritter SM

749. County augmented transformer for COVID-19 state hospitalizations prediction.

Sci Rep

2023 Jun 20

Er S, Yang S, Zhao T.

750. Booster effect of the third dose of SARS-CoV-2 mRNA vaccine in Japanese kidney transplant recipients.

Sci Rep

2023 Jun 20

Kawabe M(#), Kuroda T(#), Yamamoto I

751. Determination of the effect of abiotic stress on the oxidative potential of edible potato tubers.

Sci Rep

2023 Jun 20

Wszelaczyńska E(#), Pobereżny J(#), Gościnna K

752. Novel synthesis of siligraphene/tungstates (g-SiC/AWO) with promoted transportation of photogenerated charge carriers via direct Z-scheme heterojunctions.

Sci Rep

2023 Jun 20

Afsharpour M, Darvishi-Farash S.

753. Comparison of planned versus achieved central corneal stromal thickness reduction in SMILE versus FS-LASIK: a retrospective study.

Sci Rep

2023 Jun 20

Lu X(#), Fan Y(#), Liu Z

754. Causal factors in primary open angle glaucoma: a phenome-wide Mendelian randomisation study.

Sci Rep

2023 Jun 20

Julian TH, Girach Z, Sanderson E

755. Momentum transfer on impact damping by liquid crystalline elastomers.

Sci Rep

2023 Jun 20

Guo H, Terentjev A, Saed MO

756. Evaluation of immunoserological detection of anti-liver kidney microsomal, anti-soluble liver antigen and anti-mitochondrial antibodies.

Sci Rep

2023 Jun 20

Campos-Murguia A, Henjes N, Loges S

757. Circulating extracellular vesicle-derived MARCKSL1 is a potential diagnostic non-invasive biomarker in metastatic colorectal cancer patients.

Sci Rep

2023 Jun 20

Rong W, Shao S, Pu Y

758. Frequency and characteristics of patients with bispectral index values of 60 or higher during the induction and maintenance of general anesthesia with remimazolam.

Sci Rep

2023 Jun 20

Choi BM, Lee JS, Kim KM

759. Transcranial magnetic stimulation of the left middle frontal gyrus modulates the information people communicate in different social contexts.

Sci Rep

2023 Jun 20

Martín-Luengo B, Vorobiova AN, Feurra M

760. Greater intramuscular adipose tissue of the quadriceps in older inpatients at post-acute hospital admission is more strongly related to a low rate of home discharge than a loss of muscle mass.

Sci Rep

2023 Jun 20

Akazawa N, Funai K, Hino T

761. Data mining on identifying diagnosis and prognosis biomarkers in head and neck squamous carcinoma.

Sci Rep

2023 Jun 20

Ju G(#), Yao Z(#), Zhao Y

762. The characterization of collagen-based scaffolds modified with phenolic acids for tissue engineering application.

Sci Rep

2023 Jun 20

Kaczmarek-Szczepańska B, Polkowska I, Małek M

763. Characterization of two novel lytic bacteriophages having lysis potential against MDR avian pathogenic Escherichia coli strains of zoonotic potential.

Sci Rep

2023 Jun 20

Sattar S, Bailie M, Yaqoob A

764. Controlling grain structure in metallic additive manufacturing using a versatile, inexpensive process control system.

Sci Rep

2023 Jun 20

Chechik L, Goodall AD, Christofidou KA

765. Enhancement in mechanical and antimicrobial properties of epoxidized natural rubber via reactive blending with chlorhexidine gluconate.

Sci Rep

2023 Jun 20

Kanthiya T, Thajai N, Chaiyaso T

766. Differential expression of Dusp1 and immediate early response genes in the hippocampus of rats, subjected to forced swim test.

Sci Rep

2023 Jun 20

Vlasov I, Filatova E, Slominsky P

767. CHI3L1 induces autophagy through the JNK pathway in lung cancer cells.

Sci Rep

2023 Jun 20

Hong DE(#), Yu JE(#), Yoo SS

768. EEG repetition and change detection responses in infancy predict adaptive functioning in preschool age: a longitudinal study.

Sci Rep

2023 Jun 20

Deguire F, López-Arango G, Knoth IS

769. Characterization and outlook of climatic hazards in an agricultural area of Pakistan.

Sci Rep

2023 Jun 20

Bhatti MT, Anwar AA, Hussain K.

770. Maternal weight latent trajectories and associations with adverse pregnancy outcomes using a smoothing mixture model.

Sci Rep

2023 Jun 2

Faraji Azad S, Biglarian A, Rostami M

Class membership is a critical issue in health data sciences. Different types of statistical models have been widely applied to identify participants within a population with heterogeneous longitudinal trajectories. This study aims to identify latent longitudinal trajectories of maternal weight associated with adverse pregnancy outcomes using smoothing mixture model (SMM). Data were collected from the Khuzestan Vitamin D Deficiency Screening Program in Pregnancy. We applied the data of 877 pregnant women living in Shooshtar city, whose weights during the nine months of pregnancy were available. In the first step, maternal weight was classified and participants were assigned to only one group for which the estimated trajectory is the most similar to the observed one using SMM; then, we examined the associations of identified trajectories with risk of adverse pregnancy endpoints by applying logistic regression. Three latent trajectories for maternal weight during pregnancy were identified and named as low, medium and high weight trajectories. Crude estimated odds ratio (OR) for icterus, preterm delivery, NICU admission and composite neonatal events shows significantly higher risks in trajectory 1 (low weight) compared to trajectory 2 (medium weight) by 69% (OR = 1.69, 95%CI 1.20, 2.39), 82% (OR = 1.82, 95%CI 1.14, 2.87), 77% (OR = 1.77, 95%CI 1.17, 2.43), and 85% (OR = 1.85, 95%CI 1.38, 2.76), respectively. Latent class trajectories of maternal weights can be accurately estimated using SMM. It is a powerful means for researchers to appropriately assign individuals to their class. The U-shaped curve of association between maternal weight gain and risk of maternal complications reveals that the optimum place for pregnant women could be in the middle of the growth curve to minimize the risks. Low maternal weight trajectory compared to high had even a significantly higher hazard for some neonatal adverse events. Therefore, appropriate weight gain is critical for pregnant women.Trial registration International Standard Randomized Controlled Trial Number (ISRCTN): 2014102519660N1; http://www.irct.ir/searchresult.php?keyword=&id=19660&number=1&prt=7805&total=10&m=1 (Archived by WebCite at http://www.webcitation.org/6p3lkqFdV ).

771. Ultra-high performance liquid chromatography high-resolution mass spectrometry for metabolomic analysis of dental calculus from Duke Alessandro Farnese and Maria D'Aviz.

Sci Rep

2023 Jun 2

Riboni N, Bianchi F, Mattarozzi M

772. Green hematite depression for reverse selective flotation separation from quartz by locust bean gum.

Sci Rep

2023 Jun 2

Kordloo M, Khodadadmahmoudi G, Ebrahimi E

773. Stimulus specific cortical activity associated with ignoring distraction during working memory encoding and maintenance.

Sci Rep

2023 Jun 2

Ashton C, Gouws AD, Glennon M

774. Quantification of active bearing input force for vibration reduction performance of unbalanced rotor systems.

Sci Rep

2023 Jun 2

Hong D, Lee H, Han Y

775. Quantifiable peptide library bridges the gap for proteomics based biomarker discovery and validation on breast cancer.

Sci Rep

2023 Jun 2

Kim SS(#), Shin H(#), Ahn KG

776. Preparation and evaluation of some nanocarbon (NC) based composites for optoelectronic applications.

Sci Rep

2023 Jun 2

Elhalawany N, Abdel-Karim AM, Saleeb MM.

Polyaniline/nanocarbon (PANI/NC) nanocomposites have been prepared by in situ polymerization of aniline monomer in the presence of a stable colloidal solution of nanocarbon NC using ammonium persulfate as an initiator and silver ions (Ag+) as oxidizing agents to produce PANI/NC and PANI/NC/Ag2O nanocomposites, respectively. The morphological studies of the formed nanocomposites have been elucidated via transmission and scanning electron microscopes (TEM and SEM). Further characterization of the prepared nanocomposites has been done via infrared spectroscopy (IR), X-ray diffractometer (XRD), X-ray photoelectron spectroscopy (XPS), particle size distribution analysis (PSD), fluorescence microscope (FM), UV-VIS spectroscopy, and finally surface analysis. XRD results confirmed the presence of silver oxide Ag2O nanoparticles, and the obtained data is well matched with the JCPDS card number 76-1393 of silver oxide. XPS analyses have shown two prevailing characteristic peaks for Ag 3d5/2 and Ag 3d3/2 at 367.1 and 373 eV, respectively, representing Ag2O nanoparticles, which are matchable with the XRD analysis. The PSD analysis revealed that the sizes of the prepared nanocomposites are in the size range from 60 to 140 nm. The FM measurements showed luminescence from the prepared nanocomposites upon irradiation with different lights. This recommends that the fluorophores present in the prepared nanocomposites have the potential to both absorb and emit light. The AC conductivity and the dielectric permittivity of the obtained nanocomposites at room temperature and at different frequency ranges have been investigated. At higher frequency ranges, the maximum ac conductivity obtained was 1.06 × 10-2 and 2.5 × 10-2 S.Cm-1 for the PANI/NC and PANI/NC/Ag2O, respectively. As far as we know, these new nanocomposites with superior optical and electrical characteristics have not been described yet in the literature.

777. A pan-cancer analysis of the role of USP5 in human cancers.

Sci Rep

2023 Jun 2

Yan B, Guo J, Deng S

778. Isolation of saprophytic filamentous fungi from avian fecal samples and assessment of its predatory activity on coccidian oocysts.

Sci Rep

2023 Jun 2

Lozano J, Louro M, Almeida C

779. Importance of depth and temperature variability as drivers of coral symbiont composition despite a mass bleaching event.

Sci Rep

2023 Jun 2

de Souza MR, Caruso C, Ruiz-Jones L

780. Machine learning explainability in nasopharyngeal cancer survival using LIME and SHAP.

Sci Rep

2023 Jun 2

Alabi RO, Elmusrati M, Leivo I

Nasopharyngeal cancer (NPC) has a unique histopathology compared with other head and neck cancers. Individual NPC patients may attain different outcomes. This study aims to build a prognostic system by combining a highly accurate machine learning model (ML) model with explainable artificial intelligence to stratify NPC patients into low and high chance of survival groups. Explainability is provided using Local Interpretable Model Agnostic Explanations (LIME) and SHapley Additive exPlanations (SHAP) techniques. A total of 1094 NPC patients were retrieved from the Surveillance, Epidemiology, and End Results (SEER) database for model training and internal validation. We combined five different ML algorithms to form a uniquely stacked algorithm. The predictive performance of the stacked algorithm was compared with a state-of-the-art algorithm-extreme gradient boosting (XGBoost) to stratify the NPC patients into chance of survival groups. We validated our model with temporal validation (n = 547) and geographic external validation (Helsinki University Hospital NPC cohort, n = 60). The developed stacked predictive ML model showed an accuracy of 85.9% while the XGBoost had 84.5% after the training and testing phases. This demonstrated that both XGBoost and the stacked model showed comparable performance. External geographic validation of XGBoost model showed a c-index of 0.74, accuracy of 76.7%, and area under curve of 0.76. The SHAP technique revealed that age of the patient at diagnosis, T-stage, ethnicity, M-stage, marital status, and grade were among the prominent input variables in decreasing order of significance for the overall survival of NPC patients. LIME showed the degree of reliability of the prediction made by the model. In addition, both techniques showed how each feature contributed to the prediction made by the model. LIME and SHAP techniques provided personalized protective and risk factors for each NPC patient and unraveled some novel non-linear relationships between input features and survival chance. The examined ML approach showed the ability to predict the chance of overall survival of NPC patients. This is important for effective treatment planning care and informed clinical decisions. To enhance outcome results, including survival in NPC, ML may aid in planning individualized therapy for this patient population.

781. Kinematics and energetics of foraging behavior in Rice's whales of the Gulf of Mexico.

Sci Rep

2023 Jun 2

Kok ACM, Hildebrand MJ, MacArdle M

782. Increased plasma lipids in triple-negative breast cancer and impairment in HDL functionality in advanced stages of tumors.

Sci Rep

2023 Jun 2

Sawada MIBAC, de Fátima Mello Santana M, Reis M

The association between plasma lipids and breast cancer (BC) has been extensively explored although results are still conflicting especially regarding the relationship with high-density lipoprotein cholesterol (HDLc) levels. HDL mediates cholesterol and oxysterol removal from cells limiting sterols necessary for tumor growth, inflammation, and metastasis and this may not be reflected by measuring HDLc. We addressed recently diagnosed, treatment-naïve BC women (n = 163), classified according to molecular types of tumors and clinical stages of the disease, in comparison to control women (CTR; n = 150) regarding plasma lipids and lipoproteins, HDL functionality and composition in lipids, oxysterols, and apo A-I. HDL was isolated by plasma discontinuous density gradient ultracentrifugation. Lipids (total cholesterol, TC; triglycerides, TG; and phospholipids, PL) were determined by enzymatic assays, apo A-I by immunoturbidimetry, and oxysterols (27, 25, and 24-hydroxycholesterol), by gas chromatography coupled with mass spectrometry. HDL-mediated cell cholesterol removal was determined in macrophages previously overloaded with cholesterol and 14C-cholesterol. Lipid profile was similar between CTR and BC groups after adjustment per age. In the BC group, lower concentrations of TC (84%), TG (93%), PL (89%), and 27-hydroxicholesterol (61%) were observed in HDL, although the lipoprotein ability in removing cell cholesterol was similar to HDL from CRT. Triple-negative (TN) BC cases presented higher levels of TC, TG, apoB, and non-HDLc when compared to other molecular types. Impaired HDL functionality was observed in more advanced BC cases (stages III and IV), as cholesterol efflux was around 28% lower as compared to stages I and II. The altered lipid profile in TN cases may contribute to channeling lipids to tumor development in a hystotype with a more aggressive clinical history. Moreover, findings reinforce the dissociation between plasma levels of HDLc and HDL functionality in determining BC outcomes.

783. Simple new clinical score to predict hepatocellular carcinoma after sustained viral response with direct-acting antivirals.

Sci Rep

2023 Jun 2

Watanabe T, Tokumoto Y, Joko K

784. Ulam-Hyers stability of tuberculosis and COVID-19 co-infection model under Atangana-Baleanu fractal-fractional operator.

Sci Rep

2023 Jun 2

Selvam A, Sabarinathan S, Senthil Kumar BV

785. Underexplored and growing economic costs of invasive alien trees.

Sci Rep

2023 Jun 2

Fernandez RD, Haubrock PJ(#), Cuthbert RN(#)

786. Effects of the depletion of neural progenitors by focal X-ray irradiation on song production and perception in canaries.

Sci Rep

2023 Jun 2

Chiver I, Dos Santos EB, Valle S

787. Biosynthesis of Co(3)O(4) nanomedicine by using Mollugo oppositifolia L. aqueous leaf extract and its antimicrobial, mosquito larvicidal activities.

Sci Rep

2023 Jun 2

Gowthami P, Kosiha A, Meenakshi S

788. DEM modeling direct shearing behavior of sand considering anti-rotation of particle.

Sci Rep

2023 Jun 2

Wu L, Qian J, Xie L

789. TSH levels after fresh embryo transfer are associated with reproductive outcomes in euthyroid women undergoing the first IVF/ICSI cycles.

Sci Rep

2023 Jun 2

Zhang Y, Liu Y, Wu W

To investigate whether there is a relationship between TSH levels on the 14th day post embryo transfer (D14 TSH levels) and the reproductive outcomes in euthyroid women who are free from levothyroxine (LT4) treatment and undergo the first in vitro fertilization /intracytoplasmic sperm injection embryo transfer (IVF/ICSI-ET) cycles with the homogeneous ovarian stimulation protocols. This was a prospective study including a total of 599 euthyroid women undergoing the first IVF/ICSI ET cycles. Serum samples were collected and frozen on the 14th day post embryo transfer. TSH levels were measured after the confirmation of clinical pregnancy. The patients were divided into three groups (low-normal ≤ 2.5 mIU/L; high-normal 2.5-4.2 mIU/L; and high > 4.2 mIU/L) based on D14 TSH levels. Reproductive outcomes were compared among the three groups. Binary logistic regression analyses and generalized additive mixed models with smoothing splines were used to investigate the relationship between TSH levels and reproductive outcomes. D14 TSH levels were significantly elevated compared to basal TSH levels, and the degree of TSH elevation was significantly higher in pregnant women compared to that in non-pregnant women. The clinical pregnancy and live birth rates increased significantly in the high-normal D14 TSH groups, and doubled in the high D14 TSH groups compared to the low TSH groups. When adjusted by age, basal TSH, AMH, E2, endometrial thickness, type and causes of infertility, and transferred embryos, the dose-dependent relationships between D14 TSH and clinical pregnancy and live birth were observed. Obstetric outcomes in singleton or twins live birth among the different D14 TSH groups were similar. Elevated D14 TSH levels were associated with better clinical pregnancy and live birth rates, and were not associated with worse obstetric outcomes. The mechanisms to explain the phenomenon remained to be studied.

790. Effect of buoyancy loads on the tsunami fragility of existing reinforced concrete frames including consideration of blow-out slabs.

Sci Rep

2023 Jun 2

Del Zoppo M, Rossetto T, Di Ludovico M

791. Year-round spawning of three tropical Cypriniformes fishes in Southeast Asia.

Sci Rep

2023 Jun 2

Kahar R, Ahmad N, Arai T.

792. The causal mutation in ARR3 gene for high myopia and progressive color vision defect.

Sci Rep

2023 Jun 2

Gu L, Cong P, Ning Q

793. Human soluble CD39 displays substrate inhibition in a substrate-specific manner.

Sci Rep

2023 Jun 2

Vadlamani VMK, Gunasinghe KKJ, Chee XW

794. A method for parallel microscale protein labeling and precise control over the average degree of labeling (aDoL).

Sci Rep

2023 Jun 2

Ruan Q, Zhao C.

795. A new remarkable Early Cretaceous nelumbonaceous fossil bridges the gap between herbaceous aquatic and woody protealeans.

Sci Rep

2023 Jun 2

Gobo WV, Kunzmann L, Iannuzzi R

796. Estimation of mobility and population in Spain during different phases of the COVID-19 pandemic from mobile phone data.

Sci Rep

2023 Jun 2

Osorio Arjona J, de Las Obras-Loscertales Sampériz J.

797. Fabrication and characterization of graphene oxide-based polymer nanocomposite coatings, improved stability and hydrophobicity.

Sci Rep

2023 Jun 2

Kumar SSA, M NB, Batoo KM

798. A retrospective study of the accuracy of Invisalign Progress Assessment with clear aligners.

Sci Rep

2023 Jun 2

Li B, Xu YM, Shi RY

The objective of this study was to detective the accuracy of model superimposition and automatic analysis for upper and lower dentition width in Invisalign Progress Assessment during the process of clear aligners. 19 cases were included in this study. Pre-treatment dental cast (T0) and post-treatment dental cast after staged treatment (T1) were available for three-dimensional model superimposition. Subsequently, movements of maxillary teeth in the horizontal plane (cross-section) after staged treatment and width of upper and lower dentition were measured by three-dimensional model superimposition in the real world and Invisalign Progress Assessment separately. Consequently, the data collected from these two methods were compared. In Invisalign Progress Assessment, movements of maxillary teeth in the horizontal plane after staged treatment was 2.31 (1.59,3.22) [median (upper quartile, lower quartile)] millimeter (mm), while in three-dimensional model superimposition, the result was 1.79 (1.21,3.03) mm. The difference between the two groups is significant (P < 0.05). Intercanine width upper, intermolar width upper, intercanine width lower, and intermolar width lower were 36.55 ± 2.76 mm, 56.98 ± 2.62 mm, 28.16 ± 1.85 mm, 53.21 ± 2.72 mm separately in Invisalign Progress Assessment and were 36.48 ± 2.78 mm, 56.89 ± 2.58 mm, 28.05 ± 1.85 mm, 53.16 ± 2.64 mm separately in three-dimensional model analysis, which was no significant difference among these groups (P > 0.05). The data from Invisalign Progress Assessment was not in parallel with what was achieved from model superimposition with palate as a reference completely. The accuracy of model superimposition in Invisalign Progress Assessment needs further investigation, whereas the accuracy of model analysis in Invisalign Progress Assessment was accurate. Thereby, results from Invisalign Progress Assessment should be interpreted with caution by the orthodontist in the clinic.

799. Predicting the presence of tinnitus using ecological momentary assessments.

Sci Rep

2023 Jun 2

Breitmayer M, Stach M, Kraft R

800. Measuring vibrations on a biofidelic brain using ferroelectret nanogenerator.

Sci Rep

2023 Jun 2

Dsouza H, Dávila-Montero BM, Afanador IG

801. Reliability prediction and evaluation of communication base stations in earthquake prone areas.

Sci Rep

2023 Jun 2

Li X, Wei Y, Ming Z

802. Analysis of the impact of green urban areas in historic fortified cities using Landsat historical series and Normalized Difference Indices.

Sci Rep

2023 Jun 2

Moreno M, Ortiz P, Ortiz R.

803. No impacts of glyphosate or Crithidia bombi, or their combination, on the bumblebee microbiome.

Sci Rep

2023 Jun 2

Straw EA(#), Mesnage R(#), Brown MJF

804. Interpretable deep learning for diagnosis of fungal and acanthamoeba keratitis using in vivo confocal microscopy images.

Sci Rep

2023 Jun 2

Essalat M(#), Abolhosseini M(#), Le TH(#)

805. Refining the evolutionary tree of the horse Y chromosome.

Sci Rep

2023 Jun 2

Bozlak E, Radovic L, Remer V

806. Identification of serotypes of Mannheimia haemolytica and Pasteurella multocida from pneumonic cases of sheep and goats and their antimicrobial sensitivity profiles in Borana and Arsi zones, Ethiopia.

Sci Rep

2023 Jun 2

Girma S, Getachew L, Beyene A

Respiratory diseases caused by Mannheimia haemolytica (M. haemolytica) and Pasteurella multocida (P. multocida) have been known to result in a considerable loss due to mortality and reduced production. This study aimed at isolation and identification of M. haemolytica and P. multocida associated with pneumonic pasteurellosis in sheep and goats using bacteriological and molecular techniques. Identification of serotypes of M. haemolytica and P. multocida was done using indirect haemagglutination test. The in vitro antimicrobial sensitivity profiles of the M. haemolytica were tested using standard disk diffusion method. A total of 52 and 78 nasal swabs were collected from pneumonic cases for bacterial isolation and identification in Borana and Arsi zone, respectively. Four hundred sera samples were collected for identification of serotypes. The results showed that 17 of 52 (32.69%; 95% CI 20.33, 47.11) nasal swabs collected from pneumonic animals in Borana yielded positive results for Pasteurella/Mannheimia species, 13 (25.00%; 95% CI 14.03, 38.95) of which were M. haemolytica. None of the samples yielded P. multocida. Twenty-three of 78 (29.49%; 95% CI 19.69, 40.89) nasal swabs collected at Arsi from pneumonic animals yielded positive results for M. haemolytica (17) and P. multocida (6). Secondary biochemical characterization revealed that 14 of the 17 isolates conform to M. haemolytica whereas none of the 6 isolates suspected to be P. mutocida were confirmed. Eleven (84.62%) isolates from Borana and 4 (28.57%) from Arsi were confirmed to be M. haemolytica using PCR targeting the Rpt2 genes. Assay for M. haemolytica serotype A1 revealed all belong to A1. None of the isolates with cultural and morphological features of P. multocida gave positive results by molecular assay. Serological assay identified three serotypes of M. haemolytica namely A1, A2 and A7 almost in all of the samples whereas P. multocida serotype A was detected in 78.75% of the samples. The M. haemolytica isolates tested for susceptibility to antibiotics showed resistance against Bacitracin (83.33%) and Penicillin (50.00%) while they were found susceptible to Gentamycin (100%), Chloramphenicol (100%) and Sulfamethoxazole (100%) and Tetracycline (83.33%). In conclusion, the results of the present study revealed the association of M. haemolytica with pneumonic pasteurellosis in sheep and goats and can be of use in vaccine development in Ethiopia. Nevertheless, further investigations and continuous monitoring of antimicrobial resistance and appropriate selection and prudent use of antimicrobials in livestock sector are required.

807. Integrated bioinformatics analysis for identifying key genes and pathways in female and male patients with dilated cardiomyopathy.

Sci Rep

2023 Jun 2

Zhang M, Wang X, Chen W

808. Behavioral assays reveal mechanisms of supercolony formation in odorous house ants.

Sci Rep

2023 Jun 2

Buczkowski G, Wang S, Craig BA.

The formation of expansive multi-nest and multi-queen supercolonies is perhaps the most important factor responsible for the ecological success of invasive ants. The odorous house ant, Tapinoma sessile, is a widespread ant native to North America. T. sessile is a challenging urban pest, but also serves as an interesting system to study ant social organization and invasion biology. This is due to its remarkable dichotomy in colony social and spatial structure between natural and urban environments. Natural colonies typically consist of a small number of workers, inhabit a single nest, and are monogyne whereas urban colonies show extreme polygyny and polydomy and form large supercolonies. The current study examined the extent to which T. sessile colonies from different habitats (natural vs. urban) and social structures (monogynous vs. polygynous) exhibit aggression toward alien conspecifics. Additionally, interactions between mutually aggressive colonies were examined in colony fusion experiments to assess the potential role of colony fusion as a mechanism leading to supercolony formation. Aggression assays demonstrated high levels of aggression in pairings involving workers from different urban colonies and workers from different natural colonies, but low aggression in pairings involving queens from different urban colonies. Colony merging tests demonstrated that urban T. sessile colonies are highly aggressive to each other, but capable of fusing under laboratory conditions when competing for limited nesting and food resources. Despite highly aggressive interactions and relatively high worker and queen mortality, all colony pairs merged in 3-5 days. Fusion occurred after most workers died and the survivors merged. This result suggests that the success of T. sessile in urban areas may be driven, at least in part, by successful colony mergers of unrelated colonies which may be determined by ecological constraints such as seasonal shortages in nest and/or food availability. In summary, two independent factors including the growth of a single colony and/or the merger of multiple colonies may be responsible for the evolution of supercolonies in invasive ants. Both processes may be happening simultaneously and may act synergistically to produce supercolonies.

809. Determinants of arterial stiffness in patients with type 2 diabetes mellitus: a cross sectional analysis.

Sci Rep

2023 Jun 2

Staef M, Ott C, Kannenkeril D

In patients with type 2 diabetes mellitus (T2DM) arterial stiffness is associated with increased cardiovascular and total mortality. Little is known about determinants of arterial stiffness in clinical routine. Identification of potential determinants of arterial stiffness will help to address treatment targets for patients in the early state of T2DM. This is a cross-sectional analysis of arterial stiffness in 266 patients in the early stage of T2DM who did not have cardiovascular or renal complications. Parameters of arterial stiffness such as central systolic blood pressure (cSBP), central pulse pressure (cPP) and pulse wave velocity (PWV) were measured with the SphygmoCor System (AtCor Medical). We investigated the influence of parameters of glucose metabolism, lipid status, body constitution, blood pressure (BP) and inflammation on the stiffness parameters using multivariate regression analysis. The study cohort consisted of male and female patients aged 61 ± 8 years with mean diabetes duration of 6.4 ± 5.1 years, mean HbA1c 7.1 ± 0.9%, mean cSBP 121 ± 12 mmHg, mean cPP 44 ± 10 mmHg and mean PWV 8.9 ± 1.8 m/s. Multiple regression analysis identified waist circumference (WC) (beta = 0.411, p = 0.026), LDL-cholesterol (beta = 0.106, p = 0.006), systolic office BP (beta = 0.936, p < 0.001) and diabetes duration (beta = 0.233, p = 0.043) as potential determinants of cSBP. cPP was determined by sex (beta = 0.330, p = 0.008), age (beta = 0.383, p < 0.001), systolic office BP (beta = 0.370, p < 0.001) and diabetes duration (beta = 0.231, p = 0.028) whereas for PWV the following determinants could be identified: age (beta = 0.405, p < 0.001), systolic office BP (beta = 0.421, p < 0.001) and diabetes duration (beta = 0.073, p = 0.038). In addition to the known parameters age, sex and systolic office BP serum LDL-cholesterol, WC and diabetes duration have been identified as determinants of arterial stiffness in patients with T2DM. Treatment of patients in the early stage of T2DM should focus on these clinical parameters to prevent progression of arterial stiffness and as a consequence reduce cardiovascular mortality.Trial registration: The patients included in the analysis participated in one of the following clinical trials NCT02752113 (registered 26.4.2016), NCT02383238 (09.03.2015), NCT02471963 (15.06.2015), NCT01319357 (21.03.2011) ( http://www.clinicaltrials.gov ).

810. Acute rotavirus infection is associated with the induction of circulating memory CD4(+) T cell subsets.

Sci Rep

2023 Jun 2

Malamba-Banda C, Mhango C, Benedicto-Matambo P

811. Urinary concentrations of GHB and its novel amino acid and carnitine conjugates following controlled GHB administration to humans.

Sci Rep

2023 Jun 2

Steuer AE, Bavato F, Schnider LK

812. Sample size calculation for a NanoString GeoMx spatial transcriptomics experiment to study predictors of fibrosis progression in non-alcoholic fatty liver disease.

Sci Rep

2023 Jun 2

Ryaboshapkina M, Azzu V.

813. Analysis of the impact of DGAT1 p.M435L and p.K232A variants on pre-mRNA splicing in a full-length gene assay.

Sci Rep

2023 Jun 2

Gaiani N, Bourgeois-Brunel L, Rocha D

814. Statistical optimization of P(3HB-co-3HHx) copolymers production by Cupriavidus necator PHB(-)4/pBBR_CnPro-phaC(Rp) and its properties characterization.

Sci Rep

2023 Jun 2

Trakunjae C, Boondaeng A, Apiwatanapiwat W

815. Turbulent convection as a significant hidden provider of magnetic helicity in solar eruptions.

Sci Rep

2023 Jun 2

Toriumi S, Hotta H, Kusano K.

816. The evolution of atmospheric particulate matter in an urban landscape since the Industrial Revolution.

Sci Rep

2023 Jun 2

Power AL, Tennant RK, Stewart AG

817. Stage III deficient mismatch repair colon patients get greater benefit from earlier starting oxaliplatin-based chemotherapy regimen.

Sci Rep

2023 Jun 2

Zhan Y(#), Ni K(#), Liu Z(#)

818. First lift-off and flight performance of a tailless flapping-wing aerial robot in high-altitude environments.

Sci Rep

2023 Jun 2

Tsuchiya S, Aono H, Asai K

819. Quality of life and intrinsic capacity in patients with post-acute COVID-19 syndrome is in relation to frailty and resilience phenotypes.

Sci Rep

2023 Jun 2

Guaraldi G, Milic J, Barbieri S

820. Adaptive filter with Riemannian manifold constraint.

Sci Rep

2023 Jun 2

Mejia J, Mederos B, Gordillo N(#)

821. Perceived barriers to maintain physical activity and its association to mental health status of Bangladeshi adults: a quantile regression approach.

Sci Rep

2023 Jun 2

Hasan ABMN, Sharif AB, Jahan I.

Insufficient physical activity and unhealthy lifestyle preferences have been significant concerns for decades. This study aimed to determine the perceived barriers to maintaining physical activity among adults in three major cities of Bangladesh and their association with mental health status. This is a cross-sectional study where 400 participants were selected using a multistage sampling technique. Twenty municipal wards were randomly selected from three cities, followed by a convenient selection of the study participants from each ward. Questionnaires about perceived physical activity barriers were developed based on previously published literature. The DASS-21 scale assessed the mental health status of the study participants. Descriptive statistics were applied to narrate the baseline characteristics of the respondents. The Shapiro-Wilk test was used to check the normality of the perceived physical activity scores. Quantile regression analysis was applied to model the physical activity barrier scores depending on several covariates. Five quantiles were used: the 10th, 25th, 50th, 75th, and 90th. A p-value less than 0.05 was considered significant for hypothesis testing. Among the respondents, 68.50% were male, half of them were married, 68.0% belonged to nuclear families, 48.0% completed graduate level education, 34.25% were service holders, one-third of the respondent's working hours were 6-8 h, and 19.50% belongs to the overweight and obese groups. Poor traffic and construction work near the road (60.30%) was seen as the most significant barrier to physical activity. Over half of the respondents stated that lack of time, facilities, and expenses hinder physical activity. Mental health status reported mild to extremely severe levels of depression (32%), anxiety (47%), and stress (42.50%), respectively. Significant associations between the perceived physical activity scores and gender, family type, occupation, income, BMI, anxiety, and depression were obtained. Ensuring a safe environment, facilitating accessibility and availability of low-cost exercise facilities, improving road and traffic conditions, and providing appropriate mental health counseling may help to mitigate physical activity barriers.

822. Genital tract microbiome dynamics are associated with time of Chlamydia infection in mice.

Sci Rep

2023 Jun 2

Zhao L, Lundy SR, Eko FO

823. Corrosion inhibition properties of schiff base derivative against mild steel in HCl environment complemented with DFT investigations.

Sci Rep

2023 Jun 2

Betti N, Al-Amiery AA, Al-Azzawi WK

824. Extended-spectrum beta-lactamases found in Escherichia coli isolates obtained from blood cultures and corresponding stool specimen.

Sci Rep

2023 Jun 2

Doerr N(#), Dietze N(#), Lippmann N

825. Amplification of typhoon-generated near-inertial internal waves observed near the Tsushima oceanic front in the Sea of Japan.

Sci Rep

2023 Jun 2

Kawaguchi Y, Yabe I, Senjyu T

826. Elevated GRO-α and IL-18 in serum and brain implicate the NLRP3 inflammasome in frontotemporal dementia.

Sci Rep

2023 Jun 2

Lok HC(#), Katzeff JS(#), Hodges JR

827. Syndromes associated with frontotemporal lobar degeneration change response patterns on visual analogue scales.

Sci Rep

2023 Jun 2

Williams RS, Adams NE, Hughes LE

828. Metal artifacts reduction in kV-CT images with polymetallic dentures and complex metals based on MV-CBCT images in radiotherapy.

Sci Rep

2023 Jun 2

Ni X, Shi Z, Song X

829. Impact of TAVR on coronary artery hemodynamics using clinical measurements and image-based patient-specific in silico modeling.

Sci Rep

2023 Jun 2

Garber L(#), Khodaei S(#), Maftoon N

In recent years, transcatheter aortic valve replacement (TAVR) has become the leading method for treating aortic stenosis. While the procedure has improved dramatically in the past decade, there are still uncertainties about the impact of TAVR on coronary blood flow. Recent research has indicated that negative coronary events after TAVR may be partially driven by impaired coronary blood flow dynamics. Furthermore, the current technologies to rapidly obtain non-invasive coronary blood flow data are relatively limited. Herein, we present a lumped parameter computational model to simulate coronary blood flow in the main arteries as well as a series of cardiovascular hemodynamic metrics. The model was designed to only use a few inputs parameters from echocardiography, computed tomography and a sphygmomanometer. The novel computational model was then validated and applied to 19 patients undergoing TAVR to examine the impact of the procedure on coronary blood flow in the left anterior descending (LAD) artery, left circumflex (LCX) artery and right coronary artery (RCA) and various global hemodynamics metrics. Based on our findings, the changes in coronary blood flow after TAVR varied and were subject specific (37% had increased flow in all three coronary arteries, 32% had decreased flow in all coronary arteries, and 31% had both increased and decreased flow in different coronary arteries). Additionally, valvular pressure gradient, left ventricle (LV) workload and maximum LV pressure decreased by 61.5%, 4.5% and 13.0% respectively, while mean arterial pressure and cardiac output increased by 6.9% and 9.9% after TAVR. By applying this proof-of-concept computational model, a series of hemodynamic metrics were generated non-invasively which can help to better understand the individual relationships between TAVR and mean and peak coronary flow rates. In the future, tools such as these may play a vital role by providing clinicians with rapid insight into various cardiac and coronary metrics, rendering the planning for TAVR and other cardiovascular procedures more personalized.

830. Trends in hypertension prevalence, awareness, treatment, and control: an 8-year follow-up study from rural North India.

Sci Rep

2023 Jun 19

Longkumer I, Yadav S, Rajkumari S

831. Host-pathogen interaction unveiled by immune, oxidative stress, and cytokine expression analysis to experimental Saprolegnia parasitica infection in Nile tilapia.

Sci Rep

2023 Jun 19

El Gamal SA(#), Adawy RS, Zaki VH

The present study evaluated the pathogenicity, immunological, and oxidant/antioxidant responses against Saprolegnia parasitica (S. parasitica) infection in Nile tilapia (Oreochromis niloticus). Three groups of Nile tilapia were assigned as the control group (no zoospores exposure). The other two groups were challenged by Saprolegnia zoospores; one was used for sampling, and the other for mortality monitoring. The study lasted 3 weeks and was sampled at three point times at 1, 2, and 3 weeks. Results showed that S. parasitica zoospores were pathogenic to Nile tilapia, causing a cumulative mortality rate of 86.6%. Immunoglobulin M and C- reactive protein (IgM and CRP) levels showed a similar trend being significantly (P < 0.05, P < 0.001) higher in the infected group at weeks 1, 2, and 3, respectively, compared to the control group. Oxidant and antioxidant parameters in gills revealed that Malondialdehyde (MDA) level was significantly higher in the infected group compared to the control group. While catalase, glutathione peroxidase, and superoxide dismutase (CAT, GSH, and SOD) levels were significantly decreased in the infected group compared to the control group. Compared to the control, the tumor necrosis factor-α (TNF-α) gene was firmly upregulated in gill tissue at all-time points, particularly at day 14 post-infection. Meanwhile, Interleukin 1-β (IL-1 β) gene was significantly upregulated only at days 7 and 14 post-infection compared to control. Histopathological examination revealed destructive and degenerative changes in both skin and gills of experimentally infected Nile tilapia. Our findings suggest that Nile tilapia-S. parasitica infection model was successful in better understanding of pathogenicity and host (fish)-pathogen (oomycete) interactions, where the induced oxidative stress and upregulation of particular immune biomarkers in response to S. parasitica infection may play a crucial role in fish defense against oomycetes in fish.

832. Allometry of the quasi-pipe (qPipe) model for estimating tree leaf area and tree leaf mass applied to plant functional types.

Sci Rep

2023 Jun 19

Sumida A, Inagaki Y, Kajimoto T

833. A power allocation strategy for fuel cell ship considering fuel cell performance difference.

Sci Rep

2023 Jun 19

Cao W, Geng P, Xu X

834. The effects of propolis on pro-oxidant-antioxidant balance, glycemic control, and quality of life in chronic kidney disease: a randomized, double-blind, placebo-controlled trial.

Sci Rep

2023 Jun 19

Anvarifard P, Ostadrahimi A, Ardalan M

835. Paraoxonase 2 (PON2) plays a limited role in murine lung tumorigenesis.

Sci Rep

2023 Jun 19

Whitt AG, Neely AM, Sarkar OS

836. A novel defined pyroptosis-related gene signature predicts prognosis and correlates with the tumour immune microenvironment in lung adenocarcinoma.

Sci Rep

2023 Jun 19

Chen Z(#), Ge L(#), Xu S(#)

837. A sub 1 GHz ultra miniaturized folded dipole patch antenna for biomedical applications.

Sci Rep

2023 Jun 19

Chishti AR, Aziz A, Aljaloud K

838. Placebo effects on nausea and motion sickness are resistant to experimentally-induced stress.

Sci Rep

2023 Jun 19

Jacob C, Olliges E, Haile A

839. SnapEnsemFS: a snapshot ensembling-based deep feature selection model for colorectal cancer histological analysis.

Sci Rep

2023 Jun 19

Chattopadhyay S, Singh PK, Ijaz MF

Colorectal cancer is the third most common type of cancer diagnosed annually, and the second leading cause of death due to cancer. Early diagnosis of this ailment is vital for preventing the tumours to spread and plan treatment to possibly eradicate the disease. However, population-wide screening is stunted by the requirement of medical professionals to analyse histological slides manually. Thus, an automated computer-aided detection (CAD) framework based on deep learning is proposed in this research that uses histological slide images for predictions. Ensemble learning is a popular strategy for fusing the salient properties of several models to make the final predictions. However, such frameworks are computationally costly since it requires the training of multiple base learners. Instead, in this study, we adopt a snapshot ensemble method, wherein, instead of the traditional method of fusing decision scores from the snapshots of a Convolutional Neural Network (CNN) model, we extract deep features from the penultimate layer of the CNN model. Since the deep features are extracted from the same CNN model but for different learning environments, there may be redundancy in the feature set. To alleviate this, the features are fed into Particle Swarm Optimization, a popular meta-heuristic, for dimensionality reduction of the feature space and better classification. Upon evaluation on a publicly available colorectal cancer histology dataset using a five-fold cross-validation scheme, the proposed method obtains a highest accuracy of 97.60% and F1-Score of 97.61%, outperforming existing state-of-the-art methods on the same dataset. Further, qualitative investigation of class activation maps provide visual explainability to medical practitioners, as well as justifies the use of the CAD framework in screening of colorectal histology. Our source codes are publicly accessible at: https://github.com/soumitri2001/SnapEnsemFS .

840. Synthesis and antimicrobial activity of new series of thiazoles, pyridines and pyrazoles based on coumarin moiety.

Sci Rep

2023 Jun 19

Sayed MT, Elsharabasy SA, Abdel-Aziem A.

841. Nanosilica treatment enables moisture-resistant hydrophobic arc welding covered electrodes.

Sci Rep

2023 Jun 19

Pasandeh M, Pouranvari M.

842. Meridional binocular rivalry reveals a trace of uncorrected oblique input during development in the adult brain.

Sci Rep

2023 Jun 19

Serero G, Lev M, Polat U.

843. Spatio-temporal evolution of eutrophication and water quality in the Turawa dam reservoir, Poland.

Sci Rep

2023 Jun 19

Buta B, Wiatkowski M, Gruss Ł

844. Phase retrieval from single interferogram without carrier using Lissajous ellipse fitting technology.

Sci Rep

2023 Jun 19

Liu F, Kuang Y, Wu Y

845. Impact of urban spatial structure elements on carbon emissions efficiency in growing megacities: the case of Chengdu.

Sci Rep

2023 Jun 19

Feng T, Zhou B.

846. Effects of high-intensity focused ultrasound combined with levonorgestrel-releasing intrauterine system on patients with adenomyosis.

Sci Rep

2023 Jun 19

Cai Y, Sun Y, Xu F

It is very important to treat adenomyosis which may cause infertility, menorrhagia, and dysmenorrhea for women at the reproductive age. High-intensity focused ultrasound (HIFU) is effective in destroying target tumor tissues without damaging the path of the ultrasound beam and surrounding normal tissues. The levonorgestrel-releasing intrauterine system (LN-IUS) is a medical system which is inserted into the uterine to provide medicinal treatment for temporary control of the symptoms caused by adenomyosis. This study was to investigate the effect of HIFU combined with the LN-IUS on adenomyosis. In the HIFU treatment, the parameters of the ultrasound were transmission frequency 0.8 MHz and input power 50-400 W (350 ± 30), and the temperature in the target tissue under these conditions would reach 60-100 °C (85 °C ± 6.3 °C). Size reduction and blood flow signal decrease were used to assess the effect of combined treatment. In this study, 131 patients with adenomyosis treated with HIFU combined with LN-IUS were retrospectively enrolled. The clinical and follow-up data were analyzed. After treatment, the volume of the uterine lesion was significantly decreased with an effective rate of 72.1%, and the adenomyosis blood flow signals were significantly reduced, with an effective rate of 71.3%. At six months, the menstrual cycle was significantly (P < 0.05) decreased from 31.4 ± 3.5 days before treatment to 28.6 ± 1.9 days, the menstrual period was significantly shortened from 7.9 ± 1.2 days before HIFU to 6.5 ± 1.3 days, and the menstrual volume was significantly (P < 0.05) decreased from 100 to 49% ± 13%. The serum hemoglobin significantly (P < 0.05) increased from 90.8 ± 6.2 g/L before treatment to 121.6 ± 10.8 g/L at six months for patients with anemia. Among seventy-two (92.3%) patients who finished the six-month follow-up, sixty-five (90.3%) patients had the dysmenorrhea completely relieved, and the other seven (9.7%) patients had only slight dysmenorrhea which did not affect their daily life. Adverse events occurred in 24 (18.3%) patients without causing severe consequences, including skin burns in two (1.5%) patients, skin swelling in four (3.1%), mild lower abdominal pain and low fever in 15 (11.5%), and subcutaneous induration in three (2.3%). Six months after treatment, no other serious side effects occurred in any patients with follow-up. In conclusions, the use of high-intensity focused ultrasound combined with the levonorgestrel-releasing intrauterine system for the treatment of adenomyosis is safe and effective even though the long-term effect remains to be confirmed.

847. Distrust as a form of inequality.

Sci Rep

2023 Jun 19

Kubota JT, Venezia SA, Gautam R

848. Thermodynamics, kinetics and isothermal studies of tartrazine adsorption onto microcline/MWCNTs nanocomposite and the regeneration potentials.

Sci Rep

2023 Jun 19

Amaku JF, Taziwa R.

849. Near-surface termination of upward-propagating strike-slip ruptures on the Yangsan Fault, Korea.

Sci Rep

2023 Jun 19

Cheon Y, Kim CM, Choi JH

850. Neural correlates of visual and tactile path integration and their task related modulation.

Sci Rep

2023 Jun 19

Rosenblum L, Kreß A, Arikan BE

851. Phosphogypsum and poultry manure enhance diversity of soil fauna, soil fertility, and barley (Hordeum aestivum L.) grown in calcareous soils.

Sci Rep

2023 Jun 19

Mahmoud E, Ghoneim AM, Seleem M

852. A novel hermit crab optimization algorithm.

Sci Rep

2023 Jun 19

Guo J, Zhou G, Yan K

853. EEG alpha band functional connectivity reveals distinct cortical dynamics for overt and covert emotional face processing.

Sci Rep

2023 Jun 19

Maffei A(#), Coccaro A(#), Jaspers-Fayer F

854. Responses of yield, quality and water use efficiency of potato grown under different drip irrigation and nitrogen levels.

Sci Rep

2023 Jun 19

Akkamis M, Caliskan S.

855. Anomalous excess noise behavior in thick Al(0.85)Ga(0.15)As(0.56)Sb(0.44) avalanche photodiodes.

Sci Rep

2023 Jun 19

Lewis HIJ(#), Jin X(#), Guo B

856. Early porosity generation in organic-sulfur-rich mudstones.

Sci Rep

2023 Jun 19

Knapp LJ, Ardakani OH, Reyes J

857. Impact of heat stress, water stress, and their combined effects on the metabolism and transcriptome of grape berries.

Sci Rep

2023 Jun 19

Hewitt S, Hernández-Montes E, Dhingra A

858. Electrospun cellulose acetate/activated carbon composite modified by EDTA (rC/AC-EDTA) for efficient methylene blue dye removal.

Sci Rep

2023 Jun 19

Elmaghraby NA, Omer AM, Kenawy ER

859. Serological response following COVID-19 vaccines in patients living with HIV: a dose-response meta-analysis.

Sci Rep

2023 Jun 19

Zhou Q, Zeng F, Meng Y

860. Taming Fabry-Pérot resonances in a dual-metasurface multiband antenna with beam steering in one of the bands.

Sci Rep

2023 Jun 19

Gonçalves Licursi de Mello R, Lepage AC, Begaud X.

861. Convective heat and mass transfer rate on 3D Williamson nanofluid flow via linear stretching sheet with thermal radiation and heat absorption.

Sci Rep

2023 Jun 19

Jagadeesh S, Chenna Krishna Reddy M, Tarakaramu N

862. Machine learning algorithms for predicting days of high incidence for out-of-hospital cardiac arrest.

Sci Rep

2023 Jun 19

Shimada-Sammori K, Shimada T, Miura RE

863. Reappraising the evolutionary history of the largest known gecko, the presumably extinct Hoplodactylus delcourti, via high-throughput sequencing of archival DNA.

Sci Rep

2023 Jun 19

Heinicke MP, Nielsen SV, Bauer AM

864. Process optimization in poultry feed mill.

Sci Rep

2023 Jun 19

Amin SAS, Sobhi N.

865. Neural bases of reward anticipation in healthy individuals with low, mid, and high levels of schizotypy.

Sci Rep

2023 Jun 19

Carruzzo F, Giarratana AO, Del Puppo L

866. Structural connectome alterations in anxious dogs: a DTI-based study.

Sci Rep

2023 Jun 19

Chen Q(#), Xu Y(#), Christiaen E

867. Effect of solar proton events on test mass for gravitational wave detection in the 24th solar cycle.

Sci Rep

2023 Jun 19

Han R, Cai M, Yang T

868. First-principles study on the electronic and optical properties of AlSb monolayer.

Sci Rep

2023 Jun 19

Mohebpour MA, Tagani MB.

869. HOXA3 accelerates wound healing in diabetic and aged non-diabetic mammals.

Sci Rep

2023 Jun 19

Parella K, Moody K, Wortel D

870. Comprehensive power quality performance assessment for electrical system of a nuclear research reactor.

Sci Rep

2023 Jun 19

Elsotohy AM, Soliman AMA, Adail AS

Studying the power quality (PQ) is an essential issue to ensure the safe and accurate operation of sensitive equipment particularly for nuclear installations. Assessment of PQ involves collecting and analysing data resources and then evaluating it with reference to PQ standards. There are many alternatives for PQ and it is difficult to make an appropriate selection among them in the existence of their multiple criteria which are usually conflicted. So this selection subject can be classified as a Multi Criteria Decision Making (MCDM) problem. To do so, a reliable and scientific method for studying and evaluating the overall system PQ is required. This study aims to assess performance of PQ for the electrical power system at a Nuclear Research Reactor (NRR) during a certain period using multiple measures for the most decisive PQ phenomena. It focuses on a number of the most important PQ phenomena namely frequency fluctuation (deviation), unbalances of current and voltage, current and voltage harmonic distortion, flicker and power factor. After combining all results into six samples (alternatives), the criteria weights are determined based on an objective method for weighting which is called CRITIC method. Then, the alternatives are ranked using compromise MCDM method-VIKOR method. The obtained results are analyzed and discussed to evaluate performance of NRR electrical system from the PQ view. It showed that the compromise solution that obtained by CRITIC-VIKOR can be a guide to facilitate the PQ evaluation of nuclear installation electrical system. Also, it can empower the operators with the benefits of benchmarking and monitoring a single index instead of several indices. Moreover, it is very useful for helping stakeholders to understand how the PQ performance changes under a certain operating condition of the facility. Finally, it is can be considered as a good model to weight each PQ phenomena and identify the time intervals for best and worst total PQ in NRR.

871. Second harmonic generation on crystalline organic nanoclusters under extreme nanoconfinement in functionalized silica-benzil composites.

Sci Rep

2023 Jun 19

El Karout H, Shchur Y, Andrushchak A

We demonstrate a series of organic-inorganic nanocomposite materials combining the mesoporous silica (PS) and benzil (BZL) nanocrystals embedded into its nanochannels (6.0-13.0 nm in diameter) by capillary crystallization. One aims to design novel, efficient nonlinear optical composite materials in which inactive amorphous host PS-matrix provides a tubular scaffold structure, whereas nonlinear optical functionality results from specific properties of the deposited guest BZL-nanocrystals. A considerable contraction of the BZL melt during its crystallization inside the silica nanochannels results in a formation of the texture consisting of (221)- and (003)-oriented BZL nanoclusters (22 nm in length), separated by voids. Specificity of the textural morphology similarly to the spatial confinement significantly influences the nonlinear optical features of composite PS:BZL materials being explored in the second harmonic generation (SHG) experiment. The light polarization anisotropy of the SHG response appears to be considerably reduced at channel diameters larger than 7 nm apparently due to the multiple scattering and depolarization of the light on randomly distributed and crystallographically oriented BZL-nanoclusters. The normalized SHG response decreases nonlinearly by more than one order of magnitude as the channel diameter decreases from 13.0 to 6.0 nm and vanishes when spatial cylindrical confinement approaches the sizes of a few molecular layers suggesting that the embedded BZL clusters indeed are not uniformly crystalline but are characterized by more complex morphology consisting of a disordered SHG-inactive amorphous shell, covering the channel wall, and SHG-active crystalline core. Understanding and controlling of the textural morphology in inorganic-organic nanocrystalline composites as well as its relationships with nonlinear optical properties can lead to the development of novel efficient nonlinear optical materials for the light energy conversion with prospective optoelectronic and photonic applications.

872. A new method of alternating shooting of two different seismic sources for deep geophysical surveys.

Sci Rep

2023 Jun 19

Liu C, Fu J, Hua Q

873. Rickettsia species in Dermacentor reticulatus ticks feeding on human skin and clinical manifestations of tick-borne infections after tick bite.

Sci Rep

2023 Jun 19

Koczwarska J, Pawełczyk A, Dunaj-Małyszko J

874. Identification of macrophage-related genes in sepsis-induced ARDS using bioinformatics and machine learning.

Sci Rep

2023 Jun 19

Li Q(#), Zheng H(#), Chen B.

875. Fundus autofluorescence imaging using red excitation light.

Sci Rep

2023 Jun 19

Birtel J(#), Bauer T(#), Pauleikhoff L

876. Inflammatory cytokines and chemokines in obese adolescents with antibody against to adenovirus 36.

Sci Rep

2023 Jun 19

Sanches MD, Goldberg TBL, Rizzo ADCB

877. Recovery of fuel from real waste oily sludge via a new eco-friendly surfactant material used in a digital baffle batch extraction unit.

Sci Rep

2023 Jun 19

Humadi JI, Jafar SA, Ali NS

878. High efficiency carbon nanotubes-based single-atom catalysts for nitrogen reduction.

Sci Rep

2023 Jun 19

Liu W(#), Guo K(#), Xie Y

879. Analysis of the surgical approach in prostate cancer staging: results from the surveillance, epidemiology and end results program.

Sci Rep

2023 Jun 19

da Luz FAC, Nascimento CP, da Costa Marinho E

Surgery is not used as a criterion for staging prostate cancer, although there is evidence that the number of analyzed and affected lymph nodes have prognosis value. The aim of this study was to determine whether there are significant differences in staging criteria in patients who underwent prostatectomy compared to those who did not, and whether the number of affected and analyzed lymph nodes (LN) plays a prognostic role. In this retrospective study, a test cohort consisting of 404,210 newly diagnosed men with prostate cancer, between 2004 and 2010, was obtained from the 17 registries (Nov 2021 submission); a validation consisting of 147,719 newly diagnosed men with prostate cancer between 2004 and 2019 was obtained from the 8 registries (Nov 2021 submission). Prostate cancer-specific survival was analyzed by Kaplan-Meier curves, survival tables and Cox regression; overall survival was analyzed only to compare Harrell's C-index between different staging criteria. In initial analyses, it was observed that the prognostic value of lymph node metastasis changes according to the type of staging (clinical or pathological), which is linked to the surgical approach (prostatectomy). Compared with T4/N0/M0 patients, which are also classified as stage IVA, N1/M0 patients had a shorter [adjusted HR: 1.767 (1429-2184), p < 0.0005] and a longer [adjusted HR: 0.832 (0.740-0.935), p = 0.002] specific survival when submitted to prostatectomy or not, respectively. Analyzing separately the patients who were submitted to prostatectomy and those who were not, it was possible to obtain new LN metastasis classifications (N1: 1 + LN; N2: 2 + LNs; N3: > 2 + LNs). This new (pathological) classification of N allowed the reclassification of patients based on T and Gleason grade groups, mainly those with T3 and T4 disease. In the validation group, this new staging criterion was proven to be superior [specific survival C-index: 0.908 (0.906-0.911); overall survival C-index: 0.788 (0.786-0.791)] compared to that currently used by the AJCC [8th edition; specific survival C-index: 0.892 (0.889-0.895); overall survival C-index: 0.744 (0.741-0.747)]. In addition, an adequate number of dissected lymph nodes results in a 39% reduction in death risk [adjusted HR: 0.610 (0.498-0.747), p < 0.0005]. As main conclusion, the surgery has a major impact on prostate cancer staging, mainly modifying the effect of N on survival, and enabling the stratification of pathological N according to the number of affected LN. Such a factor, when considered as staging criteria, improves the prognosis classification.

880. Characteristics of persistent arthritis with refractory Kawasaki disease: a single-center retrospective study.

Sci Rep

2023 Jun 19

Hattori S, Nozawa T, Nishimura K

881. An efficient single shot detector with weight-based feature fusion for small object detection.

Sci Rep

2023 Jun 19

Li M, Pi D, Qin S.

882. Chemically engineered unzipped multiwalled carbon nanotube and rGO nanohybrid for ultrasensitive picloram detection in rice water and soil samples.

Sci Rep

2023 Jun 19

Dkhar DS, Kumari R, Chandra P.

883. Comorbidity genetic risk and pathways impact SARS-CoV-2 infection outcomes.

Sci Rep

2023 Jun 19

Jaros RK, Fadason T, Cameron-Smith D

884. Middle-shallow feature aggregation in multimodality for face anti-spoofing.

Sci Rep

2023 Jun 19

Li C, Li Z, Sun J

885. Infants' interoception is associated with eye contact in dyadic social interactions.

Sci Rep

2023 Jun 19

Imafuku M, Yoshimoto H, Hiraki K.

886. A comparison of machine learning methods to classify radioactive elements using prompt-gamma-ray neutron activation data.

Sci Rep

2023 Jun 19

Mathew J, Kshirsagar R, Abidin DZ

887. Malaria surveillance, outbreak investigation, response and its determinant factors in Waghemra Zone, Northeast Ethiopia: unmatched case-control study.

Sci Rep

2023 Jun 19

Debash H, Nigatie M, Bisetegn H

Malaria is a major global public health concern, with around half of the world's population at risk of infection. It is one of the most common epidemic-prone diseases, resulting in on-going epidemics and significant public health problems. On September 12, 2022, Waghemra Zone malaria monitoring data revealed that the district was suffering an unusually high number of malaria cases. Therefore, the aim of this study was to assess the occurrence of malaria outbreaks and investigate contracting factors in Waghemra Zone, Northeast Ethiopia. A community-based case-control study with a 1:1 ratio was employed at Waghemra Zone from September 14 to November 27, 2022. A total of 260 individuals (130 cases and 130 controls) were included in the study. A structured questionnaire was used to collect the data. Malaria cases were confirmed by either microscopy or malaria rapid diagnostic tests. The magnitude of the outbreak was described by place, person, and time. A multivariable logistic regression analysis was conducted to identify malaria risk factors. A total of 13,136 confirmed cases of malaria were detected in the Waghemra zone, with an overall attack rate of 26.5 per 1000 and slide positivity rate was 43.0%. The predominant species was Plasmodium falciparum accounting for 66.1%. Children under five years old (AOR = 5.1; 95% CI 2.6-23.0), the presence of artificial water-holding bodies (AOR: 2.7; 95% CI 1.340-5.420), intermittent rivers closer to the living house (AOR = 4.9; 95% CI 2.51-9.62), sleeping outside a home (AOR = 4.9; 95% CI 2.51-9.62), and a lack of knowledge about malaria transmission and prevention (AOR: 9.7; 95% CI 4.459-20.930) were factors associated with malaria contraction. The overall attack rate for malaria during this outbreak was high. Children less than five years, the presence of mosquito breeding sites, staying outdoors overnight, and a lack of knowledge on malaria transmission and prevention were predictors of malaria. Early management of local vector breeding places, as well as adequate health education on malaria transmission and prevention methods, should be provided to the community to prevent such outbreaks in the future.

888. Identification of novel putative alleles related to important agronomic traits of wheat using robust strategies in GWAS.

Sci Rep

2023 Jun 19

Abdi H, Alipour H, Bernousi I

Principal component analysis (PCA) is widely used in various genetics studies. In this study, the role of classical PCA (cPCA) and robust PCA (rPCA) was evaluated explicitly in genome-wide association studies (GWAS). We evaluated 294 wheat genotypes under well-watered and rain-fed, focusing on spike traits. First, we showed that some phenotypic and genotypic observations could be outliers based on cPCA and different rPCA algorithms (Proj, Grid, Hubert, and Locantore). Hubert's method provided a better approach to identifying outliers, which helped to understand the nature of these samples. These outliers led to the deviation of the heritability of traits from the actual value. Then, we performed GWAS with 36,000 single nucleotide polymorphisms (SNPs) based on the traditional approach and two robust strategies. In the conventional approach and using the first three components of cPCA as population structure, 184 and 139 marker-trait associations (MTAs) were identified for five traits in well-watered and rain-fed environments, respectively. In the first robust strategy and when rPCA was used as population structure in GWAS, we observed that the Hubert and Grid methods identified new MTAs, especially for yield and spike weight on chromosomes 7A and 6B. In the second strategy, we followed the classical and robust principal component-based GWAS, where the first two PCs obtained from phenotypic variables were used instead of traits. In the recent strategy, despite the similarity between the methods, some new MTAs were identified that can be considered pleiotropic. Hubert's method provided a better linear combination of traits because it had the most MTAs in common with the traditional approach. Newly identified SNPs, including rs19833 (5B) and rs48316 (2B), were annotated with important genes with vital biological processes and molecular functions. The approaches presented in this study can reduce the misleading GWAS results caused by the adverse effect of outlier observations.

889. Probability density function for random photon steps in a binary (isotropic-Poisson) statistical mixture.

Sci Rep

2023 Jun 19

Binzoni T, Mazzolo A.

890. Conditions for the origin of homochirality in primordial catalytic reaction networks.

Sci Rep

2023 Jun 19

Gagnon JS, Hochberg D.

891. A closer association between blood urea nitrogen and the probability of diabetic retinopathy in patients with shorter type 2 diabetes duration.

Sci Rep

2023 Jun 19

Zhong JB(#), Yao YF(#), Zeng GQ

892. The chromosome-scale genome assembly of cluster bean provides molecular insight into edible gum (galactomannan) biosynthesis family genes.

Sci Rep

2023 Jun 19

Gaikwad K, Ramakrishna G, Srivastava H

893. Effects of 90- and 30-min naps or a 120-min nap on alertness and performance: reanalysis of an existing pilot study.

Sci Rep

2023 Jun 18

Oriyama S.

894. Quantitative evaluation of blinking in blepharospasm using electrooculogram-integrated smart eyeglasses.

Sci Rep

2023 Jun 18

Yoshimura A, Hosotani Y, Kimura A

895. Preceding and trailing role-taking in dyad synchronization using finger tapping.

Sci Rep

2023 Jun 18

Kimura K, Tanaka Y, Ogata T

896. Delineation of suitable sites for groundwater recharge based on groundwater potential with RS, GIS, and AHP approach for Mand catchment of Mahanadi Basin.

Sci Rep

2023 Jun 18

Baghel S, Tripathi MP, Khalkho D

Groundwater management requires a systematic approach since it is crucial to the long-term viability of livelihoods and regional economies all over the world. There is insufficient groundwater management and difficulties in storage plans as a result of increased population, fast urbanisation, and climate change, as well as unpredictability in rainfall frequency and intensity. Groundwater exploration using remote sensing (RS) data and geographic information system (GIS) has become a breakthrough in groundwater research, assisting in the assessment, monitoring, and conservation of groundwater resources. The study region is the Mand catchment of the Mahanadi basin, covering 5332.07 km2 and is located between 21°42'15.525″N and 23°4'19.746″N latitude and 82°50'54.503″E and 83°36'1.295″E longitude in Chhattisgarh, India. The research comprises the generation of thematic maps, delineation of groundwater potential zones and the recommendation of structures for efficiently and successfully recharging groundwater utilising RS and GIS. Groundwater Potential Zones (GPZs) were identified with nine thematic layers using RS, GIS, and the Multi-Criteria Decision Analysis (MCDA) method. Satty's Analytic Hierarchy Process (AHP) was used to rank the nine parameters that were chosen. The generated GPZs map indicated regions with very low, low to medium, medium to high, and very high groundwater potential encompassing 962.44 km2, 2019.92 km2, 969.19 km2, and 1380.42 km2 of the study region, respectively. The GPZs map was found to be very accurate when compared with the groundwater fluctuation map, and it is used to manage groundwater resources in the Mand catchment. The runoff of the study area can be accommodated by the computing subsurface storage capacity, which will raise groundwater levels in the low and low to medium GPZs. According to the study results, various groundwater recharge structures such as farm ponds, check dams and percolation tanks were suggested in appropriate locations of the Mand catchment to boost groundwater conditions and meet the shortage of water resources in agriculture and domestic use. This study demonstrates that the integration of GIS can provide an efficient and effective platform for convergent analysis of various data sets for groundwater management and planning.

897. Fc-competent multispecific PDL-1/TIGIT/LAG-3 antibodies potentiate superior anti-tumor T cell response.

Sci Rep

2023 Jun 18

Yang R, Huang S, Huang C

898. Study on the infrared dynamic evolution characteristics of different joint inclination phyllite under uniaxial compression.

Sci Rep

2023 Jun 18

Chengyu X, Weihang L, Ziwei C

899. Predicting outcomes of acute kidney injury in critically ill patients using machine learning.

Sci Rep

2023 Jun 18

Nateghi Haredasht F, Viaene L, Pottel H

900. A hybrid multifunctional physicochemical sensor suite for continuous monitoring of crop health.

Sci Rep

2023 Jun 17

Hossain NI, Tabassum S.

901. Single-cell transcriptomic profiling of microvascular endothelial cell heterogeneity in congenital diaphragmatic hernia.

Sci Rep

2023 Jun 17

Robertson JO, Bazeley P, Erzurum SC

902. Evolving relationship of Nares Strait ice arches on sea ice along the Strait and the North Water, the Arctic's most productive polynya.

Sci Rep

2023 Jun 17

Moore GWK, Howell SEL, Brady M.

903. Carbon stocks of particle board and fiberboard in Japan.

Sci Rep

2023 Jun 17

Kayo C, Sanjo K, Sato I

904. The QuantuMDx Q-POC SARS-CoV-2 RT-PCR assay for rapid detection of COVID-19 at point-of-care: preliminary evaluation of a novel technology.

Sci Rep

2023 Jun 17

Caffry J(#), Selby M(#), Barr K

905. Research on psychological attributions and intervention strategies of new energy hybrid vehicle purchase behavior.

Sci Rep

2023 Jun 17

Guo Q, You W.

906. Cannabis sativa-based oils against aluminum-induced neurotoxicity.

Sci Rep

2023 Jun 17

Alves C, Tamagno WA, Vanin AP

907. Red narrow-linewidth lasing and frequency comb from gain-switched self-injection-locked Fabry-Pérot laser diode.

Sci Rep

2023 Jun 17

Shitikov AE, Galiev RR, Min'kov KN

908. Effects of high- and low-yield moso bamboo (Phyllostachys edulis) forests on bacterial community structure.

Sci Rep

2023 Jun 17

Liu F, Yuan ZS, Zeng ZH

909. Optimal quantum network decongestion strategies.

Sci Rep

2023 Jun 17

Perju Verzotti L, Ciobanu BC, Popescu PG.

910. Tracking volcanic explosions using Shannon entropy at Volcán de Colima.

Sci Rep

2023 Jun 17

Rey-Devesa P, Prudencio J, Benítez C

911. Taxonomic and functional diversity of land snails reflects habitat complexity in riparian forests.

Sci Rep

2023 Jun 17

Gheoca V, Benedek AM, Schneider E.

912. Complete genomes and comparative analyses of Streptomyces phages that influence secondary metabolism and sporulation.

Sci Rep

2023 Jun 17

Kronheim S, Solomon E, Ho L

913. Increased red blood cell deformation in children and adolescents after SARS-CoV-2 infection.

Sci Rep

2023 Jun 17

Eder J(#), Schumm L(#), Armann JP

914. Evolution of cooperation in multiplex networks through asymmetry between interaction and replacement.

Sci Rep

2023 Jun 17

Inaba M, Akiyama E.

915. Modified stochastic medium prediction model for the deformation response of concealed underground stations under existing pipelines.

Sci Rep

2023 Jun 17

Zhang J, Pan T, Ma K

916. Revisiting and updating molecular epidemiology of α-thalassemia mutations in Thailand using MLPA and new multiplex gap-PCR for nine α-thalassemia deletion.

Sci Rep

2023 Jun 17

Jomoui W(#), Panyasai S(#), Sripornsawan P

917. Screening macroalgae for mitigation of enteric methane in vitro.

Sci Rep

2023 Jun 17

Wasson DE, Stefenoni H, Cueva SF

918. Spectroscopic investigations to reveal synergy between polystyrene waste and paraffin wax in super-hydrophobic sand.

Sci Rep

2023 Jun 17

Al-Mokhalelati K, Karabet F, Allaf AW

919. Emergence of a novel sublineage, MYMBD21 under SA-2018 lineage of Foot-and-Mouth Disease Virus serotype O in Bangladesh.

Sci Rep

2023 Jun 17

Hossain KA(#), Anjume H(#), Alam KMM

920. Variational quantum non-orthogonal optimization.

Sci Rep

2023 Jun 17

Bermejo P, Orús R.

921. Associations between intrinsic capacity, functional difficulty, and fall outcomes among older adults in India.

Sci Rep

2023 Jun 17

Muneera K, Muhammad T, Pai M

The construct of intrinsic capacity (IC) in the context of integrated care for older adults emphasizes functional assessment from a holistic perspective. It provides reliable and comparable insights on subsequent functioning and disability. Given the paucity of research on IC and health outcomes in low- and middle-income countries (LMICs), the present study examined the association of IC with geriatric conditions of functional limitations and multiple fall outcomes among older adults in India. The data used for analysis come from the first wave of the Longitudinal Aging Study in India (LASI), 2017-2018. The final sample size contains 24,136 older adults (11,871 males and 12,265 females) age 60 years or above. Multivariable binary logistic regression is employed to examine the association of IC and other explanatory factors with outcome variables of difficulty in activities of daily living (ADL) and instrumental activities of daily living (IADL), falls, fall injury, and multiple falls. Of the total sample, 24.56% of older adults were observed to be in the high IC category. The prevalence of ADL difficulty, IADL difficulty, falls, multiple falls and fall-related injury is estimated to be 19.89%, 45.00%, 12.36%, 5.49% and 5.57%, respectively. Older adults who reported high IC had a significantly lower prevalence of ADL difficulty (12.26% vs 22.38%) and IADL difficulty (31.13% vs 49.52%) than those who reported low IC. Similarly, a lower prevalence of falls (9.42% vs 13.34%), fall-related injury (4.10% vs 6.06%) and multiple falls (3.46% vs 6.16%) were reported among those who had high IC. After adjusting for a large number of confounders such as age, sex, health-related attributes and lifestyle behaviors, older adults with high IC had significantly lower odds of ADL difficulty [aOR: 0.63, CI: 0.52-0.76], IADL difficulty [aOR: 0.71, CI: 0.60-0.83], falls [aOR: 0.80, CI: 0.67-0.96], multiple falls [aOR: 0.73, CI: 0.58-0.96] and fall-related injury [aOR: 0.78, CI: 0.61-0.99]. That a high IC was independently associated with a lower risk of functional difficulty and fall outcomes in later life is of enormous value in predicting subsequent functional care needs. More specifically, the findings here imply that because regular IC monitoring can predict poor health outcomes in older adults, improvements in IC should be prioritized while formulating disability and fall prevention strategies.

922. Interplay between uncertainty intolerance, emotion regulation, cognitive flexibility, and psychopathology during the COVID-19 pandemic: a multi-wave study.

Sci Rep

2023 Jun 17

Godara M, Everaert J(#), Sanchez-Lopez A(#)

923. Research on the establishment of NDVI long-term data set based on a novel method.

Sci Rep

2023 Jun 17

Fan D.

924. Diagnostic performance of calf circumference, SARC-F, and SARC-CalF for possible sarcopenia screening in Indonesia.

Sci Rep

2023 Jun 17

Kandinata SG, Widajanti N, Ichwani J

925. A novel combined intelligent algorithm prediction model for the tunnel surface settlement.

Sci Rep

2023 Jun 17

Wang Y, Dai F, Jia R

926. Ready vascular permeability of a near-infrared fluorescent agent ASP5354 for intraoperative ureteral identification enables imaging of carcinoma tissues.

Sci Rep

2023 Jun 17

Teranishi K.

927. Tozorakimab (MEDI3506): an anti-IL-33 antibody that inhibits IL-33 signalling via ST2 and RAGE/EGFR to reduce inflammation and epithelial dysfunction.

Sci Rep

2023 Jun 17

England E(#), Rees DG(#), Scott IC(#)

928. Inflammatory-like status and acute stress response in horses after road transport.

Sci Rep

2023 Jun 17

Arfuso F, Rizzo M, Giannetto C

929. Characterization of bacteriophage vB_KleM_KB2 possessing high control ability to pathogenic Klebsiella pneumoniae.

Sci Rep

2023 Jun 17

Peng Q, Ma Z, Han Q

930. Many-body correlations in one-dimensional optical lattices with alkaline-earth(-like) atoms.

Sci Rep

2023 Jun 17

Bilokon V, Bilokon E, Bañuls MC

931. Machine-learning-based diagnosis of thyroid fine-needle aspiration biopsy synergistically by Papanicolaou staining and refractive index distribution.

Sci Rep

2023 Jun 17

Lee YK(#), Ryu D(#), Kim S(#)

932. Entropy optimization and response surface methodology of blood hybrid nanofluid flow through composite stenosis artery with magnetized nanoparticles (Au-Ta) for drug delivery application.

Sci Rep

2023 Jun 17

Algehyne EA, Ahammad NA, Elnair ME

Entropy creation by a blood-hybrid nanofluid flow with gold-tantalum nanoparticles in a tilted cylindrical artery with composite stenosis under the influence of Joule heating, body acceleration, and thermal radiation is the focus of this research. Using the Sisko fluid model, the non-Newtonian behaviour of blood is investigated. The finite difference (FD) approach is used to solve the equations of motion and entropy for a system subject to certain constraints. The optimal heat transfer rate with respect to radiation, Hartmann number, and nanoparticle volume fraction is calculated using a response surface technique and sensitivity analysis. The impacts of significant parameters such as Hartmann number, angle parameter, nanoparticle volume fraction, body acceleration amplitude, radiation, and Reynolds number on the velocity, temperature, entropy generation, flow rate, shear stress of wall, and heat transfer rate are exhibited via the graphs and tables. Present results disclose that the flow rate profile increase by improving the Womersley number and the opposite nature is noticed in nanoparticle volume fraction. The total entropy generation reduces by improving radiation. The Hartmann number expose a positive sensitivity for all level of nanoparticle volume fraction. The sensitivity analysis revealed that the radiation and nanoparticle volume fraction showed a negative sensitivity for all magnetic field levels. It is seen that the presence of hybrid nanoparticles in the bloodstream leads to a more substantial reduction in the axial velocity of blood compared to Sisko blood. An increase in the volume fraction results in a noticeable decrease in the volumetric flow rate in the axial direction, while higher values of infinite shear rate viscosity lead to a significant reduction in the magnitude of the blood flow pattern. The blood temperature exhibits a linear increase with respect to the volume fraction of hybrid nanoparticles. Specifically, utilizing a hybrid nanofluid with a volume fraction of 3% leads to a 2.01316% higher temperature compared to the base fluid (blood). Similarly, a 5% volume fraction corresponds to a temperature increase of 3.45093%.

933. Association between interatrial septum adiposity and atrial fibrillation: transesophageal echocardiography imaging and autopsy study.

Sci Rep

2023 Jun 17

Miyoshi M, Abe I, Kodama N

Recent clinical evidence has suggested that interatrial septal (IAS) adiposity contributes to atrial fibrillation (AF). The present study aimed to confirm the usefulness of transesophageal echocardiography (TEE) to estimate IAS adiposity in patients with AF. The histological IAS analysis based on autopsy samples sought to clarify characteristics that underlie the contribution of IAS adiposity to AF. The imaging study analyzed the TEE results in patients with AF (n = 184) in comparison with transthoracic echocardiography (TTE) and computed tomography (CT) results. The autopsy study histologically analyzed IAS in subjects with (n = 5) and without (n = 5) history of AF. In the imaging study, the ratio of interatrial septum adipose tissue (IAS-AT) volume per epicardial adipose tissue (EpAT) volume was greater in patients with persistent AF compared (PerAF) to those with paroxysmal AF (PAF). Multivariable analysis revealed that both TEE-assessed IAS thickness and TTE-assessed left atrial dimension were predicted by CT-assessed IAS-AT volume. In the autopsy study, the histologically-assessed IAS section thickness was greater in the AF group than that in the non-AF group and was positively correlated with the IAS-AT area percentage. In addition, the size of adipocytes in IAS-AT was smaller, compared to EpAT and subcutaneous adipose tissue (SAT). IAS-AT infiltrated into the IAS myocardium, as if adipose tissue split the myocardium (designated as myocardial splitting by IAS-AT). The number of island-like myocardium pieces as a result of myocardial splitting by IAS-AT was greater in the AF group than in the non-AF group and was positively correlated with the IAS-AT area percentage. The present imaging study confirmed the usefulness of TEE to estimate IAS adiposity in patients with AF without radiation exposure. The autopsy study suggested that the myocardial splitting by IAS-AT may contribute to atrial cardiomyopathy leading to AF.

934. Intramedullary bone tissue reaction of ion-releasing resin-modified glass-ionomer restoration versus two calcium silicate-based cements: an animal study.

Sci Rep

2023 Jun 17

ElReash AA, Grawish M, Abdo W

This comparative study was conducted to assess the intramedullary bone tissue reaction of an ion-releasing resin modified glass-ionomer cement with claimed bioactivity (ACTIVA bioactive resin) restorative material versus Mineral Trioxide Aggregate High Plasticity (MTA HP) and bioceramic putty iRoot BP Plus. Fifty-six adult male Wistar rats were assigned into 4 equal groups (14 rats each). A surgical intramedullary bi-lateral tibial bone defects were performed in rats of the control group I (GI) and left without any treatment to be considered as controls (n = 28). The rats of groups II, III and IV were handled as group I except that the tibial bone defects were filled with ACTIVA, MTA HP and iRoot BP, respectively. In all groups, rats were euthanized after one month and specimens were processed to histological investigation, SEM examination and EDX elemental analysis. In addition, semi-quantitative histomorphometric scoring system was conducted for the following parameters; new bone formation, inflammatory response, angiogenesis, granulation tissue, osteoblasts and osteoclasts. The clinical follow-up outcome of this study revealed the recovery of rats after 4 days post-surgical procedure. It was observed that the animal subjects returned to their routine activities, e.g., walking, grooming and eating. The rats showed normal chewing efficiency without any weight loss or postoperative complications. Histologically, the control group sections showed scanty, very thin, new bone trabeculae of immature woven type located mostly at the peripheral part of the tibial bone defects. These defects exhibited greater amount of thick bands of typically organized granulation tissue with central and peripheral orientation. Meanwhile, bone defects of ACTIVA group showed an empty space surrounded by thick, newly formed, immature woven bone trabeculae. Moreover, bone defects of MTA HP group were partially filled with thick newly formed woven bone trabeculae with wide marrow spaces presented centrally and at the periphery with little amount of mature granulation tissue at the central part. The iRoot BP Plus group section exhibited an observable woven bone formation of normal trabecular structures with narrow marrow spaces presented centrally and at the periphery showed lesser amount of well-organized/mature granulation tissue formation. Kruskal Wallis test revealed total significant differences between the control, ACTIVA, MTAHP and iRoot BP Plus groups (p < 0.05). Meanwhile, Mann-Whitney U test showed significant difference between control and ACTIVA groups, Control and MTA HP groups, control and iRoot BP Plus groups. ACTIVA and MTA HP groups, ACTIVA and iRoot BP Plus (p ˂ 0.05) with no significant difference between MTA HP and iRoot BP Plus (p > 0.05). The elemental analysis outcome showed that the lesions of the control group specimens were filled with recently created trabecular bone with limited marrow spaces. EDX tests (Ca and P analysis) indicated a lower degree of mineralization. Lower amounts of Ca and P was expressed in the mapping analysis compared with other test groups. Calcium silicate-based cements induce more bone formation when compared to an ion-releasing resin modified glass-ionomer restoration with claimed bioactivity. Moreover, the bio-inductive properties of the three tested materials are likely the same. Clinical significance: bioactive resin composite can be used as a retrograde filling.

935. miRNAs signature as potential biomarkers for cervical precancerous lesions in human papillomavirus positive women.

Sci Rep

2023 Jun 17

González-Ramírez MI, Cardona YT, Agudelo MC

936. Ramularia leaf spot: PCR-based methods reveal widespread distribution of Ramulariopsis pseudoglycines and limited presence of R. gossypii in Brazil.

Sci Rep

2023 Jun 17

da Silva AS(#), Rennó MHL(#), Quitania ACR

937. Stability analysis and control technology of the sump-surrounding rock under a 1200-m-deep goaf: a case study.

Sci Rep

2023 Jun 17

Xie S, Li H, Chen D

938. Optically induced electrothermal microfluidic tweezers in bio-relevant media.

Sci Rep

2023 Jun 17

Gupta K, Moon HR, Chen Z

939. Proton and alpha radiation-induced mutational profiles in human cells.

Sci Rep

2023 Jun 16

Delhomme TM(#), Munteanu M(#), Buonanno M

940. The environmental controls on efficiency of enhanced rock weathering in soils.

Sci Rep

2023 Jun 16

Deng H, Sonnenthal E, Arora B

941. Regulation of microRNA expression by the adaptor protein GRB2.

Sci Rep

2023 Jun 16

Stainthorp AK, Lin CC, Wang D

942. Using DUCK-Net for polyp image segmentation.

Sci Rep

2023 Jun 16

Dumitru RG, Peteleaza D, Craciun C.

943. The prevalence of masked hypertension in patients with lone atrial fibrillation: a cross sectional analytical study.

Sci Rep

2023 Jun 16

Ayalon-Dangur I, Ofer-Shiber S, Shochat T

944. Deep learning for diffusion in porous media.

Sci Rep

2023 Jun 16

Graczyk KM, Strzelczyk D, Matyka M.

945. An analysis of the climate change effects on pesticide vapor drift from ground-based pesticide applications to cotton.

Sci Rep

2023 Jun 16

Kannan N.

Vapor drift of applied pesticides is an increasing concern. Among the major crops cultivated in the Lower Mississippi Delta (LMD), cotton receives most of the pesticides. An investigation was carried out to determine the likely changes in pesticide vapor drift (PVD) as a result of climate change that occurred during the cotton growing season in LMD. This will help to better understand the consequences and prepare for the future climate. Pesticide vapor drift is a two-step process: (a) volatilization of the applied pesticide to vapors and (b) mixing of the vapors with the atmosphere and their transport in the downwind direction. This study dealt with the volatilization part alone. Daily values of maximum and minimum air temperature, averages of relative humidity, wind speed, wet bulb depression and vapor pressure deficit for 56 years from 1959 to 2014 were used for the trend analysis. Wet bulb depression (WBD), indicative of evaporation potential, and vapor pressure deficit (VPD), indicative of the capacity of atmospheric air to accept vapors, were estimated using air temperature and relative humidity (RH). The calendar year weather dataset was trimmed to the cotton growing season based on the results of a precalibrated RZWQM for LMD. The modified Mann Kendall test, Pettitt test and Sen's slope were included in the trend analysis suite using 'R'. The likely changes in volatilization/PVD under climate change were estimated as (a) average qualitative change in PVD for the entire growing season and (b) quantitative changes in PVD at different pesticide application periods during the cotton growing season. Our analysis showed marginal to moderate increases in PVD during most parts of the cotton growing season as a result of climate change patterns of air temperature and RH during the cotton growing season in LMD. Estimated increased volatilization of the postemergent herbicide S-metolachlor application during the middle of July appears to be a concern in the last 20 years that exhibits climate alteration.

946. X-ray source arrays for volumetric imaging during radiotherapy treatment.

Sci Rep

2023 Jun 16

Dillon O, Reynolds T, O'Brien RT.

This work presents a novel hardware configuration for radiotherapy systems to enable fast 3D X-ray imaging before and during treatment delivery. Standard external beam radiotherapy linear accelerators (linacs) have a single X-ray source and detector located at ± 90° from the treatment beam respectively. The entire system can be rotated around the patient acquiring multiple 2D X-ray images to create a 3D cone-beam Computed Tomography (CBCT) image before treatment delivery to ensure the tumour and surrounding organs align with the treatment plan. Scanning with a single source is slow relative to patient respiration or breath holds and cannot be performed during treatment delivery, limiting treatment delivery accuracy in the presence of patient motion and excluding some patients from concentrated treatment plans that would be otherwise expected to have improved outcomes. This simulation study investigated whether recent advances in carbon nanotube (CNT) field emission source arrays, high frame rate (60 Hz) flat panel detectors and compressed sensing reconstruction algorithms could circumvent imaging limitations of current linacs. We investigated a novel hardware configuration incorporating source arrays and high frame rate detectors into an otherwise standard linac. We investigated four potential pre-treatment scan protocols that could be achieved in a 17 s breath hold or 2-10 1 s breath holds. Finally, we demonstrated for the first time volumetric X-ray imaging during treatment delivery by using source arrays, high frame rate detectors and compressed sensing. Image quality was assessed quantitatively over the CBCT geometric field of view as well as across each axis through the tumour centroid. Our results demonstrate that source array imaging enables larger volumes to be imaged with acquisitions as short as 1 s albeit with reduced image quality arising from lower photon flux and shorter imaging arcs.

947. Global contextual attention augmented YOLO with ConvMixer prediction heads for PCB surface defect detection.

Sci Rep

2023 Jun 16

Xia K, Lv Z, Liu K

948. A missense variant at the RAC1-PAK1 binding site of RAC1 inactivates downstream signaling in VACTERL association.

Sci Rep

2023 Jun 16

Seyama R(#), Nishikawa M(#), Uchiyama Y

949. A new multiplex qPCR assay to detect and differentiate big cat species in the illegal wildlife trade.

Sci Rep

2023 Jun 16

Henger CS, Straughan DJ, Xu CCY

950. Cost-minimization analysis of oral versus intravenous antibiotic treatment for Klebsiella pneumoniae liver abscess.

Sci Rep

2023 Jun 16

Yoong J, Yuen KH, Molton JS

951. Temporal instability and differences in injury severity between restrained and unrestrained drivers in speeding-related crashes.

Sci Rep

2023 Jun 16

Se C, Champahom T, Wisutwattanasak P

Upon detecting a crash impact, the vehicle restraint system locks the driver in place. However, external factors such as speeding, crash mechanisms, roadway attributes, vehicle type, and the surrounding environment typically contribute to the driver being jostled within the vehicle. As a result, it is crucial to model unrestrained and restrained drivers separately to reveal the true impact of the restraint system and other factors on driver injury severities. This paper aims to explore the differences in factors affecting injury severity for seatbelt-restrained and unrestrained drivers involved in speeding-related crashes while accounting for temporal instability in the investigation. Utilizing crash data from Thailand between 2012 and 2017, mixed logit models with heterogeneity in means and variances were employed to account for multi-layered unobserved heterogeneity. For restrained drivers, the risk of fatal or severe crashes was positively associated with factors such as male drivers, alcohol influence, flush/barrier median roadways, sloped roadways, vans, running off the roadway without roadside guardrails, and nighttime on unlit or lit roads. For unrestrained drivers, the likelihood of fatal or severe injuries increased in crashes involving older drivers, alcohol influence, raised or depressed median roadways, four-lane roadways, passenger cars, running off the roadway without roadside guardrails, and crashes occurring in rainy conditions. The out-of-sample prediction simulation results are particularly significant, as they show the maximum safety benefits achievable solely by using a vehicle's seatbelt system. Likelihood ratio test and predictive comparison findings highlight the considerable combined impact of temporal instability and the non-transferability of restrained and unrestrained driver injury severities across the periods studied. This finding also demonstrates a potential reduction in severe and fatal injury rates by simply replicating restrained driver conditions. The findings should be of value to policymakers, decision-makers, and highway engineers when developing potential countermeasures to improve driver safety and reduce the frequency of severe and fatal speeding-related single-vehicle crashes.

952. Egg-mediated maternal effects in a cooperatively breeding cichlid fish.

Sci Rep

2023 Jun 16

Reyes-Contreras M, de Vries B, van der Molen JC

953. Ontogenetic transitions, biomechanical trade-offs and macroevolution of scyphozoan medusae swimming patterns.

Sci Rep

2023 Jun 16

von Montfort GM, Costello JH, Colin SP

954. Multi-parental fungal mapping population study to detect genomic regions associated with Pyrenophora teres f. teres virulence.

Sci Rep

2023 Jun 16

Dahanayaka BA, Martin A.

955. Sitagliptin ameliorates busulfan-induced pulmonary and testicular injury in rats through antioxidant, anti-inflammatory, antifibrotic, and antiapoptotic effects.

Sci Rep

2023 Jun 16

Ali EA, Tayel SG, Abbas MA.

956. Mental health problems and resilience in adolescents during the COVID-19 pandemic in a post-armed conflict area in Colombia.

Sci Rep

2023 Jun 16

Gómez-Restrepo C, Sarmiento-Suárez MJ, Alba-Saavedra M

The impact of COVID-19 pandemic on mental health of adolescents are emerging and require particular attention in settings where challenges like armed conflict, poverty and internal displacement have previously affected their mental wellbeing. This study aimed to determine the prevalence of anxiety symptoms, depressive symptomatology, probable post-traumatic stress disorder and resilience in school-attending adolescents in a post-conflict area of Tolima, Colombia during the COVID-19. A cross-sectional study was carried out with 657 adolescents from 12 to 18 years old, recruited by convenience sampling in 8 public schools in the south of Tolima, Colombia, who completed a self-administered questionnaire. Mental health information was obtained through screening scales for anxiety symptoms (GAD-7), depressive symptomatology (PHQ-8), probable post-traumatic stress disorder (PCL-5) and resilience (CD-RISC-25). The prevalence observed for moderate to severe anxiety symptoms was 18.9% (95% CI 16.0-22.1) and for moderate to severe depressive symptomatology was 30.0% (95% CI 26.5-33.7). A prevalence of probable post-traumatic stress disorder (PTSD) of 22.3% (95% CI 18.1-27.2) was found. The CD-RISC-25 results for resilience had a median score of 54 [IQR 30]. These results suggest that approximately two-thirds of school-attending adolescents in this post-conflict area experienced at least one mental health problem such as anxiety symptoms, depressive symptomatology or probable PTSD during the COVID-19 pandemic. Future studies are of interest to establish the causal relationship between these findings and the impact of the pandemic. These findings highlight the challenge that schools have after pandemic to address the mental health of their students in order to promoting adequate coping strategies and implement prompt multidisciplinary interventions to reduce the burden of mental health problems in adolescents.

957. Defining an optimal control for RNAi experiments with adult Schistosoma mansoni.

Sci Rep

2023 Jun 16

Moescheid MF(#), Puckelwaldt O(#), Beutler M

958. Applying in-situ visible photopolymerization for fabrication of electrospun nanofibrous carrier for meloxicam delivery.

Sci Rep

2023 Jun 16

Ahmadipour Z, Seyed Dorraji MS, Ashjari HR

959. A novel prognostic model for hepatocellular carcinoma based on pyruvate metabolism-related genes.

Sci Rep

2023 Jun 16

Shi Q(#), Xue C(#), Zeng Y

960. Gas stripping assisted vapour permeation using graphene membrane on silicon carbide for ethanol recovery.

Sci Rep

2023 Jun 16

Carrio JAG, Talluri VP, Toolahalli ST

961. Using nanopore sequencing to identify fungi from clinical samples with high phylogenetic resolution.

Sci Rep

2023 Jun 16

Ohta A, Nishi K, Hirota K

962. Biogenic production of silver, zinc oxide, and cuprous oxide nanoparticles, and their impregnation into textiles with antiviral activity against SARS-CoV-2.

Sci Rep

2023 Jun 16

Asmat-Campos D, Rojas-Jaimes J, de Oca-Vásquez GM

963. HIV status and survival of patients with pulmonary hypertension due to left heart disease: the Pan African Pulmonary Hypertension Cohort.

Sci Rep

2023 Jun 16

Katoto PDMC, Mukasa SL, Sani MU

964. Investigating the use of titanium dioxide (TiO(2)) nanoparticles on the amount of protection against UV irradiation.

Sci Rep

2023 Jun 16

Ghamarpoor R, Fallah A, Jamshidi M.

965. Efficacy and safety of add-on anti-CD20 monoclonal antibody to Bruton tyrosine kinase inhibitor treatment for chronic lymphocytic leukemia: a meta-analysis.

Sci Rep

2023 Jun 16

Nguyen TT, Nhu NT, Tran VK

966. CXCL10 as a shared specific marker in rheumatoid arthritis and inflammatory bowel disease and a clue involved in the mechanism of intestinal flora in rheumatoid arthritis.

Sci Rep

2023 Jun 16

Guan Y, Zhang Y, Zhu Y

967. Genomic studies of the additive and dominant genetic control on production traits of Euterpe edulis fruits.

Sci Rep

2023 Jun 16

Canal GB, Oliveira GF, de Almeida FAN

968. Measuring the diversity gap of cannabis clinical trial participants compared to people who report using cannabis.

Sci Rep

2023 Jun 16

Barkholtz H, Bates M.

969. Detecting common coccinellids found in sorghum using deep learning models.

Sci Rep

2023 Jun 16

Wang C, Grijalva I, Caragea D

Increased global production of sorghum has the potential to meet many of the demands of a growing human population. Developing automation technologies for field scouting is crucial for long-term and low-cost production. Since 2013, sugarcane aphid (SCA) Melanaphis sacchari (Zehntner) has become an important economic pest causing significant yield loss across the sorghum production region in the United States. Adequate management of SCA depends on costly field scouting to determine pest presence and economic threshold levels to spray insecticides. However, with the impact of insecticides on natural enemies, there is an urgent need to develop automated-detection technologies for their conservation. Natural enemies play a crucial role in the management of SCA populations. These insects, primary coccinellids, prey on SCA and help to reduce unnecessary insecticide applications. Although these insects help regulate SCA populations, the detection and classification of these insects is time-consuming and inefficient in lower value crops like sorghum during field scouting. Advanced deep learning software provides a means to perform laborious automatic agricultural tasks, including detection and classification of insects. However, deep learning models for coccinellids in sorghum have not been developed. Therefore, our objective was to develop and train machine learning models to detect coccinellids commonly found in sorghum and classify them according to their genera, species, and subfamily level. We trained a two-stage object detection model, specifically, Faster Region-based Convolutional Neural Network (Faster R-CNN) with the Feature Pyramid Network (FPN) and also one-stage detection models in the YOLO (You Only Look Once) family (YOLOv5 and YOLOv7) to detect and classify seven coccinellids commonly found in sorghum (i.e., Coccinella septempunctata, Coleomegilla maculata, Cycloneda sanguinea, Harmonia axyridis, Hippodamia convergens, Olla v-nigrum, Scymninae). We used images extracted from the iNaturalist project to perform training and evaluation of the Faster R-CNN-FPN and YOLOv5 and YOLOv7 models. iNaturalist is an imagery web server used to publish citizen's observations of images pertaining to living organisms. Experimental evaluation using standard object detection metrics, such as average precision (AP), AP@0.50, etc., has shown that the YOLOv7 model performs the best on the coccinellid images with an AP@0.50 as high as 97.3, and AP as high as 74.6. Our research contributes automated deep learning software to the area of integrated pest management, making it easier to detect natural enemies in sorghum.

970. The overexpression and clinical significance of TBX15 in human gliomas.

Sci Rep

2023 Jun 16

Yan D(#), Yu Y(#), Ni Q(#)

971. Global spatial distribution of Chromolaena odorata habitat under climate change: random forest modeling of one of the 100 worst invasive alien species.

Sci Rep

2023 Jun 16

Adhikari P(#), Lee YH(#), Poudel A

972. Investigation of the potential role of fusicoccin, a fungal phytotoxin, in mitigating salt stress in onion roots.

Sci Rep

2023 Jun 16

Çavuşoğlu K(#), Çavuşoğlu D(#).

973. Differential thermal analysis techniques as a tool for preliminary examination of catalyst for combustion.

Sci Rep

2023 Jun 16

Yurchenko O, Pernau HF, Engel L

974. Sex-dependent performance differences in curvilinear aiming arm movements in octogenarians.

Sci Rep

2023 Jun 16

Kutz DF, Fröhlich S, Rudisch J

975. Linking paranormal and conspiracy beliefs to illusory pattern perception through signal detection theory.

Sci Rep

2023 Jun 16

Müller P, Hartmann M.

976. The possible role of sodium leakage channel localization factor-1 in the pathophysiology and severity of autism spectrum disorders.

Sci Rep

2023 Jun 16

Al-Mazidi S, Al-Ayadhi L, Alqahtany F

977. Home range ecology of Indian rock pythons (Python molurus) in Sathyamangalam and Mudumalai Tiger Reserves, Tamil Nadu, Southern India.

Sci Rep

2023 Jun 16

Vishnu CS, Marshall BM, Ramesh C

978. Simulated nanoindentation into single-phase fcc Fe[Formula: see text]Ni[Formula: see text] alloys predicts maximum hardness for equiatomic stoichiometry.

Sci Rep

2023 Jun 16

Alabd Alhafez I, Deluigi OR, Tramontina D

979. The effect of hospital-based health promotion on the health practices of full-time hospital nurses: a cross-sectional study.

Sci Rep

2023 Jun 16

Chen HH(#), Lai JC(#), Chiou ST

980. Human mobility patterns are associated with experienced partisan segregation in US metropolitan areas.

Sci Rep

2023 Jun 16

Zhang Y, Cheng S, Li Z

981. Adaptive parameter estimation for the expanded sandwich model.

Sci Rep

2023 Jun 16

Yang G, Zhang H, Liu Y

982. Integrative transcriptome and proteome analyses of clear cell renal cell carcinoma develop a prognostic classifier associated with thrombus.

Sci Rep

2023 Jun 16

Shi X(#), Pang Q(#), Nian X(#)

Clear cell renal cell carcinoma (ccRCC) with venous tumor thrombus (VTT) is associated with poor prognosis. Our integrative analyses of transcriptome and proteome reveal distinctive molecular features of ccRCC with VTT, and yield the development of a prognostic classifier to facilitate ccRCC molecular subtyping and treatment. The RNA sequencing and mass spectrometry were performed in normal-tumor-thrombus tissue triples of five ccRCC patients. Statistical analysis, GO and KEGG enrichment analysis, and protein-protein interaction network construction were used to interpret the transcriptomic and proteomic data. A six-gene-based classifier was developed to predict patients' survival using Cox regression, which was validated in an independent cohort. Transcriptomic analysis identified 1131 tumorigenesis-associated differentially expressed genes (DEGs) and 856 invasion-associated DEGs. Overexpression of transcription factor EGR2 in VTT indicated its important role in tumor invasion. Furthermore, proteomic analysis showed 597 tumorigenesis-associated differentially expressed proteins (DEPs) and 452 invasion-associated DEPs. The invasion-associated DEPs showed unique enrichment in DNA replication, lysine degradation, and PPAR signaling pathway. Integration of transcriptome and proteome reveals 142 tumorigenesis-associated proteins and 84 invasion-associated proteins displaying changes consistent with corresponding genes in transcriptomic profiling. Based on their different expression patterns among normal-tumor-thrombus triples, RAB25 and GGT5 were supposed to play a consistent role in both tumorigenesis and invasion processes, while SHMT2 and CADM4 might play the opposite roles in tumorigenesis and thrombus invasion. A prognostic classifier consisting of six DEGs (DEPTOR, DPEP1, NAT8, PLOD2, SLC7A5, SUSD2) performed satisfactorily in predicting survival of ccRCC patients (HR = 4.41, P < 0.001), which was further validated in an independent cohort of 40 cases (HR = 5.52, P = 0.026). Our study revealed the transcriptomic and proteomic profiles of ccRCC patients with VTT, and identified the distinctive molecular features associated with VTT. The six-gene-based prognostic classifier developed by integrative analyses may facilitate ccRCC molecular subtyping and treatment.

983. Deep learning to automatically evaluate HER2 gene amplification status from fluorescence in situ hybridization images.

Sci Rep

2023 Jun 16

Xue T(#), Chang H(#), Ren M

984. A reinforcement learning approach to airfoil shape optimization.

Sci Rep

2023 Jun 16

Dussauge TP(#), Sung WJ(#), Pinon Fischer OJ(#)

985. Observations of the delayed-choice quantum eraser using coherent photons.

Sci Rep

2023 Jun 16

Kim S, Ham BS.

986. Photo-elasticity of silk fibroin harnessing whispering gallery modes.

Sci Rep

2023 Jun 16

Korakas N, Vurro D, Tsilipakos O

987. Hepatitis A seroprevalence, vaccination status and demographic determinants in children and adolescents in Germany, 2014-2017, a population-based study.

Sci Rep

2023 Jun 16

Enkelmann J, Kuhnert R, Stark K

988. Wavelength dependence of ultraviolet light inactivation for SARS-CoV-2 omicron variants.

Sci Rep

2023 Jun 15

Fujimoto N, Nagaoka K, Tatsuno I

989. The impact of small-scale green infrastructure on the affective wellbeing associated with urban sites.

Sci Rep

2023 Jun 15

Navarrete-Hernandez P, Laffan K.

990. Cognitive map formation in the blind is enhanced by three-dimensional tactile information.

Sci Rep

2023 Jun 15

Bleau M, van Acker C, Martiniello N

991. The anxiolytic effects of preoperative administration of pregabalin in comparison to diazepam and placebo.

Sci Rep

2023 Jun 15

Nimmaanrat S, Charuenporn B, Jensen MP

We aimed to evaluate the potential anxiolytic effects of premedication with pregabalin, compared with diazepam and placebo. We conducted this non-inferiority, double-blind, randomized controlled trial in ASA classification I-II patients aged 18-70 years, scheduled for elective surgery under general anesthesia. They were allocated to receive pregabalin (75 mg the night before surgery and 150 mg 2 h before surgery), diazepam (5 and 10 mg in the same manner) or placebo. Preoperative anxiety was evaluated using verbal numerical rating scale (VNRS) and Amsterdam Preoperative Anxiety and Information Scale (APAIS) before and after premedication. Sleep quality, sedation level, and adverse effects were assessed as secondary outcomes. A total of 231 patients were screened and 224 completed the trial. The mean change (95%CI) in anxiety scores from before to after medication in pregabalin, diazepam, and placebo groups for VNRS were - 0.87 (- 1.43, - 0.30), - 1.17 (- 1.74, - 0.60), and - 0.99 (- 1.56, - 0.41), and for APAIS were - 0.38 (- 1.04, 0.28), - 0.83 (- 1.49, - 0.16), and - 0.27 (- 0.95, 0.40). The difference in change for pregabalin versus diazepam was 0.30 (- 0.50, 1.11) for VNRS and 0.45 (- 0.49, 1.38) for APAIS, exceeding the limit of inferiority for APAIS of 1.3. Sleep quality was statistically different between pregabalin and placebo groups (p = 0.048). Sedation in pregabalin and diazepam groups were significantly higher than placebo group (p = 0.008). No significant differences of other side effects, except dry mouth was higher in placebo group compared with diazepam (p = 0.006). The study filed to provide evidence at non-inferiority of pregabalin compared to diazepam. Furthermore, premedication with either pregabalin or diazepam did not significantly reduce the preoperative anxiety in comparison to placebo, despite the fact that both resulted in higher levels of sedation. Clinicians should weigh the benefits and risks of premedication with these 2 drugs.Thai Clinical Trials Registry: TCTR20190424001 (24/04/2019) Registry URL: https://www.thaiclinicaltrials.org/ .

992. Multiscale characterization and contact performance analysis of machining surfaces.

Sci Rep

2023 Jun 15

Li L, Zhang W, Wang J

993. Inhibition of cell cycle-dependent hyphal and biofilm formation by a novel cytochalasin 19,20‑epoxycytochalasin Q in Candida albicans.

Sci Rep

2023 Jun 15

Watchaputi K, Jayasekara LACB, Ratanakhanokchai K

Biofilm-mediated drug resistance is a key virulence factor of pathogenic microbes that cause a serious global health threat especially in immunocompromised individuals. Here, we investigated the antihyphal and antibiofilm activity of 19,20‑epoxycytochalasin Q (ECQ), a cytochalasin actin inhibitor isolated from medicinal mushroom Xylaria sp. BCC1067 against Candida albicans. Remarkably, 256 µg/ml of ECQ inhibited over 95% of C. albicans hyphal formation after 24 h-treatment. Combined ECQ and lipid-based biosurfactant effectively enhanced the antihyphal activity, lowering required ECQ concentrations. Hyphal fragmentation and reduction of biofilm biomass, shown by SEM and AFM visualization of ECQ-treated biofilms, were well corelated to the reduced metabolic activities of young and 24 h-preformed C. albicans biofilms. Induced intracellular accumulation of reactive oxygen species (ROS) also occurred in accompany with the leakage of shrunken cell membrane and defective cell wall at increasing ECQ concentrations. Transcriptomic analyses via RNA-sequencing revealed a massive change (> 1300 genes) in various biological pathways, following ECQ-treatment. Coordinated expression of genes, associated with cellular response to drugs, filamentous growth, cell adhesion, biofilm formation, cytoskeleton organization, cell division cycle, lipid and cell wall metabolisms was confirmed via qRT-PCR. Protein-protein association tool identified coupled expression between key regulators of cell division cyclin-dependent kinases (Cdc19/28) and a gamma-tubulin (Tub4). They coordinated ECQ-dependent hyphal specific gene targets of Ume6 and Tec1 during different phases of cell division. Thus, we first highlight the antihyphal and antibiofilm property of the novel antifungal agent ECQ against one of the most important life-threatening fungal pathogens by providing its key mechanistic detail in biofilm-related fungal infection.

994. The longer-term impact of the COVID-19 pandemic on wellbeing and subjective cognitive functioning of older adults in Belgium.

Sci Rep

2023 Jun 15

De Pue S, Gillebert C, Dierckx E

995. Prosopis juliflora hydrothermal synthesis of high fluorescent carbon dots and its antibacterial and bioimaging applications.

Sci Rep

2023 Jun 15

Prathap N, Balla P, Shivakumar MS

996. Zinc oxide nanostructures enhanced photoluminescence by carbon-black nanoparticles in Moiré heterostructures.

Sci Rep

2023 Jun 15

Wang CC(#), Lo AY(#), Cheng MC

997. Visiting nature is associated with lower socioeconomic inequalities in well-being in Wales.

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2023 Jun 15

Garrett JK(#), Rowney FM(#), White MP

998. Drug resistance related genes in lung adenocarcinoma predict patient prognosis and influence the tumor microenvironment.

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2023 Jun 15

Yu H(#), Zhang W(#), Xu XR

999. Adolescent leisure reading and its longitudinal association with prosocial behavior and social adjustment.

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2023 Jun 15

Lenhart J, Richter T, Appel M

1000. Population structure and genetic diversity of the endangered fish black shinner Pseudopungtungia nigra (Cyprinidae) in Korea: a wild and restoration population.

Sci Rep

2023 Jun 15

Kim KR, Kwak YH, Sung MS

1001. Remodeling of the focal adhesion complex by hydrogen-peroxide-induced senescence.

Sci Rep

2023 Jun 15

Grandy C, Port F, Radzinski M

1002. Reading and lexical-semantic retrieval tasks outperforms single task speech analysis in the screening of mild cognitive impairment and Alzheimer's disease.

Sci Rep

2023 Jun 15

Martínez-Nicolás I, Martínez-Sánchez F, Ivanova O

1003. Slow and population specific evolutionary response to a warming environment.

Sci Rep

2023 Jun 15

Santos MA, Antunes MA, Grandela A

1004. Extreme climatic events to intensify over the Lake Victoria Basin under global warming.

Sci Rep

2023 Jun 15

Ogega OM, Scoccimarro E, Misiani H

1005. A computational approach to design a polyvalent vaccine against human respiratory syncytial virus.

Sci Rep

2023 Jun 15

Moin AT, Ullah MA(#), Patil RB(#)

1006. Diagnostic ability of deep learning in detection of pancreatic tumour.

Sci Rep

2023 Jun 15

Dinesh MG, Bacanin N, Askar SS

Pancreatic cancer is associated with higher mortality rates due to insufficient diagnosis techniques, often diagnosed at an advanced stage when effective treatment is no longer possible. Therefore, automated systems that can detect cancer early are crucial to improve diagnosis and treatment outcomes. In the medical field, several algorithms have been put into use. Valid and interpretable data are essential for effective diagnosis and therapy. There is much room for cutting-edge computer systems to develop. The main objective of this research is to predict pancreatic cancer early using deep learning and metaheuristic techniques. This research aims to create a deep learning and metaheuristic techniques-based system to predict pancreatic cancer early by analyzing medical imaging data, mainly CT scans, and identifying vital features and cancerous growths in the pancreas using Convolutional Neural Network (CNN) and YOLO model-based CNN (YCNN) models. Once diagnosed, the disease cannot be effectively treated, and its progression is unpredictable. That's why there's been a push in recent years to implement fully automated systems that can sense cancer at a prior stage and improve diagnosis and treatment. The paper aims to evaluate the effectiveness of the novel YCNN approach compared to other modern methods in predicting pancreatic cancer. To predict the vital features from the CT scan and the proportion of cancer feasts in the pancreas using the threshold parameters booked as markers. This paper employs a deep learning approach called a Convolutional Neural network (CNN) model to predict pancreatic cancer images. In addition, we use the YOLO model-based CNN (YCNN) to aid in the categorization process. Both biomarkers and CT image dataset is used for testing. The YCNN method was shown to perform well by a cent percent of accuracy compared to other modern techniques in a thorough review of comparative findings.

1007. Seasonal estimation of groundwater vulnerability.

Sci Rep

2023 Jun 15

Cervantes-Servin AI, Arora M, Peterson TJ

1008. DFT and QSAR studies of PTFE/ZnO/SiO(2) nanocomposite.

Sci Rep

2023 Jun 15

Ezzat HA, Hegazy MA, Ghoneim R

1009. Predicting the relationship between pesticide genotoxicity and breast cancer risk in South Indian women in in vitro and in vivo experiments.

Sci Rep

2023 Jun 15

Sasikala S, Minu Jenifer M, Velavan K

1010. Magnetic field coupling with lunar soil simulants.

Sci Rep

2023 Jun 15

Garman SM, Roth MC, Roux VG

1011. Biogenic apatite in carbonate concretions with and without fossils investigated in situ by micro-Raman spectroscopy.

Sci Rep

2023 Jun 15

Kitanaka R, Tsuboi M, Ozaki Y.

1012. Urinary titin N-fragment as a predictor of decreased skeletal muscle mass in patients with interstitial lung diseases.

Sci Rep

2023 Jun 15

Hanada M, Ishimatsu Y, Sakamoto N

1013. Embryonic abnormalities and genotoxicity induced by 2,4-dichlorophenoxyacetic acid during indirect somatic embryogenesis in Coffea.

Sci Rep

2023 Jun 15

de Morais Oliveira JP, Silva AJD, Catrinck MN

1014. Differences in engineers' brain activity when CAD modelling from isometric and orthographic projections.

Sci Rep

2023 Jun 15

Lukačević F, Becattini N, Perišić MM

A way of presenting information in visual representations of technical systems influences the progress and the outcome of the engineering design process. Consequently, improving the means by and through which information is utilised during the process is one suggested approach to advancing engineering design. Engineers' interaction with visual representations of technical systems is mainly visual and virtual. Although such interactions are cognitively complex, little is known about cognition (mental information processing) underlying the utilisation of design information during engineering design. To narrow the research gap, this study explores how visual representations of technical systems affect engineers' brain activity while generating computer-aided design (CAD) models based on them. More precisely, the brain activity of 20 engineers is captured and analysed using electroencephalography (EEG) during the visuospatially-intensive design tasks of CAD modelling in two conditions; when technical systems are presented with orthographic and isometric projections in technical drawings. The results imply the sensitivity of engineers' brain activity in CAD modelling to the visual representation from which a technical system is interpreted. In particular, significant differences are found in theta, alpha, and beta task-related power (TRP) over the cortex when interpreting the technical drawings and CAD modelling from them. Furthermore, the results reveal significant differences in theta and alpha TRP when considering the individual electrodes, the cortical hemispheres, and the cortical areas. In particular, theta TRP over the right hemisphere and the frontal area seems essential in distinguishing neurocognitive responses to the orthographic and isometric projections. As such, the conducted exploratory study sets the foundations for exploring engineers' brain activity while performing visuospatially-intensive design tasks, whose segments are relatable to the aspects of visuospatial thinking. Future work will explore brain activity in other design activities that are highly visuospatial, with a larger sample size and an EEG device of a higher spatial resolution.

1015. Characterization, sources, and risk assessment of PAHs in borehole water from the vicinity of an unlined dumpsite in Awka, Nigeria.

Sci Rep

2023 Jun 15

Aralu CC, Okoye PC, Abugu HO

1016. Metabolic engineering of Halomonas campaniensis strain XH26 to remove competing pathways to enhance ectoine production.

Sci Rep

2023 Jun 15

Shu Z, Zhang X, Wang R

1017. Facial mimicry and metacognitive judgments in emotion recognition are distinctly modulated by social anxiety and autistic traits.

Sci Rep

2023 Jun 15

Folz J, Akdağ R, Nikolić M

1018. Disparities in insecurity, social support, and family relationships in association with poor mental health among US adults during the COVID-19 pandemic.

Sci Rep

2023 Jun 15

Zhu K, Wang S, Yue Y

1019. Cis-regulatory elements and transcription factors related to auxin signaling in the streptophyte algae Klebsormidium nitens.

Sci Rep

2023 Jun 15

Tounosu N, Sesoko K, Hori K

1020. Changes in plasticity of the pelvic girdle from infancy to late adulthood in Homo sapiens.

Sci Rep

2023 Jun 15

Kubicka AM.

1021. Optimized testing strategy for the diagnosis of GAA-FGF14 ataxia/spinocerebellar ataxia 27B.

Sci Rep

2023 Jun 15

Bonnet C(#), Pellerin D(#), Roth V

1022. Characterization of a new natural novel lignocellulose fiber resource from the stem of Cyperus platystylis R.Br.

Sci Rep

2023 Jun 15

Bhunia AK, Mondal D, Parui SM

1023. The first comprehensive population size estimations for the highly endangered largest diving beetle Dytiscus latissimus in Europe.

Sci Rep

2023 Jun 15

Balalaikins M, Schmidt G, Aksjuta K

Dytiscus latissimus (Coleoptera Dytiscidae) is an endangered diving beetle throughout its range. It is one of the two species of Dytiscidae listed in Annex II of the Habitats Directive, IUCN red list and in many national level legislations and therefore strictly protected. The conservation of endangered species first of all requires an assessment of their population size. Until now, a method has not been developed for estimating the size of D. latissimus populations. The article summarizes the results of two studies carried out independently in Germany and Latvia. Both studies were carried out in one water body used recapture method but with a different spatial placement of traps, which, according to our data, is an important factor in population estimation. We evaluated Jolly-Seber and Schnabel approaches of estimating aquatic beetle's populations and found that confidence intervals obtained by different methods in our research do not differ significantly, but combination of both models provide the most accurate estimates of population dynamics. As part of the study, we concluded that the populations of Dytiscus latissimus are relatively closed, so we accept that the Schnabel estimate shows more accurate data. By fixing the places of capture of each individual, it was found that females live mainly locally, and males actively move within the water body. This aspect indicates the advantage of the spatial placement of traps compared to the use of transects. The results of our study show a significantly higher number of both captured and recaptured males Such a sex ratio may indicate both a greater activity of males and differences in the sex ratio in the population. The study confirmed that environmental changes, such as the water level in a water body, can also significantly affect the result of a population assessment. In the frame of D. latissimus monitoring, to obtain an objective estimation of the species population size we recommend using four traps for each 100 m of water body shoreline with 4-8 censuses, dependently on the recapture rate.

1024. High endemicity of Opisthorchis viverrini infection among people in northern Cambodia confirmed by adult worm expulsion.

Sci Rep

2023 Jun 14

Jung BK, Hong S, Chang T

Opisthorchis viverrini infection is an emerging disease in Cambodia, especially in central and southeastern areas. However, its status in northern areas bordering Lao PDR has been relatively unknown. The present study was performed to investigate the status of O. viverrini infection among people in Preah Vihear and Stung Treng provinces through fecal examination to detect eggs and recovery of adult flukes from some of the egg-positive cases. Fecal examinations were performed on a total of 1101 people from 10 villages in the 2 provinces using the Kato-Katz thick smear technique. For recovery of adult flukes and other helminth parasites 10 volunteers positive for eggs of Opisthorchis viverrini and/or minute intestinal flukes (Ov/MIF), in Kampong Sangkae village, Preah Vihear province, were administered a single oral dose of 40 mg/kg praziquantel plus 5-10 mg/kg of pyrantel pamoate and purged with 40-50 g magnesium salts. Adult trematodes, together with nematodes and cestodes expelled in diarrheic stools were collected under a stereomicroscope or with the naked eye. The proportion of egg-positive cases for overall liver and intestinal helminths was high but not notably different between the 2 provinces, 65.5% in Preah Vihear versus 64.7% in Stung Treng. The average proportion of Ov/MIF egg-positive cases was 59.8%. A total of 315 adult specimens of O. viverrini were recovered from the 10 volunteers (4-98 specimens per individual; mean, 32). A smaller number of Haplorchis taichui adults, an intestinal fluke, were found mixed-infected in 7 (103 specimens in total; 1-31 per individual; mean, 15) of the 10 volunteers. Adult specimens of hookworms, Enterobius vermicularis, Trichostrongylus sp., and a Taenia tapeworm strobila were recovered in some cases. Based on the results, it has been confirmed that the surveyed areas in Preah Vihear and Stung Treng provinces, Cambodia, are highly endemic areas of O. viverrini infection with a low-grade mixed infection with H. taichui.

1025. A numerical analysis of inclination and rectification of ramp-bridge piers adjacent to surcharge load in soft clay area.

Sci Rep

2023 Jun 14

Shen B, Mao D, Ding Y

The surrounding surcharge has an adverse impact on the service performance of buildings and bridges, and it can endanger their structural safety, especially in soft soil areas. As one case study, the inclination accident of an expressway ramp bridge and its rectification are investigated in this study. Through the three-dimensional (3D) finite element (FE) analysis of the overall structures composed of the bridge span, the pier, and the pile foundation, the whole process of the inclination by the adjacent dumped earth, partial recovery by the unloading, and the lateral pushing rectification of the bridge structure were simulated. The results show that the surcharge load leads to soil displacement near the bridge pile, and the pile-soil interaction leads to the pile deformation, which further causes the inclination of the pier, and the movement of the bridge span. The severity of the accident can be measured by the inclination of the piers and the opening widths of the bridge expansion joints. Due to the plastic deformation and drainage consolidation of the soft clay foundation under the surcharge load, the inclination of the piles and piers cannot be fully recovered after unloading. In order to capture these processes, the FE simulation was divided into three steps. First, the drainage consolidation of the soil foundation were identified by FE simulation and the field measurement of the recovery of the structure after unloading. Second, the effects of soil properties, the surcharge time and surcharge strength on the bridge inclination and the recovery capacity after unloading are discussed. Finally, the rectification of the bridge by lateral pushing was simulated, and the deformation and stress in the pier and pile were calculated to evaluate the safety of the structures. These analyses provided understanding towards the prevention of the bridge inclination under surcharge load, prediction of the recovery by the unloading, and the methods to reduce the residual deformation to meet the specifications.

1026. Dynamic contrast enhanced (DCE) MRI estimation of vascular parameters using knowledge-based adaptive models.

Sci Rep

2023 Jun 14

Bagher-Ebadian H, Brown SL, Ghassemi MM

1027. Physiological and transcriptomic analysis of a yellow leaf mutant in watermelon.

Sci Rep

2023 Jun 14

Xu B(#), Zhang C(#), Gu Y

1028. Localization of the ventricular pacing site from BSPM and standard 12-lead ECG: a comparison study.

Sci Rep

2023 Jun 14

Sedova KA, van Dam PM, Blahova M

1029. ABCA1 deficiency contributes to podocyte pyroptosis priming via the APE1/IRF1 axis in diabetic kidney disease.

Sci Rep

2023 Jun 14

Ito M, Ducasa GM, Molina JD

1030. A fast magnetic vector characterization method for quasi two-dimensional systems and heterostructures.

Sci Rep

2023 Jun 14

Herguedas-Alonso AE, Aballe L, Fullerton J

1031. Association between inter-arm blood pressure difference and cardiovascular disease: result from baseline Fasa Adults Cohort Study.

Sci Rep

2023 Jun 14

Sharafi M, Amiri Z, Haghjoo E

1032. Local and wide-scale livestock movement networks inform disease control strategies in East Africa.

Sci Rep

2023 Jun 14

Ekwem D, Enright J, Hopcraft JGC

1033. Reduced vmPFC-insula functional connectivity in generalized anxiety disorder: a Bayesian confirmation study.

Sci Rep

2023 Jun 14

Steinhäuser JL, Teed AR, Al-Zoubi O

1034. Resonant plasmonic detection of terahertz radiation in field-effect transistors with the graphene channel and the black-As[Formula: see text]P[Formula: see text] gate layer.

Sci Rep

2023 Jun 14

Ryzhii V, Tang C, Otsuji T

1035. Design optimization and experiment of corn U-shaped fertilization device.

Sci Rep

2023 Jun 14

Zuo Z, Zhao J, Yin B

Aiming at the problems of low utilization rate of corn fertilizer, low precision of fertilization ratio, and time-consuming and laborious topdressing in the later stage, an U-shaped fertilization device with uniform fertilizer mechanism was designed. The device was mainly composed of uniform fertilizer mixing mechanism, fertilizer guide plate and fertilization plate. Compound fertilizer was applied on both sides and slow/controlled release fertilizer was applied at the bottom to form an U-shaped distribution of fertilizer around corn seeds. Through theoretical analysis and calculation, the structural parameters of the fertilization device were determined. Through the simulated soil tank test, the quadratic regression orthogonal rotation combination design was carried out on the main factors affecting the spatial stratification effect of fertilizer. The optimal parameters were obtained as follows: the stirring speed of the stirring structure was 300 r/min, the bending angle of the fertilization tube was 165°, and the operating speed of the fertilization device was 3 km/h. The results of bench verification test showed that under the optimized stirring speed and bending angle, the fertilizer particles were stirred evenly, and the average values of fertilizer flowing out of the fertilization tubes on both sides were 299.5 g and 297.4 g, respectively. The average fertilizer amounts of the three fertilizer outlets were 200.4 g, 203.2 g and 197.7 g, respectively, which met the agronomic requirements of 1:1:1 fertilization, and the variation coefficients of fertilizer amounts on both sides of the fertilizer pipe and each layer were less than 0.1% and 0.4%, respectively. The simulation results of the optimized U-shaped fertilization device can achieve the expected U-shaped fertilization effect around corn seeds. The results of field experiment showed that the U-shaped fertilization device could realize the U-shaped proportional application of fertilizer in soil. The distance between the upper end of fertilization on both sides and the distance between the base fertilizer and the surface were 87.3-95.2 mm and 197.8-206.0 mm, respectively. The transverse distance between the fertilizers on both sides was 84.3-99.4 mm, and the error with the designed theoretical fertilization was within 10 mm. Compared with the traditional side fertilization method, the number of corn roots increased by 5-6, the root length increased by 30-40 mm, and the yield increased by 9.9-14.8%.

1036. Millimeter-wave planar antenna array augmented with a low-cost 3D printed dielectric polarizer for sensing and internet of things (IoT) applications.

Sci Rep

2023 Jun 14

Al-Alem Y, Sifat SM, Antar YMM

1037. Microstructural brain tissue changes contribute to cognitive and mood deficits in adults with type 2 diabetes mellitus.

Sci Rep

2023 Jun 14

Roy B, Choi SE, Freeby MJ

1038. Knowledge, attitudes and intention on fertility preservation among breast cancer patients.

Sci Rep

2023 Jun 14

Ko JKY, Cheung CSY, Cheng HHY

1039. Immunological evaluation of herbal extracts commonly used for treatment of mental diseases during pregnancy.

Sci Rep

2023 Jun 14

Winker M, Chauveau A, Smieško M

Nonpsychotic mental diseases (NMDs) affect approximately 15% of pregnant women in the US. Herbal preparations are perceived a safe alternative to placenta-crossing antidepressants or benzodiazepines in the treatment of nonpsychotic mental diseases. But are these drugs really safe for mother and foetus? This question is of great relevance to physicians and patients. Therefore, this study investigates the influence of St. John's wort, valerian, hops, lavender, and California poppy and their compounds hyperforin and hypericin, protopine, valerenic acid, and valtrate, as well as linalool, on immune modulating effects in vitro. For this purpose a variety of methods was applied to assess the effects on viability and function of human primary lymphocytes. Viability was assessed via spectrometric assessment, flow cytometric detection of cell death markers and comet assay for possible genotoxicity. Functional assessment was conducted via flow cytometric assessment of proliferation, cell cycle and immunophenotyping. For California poppy, lavender, hops, and the compounds protopine and linalool, and valerenic acid, no effect was found on the viability, proliferation, and function of primary human lymphocytes. However, St. John's wort and valerian inhibited the proliferation of primary human lymphocytes. Hyperforin, hypericin, and valtrate inhibited viability, induced apoptosis, and inhibited cell division. Calculated maximum concentration of compounds in the body fluid, as well as calculated concentrations based on pharmacokinetic data from the literature, were low and supported that the observed effects in vitro would probably have no relevance on patients. In-silico analyses comparing the structure of studied substances with the structure of relevant control substances and known immunosuppressants revealed structural similarities of hyperforin and valerenic acid to the glucocorticoids. Valtrate showed structural similarities to the T cells signaling modulating drugs.

1040. CD44 is a potential immunotherapeutic target and affects macrophage infiltration leading to poor prognosis.

Sci Rep

2023 Jun 14

Liu S(#), Liu Z(#), Shang A

1041. Sex difference in the association of the triglyceride glucose index with obstructive coronary artery disease.

Sci Rep

2023 Jun 14

Lu YW(#), Tsai CT(#), Chou RH

1042. Geoeffective interplanetary magnetic field (IMF) from in situ data: realistic versus idealized spiral IMF.

Sci Rep

2023 Jun 14

Bandić M, Verbanac G, Živković S.

1043. Host specificity and adaptive evolution in settlement behaviour of coral-associated barnacle larvae (Cirripedia: Pyrgomatidae).

Sci Rep

2023 Jun 14

Yap FC, Chen HN, Chan BKK.

1044. Mitochondrial complex III activity: from invasive muscle biopsies to patient-friendly buccal swab analysis.

Sci Rep

2023 Jun 14

Somers T, Allard NAE, Siddiqi S

1045. Thoracoscopic segmentectomy in children with congenital lung malformation.

Sci Rep

2023 Jun 14

Joo S(#), Yun T(#), Kang CH

1046. Cisplatin-induced increase in heregulin 1 and its attenuation by the monoclonal ErbB3 antibody seribantumab in bladder cancer.

Sci Rep

2023 Jun 14

Steele TM(#), Tsamouri MM(#), Siddiqui S

1047. Panel of miR-150 and linc00673, regulators of CCR6/CCL20 may serve as non-invasive diagnostic marker of non-small cell lung cancer.

Sci Rep

2023 Jun 14

Baran K, Kordiak J, Jabłoński S

The C-C motif ligand 20 (CCL20) is a chemokine that specifically binds to the chemokine receptor 6 (CCR6) and the CCL20/CCR6 axis has been implicated in the non-small lung cancer (NSCLC) development and progression. Its expression is regulated by mutual interactions of non-coding RNAs (ncRNAs). This goals of presented study was to evaluate the expression level of CCR6/CCL20 mRNA in NSCLC tissue comparative to selected ncRNAs: miR-150, linc00673. The expression level of the studied ncRNAs was also assessed in serum extracellular vesicles (EVs). Thirty patients (n = 30) were enrolled as the study cohort. Total RNA was isolated from tumor tissue, adjacent macroscopically unchanged tissue and serum EVs. The expression level of studied genes and ncRNAs were estimated based on the qPCR method. Higher expression level of CCL20 mRNA but lower expression level of CCR6 mRNA were observed in tumor in comparison to control tissue. Relative to the smoking status, higher CCL20 (p < 0.05) and CCR6 mRNA (p > 0.05) expression levels were observed in current smokers than in never smokers. In serum EVs the expression level of miR-150 has a negative correlation with AJCC tumor staging, whereas the expression level of linc00673 positively correlated (p > 0.05). The lower expression level of miR-150 and higher expression level of linc00673 in serum EVs were observed in NSCLC patients with lymph nodes metastases (p > 0.05). Regarding the histopathological type, significantly lower expression level of miR-150 and higher expression level of linc00673 were observed in the serum EVs of patients with AC compared to patient with SCC. Our findings revealed that smoking significantly changed the expression level of CCL20 mRNA in NSCLC tissue. Changes in expression levels of miR-150 and linc00673 in the serum EVs of NSCLC patients in relation to presence of lymph node metastases and the stage of cancer development may serve as a non-invasive molecular biomarkers of tumor progression. Furthermore, expression levels of miR-150 and linc00673 may serve as non-intrusive diagnostic biomarkers differentiating adenocarcinoma from squamous cell carcinoma.

1048. Structural and functional analysis of a plant nucleolar RNA chaperone-like protein.

Sci Rep

2023 Jun 14

Fernandes R, Ostendorp A, Ostendorp S

1049. Synergistic influence of probiotic and florfenicol on embryonic viability, performance, and multidrug-resistant Salmonella Enteritidis in broiler chickens.

Sci Rep

2023 Jun 14

Nabil NM, Tawakol MM, Samir A

1050. Single neonatal estrogen implant sterilizes female animals by decreasing hypothalamic KISS1 expression.

Sci Rep

2023 Jun 14

Park CJ, Minabe S, Hess RA

1051. Intact mass analysis reveals the novel O-linked glycosylation on the stalk region of PD-1 protein.

Sci Rep

2023 Jun 14

Tit-Oon P, Wonglangka A, Boonkanta K

1052. Cancer-associated fibroblast-derived exosome microRNA-21 promotes angiogenesis in multiple myeloma.

Sci Rep

2023 Jun 14

Miaomiao S(#), Xiaoqian W(#), Yuwei S

1053. Compositional modeling of gas-condensate viscosity using ensemble approach.

Sci Rep

2023 Jun 14

Rezaei F, Akbari M, Rafiei Y

In gas-condensate reservoirs, liquid dropout occurs by reducing the pressure below the dew point pressure in the area near the wellbore. Estimation of production rate in these reservoirs is important. This goal is possible if the amount of viscosity of the liquids released below the dew point is available. In this study, the most comprehensive database related to the viscosity of gas condensate, including 1370 laboratory data was used. Several intelligent techniques, including Ensemble methods, support vector regression (SVR), K-nearest neighbors (KNN), Radial basis function (RBF), and Multilayer Perceptron (MLP) optimized by Bayesian Regularization and Levenberg-Marquardt were applied for modeling. In models presented in the literature, one of the input parameters for the development of the models is solution gas oil ratio (Rs). Measuring Rs in wellhead requires special equipment and is somewhat difficult. Also, measuring this parameter in the laboratory requires spending time and money. According to the mentioned cases, in this research, unlike the research done in the literature, Rs parameter was not used to develop the models. The input parameters for the development of the models presented in this research were temperature, pressure and condensate composition. The data used includes a wide range of temperature and pressure, and the models presented in this research are the most accurate models to date for predicting the condensate viscosity. Using the mentioned intelligent approaches, precise compositional models were presented to predict the viscosity of gas/condensate at different temperatures and pressures for different gas components. Ensemble method with an average absolute percent relative error (AAPRE) of 4.83% was obtained as the most accurate model. Moreover, the AAPRE values for SVR, KNN, MLP-BR, MLP-LM, and RBF models developed in this study are 4.95%, 5.45%, 6.56%, 7.89%, and 10.9%, respectively. Then, the effect of input parameters on the viscosity of the condensate was determined by the relevancy factor using the results of the Ensemble methods. The most negative and positive effects of parameters on the gas condensate viscosity were related to the reservoir temperature and the mole fraction of C11, respectively. Finally, suspicious laboratory data were determined and reported using the leverage technique.

1054. A frame orientation optimisation method for consistent interpretation of kinematic signals.

Sci Rep

2023 Jun 14

Ortigas Vásquez A, Taylor WR, Maas A

In clinical movement biomechanics, kinematic data are often depicted as waveforms (i.e. signals), characterising the motion of articulating joints. Clinically meaningful interpretations of the underlying joint kinematics, however, require an objective understanding of whether two different kinematic signals actually represent two different underlying physical movement patterns of the joint or not. Previously, the accuracy of IMU-based knee joint angles was assessed using a six-degrees-of-freedom joint simulator guided by fluoroscopy-based signals. Despite implementation of sensor-to-segment corrections, observed errors were clearly indicative of cross-talk, and thus inconsistent reference frame orientations. Here, we address these limitations by exploring how minimisation of dedicated cost functions can harmonise differences in frame orientations, ultimately facilitating consistent interpretation of articulating joint kinematic signals. In this study, we present and investigate a frame orientation optimisation method (FOOM) that aligns reference frames and corrects for cross-talk errors, hence yielding a consistent interpretation of the underlying movement patterns. By executing optimised rotational sequences, thus producing angular corrections around each axis, we enable a reproducible frame definition and hence an approach for reliable comparison of kinematic data. Using this approach, root-mean-square errors between the previously collected (1) IMU-based data using functional joint axes, and (2) simulated fluoroscopy-based data relying on geometrical axes were almost entirely eliminated from an initial range of 0.7°-5.1° to a mere 0.1°-0.8°. Our results confirm that different local segment frames can yield different kinematic patterns, despite following the same rotation convention, and that appropriate alignment of reference frame orientation can successfully enable consistent kinematic interpretation.

1055. Lead induces mouse skin fibroblast apoptosis by disrupting intracellular homeostasis.

Sci Rep

2023 Jun 14

Wang H, Wang H, Guan J

1056. Greenhouse gas emission potential of sewage treatment plants in Himachal Pradesh.

Sci Rep

2023 Jun 14

Sharma A, Bhardwaj SK, Aggarwal RK

1057. An FSV analysis approach to verify the robustness of the triple-correlation analysis theoretical framework.

Sci Rep

2023 Jun 14

Wu RMX(#), Zhang Z(#), Zhang H(#)

1058. Polyoxazoline-conjugated porcine serum albumin as an artificial plasma expander for dogs.

Sci Rep

2023 Jun 14

Okamoto W, Usui T, Hasegawa M

1059. Optimizing fluidity and tensile strength of magnetically driven epoxy-cement repair materials based on response surface.

Sci Rep

2023 Jun 14

Qin S, Liu J, Wang X

1060. Functional connectivity discriminates epileptogenic states and predicts surgical outcome in children with drug resistant epilepsy.

Sci Rep

2023 Jun 14

Rijal S(#), Corona L(#), Perry MS

1061. Nesting biology and phylogenetic relationships of the parasitoid-hunting wasp Lindenius pygmaeus armatus (Vander Linden, 1829) (Hymenoptera: Crabronidae).

Sci Rep

2023 Jun 14

Olszewski P, Budrys E, Orlovskytė S

1062. Iron nanoparticle regulate succinate dehydrogenase activity in canola plants under drought stress.

Sci Rep

2023 Jun 14

Rezayian M, Niknam V, Arabloo M.

1063. A collection of cannabinoid-related negative findings from autaptic hippocampal neurons.

Sci Rep

2023 Jun 13

Straiker A, Dvorakova M, Bosquez-Berger T

1064. Critically raw materials as potential emerging environmental contaminants, their distribution patterns, risks and behaviour in floodplain soils contaminated by heavy metals.

Sci Rep

2023 Jun 13

Kanianska R, Drimal M, Varga J

1065. Scale-adaptive model for detection and grading of age-related macular degeneration from color retinal fundus images.

Sci Rep

2023 Jun 13

El-Den NN, Naglah A, Elsharkawy M

1066. Anticancer activity of lactoferrin-coated biosynthesized selenium nanoparticles for combating different human cancer cells via mediating apoptotic effects.

Sci Rep

2023 Jun 13

El-Fakharany EM, Abu-Serie MM, Ibrahim A

1067. Patient-reported distress at a cancer center during the COVID-19 pandemic.

Sci Rep

2023 Jun 13

Shah MP, Rosenthal SW, Roy M

1068. The mortality risk of night-time and daytime insomnia symptoms in an older population.

Sci Rep

2023 Jun 13

Harvey A, Scott H, Melaku YA

1069. People with higher autistic traits show stronger binding for color-shape associations.

Sci Rep

2023 Jun 13

Chen N, Watanabe K, Spence C

1070. Fabrication and biological investigation of a novel star polymer based on magnetic cyclic aromatic polyimide chains.

Sci Rep

2023 Jun 13

Eivazzadeh-Keihan R, Sadat Z, Mohammadi A

1071. Associations of air pollutant concentrations with longitudinal kidney function changes in patients with chronic kidney disease.

Sci Rep

2023 Jun 13

Chung CY, Wu SY, Chiu HH

1072. A biological invasion reduces rates of cannibalism by Japanese toad tadpoles.

Sci Rep

2023 Jun 13

Crossland MR, Shine R, Haramura T.

1073. Social preferences trump emotions in human responses to unfair offers.

Sci Rep

2023 Jun 13

Buskens V, Kovacic I, Rutterkamp E

1074. Slip instability behavior of block rock masses on dynamic-static combined loads.

Sci Rep

2023 Jun 13

Wang K, Shi P, Pan Y

1075. Improved GBS-YOLOv5 algorithm based on YOLOv5 applied to UAV intelligent traffic.

Sci Rep

2023 Jun 13

Liu H(#), Duan X(#), Lou H

1076. Therapeutic potential of stem cells and acitretin on inflammatory signaling pathway-associated genes regulated by miRNAs 146a and 155 in AD-like rats.

Sci Rep

2023 Jun 13

Elzayat EM, Shahien SA, El-Sherif AA

1077. Survival outcomes of patients with metastatic non-small cell lung cancer receiving chemotherapy or immunotherapy as first-line in a real-life setting.

Sci Rep

2023 Jun 13

Belaroussi Y, Bouteiller F, Bellera C

1078. Mechanism of remodeling and local effects in vivo of a new injectable cosmetic filler.

Sci Rep

2023 Jun 13

Sun L, Sun X, Ruan W

By studying the local effects of a new type of injectable cosmetic filler implanted into the animal to explore the mechanism of remodeling and cosmetic effect of this kind of product. Take 12 rabbits and select 4 implantation points on both sides of the spine, respectively, and implant the test sample (PLLA) and negative control sample (HDPE) into the subcutaneous tissues on both sides. In the same way, take another 12 rabbits and implant the marketing control sample (cross-linked sodium hyaluronate) and negative control sample (HDPE) into the subcutaneous tissues on both sides. The animals were executed at 1 week, 4 weeks, 13 weeks and 52 weeks respectively, and Hematoxylin-Eosin staining, Masson trichrome staining and immunofluorescence staining were performed to characterize the local effects in vivo and the expression of type I collagen (Col. I), type III collagen (Col.III) and matrix metalloproteinase 9 (MMP-9). Good histocompatibility of the test sample and the marketing control sample were found. The foreign body reaction of marketing control sample was more intense than that of the test sample after 13 weeks. The foreign body reaction of testing sample was more intense after 52 weeks, while that of the marketing control sample was more stable. With the process of tissue repair, the collagen fibers of test samples and marketing control samples gradually increased after implantation. Type I collagen was mainly found inside the fiber capsule, while type III collagen was mainly found outside. The positive expression of matrix metalloproteinase 9 gradually increased, the positive expression of test samples increased significantly after 52 weeks, while that of marketing control samples did not change significantly. Good histocompatibility of PLLA filler is found. Matrix metalloproteinase 9 participates in foreign body reaction and collagen formation, which can reflect the process of tissue remodeling.

1079. Equation of state for He bubbles in W and model of He bubble growth and bursting near W{100} surfaces derived from molecular dynamics simulations.

Sci Rep

2023 Jun 13

Setyawan W, Dasgupta D, Blondel S

Molecular dynamics (MD) simulations are performed to derive an equation of state (EOS) for helium (He) bubbles in tungsten (W) and to study the growth of He bubbles under a W(100) surface until they burst. We study the growth as a function of the initial nucleation depth of the bubbles. During growth, successive loop-punching events are observed, accompanied by shifts in the depth of the bubble towards the surface. Subsequently, the MD data are used to derive models that describe the conditions that cause the loop punching and bursting events. Simulations have been performed at 500, 933, 1500, 2000, and 2500 K to fit the parameters in the models. To compute the pressure in the bubble at the loop punching and bursting events from the models, we derive an EOS for He bubbles in tungsten with an accompanying volume model to compute the bubble volume for a given number of vacancies ([Formula: see text]), He atoms ([Formula: see text]), and temperature (T). To derive the bubble EOS, we firstly derive the EOS for a free He gas. The derived free-gas EOS can accurately predict all MD data included in the analysis (which span up to 54 GPa at 2500 K). Subsequently, the bubble EOS is derived based on the free-gas EOS by correcting the gas density to account for the interaction between He and W atoms. The EOS for the bubbles is fitted to data from MD simulations of He bubbles in bulk W that span a wide range of gas density and sizes up to about 3 nm in diameter. The pressure of subsurface bubbles at the loop punching events as calculated using the bubble-EOS and the volume model agrees well with the pressure obtained directly from the MD simulations. In the loop punching model, for bubbles consisting of [Formula: see text] vacancies and [Formula: see text] helium atoms, the [Formula: see text] ratio that causes the event, the resulting increase in [Formula: see text], and the associated shift of the bubble depth are formulated as a function of [Formula: see text] and T. In the bursting model, a bubble must simultaneously reach a certain depth and [Formula: see text] ratio in order to burst. The burst depth and [Formula: see text] are also modeled as a function of [Formula: see text] and T. The majority of the loop punching events occur at bubble pressures between 20 and 60 GPa, depending on the bubble size and temperature. The larger the bubble and the higher the temperature, the lower the bubble pressure. Furthermore, our results indicate that at a higher temperature, a bubble can burst from a deeper region.

1080. Altered functional brain network patterns in patients with migraine without aura after transcutaneous auricular vagus nerve stimulation.

Sci Rep

2023 Jun 13

Rao Y(#), Liu W(#), Zhu Y

Transcutaneous auricular vagus nerve stimulation (taVNS) shows excellent effects on relieving clinical symptoms in migraine patients. Nevertheless, the neurological mechanisms of taVNS for migraineurs remain unclear. In recent years, voxel-wise degree centrality (DC) and functional connectivity (FC) methods were extensively utilized for exploring alterations in patterns of FC in the resting-state brain. In the present study, thirty-five migraine patients without aura and thirty-eight healthy controls (HCs) were recruited for magnetic resonance imaging scans. Firstly, this study used voxel-wise DC analysis to explore brain regions where abnormalities were present in migraine patients. Secondly, for elucidating neurological mechanisms underlying taVNS in migraine, seed-based resting-state functional connectivity analysis was employed to the taVNS treatment group. Finally, correlation analysis was performed to explore the relationship between alterations in neurological mechanisms and clinical symptoms. Our findings indicated that migraineurs have lower DC values in the inferior temporal gyrus (ITG) and paracentral lobule than in healthy controls (HCs). In addition, migraineurs have higher DC values in the cerebellar lobule VIII and the fusiform gyrus than HCs. Moreover, after taVNS treatment (post-taVNS), patients displayed increased FC between the ITG with the inferior parietal lobule (IPL), orbitofrontal gyrus, angular gyrus, and posterior cingulate gyrus than before taVNS treatment (pre-taVNS). Besides, the post-taVNS patients showed decreased FC between the cerebellar lobule VIII with the supplementary motor area and postcentral gyrus compared with the pre-taVNS patients. The changed FC of ITG-IPL was significantly related to changes in headache intensity. Our study suggested that migraine patients without aura have altered brain connectivity patterns in several hub regions involving multisensory integration, pain perception, and cognitive function. More importantly, taVNS modulated the default mode network and the vestibular cortical network related to the dysfunctions in migraineurs. This paper provides a new perspective on the potential neurological mechanisms and therapeutic targets of taVNS for treating migraine.

1081. Current treatments for endometriosis in South Korea: an analysis of nationwide data from 2010 to 2019.

Sci Rep

2023 Jun 13

Kim HK, Kim ES, Park KS

1082. Use of network pharmacology and molecular docking to explore the mechanism of action of curcuma in the treatment of osteosarcoma.

Sci Rep

2023 Jun 13

Hu M, Yan H, Li H

Curcuma has been used as an adjuvant treatment for osteosarcoma (OS) due to its anticancer compounds. However, the underlying mechanism remains unclear. Therefore, this study aimed to explore the mechanism of action of curcuma in the treatment of OS using network pharmacology and molecular docking. In this study, anticancer compounds were obtained from relevant literature, and curcuma-related targets and OS treatment targets were obtained from public databases. Protein‒protein interaction networks were constructed to screen out the hub genes using the STRING database and Cytoscape software. Cluster analysis of the protein modules was then performed using the Cytoscape MCODE plugin. Furthermore, Gene Ontology enrichment and Kyoto Encyclopedia of Genes and Genomes pathway analyses were performed for common targets among curcuma targets and OS-related targets using the DAVID database. Finally, molecular docking was performed, and the results were verified by Auto dock Tool and PyMOL software. Our research identified 11 potential active compounds, 141 potential therapeutic targets and 14 hub genes for curcuma. AKT1, TNF, STAT3, EGFR, and HSP90AA1 were the key targets closely related to the PI3K/Akt signaling pathways, HIF-1 signaling pathways, ErbB signaling pathways, and FOXO signaling pathways, which are involved in angiogenesis, cancer cell proliferation, metastasis, invasion, and chemotherapy resistance in the microenvironment of OS. Molecular docking suggested that the core compound had a strong affinity for key targets, with a binding energy of less than - 5 kJ/mol. The study showed that curcuma-mediated treatment of OS was a complex process involving multiple compounds, targets, and pathways. This study will enhance the understanding of how curcuma affects the proliferation and invasion of OS cells and reveal the potential molecular mechanism underlying the effect of curcuma on OS lung metastasis and chemotherapy resistance.

1083. D-serine availability modulates prefrontal cortex inhibitory interneuron development and circuit maturation.

Sci Rep

2023 Jun 13

Folorunso OO, Brown SE, Baruah J

1084. Effect of germanium oxide on the structural aspects and bioactivity of bioactive silicate glass.

Sci Rep

2023 Jun 13

Tiama TM, Ibrahim MA, Sharaf MH

1085. Pleobot: a modular robotic solution for metachronal swimming.

Sci Rep

2023 Jun 13

Oliveira Santos S, Tack N, Su Y

1086. A multiscale analysis of heatwaves and urban heat islands in the western U.S. during the summer of 2021.

Sci Rep

2023 Jun 13

Chen K, Boomsma J, Holmes HA.

1087. Running exercise with and without calcium supplementation from tuna bone reduced bone impairment caused by low calcium intake in young adult rats.

Sci Rep

2023 Jun 13

Suntornsaratoon P, Thongklam T, Saetae T

1088. Potential of bacteriophage therapy in managing Staphylococcus aureus infections during chemotherapy for lung cancer patients.

Sci Rep

2023 Jun 12

Li J, Zheng H, Leung SSY.

1089. Pirin is a prognostic marker of human melanoma that dampens the proliferation of malignant cells by downregulating JARID1B/KDM5B expression.

Sci Rep

2023 Jun 12

Penas C, Arroyo-Berdugo Y, Apraiz A

1090. Transcriptome and metabonomics combined analysis revealed the energy supply mechanism involved in fruiting body initiation in Chinese cordyceps.

Sci Rep

2023 Jun 12

He L, Xie F, Zhou G

1091. Development of a portable smart Glucometer with two electrode bio-electronic test strip patch based on Cu/Au/rGO/PEDOT:PSS.

Sci Rep

2023 Jun 12

Monfared Dehbali M, Farahmandpour M, Hamedi S

1092. Effectiveness of one-shot dual-energy subtraction chest radiography with flat-panel detector in distinguishing between calcified and non-calcified nodules.

Sci Rep

2023 Jun 12

Minato K, Yamazaki M, Yagi T

The purpose of this study was to evaluate the added value of the soft tissue image obtained by the one-shot dual-energy subtraction (DES) method using a flat-panel detector compared with the standard image alone in distinguishing calcified from non-calcified nodules on chest radiographs. We evaluated 155 nodules (48 calcified and 107 non-calcified) in 139 patients. Five radiologists (readers 1 - 5) with 26, 14, 8, 6 and 3 years of experience, respectively, evaluated whether the nodules were calcified using chest radiography. CT was used as the gold standard of calcification and non-calcification. Accuracy and area under the receiver operating characteristic curve (AUC) were compared between analyses with and without soft tissue images. The misdiagnosis ratio (false positive plus false negative ratios) when nodules and bones overlapped was also examined. The accuracy of all radiologists increased after adding soft tissue images (readers 1 - 5: 89.7% vs. 92.3% [P = 0.206], 83.2% vs. 87.7% [P = 0.178], 79.4% vs. 92.3% [P < 0.001], 77.4% vs. 87.1% [P = 0.007], and 63.2% vs. 83.2% [P < 0.001], respectively). AUCs for all the readers improved, except for reader 2 (readers 1 - 5: 0.927 vs. 0.937 [P = 0.495], 0.853 vs. 0.834 [P = 0.624], 0.825 vs. 0.878 [P = 0.151], 0.808 vs. 0.896 [P < 0.001], and 0.694 vs. 0.846 [P < 0.001], respectively). The misdiagnosis ratio for nodules that overlapped with the bone decreased after adding soft tissue images in all readers (11.5% vs. 7.6% [P = 0.096], 17.6% vs. 12.2% [P = 0.144], 21.4% vs. 7.6% [P < 0.001], 22.1% vs. 14.5% [P = 0.050] and 35.9% vs. 16.0% [P < 0.001], respectively), particularly that of readers 3 - 5. In conclusion, the soft tissue images obtained using one-shot DES with a flat-panel detector have added value in distinguishing calcified from non-calcified nodules on chest radiographs, especially for less experienced radiologists.

1093. Effect of the association of coagulation/flocculation, hydrodynamic cavitation, ozonation and activated carbon in landfill leachate treatment system.

Sci Rep

2023 Jun 12

de Melo Franco Domingos J, de Alencar Neves T, de Sousa Maia DL

1094. T cell repertoire breadth is associated with the number of acute respiratory infections in the LoewenKIDS birth cohort.

Sci Rep

2023 Jun 12

Paschold L(#), Gottschick C(#), Langer S

1095. Impact of COVID-19 prevention and control on tuberculosis and scarlet fever in China's Guizhou.

Sci Rep

2023 Jun 12

Zhou J, Chen HJ, Lu TJ

1096. Parity and incident type 2 diabetes in older Chinese women: Guangzhou Biobank Cohort Study.

Sci Rep

2023 Jun 12

Su H, Jiang C, Zhang W

1097. Compositional and functional variability of the gut microbiome in children with infantile colic.

Sci Rep

2023 Jun 12

Kozhakhmetov S(#), Meiirmanova Z(#), Mukhanbetzhanov N(#)

1098. Fabricating a dielectrophoretic microfluidic device using 3D-printed moulds and silver conductive paint.

Sci Rep

2023 Jun 12

Valijam S, Nilsson DPG, Malyshev D

1099. Impact of flow regime on the performance of anti-biofouling coatings.

Sci Rep

2023 Jun 12

Pulletikurthi V, Esquivel-Puentes HA, Cheng S

1100. Text information hiding and recovery via wavelet digital watermarking method.

Sci Rep

2023 Jun 12

Xiaohui Z.

1101. Long-term behavioral effects of social separation during early life in a social mammal, Octodon degus.

Sci Rep

2023 Jun 12

Ukyo R, Shinohara A, Koshimoto C

1102. High accuracy distinction of shockable and non-shockable arrhythmias in abnormal classes through wavelet transform with pseudo differential like operators.

Sci Rep

2023 Jun 12

Rahman MM, Albeverio S, Kagawa T

Arrhythmia is an abnormal rhythm of the heart which leads to sudden death. Among these arrhythmias, some are shockable, and some are non-shockable arrhythmias with external defibrillation. The automated external defibrillator (AED) is used as the automated arrhythmia diagnosis system and requires an accurate and rapid decision to increase the survival rate. Therefore, a precise and quick decision by the AED has become essential in improving the survival rate. This paper presents an arrhythmia diagnosis system for the AED by engineering methods and generalized function theories. In the arrhythmia diagnosis system, the proposed wavelet transform with pseudo-differential like operators-based method effectively generates a distinguishable scalogram for the shockable and non-shockable arrhythmia in the abnormal class signals, which leads to the decision algorithm getting the best distinction. Then, a new quality parameter is introduced to get more details by quantizing the statistical features on the scalogram. Finally, design a simple AED shock and non-shock advice method by following this information to improve the precision and rapid decision. Here, an adequate topology (metric function) is adopted to the space of the scatter plot, where we can give different scales to select the best area of the scatter plot for the test sample. As a consequence, the proposed decision method gives the highest accuracy and rapid decision between shockable and non-shockable arrhythmias. The proposed arrhythmia diagnosis system increases the accuracy to 97.98%, with a gain of 11.75% compared to the conventional approach in the abnormal class signals. Therefore, the proposed method contributes an additional 11.75% possibility for increasing the survival rate. The proposed arrhythmia diagnosis system is general and could be applied to distinguish different arrhythmia-based applications. Also, each contribution could be used independently in various applications.

1103. Thrombogenesis-associated genetic determinants as predictors of thromboembolism and prognosis in cervical cancer.

Sci Rep

2023 Jun 12

Neto BV(#), Tavares V(#), da Silva JB

1104. Deforestation for oil palm increases microclimate suitability for the development of the disease vector Aedes albopictus.

Sci Rep

2023 Jun 12

Saager ES, Iwamura T, Jucker T

1105. NISNet3D: three-dimensional nuclear synthesis and instance segmentation for fluorescence microscopy images.

Sci Rep

2023 Jun 12

Wu L, Chen A, Salama P

1106. Analysis of the carbide precipitation and microstructural evolution in HCCI as a function of the heating rate and destabilization temperature.

Sci Rep

2023 Jun 12

Guitar MA, Nayak UP, Campo Schneider L

1107. Low-loss MIMO antenna wireless communication system for 5G cardiac pacemakers.

Sci Rep

2023 Jun 12

Sharma D, Kanaujia BK, Kumar S

1108. Tunable coupling in magnetic thin film heterostructures with a magnetic phase transition.

Sci Rep

2023 Jun 12

Stojak Repa K, Kirby BJ, Miller CW.

1109. Accurate, non-destructive, and high-throughput age estimation for Golden perch (Macquaria ambigua spp.) using DNA methylation.

Sci Rep

2023 Jun 12

Mayne B, Espinoza T, Crook DA

1110. Designing Ising machines with higher order spin interactions and their application in solving combinatorial optimization.

Sci Rep

2023 Jun 12

Bashar MK, Shukla N.

1111. Blood phenylalanine fluctuation in phenylketonuric children treated by BH4 or low-phenylalanine diet from birth.

Sci Rep

2023 Jun 12

Theron M, Jeannesson E, Canton M

1112. Effectual visible light photocatalytic reduction of para-nitro phenol using reduced graphene oxide and ZnO composite.

Sci Rep

2023 Jun 12

Velusamy S(#), Roy A(#), Mariam E

1113. A peptide triple agonist of GLP-1, neuropeptide Y1, and neuropeptide Y2 receptors promotes glycemic control and weight loss.

Sci Rep

2023 Jun 12

Chichura KS(#), Elfers CT(#), Salameh TS

1114. Exposure to polystyrene nanoparticles leads to changes in the zeta potential of bacterial cells.

Sci Rep

2023 Jun 12

Zając M, Kotyńska J, Zambrowski G

1115. Investigation of boron-doped graphene oxide anchored with copper sulphide flowers as visible light active photocatalyst for methylene blue degradation.

Sci Rep

2023 Jun 12

Farhan A, Zahid M, Tahir N

1116. Experimental testing of irradiated engine oil using an e-beam.

Sci Rep

2023 Jun 12

Zachar M, Furch J.

1117. Forecasting of potential anti-inflammatory targets of some immunomodulatory plants and their constituents using in vitro, molecular docking and network pharmacology-based analysis.

Sci Rep

2023 Jun 12

Khairy A, Ghareeb DA, Celik I

1118. Identification of drought-tolerant hub genes in Iranian KC-2226 genotype of Aegilops tauschii using transcriptomic analysis.

Sci Rep

2023 Jun 12

Hasanpour K, Aalami A, Ghanbari Moheb Seraj R

1119. Episodic transient deformation revealed by the analysis of multiple GNSS networks in the Noto Peninsula, central Japan.

Sci Rep

2023 Jun 12

Nishimura T, Hiramatsu Y, Ohta Y.

1120. From MEG to clinical EEG: evaluating a promising non-invasive estimator of defense-related muscle sympathetic nerve inhibition.

Sci Rep

2023 Jun 12

Eskelin JJ, Lundblad LC, Wallin BG

1121. Imagery in the entropic associative memory.

Sci Rep

2023 Jun 12

Pineda LA, Morales R.

1122. Negative phototaxis of jumping cocooned parasitoid wasp larvae against short wavelengths and physicochemical properties of the cocoon shell.

Sci Rep

2023 Jun 12

Iwase SI, Tuda M, Sugawara Y

1123. The effect of carbon price on low carbon innovation.

Sci Rep

2023 Jun 12

Cantone B, Evans D, Reeson A.

1124. Mechanical-induced bone remodeling does not depend on Piezo1 in dentoalveolar hard tissue.

Sci Rep

2023 Jun 12

Nottmeier C, Lavicky J, Gonzalez Lopez M

1125. Improving efficiency of semitransparent organic solar cells by constructing semitransparent microcavity.

Sci Rep

2023 Jun 12

Annabi Milani E, Piralaee M, Asgari A.

1126. Thermal management in annular fin using ternary nanomaterials influenced by magneto-radiative phenomenon and natural convection.

Sci Rep

2023 Jun 12

Alharbi KAM, Adnan, Bani-Fwaz MZ

1127. The WASH-complex subunit Strumpellin regulates integrin αIIbβ3 trafficking in murine platelets.

Sci Rep

2023 Jun 12

Schurr Y(#), Reil L(#), Spindler M(#)

1128. LKC-Net: large kernel convolution object detection network.

Sci Rep

2023 Jun 12

Wang W, Li S, Shao J

1129. Host defense peptides combined with MTA extract increase the repair in dental pulp cells: in vitro and ex vivo study.

Sci Rep

2023 Jun 12

Silva PAO, Martins DCM, de Castro Cantuária AP

1130. Miniaturized Vis-NIR handheld spectrometer for non-invasive pigment quantification in agritech applications.

Sci Rep

2023 Jun 12

Dinish US, Teng MTJ(#), Xinhui VT(#)

1131. Individualized active surveillance for carbapenem-resistant microorganisms using Xpert Carba-R in intensive care units.

Sci Rep

2023 Jun 12

Zhou S(#), Mi S(#), Rao X(#)

1132. Towards optimised extracellular vesicle proteomics from cerebrospinal fluid.

Sci Rep

2023 Jun 12

Kangas P, Nyman TA, Metsähonkala L

1133. Formalin-evoked pain triggers sex-specific behavior and spinal immune response.

Sci Rep

2023 Jun 12

Pepino L, Malapert P, Saurin AJ

1134. Effect of contact number among graphene nanosheets on the conductivities of tunnels and polymer composites.

Sci Rep

2023 Jun 12

Zare Y, Kim TH, Gharib N

1135. Genome-wide genetic variation and molecular surveillance of drug resistance in Plasmodium falciparum isolates from asymptomatic individuals in Ouélessébougou, Mali.

Sci Rep

2023 Jun 12

Vanheer LN, Mahamar A, Manko E

1136. Surface warming from altitudinal and latitudinal amplification over Antarctica since the International Geophysical Year.

Sci Rep

2023 Jun 12

Xie A, Zhu J, Qin X

1137. Lifestyle factors and clinical severity of Parkinson's disease.

Sci Rep

2023 Jun 12

Gabbert C, König IR, Lüth T

1138. The effects of everyday-life social interactions on anxiety-related autonomic responses differ between men and women.

Sci Rep

2023 Jun 12

Gründahl M(#), Weiß M(#), Stenzel K

1139. Factors affecting Hemoglobin A1c in the longitudinal study of the Iranian population using mixed quantile regression.

Sci Rep

2023 Jun 12

Bahrampour A, Haji-Maghsoudi S.

1140. COVID-19 vaccination exacerbates ex vivo IL-6 release from isolated PBMCs.

Sci Rep

2023 Jun 12

Langgartner D, Winkler R, Brunner-Weisser J

Ex vivo culturing of isolated PBMCs from individuals vaccinated with the coronavirus disease 2019 (COVID-19) vaccine BNT162b1 revealed a pronounced T cell response in the presence of the receptor binding domain (RBD) of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein. The latter was 10-fold more pronounced than the ex vivo response of PBMCs from the same individuals to other common pathogen T cell epitope pools, suggesting COVID-19 vaccination to induce RBD-specific T cell responses and not to facilitate T cell (re)activity in general. In the current study we investigated whether COVID-19 vaccination long-lastingly affects plasma interleukin (IL)-6 concentrations, complete blood counts, ex vivo IL-6 and IL-10 secretion of PBMCs cultured under basal conditions or in the presence of concanavalin (Con) A and lipopolysaccharide (LPS), salivary cortisol and α-amylase, mean arterial pressure (MAP), heart rate (HR) as well as mental and physical health status. The study was initially designed to investigate whether the presence vs. absence of own pets during urban upbringing has protective effects against psychosocial stress-induced immune activation during adulthood. However, as COVID-19 vaccines were approved while the study was ongoing and as, therefore, both vaccinated and non-vaccinated individuals have been recruited, we were able to stratify our data set with respect to the COVID-19 vaccination status and to assess the long-lasting effects of COVID-19 vaccination on physiological immunological, cardiovascular and psychosomatic health parameters. This data is presented in the current study. We show that isolated PBMCs from individuals vaccinated against COVID-19 show a ~ 600-fold increase in basal and a ~ 6000-fold increase in ConA-induced proinflammatory IL-6 secretion, and a ~ 2-fold increase in basal and ConA-induced antiinflammatory IL-10 secretion, both in comparison with non-vaccinated individuals. In contrast, LPS-induced ex vivo IL-6 and IL-10 secretions were not affected by vaccination status, as were plasma IL-6 concentrations, complete blood counts, salivary cortisol and α-amylase, cardiovascular measures and psychosomatic health. In summary, our findings are of relevance for many clinical studies ran before/during the pandemic, clearly indicating that consideration of participants' vaccination status is critical, at least when assessing ex vivo PBMC functionality.

1141. Effect of different loads on the shoulder in abduction postures: a finite element analysis.

Sci Rep

2023 Jun 11

Yang Z(#), Xu G(#), Yang J

1142. Flow investigation of the stagnation point flow of micropolar viscoelastic fluid with modified Fourier and Fick's law.

Sci Rep

2023 Jun 11

Naveed Khan M, Abbas Khan A, Wang Z

1143. Identification of novel p-cresol inhibitors that reduce Clostridioides difficile's ability to compete with species of the gut microbiome.

Sci Rep

2023 Jun 11

Harrison MA, Farthing RJ, Allen N

1144. Deep learning-assisted radiomics facilitates multimodal prognostication for personalized treatment strategies in low-grade glioma.

Sci Rep

2023 Jun 11

Rauch P, Stefanits H, Aichholzer M

1145. Comparison of the different anti-CD16 antibody clones in the activation and expansion of peripheral blood NK cells.

Sci Rep

2023 Jun 11

Kim J, Phan MT, Hwang I

1146. Effects of spaceflight on the EEG alpha power and functional connectivity.

Sci Rep

2023 Jun 11

Pusil S(#), Zegarra-Valdivia J(#), Cuesta P

1147. Enhancing heat transfer in solar-powered ships: a study on hybrid nanofluids with carbon nanotubes and their application in parabolic trough solar collectors with electromagnetic controls.

Sci Rep

2023 Jun 10

Obalalu AM, Memon MA, Olayemi OA

1148. Racial and ethnic difference in the risk of fractures in the United States: a systematic review and meta-analysis.

Sci Rep

2023 Jun 10

Bao Y, Xu Y, Li Z

1149. Maternal exposure to benzophenone derivatives and their impacts on offspring's birth outcomes in a Middle Eastern population.

Sci Rep

2023 Jun 10

Teiri H, Samaei MR, Dehghani M

1150. Integrative analysis of hepatic transcriptional profiles reveals genetic regulation of atherosclerosis in hyperlipidemic Diversity Outbred-F1 mice.

Sci Rep

2023 Jun 10

Kim M, Huda MN, Evans LW

Atherogenesis is an insipidus but precipitating process leading to serious consequences of many cardiovascular diseases (CVD). Numerous genetic loci contributing to atherosclerosis have been identified in human genome-wide association studies, but these studies have limitations in the ability to control environmental factors and to decipher cause/effect relationships. To assess the power of hyperlipidemic Diversity Outbred (DO) mice in facilitating quantitative trait loci (QTL) analysis of complex traits, we generated a high-resolution genetic panel of atherosclerosis susceptible (DO-F1) mouse cohort by crossing 200 DO females with C57BL/6J males carrying two human genes: encoding apolipoprotein E3-Leiden and cholesterol ester transfer protein. We examined atherosclerotic traits including plasma lipids and glucose in the 235 female and 226 male progeny before and after 16 weeks of a high-fat/cholesterol diet, and aortic plaque size at 24 weeks. We also assessed the liver transcriptome using RNA-sequencing. Our QTL mapping for atherosclerotic traits identified one previously reported female-specific QTL on Chr10 with a narrower interval of 22.73 to 30.80 Mb, and one novel male-specific QTL at 31.89 to 40.25 Mb on Chr19. Liver transcription levels of several genes within each QTL were highly correlated with the atherogenic traits. A majority of these candidates have already known atherogenic potential in humans and/or mice, but integrative QTL, eQTL, and correlation analyses further pointed Ptprk as a major candidate of the Chr10 QTL, while Pten and Cyp2c67 of the Chr19 QTL in our DO-F1 cohort. Finally, through additional analyses of RNA-seq data we identified genetic regulation of hepatic transcription factors, including Nr1h3, contributes to atherogenesis in this cohort. Thus, an integrative approach using DO-F1 mice effectively validates the influence of genetic factors on atherosclerosis in DO mice and suggests an opportunity to discover therapeutics in the setting of hyperlipidemia.

1151. Study of the mining and aquifer interactions in complex geological conditions and its management.

Sci Rep

2023 Jun 10

Huang W, Sui L, Wang Y

1152. Application of ensemble model in capacity prediction of the CCFST columns under axial and eccentric loading.

Sci Rep

2023 Jun 10

Wang J, Lu R, Cheng M.

1153. First identification of Tyrophagus curvipenis (Acari: Acaridae) and pathogen detection in Apis mellifera colonies in the Republic of Korea.

Sci Rep

2023 Jun 10

Nguyen TT(#), Yoo MS(#), Truong AT(#)

1154. Human skin gas profile of individuals with the people allergic to me phenomenon.

Sci Rep

2023 Jun 10

Sekine Y(#), Oikawa D(#), Todaka M(#).

1155. Simulation study of cone-in-shell target for indirect-drive ion fast ignition concept under the theory of an effective interaction potential.

Sci Rep

2023 Jun 10

Mehrangiz M, Khoshbinfar S.

1156. Investigation of differences in susceptibility of Campylobacter jejuni strains to UV light-emitting diode (UV-LED) technology.

Sci Rep

2023 Jun 10

Soro AB, Ekhlas D, Marmion M

1157. Association of hypertension and insulin resistance in individuals free of diabetes in the ELSA-Brasil cohort.

Sci Rep

2023 Jun 10

Castro L, Brant L, Diniz MF

1158. A single-center experience of over 300 cases of single-incision robotic cholecystectomy comparing the da Vinci SP with the Si/Xi systems.

Sci Rep

2023 Jun 10

Choi YJ(#), Sang NT(#), Jo HS

1159. Determination of ethanol, isopropyl alcohol and methanol in alcohol-based hand sanitiser to ensure product quality, safety and efficacy.

Sci Rep

2023 Jun 10

Nisbar ND, Jamal Khair SK, Bujang NB

The Coronavirus Disease-2019 (COVID-19) outbreak is an unprecedented global pandemic, sparking grave public health emergencies. One of the measures to reduce COVID-19 transmissions recommended by the World Health Organization is hand hygiene, i.e., washing hands with soap and water or disinfecting them using an alcohol-based hand sanitiser (ABHS). Unfortunately, competing ABHSs with unknown quality, safety, and efficacy thrived, posing yet another risk to consumers. This study aims to develop, optimise, and validate a gas chromatography-mass spectrometry (GC-MS)-based analytical method to simultaneously identify and quantify ethanol or isopropyl alcohol as the active ingredient in ABHS, with simultaneous determination of methanol as an impurity. The GC-MS was operated in Electron Ionisation mode, and Selected Ion Monitoring was chosen as the data acquisition method for quantitation. The analytical method was validated for liquid and gel ABHSs, covering the specificity, linearity and range, accuracy, and precisions, including the limit of detection and the limit of quantitation. The specificity of each target analyte was established using the optimised chromatographic separation with unique quantifier and qualifier ions. The linearity was ascertained with a coefficient of determination (r2) of > 0.9994 over the corresponding specification range. Respectively, the accuracy and precisions were satisfactory within 98.99 to 101.09% and < 3.04% of the relative standard deviation. The method was successfully applied to 69 ABHS samples, where 14 contained insufficient amounts of the active ingredient. Alarmingly, four samples comprised a high amount of methanol ranging from 5.3 to 19.4% with respect to the active alcohol percentage, which may pose significant short- and long-term health issues, leading to life-threatening crises for consumers. The method established would benefit in protecting the public against the potential harm due to substandard or unsafe ABHS products, primarily due to the presence of hazardous impurities such as methanol.

1160. The effect of hyperbaric oxygen therapy on myocardial function in post-COVID-19 syndrome patients: a randomized controlled trial.

Sci Rep

2023 Jun 10

Leitman M, Fuchs S, Tyomkin V

1161. Possible seasonal and diurnal modulation of Gammarus pulex (Crustacea, Amphipoda) drift by microsporidian parasites.

Sci Rep

2023 Jun 10

Prati S, Enß J, Grabner DS

1162. Computational fluid dynamics simulation of two-phase flow patterns in a serpentine microfluidic device.

Sci Rep

2023 Jun 10

Amini Y, Ghazanfari V, Heydari M

1163. Anomalous correlation-induced dynamical phase transitions.

Sci Rep

2023 Jun 10

Khan NA, Wang P, Jan M

1164. Relationships between cognitive biases, decision-making, and delusions.

Sci Rep

2023 Jun 10

Sheffield JM, Smith R, Suthaharan P

1165. A correlation of the adsorption capacity of perovskite/biochar composite with the metal ion characteristics.

Sci Rep

2023 Jun 10

Ali SM, El Mansop MA, Galal A

1166. Drivers of sex differences in the South African adult tuberculosis incidence and mortality trends, 1990-2019.

Sci Rep

2023 Jun 10

Kubjane M, Cornell M, Osman M

1167. Enhancing durability and sustainable preservation of Egyptian stone monuments using metabolites produced by Streptomyces exfoliatus.

Sci Rep

2023 Jun 10

Abd-Elhalim BT, Hemdan BA, El-Sayed SM

Despite their threatens for Egyptian stone monuments, A few studies focused on using biocontrol agents against deteriorative fungi and bacteria instead of using chemical assays that leave residuals leading to human toxicity and environmental pollution. This work aims to isolate and identify fungal and bacterial isolates that showed deteriorative activities from stone monuments in Temple of Hathor, Luxor, Egypt, as well as determine the inhibitory activity of metabolites produced by Streptomyces exfoliatus SAMAH 2021 against the identified deteriorative fungal and bacterial strains. Moreover, studying the spectral analysis, toxicological assessment of metabolites produced by S. exfoliatus SAMAH 2021 against health human cell fibroblast, and colorimetric measurements on the selected stone monuments. Ten samples were collected from Temple of Hathor, Luxor, Egypt. Three fungal isolates and one bacterial isolate were obtained and identified as A. niger isolate Hathor 2, C. fioriniae strain Hathor 3, P. chrysogenum strain HATHOR 1, and L. sphaericus strain Hathor 4, respectively. Inhibitory potential of the metabolites in all concentrations used (100-25%) against the recommended antibiotics (Tetracycline 10 µg/ml and Doxycycline (30 µg/ml) showed an inhibitory effect toward all tested deteriorative pathogens with a minimum inhibition concentration (MIC) of 25%. Cytotoxicity test confirmed that microbial filtrate as the antimicrobial agent was safe for healthy human skin fibroblast with IC50 of < 100% and cell viability of 97%. Gas chromatography analysis recorded the existence of thirteen antimicrobial agents, Cis-vaccenic acid; 1,2-Benzenedicarboxylic acid; ç-Butyl-ç-butyrolactone and other compounds. Colorimetric measurements confirmed no color or surface change for the limestone-treated pieces. The use of the metabolite of microbial species antimicrobial as a biocontrol agent raises contemporary issues concerning the bio-protection of the Egyptian monuments to reduce chemical formulas that are toxic to humans and pollute the environment. Such serious problems need further investigation for all kinds of monuments.

1168. Influence of slope angle on deposit morphology and propagation of laboratory landslides.

Sci Rep

2023 Jun 10

Wu YB, Duan Z, Peng JB

1169. Fuzzy random evaluation of creep model of frozen soft soil in metro tunnel construction using artificial ground freezing technique.

Sci Rep

2023 Jun 10

Yao Y, Zhu Y, Shen D

1170. Identification, isolation, and structural characterization of novel forced degradation products of Ertugliflozin using advanced analytical techniques.

Sci Rep

2023 Jun 10

Salakolusu S, Katari NK, Sharma GVR

1171. Anatomy of nanomagnetic switching at a 3D topological insulator PN junction.

Sci Rep

2023 Jun 10

Xie Y, Vakili H, Ganguly S

1172. Comparative analysis between operative and non-operative acetabular labral tear injuries in division 1 collegiate athletes.

Sci Rep

2023 Jun 10

Hyland SS Jr, Maeso AD, Rogers M

1173. Major and minor ECG abnormalities depending on regional living conditions in Russia.

Sci Rep

2023 Jun 1

Maksimov S, Muromtseva G, Kutsenko V

1174. Identification of genetic loci associated with renal dysfunction after lung transplantation using an ethnic-specific single-nucleotide polymorphism array.

Sci Rep

2023 Jun 1

Tomioka Y, Sugimoto S, Yamamoto H

1175. GIS-based hydrodynamic modeling for urban flood mitigation in fast-growing regions: a case study of Erbil, Kurdistan Region of Iraq.

Sci Rep

2023 Jun 1

Mustafa A, Szydłowski M, Veysipanah M

1176. Combination of genetically diverse Pseudomonas phages enhances the cocktail efficiency against bacteria.

Sci Rep

2023 Jun 1

Naknaen A, Samernate T, Wannasrichan W

1177. The risk of colorectal cancer according to obesity status at four-year intervals: a nationwide population-based cohort study.

Sci Rep

2023 Jun 1

Seo JY, Jin EH, Chung GE

1178. Mining belt foreign body detection method based on YOLOv4_GECA model.

Sci Rep

2023 Jun 1

Xiao D, Liu P, Wang J

1179. Association of citrullination with the progression of aortic stenosis.

Sci Rep

2023 Jun 1

Kim AR(#), Ji E(#), Lee S

1180. Maternal and/or post-weaning supplementation with Bacillus altitudinis spores modulates the microbial composition of colostrum, digesta and faeces in pigs.

Sci Rep

2023 Jun 1

Rattigan R, Lawlor PG, Cormican P

1181. Part two: an unblinded, parallel, randomized study to assess nicotine pharmacokinetics of four Vuse Solo ENDS flavors in smokers.

Sci Rep

2023 Jun 1

Keyser BM, Hong KS, DeLuca P

1182. Evaluation of SARS-CoV-2 isolation in cell culture from nasal/nasopharyngeal swabs or saliva specimens of patients with COVID-19.

Sci Rep

2023 Jun 1

Yazawa S, Yamazaki E, Saga Y

1183. Atlas-based finite element analyses with simpler constitutive models predict personalized progression of knee osteoarthritis: data from the osteoarthritis initiative.

Sci Rep

2023 Jun 1

Mononen ME, Paz A, Liukkonen MK

New technologies are required to support a radical shift towards preventive healthcare. Here we focus on evaluating the possibility of finite element (FE) analysis-aided prevention of knee osteoarthritis (OA), a disease that affects 100 million citizens in the US and EU and this number is estimated to increase drastically. Current clinical methods to diagnose or predict joint health status relies on symptoms and tissue failures obtained from clinical imaging. In a joint with no detectable injuries, the diagnosis of the future health of the knee can be assumed to be very subjective. Quantitative approaches are therefore needed to assess the personalized risk for the onset and development of knee OA. FE analysis utilizing an atlas-based modeling approach has shown a preliminary capability for simulating subject-specific cartilage mechanical responses. However, it has been verified with a very limited subject number. Thus, the aim of this study is to verify the real capability of the atlas-based approach to simulate cartilage degeneration utilizing different material descriptions for cartilage. A fibril reinforced poroviscoelastic (FRPVE) material formulation was considered as state-of-the-art material behavior, since it has been preliminary validated against real clinical follow-up data. Simulated mechanical tissue responses and predicted cartilage degenerations within knee joint with FRPVE material were compared against simpler constitutive models for cartilage. The capability of the atlas-based modeling to offer a feasible approach with quantitative evaluation for the risk for the OA development (healthy vs osteoarthritic knee, p < 0.01, AUC ~ 0.7) was verified with 214 knees. Furthermore, the results suggest that accuracy for simulation of cartilage degeneration with simpler material models is similar to models using FPRVE materials if the material parameters are chosen properly.

1184. The effect of the COVID-19 pandemic on life expectancy in 27 countries.

Sci Rep

2023 Jun 1

Huang G, Guo F, Zimmermann KF

1185. Implication of the micro- and lithofacies types on the quality of a gas-bearing deltaic reservoir in the Nile Delta, Egypt.

Sci Rep

2023 Jun 1

Nabawy BS, Abd El Aziz EA, Ramadan M

The Messinian Qawasim sequence, as one of the most important reservoirs in the Egyptian Nile Delta, represents a typical gas-bearing deltaic reservoir sequence. It aims at delineating the implication of the litho- and microfacies associations on the reservoir characteristics of the different stages of the fluvial deltas including the prodelta, proximal/distal delta front, and the delta plain depositional sequences. The studied reservoir sequence was divided into two units; upper and lower clastic units. The petrophysical properties of these two units were studied on the borehole scale using the gamma-ray, caliper, sonic, density, neutron, and resistivity logs to estimate the reservoir parameters including the total and effective porosities, water saturation, shale volume, and the net-pay thickness. For more details, they are also examined on the plug-scale using the core dataset including helium porosity, density, permeability, and fluids saturations, where the flow zone indicator, the reservoir potentiality index, the reservoir quality index, and the average reservoir pore radius were then estimated. The entire sequence is divided into five reservoir rock types (RRT1-RRT5) where, the best quality is assigned to the first RRT (the upper reservoir unit), and the lowest quality is assigned to the RRT5 of the lower reservoir unit. Based on core description and the petrographical studies five lithofacies and four microfacies have been identified. The lithofacies are (1) laminated mudstones/siltstones, (2) ripple laminated sandstones, (3) cross-laminated sandstones, (4) cross-bedded sandstones, and (5) pebbly massive sandstones. These lithofacies are primarily composed of four microfacies; sublithic arenites, subarkose arenite, glauconitic quartz wacke, and sandy mudstone/siltstone. Based on this study, the pebbly massive and the cross-bedded sandstones of the upper unit which is composed of the sublithic and subarkose arenites (RRT1-RRT2) have the best reservoir quality. On the other hand, the lowest quality is assigned to the RRT5 (sandy mudstone/siltstone microfacies) which is represented on the macro scale by the laminated mudstones/siltstones lithofacies. The integration between multi-scale datasets (core-well, petrography, well logs, and seismic) gives a precise picture of the deltaic Qawasim reservoir rock units in the Nile Delta. This workflow has never been applied to the deltaic system in the onshore Nile delta and North Africa. Thereby, this study is considered a standard case study for the deltaic sequences and its proposed workflow is applicable to the Nile Delta elsewhere and worldwide for similar reservoir sequences.

1186. Worn surface topography and mathematical modeling of Ti-6Al-3Mo-2Sn-2Zr-2Nb-1.5Cr alloy.

Sci Rep

2023 Jun 1

Elshaer RN, Ibrahim KM, Farahat AIZ.

This study aims at investigating worn surface topography and mathematical modeling of annealed Ti-6Al-3Mo-2Sn-2Zr-2Nb-1.5Cr alloy using response surface methodology (RSM). The alloy was subjected to three different regimes in order to study their effect on mechanical properties. First regime was applying cold deformation by compression until 15% drop in height at room temperature. The second regime was performing solution treated on the deformed samples at 920 °C for 15 min then air-cooled (AC) to ambient temperature. Third regime was applying aging on the deformed and solution treated specimen for 4 hr at 590 °C followed by air-cooling. Three different velocities (1, 1.5, and 2 m/s) were adopted to conduct dry sliding wear according to the experimental design technique (EDT). Gwyddion and Matlab softwares were used to detect worn surface photographs analytically and graphically. Maximum hardness of 425 HV20 was obtained for AC+Aging specimen, while minimum hardness of 353 HV20 was reported for the annealed specimen. Applying aging process after solution treatment enhanced considerably the wear property and this enhancement reached 98% as compared to the annealed condition. The relationship between input factors (hardness & velocity) and responses (Abbott Firestone zones) was demonstrated using analysis of variance (ANOVA). The best models for Abbott Firestone zones (high peaks, exploitation, and voids) produced accurate data that could be estimated for saving time and cost. The results showed that the average surface roughness increases with increasing sliding velocity for all conditions except AC+Aging condition where the average surface roughness decreased with increasing sliding velocity. The results revealed that at low velocity and hardness, the material gives the highest exploitation zone (86%). While at high velocity and hardness, the material gives the lowest exploitation zone (70%). In general, the predicted results of mathematical model showed close agreement with experimental results, creating that models could be utilized to predict Abbott Firestone zones satisfactorily.

1187. Simultaneous imaging of ultrasonic relative backscatter and attenuation coefficients for quantitative liver steatosis assessment.

Sci Rep

2023 Jun 1

Timaná J(#), Chahuara H, Basavarajappa L

1188. The prognostic value of URR equals that of Kt/V for all-cause mortality in Taiwan after 10-year follow-up.

Sci Rep

2023 Jun 1

Chen YK, Chu CS, Niu SW

1189. Evaluation of epigenetic methylation biomarkers for the detection of colorectal cancer using droplet digital PCR.

Sci Rep

2023 Jun 1

Petit J(#), Carroll G(#), Zhao J(#)

1190. Factors associated with frequent high-cost individuals with cystic fibrosis and their healthcare utilization and cost patterns.

Sci Rep

2023 Jun 1

Desai S, Zhang W, Sutherland JM

1191. CD36 relative mean fluorescence intensity of CD105(+) nucleated erythroid cells can be used to differentiate myelodysplastic syndrome from megaloblastic anemia.

Sci Rep

2023 Jun 1

Lu Y, Chen X, Zhang L.

1192. Non-target GC-MS analyses of fecal VOCs in NASH-hepatocellular carcinoma model STAM mice.

Sci Rep

2023 Jun 1

Kato M(#), Yamaguchi M(#), Ooka A

1193. Morpho-physiological responses and growth indices of triticale to drought and salt stresses.

Sci Rep

2023 Jun 1

Mohammadi Alagoz S, Hadi H, Toorchi M

Salinity and drought are two major abiotic stresses challenging global crop production and food security. In this study, the effects of individual and combined effects of drought (at different phenological stages) and salt stresses on growth, morphology, and physiology of triticale were evaluated. For this purpose, a 3 x 4 factorial design in three blocks experiment was conducted. The stress treatments included three levels of salinity (0, 50, and 100 mM NaCl) and four levels of drought (regular irrigation as well as irrigation disruption at heading, flowering, and kernel extension stages). The stresses, individual as well as combined, caused a significant decrease in chlorophyll contents, total dry matter, leaf area index, relative water content, and grain yield of triticale. In this regard, the highest reduction was recorded under combined stresses of 100 mM NaCl and drought stress at flowering. However, an increase in soluble sugars, leaf free proline, carotenoid contents, and electrolyte leakage was noted under stress conditions compared to the control. In this regard, the highest increase in leaf free proline, soluble sugars, and carotenoid contents were noted under the combination of severe salinity and drought stress imposed at the flowering stage. Investigating the growth indices in severe salinity and water deficit stress in different phenological stages shows the predominance of ionic stress over osmotic stress under severe salinity. The highest grain yield was observed under non-saline well-watered conditions whereas the lowest grain yield was recorded under severe salinity and drought stress imposed at the flowering stage. In conclusion, the flowering stage was more sensitive than the heading and kernel extension stages in terms of water deficit. The impact of salinity and water deficit was more pronounced on soluble sugars and leaf free proline; so, these criteria can be used as physiological indicators for drought and salinity tolerance in triticale.

1194. Discovery of the allosteric inhibitor from actinomyces metabolites to target EGFR(CSTMLR) mutant protein: molecular modeling and free energy approach.

Sci Rep

2023 Jun 1

Saini R, Kumari S, Bhatnagar A

EGFR (epidermal growth factor receptor), a surface protein on the cell, belongs to the tyrosine kinase family, responsible for cell growth and proliferation. Overexpression or mutation in the EGFR gene leads to various types of cancer, i.e., non-small cell lung cancer, breast, and pancreatic cancer. Bioactive molecules identified in this genre were also an essential source of encouragement for researchers who accomplished the design and synthesis of novel compounds with anticancer properties. World Health Organization (WHO) report states that antibiotic resistance is one of the most severe risks to global well-being, food safety, and development. The world needs to take steps to lessen this danger, such as developing new antibiotics and regulating their use. In this study, 6524 compounds derived from Streptomyces sp. were subjected to drug-likeness filters, molecular docking, and molecular dynamic simulation for 1000 ns to find new triple mutant EGFRCSTMLR (EGFR-L858R/T790M/C797S) inhibitors. Docking outcomes revealed that five compounds showed better binding affinity (- 9.074 to - 9.3 kcal/mol) than both reference drug CH7233163 (- 6.11 kcal/mol) and co-crystallized ligand Osimertinib (- 8.07 kcal/mol). Further, molecular dynamic simulation confirmed that ligand C_42 exhibited the best interaction at the active site of EGFR protein and comprised a better average radius of gyration (3.87 Å) and average SASA (Solvent Accessible Surface Area) (82.91 Å2) value than co-crystallized ligand (4.49 Å, 222.38 Å2). Additionally, its average RMSD (Root Mean Square Deviation) (3.25 Å) and RMSF (Root Mean Square Fluctuation) (1.54 Å) values were highly similar to co-crystallized ligand (3.07 Å, 1.54 Å). Compared to the reference ligand, it also demonstrated conserved H-bond interactions with the residues MET_793 and GLN_791 with strong interaction probability. In conclusion, we have found a potential drug with no violation of the rule of three, Lipinski's rule of five, and 26 other vital parameters having great potential in medicinal and pharmaceutical industries applications and can overcome synthetic drug issues.

1195. Spatiotemporal evolution characteristics and prediction analysis of urban air quality in China.

Sci Rep

2023 Jun 1

Du Y, You S, Liu W

1196. First-principles density functional theoretical study on the structures, reactivity and spectroscopic properties of (NH) and (OH) Tautomer's of 4-(methylsulfanyl)-3[(1Z)-1-(2-phenylhydrazinylidene) ethyl] quinoline-2(1H)-one.

Sci Rep

2023 Jun 1

Halim SA, Abdel-Rahman MA.

1197. Gut microbiota-derived lipid metabolites facilitate regulatory T cell differentiation.

Sci Rep

2023 Jun 1

Shiratori H(#), Oguchi H(#), Isobe Y(#)

1198. The efficacy of biosynthesized silver nanoparticles against Pseudomonas aeruginosa isolates from cystic fibrosis patients.

Sci Rep

2023 Jun 1

Al-Momani H, Almasri M, Al Balawi D

The high antibiotic resistance of Pseudomonas aeruginosa (PA) makes it critical to develop alternative antimicrobial agents that are effective and affordable. One of the many applications of silver nanoparticles (Ag NPs) is their use as an antimicrobial agent against bacteria resistant to common antibiotics. The key purpose of this research was to assess the antibacterial and antibiofilm effectiveness of biosynthesized Ag NPs against six biofilm-forming clinically isolated strains of PA and one reference strain (ATCC 27853). Ag NPs were biosynthesized using a seed extract of Peganum harmala as a reducing agent. Ag NPs were characterized by Ultraviolet-visible (UV-Vis) spectroscopy and scanning transmission electron microscopy (STEM). The effect of Ag NPs on biofilm formation and eradication was examined through micro-titer plate assays, and the minimal inhibitory (MIC) and minimum bactericidal (MBC) concentrations determined. In addition, real-time polymerase chain reactions (RT-PCR) were performed to examine the effects of Ag NPs on the expression of seven PA biofilm-encoding genes (LasR, LasI, LssB, rhIR, rhII, pqsA and pqsR). The biosynthesized Ag NPs were spherically-shaped with a mean diameter of 11 nm. The MIC for each PA strain was 15.6 µg/ml, while the MBC was 31.25 µg/ml. All PA strains exposed to Ag NPs at sub-inhibitory concentrations (0.22-7.5 µg/ml) showed significant inhibitory effects on growth and biofilm formation. Biomass and biofilm metabolism were reduced dependent on Ag NP concentration. The expression of the quorum-sensing genes of all strains were significantly reduced at an Ag NP concentration of 7.5 µg/ml. The results demonstrate the extensive in-vitro antibacterial and antibiofilm performance of Ag NPs and their potential in the treatment of PA infection. It is recommended that future studies examine the possible synergy between Ag NPs and antibiotics.

1199. Sources of contamination in sediments of retention tanks and the influence of precipitation type on the size of pollution load.

Sci Rep

2023 Jun 1

Matej-Łukowicz K, Wojciechowska E, Kolerski T

1200. Exosomes with overexpressed miR 147a suppress angiogenesis and infammatory injury in an experimental model of atopic dermatitis.

Sci Rep

2023 Jun 1

Shi C, Pei S, Ding Y

Atopic dermatitis is defined as an intensely systemic inflammation among skin diseases. Exosomes derived from adipose-derived stem cells may be a novel cell-free therapeutic strategy for atopic dermatitis treatment. This study aims to elucidate the possible underlying mechanism of adipose-derived stem cells-exosomes harboring microRNA-147a in atopic dermatitis pathogenesis. BALB/c mice treated with Dermatophagoides farinae extract/2,4-dinitrochlorobenzene were defined as a mouse model of atopic dermatitis, either with inflamed HaCaT cells and HUVECs exposed with TNF-α/IFN-γ stimulation were applied for a cell model of atopic dermatitis. The concentrations of IL-1β and TNF-α in the supernatants were examined by ELISA. Cell viability and migration were assessed by MTT and Transwell assay. The apoptosis was examined using flow cytometry and TUNEL staining. The tube formation assay was employed to analyzed angiogenesis. The molecular regulations among miR-147a, MEF2A, TSLP and VEGFA were confirmed using luciferase reporter assay, either with ChIP. microRNA-147a was markedly downregulated in the serum and skin samples of atopic dermatitis mice, of which overexpression remarkably promoted HaCaT cell proliferation, meanwhile inhibiting inflammatory response and cell apoptosis. microRNA-147a in adipose-derived stem cells was subsequently overexpressed, and exosomes (Exos-miR-147a mimics) were collected. Functionally, exos-microRNA-147a mimics attenuated TNF-α/IFN-γ-induced HaCaT cell inflammatory response and apoptosis, and suppressed HUVECs angiogenesis. Encouraging, molecular interaction experiments revealed that exosomal microRNA-147a suppressed TNF-α/IFN-γ-induced HUVECs angiogenesis by targeting VEGFA, and exosomal microRNA-147a repressed HaCaT cells inflammatory injury through the MEF2A-TSLP axis. Mechanistically, exosomal microRNA-147a repressed pathological angiogenesis and inflammatory injury during atopic dermatitis progression by targeting VEGFA and MEF2A-TSLP axis. microRNA-147a-overexpressing adipose-derived stem cells-derived exosomes suppressed pathological angiogenesis and inflammatory injury in atopic dermatitis by targeting VEGFA and MEF2A-TSLP axis.

1201. An integrative approach to understanding diversity patterns and assemblage rules in Neotropical bats.

Sci Rep

2023 Jun 1

Hurtado-Materon MA, Murillo-García OE.

1202. Electromagnetic deactivation spectroscopy of human coronavirus 229E.

Sci Rep

2023 Jun 1

Banting H, Goode I, Flores CEG

1203. Heterogeneity of voltage gated sodium current density between neurons decorrelates spiking and suppresses network synchronization in Scn1b null mouse models.

Sci Rep

2023 Jun 1

Hull JM, Denomme N, Yuan Y

1204. Optimizing gamma radiation shielding with cobalt-titania hybrid nanomaterials.

Sci Rep

2023 Jun 1

Alhindawy IG, Sayyed MI, Almuqrin AH

1205. Identification and genetic diversity analysis of high-yielding charcoal rot resistant soybean genotypes.

Sci Rep

2023 Jun 1

Amrate PK, Shrivastava MK, Bhale MS

1206. Polyproline type II helical antifreeze proteins are widespread in Collembola and likely originated over 400 million years ago in the Ordovician Period.

Sci Rep

2023 Jun 1

Scholl CL, Holmstrup M, Graham LA

1207. A tile model of circuit topology for self-entangled biopolymers.

Sci Rep

2023 Jun 1

Flapan E(#), Mashaghi A, Wong H(#).

1208. Influence of jump height on the game efficiency in elite volleyball players.

Sci Rep

2023 Jun 1

Pawlik D, Mroczek D.

1209. On the thermodynamics of DNA methylation process.

Sci Rep

2023 Jun 1

Sanchez R, Mackenzie SA.

1210. Detecting introgressive hybridization to maintain genetic integrity in endangered large waterbird: a case study in milky stork.

Sci Rep

2023 Jun 1

Kaminsin D, Warrit N, Sankhom R

1211. Multiscale assessment of habitat selection and avoidance of sympatric carnivores by the endangered ocelot.

Sci Rep

2023 Jun 1

Sergeyev M, Cherry MJ, Tanner EP

Habitat selection by animals is a complex, dynamic process that can vary across spatial and temporal scales. Understanding habitat selection is a vital component of managing endangered species. Ocelots (Leopardus pardalis), a medium-sized endangered felid, overlap in their northern range with bobcats (Lynx rufus) and coyotes (Canis latrans), with all three species sharing similar space and resource use. As the potential for competition between these three carnivores is high, understanding differences in habitat use and the effect of these potential competitors on habitat selection of ocelots is essential to conservation. Our objective was to compare habitat selection between species and examine if ocelots avoided areas used by competitors at broad and fine scales. We captured and collared 8 ocelots, 13 bobcats, and 5 coyotes on the East Foundation's El Sauz Ranch and the Yturria San Francisco Ranch in South Texas, USA from 2017 to 2021. We compared 2nd (position of home range) and 3rd (use within the home range) order selection across species and examined whether ocelots avoided areas categorized as high probability of use by bobcats and coyotes across both orders of selection. We found a preference for heterogeneous landscapes by bobcats and coyotes while ocelots were strongly tied to woody cover across both orders. At the 2nd order, ocelots selected areas with higher probability of use by bobcats and showed no response to higher probability of use by coyotes, suggesting ocelots did not avoid either species. However, at the 3rd order, ocelots avoided areas used by coyotes. Ocelots selected for areas of use by bobcats at the 2nd order and 3rd order. Results suggest that at the broader scale, placement of the home range is not affected by the presence of sympatric carnivores, however, at a finer scale, ocelots are avoiding coyotes but not bobcats. Our study emphasizes the importance of woody and herbaceous cover at the broad scale and dense vegetation at the finer scale to sustain ocelots. In addition, we show differing patterns of interspecific avoidance by ocelots across species and scales.

1212. Genomic and molecular landscape of homologous recombination deficiency across multiple cancer types.

Sci Rep

2023 Jun 1

Shi Z(#), Chen B(#), Han X(#)

1213. 3D modelling and simulation of the impact of wearing a mask on the dispersion of particles carrying the SARS-CoV-2 virus in a railway transport coach.

Sci Rep

2023 Jun 1

Armand P, Tâche J.

Even though the Covid-19 pandemic seems to be stagnating or decreasing across the world, a resurgence of the disease or the occurrence of other epidemics caused by the aerial dissemination of pathogenic biological agents cannot be ruled out. These agents, in particular the virions of the Covid-19 disease, are found in the particles originating from the sputum of infected symptomatic or asymptomatic people. In previous research, we made use of a three-dimensional Computational Fluid Dynamics (CFD) model to simulate particle transport and dispersion in ventilated semi-confined spaces. By way of illustration, we considered a commuter train coach in which an infected passenger emitted droplets (1 and 10 µm) and drops (100 and 1000 µm) while breathing and coughing. Using an Eulerian approach and a Lagrangian approach, we modelled the dispersion of the particles in the turbulent flow generated by the ventilation of the coach. The simulations returned similar results from both approaches and clearly demonstrated the very distinct aerodynamics of the aerosol of airborne droplets and, at the other end of the spectrum, of drops falling or behaving like projectiles depending on their initial velocity. That numerical study considered passengers without protective masks. In this new phase of research, we first used literature data to develop a model of a typical surgical mask for use on a digital manikin representing a human. Next, we resumed the twin experiment of the railway coach, but this time, the passengers (including the infected one) were provided with surgical masks. We compared the spatial and temporal distributions of the particles depending on whether the spreader passenger wore a mask at all, and whether the mask was perfectly fitted (without leaks) or worn loosely (with leaks). Beyond demonstrating the obvious value of wearing a mask in limiting the dissemination of particles, our model and our simulations allow a quantification of the ratio of particles suspended in the coach depending on whether the infected passenger wears a mask or not. Moreover, the calculations carried out constitute only one illustrative application among many others, not only in public transport, but in any other public or private ventilated space on the basis of the same physical models and digital twins of the places considered. CFD therefore makes it possible to estimate the criticality of the occupation of places by people with or without a mask and to recommend measures in order to limit aerial contamination by any kind of airborne pathogen, such as the virions of Covid-19.

1214. Physical and chemical characterization of smokeless tobacco products in India.

Sci Rep

2023 Jun 1

Sharma P, Cheah NP, Kaur J

Newmer生物

Newmer生物