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Sci Rep

2023 Feb 8

Seo J, Raeymaekers B.

2. Description of allergic phenotype in patients with eosinophilic oesophagitis: management protocol proposal.

Sci Rep

2023 Feb 8

Domenech Witek J, Gonzalez Mendiola R, Jover Cerdá V

3. Breaking the hard-sphere model with fluorite and antifluorite solid solutions.

Sci Rep

2023 Feb 8

Vauchy R, Hirooka S, Watanabe M

4. Effects of cottonseed hull on intake, digestibility, nitrogen balance, blood metabolites and ingestive behaviour of rams.

Sci Rep

2023 Feb 8

Zanine AM, Castro WJR, Ferreira DJ

5. Limbic progesterone receptors regulate spatial memory.

Sci Rep

2023 Feb 7

Joshi S, Williams CL, Kapur J.

6. Identifying congenital generalized lipodystrophy using deep learning-DEEPLIPO.

Sci Rep

2023 Feb 7

da Cunha Olegario NB, da Cunha Neto JS, Barbosa PCS

Congenital Generalized Lipodystrophy (CGL) is a rare autosomal recessive disease characterized by near complete absence of functional adipose tissue from birth. CGL diagnosis can be based on clinical data including acromegaloid features, acanthosis nigricans, reduction of total body fat, muscular hypertrophy, and protrusion of the umbilical scar. The identification and knowledge of CGL by the health care professionals is crucial once it is associated with severe and precocious cardiometabolic complications and poor outcome. Image processing by deep learning algorithms have been implemented in medicine and the application into routine clinical practice is feasible. Therefore, the aim of this study was to identify congenital generalized lipodystrophy phenotype using deep learning. A deep learning approach model using convolutional neural network was presented as a detailed experiment with evaluation steps undertaken to test the effectiveness. These experiments were based on CGL patient's photography database. The dataset consists of two main categories (training and testing) and three subcategories containing photos of patients with CGL, individuals with malnutrition and eutrophic individuals with athletic build. A total of 337 images of individuals of different ages, children and adults were carefully chosen from internet open access database and photographic records of stored images of medical records of a reference center for inherited lipodystrophies. For validation, the dataset was partitioned into four parts, keeping the same proportion of the three subcategories in each part. The fourfold cross-validation technique was applied, using 75% (3 parts) of the data as training and 25% (1 part) as a test. Following the technique, four tests were performed, changing the parts that were used as training and testing until each part was used exactly once as validation data. As a result, a mean accuracy, sensitivity, and specificity were obtained with values of [90.85 ± 2.20%], [90.63 ± 3.53%] and [91.41 ± 1.10%], respectively. In conclusion, this study presented for the first time a deep learning model able to identify congenital generalized lipodystrophy phenotype with excellent accuracy, sensitivity and specificity, possibly being a strategic tool for detecting this disease.

7. Skin irritation in children undergoing orthodontic facemask therapy.

Sci Rep

2023 Feb 7

Kim H(#), Kim JS(#), Kim CS

8. Modeling acute care utilization: practical implications for insomnia patients.

Sci Rep

2023 Feb 7

Chekani F, Zhu Z, Khandker RK

9. Benefits of the microalgae Spirulina and Schizochytrium in fish nutrition: a meta-analysis.

Sci Rep

2023 Feb 7

Trevi S, Uren Webster T, Consuegra S

10. Co-cultivation of Mortierellaceae with Pseudomonas helmanticensis affects both their growth and volatilome.

Sci Rep

2023 Feb 7

Probst M(#), Telagathoti A(#), Siewert B

11. Magnetic hydrogel particles improve nanopore sequencing of SARS-CoV-2 and other respiratory viruses.

Sci Rep

2023 Feb 7

Andersen P, Barksdale S, Barclay RA

12. Inactivation kinetics of 280 nm UV-LEDs against Mycobacterium abscessus in water.

Sci Rep

2023 Feb 7

Song JJX, Oguma K, Takizawa S.

13. Gut microbiota of Parkinson's disease in an appendectomy cohort: a preliminary study.

Sci Rep

2023 Feb 7

Nakahara K(#), Nakane S(#), Ishii K

14. A single point mutation expands the applicability of ostreolysin A6 in biomedicine.

Sci Rep

2023 Feb 7

Panevska A, Čegovnik N, Fortuna K

15. Rare variant aggregation in 148,508 exomes identifies genes associated with proxy dementia.

Sci Rep

2023 Feb 7

Wightman DP, Savage JE, de Leeuw CA

16. Mechanisms of amyloid-β34 generation indicate a pivotal role for BACE1 in amyloid homeostasis.

Sci Rep

2023 Feb 7

Ulku I, Liebsch F, Akerman SC

17. Upwelling, climate change, and the shifting geography of coral reef development.

Sci Rep

2023 Feb 7

Rodriguez-Ruano V, Toth LT, Enochs IC

18. Room-temperature spin injection from a ferromagnetic semiconductor.

Sci Rep

2023 Feb 7

Goel S, Khang NHD, Osada Y

19. Risk factors and prognosis of postoperative delirium in nonagenarians with hip fracture.

Sci Rep

2023 Feb 7

Zhao S, Sun T, Zhang J

20. Calibration of spectra in presence of non-stationary background using unsupervised physics-informed deep learning.

Sci Rep

2023 Feb 7

Puleio A, Rossi R, Gaudio P.

21. In silico drug discovery of SIRT2 inhibitors from natural source as anticancer agents.

Sci Rep

2023 Feb 7

Ibrahim MAA, Abdeljawaad KAA, Roshdy E

22. Human cochlear microstructures at risk of electrode insertion trauma, elucidated in 3D with contrast-enhanced microCT.

Sci Rep

2023 Feb 7

Starovoyt A, Pyka G, Putzeys T

23. Epidemiological and genomic analysis of dengue cases in Guangzhou, China, from 2010 to 2019.

Sci Rep

2023 Feb 7

Jiang L(#), Liu Y(#), Su W(#)

24. Effects of different remote ischemia perconditioning methods on cerebral infarct volume and neurological impairment in rats.

Sci Rep

2023 Feb 7

Otsuka S(#), Itashiki Y(#), Tani A

25. The effects of core stabilization exercises on the neuromuscular function of athletes with ACL reconstruction.

Sci Rep

2023 Feb 7

Saki F, Shafiee H, Tahayori B

Athletes who have undergone anterior cruciate ligament reconstruction (ACLR) often exhibit persistently impaired kinematics and strength. Core stability training appears to be effective for reducing high-risk landing mechanics and preventing primary anterior cruciate ligament (ACL) injuries; however, there have been few attempts to examine their effects in athletes who have undergone ACLR. This study aimed to investigate the effect of eight weeks of simple core stability training on core endurance, hip strength, and knee kinematics in ACLR athletes. Twenty-six male athletes (20-30 years old) with a history of ACL surgery with hamstring tendon autograft were randomly divided into training (n = 13) and control groups (n = 13). The training group performed core stability exercises for eight weeks before starting their team training; the control group did not receive any intervention. Both groups continued their regular team schedule. The core endurance, hip muscle strength, and knee kinematics were assessed by the McGill test, a hand-held dynamometer, and video-taping, respectively. Analysis of covariance test was used for data analysis. The training group showed a significant increase in core endurance, hip abductor and external rotator strength, knee flexion angle, and a significant decrease in the knee valgus angle during single-leg landing in post-training tests compared to their baseline tests (P < 0.05). Our results demonstrated that core stability exercise alters neuromuscular function to a level that is clinically acceptable and statistically significant. Because of the high incidence rate of secondary ACL injury after ACLR, it is recommended that athletes with a history of ACLR benefit from adding core stability exercises to warm-up routines or tertiary prevention programs even after completing post-operative rehabilitation. It is fast and not time-consuming to perform for athletes to reduce the risk factors of re-injury. Trial registration: This study was registered in the Iranian Registry of Clinical Trials with the number IRCT20190224042827N2, registered on 19 December 2019.

26. Combating lead and cadmium exposure with an orally administered chitosan-based chelating polymer.

Sci Rep

2023 Feb 7

Howard JA, Kuznietsova H, Dziubenko N

27. Solubility of palbociclib in supercritical carbon dioxide from experimental measurement and Peng-Robinson equation of state.

Sci Rep

2023 Feb 7

Sodeifian G, Hsieh CM, Tabibzadeh A

28. Extraction and identification of new flavonoid compounds in dandelion Taraxacum mongolicum Hand.-Mazz. with evaluation of antioxidant activities.

Sci Rep

2023 Feb 7

Wang R, Li W, Fang C

29. Using machine learning to predict venous thromboembolism and major bleeding events following total joint arthroplasty.

Sci Rep

2023 Feb 7

Shohat N, Ludwick L, Sherman MB

Venous thromboembolism (VTE) and major bleeding (MBE) are feared complications that are influenced by numerous host and surgical related factors. Using machine learning on contemporary data, our aim was to develop and validate a practical, easy-to-use algorithm to predict risk for VTE and MBE following total joint arthroplasty (TJA). This was a single institutional study of 35,963 primary and revision total hip (THA) and knee arthroplasty (TKA) patients operated between 2009 and 2020. Fifty-six variables related to demographics, comorbidities, operative factors as well as chemoprophylaxis were included in the analysis. The cohort was divided to training (70%) and test (30%) sets. Four machine learning models were developed for each of the outcomes assessed (VTE and MBE). Models were created for all VTE grouped together as well as for pulmonary emboli (PE) and deep vein thrombosis (DVT) individually to examine the need for distinct algorithms. For each outcome, the model that best performed using repeated cross validation was chosen for algorithm development, and predicted versus observed incidences were evaluated. Of the 35,963 patients included, 308 (0.86%) developed VTE (170 PE's, 176 DVT's) and 293 (0.81%) developed MBE. Separate models were created for PE and DVT as they were found to outperform the prediction of VTE. Gradient boosting trees had the highest performance for both PE (AUC-ROC 0.774 [SD 0.055]) and DVT (AUC-ROC 0.759 [SD 0.039]). For MBE, least absolute shrinkage and selection operator (Lasso) analysis had the highest AUC (AUC-ROC 0.803 [SD 0.035]). An algorithm that provides the probability for PE, DVT and MBE for each specific patient was created. All 3 algorithms had good discriminatory capability and cross-validation showed similar probabilities comparing predicted and observed failures indicating high accuracy of the model. We successfully developed and validated an easy-to-use algorithm that accurately predicts VTE and MBE following TJA. This tool can be used in every-day clinical decision making and patient counseling.

30. Water-in-salt electrolytes made saltier by Gemini ionic liquids for highly efficient Li-ion batteries.

Sci Rep

2023 Feb 7

Tot A, Zhang L, Berg EJ

31. Exploring individual differences in musical rhythm and grammar skills in school-aged children with typically developing language.

Sci Rep

2023 Feb 7

Nitin R, Gustavson DE, Aaron AS

32. Flavescence dorée phytoplasma enters insect cells by a clathrin-mediated endocytosis allowing infection of its insect vector.

Sci Rep

2023 Feb 7

Arricau-Bouvery N, Dubrana MP, Canuto F

33. Salinity and high pH reduce denitrification rates by inhibiting denitrifying gene abundance in a saline-alkali soil.

Sci Rep

2023 Feb 7

Pan Y, She D, Shi Z

Denitrification, as the main nitrogen (N) removal process in farmland drainage ditches in coastal areas, is significantly affected by saline-alkali conditions. To elucidate the effects of saline-alkali conditions on denitrification, incubation experiments with five salt and salt-alkali gradients and three nitrogen addition levels were conducted in a saline-alkali soil followed by determination of denitrification rates and the associated functional genes (i.e., nirK/nirS and nosZ Clade I) via N2/Ar technique in combination with qPCR. The results showed that denitrification rates were significantly decreased by 23.83-50.08%, 20.64-57.31% and 6.12-54.61% with salt gradient increasing from 1 to 3‰, 8‰, and 15‰ under 0.05‰, 0.10‰ and 0.15‰ urea addition conditions, respectively. Similarly, denitrification rates were significantly decreased by 44.57-63.24% with an increase of the salt-alkali gradient from 0.5 to 8‰. The abundance of nosZ decreased sharply in the saline condition, while a high salt level significantly decreased the abundance of nirK and nirS. In addition, the increase of nitrogen concentration attenuated the reduction of nirK, nirS and nosZ gene abundance. Partial least squares regression (PLSR) models demonstrated that salinity, dissolved oxygen (DO) in the overlying water, N concentration, and denitrifying gene abundance were key determinants of the denitrification rate in the saline environment, while pH was an additional determinant in the saline-alkali environment. Taken together, our results suggest that salinity and high pH levels decreased the denitrification rates by significantly inhibiting the abundance of the denitrifying genes nirK, nirS, and nosZ, whereas increasing nitrogen concentration could alleviate this effect. Our study provides helpful information on better understanding of reactive N removal and fertilizer application in the coastal areas.

34. Efficacy of high-volume vs very low volume corticosteroid subacromial injection in subacromial impingement syndrome: a randomized controlled trial.

Sci Rep

2023 Feb 7

Apivatgaroon A, Srimongkolpitak S, Boonsun P

35. Association of hemoglobin variability with the risk of cardiovascular disease: a nationally representative retrospective cohort study from South Korea.

Sci Rep

2023 Feb 7

Lee WJ, Choi S, Park SM

36. A conserved SNP variation in the pre-miR396c flanking region in Oryza sativa indica landraces correlates with mature miRNA abundance.

Sci Rep

2023 Feb 7

Jaganathan D(#), Rajakani R(#), Doddamani D

37. Translating principles of quality control to cardiovascular magnetic resonance: assessing quantitative parameters of the left ventricle in a large cohort.

Sci Rep

2023 Feb 7

Riazy L(#), Däuber S(#), Lange S

38. The effect of Computer Assisted Rehabilitation Environment (CAREN) in cognitive impairment and coping strategies in Parkinson's disease: a preliminary study.

Sci Rep

2023 Feb 7

Formica C, Bonanno L, Latella D

39. Integrative taxonomy reveals new, widely distributed tardigrade species of the genus Paramacrobiotus (Eutardigrada: Macrobiotidae).

Sci Rep

2023 Feb 7

Kayastha P, Stec D, Sługocki Ł

40. Optimal spatial evaluation of a pro rata vaccine distribution rule for COVID-19.

Sci Rep

2023 Feb 7

Castonguay FM, Blackwood JC, Howerton E

41. Population genetic analysis of Plasmodium knowlesi reveals differential selection and exchange events between Borneo and Peninsular sub-populations.

Sci Rep

2023 Feb 7

Turkiewicz A, Manko E, Oresegun DR

The zoonotic Plasmodium knowlesi parasite is a growing public health concern in Southeast Asia, especially in Malaysia, where elimination of P. falciparum and P. vivax malaria has been the focus of control efforts. Understanding of the genetic diversity of P. knowlesi parasites can provide insights into its evolution, population structure, diagnostics, transmission dynamics, and the emergence of drug resistance. Previous work has revealed that P. knowlesi fall into three main sub-populations distinguished by a combination of geographical location and macaque host (Macaca fascicularis and M. nemestrina). It has been shown that Malaysian Borneo groups display profound heterogeneity with long regions of high or low divergence resulting in mosaic patterns between sub-populations, with some evidence of chromosomal-segment exchanges. However, the genetic structure of non-Borneo sub-populations is less clear. By gathering one of the largest collections of P. knowlesi whole-genome sequencing data, we studied structural genomic changes across sub-populations, with the analysis revealing differences in Borneo clusters linked to mosquito-related stages of the parasite cycle, in contrast to differences in host-related stages for the Peninsular group. Our work identifies new genetic exchange events, including introgressions between Malaysian Peninsular and M. nemestrina-associated clusters on various chromosomes, including in parasite invasion genes (DBP[Formula: see text], NBPX[Formula: see text] and NBPX[Formula: see text]), and important proteins expressed in the vertebrate parasite stages. Recombination events appear to have occurred between the Peninsular and M. fascicularis-associated groups, including in the DBP[Formula: see text] and DBP[Formula: see text] invasion associated genes. Overall, our work finds that genetic exchange events have occurred among the recognised contemporary groups of P. knowlesi parasites during their evolutionary history, leading to apparent mosaicism between these sub-populations. These findings generate new hypotheses relevant to parasite evolutionary biology and P. knowlesi epidemiology, which can inform malaria control approaches to containing the impact of zoonotic malaria on human communities.

42. Deposition of carbon from methane on manganese sources.

Sci Rep

2023 Feb 7

Dalaker H, Gjøvik JE, Ringdalen E.

43. A deep learning model for detection of leukocytes under various interference factors.

Sci Rep

2023 Feb 7

Li M(#), Lin C(#), Ge P

44. The relationship of social determinants and distress in newly diagnosed cancer patients.

Sci Rep

2023 Feb 7

Okeke B, Hillmon C, Jones J

45. Nonlinear Rayleigh wave propagation in a layered half-space in dual-phase-lag.

Sci Rep

2023 Feb 7

Youssef AA, Amein NK, Abdelrahman NS

46. Investigation of structural, optical, morphological, photoluminescence and antimicrobial properties of SrAl(2)O(4):Eu(2+) nanophosphor by using urea fuel combustion method.

Sci Rep

2023 Feb 7

Litoriya PK, Kurmi S, Verma A.

47. Nanocellulose reinforced lightweight composites produced from cotton waste via integrated nanofibrillation and compounding.

Sci Rep

2023 Feb 7

Liang D, Liu W, Zhong T

48. The effects of sun exposure on colorant identification of permanently and semi-permanently dyed hair.

Sci Rep

2023 Feb 7

Holman A, Kurouski D.

49. Handwriting kinematics during learning to write with the dominant left hand in converted left-handers.

Sci Rep

2023 Feb 7

Stetter L, Sattler JB, Marquardt C

Converting left-handers to their non-dominant right hand was previously widespread, particularly for handwriting. The present study aimed to explore the extent to which adult, converted left-handers can learn writing with their dominant left hand during a 2-year training program. Eleven converted left-handers participated in the training. Handwriting kinematics were assessed at regular intervals (seven sessions) and compared to those of 11 innate left-handed controls matched for age, gender, and overall handedness score for basic (Finger, Wrist, Circle) and complex (Sentence, Copy) handwriting tasks. Regarding basic tasks in the training group, we found rapid increases in left and right-hand frequency and no significant differences between both hands at any time point, indicating successful hand transfer. After 24 months, training participants significantly surpassed controls for writing frequency in basic tasks with their left hand. For complex tasks, we identified significant increases in the training groups' left-hand writing frequency and duration between the first and last session. While training participants' left-hand writing remained significantly slower than their right-hand writing, statistics confirmed final differences between hands only for the duration of the Sentence task. Importantly, left-hand writing in the training group was characterized by lower frequency, lower automaticity, and prolonged duration after 24 months compared to innate left-handers. With training participants' left-hand writing skills significantly increasing for complex tasks and no final statistically significant differences between hands for frequency and automaticity, the program was considered effective. Nevertheless, within 2 years, training participants did not reach innate left-handers handwriting proficiency for complex tasks. Underlying reasons may be various, such as a non-optimal training program, a sensitive period for learning to write, irreversible neural changes during conversion in childhood, age-related decline of motor learning capacity, or retrograde interference between right- and left-hand writing.

50. Individual attractiveness preferences differentially modulate immediate and voluntary attention.

Sci Rep

2023 Feb 7

Roth TS(#), Samara I(#), Perea-Garcia JO

51. Prediction of hydrophilic and hydrophobic hydration structure of protein by neural network optimized using experimental data.

Sci Rep

2023 Feb 7

Sato K, Oide M, Nakasako M.

52. Using optimal controlled singlet spin order to accurately target molecular signal in MRI and MRS.

Sci Rep

2023 Feb 7

Xin JX, Yang G, Zhang H

53. Synchrotron-based operando X-ray diffraction and X-ray absorption spectroscopy study of LiCo(0.5)Fe(0.5)PO(4) mixed d-metal olivine cathode.

Sci Rep

2023 Feb 7

Hamdalla TA, Aboraia AM, Shapovalov VV

54. Prediction of the shear capacity of ultrahigh-performance concrete beams using neural network and genetic algorithm.

Sci Rep

2023 Feb 7

Hou R, Hou Q.

55. Part orientation optimization for Wire and Arc Additive Manufacturing process for convex and non-convex shapes.

Sci Rep

2023 Feb 7

Alomari Y, Birosz MT, Andó M.

56. Outcomes of a computer-based cognitive training (CoRe) in early phases of cognitive decline: a data-driven cluster analysis.

Sci Rep

2023 Feb 7

Bernini S, Gerbasi A, Panzarasa S

57. Multidisciplinary approach to the study of large-format oil paintings.

Sci Rep

2023 Feb 7

Calderón-Mesén P(#), Jaikel-Víquez D(#), Barrantes-Madrigal MD(#)

Cultural heritage has become a keystone for comprehending our society, as it represents and reflects our origins, passions, beliefs and traditions. Furthermore, it provides fundamental information about specific temporary spaces, materials' availability, technology, artist's intention, and site weather conditions. Our aim was to develop a multidisciplinary approach with a main focus on investigating two Italian large-format paintings located in highly diverse environments such as the National Theater of Costa Rica. We monitored environmental conditions and quantified fungal aerial spores. Then, we determined regions of possible biodeterioration with the software MicroorganismPattern and used the software PigmentArrangement to elucidate the apparent colour of the paintings based on distribution and arrangement of the pigment crystals. Finally, we characterized eight genera of calcareous nannofossils found in the ground layers of the artwork. The former Men's Canteen at the National Theater of Costa Rica presented a mean air temperature of 23.5 [Formula: see text]C, a relative humidity of 72.7% and a concentration of CO[Formula: see text] of 570 ppm. The fungal aerial concentration was 1776 spores/m[Formula: see text]. The software MicroorganismPattern identified 32 sampling regions, out of which 11 were positive for microbial contamination. The software PigmentArrangement determined that the blue crystals (ultramarine pigment) had the shortest distances between themselves (29 [Formula: see text]m). Finally, the nanofossils identified enabled us to restrict the age of the material to a biostratigraphic interval ranging from Coniacian to Maastricthian ages. By using a multidisciplinary approach we were able to explore the diptych, suggest a set of minimally invasive perspectives in tropical environments to be used worldwide and obtain key information about the artist's artistic process, materials used along with better understand its state of conservation.

58. Group threat, political extremity, and collective dynamics in online discussions.

Sci Rep

2023 Feb 7

Bacaksizlar Turbic NG, Galesic M.

59. Shape classification technology of pollinated tomato flowers for robotic implementation.

Sci Rep

2023 Feb 7

Hiraguri T, Kimura T, Endo K

60. Up-conversion emission in transition metal and lanthanide co-doped systems: dimer sensitization revisited.

Sci Rep

2023 Feb 7

Avram D, Colbea C, Patrascu AA

61. The unique fibrilar to platy nano- and microstructure of twinned rotaliid foraminiferal shell calcite.

Sci Rep

2023 Feb 7

Lastam J, Griesshaber E, Yin X

62. Reconciling policy instruments with drivers of deforestation and forest degradation: cross-scale analysis of stakeholder perceptions in tropical countries.

Sci Rep

2023 Feb 7

Ferrer Velasco R, Lippe M, Fischer R

63. Efficient methodology with potential uses of Fresnel diffractometry for real-time study of uniaxial nematic liquid crystal phase transitions.

Sci Rep

2023 Feb 7

Madadi N, Amiri M.

64. Dynamical response and noise limit of a parametrically pumped microcantilever sensor in a Phase-Locked Loop.

Sci Rep

2023 Feb 7

Mouro J, Paoletti P, Sartore M

65. Restoration of insect communities after land use change is shaped by plant diversity: a case study on carabid beetles (Carabidae).

Sci Rep

2023 Feb 7

Lange M, Ebeling A, Voigt W

66. Retrospective analysis of drug resistance characteristics and infection related risk factors of multidrug-resistant organisms (MDROs) isolated from the orthopedics department of a tertiary hospital.

Sci Rep

2023 Feb 7

Yang X(#), Guo R(#), Zhang B(#)

Patients infected with multidrug-resistant organisms (MDROs) are known to exhibit longer hospital stays and a significantly poorer prognosis. We performed a 6-year retrospective analysis of nosocomial infections reported in the orthopedics department of our institution, to gain valuable insights into antibiotic sensitivity and infectious characteristics of MDROs, in order to deduce effective measures to control the occurrence of multidrug-resistant infections in clinical practice. A retrospective, single center surveillance study (January 2012-December 2017) was performed on the nosocomial infections recorded in the department of orthopedics. A nosocomial infection is defined as one that develops when a patient is residing in a hospital but was not present at the time of admission. All relevant data, including basic patient information, cultivated bacterial strains, and antimicrobial resistance, was obtained from the hospital information system. A total of 1392 strains of pathogenic bacteria were isolated; 358 belonged to MDROs (detection rate = 25.7%). All the isolated strains of MDROs were mostly from secretions (52.2%). The number of cases infected with MDROs were 144 (40.2%) and 129 (36.0%) in the trauma and spinal wards, respectively. MRSA showed high resistance to β lactam antibiotics, but was sensitive to quinolone antibiotics, linezolid and cotrimoxazole. ESBL-positive strains showed more sensitivity to carbapenem antibiotics (resistance rate < 10%). MDR nonfermenters showed high resistance to most antibiotics. Logistic multivariate analysis revealed age, open injury, and central nervous system injury as independent risk factors for multidrug resistant infections. A high antibiotic resistance rate and an increasing prevalence of infections with MDROs was identified in the orthopedics department. Patients with open injury, central nervous system injury and those aged ≥ 60 years, were more prone to multidrug-resistant infections. Clinicians should pay more attention to such patients in order to actively prevent and control the occurrence of infections caused by MDROs.

67. Dynamic response characteristics and damage rule of graphite ore rock under different strain rates.

Sci Rep

2023 Feb 7

Ye H, Li X, Lei T

In the process of mining graphite mine, rock mass is often subjected to dynamic loads such as blasting or mechanical crushing, which involves dynamic responses of different strain rates, and blasting and crushing effect are affected by the rock dynamic properties and damage specials. The dynamic response characteristics and damage rule of graphite ore rock under different strain rates are very important but rarely studied in the past. To study these issues and provide support for graphite ore rock mining, the dynamic compression tests of graphite ore rock under five kinds of impact pressures were designed and carried out by using the Split Hopkinson Pressure Bar (SHPB) test system, combining with the high-speed photography system and crushing screening tests. The dynamic characteristics, crushing process, crushing mode, crushing form and fragmentation distribution of the graphite ore rock under different strain rates were analyzed. The results show that the dynamic characteristics of the graphite ore rock have obvious strain rate effect. The hardening coefficient (DIF) is positively correlated with the cubic root of strain rate, and the softening factor (K) is negatively correlated with the cubic root of strain rate. Shear failure mainly occurs in the graphite ore rock under impact load, and the crushing process can be divided into five stages, they are compaction, crack initiation, crack expansion and penetration, fragmentation collision and fragmentation fall. In addition, the crushed blocks are mainly triangular pyramid (or cone-like) fine granular and powder. The broken fragments of the graphite ore rock are in accord with the fractal geometry characteristics. That is, the average broken particle size (dS) decreases linearly with the increase of strain rate, and the fractal dimension (Da) increases weakly with the increase of strain rate. Based on D-P fracture criterion and Weibull distribution model, the dynamic damage constitutive model of the graphite ore rock was established, and the correlation between strain rate and Weibull distribution parameters (m and F0) was used to reasonably modify the damage constitutive model. The modified damage constitutive model curve is in good agreement with the experimental curve, which can basically reflect the strain rate effect of the dynamic characteristics of the graphite ore rock and the evolution characteristics of the dynamic stress-strain curve at different stage.

68. Hydrogen production by the steam reforming of synthetic biogas in atmospheric-pressure microwave (915 MHz) plasma.

Sci Rep

2023 Feb 7

Hrycak B, Mizeraczyk J, Czylkowski D

69. The importance of the Andes in the evolutionary radiation of Sigmodontinae (Rodentia, Cricetidae), the most diverse group of mammals in the Neotropics.

Sci Rep

2023 Feb 7

Vallejos-Garrido P, Pino K, Espinoza-Aravena N

70. A novel ZnS-CdS nanocomposite as a visible active photocatalyst for degradation of synthetic and real wastewaters.

Sci Rep

2023 Feb 7

Khodamorady M, Bahrami K.

71. White Laue and powder diffraction studies to reveal mechanisms of HCP-to-BCC phase transformation in single crystals of Mg under high pressure.

Sci Rep

2023 Feb 7

Vasilev E, Popov D, Somayazulu M

72. Transportation of nanomaterial Maxwell fluid flow with thermal slip under the effect of Soret-Dufour and second-order slips: nonlinear stretching.

Sci Rep

2023 Feb 7

Abbas N, Shatanawi W, Shatnawi TAM.

73. Scenarios of land use and land cover change in the Colombian Amazon to evaluate alternative post-conflict pathways.

Sci Rep

2023 Feb 7

Agudelo-Hz WJ, Castillo-Barrera NC, Uriel MG.

74. New constraints of terrestrial and oceanic global gross primary productions from the triple oxygen isotopic composition of atmospheric CO(2) and O(2).

Sci Rep

2023 Feb 7

Liang MC, Laskar AH, Barkan E

75. Evaluation and remediation protocol of selected organochlorine pesticides and heavy metals in industrial wastewater using nanoparticles (NPs) in Nigeria.

Sci Rep

2023 Feb 7

Nnaji JC, Amaku JF, Amadi OK

76. CASPR2 antibody associated neurological syndromes in children.

Sci Rep

2023 Feb 6

Wu L, Cai F, Zhuo Z

77. Plant miRNA osa-miR172d-5p suppressed lung fibrosis by targeting Tab1.

Sci Rep

2023 Feb 6

Kumazoe M(#), Ogawa F(#), Hikida A

78. Risk of mortality in COVID-19 patients: a meta- and network analysis.

Sci Rep

2023 Feb 6

Kowsar R, Rahimi AM, Sroka M

79. Quantifying human performance in chess.

Sci Rep

2023 Feb 6

Chowdhary S, Iacopini I, Battiston F.

80. Monocyte subsets and monocyte-related chemokines in Takayasu arteritis.

Sci Rep

2023 Feb 6

de Aguiar MF, Torquato H, Salu BR

81. Quantum error mitigation by Pauli check sandwiching.

Sci Rep

2023 Feb 6

Gonzales A, Shaydulin R, Saleem ZH

82. Node-based generalized friendship paradox fails.

Sci Rep

2023 Feb 6

Evtushenko A, Kleinberg J.

83. Synthesis, characterization, and evaluation of Hesperetin nanocrystals for regenerative dentistry.

Sci Rep

2023 Feb 6

Alipour M, Sharifi S, Samiei M

84. Ketogenic diet for epilepsy control and enhancement in adaptive behavior.

Sci Rep

2023 Feb 6

El-Rashidy OF, Nassar MF, Shokair WA

85. Denervation during mandibular distraction osteogenesis results in impaired bone formation.

Sci Rep

2023 Feb 6

Tevlin R, Griffin M, Chen K

86. Application of neural network-based image analysis to detect sister chromatid cohesion defects.

Sci Rep

2023 Feb 6

Ikemoto D, Taniguchi T, Hirota K

87. Reference-free lossless compression of nanopore sequencing reads using an approximate assembly approach.

Sci Rep

2023 Feb 6

Meng Q(#), Chandak S(#), Zhu Y(#)

88. High-precision automatic identification method for dicentric chromosome images using two-stage convolutional neural network.

Sci Rep

2023 Feb 6

Shen X, Ma T, Li C

89. In silico and in vitro anti-inflammatory study of phenolic compounds isolated from Eucalyptus maculata resin.

Sci Rep

2023 Feb 6

Ali DE(#), Gedaily RAE(#), Ezzat SM

90. Simple curettage and allogeneic cancellous bone chip impaction grafting in solitary enchondroma of the short tubular bones of the hand.

Sci Rep

2023 Feb 6

Park HY, Joo MW, Choi YH

91. Hydrogen migration in inner-shell ionized halogenated cyclic hydrocarbons.

Sci Rep

2023 Feb 6

Abid AR, Bhattacharyya S, Venkatachalam AS

92. Study on the application of optical coherence microscopy in Hirschsprung's disease.

Sci Rep

2023 Feb 6

Wu Z(#), Song J(#), Zeng X

93. Discovering novel clues of natural selection on four worldwide goat breeds.

Sci Rep

2023 Feb 6

Manunza A(#), Diaz JR(#), Sayre BL

94. Reduced cardiovascular reserve capacity in long-term allogeneic stem cell transplant survivors.

Sci Rep

2023 Feb 6

Dillon HT, Foulkes S, Horne-Okano YA

Premature cardiovascular mortality is increased in long-term allogeneic stem cell transplant (allo-SCT) survivors, but little information exists regarding subclinical cardiovascular dysfunction in this population. We compared peak oxygen uptake ([Formula: see text]O2peak), a prognostic cardiovascular marker, and its determinants between long-term allo-SCT survivors and non-cancer controls. Fourteen allo-SCT survivors (mean ± SD, 44 ± 15 years, 50% male, median time since allo-SCT: 6.5 years [range 2-20]) and 14 age- and sex-matched controls (46 ± 13 years, 50% male) underwent cardiopulmonary exercise testing to quantify [Formula: see text]O2peak. Resting echocardiography (left-ventricular ejection fraction and strain), exercise cardiac MRI (peak cardiac and stroke volume index [CIpeak, SVIpeak]), biochemistry (hemoglobin, troponin-I, B-natriuretic peptide), dual-energy x-ray absorptiometry (lean [LM] and fat [FM] mass, percent body fat [%BF]) and Fick-principal calculation (arteriovenous oxygen difference) were also performed. Survivors exhibited impaired [Formula: see text]O2peak as compared with controls (25.9 ± 5.1 vs. 33.7 ± 6.5 ml kg-1 min-1, p = 0.002), which coincided with reduced CIpeak (6.6 ± 0.8 vs. 8.6 ± 1.9 L min-1 m-2; p = 0.001) secondary to reduced SVIpeak (48 ± 4 vs. 61 ± 8 ml m-2; p < 0.001) rather than chronotropic impairment, and higher %BF (difference, 7.9%, p = 0.007) due to greater FM (5.8 kg; p = 0.069) and lower LM (4.3 kg, p = 0.25). All other measures were similar between groups. Despite comparable resting cardiac function and biomarker profiles, survivors exhibited reduced [Formula: see text]O2peak and exercise cardiac function and increased %BF relative to controls. These results highlight potential therapeutic avenues and the utility of exercise-based cardiovascular assessment in unmasking cardiovascular dysfunction in allo-SCT survivors.

95. Exogenous melatonin alleviates neuropathic pain-induced affective disorders by suppressing NF-κB/ NLRP3 pathway and apoptosis.

Sci Rep

2023 Feb 6

Mokhtari T, Yue LP, Hu L.

96. Engineered mineralogical interfaces as radionuclide repositories.

Sci Rep

2023 Feb 6

Douglas GB, Reddy SM, Saxey DW

97. Consolidation of metabolomic, proteomic, and GWAS data in connective model of schizophrenia.

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2023 Feb 6

Kopylov AT(#), Stepanov AA(#), Butkova TV

98. Recombinant anti-HIV MAP30, a ribosome inactivating protein: against plant virus and bacteriophage.

Sci Rep

2023 Feb 6

Amirzadeh N, Moghadam A, Niazi A

99. Microwave-sensor-node integrated into a short-range wireless sensor network.

Sci Rep

2023 Feb 6

Hernandez-Aguila M, Olvera-Cervantes JL, Perez-Ramos AE

100. Spatiotemporal dynamics and environmental determinants of scrub typhus in Anhui Province, China, 2010-2020.

Sci Rep

2023 Feb 6

Wei X(#), He J(#), Yin W(#)

101. Simultaneous detection of omicron and other SARS-CoV-2 variants by multiplex PCR MassARRAY technology.

Sci Rep

2023 Feb 6

Wacharapluesadee S, Hirunpatrawong P, Petcharat S

102. Screening of novel peptides that specifically interact with vitamin D bound biocomplex proteins.

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2023 Feb 6

Kim T, Lee J, Lee JP

103. Ferroptosis-associated lncRNA prognostic signature predicts prognosis and immune response in clear cell renal cell carcinoma.

Sci Rep

2023 Feb 6

Lai J, Miao S, Ran L.

104. Time-scale synchronisation of oscillatory responses can lead to non-monotonous R-tipping.

Sci Rep

2023 Feb 6

Swierczek-Jereczek J, Robinson A, Blasco J

105. AI-accelerated protein-ligand docking for SARS-CoV-2 is 100-fold faster with no significant change in detection.

Sci Rep

2023 Feb 6

Clyde A(#), Liu X(#), Brettin T

106. An in-depth analysis of four classes of antidepressants quantification from human serum using LC-MS/MS.

Sci Rep

2023 Feb 6

Fariha R, Deshpande PS, Rothkopf E

107. Hg(II) immobilization and detection using gel formation with tetra-(4-pyridylphenyl)ethylene and an aggregation-induced luminescence effect.

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2023 Feb 6

Hu B, Wei T, Cui Y

108. Comparative proteome analysis of different Saccharomyces cerevisiae strains during growth on sucrose and glucose.

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2023 Feb 6

Soares Rodrigues CI, den Ridder M, Pabst M

109. Potential roles of acyl homoserine lactones (AHLs) in nitrifying bacteria survival under certain adverse circumstances.

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2023 Feb 6

Zeng X, Hu H.

110. Association of polysialic acid serum levels with schizophrenia spectrum and bipolar disorder-related structural brain changes and hospitalization.

Sci Rep

2023 Feb 6

Müller-Miny L(#), Thiel K(#), Meinert S

111. ADAR1 is a promising risk stratification biomarker of remnant liver recurrence after hepatic metastasectomy for colorectal cancer.

Sci Rep

2023 Feb 6

Hata N, Shigeyasu K, Umeda Y

112. H-CoNiSe(2)/NC dodecahedral hollow structures for high-performance supercapacitors.

Sci Rep

2023 Feb 6

Salehan P, Ensafi AA, Andikaey Z

113. Evidence of structural segmentation of the Uttarakhand Himalaya and its implications for earthquake hazard.

Sci Rep

2023 Feb 6

Mandal P, Prathigadapa R, Srinivas D

114. Ovicidal toxicity of plant essential oils and their major constituents against two mosquito vectors and their non-target aquatic predators.

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2023 Feb 6

Moungthipmalai T, Puwanard C, Aungtikun J

115. Allolobophora caliginosa coelomic fluid and extract alleviate glucocorticoid-induced osteoporosis in mice by suppressing oxidative stress and regulating osteoblastic/osteoclastic-related markers.

Sci Rep

2023 Feb 6

Abdelfattah MA, Mohamed AS, Ibrahim SA

116. In silico analysis of TUBA4A mutations in Amyotrophic Lateral Sclerosis to define mechanisms of microtubule disintegration.

Sci Rep

2023 Feb 6

Ganne A(#), Balasubramaniam M(#), Ayyadevara H

Amyotrophic lateral sclerosis (ALS) is an inexorably progressive and degenerative disorder of motor neurons with no currently-known cure. Studies to determine the mechanism of neurotoxicity and the impact of ALS-linked mutations (SOD1, FUS, TARDP, C9ORF72, PFN1, TUBA4A and others) have greatly expanded our knowledge of ALS disease mechanisms and have helped to identify potential targets for ALS therapy. Cellular pathologies (e.g., aggregation of mutant forms of SOD1, TDP43, FUS, Ubiqulin2, PFN1, and C9ORF72), mitochondrial dysfunction, neuroinflammation, and oxidative damage are major pathways implicated in ALS. Nevertheless, the selective vulnerability of motor neurons remains unexplained. The importance of tubulins for long-axon infrastructure, and the special morphology and function of motor neurons, underscore the central role of the cytoskeleton. The recent linkage of mutations to the tubulin α chain, TUBA4A, to familial and sporadic cases of ALS provides a new investigative opportunity to shed light on both mechanisms of ALS and the vulnerability of motor neurons. In the current study we investigate TUBA4A, a structural microtubule protein with mutations causal to familial ALS, using molecular-dynamic (MD) modeling of protein structure to predict the effects of each mutation and its overall impact on GTP binding, chain stability, tubulin assembly, and aggregation propensity. These studies predict that each of the reported mutations will cause notable structural changes to the TUBA4A (α chain) tertiary protein structure, adversely affecting its physical properties and functions. Molecular docking and MD simulations indicate certain α chain mutations (e.g. K430N, R215C, and W407X) may cause structural deviations that impair GTP binding, and plausibly prevent or destabilize tubulin polymerization. Furthermore, several mutations (including R320C and K430N) confer a significant increase in predicted aggregation propensity of TUBA4A mutants relative to wild-type. Taken together, these in silico modeling studies predict structural perturbations and disruption of GTP binding, culminating in failure to form a stable tubulin heterocomplex, which may furnish an important pathogenic mechanism to trigger motor neuron degeneration in ALS.

117. Tumor-infiltrating T cells as a risk factor for lymph node metastasis in patients with submucosal colorectal cancer.

Sci Rep

2023 Feb 6

Kitakaze M, Fujino S, Miyoshi N

118. Association between pazopanib exposure and safety in Japanese patients with renal cell carcinoma or soft tissue sarcoma.

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2023 Feb 6

Aoyama T, Nakano K, Yuasa T

119. Bacteriological spectrum, extended-spectrum β-lactamase production and antimicrobial resistance pattern among patients with bloodstream infection in Addis Ababa.

Sci Rep

2023 Feb 6

Bitew A, Adane A, Abdeta A.

120. Increased expression of the immunoproteasome subunits PSMB8 and PSMB9 by cancer cells correlate with better outcomes for triple-negative breast cancers.

Sci Rep

2023 Feb 6

Geoffroy K, Araripe Saraiva B(#), Viens M(#)

121. Three-dimensional visualization of the total mesorectal excision plane for dissection in rectal cancer surgery and its ability to predict surgical difficulty.

Sci Rep

2023 Feb 6

Nagai Y, Kawai K, Nozawa H

122. Machine learning classifiers predict key genomic and evolutionary traits across the kingdoms of life.

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2023 Feb 6

Hallee L, Khomtchouk BB.

123. Introduction of a cascaded segmentation pipeline for parametric T1 mapping in cardiovascular magnetic resonance to improve segmentation performance.

Sci Rep

2023 Feb 6

Viezzer D, Hadler T, Ammann C

124. Serum levels of anti-Müllerian hormone influence pregnancy outcomes associated with gonadotropin-releasing hormone antagonist treatment: a retrospective cohort study.

Sci Rep

2023 Feb 6

Hou Y(#), Wang L(#), Li Y

125. Feature-enhanced text-inception model for Chinese long text classification.

Sci Rep

2023 Feb 6

Yang G, Jiayu Y, Dongdong X

126. A nomogram for predicting postoperative urosepsis following retrograde intrarenal surgery in upper urinary calculi patients with negative preoperative urine culture.

Sci Rep

2023 Feb 6

Yang M, Li Y, Huang F.

127. Dual RNA sequencing of group B Streptococcus-infected human monocytes reveals new insights into host-pathogen interactions and bacterial evasion of phagocytosis.

Sci Rep

2023 Feb 6

Sullivan MJ, Prince D, Goh KGK

128. A methodological tool for sustainability and feasibility assessment of indoor vertical farming with artificial lighting in Africa.

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2023 Feb 6

Paucek I, Durante E, Pennisi G

129. Composition and taste of beef, pork, and duck meat and bioregulatory functions of imidazole dipeptides in meat.

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2023 Feb 6

Kajiya K, Arino M, Koshio A

130. Joint use of location and acceleration data reveals influences on transitions among habitats in wintering birds.

Sci Rep

2023 Feb 6

VonBank JA, Schafer TLJ, Cunningham SA

131. The volatile organic compounds and palatability of mixed ensilage of marigold (Tagetes erecta L.) crop residues.

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2023 Feb 6

Hou Z(#), Liu J(#), Cai M

132. A granular mechanics model study of the influence of non-spherical shape on aggregate collisions.

Sci Rep

2023 Feb 6

Bandyopadhyay R, Urbassek HM.

133. Evaluation of solar photovoltaic carport canopy with electric vehicle charging potential.

Sci Rep

2023 Feb 6

Fakour H, Imani M, Lo SL

134. Mind evolutionary algorithm optimization in the prediction of satellite clock bias using the back propagation neural network.

Sci Rep

2023 Feb 6

Bai H, Cao Q, An S.

135. MiRNA-30d and miR-770-5p as potential clinical risk predictors of Vasoplegic Syndrome in Patients undergoing on-pump coronary artery bypass grafting.

Sci Rep

2023 Feb 6

Vilca Mejia OA(#), de Souza RC(#), S Santos A

136. Hedonism as a motive for information search: biased information-seeking leads to biased beliefs.

Sci Rep

2023 Feb 6

Jiwa M, Cooper PS, Chong TT

137. Three-dimensional evaluation of the maxillary sinus in patients with different skeletal classes and cranio-maxillary relationships assessed with cone beam computed tomography.

Sci Rep

2023 Feb 6

Abate A(#), Cavagnetto D(#), Lanteri V(#)

The objective was to evaluate the relationship between the dimensions of the maxillary sinuses (MSs) and various cephalometric parameters. MS volume (MSV), MS surface (MSS), linear maximum depth (LMD), linear maximum width (LMW), and linear maximum height (LMH) were calculated on CBCT scans of 99 adults. Two sets of two-way (ANOVA) assessed the influence respectively of ANB and SNA angles and of the gender on MS dimensions. Pearson's correlation was calculated between MS dimensions and different cephalometric variables. Reliability and accuracy of the proposed method was tested with intra-operator and inter-operator intraclass correlation coefficient (ICC). Two-way ANOVA showed no statistically significant difference in MSV, MSS and LMH between ANB groups, whilst males were associated with bigger sinuses. LMW showed statistically significant difference in both ANB and gender groups. LMD showed no statistically significant difference. The second Two-way ANOVA showed significantly larger MSV, MSS and LMD in patients with increased or reduced SNA angle but not between genders. LMW and LMH also showed a significant difference between genders. All linear measurements showed a significant interaction of the two factors. The intra-observer and inter-observer ICC scored high for all the tested measurements. MSV and MSS showed a positive correlation with S-N, PNS-A, S-Go, N-Me, N-Ans and the distance between Mx points. LMW had a negative correlation with Ba-S-N angle and N-Me, LMH with Ba-S-N angle, S-Go and Mx r-Mx l and LMD with N-Me and N-ANS. LMW had a positive correlation with Mx r-Mx l, LMH with S-N, S-N^Ans-Pns, N-Me, N-Ans and LMD with S-N, Ba-S-N, PNS-A, S-Go and distance between Mx points. In conclusion, MSV and MSS did not differ between the three skeletal classes, males showed significantly larger MS than in females. Concerning the influence of the cranio-maxillary relationship (SNA) and gender on MS dimension, subjects with a retrusion (SNA < 80°) or protusion (SNA > 84°) of the maxillary alveolar bone had larger MSV, MSS, LMW, LMH and LMD than subjects with a normal cranio-maxillary relationship (SNA 82 ± 2°). A statistically significant high positive correlation was observed between S-N, Pns-A, S-Go, Mx-R/Mx-r and MS dimension. Further studies that evaluate similar outcomes in different races may be able to enrich our knowledge on this topic.

138. A numerical study towards shape memory alloys application in orthotic management of pediatric knee lateral deviations.

Sci Rep

2023 Feb 6

Alonso MG, Yawny A(#), Bertolino G(#).

139. Exact solutions of [Formula: see text]-dependent Schrödinger equation with quantum pseudo-harmonic oscillator and its applications for the thermodynamic properties in normal and superstatistics.

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2023 Feb 6

Okorie US, Ikot AN, Okon IB

140. Role of vanadium ions substitution on spinel MnCo(2)O(4) towards enhanced electrocatalytic activity for hydrogen generation.

Sci Rep

2023 Feb 6

Mohamed MJS, Slimani Y, Gondal MA

141. Nearly-freestanding supramolecular assembly with tunable structural properties.

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2023 Feb 5

Caruso T(#), De Luca O(#), Melfi N

142. Association between cannabis use and blood pressure levels according to comorbidities and socioeconomic status.

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2023 Feb 5

Vallée A.

143. Purinergic signaling during Marek's disease in chickens.

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2023 Feb 4

Akbar H, Fasick JJ, Ponnuraj N

144. Absolute dosimetry for FLASH proton pencil beam scanning radiotherapy.

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2023 Feb 4

Lourenço A, Subiel A, Lee N

145. Understanding microbiome dynamics via interpretable graph representation learning.

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2023 Feb 4

Melnyk K, Weimann K, Conrad TOF.

146. The restoration and erection of the world's first elevated obelisk.

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2023 Feb 4

Saleh AM, Mourad SA, Elanwar HH

147. Molecular phylogeny reveals distinct evolutionary lineages of the banded krait, Bungarus fasciatus (Squamata, Elapidae) in Asia.

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2023 Feb 4

Biakzuala L, Lalremsanga HT, Santra V

148. The distribution of blinkrate among Malawian young adults: a cross-sectional study.

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2023 Feb 4

Mbamba M, Mzumara T, Chisale P

149. The synergetic effect of sitafloxacin-arbekacin combination in the Mycobacterium abscessus species.

Sci Rep

2023 Feb 4

Watanabe J, Ihara H, Takei S

150. Establishing a simple perfusion cell culture system for light-activated liposomes.

Sci Rep

2023 Feb 4

Mäki-Mikola E, Lauren P, Uema N

151. Coordinated local RNA overexpression of complement induced by interferon gamma in myositis.

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2023 Feb 4

Casal-Dominguez M(#), Pinal-Fernandez I(#), Pak K

152. SH2D4A promotes centrosome maturation to support spindle microtubule formation and mitotic progression.

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2023 Feb 4

Yuki R, Ikeda Y, Yasutake R

153. PRR11 is a prognostic biomarker and correlates with immune infiltrates in bladder urothelial carcinoma.

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2023 Feb 4

Ni W(#), Yi L(#), Dong X

154. Noncanonical regulation of imprinted gene Igf2 by amyloid-beta 1-42 in Alzheimer's disease.

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2023 Feb 4

Fertan E, Gendron WH, Wong AA

155. Metabolomic profiling in kidney cells treated with a sodium glucose-cotransporter 2 inhibitor.

Sci Rep

2023 Feb 4

Jo HA(#), Seo JH(#), Lee S

156. Rigidity control mechanism by turgor pressure in plants.

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2023 Feb 4

Kanahama T, Tsugawa S, Sato M.

157. Macromolecular crowding regulates matrix composition and gene expression in human gingival fibroblast cultures.

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2023 Feb 4

Ramalingam R, Jiang G, Larjava H

158. Clinical characteristics depending on magnetic resonance imaging patterns in idiopathic isolated optic neuritis.

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2023 Feb 4

Park SM, Kim US.

159. Nicotine exposure decreases likelihood of SARS-CoV-2 RNA expression and neuropathology in the hACE2 mouse brain but not moribundity.

Sci Rep

2023 Feb 4

Letsinger AC, Ward JM, Fannin RD

160. The onset of rare earth metallosis begins with renal gadolinium-rich nanoparticles from magnetic resonance imaging contrast agent exposure.

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2023 Feb 4

DeAguero J, Howard T, Kusewitt D

161. Impact of lamina-open side on unilateral open door laminoplasty in patients with degenerative cervical myelopathy.

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2023 Feb 4

Kang KC, Im SK, Lee JH

162. Blocking of PI3-kinase beta protects against cerebral ischemia/reperfusion injury by reducing platelet activation and downstream microvascular thrombosis in rats.

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2023 Feb 4

Cheng Q, Wang M, Jin R

163. Efficacy of ZnO nanoparticles in Zn fortification and partitioning of wheat and rice grains under salt stress.

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2023 Feb 4

Mazhar Z, Akhtar J, Alhodaib A

164. Influence of a transient spark plasma discharge on producing high molecular masses of chemical products from L-cysteine.

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2023 Feb 4

Farhadi M, Sohbatzadeh F.

165. Non-enzymatic disposable electrochemical sensors based on CuO/Co(3)O(4)@MWCNTs nanocomposite modified screen-printed electrode for the direct determination of urea.

Sci Rep

2023 Feb 4

Magar HS, Hassan RYA, Abbas MN.

166. Segmentation of mine overburden dump particles from images using Mask R CNN.

Sci Rep

2023 Feb 4

Shrivastava S, Bhattacharjee S, Deb D.

167. Face pareidolia is enhanced by 40 Hz transcranial alternating current stimulation (tACS) of the face perception network.

Sci Rep

2023 Feb 4

Palmisano A(#), Chiarantoni G(#), Bossi F

168. Impact of GAP-43, Cx43 and actin expression on the outcome and overall survival in diffuse and anaplastic gliomas.

Sci Rep

2023 Feb 4

Krigers A, Demetz M, Moser P

169. Caloric restriction increases the resistance of aged heart to myocardial ischemia/reperfusion injury via modulating AMPK-SIRT(1)-PGC(1a) energy metabolism pathway.

Sci Rep

2023 Feb 4

Guo Z(#), Wang M(#), Ying X

170. Radiomic phenotyping of the lung parenchyma in a lung cancer screening cohort.

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2023 Feb 4

Haghighi B, Horng H, Noël PB

High-throughput extraction of radiomic features from low-dose CT scans can characterize the heterogeneity of the lung parenchyma and potentially aid in identifying subpopulations that may have higher risk of lung diseases, such as COPD, and lung cancer due to inflammation or obstruction of the airways. We aim to determine the feasibility of a lung radiomics phenotyping approach in a lung cancer screening cohort, while quantifying the effect of different CT reconstruction algorithms on phenotype robustness. We identified low-dose CT scans (n = 308) acquired with Siemens Healthineers scanners from patients who completed low-dose CT within our lung cancer screening program between 2015 and 2018 and had two different sets of image reconstructions kernel available (i.e., medium (I30f.), sharp (I50f.)) for the same acquisition. Following segmentation of the lung field, a total of 26 radiomic features were extracted from the entire 3D lung-field using a previously validated fully-automated lattice-based software pipeline, adapted for low-dose CT scans. The lattice in-house software was used to extract features including gray-level histogram, co-occurrence, and run-length descriptors. The lattice approach uses non-overlapping windows for traversing along pixels of images and calculates different features. Each feature was averaged for each scan within a range of lattice window sizes (W) of 4, 8 and 20 mm. The extracted imaging features from both datasets were harmonized to correct for differences in image acquisition parameters. Subsequently, unsupervised hierarchical clustering was applied on the extracted features to identify distinct phenotypic patterns of the lung parenchyma, where consensus clustering was used to identify the optimal number of clusters (K = 2). Differences between phenotypes for demographic and clinical covariates including sex, age, BMI, pack-years of smoking, Lung-RADS and cancer diagnosis were assessed for each phenotype cluster, and then compared across clusters for the two different CT reconstruction algorithms using the cluster entanglement metric, where a lower entanglement coefficient corresponds to good cluster alignment. Furthermore, an independent set of low-dose CT scans (n = 88) from patients with available pulmonary function data on lung obstruction were analyzed using the identified optimal clusters to assess associations to lung obstruction and validate the lung phenotyping paradigm. Heatmaps generated by radiomic features identified two distinct lung parenchymal phenotype patterns across different feature extraction window sizes, for both reconstruction algorithms (P < 0.05 with K = 2). Associations of radiomic-based clusters with clinical covariates showed significant differences for BMI and pack-years of smoking (P < 0.05) for both reconstruction kernels. Radiomic phenotype patterns were more similar across the two reconstructed kernels, when smaller window sizes (W = 4 and 8 mm) were used for radiomic feature extraction, as deemed by their entanglement coefficient. Validation of clustering approaches using cluster mapping for the independent sample with lung obstruction also showed two statistically significant phenotypes (P < 0.05) with significant difference for BMI and smoking pack-years. Radiomic analysis can be used to characterize lung parenchymal phenotypes from low-dose CT scans, which appear reproducible for different reconstruction kernels. Further work should seek to evaluate the effect of additional CT acquisition parameters and validate these phenotypes in characterizing lung cancer screening populations, to potentially better stratify disease patterns and cancer risk.

171. Parametric study of pulsed nanosecond laser interaction with carbon-nanotube composite bipolar plate for PEMFCs.

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2023 Feb 4

Musse D, Lee D.

172. Association between urinary iodine concentration and the risk of papillary thyroid cancer by sex and age: a case-control study.

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2023 Feb 4

Hwang Y, Oh HK, Chung JH

173. Novel biosynthesis of MnO NPs using Mycoendophyte: industrial bioprocessing strategies and scaling-up production with its evaluation as anti-phytopathogenic agents.

Sci Rep

2023 Feb 4

El-Moslamy SH, Yahia IS, Zahran HY

174. The sleeping brain's connectivity and family environment: characterizing sleep EEG coherence in an infant cohort.

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2023 Feb 4

Markovic A, Schoch SF, Huber R

175. Clinical and sonographic impact of oral contraception in patients with deep endometriosis and adenomyosis at 2 years of follow-up.

Sci Rep

2023 Feb 4

Carrillo Torres P, Martínez-Zamora MÁ, Ros C

Nowadays, combined oral contraceptives (COCs) are successfully employed for the treatment of endometriosis (END) and adenomyosis (AD) in a large proportion of patients. However, literature focusing on the clinical and sonographic response to treatment in the long-term follow-up of patients with deep endometriosis (DE) and AD is scarce. The aim of this study was to evaluate the changes in the symptoms and the sonographic exams at 12 and 24 months of follow-up in patients who had received a flexible extended COC regimen containing 2 mg of dienogest/30 μg ethinyl estradiol. This prospective, longitudinal, observational study included women diagnosed with DE and AD presenting no surgical indication and were candidates to treatment with COCs. The presence and severity of dysmenorrhea, non-menstrual pelvic pain, deep dyspareunia, dyschezia and dysuria were evaluated using the Numerical Rating Scale (NRS) at baseline, and at 12 and 24 months of treatment. Transvaginal ultrasound was also performed at these check points searching for criteria of AD and reporting the size of the DE nodules and ovarian endometriomas (OE). Sixty-four patients were included. A significant decrease in the number of patients with severe dysmenorrhea and non-menstrual pelvic pain was reported during follow-up. The mean NRS score for dysmenorrhea, non-menstrual pelvic pain, deep dyspareunia, dyschezia and dysuria was also significantly lower at follow-up. There was a significant reduction in the sonographic number and type of AD criteria during follow-up after treatment. Similarly, a significant decrease in the size of OE and uterosacral ligament involvement in DE was observed at the 12-month follow-up, with a further, albeit not statistically significant, decrease in the 12- to 24-month follow-up. Additionally, torus and rectosigmoid DE decreased in size, although the reduction was not statistically significant at any study point. This prospective study suggests a clinical and sonographic improvement after a flexible extended COC regimen in DE and AD patients, which was significant at 12 months of follow-up. The improvement was more evident in AD and OEs compared with DE. Further research with a longer follow-up, larger sample size and comparison with other treatments is needed.

176. Comparing bound entanglement of bell diagonal pairs of qutrits and ququarts.

Sci Rep

2023 Feb 4

Popp C, Hiesmayr BC.

177. Red cabbage extract-mediated colorimetric sensor for swift, sensitive and economic detection of urease-positive bacteria by naked eye and Smartphone platform.

Sci Rep

2023 Feb 4

Celik C, Demir NY, Duman M

178. Mechanical performance and thermal stability of hardened Portland cement-recycled sludge pastes containing MnFe(2)O(4) nanoparticles.

Sci Rep

2023 Feb 4

Mohamed OA, El-Dek SI, El-Gamal SMA.

179. Incentive strategy of safe and intelligent production in assembled steel plants from the perspective of evolutionary game.

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2023 Feb 4

Wang Y, Chen L, Li Y

180. Energy management system in smart buildings based coalition game theory with fog platform and smart meter infrastructure.

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2023 Feb 4

Saeed MA, Eladl AA, Alhasnawi BN

181. A nonlinear viscoelastic constitutive model with damage and experimental validation for composite solid propellant.

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2023 Feb 4

Li H, Xu JS, Chen X

182. Combining thermal, tri-stereo optical and bi-static InSAR satellite imagery for lava volume estimates: the 2021 Cumbre Vieja eruption, La Palma.

Sci Rep

2023 Feb 4

Plank S, Shevchenko AV, d'Angelo P

183. Measurements and computational fluid dynamics investigation of the indoor radon distribution in a typical naturally ventilated room.

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2023 Feb 4

Adelikhah M, Imani M, Kovács T.

184. A numerical study on the relationship between the doping and performance in P3HT:PCBM organic bulk heterojunction solar cells.

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2023 Feb 4

Movla H(#), Shahalizad A, Asgari A(#).

185. Digital manufacturing of personalised footwear with embedded sensors.

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2023 Feb 3

Binelli MR(#), van Dommelen R(#), Nagel Y

186. Spatio-temporal numerical modeling of stochastic predator-prey model.

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2023 Feb 3

Yasin MW, Ahmed N, Iqbal MS

187. Engineered tissue vascularization and engraftment depends on host model.

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2023 Feb 3

Brady EL(#), Prado O(#), Johansson F

188. Anti-biofilm effects and healing promotion by silver oxynitrate-based dressings.

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2023 Feb 3

Doherty C, Byrne CV, Baqader S

189. Multimodal sensor fusion in the latent representation space.

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2023 Feb 3

Piechocki RJ, Wang X, Bocus MJ.

190. The impact of oxygen supply and erythrocytes during normothermic kidney perfusion.

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2023 Feb 3

von Horn C, Zlatev H, Lüer B

191. Effects of microplastics and surfactants on surface roughness of water waves.

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2023 Feb 3

Sun Y, Bakker T, Ruf C

192. Differentially expression analyses in fruit of cultivated and wild species of grape and peach.

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2023 Feb 3

Huang W(#), Li M(#), Zhang H

193. Lysine 222 in PPAR γ1 functions as the key site of MuRF2-mediated ubiquitination modification.

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2023 Feb 3

Fan Y(#), Xu F(#), Wang R

194. Integrative pathway and network analysis provide insights on flooding-tolerance genes in soybean.

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2023 Feb 3

Jhan LH, Yang CY, Huang CM

195. Immature and mature bone marrow-derived dendritic cells exhibit distinct intracellular mechanical properties.

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2023 Feb 3

Leblanc-Hotte A(#), Audiger C(#), Chabot-Roy G

196. DNA quality evaluation of formalin-fixed paraffin-embedded heart tissue for DNA methylation array analysis.

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2023 Feb 3

Dupont ME, Christiansen SN, Jacobsen SB

197. Self-association of the glycopeptide antibiotic teicoplanin A2 in aqueous solution studied by molecular hydrodynamics.

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2023 Feb 3

Chun T, Pattem J, Gillis RB

198. Evaluation of the portability of computable phenotypes with natural language processing in the eMERGE network.

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2023 Feb 3

Pacheco JA, Rasmussen LV, Wiley K Jr

199. Disease state associated with chronic toe lesions in hellbenders may alter anti-chytrid skin defenses.

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2023 Feb 3

Hardman RH, Reinert LK, Irwin KJ

200. TEMPRANILLO homologs in apple regulate flowering time in the woodland strawberry Fragaria vesca.

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2023 Feb 3

Dejahang A, Maghsoudi N, Mousavi A

201. Graphene-based optofluidic tweezers for refractive-index and size-based nanoparticle sorting, manipulation, and detection.

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2023 Feb 3

Gholizadeh E(#), Jafari B(#), Golmohammadi S.

This work proposes a novel design composed of graphene nanoribbons-based optofluidic tweezers to manipulate and sort bio-particles with radii below 2.5 nm. The suggested structure has been numerically investigated by the finite difference time domain (FDTD) method employing Maxwell's stress tensor analysis (MST). The finite element method (FEM) has been used to obtain the electrostatic response of the proposed structure. The tweezer main path is a primary channel in the center of the structure, where the microfluidic flow translates the nanoparticle toward this channel. Concerning the microfluid's drag force, the nanoparticles tend to move along the length of the main channel. The graphene nanoribbons are fixed near the main channel at different distances to exert optical forces on the moving nanoparticles in the perpendicular direction. In this regard, sub-channels embedding in the hBN layer on the Si substrate deviate bio-particles from the main path for particular nanoparticle sizes and indices. Intense hotspots with electric field enhancements up to 900 times larger than the incident light are realized inside and around the graphene ribbons. Adjusting the gap distance between the graphene nanoribbon and the main channel allows us to separate the individual particle with a specific size from others, thus guiding that in the desired sub-channel. Furthermore, we demonstrated that in a structure with a large gap between channels, particles experience weak field intensity, leading to a low optical force that is insufficient to detect, trap, and manipulate nanoparticles. By varying the chemical potential of graphene associated with the electric field intensity variations in the graphene ribbons, we realized tunability in sorting nanoparticles while structural parameters remained constant. In fact, by adjusting the graphene Fermi level via the applied gate voltage, nanoparticles with any desired radius will be quickly sorted. Moreover, we exhibited that the proposed structure could sort nanoparticles based on their refractive indices. Therefore, the given optofluidic tweezer can easily detect bio-particles, such as cancer cells and viruses of tiny size.

202. Machine learning to improve frequent emergency department use prediction: a retrospective cohort study.

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2023 Feb 3

Chiu YM, Courteau J, Dufour I

Frequent emergency department use is associated with many adverse events, such as increased risk for hospitalization and mortality. Frequent users have complex needs and associated factors are commonly evaluated using logistic regression. However, other machine learning models, especially those exploiting the potential of large databases, have been less explored. This study aims at comparing the performance of logistic regression to four machine learning models for predicting frequent emergency department use in an adult population with chronic diseases, in the province of Quebec (Canada). This is a retrospective population-based study using medical and administrative databases from the Régie de l'assurance maladie du Québec. Two definitions were used for frequent emergency department use (outcome to predict): having at least three and five visits during a year period. Independent variables included sociodemographic characteristics, healthcare service use, and chronic diseases. We compared the performance of logistic regression with gradient boosting machine, naïve Bayes, neural networks, and random forests (binary and continuous outcome) using Area under the ROC curve, sensibility, specificity, positive predictive value, and negative predictive value. Out of 451,775 ED users, 43,151 (9.5%) and 13,676 (3.0%) were frequent users with at least three and five visits per year, respectively. Random forests with a binary outcome had the lowest performances (ROC curve: 53.8 [95% confidence interval 53.5-54.0] and 51.4 [95% confidence interval 51.1-51.8] for frequent users 3 and 5, respectively) while the other models had superior and overall similar performance. The most important variable in prediction was the number of emergency department visits in the previous year. No model outperformed the others. Innovations in algorithms may slightly refine current predictions, but access to other variables may be more helpful in the case of frequent emergency department use prediction.

203. Genome-wide transcriptional response of Escherichia coli O157:H7 to light-emitting diodes with various wavelengths.

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2023 Feb 3

Khan SA, Kim MJ, Yuk HG.

204. Enhanced bacterial clearance in early secondary sepsis in a porcine intensive care model.

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2023 Feb 3

Wilske F(#), Skorup P(#), Hanslin K

205. The effects of being told you are in the intervention group on training results: a pilot study.

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2023 Feb 3

Lindberg K, Bjørnsen T, Vårvik FT

206. Emotional and behavioral changes in French children during the COVID-19 pandemic: a retrospective study.

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2023 Feb 3

Landman B, Cohen A, Khoury E

207. A circulating microRNA panel as a novel dynamic monitor for oral squamous cell carcinoma.

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2023 Feb 3

Piao Y, Jung SN, Lim MA

208. Yoghurt as a deglutition aid for oral medication: effects on famotidine powder dissolution rate and pharmacokinetics.

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2023 Feb 3

Gotoh Y, Tabata Y, Sugiura S

209. Gut microbial signature in lung cancer patients highlights specific taxa as predictors for durable clinical benefit.

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2023 Feb 3

Haberman Y, Kamer I, Amir A

210. Computational fluid-structure interaction analysis of flapping uvula on aerodynamics and pharyngeal vibration in a pediatric airway.

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2023 Feb 3

Chen Y, Feng X, Shi XQ

211. Clinical relevance of leukocyte-associated endotoxins measured by semi-automatic synthetic luminescent substrate method.

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2023 Feb 3

Terayama M, Takahashi G, Nonoguchi M

212. Limitation of convergence-confinement method on three-dimensional tunnelling effect.

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2023 Feb 3

Chang L, Alejano LR, Cui L

213. Differential gene expression analysis using RNA-seq in the blood of goats exposed to transportation stress.

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2023 Feb 3

Naldurtiker A, Batchu P, Kouakou B

214. Visibility of early gastric cancers by texture and color enhancement imaging using a high-definition ultrathin transnasal endoscope.

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2023 Feb 3

Koyama Y, Sugimoto M, Kawai T

215. Solving large-scale discrete time-cost trade-off problem using hybrid multi-verse optimizer model.

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2023 Feb 3

Son PVH, Nguyen Dang NT.

216. Local IL-10 delivery modulates the immune response and enhances repair of volumetric muscle loss muscle injury.

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2023 Feb 3

Huynh T, Reed C, Blackwell Z

217. The effect of mindfulness-based intervention on neurobehavioural functioning and its association with white-matter microstructural changes in preterm young adolescents.

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2023 Feb 3

Siffredi V, Liverani MC, Van De Ville D

218. The post-conflict expansion of coca farming and illicit cattle ranching in Colombia.

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2023 Feb 3

Murillo-Sandoval PJ, Kilbride J, Tellman E

219. Narrowing the coordination solution space during motor learning standardizes individual patterns of search strategy but diversifies learning rates.

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2023 Feb 3

Komar J, Seifert L, Vergne N

220. Entropy optimization and heat flux analysis of Maxwell nanofluid configurated by an exponentially stretching surface with velocity slip.

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2023 Feb 3

Nasir S, Berrouk AS, Aamir A

221. Fabrication of biochar derived from different types of feedstocks as an efficient adsorbent for soil heavy metal removal.

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2023 Feb 3

Burachevskaya M, Minkina T, Bauer T

For effective soil remediation, it is vital to apply environmentally friendly and cost-effective technologies following the notion of green sustainable development. In the context of recycling waste and preserving nutrients in the soil, biochar production and utilization have become widespread. There is an urgent need to develop high-efficiency biochar-based sorbents for pollution removal from soil. This research examined the efficacy of soil remediation using biochar made from three distinct sources: wood, and agricultural residues (sunflower and rice husks). The generated biochars were characterized by SEM/SCEM, XRF, XRD, FTIR, BET Specific Surface Area, and elemental compositions. The presence of hydroxyl and phenolic functional groups and esters in wood, sunflower and rice husk biochar were noted. The total volume of pores was in the following descending order: rice husk > wood > sunflower husk. However, wood biochar had more thermally stable, heterogeneous, irregular-shaped pores than other samples. Adsorption of soil-heavy metals into biochars differed depending on the type of adsorbent, according to data derived from distribution coefficients, sorption degree, Freundlich, and Langmuir adsorption models. The input of biochars to Calcaric Fluvic Arenosol increased its adsorption ability under contamination by Cu(II), Zn(II), and Pb(II) in the following order: wood > rice husk > sunflower husk. The addition of sunflower husk, wood, and rice husk biochar to the soil led to an increase in the removal efficiency of metals in all cases (more than 77%). The increase in the percentage adsorption of Cu and Pb was 9-19%, of Zn was 11-21%. The present results indicated that all biochars functioned well as an absorbent for removing heavy metals from soils. The tailor-made surface chemistry properties and the high sorption efficiency of the biochar from sunflower and rice husks could potentially be used for soil remediation.

222. Physical and psychosocial factors associated with sexual satisfaction in long-term cancer survivors 5 and 10 years after diagnosis.

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2023 Feb 3

Heyne S, Taubenheim S, Dietz A

223. De novo transcriptome assembly from the nodal root growth zone of hydrated and water-deficit stressed maize inbred line FR697.

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2023 Feb 3

Sen S, King SK, McCubbin T

224. Evaluation of the risk of SARS-CoV-2 infection and hospitalization in vaccinated and previously infected subjects based on real world data.

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2023 Feb 3

Rossi MA, Cena T, Binala J

225. Different effects of pesticides on transcripts of the endocrine regulation and energy metabolism in honeybee foragers from different colonies.

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2023 Feb 3

Christen V.

Honeybees are important pollinators of many crops and contribute to biological biodiversity. For years, a decline in bee populations has been observed in certain areas. This decline in honeybees is accompanied by a decrease in pollinator services. One factor contributing to the decline of bee colonies is the exposure to pesticides. Pesticide exposure of bees, among other effects, can negatively affect orientation, memory, immune system function and gene expression. Among the altered expressed genes are transcripts of endocrine regulation and oxidative phosphorylation. Endocrine regulation plays an important role in the development of nurse bees into foragers and oxidative phosphorylation is involved in energy metabolism. Most of these transcriptional changes were investigated using mixed aged honeybees derived from the same colony. Experiments using nurse bees or foragers of the same age but from different colonies are rare. In the present study, effects of the two pesticides chlorpyrifos and pyraclostrobin on the expression of transcripts linked to endocrine regulation and oxidative phosphorylation in foragers of the same age from three different colonies are investigated to fill this gap. These two pesticides were selected because negative effects at sublethal concentrations on bees are known and because they are found in pollen and nectar of crops and wild plants. For this purpose, 20-22 days old foragers of three different colonies were exposed to different sublethal concentrations of the selected fungicides for 24 h, followed by analysis of the expression of buffy, vitellogenin, hbg-3, ilp-1, mrjp1, 2 and 3, cox5a, cox5b and cox17. Some significant changes in gene expression of both endocrine regulation transcripts and oxidative phosphorylation were shown. Furthermore, it became clear that forager bees from different colonies react differently. This is especially important in relation to the risk analysis of pesticides. In addition, it could be shown that the expression of hbg-3 in the brain of bees is a robust marker to distinguish nurse bees from foragers at the molecular biological level. In summary, this study clearly shows that pesticides, which are often detected in pollen and nectar, display negative effects at sublethal concentrations on bees and that it is important to use bees from different colonies for risk assessment of pesticides.

226. Laboratory protocol is important to improve the correlation between target copies and metabarcoding read numbers of seed DNA in ground beetle regurgitates.

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2023 Feb 3

Neidel V, Traugott M.

227. Influence of pneumatization on morphology of temporal bone-related vasculatures and their morphometric relationship with ear regions: a computed tomography study.

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2023 Feb 3

Aladeyelu OS, Olojede SO, Lawal SK

228. Yield, growth development and grain characteristics of seven Quinoa (Chenopodium quinoa Willd.) genotypes grown in open-field production systems under hot-arid climatic conditions.

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2023 Feb 3

Oustani M, Mehda S, Halilat MT

229. Combining accelerometers and direct visual observations to detect sickness and pain in cows of different ages submitted to systemic inflammation.

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2023 Feb 3

Ledoux D, Veissier I, Meunier B

230. Exploring finite temperature properties of materials with quantum computers.

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2023 Feb 3

Powers C, Bassman Oftelie L, Camps D

231. The effect of temporal expectation on the correlations of frontal neural activity with alpha oscillation and sensory-motor latency.

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2023 Feb 3

Lee J.

232. Simulation-based architecture of a stable large-area [Formula: see text] atmospheric plasma source.

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2023 Feb 3

Roshan MV, Razaghi S, Singh A.

233. Magnetic bentonite decorated with Pd nanoparticles and cross-linked polyvinyl pyridine as an efficient nanocatalyst for Suzuki coupling and 4-Nitrophenol reduction reactions.

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2023 Feb 3

Daneshafruz H, Mohammadi P, Barani H

234. Estimation of dye concentration by using Kubelka-Munk and Allen-Goldfinger reflective models: comparing the performance.

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2023 Feb 3

Safi M, Amirshahi SH.

235. Evaluating the effects of giraffe skin disease and wire snare wounds on the gaits of free-ranging Nubian giraffe.

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2023 Feb 3

Bernstein-Kurtycz LM, Dunham NT, Evenhuis J

Giraffe skin disease (GSD), a condition that results in superficial lesions in certain giraffe (Giraffa spp.) populations, has emerged as a potential conservation threat. Preliminary findings suggested that individuals with GSD lesions move with greater difficulty which may in turn reduce their foraging efficiency or make them more vulnerable to predation. A current known threat to some giraffe populations is their mortality associated with entrapment in wire snares, and the morbidity and potential locomotor deficiencies associated with wounds acquired from snares. The goal of our study was to quantify the locomotor kinematics of free-ranging Nubian giraffe (G. camelopardalis camelopardalis) in Murchison Falls National Park (MFNP), Uganda, and compare spatiotemporal limb and neck angle kinematics of healthy giraffe to those of giraffe with GSD lesions, snare wounds, and both GSD lesions and snare wounds. The presence of GSD lesions did not significantly affect spatiotemporal limb kinematic parameters. This finding is potentially because lesions were located primarily on the necks of Nubian giraffe in MFNP. The kinematic parameters of individuals with snare wounds differed from those of healthy individuals, resulting in significantly shorter stride lengths, reduced speed, lower limb phase values, and increased gait asymmetry. Neck angle kinematic parameters did not differ among giraffe categories, which suggests that GSD neck lesions do not impair normal neck movements and range of motion during walking. Overall, MFNP giraffe locomotor patterns are largely conservative between healthy individuals and those with GSD, while individuals with snare wounds showed more discernible kinematic adjustments consistent with unilateral limb injuries. Additional studies are recommended to assess spatiotemporal limb kinematics of giraffe at sites where lesions are found predominantly on the limbs to better assess the potential significance of GSD on their locomotion.

236. Research on blasting cumulative dynamic damage of surrounding rock in step construction tunnel.

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2023 Feb 3

Cui Y, Wu B, Meng G

237. Development of a treatment for water contaminated with Cr (VI) using cellulose xanthogenate from E. crassipes on a pilot scale.

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2023 Feb 3

Sayago UFC, Ballesteros Ballesteros V.

238. Exploring the impact of temperature and oxygen partial pressure on the spent nuclear fuel oxidation during its dry management.

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2023 Feb 3

Milena-Pérez A, Bonales LJ, Rodríguez-Villagra N

239. Dynamics of fatty acid and non-volatile polar metabolite profiles in colostrum and milk depending on the lactation stage and parity number of sows.

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2023 Feb 3

Settachaimongkon S, Homyog K, Mekboonsonglarp W

240. A micromechanical study on the effects of precipitation on the mechanical properties of CoCrFeMnNi high entropy alloys with various annealing temperatures.

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2023 Feb 28

Huang CW, Su PY, Yu CH

241. UCHL1, besides leptin and fibronectin, also could be a sensitive marker of the relapsing-remitting type of multiple sclerosis.

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2023 Feb 28

Górska E(#), Tylicka M(#), Hermanowicz A

242. Cortical atrophy in chronic subdural hematoma from ultra-structures to physical properties.

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2023 Feb 28

Familiari P(#), Lapolla P(#), Relucenti M

Several theories have tried to elucidate the mechanisms behind the pathophysiology of chronic subdural hematoma (CSDH). However, this process is complex and remains mostly unknown. In this study we performed a retrospective randomised analysis comparing the cortical atrophy of 190 patients with unilateral CSDH, with 190 healthy controls. To evaluate the extent of cortical atrophy, CT scan images were utilised to develop an index that is the ratio of the maximum diameter sum of 3 cisterns divided by the maximum diameter of the skull at the temporal lobe level. Also, we reported, for the first time, the ultrastructural analyses of the CSDH using a combination of immunohistochemistry methods and transmission electron microscopy techniques. Internal validation was performed to confirm the assessment of the different degrees of cortical atrophy. Relative Cortical Atrophy Index (RCA index) refers to the sum of the maximum diameter of three cisterns (insular cistern, longitudinal cerebral fissure and cerebral sulci greatest) with the temporal bones' greatest internal distance. This index, strongly related to age in healthy controls, is positively correlated to the preoperative and post-operative maximum diameter of hematoma and the midline shift in CSDH patients. On the contrary, it negatively correlates to the Karnofsky Performance Status (KPS). The Area Under the Receiver Operating Characteristics (AUROC) showed that RCA index effectively differentiated cases from controls. Immunohistochemistry analysis showed that the newly formed CD-31 positive microvessels are higher in number than the CD34-positive microvessels in the CSDH inner membrane than in the outer membrane. Ultrastructural observations highlight the presence of a chronic inflammatory state mainly in the CSDH inner membrane. Integrating these results, we have obtained an etiopathogenetic model of CSDH. Cortical atrophy appears to be the triggering factor activating the cascade of transendothelial cellular filtration, inflammation, membrane formation and neovascularisation leading to the CSDH formation.

243. Spin-flip-driven anomalous Hall effect and anisotropic magnetoresistance in a layered Ising antiferromagnet.

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2023 Feb 28

Oh DG(#), Kim JH(#), Kim MK

244. Comparison of portal vein hemodynamics with ultrasound-based elastography for the prediction of liver fibrosis in patients with chronic liver disease.

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2023 Feb 28

Yamaguchi K, Seko Y, Sakai T

245. Assortativity in cognition.

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2023 Feb 28

Bilancini E(#), Boncinelli L(#), Vicario E(#).

246. Prenatal genetic analysis of fetal aberrant right subclavian artery with or without additional ultrasound anomalies in a third level referral center.

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2023 Feb 28

Xue H(#), Zhang L(#), Yu A(#)

247. Orange peels magnetic activate carbon (MG-OPAC) composite formation for toxic chromium absorption from wastewater.

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2023 Feb 28

Khalil A, Salem M, Ragab S

248. Exploring the diagnostic value of eosinophil-to-lymphocyte ratio to differentiate Kawasaki disease from other febrile diseases based on clinical prediction model.

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2023 Feb 28

Guo X(#), Liao J(#), Fan X

249. Rescuing cellular function in Fuchs endothelial corneal dystrophy by healthy exogenous mitochondrial internalization.

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2023 Feb 28

Méthot S, Proulx S, Brunette I

250. Contributions of NR1H3 genetic polymorphisms to susceptibility and effects of narrowband UVB phototherapy to nonsegmental vitiligo.

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2023 Feb 28

Xu M(#), Xu Q(#), Liu Y

251. A clustering linear combination method for multiple phenotype association studies based on GWAS summary statistics.

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2023 Feb 28

Wang M, Cao X, Zhang S

252. Papaver somniferum in seventeenth century (Italy): archaeotoxicological study on brain and bone samples in patients from a hospital in Milan.

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2023 Feb 28

Giordano G(#), Mattia M(#), Biehler-Gomez L

253. Silver nanoparticles and platelet-rich fibrin accelerate tendon healing in donkey.

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2023 Feb 28

Abdelhakiem MAH, Hussein A, Seleim SM

254. Interconnected hydrologic extreme drivers and impacts depicted by remote sensing data assimilation.

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2023 Feb 28

Lahmers TM, Kumar SV, Locke KA

255. Effect of cavity shape on microstructural evolution of pure aluminum in electrically-assisted solidification.

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2023 Feb 28

Choi SJ, Kim D, La M

256. A new method for ferroresonance suppression in an IEEE 33-bus distribution system integrated with multi distributed generation.

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2023 Feb 28

Abdel-Hamed AM, El-Shafhy MM, Badran EA.

257. Effect of oxygen vacancy and highly dispersed MnO(x) on soot combustion in cerium manganese catalyst.

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2023 Feb 28

Zhu Y, Chen Z, Li H

258. Structural controllability of general edge dynamics in complex network.

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2023 Feb 28

Pang S, Zhou Y, Ren X

259. Bio-physiological susceptibility of the brain, heart, and lungs to systemic ischemia reperfusion and hyperoxia-induced injury in post-cardiac arrest rats.

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2023 Feb 28

Aoki T, Wong V, Endo Y

Cardiac arrest (CA) patients suffer from systemic ischemia-reperfusion (IR) injury leading to multiple organ failure; however, few studies have focused on tissue-specific pathophysiological responses to IR-induced oxidative stress. Herein, we investigated biological and physiological parameters of the brain and heart, and we particularly focused on the lung dysfunction that has not been well studied to date. We aimed to understand tissue-specific susceptibility to oxidative stress and tested how oxygen concentrations in the post-resuscitation setting would affect outcomes. Rats were resuscitated from 10 min of asphyxia CA. Mechanical ventilation was initiated at the beginning of cardiopulmonary resuscitation. We examined animals with or without CA, and those were further divided into the animals exposed to 100% oxygen (CA_Hypero) or those with 30% oxygen (CA_Normo) for 2 h after resuscitation. Biological and physiological parameters of the brain, heart, and lungs were assessed. The brain and lung functions were decreased after CA and resuscitation indicated by worse modified neurological score as compared to baseline (222 ± 33 vs. 500 ± 0, P < 0.05), and decreased PaO2 (20 min after resuscitation: 113 ± 9 vs. baseline: 128 ± 9 mmHg, P < 0.05) and increased airway pressure (2 h: 10.3 ± 0.3 vs. baseline: 8.1 ± 0.2 mmHg, P < 0.001), whereas the heart function measured by echocardiography did not show significant differences compared before and after CA (ejection fraction, 24 h: 77.9 ± 3.3% vs. baseline: 82.2 ± 1.9%, P = 0.2886; fractional shortening, 24 h: 42.9 ± 3.1% vs. baseline: 45.7 ± 1.9%, P = 0.4658). Likewise, increases of superoxide production in the brain and lungs were remarkable, while those in the heart were moderate. mRNA gene expression analysis revealed that CA_Hypero group had increases in Il1b as compared to CA_Normo group significantly in the brain (P < 0.01) and lungs (P < 0.001) but not the heart (P = 0.4848). Similarly, hyperoxia-induced increases in other inflammatory and apoptotic mRNA gene expression were observed in the brain, whereas no differences were found in the heart. Upon systemic IR injury initiated by asphyxia CA, hyperoxia-induced injury exacerbated inflammation/apoptosis signals in the brain and lungs but might not affect the heart. Hyperoxia following asphyxia CA is more damaging to the brain and lungs but not the heart.

260. Efficacy and safety of angiogenesis inhibitors plus immune checkpoint inhibitors in advanced soft tissue sarcoma: a real-world, single-center study.

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2023 Feb 28

Liu Z(#), Xu J(#), Liu M

261. A radioanatomical study of 3rd segment terminal branches of the maxillary artery in the pterygopalatine fossa.

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2023 Feb 28

Lovász K, Magyar P, Szalóki T

262. Unsupervised anomaly detection for posteroanterior chest X-rays using multiresolution patch-based self-supervised learning.

Sci Rep

2023 Feb 28

Kim M(#), Moon KR(#), Lee BD.

263. Astragalus-cultivated soil was a suitable bed soil for nurturing Angelica sinensis seedlings from the rhizosphere microbiome perspective.

Sci Rep

2023 Feb 28

An ZG, Guo FX, Chen Y

264. PAMAM-G4 protect the N-(2-hydroxyphenyl)-2-propylpentanamide (HO-AAVPA) and maintain its antiproliferative effects on MCF-7.

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2023 Feb 28

Ortiz-Morales AA, García-Vázquez JB, Fragoso-Vázquez MJ

265. Potential benefits of a blend of essential oils on metabolism, digestibility, organ development and gene expression of dairy calves.

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2023 Feb 28

Campolina JP, Coelho SG, Belli AL

The objective of this study was to evaluate blood cells and metabolites, insulin-like growth factor-1 (IGF-1), digestibility, internal organs weight and histology, gene expression, and spleen cell proliferation of pre-weaned bull calves supplemented with a blend of essential oils in milk replacer (MR). Sixteen newborn Holstein × Gyr crossbred dairy bull calves, with body weight at birth of 33.3 ± 3.7 kg, were housed in individual sand bedded pens, blocked by genetic composition, and randomly assigned to 1 of 2 treatments in a randomized complete block design: Control (CON, n = 8) and blend of essential oils supplementation (BEO, n = 8, 1 g/day/calf, Apex Calf, Adisseo, China). The commercial blend was composed by plant extracts derived from anise, cinnamon, garlic, rosemary, and thyme. Animals were fed 5 L of MR/day reconstituted at 15% (dry matter basis), divided into two equal meals. Water and starter were provided ad libitum. ß-hydroxybutyrate, urea, and glucose were evaluated weekly, IGF-1 was evaluated biweekly, and total blood cell count was performed every four weeks until the end of the trial at eight weeks of age. Feed samples were collected three times a week and polled for weekly analysis. Apparent total nutrient digestibility was determined from d 56 to 60 of age. On d 60 ± 1, animals were euthanized for organ weight, histology, spleen cell proliferation, and intestinal gene expression analysis. Data were analyzed independently using linear mixed models using the REML method in the nlme package in R for continuous outcomes. A non-parametric test was used for ordered categorical outcomes using the Artools package in R. There were no differences between groups for blood evaluations, digestibility, gene expression, and a spleen cell proliferation assay. However, BEO calves presented a heavier pancreas, heavier intestines, bigger ileum villi, and higher cecum butyrate levels (P < 0.05), demonstrating that the EO supplementation helped intestinal development and symbiotic bacteria. It was also observed in CON animals' heavier respiratory tract and a higher eosinophil count (P < 0.05). Therefore, the organs where eosinophils are more active had a better response for BEO animals. No differences were found in the intestinal gene expression in the immune context. These results demonstrate that supplementing essential oils in MR could contribute to gut development and immune function. However, more research is needed to understand its impact on body development and define the best dosage and route of administration.

266. Bellows stiffness characteristics of cord-reinforced air spring with winding formation under preload conditions.

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2023 Feb 28

Cheng YQ, Gao H, Shuai CG.

267. Novel biomarkers for neoplastic progression from ulcerative colitis to colorectal cancer: a systems biology approach.

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2023 Feb 28

Shahnazari M, Afshar S, Emami MH

In recent studies, the void of evaluation and in-depth understanding of unknown clinically relevant potential molecular biomarkers involved in colorectal cancer (CRC) from the inflammatory stage of ulcerative colitis (UC) to CRC metastasis, which can be suitable therapeutic targets, is deeply felt. The regulation and interaction among different cancer-promoting molecules, including messenger RNAs (mRNAs) and micro RNAs (miRNAs) in CRC and its progression, were the aim we pursued in this study. Using microarray data, we investigated the differential expression for five datasets, including mRNA and microRNA samples related to UC, tumor/normal. Then, using robust data analysis, separate lists of differentially expressed genes (DEGs) and differentially expressed miRNAs (DEmiRNAs) were identified, which were used for robust rank aggregation (RRA) and co-expression network analysis. Then, comprehensive computational systems biology analyses, including gene ontology and Kyoto encyclopedia of genes and genomic pathway enrichment analyses, mRNA-miRNA regulatory network, and survival analysis, were employed to achieve the aim of this study. Finally, we used clinical samples to validate this potential and new target. According to this systems biology approach, a total of 98 DEGs and 8 DEmiRNAs with common differential expression were identified. By combining the distinct results of RRA and network, several potential therapeutic targets, and predictive and prognostic biomarkers for UC and CRC were identified. These targets include six common hub genes, CXCL1, CXCL8, MMP7, SLCA16A9, PLAU, and TIMP1, which are upregulated. Among these, the important and new biomarker SLC16A9 is negatively regulated by hsa-mir-194-5p, and hsa-miR-378a-5p take. The findings of the present study provide new insight into the pathogenesis of CRC in UC. Our study suggests future evaluation of the functional role of SLC16A9 and hsa-mir-194-5p and hsa-miR-378a-5p in CRC development.

268. Rapid diagnosis of membranous nephropathy based on serum and urine Raman spectroscopy combined with deep learning methods.

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2023 Feb 28

Zhang X, Song X, Li W

269. Endoscopic image-guided laser treatment system based on fiber bundle laser steering.

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2023 Feb 28

Miyoshi Y(#), Nishimura T(#), Shimojo Y

270. Cdk5 mediates rotational force-induced brain injury.

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2023 Feb 28

Umfress A, Chakraborti A, Priya Sudarsana Devi S

271. Changes in clinicomorphometrical findings, lipid profiles, hepatorenal indices and oxidant/antioxidant status as thermoregulatory adaptive mechanisms in poikilothermic Dabb lizard (Uromastyx aegyptia).

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2023 Feb 28

Abdelghffar EAR, ALmohammadi AG, Malik S

Wildlife has exposed to various environmental stressors. Reptiles (ectothermic) are highly susceptible to climatic changes due to their behaviour, physiology, and life history that were so heavily reliant on the ambient environmental temperature. The present work aims to monitor different biochemical and haematological indices of Dabb lizards (Uromastyx aegyptia) at various thermal gradients as well as their adaptation to oxidative stress. This has been reflected through assessment of their impact on some adaptive physiological traits i.e. thermoregulation, and muscle metabolic biomarkers, blood pictures and oxidant/antioxidant status. This experiment is carried out on non-hibernating adult male Dabb lizards (U. aegyptia; n = 24) of age of 18-24 months. These Dabb lizards are divided into four equal groups (n = 6 for each one) where they are exposed to different thermal treatments for one week as following; control group [Exposed to terrarium temperature 38-39 °C], low temperature exposed group [Exposed to 12-14 °C], Gp. C; moderate temperature exposed group [Exposed to 41-43 °C] and high temperature exposed group [Exposed to 43-45 °C]. Each independent group (n = 6) are kept at separated glass terraria. The investigated lizards are monitored for body temperature, morphometric measurements i.e. body weight (g) and total body length (cm; TBL), muscle biochemical analysis, haematological pictures indices and serum biochemical assays including mainly oxidant/antioxidants biomarkers throughout the current experiment. The results state that the thermoregulatory behaviour of Dabb varies with the increase of concentration of muscular metabolic enzymes. In low temperature exposed group, the increase in red blood corpuscles (RBCs), haemoglobin concentrations (Hb), white blood cell (WBC), serum antioxidant biomarkers and anaerobic Lactate dehydrogenase (LDH) enzyme are associated with a marked reduction in serum levels of total cholesterol (TC), triglycerides (TGs), total proteins (TPs), albumin, glucose and electrolytes. In moderate temperature exposed group, a significant elevation in serum values of TC, TGs, TPs, glucose, urea and uric acids levels are mentioned. In high temperature exposed Dabb group, a remarkable increase in blood values of RBCs, Hb, haematocrit value (HCT), WBC, T. chol., TGs, TPs, glucose, urea, uric acids, triiodothyronine (T3) and thyroxine (T4) levels are also observed. Moreover, significant increases in muscular anaerobic/aerobic metabolic enzymes as well as stimulation of antioxidant defence system have been reported. Different significant correlations have been stated between variably estimated laboratory indices in the investigated Dabb lizards under different thermal treatments. The study concludes that the Dabb lizards have a strong antioxidant defence system and undergo physiological thermoregulatory adaptive mechanisms, that involve biochemical and metabolic acclimatization as a response to environmental temperature changes that act as a protective mechanism against oxidative stress as well as maintained homeostatic responses and normal physiological functions.

272. Spectroscopic identification of Ca-bearing uranyl silicates formed in C-S-H systems.

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2023 Feb 28

Yorkshire AS, Stennett MC, Walkley B

273. Applying machine learning methods to enable automatic customisation of knee replacement implants from CT data.

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2023 Feb 27

Burge TA, Jeffers JRT, Myant CW.

274. Effects of mammalian sex hormones on in vitro organogenesis of common bean (Phaseolus vulgaris L.).

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2023 Feb 27

Haliloğlu K, Türkoğlu A, Balpınar Ö

Beans are an important plant species and are one of the most consumed legumes in human nutrition, especially as a protein, vitamin, mineral, and fiber source. Common bean (Phaseolus vulgaris L.) is a plant that also has an important role in natural nitrogen fixation. Currently, in vitro regeneration and micropropagation applications are limited in relation to genetic factors in bean Accordingly, there is great need to optimize micropropagation and tissue culture methods of the bean plant. To date, the effect of mammalian sex hormones (MSH) on in vitro conditions in P. vulgaris L. is poorly understood. This study examined the effects of different types of explants (embryo, hypocotyl, plumule, and radicle), MSH type (progesterone, 17 β-estradiol, estrone, and testosterone), and MSH concentration (10-4, 10-6, 10-8 and 10-10 mmol L-1) on the responding explants induction rate (REI), viability of plantlets rate (VPR), shoot proliferation rate (SPR), root proliferation rate (RPR), and callus induction rate (CIR). The effects of mammalian sex hormones, concentrations, explant type, and their interactions were statistically significant (p ≤ 0.01) in all examined parameters. The best explants were embryo and plumule. Our results showed that the highest REI rate (100%) was recorded when 10-10 mmol L-1 of all MSH was applied to MS medium using the plumule explant. The highest VPR (100%) was obtained when 10-10 mmol L-1 of all MSH was applied to MS medium using the plumule explant. The highest root proliferation rates (77.5%) were recorded in MS medium supplemented with 10-8 mmol L-1 17β-estradiol using embryo explant. The highest percentage of shoot-forming explants (100%) generally was obtained from embryo and plumule cultured in the MS culture medium with low MSH concentration. In addition, the highest CIR (100%) was obtained from embryo and plumule explant cultured in MS medium containing 10-10 mmol L-1 of all MSH types. In conclusion, we observed that mammalian sex hormones may be used in bean in vitro culture.

275. Days alive and out of hospital at 30 days and outcomes of off-pump coronary artery bypass grafting.

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2023 Feb 27

Oh AR(#), Lee SH(#), Park J

276. An alternate hybrid PWM for uniform thermal sharing in single phase voltage-source inverter.

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2023 Feb 27

Kiranmai KSP(#), Damodaran RV(#), Hushki M

277. Spherical PEG/SiO(2) promising agents for Lamivudine antiviral drug delivery, a molecular dynamics simulation study.

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2023 Feb 27

Razzaghi S, Vafaee M, Kharazian B

278. Sleep duration during the COVID-19 pandemic in Bangladesh: A GIS-based large sample survey study.

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2023 Feb 27

Al-Mamun F, Hussain N, Sakib N

279. Remote-refocusing light-sheet fluorescence microscopy enables 3D imaging of electromechanical coupling of hiPSC-derived and adult cardiomyocytes in co-culture.

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2023 Feb 27

Dvinskikh L, Sparks H, Brito L

280. Patient profile, management, and quality of life associated with Dravet syndrome: a cross-sectional, multicentre study of 80 patients in Spain.

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2023 Feb 27

Gil-Nagel A, Sánchez-Carpintero R, Villanueva V.

281. Predicting anti-cancer activity in flavonoids: a graph theoretic approach.

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2023 Feb 27

Mukwembi S, Nyabadza F.

282. Development of a novel ex vivo organ culture system to improve preservation methods of regenerative tissues.

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2023 Feb 27

Yuta T(#), Tian T(#), Chiba Y

283. Research on the flow experience and social influences of users of short online videos. A case study of DouYin.

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2023 Feb 27

Zheng C.

284. Nine patients with KCNQ2-related neonatal seizures and functional studies of two missense variants.

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2023 Feb 27

Chokvithaya S, Caengprasath N, Buasong A

285. Repeatability and reproducibility of cardiac manganese-enhanced magnetic resonance imaging.

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2023 Feb 27

Singh T, Joshi S, Meah MN

286. A new and accurate qPCR protocol to detect plant pathogenic bacteria of the genus 'Candidatus Liberibacter' in plants and insects.

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2023 Feb 27

de Chaves MQ(#), Morán F(#), Barbé S

287. Investigation of V/III ratio dependencies for optimizing AlN growth during reduced parasitic reaction in metalorganic vapor phase epitaxy.

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2023 Feb 27

Tomita A, Miyagawa T, Hirayama H

288. The catalytic performance of CuFe(2)O(4)@CQD nanocomposite as a high-perform heterogeneous nanocatalyst in nitroaniline group reduction.

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2023 Feb 27

Naghash-Hamed S, Arsalani N, Mousavi SB.

289. Investigation on CMB monopole and dipole using blackbody radiation inversion.

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2023 Feb 27

Dhal S, Paul RK.

290. Using machine learning with optical profilometry for GaN wafer screening.

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2023 Feb 27

Gallagher JC, Mastro MA, Ebrish MA

291. Frailty and pain in an acute private hospital: an observational point prevalence study.

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2023 Feb 27

Saunders R, Crookes K, Seaman K

Frailty and pain in hospitalised patients are associated with adverse clinical outcomes. However, there is limited data on the associations between frailty and pain in this group of patients. Understanding the prevalence, distribution and interaction of frailty and pain in hospitals will help to determine the magnitude of this association and assist health care professionals to target interventions and develop resources to improve patient outcomes. This study reports the point prevalence concurrence of frailty and pain in adult patients in an acute hospital. A point prevalence, observational study of frailty and pain was conducted. All adult inpatients (excluding high dependency units) at an acute, private, 860-bed metropolitan hospital were eligible to participate. Frailty was assessed using the self-report modified Reported Edmonton Frail Scale. Current pain and worst pain in the last 24 h were self-reported using the standard 0-10 numeric rating scale. Pain scores were categorised by severity (none, mild, moderate, severe). Demographic and clinical information including admitting services (medical, mental health, rehabilitation, surgical) were collected. The STROBE checklist was followed. Data were collected from 251 participants (54.9% of eligible). The prevalence of frailty was 26.7%, prevalence of current pain was 68.1% and prevalence of pain in the last 24 h was 81.3%. After adjusting for age, sex, admitting service and pain severity, admitting services medical (AOR: 13.5 95% CI 5.7-32.8), mental health (AOR: 6.3, 95% CI 1. 9-20.9) and rehabilitation (AOR: 8.1, 95% CI 2.4-37.1) and moderate pain (AOR: 3.9, 95% CI 1. 6-9.8) were associated with increased frailty. The number of older patients identified in this study who were frail has implications for managing this group in a hospital setting. This indicates a need to focus on developing strategies including frailty assessment on admission, and the development of interventions to meet the care needs of these patients. The findings also highlight the need for increased pain assessment, particularly in those who are frail, for more effective pain management.Trial registration: The study was prospectively registered (ACTRN12620000904976; 14th September 2020).

292. Sodium benzoate attenuates 2,8-dihydroxyadenine nephropathy by inhibiting monocyte/macrophage TNF-α expression.

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2023 Feb 27

Oshima Y, Wakino S, Kanda T

293. Residue-specific binding of Ni(II) ions influences the structure and aggregation of amyloid beta (Aβ) peptides.

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2023 Feb 27

Berntsson E, Vosough F, Svantesson T

294. Cost-effectiveness evaluation of risk-based breast cancer screening in Urban Hebei Province.

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2023 Feb 27

Shi J, Guan Y, Liang D

To evaluate the implementations of Cancer Screening Program in Urban Hebei and to model the cost-effectiveness of a risk-based breast Cancer Screening Program. Women aged 40-74 years were invited to participate the Cancer Screening Program in Urban Hebei form 2016 to 2020 by completing questionnaires to collect information about breast cancer exposure. Clinical screening including ultrasound and mammography examination were performed. We developed a Markov model to estimate the lifetime costs and benefits, in terms of quality-adjusted life years (QALY), of a high-risk breast Cancer Screening Program. Nine screening strategies and no screening were included in the study. The age-specific incidence, transition probability data and lifetime treatment costs were derived and adopted from other researches. Average cost-effectiveness ratios (ACERs) were estimated as the ratios of the additional costs of the screening strategies to the QLYG compared to no screening. Incremental cost-effectiveness ratios (ICERs) were calculated based on the comparison of a lower cost strategies to the next more expensive and effective strategies after excluding dominated strategies and extendedly dominated strategies. ICERs were used to compare with a willingness-to-pay (WTP) threshold. Sensitivity analysis was explored the influence factors. A total of 84,029 women completed a risk assessment questionnaire, from which 20,655 high-risk breast cancer females were evaluated, with a high-risk rate of 24.58%. There were 13,392 high-risk females completed the screening program, with participation rate was 64.84%. Undergoing ultrasound, mammography and combined screening, the suspicious positive detection rates were 15.00%, 9.20% and 19.30%, and the positive detection rates were 2.11%, 2.76% and 3.83%, respectively. According to the results by Markov model, at the end of 45 cycle, the early diagnosis rates were 55.53%, 60.68% and 62.47% underwent the annual screening by ultrasound, mammography and combined, the proportion of advanced cancer were 17.20%, 15.85% and 15.36%, respectively. Different screening method and interval yield varied. In the exploration of various scenarios, annual ultrasound screening is the most cost-effective strategy with the ICER of ¥116,176.15/QALY. Sensitivity analyses demonstrated that the results are robust. Although it was not cost effective, combined ultrasound and mammography screening was an effective strategy for higher positive detection rate of breast cancer. High-risk population-based breast cancer screening by ultrasound annually was the most cost-effective strategy in Urban Hebei Province.

295. Risk perception and gratitude mediate the negative relationship between COVID-19 management satisfaction and public anxiety.

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2023 Feb 27

Mei Y, Tan L, Yang W

296. Initial results of the meteorological data from the first 325 sols of the Tianwen-1 mission.

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2023 Feb 27

Jiang C, Jiang Y, Li H

297. Photobiomodulation therapy retarded axial length growth in children with myopia: evidence from a 12-month randomized controlled trial evidence.

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2023 Feb 27

Zhou L, Tong L, Li Y

298. A survey of barriers and facilitators to ultrasound use in low- and middle-income countries.

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2023 Feb 27

Ginsburg AS, Liddy Z, Khazaneh PT

299. Discounting money and health effects from communicable and noncommunicable diseases in Thailand.

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2023 Feb 27

Yadee J, Permsuwan U, Guntawongwan K

The purpose of this study was to determine the discount rates for money and health outcomes in the Thai context, including the discount rates for communicable and non-communicable diseases. Moreover, this study aimed to explore the socio-demographic characteristics that influence discounting. The computer-based experimental design was used to obtain time preferences for money and health in a total of 1202 Chiang Mai province population, aged 25-50, individually interviewed by trained interviewers. Money-related questions were carried out in all subjects. For health-related questions, all subjects were randomly assigned in a 1:1 ratio for response to questions about Coronavirus Disease 2019 (COVID-19) (N = 602) and air pollution (N = 600). A choice-based elicitation procedure was performed in the experiment to obtain the indifference values from subjects' time preferences. The cumulative weighting functions were generated using the indifference values to indicate the degree of discounting. The discount factors were computed from the cumulative weighting functions. The discount rates were estimated using a continuous approximation based on the relationship between the discount factors and the parameters governing the discounting model. The Tobit model was applied to investigate the relationships between discounting and socio-demographic characteristics. Discounting for money was greater than discounting for health. Money and health had annual discount rates of 6.2% and 1.3%, respectively. Furthermore, in the COVID -19 situation, the annual discount rate for health was higher than that in the air pollution situation (2.4% vs. 0.7%). Generation X subjects (aged 42 years and above), children under the age of 15 in the household, and underlying diseases were positively related to discounting, while household income was negatively related to discounting. Health should be discounted at a lower rate than money. Moreover, different discount rates should be considered for different types of diseases.

300. Author Correction: Estimation of the mutation rate of Mycobacterium tuberculosis in cases with recurrent tuberculosis using whole genome sequencing.

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2023 Feb 27

Comín J, Cebollada A; Aragonese Working Group on Molecular Epidemiology of Tuberculosis (EPIMOLA); Samper S.

301. Hip arthroplasty for patients with chronic renal failure on dialysis.

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2023 Feb 27

Lee SM, Shin WC, Woo SH

302. Development of controlled nanosphere lithography technology.

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2023 Feb 27

Osipov AA, Gagaeva AE, Speshilova AB

303. Structural basis for the toxic activity of MafB2 from maf genomic island 2 (MGI-2) in N. meningitidis B16B6.

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2023 Feb 27

Park SH(#), Jeong SJ(#), Ha SC.

304. Fragmentation and correlations in a rotating Bose-Einstein condensate undergoing breakup.

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2023 Feb 27

Dutta S, Lode AUJ, Alon OE.

305. Deep learning augmented ECG analysis to identify biomarker-defined myocardial injury.

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2023 Feb 27

Chaudhari GR(#), Mayfield JJ(#), Barrios JP

306. Knowledge grounded medical dialogue generation using augmented graphs.

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2023 Feb 27

Varshney D, Zafar A, Behera NK

Smart healthcare systems that make use of abundant health data can improve access to healthcare services, reduce medical costs and provide consistently high-quality patient care. Medical dialogue systems that generate medically appropriate and human-like conversations have been developed using various pre-trained language models and a large-scale medical knowledge base based on Unified Medical Language System (UMLS). However, most of the knowledge-grounded dialogue models only use local structure in the observed triples, which suffer from knowledge graph incompleteness and hence cannot incorporate any information from dialogue history while creating entity embeddings. As a result, the performance of such models decreases significantly. To address this problem, we propose a general method to embed the triples in each graph into large-scalable models and thereby generate clinically correct responses based on the conversation history using the recently recently released MedDialog(EN) dataset. Given a set of triples, we first mask the head entities from the triples overlapping with the patient's utterance and then compute the cross-entropy loss against the triples' respective tail entities while predicting the masked entity. This process results in a representation of the medical concepts from a graph capable of learning contextual information from dialogues, which ultimately aids in leading to the gold response. We also fine-tune the proposed Masked Entity Dialogue (MED) model on smaller corpora which contain dialogues focusing only on the Covid-19 disease named as the Covid Dataset. In addition, since UMLS and other existing medical graphs lack data-specific medical information, we re-curate and perform plausible augmentation of knowledge graphs using our newly created Medical Entity Prediction (MEP) model. Empirical results on the MedDialog(EN) and Covid Dataset demonstrate that our proposed model outperforms the state-of-the-art methods in terms of both automatic and human evaluation metrics.

307. Influence of carbon nanotube suspensions on Casson fluid flow over a permeable shrinking membrane: an analytical approach.

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2023 Feb 27

Mahesh R, Mahabaleshwar US, Sofos F.

308. Parental personality and early life ecology: a prospective cohort study from preconception to postpartum.

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2023 Feb 27

Spry EA, Olsson CA, Aarsman SR

309. Access to information and oncofertility consultation for young women with breast cancer: a population-based study.

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2023 Feb 27

Martinet-Kosinski F, Lamy S, Bauvin E

310. Changes in task performance and frontal cortex activation within and over sessions during the n-back task.

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2023 Feb 27

Yeung MK, Han YMY.

311. Improvements in 2D p-type WSe(2) transistors towards ultimate CMOS scaling.

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2023 Feb 27

Patoary NH, Xie J, Zhou G

312. Immature platelet fraction predicts early marrow recovery after severe chemotherapy associated neutropenia.

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2023 Feb 27

Salvador C, Meryk A, Hetzer B

313. Causes for an extreme cold condition over Northeast Asia during April 2020.

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2023 Feb 27

Kim GU, Oh H, Kim YS

314. Differences in nutritional risk assessment between NRS2002, RFH-NPT and LDUST in cirrhotic patients.

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2023 Feb 27

Zhang P, Wang Q, Zhu M

Nutritional status is an independent predictor of outcome in cirrhosis patients. Nutritional Risk Screening 2002 (NRS2002), Royal Free Hospital-Nutritional Prioritizing Tool (RFH-NPT), and Liver Disease Undernutrition Screening Tool (LDUST) were employed to detect cirrhosis with malnutrition risk in this work. Meanwhile, their diagnostic performances were compared to find the best screening method. This work aimed to establish the sarcopenia cut-off value of the transversal psoas thickness index (TPTI), and identify the risk factors for malnutrition. Cirrhosis patients who were admitted to Heibei Gerneral hospital from April 2021 to October 2021 and underwent abdominal CT examination were enrolled. 78 patients were assessed by NRS2002, RFH-NPT, and LDUST. The Global Leadership Initiative for Malnutrition (GLIM) criteria were selected as the gold standard for the diagnosis of malnutrition. Meanwhile the cut-off value of sarcopenia was established based on the TPTI of malnourished patients. Logistic regression analysis was adopted to assess the influencing factors of malnutrition risk and malnutrition. The prevalence of malnutrition was 42.31%. The prevalence of malnutrition risk was 32.1%, 61.5%, and 62.8% with NRS2002, RFH-NPT, and LDUST, respectively. NRS2002 presented the best specificity compared with the other methods, while RFH-NPT showed the highest sensitivity. The optimal gender-specific TPTI cut-off value for diagnosing sarcopenia was determined as TPTI < 14.56 mm/m (male) and TPTI < 8.34 mm/m (female). In the multivariate analysis, ascites was associated with malnutrition risk, while sarcopenia showed a significant risk for malnutrition. NRS2002 and RFH-NPT were superior to LDUST at detecting the malnutrition in cirrhosis patients diagnosed according to GLIM criteria. The gender-specific TPTI cut-off value was TPTI < 14.56 mm/m (male) and TPTI < 8.34 mm/m (female). Malnutrition risk should be screened for patients with ascites as soon as possible. In addition, it was important to evaluate malnutrition in sarcopenia patients in time.

315. Correlates of burnout among healthcare workers during the COVID-19 pandemic in South Korea.

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2023 Feb 27

Hwang S, Kwon KT, Lee SH

Burnout is a form of negative emotional and physical response to job stress. This study aimed to investigate the prevalence of burnout among healthcare workers responding to the coronavirus disease 2019 (COVID-19) outbreak in Korea and to explore correlates of burnout among healthcare workers. A nationwide questionnaire-based survey was conducted from December 1, 2020, to January 29, 2021 on 1425 healthcare workers who worked in one of the 16 healthcare facilities designated for COVID-19 care, in public health centers, or as paramedics in Korea. Burnout was assessed using 16 Korean-adapted items based on the Oldenburg Burnout Inventory (OLBI). Data were collected using a structured questionnaire and analyzed using the R version 4.1.1 software program. OLBI results indicate clinically exhaustion in 84.5% (1204/1425) and clinically disengagement in 91.1% (1298/1425), and 77.3% (1102/1425) met the score criteria for both the exhaustion and disengagement subscales for burnout. Burnout rate was significantly increased in the group with chronic fatigue symptoms (Fatigue Severity Scale ≥ 3.22) after the outbreak of COVID-19 (OR, 3.94; 95% CI 2.80-5.56), in the female group (OR, 2.05; 95% CI 1.46-2.86), in the group with physical symptoms (Patient Health Questionnaire-15 ≥ 10) after the outbreak of COVID-19 (OR, 2.03; 95% CI 1.14-3.60), in the group with a higher Global Assessment of Recent Stress scale (OR, 1.71; 95% CI 1.46-2.01), in the group with post-traumatic stress symptoms (Primary Care Post-Traumatic Stress Disorder-5 ≥ 2) (OR, 1.47; 95% CI 1.08-2.01), and in the younger age group(OR, 1.45; 95% CI 1.22-1.72). The chronic fatigue symptoms were correlated with cumulative days of care (OR, 1.18; 95% CI 1.02-1.37). The physical symptoms were correlated with average contact hours with COVID-19 patients per day (OR, 1.34; 95% CI 1.17-1.54), and cumulative days of care (OR, 1.21; 95% CI 1.06-1.38). Most Korean healthcare workers suffered from burnout related to excessive workload during the COVID-19 pandemic. During a widespread health crisis like COVID-19, it is necessary to regularly check the burnout status in healthcare workers and reduce their excessive workload by supplementing the workforce and providing appropriate working hours sufficient rest hours.

316. Development of evaluation system for cerebral artery occlusion in emergency medical services: noninvasive measurement and utilization of pulse waves.

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2023 Feb 27

Shimada T, Matsubara K, Koyama D

317. Pet dog facial expression recognition based on convolutional neural network and improved whale optimization algorithm.

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2023 Feb 27

Mao Y, Liu Y.

318. Development of an array of molecular tools for the identification of khapra beetle (Trogoderma granarium), a destructive beetle of stored food products.

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2023 Feb 27

Wu Y, Domingue MJ, McGraw AR

319. Construction of a prognostic prediction model for renal clear cell carcinoma combining clinical traits.

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2023 Feb 27

Weng Y, Ning P.

Kidney renal clear cell carcinoma (KIRC) is one of the common malignant tumors of the urinary system. Patients with different risk levels are other in terms of disease progression patterns and disease regression. The poorer prognosis for high-risk patients compared to low-risk patients. Therefore, it is essential to accurately high-risk screen patients and gives accurate and timely treatment. Differential gene analysis, weighted correlation network analysis, Protein-protein interaction network, and univariate Cox analysis were performed sequentially on the train set. Next, the KIRC prognostic model was constructed using the least absolute shrinkage and selection operator (LASSO), and the Cancer Genome Atlas (TCGA) test set and the Gene Expression Omnibus dataset verified the model's validity. Finally, the constructed models were analyzed; including gene set enrichment analysis (GSEA) and immune analysis. The differences in pathways and immune functions between the high-risk and low-risk groups were observed to provide a reference for clinical treatment and diagnosis. A four-step key gene screen resulted in 17 key factors associated with disease prognosis, including 14 genes and 3 clinical features. The LASSO regression algorithm selected the seven most critical key factors to construct the model: age, grade, stage, GDF3, CASR, CLDN10, and COL9A2. In the training set, the accuracy of the model in predicting 1-, 2- and 3-year survival rates was 0.883, 0.819, and 0.830, respectively. The accuracy of the TCGA dataset was 0.831, 0.801, and 0.791, and the accuracy of the GSE29609 dataset was 0.812, 0.809, and 0.851 in the test set. Model scoring divided the sample into a high-risk group and a low-risk group. There were significant differences in disease progression and risk scores between the two groups. GSEA analysis revealed that the enriched pathways in the high-risk group mainly included proteasome and primary immunodeficiency. Immunological analysis showed that CD8 (+) T cells, M1 macrophages, PDCD1, and CTLA4 were upregulated in the high-risk group. In contrast, antigen-presenting cell stimulation and T-cell co-suppression were more active in the high-risk group. This study added clinical characteristics to constructing the KIRC prognostic model to improve prediction accuracy. It provides help to assess the risk of patients more accurately. The differences in pathways and immunity between high and low-risk groups were also analyzed to provide ideas for treating KIRC patients.

320. Association between quality control and outcomes of septic shock caused by intestinal perforation in China: a cross-sectional study.

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2023 Feb 27

Wang L(#), Ma X(#), He H(#)

Septic shock, largely caused by intestinal perforation, is a common critical disease in intensive care unit (ICU). For hospitals and health systems, a performance improvement program for sepsis was strong recommended in guidelines. Numerous studies have shown that improved quality control improves outcomes in patients with septic shock. Nevertheless, association between quality control and outcomes of septic shock caused by intestinal perforation are not fully revealed. Thus we designed this study to investigate effects of quality control on septic shock caused by intestinal perforation in China. This was a multicenter observational study. A total of 463 hospitals were enrolled in this survey, led by the China National Critical Care Quality Control Center (China-NCCQC) from January 1, 2018 to December 31, 2018. In this study, the indicators of quality control included the proportion of ICU patient bed occupancy to total inpatient bed occupancy, the proportion of ICU patients with APACHE II score ≥ 15, and the microbiology detection rate before antibiotic use. The outcome indicators included hospital stays, hospitalization costs, complications, and mortality. Generalized linear mixed models were used to analyse the association between quality control and septic shock caused by intestinal perforation. The proportion of ICU patient bed occupancy to total inpatient bed occupancy is positively correlated with hospital stays, incidence of complications (ARDS, AKI) and costs in septic shock caused by intestinal perforation (p < 0.05). The proportion of ICU patients with APACHE II score ≥ 15 was not associated with hospital stays and incidence of ARDS and AKI (p < 0.05). Increasing of the proportion of ICU patients with APACHE II score ≥ 15 decreased the costs of patients with septic shock caused by intestinal perforation (p < 0.05). The microbiology detection rate before antibiotic use was not associated with hospital stays, incidence of AKI and costs of patients with septic shock caused by intestinal perforation (p < 0.05). Surprisingly, the increase of microbiology detection rate before antibiotic use increased the incidence of ARDS in patients with septic shock caused by intestinal perforation (p < 0.05). The above three indicators of quality control were not associated with mortality of the patients with septic shock caused by intestinal perforation. On the one hand, the number of ICU patients admitted should be controlled to reduce the proportion of ICU patients out of total inpatient bed occupancy. On the other hand, intensive care unit admission of severe patients (patients with APACHE II score ≥ 15) should be encouraged to improve the proportion of patients with APACHE II score ≥ 15 in the ICU, so that ICU can focus more on the treatment of severe patients and promote the professionalization of severe patient management. It is not advisable to collect sputum specimens too frequently for patients without pneumonia.

321. Hybrid de novo genome assembly and comparative genomics of three different isolates of Gnomoniopsis castaneae.

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2023 Feb 27

Turco S, Mazzaglia A, Drais MI

322. Re-analysis of publicly available methylomes using signal detection yields new information.

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2023 Feb 27

Hafner A, Mackenzie S.

323. Analgesic effects of a highly selective mPGES-1 inhibitor.

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2023 Feb 27

Stewart MJ, Weaver LM, Ding K

324. SBAS-InSAR based validated landslide susceptibility mapping along the Karakoram Highway: a case study of Gilgit-Baltistan, Pakistan.

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2023 Feb 27

Kulsoom I, Hua W, Hussain S

325. Breakthrough: a first-in-class virtual simulator for dose optimization of ACE inhibitors in translational cardiovascular medicine.

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2023 Feb 26

Schneider BK, Ward J, Sotillo S

326. Machine learning-based obesity classification considering 3D body scanner measurements.

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2023 Feb 26

Jeon S, Kim M, Yoon J

327. Gestational age and trajectories of body mass index and height from birth through adolescence in the Danish National Birth Cohort.

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2023 Feb 26

Vinther JL, Ekstrøm CT, Sørensen TIA

328. High frequency conductivity decomposition by solving physically constraint underdetermined inverse problem in human brain.

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2023 Feb 25

Kwon OI, Lee MB, Jahng GH.

The developed magnetic resonance electrical properties tomography (MREPT) can visualize the internal conductivity distribution at Larmor frequency by measuring the B1 transceive phase data from magnetic resonance imaging (MRI). The recovered high-frequency conductivity (HFC) value is highly complex and heterogeneous in a macroscopic imaging voxel. Using high and low b-value diffusion weighted imaging (DWI) data, the multi-compartment spherical mean technique (MC-SMT) characterizes the water molecule movement within and between intra- and extra-neurite compartments by analyzing the microstructures and underlying architectural organization of brain tissues. The proposed method decomposes the recovered HFC into the conductivity values in the intra- and extra-neurite compartments via the recovered intra-neurite volume fraction (IVF) and the diffusion patterns using DWI data. As a form of decomposition of intra- and extra-neurite compartments, the problem to determine the intra- and extra-neurite conductivity values from the HFC is still an underdetermined inverse problem. To solve the underdetermined problem, we use the compartmentalized IVF as a criterion to decompose the electrical properties because the ion-concentration and mobility have different characteristics in the intra- and extra-neurite compartments. The proposed method determines a representative apparent intra- and extra-neurite conductivity values by changing the underdetermined equation for a voxel into an over-determined minimization problem over a local window consisting of surrounding voxels. To suppress the noise amplification and estimate a feasible conductivity, we define a diffusion pattern distance to weight the over-determined system in the local window. To quantify the proposed method, we conducted a simulation experiment. The simulation experiments show the relationships between the noise reduction and the spatial resolution depending on the designed local window sizes and diffusion pattern distance. Human brain experiments (five young healthy volunteers and a patient with brain tumor) were conducted to evaluate and validate the reliability of the proposed method. To quantitatively compare the results with previously developed methods, we analyzed the errors for reconstructed extra-neurite conductivity using existing methods and indirectly verified the feasibility of the proposed method.

329. Effects of tongue right positioner use on tongue pressure: a pilot study.

Sci Rep

2023 Feb 25

Yanagida R, Hara K, Namiki C

330. Horses discriminate human body odors between fear and joy contexts in a habituation-discrimination protocol.

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2023 Feb 25

Jardat P, Destrez A, Damon F

331. On the potential of transauricular electrical stimulation to reduce visually induced motion sickness.

Sci Rep

2023 Feb 25

Molefi E, McLoughlin I, Palaniappan R.

332. Machine learning model for predicting ciprofloxacin resistance and presence of ESBL in patients with UTI in the ED.

Sci Rep

2023 Feb 25

Lee HG, Seo Y, Kim JH

333. Short-term outcome of adrenal radiofrequency ablation of adrenal cysts: a single-center experience.

Sci Rep

2023 Feb 25

Pak SJ, Lee YM, Kim PN

334. Composition, structure and robustness of Lichen guilds.

Sci Rep

2023 Feb 25

Duran-Nebreda S, Valverde S.

335. Real-time automatic temperature regulation during in vivo MRI-guided laser-induced thermotherapy (MR-LITT).

Sci Rep

2023 Feb 25

Desclides M, Ozenne V, Bour P

336. Spatio-temporal visualization and forecasting of [Formula: see text] in the Brazilian state of Minas Gerais.

Sci Rep

2023 Feb 25

da Silva KLS, López-Gonzales JL, Turpo-Chaparro JE

337. Impact of timing to initiate adjuvant therapy on survival of elderly glioblastoma patients using the SEER-Medicare and national cancer databases.

Sci Rep

2023 Feb 25

Zhu P, Du XL, Hwang LY

The optimal time to initiate adjuvant therapy (AT) in elderly patients with glioblastoma (GBM) remains unclear. We investigated the impact of timing to start AT on overall survival (OS) using two national-scale datasets covering elderly GBM populations in the United States. A total of 3159 and 8161 eligible elderly GBM patients were derived from the Surveillance, Epidemiology and End Results (SEER)-Medicare linked dataset (2004-2013) and the National Cancer Database (NCDB) (2004-2014), respectively. The intervals in days from the diagnosis to the initiation of AT were categorized based on two scenarios: Scenario I (quartiles), ≤ 15, 16-26, 27-37, and ≥ 38 days; Scenario II (median), < 27, and ≥ 27 days. The primary outcome was OS. We performed the Kaplan-Meier and Cox proportional hazards regression methods for survival analysis. A sensitivity analysis was performed using Propensity Score Matching (PSM) method to achieve well-balanced characteristics between early-timing and delayed-timing in Scenario II. Improved OS was observed among patients who underwent resection and initiated AT with either a modest delay (27-37 days) or a longer delay (≥ 38 days) compared to those who received AT immediately (≤ 15 days) from both the SEER-Medicare dataset [adjusted hazard ratio (aHR) 0.74, 95% CI 0.64-0.84, P < 0.001; and aHR 0.81, 95% CI 0.71-0.92, P = 0.002] and the NCDB (aHR 0.83, 95% CI 0.74-0.93, P = 0.001; and aHR 0.87, 95% CI 0.77-0.98, P = 0.017). The survival advantage is observed in delayed-timing group as well in Scenario II. For elderly patients who had biopsy only, improved OS was only detected in a longer delay (Scenario I: ≥ 38 days vs. ≤ 15 days) or the delayed-timing group (Scenario II: ≥ 27 days vs. < 27 days) in the NCDB while no survival difference was seen in SEER-Medicare population. For the best timing to start AT in elderly GBM patients, superior survivals were observed among those who had craniotomy and initiated AT with a modest (27-37 days) or longer delays (≥ 38 days) following diagnosis using both the SEER-Medicare and NCDB datasets (Scenario I). Such survival advantage was confirmed when categorizing delayed-timing vs. early-timing with the cut-off at 27 day in both datasets (Scenario II). The increased likelihood of receiving delayed AT (≥ 27 days) was significantly associated with tumor resection (STR/GTR), years of diagnosis after 2006, African American and Hispanics races, treatments at academic facilities, and being referred. There is no difference in timing of AT on survival among elderly GBM patients who had biopsy in the SEER-Medicare dataset. In conclusion, initiating AT with a modest delay (27-37 days) or a longer delay (≥ 38 days) after craniotomy may be the preferred timing in the elderly GBM population.

338. Reliability and validity of OpenPose for measuring hip-knee-ankle angle in patients with knee osteoarthritis.

Sci Rep

2023 Feb 25

Saiki Y, Kabata T, Ojima T

339. Assessment of foraminal decompression following discoplasty using a combination of ex vivo testing and numerical tools.

Sci Rep

2023 Feb 25

Techens C, Bereczki F, Montanari S

340. DFT-aided machine learning-based discovery of magnetism in Fe-based bimetallic chalcogenides.

Sci Rep

2023 Feb 25

Pant D, Pokharel S, Mandal S

341. Estimation of optimal tilt angles for photovoltaic panels in Egypt with experimental verifications.

Sci Rep

2023 Feb 25

Abdelaal AK, El-Fergany A.

342. A highly elastic absorbable monofilament suture fabricated from poly(3-hydroxybutyrate-co-4-hydroxybutyrate).

Sci Rep

2023 Feb 25

Murayama A, Yoneda H, Maehara A

343. Monitoring and immunogenicity of SARS-CoV-2 vaccination of laboratory rhesus monkeys (Macaca mulatta).

Sci Rep

2023 Feb 25

Oh DQP, Grothe I, Lukaß H

344. The potential utility of the SAGIT instrument in the clinical assessment of patients with acromegaly, a large single-centre study.

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2023 Feb 25

Sawicka-Gutaj N(#), Ziółkowska P(#), Biczysko A

345. Slack-based tunable damping leads to a trade-off between robustness and efficiency in legged locomotion.

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2023 Feb 25

Mo A, Izzi F, Gönen EC

346. Theoretical investigation of the MXene precursors Mo(x)V(4-x)AlC(3) (0 ≤ x ≤ 4).

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2023 Feb 25

Moreno-Armenta MG, Guerrero-Sánchez J, Gutiérrez-Ojeda SJ

347. Replication and mediation of the association between the metabolome and clinical markers of metabolic health in an adolescent cohort study.

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2023 Feb 25

Brachem C, Weinhold L, Alexy U

348. Evidence for avoidance tendencies linked to anxiety about specific types of thinking.

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2023 Feb 25

Daker RJ, Slipenkyj MS, Green AE

349. Prognostic impact of PD-L1 and TIGIT expression in non-small cell lung cancer following concurrent chemo-radiotherapy.

Sci Rep

2023 Feb 25

Mori M, Kanayama M, Kuwata T

350. A fast privacy-preserving patient record linkage of time series data.

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2023 Feb 25

Soliman A, Rajasekaran S, Toman P

351. Influence of aldo-keto reductase 1C3 polymorphisms in early-onset female psoriasis patients.

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2023 Feb 25

Nojiri Y, Nakamura M, Magara T

352. Variational quantum approximate support vector machine with inference transfer.

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2023 Feb 25

Park S, Park DK, Rhee JK.

353. Differential expression of interferon-induced protein with tetratricopeptide repeats 3 (IFIT3) in Alzheimer's disease and HIV-1 associated neurocognitive disorders.

Sci Rep

2023 Feb 25

Garces A, Martinez B, De La Garza R

354. Removal of toxic lead from aqueous solution using a low-cost adsorbent.

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2023 Feb 25

Dehghani MH, Afsari Sardari S, Afsharnia M

355. Imaging biomarkers and clinical factors associated with the rate of progressive inner and outer retinal thinning in patients with diabetic macular edema.

Sci Rep

2023 Feb 24

Borrelli E, Barresi C, Feo A

356. Accurate holographic light potentials using pixel crosstalk modelling.

Sci Rep

2023 Feb 24

Schroff P, La Rooij A, Haller E

357. Named entity recognition for Chinese based on global pointer and adversarial training.

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2023 Feb 24

Li H, Cheng M, Yang Z

358. Environmental changes associated with drying climate are expected to affect functional groups of pro- and microeukaryotes differently in temporary saline waters.

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2023 Feb 24

Márton Z, Szabó B, Vad CF

359. Fast simultaneous estimation of nD transport coefficients and source function in perturbation experiments.

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2023 Feb 24

van Kampen R, de Vries J, Weiland S

360. Experimental venous thrombus resolution is driven by IL-6 mediated monocyte actions.

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2023 Feb 24

Obi AT, Sharma SB, Elfline MA

361. Development and validation of a cynomolgus macaque grimace scale for acute pain assessment.

Sci Rep

2023 Feb 24

Paterson EA, O'Malley CI, Moody C

362. The microstructure, mechanical and electrochemical properties of 3D printed alloys with reusing powders.

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2023 Feb 24

Bajt Leban M, Hren M, Kosec T.

363. Risk factors for wound healing complications after revascularization for MMD with complete Y-shaped incision.

Sci Rep

2023 Feb 24

Wang C, Li H, Dong Y

364. A comprehensive overview of SMN and NAIP copy numbers in Iranian SMA patients.

Sci Rep

2023 Feb 24

Savad S, Ashrafi MR, Samadaian N

365. Enlightening the bimetallic effect of Au@Pd nanoparticles on Ni oxide nanostructures with enhanced catalytic activity.

Sci Rep

2023 Feb 24

Bruno L, Scuderi M, Priolo F

366. Automated in-depth cerebral arterial labelling using cerebrovascular vasculature reframing and deep neural networks.

Sci Rep

2023 Feb 24

Hong SW, Song HN, Choi JU

Identifying the cerebral arterial branches is essential for undertaking a computational approach to cerebrovascular imaging. However, the complexity and inter-individual differences involved in this process have not been thoroughly studied. We used machine learning to examine the anatomical profile of the cerebral arterial tree. The method is less sensitive to inter-subject and cohort-wise anatomical variations and exhibits robust performance with an unprecedented in-depth vessel range. We applied machine learning algorithms to disease-free healthy control subjects (n = 42), patients with stroke with intracranial atherosclerosis (ICAS) (n = 46), and patients with stroke mixed with the existing controls (n = 69). We trained and tested 70% and 30% of each study cohort, respectively, incorporating spatial coordinates and geometric vessel feature vectors. Cerebral arterial images were analyzed based on the 'segmentation-stacking' method using magnetic resonance angiography. We precisely classified the cerebral arteries across the exhaustive scope of vessel components using advanced geometric characterization, redefinition of vessel unit conception, and post-processing algorithms. We verified that the neural network ensemble, with multiple joint models as the combined predictor, classified all vessel component types independent of inter-subject variations in cerebral arterial anatomy. The validity of the categorization performance of the model was tested, considering the control, ICAS, and control-blended stroke cohorts, using the area under the receiver operating characteristic (ROC) curve and precision-recall curve. The classification accuracy rarely fell outside each image's 90-99% scope, independent of cohort-dependent cerebrovascular structural variations. The classification ensemble was calibrated with high overall area rates under the ROC curve of 0.99-1.00 [0.97-1.00] in the test set across various study cohorts. Identifying an all-inclusive range of vessel components across controls, ICAS, and stroke patients, the accuracy rates of the prediction were: internal carotid arteries, 91-100%; middle cerebral arteries, 82-98%; anterior cerebral arteries, 88-100%; posterior cerebral arteries, 87-100%; and collections of superior, anterior inferior, and posterior inferior cerebellar arteries, 90-99% in the chunk-level classification. Using a voting algorithm on the queued classified vessel factors and anatomically post-processing the automatically classified results intensified quantitative prediction performance. We employed stochastic clustering and deep neural network ensembles. Ma-chine intelligence-assisted prediction of vessel structure allowed us to personalize quantitative predictions of various types of cerebral arterial structures, contributing to precise and efficient decisions regarding the cerebrovascular disease.

367. Design, development, in-vitro and in-vivo evaluation of polylactic acid-based multifunctional nanofibrous patches for efficient healing of diabetic wounds.

Sci Rep

2023 Feb 24

Ali IH(#), Khalil IA(#), El-Sherbiny IM.

368. Curvilinear regression analysis of benzenoid hydrocarbons and computation of some reduced reverse degree based topological indices for hyaluronic acid-paclitaxel conjugates.

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2023 Feb 24

Ravi V, Desikan K.

369. Classification of deep-sea cold seep bacteria by transformer combined with Raman spectroscopy.

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2023 Feb 24

Liu B(#), Liu K(#), Qi X

370. A new patient-specific overformed anatomical implant design method to reconstruct dysplastic femur trochlea.

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2023 Feb 24

Öztürk Y, Ayazoğlu M, Öztürk Ç

371. Electromagnetic metamaterials to approach superconductive-like electrical conductivity.

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2023 Feb 24

Danisi A, Zannini C.

372. Predicting tracheostomy in multiple injured patients with severe thoracic injury (AIS ≥ 3) with the new T(3)P-Score: a multivariable regression prediction analysis.

Sci Rep

2023 Feb 24

Bläsius FM, Wutzler S, Störmann P

Multiple trauma patients with severe chest trauma are at increased risk for tracheostomy. While the risk factors associated with the need for tracheostomy are well established in the general critical care population, they have not yet been validated in a cohort of patients suffering severe thoracic trauma. This retrospective cohort study analysed data on patients aged 18 years or older who were admitted to one of the six participating academic level I trauma centres with multiple injuries, including severe thoracic trauma (AISThorax ≥ 3) between 2010 and 2014. A multivariable binary regression was used to identify predictor variables for tracheostomy and to develop the Tracheostomy in Thoracic Trauma Prediction Score (T3P-Score). The study included 1019 adult thoracic trauma patients, of whom 165 underwent tracheostomy during their intensive care unit (ICU) stay. Prehospital endotracheal intubation (adjusted OR [AOR]: 2.494, 95% CI [1.412; 4.405]), diagnosis of pneumonia during the ICU stay (AOR: 4.374, 95% CI [2.503; 7.642]), duration of mechanical ventilation (AOR: 1.008/hours of intubation, 95% CI [1.006; 1.009]), and an AISHead ≥ 3 (AOR 1.840, 95% CI [1.039; 3.261]) were independent risk factors for tracheostomy. Patients with sepsis had a lower risk of tracheostomy than patients without sepsis (AOR 0.486, 95% CI [0.253; 0.935]). The T3P-Score had high predictive validity for tracheostomy (ROCAUC = 0.938, 95% CI [0.920, 0.956]; Nagelkerke's R2 was 0.601). The T3P-Score's specificity was 0.68, and the sensitivity was 0.96. The severity of thoracic trauma did not predict the need for tracheostomy. Follow-up studies should validate the T3P-Score in external data sets and study the reasons for the reluctant use of tracheostomy in patients with severe thoracic trauma and subsequent sepsis.Trial registration: The study was applied for and registered a priori with the respective ethics committees.

373. Bovine tumor necrosis factor-alpha Increases IL-6, IL-8, and PGE2 in bovine fibroblast-like synoviocytes by metabolic reprogramming.

Sci Rep

2023 Feb 24

Manosalva C(#), Alarcon P(#), Quiroga J

Lameness is a common condition in dairy cattle caused by infectious or noninfectious agents. Joint lesions are the second most common cause of lameness and can be diagnosed in association with the presentation of digit injuries. Fibroblast-like synoviocyte (FLS) are predominant cells of synovia and play a key role in the pathophysiology of joint diseases, thus increasing the expression of proinflammatory mediators. Tumor necrosis factor-alpha (TNF-α) is a potent proinflammatory cytokine involved in cyclooxygenase 2 (COX-2) and proinflammatory cytokine expression in FLS. Previously, TNF-α was demonstrated to increase hypoxia-inducible Factor 1 (HIF-1), a transcription factor that rewires cellular metabolism and increases the expression of interleukin (IL)-6 in bovine FLS (bFLS). Despite this, the proinflammatory effects of TNF-α in bFLS on metabolic reprogramming have been poorly studied. We hypothesized that TNF-α increases glycolysis and in this way controls the expression of IL-6, IL-8, and COX-2 in bFLS. Results first, gas chromatography/mass spectrometry (GC/MS)-based untargeted metabolomics revealed that bTNF-α altered the metabolism of bFLS, increasing glucose, isoleucine, leucine, methionine, valine, tyrosine, and lysine and decreasing malate, fumarate, α-ketoglutarate, stearate, palmitate, laurate, aspartate, and alanine. In addition, metabolic flux analysis using D-glucose-13C6 demonstrated an increase of pyruvate and a reduction in malate and citrate levels, suggesting a decreased flux toward the tricarboxylic acid cycle after bTNF-α stimulation. However, bTNF-α increased lactate dehydrogenase subunit A (LDHA), IL-6, IL-8, IL-1β and COX-2 expression, which was dependent on glycolysis and the PI3K/Akt pathway. The use of FX11 and dichloroacetate (DCA), an inhibitor of LDHA and pyruvate dehydrogenase kinase (PDK) respectively, partially reduced the expression of IL-6. Our results suggest that bTNF-α induces metabolic reprogramming that favors glycolysis in bFLS and increases IL-6, IL-8, IL-1β and COX-2/PGE2.

374. Synthesis of a magnetic polystyrene-supported Cu(II)-containing heterocyclic complex as a magnetically separable and reusable catalyst for the preparation of N-sulfonyl-N-aryl tetrazoles.

Sci Rep

2023 Feb 24

Nasrollahzadeh M, Motahharifar N, Pakzad K

375. Explainable AI for unveiling deep learning pollen classification model based on fusion of scattered light patterns and fluorescence spectroscopy.

Sci Rep

2023 Feb 24

Brdar S, Panić M, Matavulj P

376. Synthesis, experimental and computational studies on the anti-corrosion performance of substituted Schiff bases of 2-methoxybenzaldehyde for mild steel in HCl medium.

Sci Rep

2023 Feb 24

Ibeji CU, Akintayo DC, Oluwasola HO

377. Additional flight delays and magnetospheric-ionospheric disturbances during solar storms.

Sci Rep

2023 Feb 24

Wang Y, Xu XH, Wei FS

378. Variability by region and method in human brain sodium concentrations estimated by (23)Na magnetic resonance imaging: a meta-analysis.

Sci Rep

2023 Feb 24

Ridley B, Morsillo F, Zaaraoui W

379. Optimization of quasi-hemispherical CdZnTe detectors by means of first principles simulation.

Sci Rep

2023 Feb 24

Vicini V, Zanettini S, Sarzi Amadè N

380. Impact of activation energy and variable properties on peristaltic flow through porous wall channel.

Sci Rep

2023 Feb 24

Rafiq M, Shaheen A, Trabelsi Y

381. Two-year outcomes of treat-and-extend regimen with intravitreal brolucizumab for treatment-naïve neovascular age-related macular degeneration with type 1 macular neovascularization.

Sci Rep

2023 Feb 24

Matsumoto H, Hoshino J, Nakamura K

382. Comparison of clinicopathological characteristics and survival between symptomatic and asymptomatic anaplastic thyroid carcinoma.

Sci Rep

2023 Feb 24

Cho S, Kim H, Oh YL

Although anaplastic thyroid carcinoma (ATC) is a fatal form of thyroid cancer with an overall survival of only a few months, there are some factors associated with longer survival. However, it remains unknown whether asymptomatic ATC differs from symptomatic ATC in terms of characteristics and overall prognosis. Therefore, we aimed to examine the clinicopathological characteristics and prognosis of asymptomatic ATC compared with those of symptomatic ATC. We retrospectively reviewed the medical records of 113 patients with ATC who were registered at our institution between November 1994 and July 2020. A total of 86 patients (59 women and 27 men; mean age, 66.9 ± 11.1 years) were enrolled for analysis. The clinicopathological characteristics of the ATC cohort were evaluated, and prognostic factors associated with disease-specific mortality were assessed. Of the 86 patients with ATC, 78 were symptomatic and eight were asymptomatic. Compared with the symptomatic group, the asymptomatic group had a younger age at diagnosis (59.3 ± 10.3 vs. 67.7 ± 11.0 years, p = 0.045), smaller tumor size (2.8 ± 1.2 vs. 5.8 ± 2.0 cm, p < 0.001), and longer survival period (37.5 ± 46.4, 9.5 ± 16.8 months, p < 0.001). However, the ATC component (%) of the tumor, sex, ultrasonographic risk category, and distant metastasis at diagnosis did not differ significantly between the two groups. In the multivariate Cox regression analysis, asymptomatic ATC (HR: 0.33, 95% CI 0.11-0.99, p = 0.045) and absence of distant metastasis (hazard ratio (HR): 0.56, 95% Confidence interval (CI) 0.35-0.88, p = 0.012) were associated with longer survival. Patients with asymptomatic ATC have a smaller tumor size, a longer survival period, and a younger age than those with symptomatic ATC. Being asymptomatic and having no distant metastasis were associated with longer survival in patients with ATC in a clinical setting.

383. Two wild carnivores selectively forage for prey but not amino acids.

Sci Rep

2023 Feb 24

Dwyer GK, Stoffels RJ, Silvester E

384. The clinical characteristics of anemia in native adults living at different altitudes of the Tibetan Plateau.

Sci Rep

2023 Feb 24

Fang J(#), Li R(#), Ye D(#)

385. Biogenic copper oxide nanoparticles from Bacillus coagulans induced reactive oxygen species generation and apoptotic and anti-metastatic activities in breast cancer cells.

Sci Rep

2023 Feb 24

Dolati M, Tafvizi F, Salehipour M

The present study examined the anticancer capabilities of Bacillus coagulans supernatant-produced copper oxide nanoparticles (BC-CuONPs) on MCF-7 and SKBR3 cancer cells. The X-ray diffraction, ultraviolet-visible spectroscopy, Fourier-transform infrared spectroscopy, X-ray photoelectron spectroscopy, transmission electron microscopy, field-emission scanning electron microscopy, energy-dispersive X-ray, dynamic light scattering, and zeta potential techniques were used to characterize BC-CuONPs. This study also investigated the cellular and molecular processes of NPs' anti-proliferative and apoptotic properties on human breast cancer cells and compared them to the commercial pharmaceutical tamoxifen. The size of the spherical NP was from 5 to 47 nm with negative zeta potential. The MTT results showed the great cytotoxic effect of BC-CuONPs against breast cancer cells. The BC-CuONPs inhibited the growth of breast cancer cells in a time- and dose-dependent manner. The up-regulation of BCL2-associated X (BAX), cyclin dependent kinase inhibitor 1A (P21), Caspase 3 (CASP3), and Caspase 9 (CASP9), the down-regulation of BCL2 apoptosis regulator (BCL2), Annexin V-FITC/propidium iodide, and reactive oxygen species (ROS) generation results suggested that BC-CuONPs had a significant apoptotic impact when compared to the control. Scratch tests and vascular endothelial growth factor receptor gene (VEGF) down-regulation demonstrated that BC-CuONPs had anti-metastatic activity. The cell cycle analysis and down-regulation of Cyclin D1 (CCND1) and cyclin dependent kinase 4 (CDK4) revealed that cancer cells were arrested in the sub-G1 phase. Finally, the results showed that the secondary metabolites in the supernatant of Bacillus coagulans could form CuONPs, and biogenic BC-CuONPs showed anti-metastasis and anticancer properties on breast cancer cells while having less adverse effects on normal cells. Therefore, the synthesized CuONPs using B. coagulans supernatant can be shown as a potential candidate for a new therapeutic strategy in cancer management.

386. Prevalence of perioperative asymptomatic venous thromboses of the lower extremity in 30 consecutive patients undergoing transsphenoidal surgery for Cushing's disease.

Sci Rep

2023 Feb 24

Huckhagel T, Atlihan G, Langer F

Cushing´s disease is a rare endocrinological disorder which is caused by an adrenocorticotropic hormone secreting pituitary adenoma. The condition is associated with an increased risk for venous thromboembolism. While there exist reports on symptomatic venous thromboses complicating Cushing's disease, the prevalence of incidental leg vein thromboses accompanying pituitary surgery for Cushing's disease is yet unknown. 30 consecutive patients (9 male; age 25-77 years) with histologically confirmed Cushing's disease underwent transsphenoidal adenomectomy between October 2018 and September 2019. All patients received perioperative pharmacological thromboprophylaxis. Whole leg compression ultrasound was performed within one week after surgery (median 2 days) to exclude leg vein thromboses (primary endpoint). Preoperative laboratory values including plasma cortisol and various coagulation parameters were evaluated as secondary outcome measures. A comparison was made between patients with and without thrombotic events (p value ≤ 0.05). A total of 2 out of 30 patients (6.7%; CI 0.8-24.1%) presented with asymptomatic perioperative deep vein thromboses of the lower legs. Thrombosis patients differed not significantly from their counterparts with respect to age, sex, and comorbidities, but preoperative morning plasma cortisol was significantly higher in patients with venous thromboses (421.0 ± 49.5 μg/l vs. 188.1 ± 78.2 μg/l; p = 0.01). Moreover, von Willebrand factor activity was markedly increased in one case (409.0%) compared to the mean value obtained from 28 patients without phlebothromboses (146.9 ± 60.7%; p < 0.01). Perioperative asymptomatic leg vein thrombosis can be found with the aid of compression ultrasound in a considerable proportion of patients undergoing transsphenoidal adenomectomy for Cushing's disease despite the administration of pharmacological thromboprophylaxis.

387. Implementation of helicase-dependent amplification with SYBR Green I for prompt naked-eye detection of bacterial contaminants in platelet products.

Sci Rep

2023 Feb 24

Yamket W, Sathianpitayakul P, Santanirand P

388. In-situ formation of Ag nanoparticles in the MAO coating during the processing of cp-Ti.

Sci Rep

2023 Feb 24

Maj Ł, Fogarassy Z, Wojtas D

389. Heterogenous effects of the Great East Japan earthquake on prosociality of people depending on their age.

Sci Rep

2023 Feb 24

Sawada Y, Ashida T, Iwasaki K.

390. Formulas calculating the reactance of tubular busbars and their derivation in primary electrical connection schemes.

Sci Rep

2023 Feb 24

Ge Q, Li Z, Liu S

391. Removal of Cu(2+), Fe(2+) and SO(4)(2-) ions from industrial wastewater by ion exchange resins contained in a rotating perforated cylindrical basket of different heights.

Sci Rep

2023 Feb 24

Zakaria KK, Farag HA, El-Gayar DA.

392. Study on the synthesis mechanism of sodalite, gismondine, and zeolite-P1 zeolite materials from ladle furnace slag and fly ash.

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2023 Feb 24

Ma W, Yi Y, Fang M

393. Improving performance of mesoporous MOF AlTp impregnated with ionic liquids for CO(2) adsorption.

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2023 Feb 24

Noorani N, Mehrdad A.

394. Variable fluid properties analysis for thermally laminated 3-dimensional magnetohydrodynamic non-Newtonian nanofluid over a stretching sheet.

Sci Rep

2023 Feb 24

Akbar NS, Al-Zubaidi A, Saleem S

395. Study on mechanical properties and energy change of rock materials in whole splitting process based on peridynamics.

Sci Rep

2023 Feb 24

Li H, Liu J, Wang L

396. Folate receptor targeted nanoparticles containing niraparib and doxorubicin as a potential candidate for the treatment of high grade serous ovarian cancer.

Sci Rep

2023 Feb 24

Wang L, Evans JC, Ahmed L

397. Genetic diversity of virus auxiliary metabolism genes associated with phosphorus metabolism in Napahai plateau wetland.

Sci Rep

2023 Feb 24

Yu H(#), Xiong L(#), Li Y

398. Novel approach to studying effects of inhalational exposure on lung function in civilians exposed to the World Trade Center disaster.

Sci Rep

2023 Feb 24

Wang Y, Berger KI, Zhang Y

399. Diagnosing malignant distal bile duct obstruction using artificial intelligence based on clinical biomarkers.

Sci Rep

2023 Feb 24

Sugimoto Y, Kurita Y(#), Kuwahara T(#)

400. A facile novel synthesis of AgCuO(2) delafossite nanoparticles and evaluation of their antimicrobial activity.

Sci Rep

2023 Feb 23

Ateia EE, Arman MM, Mohamed AT.

Bi-functional nano-oxides are of growing interest to address environmental issues. In the present study, the structural and magnetic data are presented together with the antimicrobial activities (AMA). For the first time, silver delafossite oxide (AgCuO2) is successfully fabricated using a simple, low-cost technique to target antibiotic photodegradation and inactivation of model waterborne pathogens. It is prepared with an equimolar initial Ag+:Cu+ concentration ratio. The structure, morphology, and magnetic properties are studied by different characterization techniques. The size and shape of AgCuO2 NPs, in addition to their structural polytypes of 2H (hexagonal) or 3R (rhombohedral), are dependent on the preparation conditions. The existence of Cu, Ag, and O in the synthesized delafossite AgCuO2 NPs with no evidence of any impurity is ratified by the XPS spectrum. AFM measurements are taken to characterize the surface morphologies of AgCuO2. The distributed spiks are evaluated by roughness kurtosis (Rku). The roughness kurtosis has a value of 2.65 (< 3), indicating that the prepared sample is classified as bumpy. The prepared sample has 13.0, 10.0, 14.0, and 14.0 mm Inhibition Zone Diameter (IZD) antimicrobial activity against gram-positive Bacillus subtilis (B. subtilis), Bacillus cereus (B. cereus), Enterococcus faecalis (E. faecalis), and Staphylococcus aureus (S. aureus), respectively. The IZD for gram-negative Escherichia coli (E. coli), Neisseria Gonorrhoeae (N. Gonorrhoeae), Pseudomonas aeruginosa (P. aeruginosa), and Salmonella typhimrium (S. typhimrium) were found to be 12.0, 13.0, 14.0, and 13.0 mm, respectively. Therefore, the AgCuO2 NPs reveal excellent antimicrobial efficiency, and they can be effortlessly separated using a tiny magnet or a simple magnetic separator. The adequate cytotoxicity and magnetic characteristics of the antimicrobial sample suggest a promising future for it in biomedical applications.

401. Motor-effector dependent modulation of sensory-motor processes identified by the multivariate pattern analysis of EEG activity.

Sci Rep

2023 Feb 23

Choi K(#), Woo S(#), Lee J.

402. Domes and semi-capsules as model systems for infrared microspectroscopy of biological cells.

Sci Rep

2023 Feb 23

Solheim JH(#), Brandsrud MA(#), Kong B

403. A novel computational approach to pain perception modelling within a Bayesian framework using quantitative sensory testing.

Sci Rep

2023 Feb 23

Drusko A(#), Baumeister D(#), McPhee Christensen M

404. Modeling present and future distribution of plankton populations in a coastal upwelling zone: the copepod Calanus chilensis as a study case.

Sci Rep

2023 Feb 23

Rivera R, Escribano R, González CE

405. Identifying important nodes in complex networks based on extended degree and E-shell hierarchy decomposition.

Sci Rep

2023 Feb 23

Liu J, Zheng J.

406. Hippocampal volumetry to determine the resection side in patients with intractable non-lesional bilateral temporal lobe epilepsy.

Sci Rep

2023 Feb 23

Seyama G, Iida K, Kagawa K

407. Investigating responses to object-labels in the domestic dog (Canis familiaris).

Sci Rep

2023 Feb 23

Kőszegi H, Fugazza C, Magyari L

408. Implicit feedback policies for COVID-19: why "zero-COVID" policies remain elusive.

Sci Rep

2023 Feb 23

Jadbabaie A, Sarker A, Shah D.

409. The diachronic trend of female and male stature in Milan over 2000 years.

Sci Rep

2023 Feb 23

Biehler-Gomez L, Del Bo B, Petrosino D

410. Use of access port covers in transport incubators to improve thermoregulation during neonatal transport.

Sci Rep

2023 Feb 23

Fukuyama T, Arimitsu T.

411. Design and fabrication of superhydrophobic cellulose nanocrystal films by combination of self-assembly and organocatalysis.

Sci Rep

2023 Feb 23

Alimohammadzadeh R, Sanhueza I, Córdova A.

412. Observation of near-inertial waves in the wake of four typhoons in the northern South China Sea.

Sci Rep

2023 Feb 23

Gong Q, Wang Q, Chen L

413. Bile metabolites as diagnostic biomarkers for perihilar cholangiocarcinoma.

Sci Rep

2023 Feb 23

Zhang D(#), Zhao G(#), Sun W

414. Feasibility of an inertial measurement unit sensor-based guiding system for benign paroxysmal positional vertigo treatment: A pilot study.

Sci Rep

2023 Feb 23

Pastor CAC(#), Kwon C(#), Joo JS

Performing an accurate canalith repositioning procedure (CRP) is important for treating benign paroxysmal positional vertigo, because inadequate rotational head angles can result in ineffective otolith mobilization and consequent treatment failure. Specialists-guided Epley maneuver reportedly had mean errors of 13.7°-24.4° while they were significantly larger (40.0°-51.5°) when self-administered. Similar results were obtained for the Barbeque maneuver: mean errors were 9.2°-13.0° by the specialists while they were significantly larger (22.9°-28.6°) when self-administered. Our study aimed to validate the feasibility of an inertial measurement unit sensor-based CRP (IMU-CRP) by analyzing the differences in accuracy in the rotational angles, comparing them with education-based conventional CRP (EDU-CRP). A pilot validation was also performed by analyzing the treatment success rate of IMU-CRP in patients with BPPV. This single-institution prospective, comparative effectiveness study examined 19 participants without active vertigo or prior knowledge of benign paroxysmal positional vertigo and CRP. Participants conducted the Epley and Barbeque roll maneuvers without and with auditory guidance (EDU-CRP vs. IMU-CRP, respectively) twice, and head rotation accuracies were compared. Differences in target angles based on the American Academy of Otolaryngology-Head and Neck Surgery guidelines were considered errors. For BPPV participants, treatment success was assessed based on the presence or absence of nystagmus, vertigo, and dizziness. For all the Epley and Barbeque roll maneuvers steps, the absolute errors were smaller for IMU- than for EDU-CRPs, with significant differences in steps 2-4 and 3-6 of the Epley and Barbeque roll maneuvers, respectively. A learning effect was found in steps 4 and 5 of the Barbeque roll maneuver but not in the Epley maneuver. The treatment success rates after 1 h were 71.4% and 100% for the Epley and Barbeque roll maneuvers, respectively. Real-time feedback on head rotation angles induced more appropriate movements in the Epley and Barbeque roll maneuvers. A guiding device based on head monitoring providing real-time auditory feedback may increase the self-administered CRP success rates in treating benign paroxysmal positional vertigo.

415. Estimation of rocks' failure parameters from drilling data by using artificial neural network.

Sci Rep

2023 Feb 23

Siddig O, Ibrahim AF, Elkatatny S.

416. A CRISPR-Cas9-mediated F0 screen to identify pro-regenerative genes in the zebrafish retinal pigment epithelium.

Sci Rep

2023 Feb 23

Lu F, Leach LL, Gross JM.

417. NOTCH2NLC GGC repeats are not expanded in Italian amyotrophic lateral sclerosis patients.

Sci Rep

2023 Feb 23

Manini A, Gagliardi D, Meneri M

418. Measuring visual information gathering in individuals with ultra low vision using virtual reality.

Sci Rep

2023 Feb 23

Kartha A, Sadeghi R, Bradley C

419. Facile preparation of flame-retardant cellulose composite with biodegradable and water resistant properties for electronic device applications.

Sci Rep

2023 Feb 23

Chandrasekaran S, Cruz-Izquierdo A, Castaing R

420. Scaling-up strategies for controllable biosynthetic ZnO NPs using cell free-extract of endophytic Streptomyces albus: characterization, statistical optimization, and biomedical activities evaluation.

Sci Rep

2023 Feb 23

El-Moslamy SH, Elnouby MS, Rezk AH

421. Development of a chub mackerel with less-aggressive fry stage by genome editing of arginine vasotocin receptor V1a2.

Sci Rep

2023 Feb 23

Ohga H, Shibata K, Sakanoue R

422. Numerical solution of neutral delay differential equations using orthogonal neural network.

Sci Rep

2023 Feb 23

Vinodbhai CD, Dubey S.

423. Quantification of the methodological error in kinematic evaluation of the DRUJ using dynamic CT.

Sci Rep

2023 Feb 23

Oonk JGM, Dobbe JGG, Strackee SD

424. Targeted delivery of paclitaxel drug using polymer-coated magnetic nanoparticles for fibrosarcoma therapy: in vitro and in vivo studies.

Sci Rep

2023 Feb 23

Al-Obaidy R, Haider AJ, Al-Musawi S

Fibrosarcoma is a rare type of cancer that affects cells known as fibroblasts that are malignant, locally recurring, and spreading tumor in fibrous tissue. In this work, an iron plate immersed in an aqueous solution of double added deionized water, supplemented with potassium permanganate solution (KMnO4) was carried out by the pulsed laser ablation in liquid method (PLAIL). Superparamagnetic iron oxide nanoparticles (SPIONs) were synthesized using different laser wavelengths (1064, 532, and 266 nm) at a fluence of 28 J/cm2 with 100 shots of the iron plate to control the concentration, shape and size of the prepared high-stability SPIONs. The drug nanocarrier was synthesized by coating SPION with paclitaxel (PTX)-loaded chitosan (Cs) and polyethylene glycol (PEG). This nanosystem was functionalized by receptors that target folate (FA). The physiochemical characteristics of SPION@Cs-PTX-PEG-FA nanoparticles were evaluated and confirmed by Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), transmission electron microscopy (TEM), X-Ray diffraction (XRD), atomic force microscopy (AFM), and dynamic light scattering (DLS) methods. Cell internalization, cytotoxicity assay (MTT), apoptosis induction, and gene expression of SPION@Cs-PTX-PEG-FA were estimated in fibrosarcoma cell lines, respectively. In vivo studies used BALB/c tumor-bearing mice. The results showed that SPION@Cs-PTX-PEG-FA exhibited suitable physical stability, spherical shape, desirable size, and charge. SPION@Cs-PTX-PEG-FA inhibited proliferation and induced apoptosis of cancer cells (P < 0.01). The results of the in vivo study showed that SPION@Cs-PTX-PEG-FA significantly decreased tumor size compared to free PTX and control samples (P < 0.05), leading to longer survival, significantly increased splenocyte proliferation and IFN-γ level, and significantly decreased the level of IL-4. All of these findings indicated the potential of SPION@Cs-PTX-PEG-FA as an antitumor therapeutic agent.

425. Numerical simulation on energy transfer enhancement of a Williamson ferrofluid subjected to thermal radiation and a magnetic field using hybrid ultrafine particles.

Sci Rep

2023 Feb 23

Swalmeh MZ, Alwawi FA, Kausar MS

426. Assessing brain state and anesthesia level with two-photon calcium signals.

Sci Rep

2023 Feb 23

Tort-Colet N, Resta F, Montagni E

427. Uncertainty in vulnerability of networks under attack.

Sci Rep

2023 Feb 23

Ermagun A, Tajik N, Mahmassani H.

428. Influence of surface carbon on the performance of cesiated p-GaN photocathodes with high quantum efficiency.

Sci Rep

2023 Feb 23

Schaber J, Xiang R, Teichert J

429. The effect of a brief, unplanned treatment delay on neovascular age-related macular degeneration patients: a retrospective cohort study.

Sci Rep

2023 Feb 23

Zehden JA, Ghosh A, Soundararajan S

Non-compliance to intravitreal anti-vascular endothelial growth factor (anti-VEGF) therapy can result in increased disease activity in neovascular age-related macular degeneration (nAMD). Our study aims to determine effects of unplanned delay in anti-VEGF injection treatment for nAMD. This retrospective observational study included patients with delays in receiving intravitreal injections for nAMD treatment from March to May 2020 by at least 21 days. Baseline demographic and clinical characteristics, visual acuity (VA), central macular thickness (CMT) measured on optical coherence tomography (OCT), and duration of delayed treatment were analyzed for 3 time points, the pre-delay visit (v1) and post-delay visits (v2 and v3). Data were compared to age-matched controls treated for nAMD in 2019 without delay. Demographic characteristics were compared using two-sample t-tests for continuous variables and Pearson's chi-square tests for categorical variables. For the two primary outcomes of interest, VA and CMT, means and standard deviations were reported for each combination of group and time. Each outcome was modeled using a linear mixed model with the group, time and group-time interaction as fixed effects. A total of 69 patients (99 eyes) in the treatment delay group and 44 patients (69 eyes) in the control group were identified. Statistically significant differences between control and delayed groups were detected for VA (difference in mean logMAR = 0.16; 95% CI 0.06, 0.27; p = 0.002) and CMT (difference in mean CMT = 29; 95% CI 12, 47; p = 0.001) at v2. No differences were detected for v1 and v3 time points for both outcomes. An unplanned delay in intravitreal injection treatment for nAMD resulted in an increase in CMT and worsening of VA compared to controls observed at v2. At v3, CMT and VA recovered to near v1 levels. This study demonstrates that a one-time, brief interruption in treatment for nAMD results in reversible, temporary worsening.

430. Brown bear skin-borne secretions display evidence of individuality and age-sex variation.

Sci Rep

2023 Feb 23

Clapham M(#), Wilson AE(#), Williams CL

431. On the identification of internal solitary waves from moored observations in the northern South China Sea.

Sci Rep

2023 Feb 23

Gong Q, Chen L, Diao Y

432. Alleviation of arthritis through prevention of neutrophil extracellular traps by an orally available inhibitor of protein arginine deiminase 4.

Sci Rep

2023 Feb 23

Gajendran C, Fukui S, Sadhu NM

433. [(18)F]Tosyl fluoride as a versatile [(18)F]fluoride source for the preparation of (18)F-labeled radiopharmaceuticals.

Sci Rep

2023 Feb 23

Zhou D, Chu W, Xu J

434. Integrative taxonomy and species distribution models of the genus Diamesus Hope, 1840 (Coleoptera: Staphylinidae: Silphinae).

Sci Rep

2023 Feb 23

Růžička J, Jakubec P, Mahlerová K

435. Evaluation of polyhydroxyalkanoate (PHA) synthesis by Pichia sp. TSLS24 yeast isolated in Vietnam.

Sci Rep

2023 Feb 23

Thu NTT, Hoang LH, Cuong PK

436. Zebrafish Larvae Position Tracker (Z-LaP Tracker): a high-throughput deep-learning behavioral approach for the identification of calcineurin pathway-modulating drugs using zebrafish larvae.

Sci Rep

2023 Feb 23

Gore SV, Kakodkar R, Del Rosario Hernández T

437. Induction of primordial germ cell-like cells from common marmoset embryonic stem cells by inhibition of WNT and retinoic acid signaling.

Sci Rep

2023 Feb 23

Shono M, Kishimoto K, Hikabe O

438. Deep ensemble learning enables highly accurate classification of stored red blood cell morphology.

Sci Rep

2023 Feb 23

Routt AH, Yang N, Piety NZ

Changes in red blood cell (RBC) morphology distribution have emerged as a quantitative biomarker for the degradation of RBC functional properties during hypothermic storage. Previously published automated methods for classifying the morphology of stored RBCs often had insufficient accuracy and relied on proprietary code and datasets, making them difficult to use in many research and clinical applications. Here we describe the development and validation of a highly accurate open-source RBC morphology classification pipeline based on ensemble deep learning (DL). The DL-enabled pipeline utilized adaptive thresholding or semantic segmentation for RBC identification, a deep ensemble of four convolutional neural networks (CNNs) to classify RBC morphology, and Kalman filtering with Hungarian assignment for tracking changes in the morphology of individual RBCs over time. The ensembled CNNs were trained and evaluated on thousands of individual RBCs from two open-access datasets previously collected to quantify the morphological heterogeneity and washing-induced shape recovery of stored RBCs. Confusion matrices and reliability diagrams demonstrated under-confidence of the constituent models and an accuracy of about 98% for the deep ensemble. Such a high accuracy allowed the CNN ensemble to uncover new insights over our previously published studies. Re-analysis of the datasets yielded much more accurate distributions of the effective diameters of stored RBCs at each stage of morphological degradation (discocyte: 7.821 ± 0.429 µm, echinocyte 1: 7.800 ± 0.581 µm, echinocyte 2: 7.304 ± 0.567 µm, echinocyte 3: 6.433 ± 0.490 µm, sphero-echinocyte: 5.963 ± 0.348 µm, spherocyte: 5.904 ± 0.292 µm, stomatocyte: 7.080 ± 0.522 µm). The effective diameter distributions were significantly different across all morphologies, with considerable effect sizes for non-neighboring classes. A combination of morphology classification with cell tracking enabled the discovery of a relatively rare and previously overlooked shape recovery of some sphero-echinocytes to early-stage echinocytes after washing with 1% human serum albumin solution. Finally, the datasets and code have been made freely available online to enable replication, further improvement, and adaptation of our work for other applications.

439. Changes of biomarkers for erythropoiesis, iron metabolism, and FGF23 by supplementation with roxadustat in patients on hemodialysis.

Sci Rep

2023 Feb 23

Yoshida S, Saito T, Shibagaki K

440. Angiotensin receptor-neprilysin inhibitor delays progression from paroxysmal to persistent atrial fibrillation.

Sci Rep

2023 Feb 23

Dong Y(#), Zhai Z(#), Wang J(#)

441. Osteoprotegerin deficiency aggravates methionine-choline-deficient diet-induced nonalcoholic steatohepatitis in mice.

Sci Rep

2023 Feb 23

Wu S(#), Wu Y(#), Lin L

442. The amniotic fluid proteome changes with term labor and informs biomarker discovery in maternal plasma.

Sci Rep

2023 Feb 23

Bhatti G, Romero R, Gomez-Lopez N

443. The predictive model for risk of chemotherapy-induced thrombocytopenia based on antineoplastic drugs for solid tumors in eastern China.

Sci Rep

2023 Feb 23

Zhou S, Song B, Li C

444. Expanded profiling of Remdesivir as a broad-spectrum antiviral and low potential for interaction with other medications in vitro.

Sci Rep

2023 Feb 23

Radoshitzky SR, Iversen P, Lu X

445. Independence and upper extremity functioning after spinal cord injury: a cross-sectional study.

Sci Rep

2023 Feb 23

Lili L, Sunnerhagen KS, Rekand T

446. Antibacterial and antioxidant double-layered nanofibrous mat promotes wound healing in diabetic rats.

Sci Rep

2023 Feb 23

Nejaddehbashi F, Rafiee Z, Orazizadeh M

447. Implementation of a free water protocol at a long term acute care hospital.

Sci Rep

2023 Feb 23

Gaidos S, Hrdlicka HC, Corbett J.

448. Mycobacterium bovis BCG increase the selected determinants of monocyte/macrophage activity, which were diminished in response to gastric pathogen Helicobacter pylori.

Sci Rep

2023 Feb 22

Gonciarz W, Chyb M, Chmiela M.

449. Taxonomic composition, community structure and molecular novelty of microeukaryotes in a temperate oligomesotrophic lake as revealed by metabarcoding.

Sci Rep

2023 Feb 22

Mitsi K, Richter DJ, Arroyo AS

450. Ostreopsis Schmidt and Coolia Meunier (Dinophyceae, Gonyaulacales) from Cook Islands and Niue (South Pacific Ocean), including description of Ostreopsis tairoto sp. nov.

Sci Rep

2023 Feb 22

Verma A, Hoppenrath M, Smith KF

451. Molecular identification and antiprotozoal activity of silver nanoparticles on viability of Cryptosporidium parvum isolated from pigeons, pigeon fanciers and water.

Sci Rep

2023 Feb 22

Abou Elez RMM, Attia ASA, Tolba HMN

Cryptosporidium is a protozoan that causes acute gastroenteritis, abdominal pain, and diarrhea in many vertebrate species, including humans, animals and birds. A number of studies have reported the occurrence of Cryptosporidium in domestic pigeons. Thus, this study aimed to identify Cryptosporidium spp. in samples collected from domestic pigeons, pigeon fanciers, and drinking water, as well as to investigate the antiprotozoal activity of biosynthesized silver nanoparticles (AgNPs) on the viability of isolated Cryptosporidium parvum (C. parvum). Samples were collected from domestic pigeons (n = 150), pigeon fanciers (n = 50), and drinking water (n = 50) and examined for the presence of Cryptosporidium spp. using microscopic and molecular techniques. The antiprotozoal activity of AgNPs was then assessed both in vitro and in vivo. Cryptosporidium spp. was identified in 16.4% of all examined samples, with C. parvum identified in 5.6%. The highest frequency of isolation was from domestic pigeon, rather than from pigeon fanciers or drinking water. In domestic pigeons, there was a significant association between Cryptosporidium spp. positivity and pigeon's age, droppings consistency, housing, hygienic and heath conditions. However, Cryptosporidium spp. positivity was only significantly associated with pigeon fanciers' gender and heath condition. The viability of C. parvum oocysts was reduced using AgNPs at various concentrations and storage times in a descending manner. In an in vitro study, the highest reduction in C. parvum count was observed at the AgNPs concentration of 1000 µg/mL after a 24 h contact time, followed by the AgNPs concentration of 500 µg/mL after a 24 h contact time. However, after a 48 h contact time, a complete reduction was observed at both 1000 and 500 µg/mL concentrations. Overall, the count and viability of C. parvum decreased with increasing the AgNPs concentration and contact times in both the in vitro and in vivo studies. Furthermore, the C. parvum oocyst destruction was time-dependent and increased with increasing the contact time at various AgNPs concentrations.

452. Investigating valley-dependent current generation due to asymmetric energy dispersion for charge-transfer from a quantum dot to single-walled carbon nanotube.

Sci Rep

2023 Feb 22

Charoenpakdee J, Suntijitrungruang O, Boonchui S.

Single-wall carbon nanotubes (SWCNT), which consist of a two-dimensional hexagonal lattice of carbon atoms, possess unique mechanical, electrical, optical and thermal properties. SWCNT can be synthesized in diverse chiral indexes to determine certain attributes. This work theoretically investigates electron transport in different directions along SWCNT. The electron studied in this research transfers from the quantum dot that can possibly move to the right or left direction in SWCNT with different valley-dependent probability. These results show that valley polarized current is present. The valley current in the right and left directions has a composition of valley degrees of freedom where its components (K and K') are not identical. Such a result can be traced theoretically by certain effects. That firstly is the curvature effect on SWCNT in which the hopping integral between [Formula: see text] electrons from the flat graphene is altered, and another is curvature-inducing [Formula: see text] mixture. Due to these effects, the band structure of SWCNT is asymmetric in certain chiral indexes leading to the asymmetry of valley electron transport. Our results exhibit that the zigzag chiral indexes is the only type making electron transport symmetrical that is different to the result from the other chiral index types which are the armchair and chiral. This work also illustrates the characteristic of the electron wave function propagating from the initial point to the tip of the tube over time, and the current density of the probability in specific times. Additionally, our research simulates the result from the dipole interaction between the electron in QD and the tube that impacts the lifetime of the electron being in QD. The simulation portrays that more dipole interaction encourages the electron transfer to the tube, thereby shortening the lifetime. We as well suggest the reversed electron transfer from the tube to QD that the time duration of such transfer is much less than the opposite transfer owing to the different orbital of the electron's states. Valley polarized current in SWCNTs may also be used in the development of energy storage devices such as batteries and supercapacitors. The performance and effectiveness of nanoscale devices, including transistors, solar cells, artificial antennas, quantum computers, and nano electronic circuits, must be improved in order to achieve a variety of benefits.

453. Identification of Parkinson's disease-associated chromatin regulators.

Sci Rep

2023 Feb 22

Xing H, Wang S, Li K.

454. Cold atmospheric microwave plasma (CAMP) stimulates dermal papilla cell proliferation by inducing β-catenin signaling.

Sci Rep

2023 Feb 22

Mongkolpobsin K(#), Sillapachaiyaporn C(#), Lertpatipanpong P

455. GRIM-19 in asthenozoospermia regulates GC-2 spd cell proliferation, apoptosis and migration.

Sci Rep

2023 Feb 22

Li F, Niu A, Zhao K

456. A fast vanishing point detection method based on row space features suitable for real driving scenarios.

Sci Rep

2023 Feb 22

Yang Q, Ma Y, Li L

457. A new paradigm of reliable sensing with field-deployed electrochemical sensors integrating data redundancy and source credibility.

Sci Rep

2023 Feb 22

Saha A, Sedaghat S, Gopalakrishnan S

For a continuous healthcare or environmental monitoring system, it is essential to reliably sense the analyte concentration reported by electrochemical sensors. However, environmental perturbation, sensor drift, and power-constraint make reliable sensing with wearable and implantable sensors difficult. While most studies focus on improving sensor stability and precision by increasing the system's complexity and cost, we aim to address this challenge using low-cost sensors. To obtain the desired accuracy from low-cost sensors, we borrow two fundamental concepts from communication theory and computer science. First, inspired by reliable data transmission over a noisy communication channel by incorporating redundancy, we propose to measure the same quantity (i.e., analyte concentration) with multiple sensors. Second, we estimate the true signal by aggregating the output of the sensors based on their credibility, a technique originally developed for "truth discovery" in social sensing applications. We use the Maximum Likelihood Estimation to estimate the true signal and the credibility index of the sensors over time. Using the estimated signal, we develop an on-the-fly drift-correction method to make unreliable sensors reliable by correcting any systematic drifts during operation. Our approach can determine solution pH within 0.09 pH for more than three months by detecting and correcting the gradual drift of pH sensors as a function of gamma-ray irradiation. In the field study, we validate our method by measuring nitrate levels in an agricultural field onsite over 22 days within 0.06 mM of a high-precision laboratory-based sensor. We theoretically demonstrate and numerically validate that our approach can estimate the true signal even when the majority (~ 80%) of the sensors are unreliable. Moreover, by restricting wireless transmission to high-credible sensors, we achieve near-perfect information transfer at a fraction of the energy cost. The high-precision sensing with low-cost sensors at reduced transmission cost will pave the way for pervasive in-field sensing with electrochemical sensors. The approach is general and can improve the accuracy of any field-deployed sensors undergoing drift and degradation during operation.

458. Targeting DNA repair pathways with B02 and Nocodazole small molecules to improve CRIS-PITCh mediated cassette integration in CHO-K1 cells.

Sci Rep

2023 Feb 22

Rahmani B, Kheirandish MH, Ghanbari S

459. V(2)CT(X) MXene-based hybrid sensor with high selectivity and ppb-level detection for acetone at room temperature.

Sci Rep

2023 Feb 22

Majhi SM, Ali A, Greish YE

460. The Cenomanian/Turonian boundary in light of new developments in terrestrial palynology.

Sci Rep

2023 Feb 22

Galasso F, Heimhofer U, Schneebeli-Hermann E.

461. Development of the automated temperature control system of the main gas pipeline.

Sci Rep

2023 Feb 22

Fetisov V, Ilyushin YV, Vasiliev GG

462. Comparison of RT-qPCR and RT-ddPCR with Rift valley fever virus (RVFV) RNA.

Sci Rep

2023 Feb 22

Park C, Park D, Hassan ZU

463. Contributors to self-report motor function after anterior cruciate ligament reconstruction.

Sci Rep

2023 Feb 22

Niederer D, Mengis N, Wießmeier M

Numerous functional factors may interactively contribute to the course of self-report functional abilities after anterior cruciate ligament (ACL)-reconstruction. This study purposes to identify these predictors using exploratory moderation-mediation models in a cohort study design. Adults with post unilateral ACL reconstruction (hamstring graft) status and who were aiming to return to their pre-injury type and level of sport were included. Our dependent variables were self-reported function, as assessed by the the KOOS subscales sport (SPORT), and activities of daily living (ADL). The independent variables assessed were the KOOS subscale pain and the time since reconstruction [days]. All other variables (sociodemographic, injury-, surgery-, rehabilitation-specific, kinesiophobia (Tampa Scale of Kinesiophobia), and the presence or absence of COVID-19-associated restrictions) were further considered as moderators, mediators, or co-variates. Data from 203 participants (mean 26 years, SD 5 years) were finally modelled. Total variance explanation was 59% (KOOS-SPORT) and 47% (KOOS-ADL). In the initial rehabilitation phase (< 2 weeks after reconstruction), pain was the strongest contributor to self-report function (KOOS-SPORT: coefficient: 0.89; 95%-confidence-interval: 0.51 to 1.2 / KOOS-ADL: 1.1; 0.95 to 1.3). In the early phase (2-6 weeks after reconstruction), time since reconstruction [days] was the major contributor (KOOS-SPORT: 1.1; 0.14 to 2.1 / KOOS-ADL: 1.2; 0.43 to 2.0). Starting with the mid-phases of the rehabilitation, self-report function was no longer explicitly impacted by one or more contributors. The amount of rehabilitation [minutes] is affected by COVID-19-associated restrictions (pre-versus-post: - 672; - 1264 to - 80 for SPORT / - 633; - 1222 to - 45 for ADL) and by the pre-injury activity scale (280; 103 to 455 / 264; 90 to 438). Other hypothesised contributors such as sex/gender or age were not found to mediate the time or pain, rehabilitation dose and self-report function triangle. When self-report function is rated after an ACL reconstruction, the rehabilitation phases (early, mid, late), the potentially COVID-19-associated rehabilitation limitations, and pain intensity should also be considered. As, for example, pain is the strongest contributor to function in the early rehabilitation phase, focussing on the value of the self-report function only may, consequently, not be sufficient to rate bias-free function.

464. Catalyst free one pot three components synthesis of 2-iminothiazoles from nitroepoxides and thiourea.

Sci Rep

2023 Feb 22

Badali E, Ziyaei Halimehjani A, Habibi A.

465. Reconstitution of human pyroptotic cell death in Saccharomyces cerevisiae.

Sci Rep

2023 Feb 22

Ji Y, Hawkins CJ.

466. Retinal and peripapillary vascular deformations in prematurely born children aged 4-12 years with a history of retinopathy of prematurity.

Sci Rep

2023 Feb 22

Lee GI(#), Park KA(#), Oh SY

467. Anomalous kinetic study of atenolol release from ATN@DNA a core-shell like structure.

Sci Rep

2023 Feb 22

Hefny MM, Elmezayyen AS, Tawfik AM.

468. Exploring soil bacterial diversity in different micro-vegetational habitats of Dachigam National Park in North-western Himalaya.

Sci Rep

2023 Feb 22

Mushtaq H, Ganai BA, Jehangir A.

469. Assessing the impact of one million COVID-19 deaths in America: economic and life expectancy losses.

Sci Rep

2023 Feb 22

Silva S, Goosby E, Reid MJA.

470. Improving the efficiency of dye-sensitized solar cells based on rare-earth metal modified bismuth ferrites.

Sci Rep

2023 Feb 22

Khan M, Iqbal MA(#), Malik M(#)

471. Composition and electronic structure of [Formula: see text]/[Formula: see text]/Al passivating carrier selective contacts on n-type silicon solar cells.

Sci Rep

2023 Feb 22

Flathmann C, Meyer T, Titova V

472. Carbon nanotubes and nanobelts as potential materials for biosensor.

Sci Rep

2023 Feb 22

Monavari SM, Marsusi F, Memarian N

473. Rational thinking as a mediator of the relationship between mindfulness and dental anxiety.

Sci Rep

2023 Feb 22

Yao J, Carciofo R, Pan L.

474. ANFIS-based forming limit prediction of stainless steel 316 sheet metals.

Sci Rep

2023 Feb 22

Zhang M, Meng Z, Shariati M.

475. Uncovering the complex genetic architecture of human plasma lipidome using machine learning methods.

Sci Rep

2023 Feb 22

Lehtimäki M(#), Mishra BH(#), Del-Val C

476. Non-invasive monitoring of T cell differentiation through Raman spectroscopy.

Sci Rep

2023 Feb 22

Pavillon N, Smith NI.

477. A nomogram predictive model for long-term survival in spontaneous intracerebral hemorrhage patients without cerebral herniation at admission.

Sci Rep

2023 Feb 22

Lin F(#), He Q(#), Zhuo L(#)

Stratification of spontaneous intracerebral hemorrhage (sICH) patients without cerebral herniation at admission, to determine the subgroups may be suffered from poor outcomes or benefit from surgery, is important for following treatment decision. The aim of this study was to establish and verify a de novo nomogram predictive model for long-term survival in sICH patients without cerebral herniation at admission. This study recruited sICH patients from our prospectively maintained ICH patient database (RIS-MIS-ICH, ClinicalTrials.gov Identifier: NCT03862729) between January 2015 and October 2019. All eligible patients were randomly classified into a training cohort and a validation cohort according to the ratio of 7:3. The baseline variables and long-term survival outcomes were collected. And the long-term survival information of all the enrolled sICH patients, including the occurrence of death and overall survival. Follow-up time was defined as the time from the onset to death of the patient or the last clinical visit. The nomogram predictive model was established based on the independent risk factors at admission for long-term survival after hemorrhage. The concordance index (C-index) and ROC curve were used to evaluate the accuracy of the predictive model. Discrimination and calibration were used to validate the nomogram in both the training cohort and the validation cohort. A total of 692 eligible sICH patients were enrolled. During the average follow-up time of 41.77 ± 0.85 months, a total of 178 (25.7%) patients died. The Cox Proportional Hazard Models showed that age (HR 1.055, 95% CI 1.038-1.071, P < 0.001), Glasgow Coma Scale (GCS) at admission (HR 2.496, 95% CI 2.014-3.093, P < 0.001) and hydrocephalus caused by intraventricular hemorrhage (IVH) (HR 1.955, 95% CI 1.362-2.806, P < 0.001) were independent risk factors. The C index of the admission model was 0.76 and 0.78 in the training cohort and validation cohort, respectively. In the ROC analysis, the AUC was 0.80 (95% CI 0.75-0.85) in the training cohort and was 0.80 (95% CI 0.72-0.88) in the validation cohort. SICH patients with admission nomogram scores greater than 87.75 were at high risk of short survival time. For sICH patients without cerebral herniation at admission, our de novo nomogram model based on age, GCS and hydrocephalus on CT may be useful to stratify the long-term survival outcomes and provide suggestions for treatment decision-making.

478. Neuroendocrine and psychophysiological investigation of the evolutionary roots of gossip.

Sci Rep

2023 Feb 22

Rudnicki K, Spacova I, Backer C

479. The spatio-temporal distribution of alkaline phosphatase activity and phoD gene abundance and diversity in sediment of Sancha Lake.

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2023 Feb 22

Li Y, Yu X, Liu H

The bacterial phoD gene encoding alkaline phosphatase (ALP) plays an important role in the release of soluble reactive phosphorus (SRP) from organic phosphorus in ecosystems. However, phoD gene diversity and abundance in ecosystems is poorly understood. In the present study, we sampled the surface sediments and the overlying water of Sancha Lake at 9 different sampling sites, a typical eutrophic sub-deep freshwater lake in China, in April 15 (spring) and November 3 (autumn), 2017. High-throughput sequencing and qPCR were performed to analyze the diversity and abundance of the bacterial phoD gene in the sediments. We further discussed the relationships between the diversity and abundance of the phoD gene and environmental factors and ALP activity. A total of 881,717 valid sequences were obtained from 18 samples and were classified into 41 genera, 31 families, 23 orders, 12 classes, and 9 phyla and grouped into 477 OTUs. The dominant phyla were Proteobacteria and Actinobacteria. The phylogenetic tree based on the sequences of the phoD gene was plotted and composed of three branches. The genetic sequences were aligned predominantly with genera Pseudomonas, Streptomyces, Cupriavidus, and Paludisphaer. The phoD-harboring bacterial community structure showed a significant difference in spring and autumn, but no apparent spatial heterogeneity. The phoD gene abundances at different sampling points were significantly higher in autumn than in spring. In autumn and spring, the phoD gene abundance was significantly higher in the tail of lake and where cage culture used to be intensive. pH value, dissolved oxygen (DO), total organic carbon (TOC), ALP, and phosphorus were important environmental factors affecting the diversity of the phoD gene and the phoD-harboring bacterial community structure. Changes in phoD-harboring bacterial community structure, phoD gene abundance, and ALP activity were negatively correlated with SRP in overlying water. Our study indicated phoD-harboring bacteria in the sediments of Sancha Lake with the characteristics of high diversity and significant spatial and temporal heterogeneity in abundance and community structure, which played a important role in the release of SRP.

480. Germline VWF/MPRIP and somatoplasm FGA variants synergically confer susceptibility to non-traumatic osteonecrosis of the femoral head.

Sci Rep

2023 Feb 22

Wang D(#), Gu L(#), Zheng J(#)

481. Reliability and validity of ultrasonographic automated length measurement system for assessing talofibular anterior instability in acute lateral ankle sprain.

Sci Rep

2023 Feb 22

Kawabata M, Kumazawa Y, Takagi K

482. Apparent increase in lip size influences two-point discrimination.

Sci Rep

2023 Feb 22

Ambron E, Coslett HB.

483. Evaluation and classification of obfuscated Android malware through deep learning using ensemble voting mechanism.

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2023 Feb 22

Aurangzeb S, Aleem M.

484. An underexploited invisible gold resource in the Archean sulphides of the Witwatersrand tailings dumps.

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2023 Feb 22

Chingwaru SJ, Von der Heyden B, Tadie M.

485. An ultralow-cost portable centrifuge from discarded materials for medical applications.

Sci Rep

2023 Feb 22

Franco JJ(#), Nagata T(#), Okamoto T

486. Acquired radioresistance in EMT6 mouse mammary carcinoma cell line is mediated by CTLA-4 and PD-1 through JAK/STAT/PI3K pathway.

Sci Rep

2023 Feb 22

Sham NFR, Hasani NAH, Hasan N

487. Diverse flower-visiting responses among pollinators to multiple weather variables in buckwheat pollination.

Sci Rep

2023 Feb 22

Miyashita T, Hayashi S, Natsume K

488. Prevalence of family history of cancer in the NC-CCAPH consortium of Japan.

Sci Rep

2023 Feb 22

Abe SK, Ihira H, Minami T

489. Effects of exogenous oxytocin and estradiol on resting-state functional connectivity in women and men.

Sci Rep

2023 Feb 22

Coenjaerts M, Adrovic B, Trimborn I

490. In vitro to clinical translational pharmacokinetic/pharmacodynamic modeling of doxorubicin (DOX) and dexrazoxane (DEX) interactions: Safety assessment and optimization.

Sci Rep

2023 Feb 22

Mody H(#), Vaidya TR(#), Ait-Oudhia S.

491. Inhibition of norepinephrine signaling during a sensitive period disrupts locus coeruleus circuitry and emotional behaviors in adulthood.

Sci Rep

2023 Feb 22

Meng Q(#), Garcia-Garcia AL(#), Dranovsky A

492. Application of self-organizing maps to AFM-based viscoelastic characterization of breast cancer cell mechanics.

Sci Rep

2023 Feb 22

Weber A, Vivanco MD, Toca-Herrera JL.

493. Once a week consumption of Western diet over twelve weeks promotes sustained insulin resistance and non-alcoholic fat liver disease in C57BL/6 J mice.

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2023 Feb 21

Demaria TM(#), Crepaldi LD(#), Costa-Bartuli E

494. The magnetic field strength and the force distance dependency of the magnetically controlled growing rods used for early onset scoliosis.

Sci Rep

2023 Feb 21

Diekhöner L, Meyer CS, Eiskjær S.

495. Transcranial high-frequency random noise stimulation does not modulate Nogo N2 and Go/Nogo reaction times in somatosensory and auditory modalities.

Sci Rep

2023 Feb 21

Yamashiro K, Ikarashi K, Makibuchi T

496. A maximum entropy approach for the modelling of car-sharing parking dynamics.

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2023 Feb 21

Daniotti S, Monechi B, Ubaldi E.

The science of cities is a relatively new and interdisciplinary topic aimed at studying and characterizing the collective processes that shape the growth and dynamics of urban populations. Amongst other open problems, the forecast of mobility trends in urban spaces is a lively research topic that aims at assisting the design and implementation of efficient transportation policies and inclusive urban planning. To this end, many Machine-Learning models have been put forward to predict mobility patterns. However, most of them are not interpretable -as they build on complex hidden representations of the system configurations- or do not allow for model inspection, thus limiting our understanding of the underlying mechanisms driving the citizen's daily routines. Here, we tackle this problem by building a fully interpretable statistical model that, incorporating only the minimum number of constraints, can predict different phenomena arising in the city. Using data on the movements of car-sharing vehicles in several Italian cities, we infer a model using the Maximum Entropy (MaxEnt) principle. The model allows for an accurate spatio-temporal prediction of car-sharing vehicles' presence in different city areas and, thanks to its simple yet general formulation, to precisely perform anomaly detection (e.g., detect strikes and bad weather conditions from car-sharing data only). We compare the forecasting capabilities of our model with different state-of-the-art models explicitly made for time-series forecasting: SARIMA models and Deep Learning Models. We find that MaxEnt models are highly predictive, outperforming SARIMAs while having similar performances of deep Neural Networks - but with advantages of being more interpretable, more flexibile-i.e., they can be applied to different tasks- and being computationally efficient. Our results show that statistical inference might play a fundamental role in building robust and general models describing urban systems phenomena.

497. A novel transgenic mouse model expressing primate-specific nuclear choline acetyltransferase: insights into potential cholinergic vulnerability.

Sci Rep

2023 Feb 21

AlQot HE, Rylett RJ.

498. Mechanical properties and biocompatibility of a novel miniscrew made of Zr(70)Ni(16)Cu(6)Al(8) bulk metallic glass for orthodontic anchorage.

Sci Rep

2023 Feb 21

Sasaki S, Seiryu M, Ida H

499. RCS reduction using grounded multi-height multi-dielectrics metasurfaces.

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2023 Feb 21

Heidari M, Sedighy SH, Amirhosseini MK.

500. MosChito rafts as effective and eco-friendly tool for the delivery of a Bacillus thuringiensis-based insecticide to Aedes albopictus larvae.

Sci Rep

2023 Feb 21

Pitton S(#), Negri A(#), Pezzali G

501. Molecular biological features of cyst wall of adamantinomatous craniopharyngioma.

Sci Rep

2023 Feb 21

Zhao C(#), Wang Y(#), Liu H

502. A comparison of experience sampled hay fever symptom severity across rural and urban areas of the UK.

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2023 Feb 21

Gledson A, Lowe D, Reani M

503. Impact of mobile health on maternal and child health service utilization and continuum of care in Northern Ghana.

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2023 Feb 21

Nuhu AGK, Dwomoh D, Amuasi SA

504. Mutation in Smek2 regulating hepatic glucose metabolism causes hypersarcosinemia and hyperhomocysteinemia in rats.

Sci Rep

2023 Feb 21

Tanaka Y(#), Kawano M(#), Nakashima S

505. Spectro-temporal acoustic elements of music interact in an integrated way to modulate emotional responses in pigs.

Sci Rep

2023 Feb 21

Zapata Cardona J, Ceballos MC, Tarazona Morales AM

506. Metasurfaces of capacitively loaded metallic rings for magnetic resonance imaging surface coils.

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2023 Feb 21

Freire MJ.

This work investigates the use of a metasurface made up of a two-dimensional array of capacitively loaded metallic rings to enhance the signal-to-noise ratio of magnetic resonance imaging surface coils and to tailor the magnetic near-field radio frequency pattern of the coils. It is found that the signal-to-noise ratio is increased if the coupling between the capacitively loaded metallic rings in the array is increased. The input resistance and the radiofrequency magnetic field of the metasurface loaded coil are numerically analyzed by means of an efficient algorithm termed the discrete model to determine the signal-to-noise ratio. Standing surface waves or magnetoinductive waves supported by the metasurface introduce resonances in the frequency dependence of the input resistance. The signal-to-noise ratio is found to be optimal at the frequency corresponding to a local minimum existing between these resonances.The discrete model is used in an optimization procedure to fit the structural parameters of a metasurface to enhance the signal-to-noise ratio at the frequency corresponding to this local minimum in the input resistance. It is found that the signal-to-noise ratio can be greatly improved if the mutual coupling between the capacitively loaded metallic rings of the array is made stronger by bringing them closer or by using rings of squared shape instead of circular. These conclusions derived from the numerical results provided by the discrete model are double-checked by means of numerical simulations provided by the commercial electromagnetic solver Simulia CST and by experimental results. Numerical results provided by CST are also shown to demonstrate that the surface impedance of the array of elements can be adjusted to provide a more homogeneous magnetic near-field radio frequency pattern that ultimately leads to a more uniform magnetic resonance image at a desired slice. This is achieved by preventing the reflection of propagating magnetoinductive waves at the edges of the array by matching the elements arranged at the edges of the array with capacitors of suitable value.

507. Structural equation modeling of direct and indirect associations of social media addiction with eating behavior in adolescents and young adults.

Sci Rep

2023 Feb 21

Mohsenpour MA, Karamizadeh M, Barati-Boldaji R

508. Effect of bulky anions on the liquid-liquid phase transition in phosphonium ionic liquids: Ambient and high-pressure dielectric studies.

Sci Rep

2023 Feb 21

Yao B, Paluch M, Wojnarowska Z.

509. High thermoelectric performance of flexible nanocomposite films based on Bi(2)Te(3) nanoplates and carbon nanotubes selected using ultracentrifugation.

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2023 Feb 21

Chiba T, Yabuki H, Takashiri M.

510. The impact of hypoxia and oxidative stress on proteo-metabolomic alterations of 3D cholangiocarcinoma models.

Sci Rep

2023 Feb 21

Phukhum P, Phetcharaburanin J, Chaleekarn K

511. Sunsetting Binding MOAD with its last data update and the addition of 3D-ligand polypharmacology tools.

Sci Rep

2023 Feb 21

Wagle S, Smith RD, Dominic AJ 3rd

512. The importance of batch sensitization in missing value imputation.

Sci Rep

2023 Feb 21

Hui HWH(#), Kong W(#), Peng H

513. Characterization of sinoatrial automaticity in Microcebus murinus to study the effect of aging on cardiac activity and the correlation with longevity.

Sci Rep

2023 Feb 21

DiFrancesco ML, Marrot M, Torre E

514. Modified unified critical state model for soils considering over-consolidation and cyclic loading behaviours.

Sci Rep

2023 Feb 21

Wang X, Yuan R, Cui K.

515. Mammalian pumilio proteins control cellular morphology, migration, and adhesion.

Sci Rep

2023 Feb 21

Sternburg EL, Lillibridge JJ, Phandthong R

516. Spherical rotary cell seeding system for production of small-caliber tissue-engineered blood vessels with complex geometry.

Sci Rep

2023 Feb 21

Brodeur A, Winter A, Roy V

517. Non-synonymous variation and protein structure of candidate genes associated with selection in farm and wild populations of turbot (Scophthalmus maximus).

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2023 Feb 21

Andersen Ø, Rubiolo JA, Pirolli D

518. High and low worriers do not differ in unstimulated resting-state brain connectivity.

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2023 Feb 21

Weber-Goericke F, Muehlhan M.

519. Extracellular vesicles released from macrophages modulates interleukin-1β in astrocytic and neuronal cells.

Sci Rep

2023 Feb 21

Kodidela S, Sinha N, Kumar A

520. Quality prediction and classification of resistance spot weld using artificial neural network with open-sourced, self-executable and GUI-based application tool Q-Check.

Sci Rep

2023 Feb 21

Abd Halim S, Manurung YHP, Raziq MA

521. Rodent activity in municipal waste collection premises in Singapore: an analysis of risk factors using mixed-effects modelling.

Sci Rep

2023 Feb 21

Soh S, Chua CH, Neo ZW

522. Heat and mass transfer of micropolar liquid flow due to porous stretching/shrinking surface with ternary nanoparticles.

Sci Rep

2023 Feb 21

Vanitha GP, Mahabaleshwar US, Hatami M

523. Efficient and accurate KRAS genotyping using digital PCR combined with melting curve analysis for ctDNA from pancreatic cancer patients.

Sci Rep

2023 Feb 21

Tanaka J, Nakagawa T, Harada K

524. An experimental and numerical study of twin dowel type shear connector.

Sci Rep

2023 Feb 21

Vanova P, Dubecky D, Weissova M

525. Evaluation of cellular water exchange in a mouse glioma model using dynamic contrast-enhanced MRI with two flip angles.

Sci Rep

2023 Feb 21

Kiser K, Zhang J, Das AB

526. Systematic analysis identifies REST as an oncogenic and immunological biomarker in glioma.

Sci Rep

2023 Feb 21

Wang G, Yang X, Qi M

The repressor element 1 silencing transcription factor (REST) has been proposed to function as a transcription factor to silence gene transcription by binding to repressor element 1 (RE1), a highly conserved DNA motif. The functions of REST in various tumors have been studied, but its role and correlation with immune cell infiltration remains uncertain in gliomas. REST expression was analyzed in datasets of The Cancer Genome Atlas (TCGA) and the Genotype-Tissue Expression (GTEx) and validated by the Gene Expression Omnibus and Human Protein Atlas databases. The clinical prognosis of REST was evaluated by clinical survival data of TCGA cohort and validated by Chinese Glioma Genome Atlas cohort. MicroRNAs (miRNAs) contributing to REST overexpression in glioma were identified by a combination of a series of in silico analyses, including expression analysis, correlation analysis, and survival analysis. The correlations between immune cell infiltration level and REST expression were analyzed by TIMER2 and GEPIA2 tools. Enrichment analysis of REST was performed using STRING and Metascape tools. The expression and function of predicted upstream miRNAs at REST and their association with glioma malignancy and migration were also confirmed in glioma cell lines. REST was highly expressed and associated with poorer overall survival and disease-specific survival in glioma and some other tumors. MiR-105-5p and miR-9-5p were identified as the most potential upstream miRNAs of REST in glioma patient cohort and experiments in vitro. REST expression was positively correlated with infiltration of immune cells and the expression of immune checkpoints such as PD1/PD-L1 and CTLA-4 in glioma. Furthermore, histone deacetylase 1 (HDAC1) was a potential REST-related gene in glioma. Enrichment analysis of REST found chromatin organization and histone modification were the most significant enriched terms, and Hedgehog-Gli pathway might be involved in the effect of REST on the pathogenesis of glioma. Our study suggests REST to be an oncogenic gene and the biomarker of poor prognosis in glioma. High REST expression might affect the tumor microenvironment of glioma. More basic experiments and large clinical trials aimed at the carcinogenetic study of REST in glioma will be needed in the future.

527. The influence of astrocytic leaflet motility on ionic signalling and homeostasis at active synapses.

Sci Rep

2023 Feb 21

Toman M, Wade JJ, Verkhratsky A

528. Cancer-associated fibroblasts are the main contributors to epithelial-to-mesenchymal signatures in the tumor microenvironment.

Sci Rep

2023 Feb 21

Szabo PM, Vajdi A, Kumar N

529. Implementation and performance analysis of QPSK system using pocket double gate asymmetric JLTFET for satellite communications.

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2023 Feb 21

Boggarapu L, B L.

This work is intended to design a quadrature phase shift keying (QPSK) system starting from the device design, characterization and optimization which is then followed by the circuit level implementation and finally the system level configuration. Tunnel Field Effect Transistor (TFET) technology came into existence because of the inability of CMOS (Complementary Metal Oxide Semiconductor) to produce reduced leakage current (Ioff) in the subthreshold regime. With the effects of scaling and requirement of high doping concentrations, TFET is not capable to produce stable reduction in Ioff due to the variation in ON and OFF current. To improve the switching ratio of the current and to obtain good subthreshold swing (SS) by overcoming the limitations of junction TFET, a new device design is proposed for the first time in this work. A pocket double gate asymmetric Junction less TFET (poc-DG-AJLTFET) structure has been proposed in which uniform doping is used to eliminate the junctions and a pocket of length 2 nm made of Silicon-Germanium (SiGe) material has been introduced to improve the designed structure performance in the weak inversion region and increase the drive current (ION). The work function has been tuned to produce the best results for poc-DG-AJLTFET and with our proposed poc-DG-AJLTFET, effects of interface traps are eliminated as against conventional JLTFET structures. The notion that low-threshold voltage device yields high IOFF has been proved wrong with our poc-DG-AJLTFET design, as it produced low threshold voltage with lower IOFF which reduced the power dissipation. Numerical results show that drain induced barrier lowering (DIBL) of 2.75 mV/V is achieved which could be less than 35 times required for short channel effects to be minimum. In terms of gate to drain capacitance (Cgd), it is found that ~ 103 reduction which greatly improves device inertia to internal electrical interference. Also, improvement in transconductance is achieved by 104 times, 103 times improvement in ION/IOFF ratio, and 400 times higher unity gain cutoff-frequency (ft) which would be required by all communication systems. The Verilog models of the designed device are used to construct the leaf cells of quadrature phase shift keying (QPSK) system and the implemented QPSK system is taken as a key evaluator in the performance evaluation in terms of propagation delay and power consumption of poc-DG-AJLTFET in modern satellite communication systems.

530. Early detection of anthropogenic climate change signals in the ocean interior.

Sci Rep

2023 Feb 21

Tjiputra JF, Negrel J, Olsen A.

531. Strategies for single-shot discrimination of process matrices.

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2023 Feb 21

Lewandowska P, Pawela Ł, Puchała Z.

532. Decadal cyclical geological atmospheric emissions for a major marine seep field, offshore Coal Oil Point, Southern California.

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2023 Feb 21

Leifer I.

533. Research on longitudinal vibration suppression of underwater vehicle shafting based on particle damping.

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2023 Feb 21

Liu J, Deng T, Chang X

534. Efficient quantization of painting images by relevant colors.

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2023 Feb 21

Tirandaz Z, Foster DH, Romero J

535. Cluster-based psychological phenotyping and differences in anxiety treatment outcomes.

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2023 Feb 21

Taylor VA, Roy A, Brewer JA.

The identification of markers of mental health illness treatment response and susceptibility using personalized medicine has been elusive. In the context of psychological treatment for anxiety, we conducted two studies to identify psychological phenotypes with distinct characteristics related to: psychological intervention modalities (mindfulness training/awareness), mechanism of action (worry), and clinical outcome (generalized anxiety disorder scale scores). We also examined whether phenotype membership interacted with treatment response (Study 1) and mental health illness diagnosis (Studies 1-2). Interoceptive awareness, emotional reactivity, worry, and anxiety were assessed at baseline in treatment-seeking individuals (Study 1, n = 63) and from the general population (Study 2, n = 14,010). In Study 1, participants were randomly assigned to an app-delivered mindfulness program for anxiety for two months or treatment as usual. Changes in anxiety were assessed 1 and 2 months post-treatment initiation. In studies 1-2, three phenotypes were identified: 'severely anxious with body/emotional awareness' (cluster 1), 'body/emotionally unaware' (cluster 2), and 'non-reactive and aware' (cluster 3). Study 1's results revealed a significant treatment response relative to controls (ps < 0.001) for clusters 1 and 3, but not for cluster 2. Chi-square analyses revealed that phenotypes exhibited significantly different proportions of participants with mental health diagnoses (studies 1-2). These results suggest that psychological phenotyping can bring the application of personalized medicine into clinical settings.Registry name and URL: Developing a novel digital therapeutic for the treatment of generalized anxiety disorder https://clinicaltrials.gov/ct2/show/NCT03683472?term=judson+brewer&draw=1&rank=1 .Trial registration: Registered at clinicaltrials.gov (NCT03683472) on 25/09/2018.

536. Exploring the mechanistic pathways of how social network influences social norms in adolescent smoking prevention interventions.

Sci Rep

2023 Feb 21

Montes F, Blanco M, Useche AF

537. The transnasal endoscopic approach for resection of clival tumors: a single-center experience.

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2023 Feb 21

Butenschoen VM, Krauss P, Bernhardt D

538. Fluorescence lifetime imaging through scattering media.

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2023 Feb 21

Nilsson S, Kristensson E, Aldén M

539. Scour ponds from unusually large tsunamis on a beach-ridge plain in eastern Hokkaido, Japan.

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2023 Feb 21

Sawai Y, Tamura T, Shimada Y

540. Joint estimation of relaxation and diffusion tissue parameters for prostate cancer with relaxation-VERDICT MRI.

Sci Rep

2023 Feb 21

Palombo M, Valindria V, Singh S

541. The symmetry in the model of two coupled Kerr oscillators leads to simultaneous multi-photon transitions.

Sci Rep

2023 Feb 21

Nikitchuk BY, Anikin EV, Maslova NS

542. Effect of in vitro cultivation on human gut microbiota composition using 16S rDNA amplicon sequencing and metabolomics approach.

Sci Rep

2023 Feb 21

Średnicka P, Roszko MŁ, Popowski D

543. Uric acid and risk of pre-eclampsia: results from a large case-control study and meta-analysis of prospective studies.

Sci Rep

2023 Feb 21

Colmenares-Mejia CC, Quintero-Lesmes DC, Bautista-Niño PK

544. Risk of systemic lupus erythematosus flares according to autoantibody positivity at the time of diagnosis.

Sci Rep

2023 Feb 21

Kwon OC, Park MC.

545. Upside down sulphate dynamics in a saline inland lake.

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2023 Feb 21

Margalef-Marti R, Sebilo M, Thibault De Chanvalon A

546. Exploring a global interpretation mechanism for deep learning networks when predicting sepsis.

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2023 Feb 21

Strickler EAT, Thomas J, Thomas JP

The purpose of this study is to identify additional clinical features for sepsis detection through the use of a novel mechanism for interpreting black-box machine learning models trained and to provide a suitable evaluation for the mechanism. We use the publicly available dataset from the 2019 PhysioNet Challenge. It has around 40,000 Intensive Care Unit (ICU) patients with 40 physiological variables. Using Long Short-Term Memory (LSTM) as the representative black-box machine learning model, we adapted the Multi-set Classifier to globally interpret the black-box model for concepts it learned about sepsis. To identify relevant features, the result is compared against: (i) features used by a computational sepsis expert, (ii) clinical features from clinical collaborators, (iii) academic features from literature, and (iv) significant features from statistical hypothesis testing. Random Forest was found to be the computational sepsis expert because it had high accuracies for solving both the detection and early detection, and a high degree of overlap with clinical and literature features. Using the proposed interpretation mechanism and the dataset, we identified 17 features that the LSTM used for sepsis classification, 11 of which overlaps with the top 20 features from the Random Forest model, 10 with academic features and 5 with clinical features. Clinical opinion suggests, 3 LSTM features have strong correlation with some clinical features that were not identified by the mechanism. We also found that age, chloride ion concentration, pH and oxygen saturation should be investigated further for connection with developing sepsis. Interpretation mechanisms can bolster the incorporation of state-of-the-art machine learning models into clinical decision support systems, and might help clinicians to address the issue of early sepsis detection. The promising results from this study warrants further investigation into creation of new and improvement of existing interpretation mechanisms for black-box models, and into clinical features that are currently not used in clinical assessment of sepsis.

547. Successful identification of the species of the semipetrified amber medicinal resin benzoin using molecular diagnostic technology.

Sci Rep

2023 Feb 20

Feng J, He Q, Xie A

548. The necessity of incorporating non-genetic risk factors into polygenic risk score models.

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2023 Feb 20

van Dam S(#), Folkertsma P(#), Castela Forte J

549. Controllable Hartman effect by vortex beam in a one dimensional photonic crystal doped by graphene quantum dots.

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2023 Feb 20

Kevin S, Sahrai M, Asadpour SH.

550. The diagnostic and prognostic utility of repetitive nerve stimulation in patients with myasthenia gravis.

Sci Rep

2023 Feb 20

Tomschik M, Renaud E, Jäger F

551. Source apportionment and source-specific risk evaluation of potential toxic elements in oasis agricultural soils of Tarim River Basin.

Sci Rep

2023 Feb 20

Li Y, Abuduwaili J, Ma L

As rapidly developing area of intensive agriculture during the past half century, the oases in the source region of the Tarim River have encountered serious environmental challenges. Therefore, a comparative analysis of soil pollution characteristics and source-specific risks in different oases is an important measure to prevent and control soil pollution and provide guidance for extensive resource management in this area. In this study, the concentration of potential toxic elements (PTEs) was analyzed by collecting soil samples from the four oases in the source region of the Tarim River. The cumulative frequency curve method, pollution index method, positive matrix factorization (PMF) model, geographical detector method and health risk assessment model were used to analyze the pollution status and source-specific risk of potential toxic elements in different oases. The results showed that Cd was the most prominent PTE in the oasis agricultural soil in the source region of the Tarim River. Especially in Hotan Oasis, where 81.25% of the soil samples were moderately contaminated and 18.75% were highly contaminated with Cd. The PTEs in the Hotan Oasis corresponded to a moderate level of risk to the ecological environment, and the noncarcinogenic risk of soil PTEs in the four oases to local children exceeded the threshold (TH > 1), while the carcinogenic risk to local residents was acceptable (1E-06 < TCR < 1E-04). The research results suggested that the Hotan Oasis should be the key area for soil pollution control in the source region of the Tarim River, and agricultural activities and natural sources, industrial sources, and atmospheric dust fall are the priority sources that should be controlled in the Aksu Oasis, Kashgar Oasis and Yarkant River Oasis, respectively. The results of this study provide important decision-making support for the protection and management of regional agricultural soil and the environment.

552. FUS regulates a subset of snoRNA expression and modulates the level of rRNA modifications.

Sci Rep

2023 Feb 20

Gawade K, Plewka P, Häfner SJ

553. Quantifying the impact of the Grain-for-Green Program on ecosystem service scarcity value in Qinghai, China.

Sci Rep

2023 Feb 20

Hu Y, Zhang S, Shi Y

554. Identification of germline cancer predisposition variants in pediatric sarcoma patients from somatic tumor testing.

Sci Rep

2023 Feb 20

Alba-Pavón P(#), Alaña L(#), Gutierrez-Jimeno M

555. An optical coherence tomography and endothelial shear stress study of a novel bioresorbable bypass graft.

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2023 Feb 20

Poon EKW, Ono M, Wu X

556. A tool to enhance antimicrobial stewardship using similarity networks to identify antimicrobial resistance patterns across farms.

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2023 Feb 20

Aguilar-Vega C, Scoglio C, Clavijo MJ

557. The association of ODF4 with AK1 and AK2 in mice is essential for fertility through its contribution to flagellar shape.

Sci Rep

2023 Feb 20

Ito C(#), Makino T, Mutoh T

558. Pixel-by-pixel autofluorescence corrected FRET in fluorescence microscopy improves accuracy for samples with spatially varied autofluorescence to signal ratio.

Sci Rep

2023 Feb 20

Rebenku I, Lloyd CB, Szöllősi J

559. Analysis of gaze patterns during facade inspection to understand inspector sense-making processes.

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2023 Feb 20

Saleem MR, Mayne R, Napolitano R.

560. Impact of COVID-19 lockdown on physical activity, insomnia, and loneliness among Spanish women and men.

Sci Rep

2023 Feb 20

Guerra-Balic M, González-González CS, Sansano-Nadal O

During COVID-19 pandemic, quality of living was impacted by social isolation, loneliness, and altered sleep habits. The aims of this study were (1) to examine the relationship between physical activity (PA) levels with insomnia and loneliness among adults during Spain's first COVID-19 wave of lockdown and its impact on women and (2) to examine the digital technologic resources used to support both PA and other recreational activities in women. A cross-sectional design was used. An anonymous 15-min online survey was conducted in Spain to adults (≥ 18 years old) during the first COVID-19 lockdown, a 40-day period. A snowball distribution method was employed using personal email and social networks (Facebook, Whatsapp, Linkedin, Twitter). Variables studied included: socio-demographic items, insomnia, loneliness, PA, and digital technologic resources. A total of 996 adults (females = 663, 66.6%) completed the survey. Higher education levels were associated with greater PA levels (p-value < 0.001). Women presented with higher insomnia risk than men with low PA levels (OR = 1.9, CI = 1.25; 2.95). Living with family members or other individuals was related to lower insomnia risk. A strong correlation between medium-high PA levels was found with greater digital technology resources (DTS) than individuals with low PA levels. Females used significantly more DTS than males (p-value < 0.001). No significant associations between DTS were found with age or academic education level. PA levels, sex, and loneliness were related to insomnia risk. A strong correlation between PA and DTS use was observed. Participants with medium-high PA levels and females use them more than those with low PA levels and males. We recommend promoting the PA through digital technologies for women. This recommendation would also improve sleep disorders in women who present higher insomnia risks than men.

561. The effect of postmenopausal osteoporosis on subchondral bone pathology in a rat model of knee osteoarthritis.

Sci Rep

2023 Feb 20

Wada H, Aso K, Izumi M

562. Estimability study on the age of toddlers' gait development based on gait parameters.

Sci Rep

2023 Feb 20

Tsuyuki C, Hiraga H, Sudo M

563. Directional asymmetry in gonad length indicates moray eels (Teleostei, Anguilliformes, Muraenidae) are "right-gonadal".

Sci Rep

2023 Feb 20

Lin YJ, Chen HM.

564. Deep learning ensemble 2D CNN approach towards the detection of lung cancer.

Sci Rep

2023 Feb 20

Shah AA, Malik HAM, Muhammad A

565. Long-term visual acuity outcome of pediatric uveitis patients presenting with severe visual impairment.

Sci Rep

2023 Feb 20

Tungsattayathitthan U, Rattanalert N, Sittivarakul W.

566. Presaccadic attention sharpens visual acuity.

Sci Rep

2023 Feb 20

Kwak Y, Hanning NM(#), Carrasco M(#).

567. Protective effect of Anoectochilus burmannicus extracts and its active compound, kinsenoside on adipocyte differentiation induced by benzyl butyl phthalate and bisphenol A.

Sci Rep

2023 Feb 20

Buacheen P(#), Karinchai J(#), Kammasit N

568. Preserved ratio impaired spirometry with or without restrictive spirometric abnormality.

Sci Rep

2023 Feb 20

Miura S, Iwamoto H, Omori K

569. Efficient plasma electron accelerator driven by linearly chirped multi-10-TW laser pulses.

Sci Rep

2023 Feb 20

Grigoriadis A, Andrianaki G, Tazes I

570. A new method for axis adjustment of the hydro-generator unit using machine learning.

Sci Rep

2023 Feb 20

Cao J, Li Y, Qu Z

571. Diversification of the shell shape and size in Baikal Candonidae ostracods inferred from molecular phylogeny.

Sci Rep

2023 Feb 20

Karanovic I, Pham HTM, Sitnikova T.

572. Multiple metrics assessment method for a reliable evaluation of corneal suturing skills.

Sci Rep

2023 Feb 20

Dormegny L, Neumann N, Lejay A

573. Full-visibility 3D imaging of oxygenation and blood flow by simultaneous multispectral photoacoustic fluctuation imaging (MS-PAFI) and ultrasound Doppler.

Sci Rep

2023 Feb 20

Godefroy G, Arnal B, Bossy E.

574. Environmental and pathological factors affecting the hatching success of the two northernmost loggerhead sea turtle (Caretta caretta) nests.

Sci Rep

2023 Feb 20

Pietroluongo G, Centelleghe C, Sciancalepore G

575. Improving morphology and optoelectronic properties of ultra-wide bandgap perovskite via Cs tuning for clear solar cell and UV detection applications.

Sci Rep

2023 Feb 20

Tun MZ, Pansa-Ngat P, Ruankham P

576. Frequency-specific brain network architecture in resting-state fMRI.

Sci Rep

2023 Feb 20

Kajimura S, Margulies D, Smallwood J.

577. Identification and prediction of mixed-use functional areas supported by POI data in Jinan City of China.

Sci Rep

2023 Feb 20

Zheng M, Wang H, Shang Y

578. Long-term health-related quality of life after trauma with and without traumatic brain injury: a prospective cohort study.

Sci Rep

2023 Feb 20

Kiwanuka O, Lassarén P, Thelin EP

579. Socioeconomic inequality in awareness, treatment and control of diabetes among adults in India: Evidence from National Family Health Survey of India (NFHS), 2019-2021.

Sci Rep

2023 Feb 20

Maiti S, Akhtar S, Upadhyay AK

Diabetes is a growing epidemic and a major threat to most of the households in India. Yet, there is little evidence on the extent of awareness, treatment, and control (ATC) among adults in the country. In this study, we estimate the prevalence and ATC of diabetes among adults across various sociodemographic groups and states of India. We used data on 2,078,315 individuals aged 15 years and over from the recent fifth round, the most recent one, of the National Family Health Survey (NFHS-5), 2019-2021, that was carried out across all the states of India. Diabetic individuals were identified as those who had random blood glucose above 140 mg/dL or were taking diabetes medication or has doctor-diagnosed diabetes. Diabetic individuals who reported diagnosis were labelled as aware, those who reported taking medication for controlling blood glucose levels were labelled as treated and those whose blood glucose levels were < 140 mg/dL were labelled as controlled. The estimates of prevalence of diabetes, and ATC were age-sex adjusted and disaggregated by household wealth quintile, education, age, sex, urban-rural residence, caste, religion, marital status, household size, and state. Concentration index was used to quantify socioeconomic inequalities and multivariable logistic regression was used to estimate the adjusted differences in those outcomes. We estimated diabetes prevalence to be 16.1% (15.9-16.1%). Among those with diabetes, 27.5% (27.1-27.9%) were aware, 21.5% (21.1-21.7%) were taking treatment and 7% (6.8-7.1%) had their diabetes under control. Across the states of India, the adjusted rates of awareness varied from 14.4% (12.1-16.8%) to 54.4% (40.3-68.4%), of treatment from 9.3% (7.5-11.1%) to 41.2% (39.9-42.6%), and of control from 2.7% (1.6-3.7%) to 11.9% (9.7-14.0%). The age-sex adjusted rates were lower (p < 0.001) among the poorer and less educated individuals as well as among males, residents of rural areas, and those from the socially backward groups Among individuals with diabetes, the richest fifth were respectively 12.4 percentage points (pp) (11.3-13.4; p < 0.001), 10.5 pp (9.7-11.4; p < 0.001), and 2.3 pp (1.6-3.0; p < 0.001) more likely to be aware, getting treated, and having diabetes under control, than the poorest fifth. The concentration indices of ATC were 0.089 (0.085-0.092), 0.083 (0.079-0.085) and 0.017 (0.015-0.018) respectively. Overall, the ATC of diabetes is low in India. It is especially low the poorer and the less educated individuals. Targeted interventions and management can reduce the diabetes burden in India.

580. Taxonomic and enzymatic basis of the cellulolytic microbial consortium KKU-MC1 and its application in enhancing biomethane production.

Sci Rep

2023 Feb 20

Wongfaed N, O-Thong S, Sittijunda S

581. Bimodal CNN for cardiovascular disease classification by co-training ECG grayscale images and scalograms.

Sci Rep

2023 Feb 20

Yoon T, Kang D.

582. NLRC3 is a potential prognostic biomarker that is correlated with immune cell infiltration in lung adenocarcinoma.

Sci Rep

2023 Feb 20

Zhuo Y, Li X, Feng W.

583. Computational investigation of IP(3) diffusion.

Sci Rep

2023 Feb 20

Ornelas-Guevara R, Gil D, Voorsluijs V

584. A monocarboxylate transporter-dependent mechanism confers resistance to exercise-induced fatigue in a high-altitude hypoxic environment.

Sci Rep

2023 Feb 20

Gao C(#), Yang B(#), Li Y

585. SARS-CoV-2 alters neural synchronies in the brain with more severe effects in younger individuals.

Sci Rep

2023 Feb 20

Valsamis H, Baki SA, Leung J

586. Differences in skin test reactions to official and defined antigens in guinea pigs exposed to non-tuberculous and tuberculous bacteria.

Sci Rep

2023 Feb 20

Fernández-Veiga L, Fuertes M, Geijo MV

587. Entanglement transmission due to the Dzyaloshinskii-Moriya interaction.

Sci Rep

2023 Feb 20

Motamedifar M, Sadeghi F, Golshani M.

588. A spectroscopic and quantum chemical calculation method for the characterisation of metal ions complexed with propyl gallate and procyanidins.

Sci Rep

2023 Feb 20

Zhang L, Guan Q, Zhang H

589. Taguchi optimization and modelling of stir casting process parameters on the percentage elongation of aluminium, pumice and carbonated coal composite.

Sci Rep

2023 Feb 20

Ibrahim TK, Yawas DS, Dan-Asabe B

590. Insect recognition based on complementary features from multiple views.

Sci Rep

2023 Feb 20

An J(#), Du Y(#), Hong P

591. Combating errors in quantum communication: an integrated approach.

Sci Rep

2023 Feb 20

Bala R, Asthana S, Ravishankar V.

592. Elucidation of the (R)-enantiospecific benzylisoquinoline alkaloid biosynthetic pathways in sacred lotus (Nelumbo nucifera).

Sci Rep

2023 Feb 20

Menéndez-Perdomo IM, Facchini PJ.

593. Risk factors for stroke among anthropometric indices and lipid profiles in the Korean population: a large-scale cross-sectional study.

Sci Rep

2023 Feb 20

Yim MH, Jeon YJ, Lee BJ.

Stroke is strongly associated with death and disability. However, the associations between stroke and lipid profiles such as total cholesterol, triglycerides, high-density lipoprotein cholesterol (HDL-C), and red blood cells (RBCs) and anthropometric indices such as waist circumference and waist-to-height ratio (WHtR) remain unclear. The objective of this study was to investigate these relationships in a Korean population. This large-scale cross-sectional study included data from 38,190 subjects collected from 2010 to 2018 by the Korea National Health and Nutrition Examination Survey (KNHANES). Simple logistic regression models and multiple logistic regression models were used to evaluate the association of stroke with lipid profiles and anthropometric indices in the crude model, adjusted Model 1, and fully adjusted Model 2. In men, stroke was negatively associated with height, weight, and hematocrit level. Total cholesterol and triglycerides were strongly negatively associated with stroke in Model 2. Creatinine level and stroke were weakly associated. Additionally, height, weight, total cholesterol, triglycerides, and hematocrit and creatinine levels were associated with stroke both before and after adjustment. In women, in Model 2, stroke was positively associated with height, weight, and creatinine level. A strong negative association was found between total cholesterol and stroke. Stroke was negatively associated with hemoglobin level, hematocrit level, and RBCs. Additionally, total cholesterol, hemoglobin level, hematocrit level, creatinine level, and RBCs were associated with stroke both before and after adjustment. Weight and height were more closely associated with stroke than waist circumference and WHtR in Korean men. Our results suggested that the association of stroke with triglycerides, height, and weight differed according to sex and that HDL-C was not associated with stroke in people of either sex.

594. Impact of time to full enteral feeding on long-term neurodevelopment without mediating by postnatal growth failure in very-low-birth-weight-infants.

Sci Rep

2023 Feb 20

Yoon SA(#), Lee MH(#), Chang YS.

595. Designing plant-transparent agrivoltaics.

Sci Rep

2023 Feb 2

Stallknecht EJ(#), Herrera CK(#), Yang C

596. Short-term sedimentation dynamics in mesotidal marshes.

Sci Rep

2023 Feb 2

Carrasco AR, Kombiadou K, Matias A.

597. Carbon black-containing self-healing adhesive hydrogels for endoscopic tattooing.

Sci Rep

2023 Feb 2

Kwon HJ(#), Shin HH(#), Hyun DH

598. Matrix-entrapped fibers create ecological niches for gut bacterial growth.

Sci Rep

2023 Feb 2

Bulut N, Cantu-Jungles TM, Zhang X

599. Effects of wounds in the cell membrane on cell division.

Sci Rep

2023 Feb 2

Tanvir MIO, Yumura S.

600. Maternal immune activation affects socio-communicative behavior in adult rats.

Sci Rep

2023 Feb 2

Gzieło K, Piotrowska D, Litwa E

601. Relationship between brain metastasis and thyroid transcription factor 1.

Sci Rep

2023 Feb 2

Kut E, Menekşe S.

602. Language combinations of multilinguals are reflected in their first-language knowledge and processing.

Sci Rep

2023 Feb 2

Kepinska O, Caballero J, Oliver M

603. Efficacy and aesthetic outcomes for quilting sutures in the prevention of seroma after mastectomy.

Sci Rep

2023 Feb 2

Foulon A, Mancaux A, Theret P

604. The less obvious effect of hosting the Olympics on sporting performance.

Sci Rep

2023 Feb 2

Csurilla G, Fertő I.

605. Characteristic cortico-cortical connection profile of human precuneus revealed by probabilistic tractography.

Sci Rep

2023 Feb 2

Jitsuishi T, Yamaguchi A.

606. Distributed compact plasma reactor decontamination for planetary protection in space missions.

Sci Rep

2023 Feb 2

Choudhury B, Revazishvili T, Lozada M

607. Comparing event-related potentials of retrospective and prospective metacognitive judgments during episodic and semantic memory.

Sci Rep

2023 Feb 2

Irak M, Soylu C, Yavuz M.

608. Longitudinal profiles of the fecal metabolome during the first 2 years of life.

Sci Rep

2023 Feb 2

Holzhausen EA, Shen N, Chalifour B

609. Fetal bovine serum, an important factor affecting the reproducibility of cell experiments.

Sci Rep

2023 Feb 2

Liu S(#), Yang W(#), Li Y

610. Severe SARS-Cov2 pneumonia in vaccinated patients: a multicenter cohort study.

Sci Rep

2023 Feb 2

Mirouse A(#), Friol A(#), Moreau AS

Vaccination reduces risk of infection, hospitalization, and death due to SARS-Cov2. Vaccinated patients may however experience severe SARS-Cov2 disease. The objective was to describe clinical features of vaccinated patients requiring intensive care unit (ICU) admission due to SARS-Cov2 infection and compare them to a published cohort of unvaccinated patients. We performed a multicenter cohort study of patients with severe SARS-Cov2 disease admitted to 15 ICUs in France between January and September 2021. 100 consecutive vaccinated patients (68 (68%) men, median age 64 [57-71]) were included. Immunosuppression was reported in 38 (38%) patients. Among available serologies at ICU admission, 64% exhibited an optimal antibody level. Median SOFA score at ICU admission was 4 [4-6.3] and median PaO2/FiO2 ratio was 84 [69-128] mmHg. A total of 79 (79%) and 18 (18%) patients received high flow nasal oxygen and non-invasive mechanical ventilation, respectively. Invasive mechanical ventilation (IMV) was initiated in 48 (48%) with a median duration of 11 [5-19] days. During a median ICU length-of-stay of 8 [4-20] days, 31 (31%) patients died. Age (OR per 5-years increment 1.38 CI95% [1.02-1.85], p = 0.035), and SOFA at ICU admission (OR 1.40 CI95% [1.14-1.72] per point, p = 0.002) were independently associated with mortality. When compared to a cohort of 1316 unvaccinated patients (72% men, median age 63 [53-71]), vaccinated patients exhibited less frequently diabetes (16 [16%] vs. 351 [27%], p = 0.029) but were more frequently immunosuppressed (38 [38%] vs. 109 (8.3%), p < 0.0001), had more frequently chronic kidney disease (24 [24%] vs. 89 (6.8%), p < 0.0001), chronic heart failure (16 [16%] vs. 58 [4.4%], p < 0.0001), and chronic liver disease (3 [3%] vs. 8 [0.6%], p = 0.037) compared to unvaccinated patients. Despite similar severity, vaccinated patients required less frequently IMV at ICU day 1 and during ICU stay (23 [23%] vs. 785 [59.7%], p < 0.0001, and 48 [48%] vs. 930 [70.7%], p < 0.0001, respectively). There was no difference concerning ICU mortality (31 [31%] vs. 379 [28.8%], p = 0.64). Severe SARS-Cov2 infection after vaccination occurs mainly in patients with immunosuppression, chronic kidney, heart or liver failure. Age and disease severity are independently associated with mortality.

611. Multimodal single-cell analyses of peripheral blood mononuclear cells of COVID-19 patients in Japan.

Sci Rep

2023 Feb 2

Kashima Y, Mizutani T, Nakayama-Hosoya K

612. An open source Python library for environmental isotopic modelling.

Sci Rep

2023 Feb 2

Hassanzadeh A, Valdivielso S, Vázquez-Suñé E

613. Experiencing sweet taste is associated with an increase in prosocial behavior.

Sci Rep

2023 Feb 2

Schaefer M, Kühnel A, Schweitzer F

614. Subduction thermal regime, petrological metamorphism and seismicity under the Mariana arc.

Sci Rep

2023 Feb 2

Qu R, Zhu W, Ji Y

615. Environmental factors driving the abundance of Philaenus spumarius in mesomediterranean habitats of Corsica (France).

Sci Rep

2023 Feb 2

Chartois M, Mesmin X, Quiquerez I

616. The ferroptosis signature predicts the prognosis and immune microenvironment of nasopharyngeal carcinoma.

Sci Rep

2023 Feb 2

Zhou J, Guo T, Zhou L

617. Social isolation in patients with chronic limb-threatening ischemia: a cross-sectional study.

Sci Rep

2023 Feb 2

Takahara M, Iida O, Ohura N

Assistance by family members or friends plays important roles in the course of treating patients with chronic limb-threatening ischemia (CLTI), both during hospitalization and after discharge. The aim of this study was to reveal the prevalence of social isolation and to explore relevant clinical backgrounds in patients with CLTI presenting with tissue loss and requiring revascularization. We analyzed 413 patients registered in a multicenter study in whom revascularization were scheduled for CLTI with tissue loss. Social isolation was analyzed by assessing the residence status of the patients and the involvement of a trusted family member or friend in their daily lives and during hospitalization. Patients living alone accounted for 24.5% (95% confidence interval [CI] 20.1-28.8%) of the study population. Patients receiving welfare were more likely to live alone (P < 0.001). For patients living alone, 21.8% (95% CI 12.8-30.8%) met a trusted family member or friend in their daily lives less than once per year. Younger age and receiving welfare were independently associated with lower frequency of meeting the trusted person in their daily lives (both P < 0.05). The adjusted odds ratio of age and receiving welfare was 0.44 (95% CI 0.29-0.67) per 10-year increase and 3.47 (95% CI 1.43-8.44), respectively. During hospitalization, 9.9% (95% CI 6.8-13.0%) of the patients had no hospital visits by a trusted family member or friend on three key occasions: the patient's first hospital visit, the preoperative explanation regarding the planned operation, and the day of the operation. Younger age and receiving welfare were independently associated with lower frequency of hospital visits by a family member or friend (both P < 0.05). The adjusted odds ratio of age and receiving welfare for no visit versus ≥ 1 visit was 0.51 (0.36-0.74) per 10-year increase and 5.29 (2.46-11.4), respectively. In conclusion, social isolation is common among patients with CLTI, especially younger patients and those on welfare. Practical countermeasures against social isolation are warranted in the management of CLTI.

618. Novel green flexible rice straw nanofibers/zinc oxide nanoparticles films with electrical properties.

Sci Rep

2023 Feb 2

El-Wahab RMA, Fadel SM, Abdel-Karim AM

619. Quantitative monitoring and modelling of retrodialysis drug delivery in a brain phantom.

Sci Rep

2023 Feb 2

Rognin E, Willis-Fox N, Daly R.

620. Effects of time-restricted feeding on letrozole-induced mouse model of polycystic ovary syndrome.

Sci Rep

2023 Feb 2

Ryu KJ, Park H, Han YI

621. Circulating microRNA expression signatures accurately discriminate myalgic encephalomyelitis from fibromyalgia and comorbid conditions.

Sci Rep

2023 Feb 2

Nepotchatykh E, Caraus I, Elremaly W

622. Safe reinforcement learning under temporal logic with reward design and quantum action selection.

Sci Rep

2023 Feb 2

Cai M, Xiao S, Li J

623. The human microbial exposome: expanding the Exposome-Explorer database with gut microbial metabolites.

Sci Rep

2023 Feb 2

Neveu V(#), Nicolas G(#), Amara A

Metabolites produced by the gut microbiota play an important role in the cross-talk with the human host. Many microbial metabolites are biologically active and can pass the gut barrier and make it into the systemic circulation, where they form the gut microbial exposome, i.e. the totality of gut microbial metabolites in body fluids or tissues of the host. A major difficulty faced when studying the microbial exposome and its role in health and diseases is to differentiate metabolites solely or partially derived from microbial metabolism from those produced by the host or coming from the diet. Our objective was to collect data from the scientific literature and build a database on gut microbial metabolites and on evidence of their microbial origin. Three types of evidence on the microbial origin of the gut microbial exposome were defined: (1) metabolites are produced in vitro by human faecal bacteria; (2) metabolites show reduced concentrations in humans or experimental animals upon treatment with antibiotics; (3) metabolites show reduced concentrations in germ-free animals when compared with conventional animals. Data was manually collected from peer-reviewed publications and inserted in the Exposome-Explorer database. Furthermore, to explore the chemical space of the microbial exposome and predict metabolites uniquely formed by the microbiota, genome-scale metabolic models (GSMMs) of gut bacterial strains and humans were compared. A total of 1848 records on one or more types of evidence on the gut microbial origin of 457 metabolites was collected in Exposome-Explorer. Data on their known precursors and concentrations in human blood, urine and faeces was also collected. About 66% of the predicted gut microbial metabolites (n = 1543) were found to be unique microbial metabolites not found in the human GSMM, neither in the list of 457 metabolites curated in Exposome-Explorer, and can be targets for new experimental studies. This new data on the gut microbial exposome, freely available in Exposome-Explorer ( http://exposome-explorer.iarc.fr/ ), will help researchers to identify poorly studied microbial metabolites to be considered in future studies on the gut microbiota, and study their functionalities and role in health and diseases.

624. Pien Tze Huang regulates phosphorylation of metabolic enzymes in mice of hepatocellular carcinoma.

Sci Rep

2023 Feb 2

Lin J, Wang S, Lan W

The Chinese medicine formula Pien Tze Huang (PZH) has been applied to the treatment of various diseases, the reported anti-tumor mechanisms included regulation of inflammation-associated cytokine secretion and cancer growth pathways. However, the potential influence of PZH on tumor metabolism remains unclear. This study aimed to investigate the global effect of PZH on hepatocellular carcinoma (HCC) compared with the anti-tumor agent sorafenib based on tandem mass tag (TMT) label proteomic and phosphoproteomic analysis in addition to parallel reaction monitoring (PRM) verification. It was observed that PZH could inhibit tumor weight by 59-69% in different concentrations. TMT proteomic studies indicated that fructose/mannose metabolism and glucagon signaling pathway in PZH group, and arachidonic acid metabolism and PPAR signaling pathway in sorafenib group, were significantly enriched, while glycolysis/gluconeogenesis pathway was found to be enriched remarkably both in PZH and sorafenib groups in TMT phosphoproteomic study. PRM verification further indicated that both PZH and sorafenib could down-regulate phosphorylations of the glycolytic enzymes phosphofructokinases 1, fructose-bisphosphate Aldolase A, phosphoglycerate mutase 2 and lactate dehydrogenase A chain, while phosphorylations of long chain fatty acid CoA ligase in fatty acid activation and acetyl-coenzyme A synthetase in glycolysis were significantly inhibited by PZH and sorafenib, respectively. This study proposed that PZH shared a similar anti-tumor mechanism of metabolic regulation to sorafenib, but differed in the regulation of some metabolic nodes. This is the first time to uncover the relationship between the anti-tumor effect of PZH and metabolic related enzymes, which distinguished from the known mechanisms of PZH. These data provided the potential molecular basis for PZH acting as a therapeutic drug for HCC, and offered cues of manipulation on Warburg effect under the treatment of PZH.

625. Characterisation of a cyclic peptide that binds to the RAS binding domain of phosphoinositide 3-kinase p110α.

Sci Rep

2023 Feb 2

Ismail M, Martin SR, George R

626. Degradation of 1-alkyl-3-methylimidazolium tetrafluoroborate in an ultrasonic zero-valent zinc and activated carbon micro-electrolysis system.

Sci Rep

2023 Feb 2

Lyu P, Guo W, Qi H

627. MAPkinases regulate secondary metabolism, sexual development and light dependent cellulase regulation in Trichoderma reesei.

Sci Rep

2023 Feb 2

Schalamun M, Beier S, Hinterdobler W

628. Fully automated immunoassay for cholesterol uptake capacity to assess high-density lipoprotein function and cardiovascular disease risk.

Sci Rep

2023 Feb 2

Murakami K, Harada A, Toh R

629. Enrichr in silico analysis of MS-based extracted candidate proteomic biomarkers highlights pathogenic pathways in systemic sclerosis.

Sci Rep

2023 Feb 2

Chairta PP, Nicolaou P, Christodoulou K.

630. FMRP, FXR1 protein and Dlg4 mRNA, which are associated with fragile X syndrome, are involved in the ubiquitin-proteasome system.

Sci Rep

2023 Feb 2

Shimizu H, Hohjoh H.

631. Low thigh muscle strength in relation to myosteatosis in patients with type 2 diabetes mellitus.

Sci Rep

2023 Feb 2

Huang Y(#), Yan J(#), Zhu H

632. Adverse events are not increased by controlled delay in surgery of acute upper extremity fractures.

Sci Rep

2023 Feb 2

Matias T, Axel S, Hannu K

633. Extra-viral DNA in adeno-associated viral vector preparations induces TLR9-dependent innate immune responses in human plasmacytoid dendritic cells.

Sci Rep

2023 Feb 2

Bucher K(#), Rodríguez-Bocanegra E(#), Wissinger B

634. Changes in pupil dilation and P300 amplitude indicate the possible involvement of the locus coeruleus-norepinephrine (LC-NE) system in psychological flow.

Sci Rep

2023 Feb 2

Lu H, van der Linden D, Bakker AB.

635. A mechanistic understanding of the effects of polyethylene terephthalate nanoplastics in the zebrafish (Danio rerio) embryo.

Sci Rep

2023 Feb 2

Bashirova N, Poppitz D, Klüver N

636. Different functional networks underlying human walking with pulling force fields acting in forward or backward directions.

Sci Rep

2023 Feb 2

Ogawa T, Obata H, Yokoyama H

637. Objective analysis of facial bone fracture CT images using curvature measurement in a surface mesh model.

Sci Rep

2023 Feb 2

Kim J, Seo C, Yoo JH

638. Dose rate effect on mortality from ischemic heart disease in the cohort of Russian Mayak Production Association workers.

Sci Rep

2023 Feb 2

Azizova TV, Grigoryeva ES, Hamada N.

639. Robust, practical and comprehensive analysis of soft compression image coding algorithms for big data.

Sci Rep

2023 Feb 2

Xin G, Fan P.

640. Molecular evolutionary insight of structural zinc atom in yeast xylitol dehydrogenases and its application in bioethanol production by lignocellulosic biomass.

Sci Rep

2023 Feb 2

Yoshiwara K(#), Watanabe S(#), Watanabe Y.

641. Association of combustible cigarettes and heated tobacco products use with SARS-CoV-2 infection and severe COVID-19 in Japan: a JASTIS 2022 cross-sectional study.

Sci Rep

2023 Feb 2

Nishimura M, Asai K, Tabuchi T

642. CT-based data generation for foreign object detection on a single X-ray projection.

Sci Rep

2023 Feb 2

Andriiashen V, van Liere R, van Leeuwen T

643. Analysis of Himalayan marmot distribution and plague risk in Qinghai province of China using the "3S" technology.

Sci Rep

2023 Feb 2

Wu H(#), Wu H(#), Wang Y

To provide guidance for plague surveillance and a reliable basis for plague prevention and control, we analyzed the habitat characteristics of Himalayan marmots, developed Himalayan marmot information collection system V3.0 based on global navigation satellite system (GNSS), remote sensing, and geographic information system ("3S") technology, and drew a predictive spatial distribution map of Himalayan marmots in Qinghai Province. Field survey data of 352 marmot plague sites in Qinghai Province were collected in 2014, and the data from 80 sample sites were included. The Himalayan marmot habitat characteristics were analyzed based on "3S" technology using five environment variables (elevation, slope, aspect, vegetation cover, and grass type) and the geographical coordinates. Himalayan marmot information collection system V3.0, which has been approved by the National Copyright Administration of the People's Republic of China (No.00764743), was used to draw a predictive spatial distribution map of Himalayan marmots in Qinghai province. Moreover, from 2015 to 2017, positioning data of the plague-foci and plague-free areas in Qinghai Province were collected using GNSS receptor for field validations to verify the accuracy of the marmot predictive spatial distribution map. Elevation, slope, vegetation cover, and grassland type were identified as important environmental factors that determine the spatial distribution of Himalayan marmots. The suitable range of environmental features was 3400-4600 m elevation, 5°-20° slope, 0.60-1.00 vegetation cover, and alpine meadows. The Himalayan marmot predictive spatial distribution map in Qinghai Province based on "3S" technology and marmot information collection system V3.0 had a spatial resolution of 30 m. Field validation in areas of Qinghai Province revealed a prediction accuracy and mean absolute error of 0.8669 and 0.1331, respectively, which indicated excellent prediction accuracy. This study greatly improved the work efficiency of plague surveillance and effectively reduced the work intensity of researchers. Application of "3S" technology and marmot information collection system V3.0 has improved the data collection efficiency, provided new technical means for plague investigation and research, and provided a reference for development of plague surveillance programs. The research results will play a positive role in promoting the improvement and perfection of plague prevention and control strategies in Qinghai province and even in China.

644. Simultaneous activation of CXC chemokine receptor 4 and histamine receptor H1 enhances calcium signaling and cancer cell migration.

Sci Rep

2023 Feb 2

Park C, Lee JW, Kim K

645. Study on the spatialization of anthropogenic carbon emissions in China based on SVR-ZSSR.

Sci Rep

2023 Feb 2

Liu M, Qi L, Chen H

646. Reynolds nano fluid model for Casson fluid flow conveying exponential nanoparticles through a slandering sheet.

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2023 Feb 2

Nadeem S, Ishtiaq B, Ben Hamida MB

647. Risk of dementia and mild cognitive impairment in older adults with a criminal background: a population-based register study in Sweden.

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2023 Feb 2

Solares C, Garcia-Argibay M, Chang Z

648. Long-term survival and second malignant tumor prediction in pediatric, adolescent, and young adult cancer survivors using Random Survival Forests: a SEER analysis.

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2023 Feb 2

Zhang IY, Hart GR, Qin B

649. New Dielis species and structural dichotomy of the mitochondrial cox2 gene in Scoliidae wasps.

Sci Rep

2023 Feb 2

Szafranski P.

650. Comparative efficacy of onsite, digital, and other settings for cognitive behavioral therapy for insomnia: a systematic review and network meta-analysis.

Sci Rep

2023 Feb 2

Simon L, Steinmetz L, Feige B

651. Determination of the characteristic curves of a nonlinear first order system from Fourier analysis.

Sci Rep

2023 Feb 2

Gonzalez FJ.

Based on Fourier analysis, we develop an expression for modeling and simulating nonlinear first order systems. This expression is associated to a nonlinear first order differential equation [Formula: see text], where [Formula: see text] is the dynamical variable, [Formula: see text] is the driving force, and the f and g functions are the characteristic curves which are associated to dissipative and memory elements, respectively. The model is obtained from the sinusoidal response, specifically by calculating the Fourier analysis of y(t) for [Formula: see text], where the model parameters are the Fourier coefficients of the response, and the values of [Formula: see text], [Formula: see text] and [Formula: see text]. The same expression is used for two kinds of time-domain simulations: to calculate other driving force [Formula: see text] based on a dynamical variable [Formula: see text]; and, to calculate the dynamical variable [Formula: see text] based on a driving force [Formula: see text]. In both cases, the dynamical variable must remain in the range [Formula: see text]. By analyzing this expression, we found an equivalence between the Fourier coefficients and the polynomial regressions of the characteristic curves of f and g. This result allows us to obtain the system modeling and simulation based on the amplitude and phase Fourier spectrum obtained from the Fast Fourier Transform (FFT) of the sampled [Formula: see text] version of y(t). It is shown that this technique has a low computational complexity, and it is expected to be suitable for real-time applications for system modeling, simulation and control, in particular when the explicit expressions of the characteristic curves are unknown. Fourier analysis is a fundamental tool in electronics, mathematics and physics, but to the best of the author's knowledge, no work has found this clear evidence of the connection between the Fourier analysis and a first order differential equation. The aim of this work is to initiate a systematic study on this topic.

652. Tuning the fluorescence of Dy(3+) via the structure of borophosphate glasses.

Sci Rep

2023 Feb 2

Griebenow K, Truong MP, Munoz F

653. Large-scale geological structures of the Egyptian Nubian Shield.

Sci Rep

2023 Feb 2

Hamimi Z, Eldosouky AM, Hagag W

654. Trapping and manipulating skyrmions in two-dimensional films by surface acoustic waves.

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2023 Feb 2

Miyazaki Y, Yokouchi T, Shiomi Y.

655. Heterogeneity of interaction strengths and its consequences on ecological systems.

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2023 Feb 2

Jackson Z, Xue B.

656. Atomistic-geometric simulations to investigate the mechanical stability of monocrystalline sI methane hydrates under pressure.

Sci Rep

2023 Feb 2

Zhu X, Guerra A, Servio P

657. Design, development and application of a compact robotic transplanter with automatic seedling picking mechanism for plug-type seedlings.

Sci Rep

2023 Feb 2

Khadatkar A, Pandirwar AP, Paradkar V.

658. Dynamical behaviors, circuit design, and synchronization of a novel symmetric chaotic system with coexisting attractors.

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2023 Feb 2

Qiu H, Xu X, Jiang Z

659. Understanding the role of natural and anthropogenic forcings in structuring the periphytic algal assemblages in a regulated river ecosystem.

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2023 Feb 2

Sofi MS, Hamid A, Bhat SU

660. Stem stiffness functionality in a submerged canopy patch under oscillatory flow.

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2023 Feb 2

Barcelona A, Colomer J, Serra T.

661. A secure and dependable trust assessment (SDTS) scheme for industrial communication networks.

Sci Rep

2023 Feb 2

Khan T, Singh K, Ahmad K

662. Leveraging space-time modulation for energy coupling control in electromagnetic coupled transmission lines structures.

Sci Rep

2023 Feb 2

Baharian M, Rashed Mohassel JA.

663. Sustainable synthesis of graphene sand composite from waste cooking oil for dye removal.

Sci Rep

2023 Feb 2

Abdullah Sani NS, Ang WL, Mohammad AW

664. Soil consolidation acoustic experiment and pore pressure prediction model establishment-taking the Yingqiong Basin as an example.

Sci Rep

2023 Feb 2

Han Z, Sun B, Cheng Y

665. Contrasting patterns of population structure of Bulwer's petrel (Bulweria bulwerii) between oceans revealed by statistical phylogeography.

Sci Rep

2023 Feb 2

Silva MC, Catry P, Bried J

666. Novel versatile topologies and design optimization of wide-bandstop frequency selective surfaces for X-band, Ku-band and millimeter-wave applications.

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2023 Feb 2

Aziz RS, Koziel S(#), Leifsson L(#)

667. Development and validation of a robot social presence measurement dimension scale.

Sci Rep

2023 Feb 19

Chen N, Liu X, Zhai Y

668. Effect of total knee replacement on skeletal muscle mass measurements using dual energy X-ray absorptiometry.

Sci Rep

2023 Feb 19

Jang JY, Kim M(#), Lee D

669. Salinity stress improves antioxidant potential by modulating physio-biochemical responses in Moringa oleifera Lam.

Sci Rep

2023 Feb 18

Azeem M, Pirjan K, Qasim M

Moringa oleifera Lam. is a common edible plant, famous for several nutritional and therapeutic benefits. This study investigates the salt -induced modulations in plant growth, physio-biochemical responses, and antioxidant performance of M. oleifera grown under 0, 50, and 100 mM NaCl concentrations. Results showed that the plant effectively managed moderate salinity (50 mM NaCl) by maintaining succulence, weight ratios, and biomass allocation patterns of both shoot and root with minimal reduction in dry biomass. However, high salinity (100 mM NaCl) remarkably declined all growth parameters. The plant accumulated more Na+ and Cl-, while less K+ under salinity as compared to the control. Consequently, osmotic potentials of both root and leaf decreased under salinity, which was corroborated by the high amount of proline and soluble sugars. Increased level of H2O2 with significantly unchanged membrane fluidity indicating its role in perceiving and managing stress at moderate salinity. In addition, increased activities of superoxide dismutase, and catalase, with increased glutathione and flavonoid contents suggest an integrated participation of both enzymatic and non-enzymatic antioxidant components in regulating ROS. On the other hand, high salinity caused an outburst of ROS indicated by high H2O2, MDA, and electrolyte leakage. As a response, moringa drastically increased the activities of all antioxidant enzymes and contents of antioxidant molecules including ascorbic acid, glutathione, total phenols, and flavonoids with high radical scavenging and reducing power capacities. However, a considerable amount of energy was used in such management resulting in a significant growth reduction at 100 mM NaCl. This study suggests that moringa effectively resisted moderate salinity by modulating physio-biochemical attributes and effectively managing ion toxicity and oxidative stress. Salt stress also enhanced the medicinal potentials of moringa by increasing the contents of antioxidant compounds including ascorbic acid, glutathione, total phenols, and flavonoids and their resulting activities. It can be grown on degraded/ saline lands and biomass of this plant can be used for edible and medicinal purposes, besides providing other benefits in a global climate change scenario.

670. Rice-memolin, a novel peptide derived from rice bran, improves cognitive function after oral administration in mice.

Sci Rep

2023 Feb 18

Shobako M, Shobako N, Zhang B

Many people eat polished rice, while rice bran, a by-product known to be rich in protein and expected to have potential functions for health benefits, has not been effectively utilized. In this study, we determined that orally administered Val-Tyr-Thr-Pro-Gly (VYTPG) derived from rice bran protein improved cognitive decline in mice fed a high-fat diet (HFD). It was demonstrated that VYTPG was released from model peptides corresponding to fragment sequences of original rice proteins (Os01g0941500, Os01g0872700, and allergenic protein) after treatment with thermolysin, a microorganism-derived enzyme often used in industrial scale processes. The thermolysin digest also improved cognitive decline after oral administration in mice. Because VYTPG (1.0 mg/kg) potently improved cognitive decline and is enzymatically produced from the rice bran, we named it rice-memolin. Next, we investigated the mechanisms underlying the cognitive decline improvement associated with rice-memolin. Methyllycaconitine, an antagonist for α7 nicotinic acetylcholine receptor, suppressed the rice-memolin-induced effect, suggesting that rice-memolin improved cognitive decline coupled to the acetylcholine system. Rice-memolin increased the number of 5-bromo-2'-deoxyuridine (BrdU)-positive cells and promoted the mRNA expression of EGF and FGF-2 in the hippocampus, implying that these neurotropic factors play a role in hippocampal neurogenesis after rice-memolin administration. Epidemiologic studies demonstrated that diabetes is a risk factor for dementia; therefore, we also examined the effect of rice-memolin on glucose metabolism. Rice-memolin improved glucose intolerance. In conclusion, we identified a novel rice-derived peptide that can improve cognitive decline. The mechanisms are associated with acetylcholine and hippocampal neurogenesis. Rice-memolin is the first rice-brain-derived peptide able to improve cognitive decline.

671. Low-cost fully additively manufactured passive microwave components exploiting available 3D flexibility.

Sci Rep

2023 Feb 18

Piekarz I, Wincza K, Gruszczynski S

672. Wavelets based physics informed neural networks to solve non-linear differential equations.

Sci Rep

2023 Feb 18

Uddin Z, Ganga S, Asthana R

673. Reevaluating the wave power-salt marsh retreat relationship.

Sci Rep

2023 Feb 18

Houttuijn Bloemendaal LJ, FitzGerald DM, Hughes ZJ

674. The tight junction protein occludin modulates blood-brain barrier integrity and neurological function after ischemic stroke in mice.

Sci Rep

2023 Feb 18

Sugiyama S, Sasaki T, Tanaka H

675. Peak knee joint moments accurately predict medial and lateral knee contact forces in patients with valgus malalignment.

Sci Rep

2023 Feb 18

Holder J, van Drongelen S, Uhlrich SD

676. Mapping localization of 21 endogenous proteins in the Golgi apparatus of rodent neurons.

Sci Rep

2023 Feb 18

van Bommel DM, Toonen RF, Verhage M.

677. Urokinase-type plasminogen activator blockade ameliorates experimental colitis in mice.

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2023 Feb 18

Kida Y, Okahisa T, Sato Y

678. Prediction of stable radon fluoride molecules and geometry optimization using first-principles calculations.

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2023 Feb 18

Kang J, Park I, Shim JH

679. Portable and cost-effective genetic detection and characterization of Plasmodium falciparum hrp2 using the MinION sequencer.

Sci Rep

2023 Feb 18

Sabin S, Jones S, Patel D

680. Design and implementation of elliptical mantle cloaks for polarization decoupling of two tightly spaced interleaved co-frequency patch array antennas.

Sci Rep

2023 Feb 18

Masoumi R, Kazemi R, Fathy AE.

681. Phase-change materials based on amorphous equichalcogenides.

Sci Rep

2023 Feb 18

Golovchak R, Plummer J, Kovalskiy A

682. Dissipative MHD free convective nanofluid flow past a vertical cone under radiative chemical reaction with mass flux.

Sci Rep

2023 Feb 18

Ragulkumar E, Palani G, Sambath P

Recently, Nanoparticles have supplied diverse challenges to several scientific issues. Nanoparticles dispersed in a variety of conventional fluids can change the flow and heat transmission properties of the fluids. The mathematical technique is used in this work to investigate the MHD water-based nanofluid flow via an upright cone. The heat and mass flux pattern is used in this mathematical model to examine MHD, viscous dissipation, radiation, chemical reactions and suction/injection processes. The finite difference approach was used to find the solution to the basic governing equations. A combination of nanofluids comprising nanoparticles including aluminum oxide (Al[Formula: see text]O[Formula: see text]), silver (Ag), copper (Cu) and titanium dioxide (TiO[Formula: see text]) with a volume fraction of nanoparticles (0, 0.01, 0.02, 0.03, 0.04), viscous dissipation ([Formula: see text]), MHD (M = 0.5, 1.0), radiation (Rd = 0.4, 1.0, 2.0), chemical reaction ([Formula: see text]) and heat source/sink ([Formula: see text]) . The mathematical findings of velocity, temperature, concentration, skin friction, heat transfer rate as well as Sherwood number distributions are analyzed diagrammatically using non-dimensional flow parameters. It has been discovered that by increasing the value of the radiation parameter, velocity and temperature profiles enhance. The production of safe, high-quality products for consumers across the world depends on vertical cone mixers, from food to medicine, household cleansers to personal hygiene products. Every vertical cone mixer type we provide was especially developed to meet the demands of industry. As the mixer warms up on the slanted surface of the cone while vertical cone mixers are being utilized, the effectiveness of the grinding may be felt. The temperature is transferred along the cone's slant surface as a consequence of the mixture being mixed quickly and repeatedly. This study describes the heat transmission in these events and their parametric properties. The heated cone's temperature is then convective to its surroundings.

683. First principles and mean field study on the magnetocaloric effect of YFe(3) and HoFe(3) compounds.

Sci Rep

2023 Feb 18

Abu-Elmagd MSM, Hammad T, Abdel-Kader A

684. Neuroplasticity enables bio-cultural feedback in Paleolithic stone-tool making.

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2023 Feb 18

Hecht EE, Pargeter J, Khreisheh N

685. Exploring the mechanism of anti-fatigue of resveratrol based on network pharmacology and molecular docking, and in vitro studies.

Sci Rep

2023 Feb 18

Ma P, Li J, Huang Q

686. The importance of temporal-fine structure to perceive time-compressed speech with and without the restoration of the syllabic rhythm.

Sci Rep

2023 Feb 18

Gransier R, Peeters S, Wouters J.

687. Quantum algorithms for geologic fracture networks.

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2023 Feb 18

Henderson JM, Podzorova M, Cerezo M

688. circRNA-ZCCHC14 affects the chondrogenic differentiation ability of peripheral blood-derived mesenchymal stem cells by regulating GREM1 through miR-181a.

Sci Rep

2023 Feb 18

Zhao D, Chen H, Zhong J

689. Comparison of different software for processing physical activity measurements with accelerometry.

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2023 Feb 18

Verhoog S, Gubelmann C, Bano A

690. Higher throughput workflow with sensitive, reliable and automatic quantification of myelination in vitro suitable for drug screening.

Sci Rep

2023 Feb 18

Seiler S, Wälti CM, de Barros V

691. The optimization of postoperative radiotherapy in de novo stage IV breast cancer: evidence from real-world data to personalize treatment decisions.

Sci Rep

2023 Feb 18

Miyashita M, Balogun OB, Olopade OI

692. The effect of orthotics on plantar pressure in children with infantile tibia vara (Blount's disease).

Sci Rep

2023 Feb 18

Güven E, Çıtaker S, Alsancak S.

693. Ecological momentary assessment of mind-wandering: meta-analysis and systematic review.

Sci Rep

2023 Feb 18

Kawashima I, Hinuma T, Tanaka SC.

694. Amniotic membrane application in surgical treatment of conjunctival tumors.

Sci Rep

2023 Feb 17

Furdova A, Czanner G, Koller J

695. Chair squat performance as a potential predictor of nurses' physical capabilities in ergonomic patient transfers.

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2023 Feb 17

Brinkmann A, Kowalski C, Lau S

696. Machine learning intelligence to assess the shear capacity of corroded reinforced concrete beams.

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2023 Feb 17

Kumar A, Arora HC, Kapoor NR

The ability of machine learning (ML) techniques to forecast the shear strength of corroded reinforced concrete beams (CRCBs) is examined in the present study. These ML techniques include artificial neural networks (ANN), adaptive-neuro fuzzy inference systems (ANFIS), decision tree (DT) and extreme gradient boosting (XGBoost). A thorough databank with 140 data points about the shear capacity of CRCBs with various degrees of corrosion was compiled after a review of the literature. The inputs parameters of the implemented models are the width of the beam, the effective depth of the beam, concrete compressive strength (CS), yield strength of reinforcement, percentage of longitudinal reinforcement, percentage of transversal reinforcement (stirrups), yield strength of stirrups, stirrups spacing, shear span-to-depth ratio (a/d), corrosion degree of main reinforcement, and corrosion degree of stirrups. The coefficient of determination of the ANN, ANFIS, DT, and XGBoost models are 0.9811, 0.9866, 0.9799, and 0.9998, respectively. The MAPE of the XGBoost model is 99.39%, 99.16%, and 99.28% lower than ANN, ANFIS, and DT models. According to the results of the sensitivity examination, the shear strength of the CRCBs is most affected by the depth of the beam, stirrups spacing, and the a/d. The graphical displays of the Taylor graph, violin plot, and multi-histogram plot additionally support the XGBoost model's dependability and precision. In addition, this model demonstrated good experimental data fit when compared to other analytical and ML models. Accurate prediction of shear strength using the XGBoost approach confirmed that this approach is capable of handling a wide range of data and can be used as a model to predict shear strength with higher accuracy. The effectiveness of the developed XGBoost model is higher than the existing models in terms of precision, economic considerations, and safety, as indicated by the comparative study.

697. The association between muscle architecture and muscle spindle abundance.

Sci Rep

2023 Feb 17

Kissane RWP(#), Charles JP(#), Banks RW

698. Modulation of AMPK/ TET2/ 5-hmC axis in response to metabolic alterations as a novel pathway for obesity-related colorectal cancer development.

Sci Rep

2023 Feb 17

Kon T, Sasaki Y, Abe Y

699. Association between levels of exposure to heavy metals and renal function indicators of residents in environmentally vulnerable areas.

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2023 Feb 17

Kwon JY, Lee S, Surenbaatar U

700. Serum lactate monitoring may help to predict neurological function impairment caused by acute metabolism crisis.

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2023 Feb 17

Liu D, Yao Q, Song B

701. Neuroprotective and antioxidant properties of new quinolylnitrones in in vitro and in vivo cerebral ischemia models.

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2023 Feb 17

Chamorro B, Izquierdo-Bermejo S, Serrano J

Cerebral ischemia is a condition affecting an increasing number of people worldwide, and the main cause of disability. Current research focuses on the search for neuroprotective drugs for its treatment, based on the molecular targets involved in the ischemic cascade. Nitrones are potent antioxidant molecules that can reduce oxidative stress. Here we report the neuroprotective properties and the antioxidant power of the six new quinolylnitrones (QNs) 1-6 for their potential application in stroke therapy. QNs 1-4 are 2-chloro-8-hydroxy-substituted QNs bearing N-t-butyl or N-benzyl substituents at the nitrone motif located at C3, whereas QN5 and QN6 are 8-hydroxy QNs bearing N-t-butyl or N-benzyl substituents at the nitrone motif located at C2, respectively. In vitro neuroprotection studies using QNs 1-6 in an oxygen-glucose-deprivation model of cerebral ischemia, in human neuroblastoma cell cultures, indicate that all QNs have promising neuroprotective, anti-necrotic, anti-apoptotic, and anti-oxidant properties against experimental ischemia-reperfusion in neuronal cultures. QN6 stands out as the most balanced nitrone out of all tested QNs, as it strongly prevents decreased neuronal metabolic activity (EC50 = 3.97 ± 0.78 μM), as well as necrotic (EC50 = 3.79 ± 0.83 μM) and apoptotic cell death (EC50 = 3.99 ± 0.21 μM). QN6 showed high capacity to decrease superoxide production (EC50 = 3.94 ± 0.76 μM), similar to its parent molecule α-phenyl-tert-butyl nitrone (PBN) and the well-known anti-oxidant molecule N-acetyl-L-cysteine (NAC). Thus, QN6 demonstrated the highest antioxidant power out of the other tested QNs. Finally, in vivo treatment with QN6 in an experimental permanent stroke model elicited a significant reduction (75.21 ± 5.31%) of the volume size of brain lesion. Overall, QN6 is a potential agent for the therapy of cerebral ischemia that should be further investigated.

702. A new method for analyzing non-uniform guiding structures.

Sci Rep

2023 Feb 17

Yasi N, Boozari M, Alijani MGH

703. Phase-sensitive optical time domain reflectometry based on geometric phase measurement.

Sci Rep

2023 Feb 17

Shaheen S, Hicke K, Krebber K.

704. Ultrasound assessment of gastric contents and volume in patients undergoing endoscopic endonasal transsphenoidal surgery: a prospective observational study.

Sci Rep

2023 Feb 17

Jia H(#), He E(#), Gao S

705. Preclinical dental students self-assessment of an improved operative dentistry virtual reality simulator with haptic feedback.

Sci Rep

2023 Feb 17

Rodrigues P, Nicolau F(#), Norte M(#)

To test and evaluate the second installment of DENTIFY, a virtual reality haptic simulator for Operative Dentistry (OD), on preclinical dental students, by focusing on user performance and self-assessment. Twenty voluntary unpaid preclinical dental students, with different background experience, were enrolled for this study. After the completion of an informed consent, a demographic questionnaire, and being introduced to the prototype (on the first testing session), three testing sessions followed (S1, S2, S3). Each session involved the following steps: (I) free experimentation; (II) task execution; S3 also included (III) completion of questionnaires associated with the experiment (total of 8 Self-Assessment Questions (SAQ)); and (IV) guided interview. As expected, drill time decreased steadily for all tasks when increasing prototype use, verified by RM ANOVA. Regarding performance metrics (Comparisons by Student's t-test and ANOVA) recorded at S3, in overall, a higher performance was verified for participants with the following characteristics: female, non-gamer, no previous VR experience and with over 2 semesters of previous experience of working on phantom models. The correlation between the participants' performance (drill time), for the four tasks, and user self-assessment evaluation, verified by Spearman's rho analysis, allowed to conclude that a higher performance was observed in students who responded that DENTIFY improved their self perception of manual force applied. Regarding the questionnaires, Spearman's rho analysis showed a positive correlation between the improvement DENTIFY inputs on conventional teaching sensed by students, also enhancing their interest in learning OD, their desire to have more simulator hours and the improvement sensed on manual dexterity. All participating students adhered well to the DENTIFY experimentation. DENTIFY allows for student self-assessment and contributes to improving student performance. Simulators with VR and haptic pens for teaching in OD should be designed as a consistent and gradual teaching strategy, allowing multiplicity of simulated scenarios, bimanual manipulation, and the possibility of real-time feedback to allow for the student's immediate self-assessment. Additionally, they should create performance reports per student to ensure self-perception/criticism of their evolution over longer periods of learning time.

706. Transportation of dislocation plasticity in a dual-phase TiMo alloy.

Sci Rep

2023 Feb 17

Men J, Fu X, Yu Q.

707. Multi-objective integrated optimization study of prefabricated building projects introducing sustainable levels.

Sci Rep

2023 Feb 17

Peng J, Feng Y, Zhang Q(#)

708. Sensitivity and performance of three novel quantitative assays of SARS-CoV-2 nucleoprotein in blood.

Sci Rep

2023 Feb 17

Hillig T, Kristensen JR, Brasen CL

709. Machine learning to predict late respiratory support in preterm infants: a retrospective cohort study.

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2023 Feb 17

Wu TY, Lin WT, Chen YJ

710. Randomized multicenter trial to assess posterior capsule opacification and glistenings in two hydrophobic acrylic intraocular lenses.

Sci Rep

2023 Feb 17

Auffarth GU, Brézin A, Lignereux F

711. Transcriptomic profiling of programmed cell death 1 (PD-1) expressing T cells in early rheumatoid arthritis identifies a decreased CD4 + PD-1 + signature post-treatment.

Sci Rep

2023 Feb 17

Lowe K, Small A, Song Q

712. Anticancer properties of curcumin-treated Lactobacillus plantarum against the HT-29 colorectal adenocarcinoma cells.

Sci Rep

2023 Feb 17

Gholipour F, Amini M, Baradaran B

Probiotic bacteria with functions of importance to the health and well-being of the host exhibit various medicinal properties including anti-proliferative properties against cancer cells. There are observations demonstrating probiotic bacteria and their metabolomics can be different in various populations with different eating habits. Here, Lactobacillus plantarum was treated with curcumin (the major compound of turmeric), and its resistance to the curcumin was determined. After then the cell-free supernatants of untreated bacteria (CFS) and bacteria treated with curcumin (cur-CFS) were isolated and their anti-proliferative properties against HT-29 colon cancer cells were compared. The ability of L. plantarum treated with curcumin to combat a variety of pathogenic bacterial species and its ability to survive in acidic conditions were evidence that the probiotic properties of the bacterium were unaffected by the curcumin treatment. L. plantarum treated with curcumin and intact L. plantarum were both able to live in acidic conditions, according to the results of the resistance to low pH test. The MTT result showed that CFS and cur-CFS dose-dependently decreased the growth of HT29 cells with a half-maximal inhibitory concentration of 181.7 and 116.3 µL/mL at 48 h, respectively. Morphological alteration of DAPI-stained cells also exhibited significant fragmentation in the chromatin within the nucleus of cur-CFS-treated cells compared to CFS-treated HT29 cells. Moreover, flow cytometry analyses of apoptosis and cell cycle confirmed DAPI staining and MTT assay results and stipulated the increased occurrence of programmed cell death (apoptosis) in cur-CFS-treated cells (~ 57.65%) compared to CFS-treated cells (~ 47%). These results were more confirmed with qPCR and exhibited the upregulation of Caspase 9-3 and BAX genes, and downregulation of the BCL-2 gene in cur-CFS- and CFS-treated cells. In conclusion, turmeric spice and curcumin may affect the metabolomics of probiotics in intestinal flora which could subsequently influence their anticancer properties.

713. Hybrid feature engineering of medical data via variational autoencoders with triplet loss: a COVID-19 prognosis study.

Sci Rep

2023 Feb 17

Mahdavi M(#), Choubdar H(#), Rostami Z

714. Atypical changes in Candida albicans cells treated with the Venetin-1 complex from earthworm coelomic fluid.

Sci Rep

2023 Feb 17

Wójcik-Mieszawska S, Lewtak K, Sofińska-Chmiel W

715. Network coevolution drives segregation and enhances Pareto optimal equilibrium selection in coordination games.

Sci Rep

2023 Feb 17

González Casado MA, Sánchez A, San Miguel M.

716. Prostate cancer cell-platelet bidirectional signaling promotes calcium mobilization, invasion and apoptotic resistance via distinct receptor-ligand pairs.

Sci Rep

2023 Feb 17

Garofano K, Rashid K, Smith M

Platelets play a crucial role in cancer and thrombosis. However, the receptor-ligand repertoire mediating prostate cancer (PCa) cell-platelet interactions and ensuing consequences have not been fully elucidated. Microvilli emanating from the plasma membrane of PCa cell lines (RC77 T/E, MDA PCa 2b) directly contacted individual platelets and platelet aggregates. PCa cell-platelet interactions were associated with calcium mobilization in platelets, and translocation of P-selectin and integrin αIIbβ3 onto the platelet surface. PCa cell-platelet interactions reciprocally promoted PCa cell invasion and apoptotic resistance, and these events were insensitive to androgen receptor blockade by bicalutamide. PCa cells were exceedingly sensitive to activation by platelets in vitro, occurring at a PCa cell:platelet coculture ratio as low as 1:10 (whereas PCa patient blood contains 1:2,000,000 per ml). Conditioned medium from cocultures stimulated PCa cell invasion but not apoptotic resistance nor platelet aggregation. Candidate transmembrane signaling proteins responsible for PCa cell-platelet oncogenic events were identified by RNA-Seq and broadly divided into 4 major categories: (1) integrin-ligand, (2) EPH receptor-ephrin, (3) immune checkpoint receptor-ligand, and (4) miscellaneous receptor-ligand interactions. Based on antibody neutralization and small molecule inhibitor assays, PCa cell-stimulated calcium mobilization in platelets was found to be mediated by a fibronectin1 (FN1)-αIIbβ3 signaling axis. Platelet-stimulated PCa cell invasion was facilitated by a CD55-adhesion G protein coupled receptor E5 (ADGRE5) axis, with contribution from platelet cytokines CCL3L1 and IL32. Platelet-stimulated PCa cell apoptotic resistance relied on ephrin-EPH receptor and lysophosphatidic acid (LPA)-LPA receptor (LPAR) signaling. Of participating signaling partners, FN1 and LPAR3 overexpression was observed in PCa specimens compared to normal prostate, while high expression of CCR1 (CCL3L1 receptor), EPHA1 and LPAR5 in PCa was associated with poor patient survival. These findings emphasize that non-overlapping receptor-ligand pairs participate in oncogenesis and thrombosis, highlighting the complexity of any contemplated clinical intervention strategy.

717. Baseline characteristics in the Israel refraction, environment, and devices (iREAD) study.

Sci Rep

2023 Feb 17

Shneor E, Ostrin LA, Doron R

718. Rapid shift in greenhouse forcing of emerging arctic peatlands.

Sci Rep

2023 Feb 17

Christensen TR, Scheller J, Scheel M

719. Inflammatory biomarkers, angiogenesis and lymphangiogenesis in epicardial adipose tissue correlate with coronary artery disease.

Sci Rep

2023 Feb 17

Si Y, Feng Z, Liu Y

720. Electrically conductive scaffolds mimicking the hierarchical structure of cardiac myofibers.

Sci Rep

2023 Feb 17

Ul Haq A, Montaina L, Pescosolido F

721. Quantitative proteomic analysis of human serum using tandem mass tags to predict cardiovascular risks in patients with psoriasis.

Sci Rep

2023 Feb 17

Kim NY(#), Back JH(#), Shin JH

722. RNA independent fragment partition method based on deep learning for RNA secondary structure prediction.

Sci Rep

2023 Feb 17

Zhao Q, Mao Q, Zhao Z

723. The simplified tailor-made workflows for a 3D slicer-based craniofacial implant design.

Sci Rep

2023 Feb 17

Tantisatirapong S, Khunakornpattanakarn S, Suesatsakul T

724. Improving the efficiency of crossbred Pradu Hang Dam chicken production for meat consumption using cold plasma technology on eggs.

Sci Rep

2023 Feb 17

Sakulthai A, Sawangrat C, Pichpol D

725. An insight into synthesis and antitumor activity of citrate and gallate stabilizing gold nanospheres.

Sci Rep

2023 Feb 16

Fathy MM, Elfiky AA, Bashandy YS

726. The association between egg consumption and metabolic health status in overweight and obese adolescents.

Sci Rep

2023 Feb 16

Tabatabaeyan A, Lotfi K, Mirzaei S

727. Industrial upgrading and its influence on green land use efficiency.

Sci Rep

2023 Feb 16

Chang J, Wang W, Liu J.

728. The permanent magnet hypothesis: an intuitive approach to designing non-circular magnet arrays with high field homogeneity.

Sci Rep

2023 Feb 16

Tewari S, Webb A.

729. Ischemic stroke protected by ISO-1 inhibition of apoptosis via mitochondrial pathway.

Sci Rep

2023 Feb 16

Ji W, Ren Y, Wei X

730. Fungal cell barriers and organelles are disrupted by polyhexamethylene biguanide (PHMB).

Sci Rep

2023 Feb 16

Ntow-Boahene W, Papandronicou I, Miculob J

731. Combination of treatments with transoral endoscopic thyroidectomy vestibular approach (TOETVA) for Graves' disease.

Sci Rep

2023 Feb 16

Wu YJ, Chang YH, Tsai C

732. Ideal cardiovascular health and all-cause or cardiovascular mortality in a longitudinal study of the Thai National Health Examination Survey IV and V.

Sci Rep

2023 Feb 16

Aekplakorn W, Neelapaichit N, Chariyalertsak S

733. Wavefront shaping with nonlinear four-wave mixing.

Sci Rep

2023 Feb 16

Shen D, Cao J, Wan W.

734. Long-term sentinel surveillance of enteroviruses in Gwangju, South Korea, 2011-2020.

Sci Rep

2023 Feb 16

Kim MJ, Lee JE, Kim KG

735. Investigation of the spatial and temporal variation of soil salinity using Google Earth Engine: a case study at Werigan-Kuqa Oasis, West China.

Sci Rep

2023 Feb 16

Ma S, He B, Xie B

Large-scale soil salinity surveys are time-costly and labor-intensive, and it is also more difficult to investigate historical salinity, while in arid and semi-arid regions, the investigation of the spatial and temporal characteristics of salinity can provide a scientific basis for the scientific prevention of salinity, With this objective, this study uses multi-source data combined with ensemble learning and Google Earth Engine to build a monitoring model to observe the evolution of salinization in the Werigan-Kuqa River Oasis from 1996 to 2021 and to analyze the driving factors. In this experiment, three ensemble learning models, Random Forest (RF), Extreme Gradient Boosting (XGBoost), and Light Gradient Boosting Machine (LightGBM), were established using data collected in the field for different years and some environmental variables, After the accuracy validation of the model, XGBoost had the highest accuracy of salinity prediction in this study area, with RMSE of 17.62 dS m-1, R2 of 0.73 and RPIQ of 2.45 in the test set. In this experiment, after Spearman correlation analysis of soil Electrical Conductivity (EC) with environmental variables, we found that the near-infrared band in the original band, the DEM in the topographic factor, the vegetation index based on remote sensing, and the salinity index soil EC had a strong correlation. The spatial distribution of salinization is generally characterized by good in the west and north and severe in the east and south. Non-salinization, light salinization, and moderate salinization gradually expanded southward and eastward from the interior of the western oasis over 25 years. Severe and very severe salinization gradually shifted from the northern edge of the oasis to the eastern and southeastern desert areas during the 25 years. The saline soils with the highest salinity class were distributed in most of the desert areas in the eastern part of the Werigan-Kuqa Oasis study area as well as in smaller areas in the west in 1996, shrinking in size and characterized by a discontinuous distribution by 2021. In terms of area change, the non-salinized area increased from 198.25 in 1996 to 1682.47 km2 in 2021. The area of saline soil with the highest salinization level decreased from 5708.77 in 1996 to 2246.87 km2 in 2021. overall, the overall salinization of the Werigan-Kuqa Oasis improved.

736. Protective effects of Pudilan Tablets against osteoarthritis in mice induced by monosodium iodoacetate.

Sci Rep

2023 Feb 16

Fang Z(#), Li X(#), Lei S

737. The spatial distribution of GPCR and Gβγ activity across a cell dictates PIP3 dynamics.

Sci Rep

2023 Feb 16

Wijayaratna D, Ratnayake K, Ubeysinghe S

738. Direct observation of electric field-induced magnetism in a molecular magnet.

Sci Rep

2023 Feb 16

Lewkowitz M, Adams J, Sullivan NS

739. The deficiency of poly-β-1,6-N-acetyl-glucosamine deacetylase trigger A. baumannii to convert to biofilm-independent colistin-tolerant cells.

Sci Rep

2023 Feb 16

Lai SJ, Tu IF, Tseng TS

740. Microvasculature evaluation of anisometropic amblyopia children by Angio-OCT.

Sci Rep

2023 Feb 16

Ye H, Wang S, Zhang Y

741. Optimized protocol for MALDI MSI of N-glycans using an on-tissue digestion in fresh frozen tissue sections.

Sci Rep

2023 Feb 16

Grgic A(#), Krestensen KK(#), Heeren RMA.

742. Quitting smoking after a cancer diagnosis is associated with high-risk neutrophil-to-lymphocyte ratio among tobacco use-related cancer survivors.

Sci Rep

2023 Feb 16

Lu Y, Kwong K, Wells J

743. Risk of gout attack not increased in patients with thalassemia: a population-based cohort study.

Sci Rep

2023 Feb 16

Chen JW(#), Xu Q(#), Yang PD

The incidence of gout arthritis in patients with thalassemia and the association between them was indefinite. We aimed to give epidemiological evidence regarding the association between thalassemia and gout arthritis. This retrospective cohort study extracted data relating to the risk of gout arthritis from patients diagnosed with thalassemia between 2000 and 2013. We selected the control group at a ratio of 1:4 by propensity score matching (PSM). Univariable and multivariable Cox proportional hazard regression models were performed to analyze the association between thalassemia and gout arthritis and to evaluate the hazard ratio (HR) of gout arthritis after exposure with thalassemia. The sensitivity analysis was performed to avoid the mislabeled thalassemia disease, the transfusion-dependent thalassemia was classified to compare the risk of gout arthritis. The secondary outcome for the risk of gout arthritis with antigout drugs treatment was also evaluated between study groups. In the age and sex matched cohort, the majority of thalassemia patients were women (62.03%) and aged younger than 30 years old (44.79%). There were 138 (4.2%) and 500 (3.8%) incident cases of gout arthritis in the thalassemia and non-thalassemia group. After PSM, the incidence rate, per 100 person-years, of gout arthritis was 0.48 (95% CI 0.42 to 0.56) and 0.60 (95% CI 0.51 to 0.72) in non-thalassemia individuals and patients with thalassemia, respectively. In the Cox proportional hazard regression, patients with thalassemia had no significant increase in the risk of gout arthritis (adjusted HR, 1.00; 95%CI: 0.80 to 1.25) after adjusting demographic variables and comorbidities. The Kaplan-Meier curve showed that the cumulative incidence of gout arthritis was not a significant difference in the thalassemia group than in the comparison group (p > 0.05). The sensitivity analysis showed the consistent results about the risk of gout arthritis in patients with thalassemia. Our study indicated that there was no significant increase in the risk of gout arthritis in subjects with thalassemia.Future research needs to clarify the biological mechanisms behind this connection.

744. Optimized workplace risk mitigation measures for SARS-CoV-2 in 2022.

Sci Rep

2023 Feb 16

Pettit R(#), Peng B(#), Yu P

596 million SARS-CoV-2 cases have been reported and over 12 billion vaccine doses have been administered. As vaccination rates increase, a gap in knowledge exists regarding appropriate thresholds for escalation and de-escalation of workplace COVID-19 preventative measures. We conducted 133,056 simulation experiments, evaluating the spread of SARS-CoV-2 virus in hypothesized working environments subject to COVID-19 infections from the community. We tested the rates of workplace-acquired infections based on applied isolation strategies, community infection rates, methods and scales of testing, non-pharmaceutical interventions, variant predominance, vaccination coverages, and vaccination efficacies. When 75% of a workforce is vaccinated with a 70% efficacious vaccine against infection, then no masking or routine testing + isolation strategies are needed to prevent workplace-acquired omicron variant infections when the community infection rate per 100,000 persons is ≤ 1. A CIR ≤ 30, and ≤ 120 would result in no workplace-acquired infections in this same scenario against the delta and alpha variants, respectively. Workforces with 100% worker vaccination can prevent workplace-acquired infections with higher community infection rates. Identifying and isolating workers with antigen-based SARS-CoV-2 testing methods results in the same or fewer workplace-acquired infections than testing with slower turnaround time polymerase chain reaction methods. Risk migration measures such as mask-wearing, testing, and isolation can be relaxed, or escalated, in commensurate with levels of community infections, workforce immunization, and risk tolerance. The interactive heatmap we provide can be used for immediate, parameter-based case count predictions to inform institutional policy making. The simulation approach we have described can be further used for future evaluation of strategies to mitigate COVID-19 spread.

745. The importance of cultural tailoring of communicators and media outlets in an influenza vaccination awareness campaign: a digital randomized trial.

Sci Rep

2023 Feb 16

Habib GL, Yousuf H, Bredius L

746. IRF4 as a novel target involved in malignant transformation of oral submucous fibrosis into oral squamous cell carcinoma.

Sci Rep

2023 Feb 16

Meng L(#), Jiang Y(#), You J(#)

747. The impact of feeding supplemental minerals to sheep on the return of micronutrients to pasture via urine and faeces.

Sci Rep

2023 Feb 16

Kao PT, Fleming H, Warren H

748. Effect of fluid overload on survival in patients with sepsis-induced acute kidney injury receiving continuous renal replacement therapy.

Sci Rep

2023 Feb 16

Kim IY, Kim S, Ye BM

749. CD47 antisense oligonucleotide treatment attenuates obesity and its-associated metabolic dysfunction.

Sci Rep

2023 Feb 16

Gwag T(#), Li D(#), Ma E

750. Association between knee osteoarthritis and the risk of cardiovascular disease and the synergistic adverse effects of lack of exercise.

Sci Rep

2023 Feb 16

Park D, Park YM, Ko SH

751. Deep learning for the ovarian lesion localization and discrimination between borderline and malignant ovarian tumors based on routine MR imaging.

Sci Rep

2023 Feb 16

Wang Y(#), Zhang H(#), Wang T

752. Establishment of a rabbit liver metastasis model by percutaneous puncture of the spleen and implantation of the VX2 tumor strain under CT guidance.

Sci Rep

2023 Feb 16

Li B(#), Feng G(#), Feng L(#)

This study aimed to compare the feasibility, success rate, and safety of establishing a rabbit VX2 liver metastasis model by percutaneous splenic implantation under CT guidance and open splenic implantation of the VX2 tumor strain. Fifty-two New Zealand white rabbits were randomly divided into group A (the percutaneous puncture group) (n = 26) and group B (the laparotomy group) (n = 26). In group A, 26 New Zealand white rabbits were implanted with tumor strains by percutaneous splenic puncture under CT guidance. In group B, 26 New Zealand white rabbits were implanted with tumor strains in the spleen by laparotomy. After 2-3 weeks of implantation, both group A and group B underwent MRI to confirm tumor growth in the spleen and metastasis to the liver. Two experimental rabbits randomly selected from groups A and B were killed for pathological examination. The success rate, complication rate, and operation time in groups A and B were compared and analyzed. A total of 23 rabbits in group A were successfully induced, and the success rate was 88.5% (23/26). The average time of operation was 14.42 ± 3.26 min. A total of 22 rabbits in group B were successfully induced, and the success rate was 84.6% (22/26). The average time of operation in group B was 23.69 ± 5.27 min. There was no significant difference in the success rate of induction between the two groups (P > 0.05). The MRI manifestations of liver metastases were multiple nodular and punctate abnormal signal shadows in the liver. Hematoxylin-eosin (HE) staining showed a large number of tumor cells in the tumor area. CT-guided percutaneous splenic implantation of the VX2 tumor strain to establish a rabbit liver metastasis model is a minimally invasive and feasible inducing method. The success rate of this technique is not lower than that of open splenic implantation, with low incidence of complications, and short operation time.

753. Info-gap theory to determine cost-effective eradication of invasive species.

Sci Rep

2023 Feb 16

Liu Y, Thomas ML, Coupland GT

754. Iron (hydr)oxide formation in Andosols under extreme climate conditions.

Sci Rep

2023 Feb 16

Klaes B, Thiele-Bruhn S, Wörner G

755. Automatic dispersion, defect, curing, and thermal characteristics determination of polymer composites using micro-scale infrared thermography and machine learning algorithm.

Sci Rep

2023 Feb 16

Rahman MA, Rahman MM, Ashraf A.

756. Parental education, cognition and functional connectivity of the salience network.

Sci Rep

2023 Feb 16

Cermakova P, Chlapečka A, Csajbók Z

757. Inhibition of inflammatory microglia by dietary fiber and short-chain fatty acids.

Sci Rep

2023 Feb 16

Caetano-Silva ME, Rund L, Hutchinson NT

758. Radiomics analysis of contrast-enhanced T1W MRI: predicting the recurrence of acute pancreatitis.

Sci Rep

2023 Feb 16

Tang L(#), Ma L(#), Chen Y

759. Discrete optimal quadratic AGC based cost functional minimization for interconnected power systems.

Sci Rep

2023 Feb 16

Esmail M, Krishnamurthy S.

The increasing complexity and difficulty of the Automatic generation control (AGC) problem has resulted from the increasing scale of interconnected power networks and changing daily demands. The primary goals of AGC are to control frequency variations at nominal levels and tie-line power variances at planned levels. To effectively deal with AGC control difficulties, this study introduces Discrete Optimal Quadratic Automatic Generation Control (OQAGC). One advantages of this method is the differentiation of quadratic cost function results into linear terms while minimizing control actions and minimizing state deviations. This developed control method leads to a simple and easy discrete control law that can be implemented for both linear and nonlinear systems. For optimizing the controller, this research work utilized an optimum control theorem using Lagrangian multipliers, while the functional minimization technique is used for systematically selecting the state and control weighting matrices in discrete form for N control regions (where N is the number of interconnected power systems). The discrete cost function needs are derived using this technique in terms of area control errors, integral area control errors, and control energy expenditure. Four interconnected power systems were analyzed with/without disturbances and area control errors, each with one thermal, hydro, and gas-generating unit. A two-area multi-source power system with renewable energy in control area 2 is analyzed for the performance of the proposed controller with generation rate constraints (GRCs). The functional minimization technique simplifies and eases the choosing of weighting matrices. Furthermore, the simulation findings suggest that the developed discrete optimum quadratic AGC control-based cost functional minimization approach enhances power system dynamics in terms of stability, steady-state performance, and the closed-loop control system's robustness to input load disturbances. As a result, the newly developed OQAGC approach demonstrates the significance of the discrete LQR controller for N multi-area power systems.

760. 1'-O-methyl-averantin isolated from the endolichenic fungus Jackrogersella sp. EL001672 suppresses colorectal cancer stemness via sonic Hedgehog and Notch signaling.

Sci Rep

2023 Feb 16

Varlı M, Lee EY, Yang Y

761. Methodology for estimation of undeformed thickness of arterial tissues.

Sci Rep

2023 Feb 16

Schwarz D, Fleisman J, Vitasek R

762. Unravelling microalgal-bacterial interactions in aquatic ecosystems through 16S rRNA gene-based co-occurrence networks.

Sci Rep

2023 Feb 16

Pushpakumara BLDU, Tandon K, Willis A

763. Coordinate value of the femoral head center estimated using those of the tip of the greater trochanter and lesser trochanter.

Sci Rep

2023 Feb 16

Imai N, Kimura K, Sakagami A

764. Chitosan bead containing metal-organic framework encapsulated heteropolyacid as an efficient catalyst for cascade condensation reaction.

Sci Rep

2023 Feb 16

Sadjadi S, Abedian-Dehaghani N, Heydari A

765. A comparison between asymptomatic and symptomatic ureteral stones.

Sci Rep

2023 Feb 16

Noh TI, Pyun JH, Shim JS

To investigate the characteristics and impact of asymptomatic (silent) ureteral stones on renal function and compare them with those of symptomatic stones. We retrospectively reviewed the medical records of 677 patients who underwent ureteroscopic lithotripsy or laparoscopic ureterolithotomy for ureteral stones between 2016 and 2020. Patients were divided into two groups according to the presence of recognizable symptoms. We investigated the characteristics and impact of silent stones on post-treatment renal function recovery and compared them with those of symptomatic stones. Among the 677 patients, 43 (6.4%) had asymptomatic ureteral stones, and 634 (93.6%) had symptomatic ureteral stones. Compared to symptomatic stones, asymptomatic stones were larger (11.4 mm vs. 9.6 mm, p = 0.003), more commonly present in the upper ureter (62.7% vs. 48.0%, p = 0.04), and more commonly associated with high-grade hydronephrosis (32.8% vs. 12.3%, p < 0.001); however, no difference in metabolite composition was observed between the two group of stone. In the asymptomatic stone group, the mean preoperative estimated glomerular filtration rate (eGFR) was 77.37 ± 23.54 mL/min/1.73 m2, and the mean postoperative eGFR indicated no significant improvement at 1 day, 7 days, 3 months, and 12 months (76.66 ± 21.45, 77.89 ± 20.87, 77.29 ± 22.22, and 76.71 ± 24.21 mL/min/1.73 m2, respectively; p = 0.567, p = 0.613, p = 0.924, and p = 0.202, respectively). In the symptomatic stone group, the mean preoperative eGFR was 78.17 ± 28.25 mL/min/1.73 m2; the mean postoperative eGFRs at 1 day, 7 days, 3 months, and 12 months were 81.24 ± 26.38, 86.16 ± 25.61, 89.11 ± 25.43, and 89.50 ± 26.01 mL/min/1.73 m2, respectively and demonstrated significant improvement (p = 0.002, p < 0.001, p < 0.001, and p < 0.001, respectively). Silent stones irreversibly impaired renal function, even after proper management. Therefore, active treatment strategies are required for all patients who are hesitant to receive treatment for silent stones because of their asymptomatic status to prevent permanent renal impairment.

766. Electric impedance tomography and protective mechanical ventilation in elective robotic-assisted laparoscopy surgery with steep Trendelenburg position: a randomized controlled study.

Sci Rep

2023 Feb 16

Buonanno P, Marra A, Iacovazzo C

767. Nicotinamide adenine dinucleotide metabolism and arterial stiffness after long-term nicotinamide mononucleotide supplementation: a randomized, double-blind, placebo-controlled trial.

Sci Rep

2023 Feb 16

Katayoshi T, Uehata S, Nakashima N

768. Population genetic structure of a recent insect invasion: a gall midge, Asynapta groverae (Diptera: Cecidomyiidae) in South Korea since the first outbreak in 2008.

Sci Rep

2023 Feb 16

Kang JH, Ham D, Park SH

769. Association between daily gait speed patterns and cognitive impairment in community-dwelling older adults.

Sci Rep

2023 Feb 16

Seo K, Takayanagi N, Sudo M

770. Mexican traditional medicines for women's reproductive health.

Sci Rep

2023 Feb 16

Cabada-Aguirre P, López López AM, Mendoza KCO

Like China, Mexico has a traditional system of medicine dating back almost 5000 years that incorporates the healing practices of pre-Columbian civilizations, including the Maya and Aztec. Mexican Traditional Medicine (MTM) women depend on MTM practices and herbal medicines for their primary healthcare needs as limited access and high costs of Western medicine is a significant problem. The aims of this work were to determine the medicinal plants more commonly used in MTM for women's reproductive health issues and assess the clinical data supporting their use. Data from multiple sources was compiled and information on plants commonly used by women in Mexico MTM for the treatment of fertility and menstruation issues, pregnancy, and menopause was analyzed. Analysis of the data show that 185 species of plants representing > 60 families were used for a wide range of reproductive health issues. Some of these plants have been used in MTM for fertility regulation in women of which 35 species were used as emmenagogues and abortifacients. Approximate 40 species were used for the symptoms of premenstrual syndrome, heavy menstrual bleeding, and dysmenorrhea. In terms of pregnancy, 35 species were used for postpartum care and to facilitate breastfeeding, 16 species were used as oxytocic agents to induce labor and speed birth, and six plant species were used to prevent miscarriage. Fourteen plant species were reported to treat infertility or promote fertility, and seven species were used to treat uterine prolapse. Three plants species were reported to treat menopause and two plants were used for osteoporosis. Analysis of the clinical data for commonly used medicinal plants showed some clinical support for the use of these plants in MTM. In Mexico, women use medicinal plants for almost every aspect of reproductive health. While some plants have clinical data, most medicinal plants used in MTM have no safety or efficacy data available and could serve as the basis of future investigations.

771. Phytohormones regulate the non-redundant response of ω-3 fatty acid desaturases to low temperatures in Chorispora bungeana.

Sci Rep

2023 Feb 16

Shi Y, Yang S, Zhao Z

772. Preschool children aged 4 to 5 years show discomfort with trypophobic images.

Sci Rep

2023 Feb 16

Suzuki C, Shirai N, Sasaki K

773. Climate-driven convergent evolution in riparian ecosystems on sky islands.

Sci Rep

2023 Feb 16

Love SJ, Schweitzer JA, Bailey JK.

774. Impact of the SARS-CoV-2 pandemic on the survival of patients with high-grade glioma and best practice recommendations.

Sci Rep

2023 Feb 16

Vogel MME, Wagner A, Gempt J

775. Spontaneous action matching in dog puppies, kittens and wolf pups.

Sci Rep

2023 Feb 16

Fugazza C, Temesi A, Coronas R

776. Dynamics of stochastic-constrained particles.

Sci Rep

2023 Feb 16

Guo T.

777. No evidence for the benefit of PPIs in the treatment of acute pancreatitis: a systematic review and meta-analysis.

Sci Rep

2023 Feb 16

Horváth IL, Bunduc S, Hankó B

778. Metagenomic mapping of cyanobacteria and potential cyanotoxin producing taxa in large rivers of the United States.

Sci Rep

2023 Feb 16

Linz DM, Sienkiewicz N, Struewing I

779. Agricultural dust derived bacterial extracellular vesicle mediated inflammation is attenuated by DHA.

Sci Rep

2023 Feb 16

Heires AJ, Samuelson D, Villageliu D

Dietary long-chain omega-3 polyunsaturated fatty acids (n-3 PUFA) and their pro-resolving metabolites are protective against atherosclerotic disease, and ameliorate systemic inflammatory conditions including lupus erythematosus, psoriasis, and bronchial asthma. Organic bioaerosol inhalation is a common and injurious hazard associated with agricultural occupations such as work in swine concentrated animal feeding operations (CAFOs) and is known to increase the risk for developing respiratory conditions such as asthma and COPD. Nearly all cells secrete membrane-bound vesicles (extracellular vesicles, EVs) that have the capacity to transmit protein, nucleic acid, and lipid signaling mediators between cells. Using a polymer-based isolation technique (ExoQuick, PEG) followed by ultracentrifugation, EVs were isolated from CAFO dust extracts, and were quantified and partially characterized. Here, we investigated the role of the n-3 PUFA docosahexaenoic acid (DHA) as a component of n-6 to n-3 PUFA mixtures used to recapitulate physiologically relevant dietary ratios in the resolution of inflammatory injury caused by exposure to EVs carried by agricultural organic dust in vitro. Primary human bronchial epithelial cells, fibroblasts and monocyte-derived macrophages were exposed to EVs isolated from swine CAFO dust. Cells were treated with mixtures of n-6 and n-3 PUFA during recovery from the EV-induced injury. CAFO dust extract (DE) was found to contain EVs that contributed significantly to the overall consequences of exposure to complete DE. DHA-rich PUFA ratios inhibited DE-derived EV-induced proinflammatory cytokine release dose-dependently. DHA-rich PUFA ratios also reversed the damaging effects of EVs on recellularization of lung matrix scaffolds, accelerated wound healing, and stimulated the release of pro-resolution mediators. These results underscore the importance of n-3 PUFA as anti-inflammatory compounds during recovery from EV-laden environmental dust exposure in the context of cellular responses in vitro, warranting future translational studies.

780. Deep reinforcement learning-based pairwise DNA sequence alignment method compatible with embedded edge devices.

Sci Rep

2023 Feb 16

Lall A, Tallur S.

781. Correlation of monocyte counts with clinical outcomes in idiopathic nonspecific interstitial pneumonia.

Sci Rep

2023 Feb 16

Kim TH, Kim HJ, Song MJ

782. Effect of membrane depolarization against Aspergillus niger GM31 resistant by ultra nanoclusters characterized by Ag(2+) and Ag(3+) oxidation state.

Sci Rep

2023 Feb 15

Molina Hernandez JB, Scotti L, Valbonetti L

783. Surface profile analysis of laminated transfemoral prosthetic socket fabricated with different ratios of epoxy resin and acrylic resin.

Sci Rep

2023 Feb 15

Zainuddin NAMN, Razak NAA, Karim MSA

784. The interplay between spatiotemporal overlap and morphology as determinants of microstructure suggests no 'perfect fit' in a bat-flower network.

Sci Rep

2023 Feb 15

Diniz UM, Aguiar LMS.

785. Determination of optimum dose based of biological responses of lethal dose (LD(25, 50, 75)) and growth reduction (GR(25, 50, 75)) in 'Yaghouti' grape due to gamma radiation.

Sci Rep

2023 Feb 15

Ghasemi-Soloklui AA, Kordrostami M, Karimi R.

786. Development of Self-Active Aging Index (S-AAI) among rural elderly in lower northern Thailand classified by age and gender.

Sci Rep

2023 Feb 15

Keeratisiroj O, Kitreerawutiwong N, Mekrungrongwong S.

787. Effects of saccade delay, side of deficit, and training on detection of catch-up saccades during head-impulse test in virtual-reality-enhanced mannequin.

Sci Rep

2023 Feb 15

Charlery-Adèle A, Guigou C, Ryard J

788. Improvement of trip generation rates for mixed-use development in Klang Valley, Malaysia.

Sci Rep

2023 Feb 15

Goh BH, Yuen CW, Onn CC.

789. SPLIT-PIN software enabling confocal and super-resolution imaging with a virtually closed pinhole.

Sci Rep

2023 Feb 15

Di Franco E, Costantino A, Cerutti E

790. Studying the connection between SF3B1 and four types of cancer by analyzing networks constructed based on published research.

Sci Rep

2023 Feb 15

Samy A, Ozdemir MK, Alhajj R.

791. Integrated multiple microarray studies by robust rank aggregation to identify immune-associated biomarkers in Crohn's disease based on three machine learning methods.

Sci Rep

2023 Feb 15

Chen ZA(#), Ma HH(#), Wang Y

Crohn's disease (CD) is a complex autoimmune disorder presumed to be driven by complex interactions of genetic, immune, microbial and even environmental factors. Intrinsic molecular mechanisms in CD, however, remain poorly understood. The identification of novel biomarkers in CD cases based on larger samples through machine learning approaches may inform the diagnosis and treatment of diseases. A comprehensive analysis was conducted on all CD datasets of Gene Expression Omnibus (GEO); our team then used the robust rank aggregation (RRA) method to identify differentially expressed genes (DEGs) between controls and CD patients. PPI (protein‒protein interaction) network and functional enrichment analyses were performed to investigate the potential functions of the DEGs, with molecular complex detection (MCODE) identifying some important functional modules from the PPI network. Three machine learning algorithms, support vector machine-recursive feature elimination (SVM-RFE), random forest (RF), and least absolute shrinkage and selection operator (LASSO), were applied to determine characteristic genes, which were verified by ROC curve analysis and immunohistochemistry (IHC) using clinical samples. Univariable and multivariable logistic regression were used to establish a machine learning score for diagnosis. Single-sample GSEA (ssGSEA) was performed to examine the correlation between immune infiltration and biomarkers. In total, 5 datasets met the inclusion criteria: GSE75214, GSE95095, GSE126124, GSE179285, and GSE186582. Based on RRA integrated analysis, 203 significant DEGs were identified (120 upregulated genes and 83 downregulated genes), and MCODE revealed some important functional modules in the PPI network. Machine learning identified LCN2, REG1A, AQP9, CCL2, GIP, PROK2, DEFA5, CXCL9, and NAMPT; AQP9, PROK2, LCN2, and NAMPT were further verified by ROC curves and IHC in the external cohort. The final machine learning score was defined as [Expression level of AQP9 × (2.644)] + [Expression level of LCN2 × (0.958)] + [Expression level of NAMPT × (1.115)]. ssGSEA showed markedly elevated levels of dendritic cells and innate immune cells, such as macrophages and NK cells, in CD, consistent with the gene enrichment results that the DEGs are mainly involved in the IL-17 signaling pathway and humoral immune response. The selected biomarkers analyzed by the RRA method and machine learning are highly reliable. These findings improve our understanding of the molecular mechanisms of CD pathogenesis.

792. Intestinal epithelial barrier integrity investigated by label-free techniques in ulcerative colitis patients.

Sci Rep

2023 Feb 15

Quansah E(#), Gardey E(#), Ramoji A(#)

793. A randomized trial on the effect of transcutaneous electrical nerve stimulator on glycemic control in patients with type 2 diabetes.

Sci Rep

2023 Feb 15

Lu JY, Ou HY, Wu CZ

794. Experimental analysis of recommended corneal incision sizes in cataract surgery using 13 intraocular lens injector systems.

Sci Rep

2023 Feb 15

Friedrich M, Auffarth GU, Merz PR.

795. Association of glaucoma and lifestyle with incident cardiovascular disease: a longitudinal prospective study from UK Biobank.

Sci Rep

2023 Feb 15

Choi JA, Lee SN, Jung SH

796. The degree of urbanisation reduces wild bee and butterfly diversity and alters the patterns of flower-visitation in urban dry grasslands.

Sci Rep

2023 Feb 15

Herrmann J, Buchholz S, Theodorou P.

797. Seasonal variation in the lipid content of Fraser River Chinook Salmon (Oncorhynchus tshawytscha) and its implications for Southern Resident Killer Whale (Orcinus orca) prey quality.

Sci Rep

2023 Feb 15

Lerner JE, Hunt BPV.

798. Digestive enzymes and sphingomyelinase D in spiders without venom (Uloboridae).

Sci Rep

2023 Feb 15

Valladão R, Neto OBS, de Oliveira Gonzaga M

799. CRISPR/Cas9-mediated targeted knock-in of large constructs using nocodazole and RNase HII.

Sci Rep

2023 Feb 15

Eghbalsaied S, Kues WA.

800. Effects of activation energy and chemical reaction on unsteady MHD dissipative Darcy-Forchheimer squeezed flow of Casson fluid over horizontal channel.

Sci Rep

2023 Feb 15

Li S, Raghunath K, Alfaleh A

801. Passive flow control via tip grooving and stall fencing mechanisms of a marine energy harvesting turbine.

Sci Rep

2023 Feb 15

Das TK, Islam N, Samad A

802. Nasopharyngeal SARS-CoV-2 may not be dispersed by a high-flow nasal cannula.

Sci Rep

2023 Feb 15

Suzuki T, Morioka S, Yamamoto K

803. Predictors of shoulder dystocia at the time of operative vaginal delivery: a prospective cohort study.

Sci Rep

2023 Feb 15

Bouchghoul H, Hamel JF, Mattuizzi A

804. Targeting mTOR to overcome resistance to hormone and CDK4/6 inhibitors in ER-positive breast cancer models.

Sci Rep

2023 Feb 15

Rodriguez MJ, Perrone MC, Riggio M

805. Anti-DEspR antibody treatment improves survival and reduces neurologic deficits in a hypertensive, spontaneous intracerebral hemorrhage (hsICH) rat model.

Sci Rep

2023 Feb 15

Herrera VLM, Gromisch CM, Decano JL

806. Effect of fissure angle on energy evolution and failure characteristics of fractured rock under uniaxial cyclic loading.

Sci Rep

2023 Feb 15

Zhao Y, Li Q, Zhang K

807. Mixture effects of thiamethoxam and seven pesticides with different modes of action on honey bees (Aplis mellifera).

Sci Rep

2023 Feb 15

Li W, Lv L, Wang Y

808. A proof of principle study using radiopharmaceuticals to quantify and localize container-content interactions in medical syringes.

Sci Rep

2023 Feb 15

Dupire C(#), Chennell P(#), Pereira B

809. A straightforward method to quantify circulating mRNAs as biomarkers of colorectal cancer.

Sci Rep

2023 Feb 15

Grosgeorges M(#), Picque Lasorsa L(#), Pastor B(#)

810. Restoring speech intelligibility for hearing aid users with deep learning.

Sci Rep

2023 Feb 15

Diehl PU, Singer Y, Zilly H

811. Validation of an MD simulation approach for electrical field responsive micelles and their application in drug delivery.

Sci Rep

2023 Feb 15

Razavi L, Raissi H, Farzad F.

812. Reliability‑based probabilistic numerical plastically limited analysis of reinforced concrete haunched beams.

Sci Rep

2023 Feb 15

Khaleel Ibrahim S, Movahedi Rad M.

813. Application of a physiologically based pharmacokinetic model in predicting captopril disposition in children with chronic kidney disease.

Sci Rep

2023 Feb 15

Khalid S, Rasool MF, Masood I

814. AcrAB efflux pump impacts on the survival of adherent-invasive Escherichia coli strain LF82 inside macrophages.

Sci Rep

2023 Feb 15

Fanelli G, Pasqua M, Prosseda G

815. Automatic diagnosis of retention pseudocyst in the maxillary sinus on panoramic radiographs using a convolutional neural network algorithm.

Sci Rep

2023 Feb 15

Ha EG(#), Jeon KJ(#), Choi H

816. Classification of electrically-evoked potentials in the parkinsonian subthalamic nucleus region.

Sci Rep

2023 Feb 15

Rosing J, Doyle A, Brinda A

817. Hydrodynamic Kelvin-Helmholtz instability on metallic surface.

Sci Rep

2023 Feb 15

Wang X, Hu XM, Wang ST

818. Stability evaluation and validation of appropriate reference genes for real-time PCR expression analysis of immune genes in the rohu (Labeo rohita) skin following argulosis.

Sci Rep

2023 Feb 15

Sahoo PK, Parida S, Parida S

819. Evaluation of polyanionic cyclodextrins as high affinity binding scaffolds for fentanyl.

Sci Rep

2023 Feb 15

Mayer BP, Kennedy DJ, Lau EY

820. NMR-based metabolomics of plasma from dairy calves infected with two primary causal agents of bovine respiratory disease (BRD).

Sci Rep

2023 Feb 15

Santos-Rivera M, Fitzkee NC, Hill RA

821. Classification of emotional stress and physical stress using a multispectral based deep feature extraction model.

Sci Rep

2023 Feb 15

Hong K.

822. Butyrate limits human natural killer cell effector function.

Sci Rep

2023 Feb 15

Zaiatz-Bittencourt V, Jones F, Tosetto M

823. Morpho-physiological and biochemical response of wheat to various treatments of silicon nano-particles under drought stress conditions.

Sci Rep

2023 Feb 15

Raza MAS, Zulfiqar B, Iqbal R

824. The effect of long-range interactions on the infrared and Raman spectra of aragonite (CaCO(3), Pmcn) up to 25 GPa.

Sci Rep

2023 Feb 15

Ulian G, Valdrè G.

825. Characteristics of the cervical spine and cervical cord injuries in older adults with cervical ossification of the posterior longitudinal ligament.

Sci Rep

2023 Feb 15

Okuwaki S, Funayama T, Koda M

826. Iron oxide/hydroxide-nitrogen doped graphene-like visible-light active photocatalytic layers for antibiotics removal from wastewater.

Sci Rep

2023 Feb 15

Ivan R, Popescu C, Antohe VA

827. Dose-response of benazepril on biomarkers of the classical and alternative pathways of the renin-angiotensin-aldosterone system in dogs.

Sci Rep

2023 Feb 15

Sotillo S, Ward JL, Guillot E

828. Multi-dimensional safety risk assessment on coal mines under the profitability dilemma.

Sci Rep

2023 Feb 15

You Q, Yao Q, Song R

829. Fetal growth restriction followed by early catch-up growth impairs pancreatic islet morphology in male rats.

Sci Rep

2023 Feb 15

Jabary M(#), Onoda A(#), Kitase Y

830. Perceived social support in solo women seeking treatment with donor gametes and in women in heterosexual couples seeking IVF-treatment with own gametes.

Sci Rep

2023 Feb 15

Lindell Pettersson M, Sydsjö G, Lampic C

Solo motherhood is a family constellation that is becoming increasingly common in high income countries. The demographic characteristics of solo women entering treatment with donated sperm or embryo have been shown to be different from that of cohabiting women. The general importance of perceived social support is frequently amplified when health and quality of life are concerned, and positively affects mental health status, experienced stress, perceived self-efficacy during the transition to parenthood and during parenthood itself. The objective of the present study was to compare demographic characteristics, social network and perceived social support among solo women and cohabiting women awaiting fertility treatment. This objective was explored with a study-specific demographic and background questionnaire as well as through questions on access to practical support and the Multidimensional Scale of Perceived Social Support (MSPSS) assessing different sources of support. This study is a part of a longitudinal prospective multicenter study of solo women who awaited donation treatment in six Swedish public and private fertility clinics and a comparison group of women who were cohabiting/married to male partner and awaited in vitro fertilization (IVF) treatment with the couple's own gametes. A total of 670 women were invited and 463 accepted participation (69% response rate); 207 solo women (study group) and 256 cohabiting women (comparison group). The results show significant differences in age, education, and employment between the groups. Solo women were on average 3.6 years older, had a higher level of education, a higher-income profession, and were more frequently working full time. Solo women perceived an equally high degree of social support from their families, significantly higher levels of support from friends and significantly lower support from a significant other compared to cohabiting women. Solo women expected their mother to be the most supportive person in future parenthood, while cohabiting women most often stated their cohabiting partner to fill that role. The study adds to the body of knowledge of solo women as a sociodemographic distinct group going at motherhood alone, stating a high degree of currently perceived and expected social support. The previously studied negative impact that lack of a co-parent might have, may be attenuated by the expected and perceived social support from family and friends.

831. Developmental programming: adverse sexually dimorphic transcriptional programming of gestational testosterone excess in cardiac left ventricle of fetal sheep.

Sci Rep

2023 Feb 15

Ramamoorthi Elangovan V(#), Saadat N(#), Ghnenis A

832. Comparison of the efficacy of 0.5% isobaric bupivacaine, 0.5% levobupivacaine, and 0.5% hyperbaric bupivacaine for spinal anesthesia in lower limb surgeries.

Sci Rep

2023 Feb 15

Piacherski V, Muzyka L.

Various advantages of isobaric bupivacaine, levobupivacaine, and hyperbaric bupivacaine are described. There are no studies reliably determining the benefits of these forms of bupivacaine. The purpose of the study was to compare the efficacy of spinal anesthesia (SA) performed with 0.5% isobaric bupivacaine, 0.5% levobupivacaine, and 0.5% hyperbaric bupivacaine. The clinical study was approved by the ethics committee. The sample size was calculated for a confidence level of 99%. 111 patients were randomly allocated into 3 equal groups for spinal anesthesia in lower limb surgeries. In group 1 (1B) spinal anesthesia was performed with 3 ml of 0.5% isobaric bupivacaine (n = 37); in group 2 (2L)-3 ml of 0.5% levobupivacaine (n = 37), in group 3 (3H)-3 ml of 0.5% hyperbaric bupivacaine (n = 37). The criterion for assessing the effectiveness of anesthesia was the need to switch to another type of anesthesia (criterion-no anesthesia), or the need for additional use of narcotic analgesics or local anesthesia during surgery (criterion-reporting of painful feelings during the operation). In 1B anesthesia efficiency by the criterion of additional intraoperative analgesia was 100% (37 patients; 95% CI [0.88-1.0]); 2L-86.4%; (31 patients; 95% CI [0.68-0.92]); 3H-72.9% (27 patients; 95% CI [0.56-0.84]). There were significant differences between groups 1B and 2L: p < 0.05 (p = 0.0104). There were no significant differences between groups 2L and 3H (p = 0.2587). All patients in group 1B developed complete sensory block (++) within 4 (3; 5) min. In group 2L complete sensory block developed in 34 patients (89.4%) within 9 (5; 14) min, in group 3H sensory block developed in all patients within 3 (2.5; 4). The duration of analgesia period between 1B and 2L did not statistically differ (p = 0.73). In 3H the duration of analgesia was 170 (150; 200) min. The study found 83.7% efficacy of levobupivacaine and 72.9% efficacy of hyperbaric bupivacaine in comparison with isobaric bupivacaine (100%) when administered intrathecally in equal volumes and amounts (by the criterion of additional intraoperative analgesia).Trial registration: NCT05184465 (Initial Release: 12/01/2021; date of first publication-11/01/2022).

833. Livestock exposure to future cumulated climate-related stressors in West Africa.

Sci Rep

2023 Feb 15

Brouillet A, Sultan B.

834. Towards environmental detection, quantification, and molecular characterization of Anopheles stephensi and Aedes aegypti from experimental larval breeding sites.

Sci Rep

2023 Feb 15

Kristan M, Acford-Palmer H, Campos MO

835. Analysis of economic forecasting in the post-epidemic era: evidence from China.

Sci Rep

2023 Feb 15

Li X.

836. Nature-inspired stochastic hybrid technique for joint and individual inversion of DC and MT data.

Sci Rep

2023 Feb 15

Sarkar K, Mukesh, Singh UK.

Here, a new naturally-inspired stochastic nonlinear joint and individual inversion technique for integrating direct current (DC) and magnetotelluric (MT) data interpretation-based simulation of a swarm intelligence combo with specific capabilities for exploitation of the variable weight particle swarm optimizer (vPSO) and exploration of the grey wolf optimizer (GWO), vPSOGWO, is used. They are particularly notable for their capacity for information exchange while hunting for food. Through synthetic MT and DC data contaminated with various sets of random noise, the applicability of the anticipated vPSOGWO algorithm based joint and individual inversion algorithm was assessed. The field examples, collected from diversified different geological terrains, including Digha (West Bengal), India; Sundar Pahari (Jharkhand), India; Puga Valley (Ladakh), India; New Brunswick, Canada; and South Central Australia, have shown the practical application of the proposed algorithm. Further, a Bayesian probability density function (bpdf) for estimating a mean global model and uncertainty assessment in posterior; and a histogram for model resolution assessment have also been created using 1000 inverted models. We examined the inverted outcomes and compared them with results from other cutting-edge methodologies, including the GWO, PSO, genetic algorithm (GA), Levenberg-Marquardt (LM), and ridge-regression (RR). Our findings showed that the current methodology is more effective than the GWO, PSO, GA, LM, and RR techniques at consistently improving the convergence of the global minimum. In contrast to earlier approaches, the current cutting-edge strategy vPSOGWO offers an improved resolution of an additional significant crustal thickness of about 65.68 ± 1.96 km over the Puga Valley, in which the inverted crustal thickness determined by vPSOGWO agrees well with the published crustal thickness over the Puga Valley. The new technology brings simulations closer to genuine models by significantly reducing uncertainty and enhancing model resolution.

837. Early sleep after action observation and motor imagery training boosts improvements in manual dexterity.

Sci Rep

2023 Feb 14

Temporiti F(#), Calcagno A(#), Coelli S

838. Robustness of a multivariate composite score when evaluating distress of animal models for gastrointestinal diseases.

Sci Rep

2023 Feb 14

Talbot SR, Kumstel S, Schulz B

The fundament of an evidence-based severity assessment in laboratory animal science is reliable distress parameters. Many readouts are used to evaluate and determine animal distress and the severity of experimental procedures. Therefore, we analyzed four distinct parameters like the body weight, burrowing behavior, nesting, and distress score in the four gastrointestinal animal models (pancreatic ductal adenocarcinoma (PDA), pancreatitis, CCl4 intoxication, and bile duct ligation (BDL)). Further, we determined the parameters' robustness in various experimental subgroups due to slight variations like drug treatment or telemeter implantations. We used non-parametric bootstrapping to get robust estimates and 95% confidence intervals for the experimental groups. It was found that the performance of the readout parameters is model-dependent and that the distress score is prone to experimental variation. On the other hand, we also found that burrowing and nesting can be more robust than, e.g., the body weight when evaluating PDA. However, the body weight still was highly robust in BDL, pancreatitis, and CCl4 intoxication. To address the complex nature of the multi-dimensional severity space, we used the Relative Severity Assessment (RELSA) procedure to combine multiple distress parameters into a score and mapped the subgroups and models against a defined reference set obtained by telemeter implantation. This approach allowed us to compare the severity of individual animals in the experimental subgroups using the maximum achieved severity (RELSAmax). With this, the following order of severity was found for the animal models: CCl4 < PDA ≈ Pancreatitis < BDL. Furthermore, the robustness of the RELSA procedure and outcome was externally validated with a reference set from another laboratory also obtained from telemeter implantation. Since the RELSA procedure reflects the multi-dimensional severity information and is highly robust in estimating the quantitative severity within and between models, it can be deemed a valuable tool for laboratory animal severity assessment.

839. Adjusting time-of-day and depth of fishing provides an economically viable solution to seabird bycatch in an albacore tuna longline fishery.

Sci Rep

2023 Feb 14

Gilman E, Evans T, Pollard I

840. MSR1 is not required for obesity-associated inflammation and insulin resistance in mice.

Sci Rep

2023 Feb 14

Nance SA, Muir L, Delproprosto J

841. Clinical outcomes of colonoscopic polypectomy with strategic surveillance colonoscopies in patients with 10 or more polyps.

Sci Rep

2023 Feb 14

Park JH, Hong SW, Hwang SW

842. Performance of novice versus experienced surgeons for dental implant placement with freehand, static guided and dynamic navigation approaches.

Sci Rep

2023 Feb 14

Wang X, Shujaat S, Meeus J

843. Investigation of the inverse problem for the Arrhenius equation using the example of thermal degradation of spongin-based scaffolds.

Sci Rep

2023 Feb 14

Żółtowska S, Ciałkowski M, Alejski K

844. Cell quantification in digital contrast microscopy images with convolutional neural networks algorithm.

Sci Rep

2023 Feb 14

Ferreira EKGD, Lara DSD, Silveira GF.

845. Life cycle of the cold-water coral Caryophyllia huinayensis.

Sci Rep

2023 Feb 14

Heran T, Laudien J, Waller RG

846. Diagnosis of Fusarium oxysporum f. sp. ciceris causing Fusarium wilt of chickpea using loop-mediated isothermal amplification (LAMP) and conventional end-point PCR.

Sci Rep

2023 Feb 14

Achari SR, Mann RC, Sharma M

847. Voluntary running-induced activation of ventral hippocampal GABAergic interneurons contributes to exercise-induced hypoalgesia in neuropathic pain model mice.

Sci Rep

2023 Feb 14

Minami K, Kami K, Nishimura Y

848. Activity patterns are associated with fractional lifespan, memory, and gait speed in aged dogs.

Sci Rep

2023 Feb 14

Mondino A, Khan M, Case B

849. Graft rejection episodes after keratoplasty in Japanese eyes.

Sci Rep

2023 Feb 14

Wajima H, Hayashi T, Kobayashi A

850. Adaptive photoperiod interpretation modulates phenological timing in Atlantic salmon.

Sci Rep

2023 Feb 14

Oldham T, Oppedal F, Fjelldal PG

851. DUSP1 mediates BCG induced apoptosis and inflammatory response in THP-1 cells via MAPKs/NF-κB signaling pathway.

Sci Rep

2023 Feb 14

Liu Z(#), Wang J(#), Dai F

852. Itinerant-localized dichotomy in magnetic anisotropic properties of U-based ferromagnets.

Sci Rep

2023 Feb 14

Shick AB, Halevy I, Tchaplianka M

853. Modulation of transcription factor dynamics allows versatile information transmission.

Sci Rep

2023 Feb 14

Givré A, Colman-Lerner A, Ponce Dawson S.

854. Interpretable patent recommendation with knowledge graph and deep learning.

Sci Rep

2023 Feb 14

Chen H, Deng W.

855. Double bare metal stent deployment combined with intraductal radiofrequency ablation for malignant distal biliary obstruction: a prospective pilot study.

Sci Rep

2023 Feb 14

Inoue T, Ibusuki M, Kitano R

856. Association of p-phenylenediamine exposure with alterations of pulmonary function, pruritus and health-related quality of life in hair dye factory workers: a cross-sectional study.

Sci Rep

2023 Feb 14

Zhang M, Zhang M, Zeng Q

857. Standoff detection of bacterial spores by field deployable coherent Raman spectroscopy.

Sci Rep

2023 Feb 14

Coluccelli N, Galzerano G, Laporta P

858. Environmental variables and machine learning models to predict cetacean abundance in the Central-eastern Mediterranean Sea.

Sci Rep

2023 Feb 14

Maglietta R, Saccotelli L, Fanizza C

859. Identifying inhibitors of β-haematin formation with activity against chloroquine-resistant Plasmodium falciparum malaria parasites via virtual screening approaches.

Sci Rep

2023 Feb 14

Amod L, Mohunlal R, Teixeira N

860. Seismic performance analysis of shallow-buried large-scale three-box-section segment-connected pipeline structure under multiple actions.

Sci Rep

2023 Feb 14

Wang H, Chen Z, Ma S

861. Association of age and spinopelvic function in patients receiving a total hip arthroplasty.

Sci Rep

2023 Feb 14

Haffer H, Hu Z, Wang Z

Restricted spinopelvic mobility received attention as a contributing factor for total hip arthroplasty (THA) instability. However, it is still unknown, how the spinopelvic function is influenced by age. In identifying the patients at highest risk for altered spinopelvic mechanics the study aimed to determine the association of age on the individual segments of the spinopelvic complex and global spinal sagittal alignment in patients undergoing THA. 197 patients were included in the prospective observational study conducting biplanar stereoradiography (EOS) in standing and sitting position pre-and postoperatively. Two independent investigators assessed C7-sagittal vertical axis (C7-SVA), cervical lordosis (CL), thoracic kyphosis (TK), lumbar lordosis (LL), pelvic incidence (PI), sacral slope (SS), anterior plane pelvic tilt (APPT), and pelvic femoral angle (PFA). Key segments of the spinopelvic complex are defined as lumbar flexibility (∆ LL = LLstanding - LLsitting), pelvic mobility (∆ SS = SSstanding - SSsitting) and hip motion (∆ PFA = PFAstanding - PFAsitting). Pelvic mobility was further defined based on ∆ SS = SSstanding - SSsitting as stiff (∆ SS < 10°), normal (∆ SS ≥ 10°-30°) and hypermobile (∆ SS > 30°). The patient collective was classified into three groups: (1) < 60 years (n = 56), (2) ≥ 60-79 years (n = 112) and (3) ≥ 80 years (n = 29). Lumbar flexibility (∆ LL) was decreased with increasing age between all groups (36.1° vs. 23.1° vs. 17.2°/p1+2 < 0.000, p2+3 = 0.020, p1+3 < 0.000) postoperatively. Pelvic mobility (∆ SS) was decreased in the groups 2 and 3 compared to group 1 (21.0° and 17.9° vs. 27.8°/p1+2 < 0.000, p2+3 = 0.371, p1+3 = 0.001). Pelvic retroversion in standing position (APPT) was higher in group 2 and 3 compared to group 1 (1.9° and - 0.5° vs 6.9°/p1+2 < 0.000, p2+3 = 0.330, p1+3 < 0.000). Global sagittal spinal balance (C7-SVA) showed more imbalance in groups 2 and 3 compared to group 1 (60.4 mm and 71.2 mm vs. 34.5 mm/p1+2 < 0.000, p2+3 = 0.376, p1+3 < 0.000) postoperatively. The preoperative proportion of patients with stiff pelvic mobility in group 1 was distinctly lower than in group 3 (23.2% vs. 35.7%) and declined in group 1 to 1.8% compared to 20.7% in group 3 after THA. Changes after THA were reported for groups 1 and 2 representing spinopelvic complex key parameter lumbar flexibility (∆ LL), pelvic mobility (∆ SS) and hip motion (∆ PFA), but not for group 3. This is the first study to present age-adjusted normative values for spinopelvic mobility. The subgroups with increased age were identified as risk cohort for altered spinopelvic mechanics and enhanced sagittal spinal imbalance and limited capacity for improvement of mobility after THA. This valuable information serves to focus in the preoperative screening on the THA candidates with the highest risk for abnormal spinopelvic function.

862. Characterization of the influence of the dominant tract on hand closing post stroke based on the Fugl-Meyer score.

Sci Rep

2023 Feb 14

Baghi R(#), Kim D(#), Koh K

863. Magnetization dynamics at finite temperature in CoFeB-MgO based MTJs.

Sci Rep

2023 Feb 14

Sampan-A-Pai S, Phoomatna R, Boonruesi W

864. Hybrid autoencoder with orthogonal latent space for robust population structure inference.

Sci Rep

2023 Feb 14

Yuan M, Hoskens H, Goovaerts S

865. Symplectic superposition solutions for free in-plane vibration of orthotropic rectangular plates with general boundary conditions.

Sci Rep

2023 Feb 14

Hu Z, Du J, Liu M

866. Developmental exposure to domoic acid targets reticulospinal neurons and leads to aberrant myelination in the spinal cord.

Sci Rep

2023 Feb 14

Panlilio JM, Hammar KM, Aluru N

867. Donor cord blood aging accelerates in recipients after transplantation.

Sci Rep

2023 Feb 14

Onizuka M, Imanishi T, Harada K

868. Evaluation of synthesized biosurfactants as promising corrosion inhibitors and alternative antibacterial and antidermatophytes agents.

Sci Rep

2023 Feb 14

Fawzy A, Al Bahir A, Alqarni N

This study investigated different amino acid-based surfactants (AASs), also known as biosurfactants, including sodium N-dodecyl asparagine (AS), sodium N-dodecyl tryptophan (TS), and sodium N-dodecyl histidine (HS) for their potential anticorrosion, antibacterial, and antidermatophyte properties. The chemical and electrochemical techniques were employed to examine the copper corrosion inhibition efficacy in H2SO4 (1.0 M) solution at 298 K. The results indicated their promising corrosion inhibition efficiencies (% IEs), which varied with the biosurfactant structures and concentrations, and the concentrations of corrosive medium. Higher % IEs values were attributed to the surfactant adsorption on the copper surface and the production of a protective film. The adsorption was in agreement with Langmuir adsorption isotherm. The kinetics and mechanisms of copper corrosion and its inhibition by the examined AASs were illuminated. The surfactants behaved as mixed-kind inhibitors with minor anodic priority. The values of % IEs gained from weight loss technique at a 500 ppm of the tested surfactants were set to be 81, 83 and 88 for AS, HS and TS, respectively. The values of % IEs acquired from all the applied techniques were almost consistent which were increased in the order: TS > HS ≥ AS, establishing the validity of this study. These surfactants also exhibited strong broad-spectrum activities against pathogenic Gram-negative and Gram-positive bacteria and dermatophytes. HS exhibited the highest antimicrobial activity followed by TS, and AS. The sensitivity of pathogenic bacteria varied against tested AASs. Shigella dysenteriae and Trichophyton mantigrophytes were found to be the most sensitive pathogens. HS exhibited the highest antibacterial activity against Shigella dysenteriae, Bacillus cereus, E. coli, K. pneumoniae, and S. aureus through the formation of clear zones of 70, 50, 40, 39, and 35 mm diameters, respectively. AASs also exhibited strong antifungal activity against all the tested dermatophyte molds and fungi. HS caused the inhibition zones of 62, 57, 56, 48, and 36 mm diameters against Trichophyton mantigrophytes, Trichophyton rubrum, Candida albicans, Trichosporon cataneum, and Cryptococcus neoformans, respectively. AASs minimal lethal concentrations ranged between 16 to 128 µg/ml. HS presented the lowest value (16 µg/ml) against tested pathogens followed by TS (64 µg/ml), and AS (128 µg/ml). Therefore, AASs, especially HS, could serve as an effective alternative antimicrobial agent against food-borne pathogenic bacteria and skin infections-associated dermatophyte fungi.

869. Exploring the influence of personal factors on physiological responses to mental imagery in sport.

Sci Rep

2023 Feb 14

Budnik-Przybylska D, Syty P, Kaźmierczak M

870. Impact of gene alterations on clinical outcome in young adults with myelodysplastic syndromes.

Sci Rep

2023 Feb 14

Konishi T(#), Sadato D(#), Toya T

871. Pulmonary recovery from COVID-19 in patients with metabolic diseases: a longitudinal prospective cohort study.

Sci Rep

2023 Feb 14

Sonnweber T(#), Grubwieser P(#), Pizzini A

872. Enduring musician advantage among former musicians in prosodic pitch perception.

Sci Rep

2023 Feb 14

Toh XR, Tan SH, Wong G

873. Influence of surgical position and registration methods on clinical accuracy of navigation systems in brain tumor surgery.

Sci Rep

2023 Feb 14

Furuse M(#), Ikeda N(#), Kawabata S

874. Imaginary pills and open-label placebos can reduce test anxiety by means of placebo mechanisms.

Sci Rep

2023 Feb 14

Buergler S, Sezer D, Bagge N

875. Revealing Corynebacterium glutamicum proteoforms through top-down proteomics.

Sci Rep

2023 Feb 14

Melo RM, de Souza JMF, Williams TCR

876. Sequence dependent UV damage of complete pools of oligonucleotides.

Sci Rep

2023 Feb 14

Kufner CL, Krebs S, Fischaleck M

877. Geographical variability of bacterial communities of cryoconite holes of Andean glaciers.

Sci Rep

2023 Feb 14

Pittino F, Ambrosini R, Seeger M

878. Effects of concentration-dependent graphene on maize seedling development and soil nutrients.

Sci Rep

2023 Feb 14

Wang S, Liu Y, Wang X

The long-term use of chemical fertilizers to maintain agricultural production has had various harmful effects on farmland and has greatly impacted agriculture's sustainable expansion. Graphene, a unique and effective nanomaterial, is used in plant-soil applications to improve plant nutrient uptake, reduce chemical fertilizer pollution by relieving inadequate soil nutrient conditions and enhance soil absorption of nutrient components. We investigated the effects of graphene amendment on nutrient content, maize growth, and soil physicochemical parameters. In each treatment, 5 graphene concentration gradients (0, 25, 50, 100, and 150 g kg-1) were applied in 2 different types (single-layer and few-layers, SL and FL). Soil aggregates, soil accessible nutrients, soil enzyme activity, plant nutrients, plant height, stem diameter, dry weight, and fresh weight were all measured throughout the maize growth to the V3 stage. Compared to the control (0 g kg-1), we found that graphene increased the percentage of large agglomerates (0.25-10 mm) in the soil and significantly increased the geometric mean diameter (GMD) and mean weight diameter (MWD) values of > 0.25 mm water-stable agglomerates as the increase of concentration. Soil available nutrient content (AN, AP, and AK) increased, peaking at 150 g kg-1. Graphene boosted nutrient absorption by maize plants, and aboveground total nitrogen (TN), total phosphorus (TP), and total potassium (TK) contents rose with the increasing application, which raised aboveground fresh weight, dry weight, plant height, and stalk thickness. The findings above confirmed our prediction that adding graphene to the soil may improve maize plant biomass by enhancing soil fertility and improving the soil environment. Given the higher manufacturing cost of single-layer graphene and the greater effect of few-layer graphene on soil and maize plants at the same concentration, single-layer graphene and few-layer graphene at a concentration of 50 g kg-1 were the optimal application rates.

879. Use of the speckle imaging sub-pixel correlation analysis in revealing a mechanism of microbial colony growth.

Sci Rep

2023 Feb 14

Balmages I, Liepins J, Auzins ET

880. Usability of a mobile application for health professionals in home care services: a user-centered approach.

Sci Rep

2023 Feb 14

Manzano-Monfort G, Paluzie G, Díaz-Gegúndez M

881. Circular active noise barrier using theoretical control filter considering interaction between speaker and barrier.

Sci Rep

2023 Feb 14

Lee S, Park Y.

882. Impact of test, vaccinate or remove protocol on home ranges and nightly movements of badgers a medium density population.

Sci Rep

2023 Feb 14

Redpath SHA, Marks NJ, Menzies FD

In the British Isles, the European badger (Meles meles) is thought to be the primary wildlife reservoir of bovine tuberculosis (bTB), an endemic disease in cattle. Test, vaccinate or remove ('TVR') of bTB test-positive badgers, has been suggested to be a potentially useful protocol to reduce bTB incidence in cattle. However, the practice of removing or culling badgers is controversial both for ethical reasons and because there is no consistent observed effect on bTB levels in cattle. While removing badgers reduces population density, it may also result in disruption of their social behaviour, increase their ranging, and lead to greater intra- and inter-species bTB transmission. This effect has been recorded in high badger density areas, such as in southwest England. However, little is known about how TVR affects the behaviour and movement of badgers within a medium density population, such as those that occur in Northern Ireland (NI), which the current study aimed to examine. During 2014-2017, badger ranging behaviours were examined prior to and during a TVR protocol in NI. Nightly distances travelled by 38 individuals were determined using Global Positioning System (GPS) measurements of animal tracks and GPS-enhanced dead-reckoned tracks. The latter was calculated using GPS, tri-axial accelerometer and tri-axial magnetometer data loggers attached to animals. Home range and core home range size were measured using 95% and 50% autocorrelated kernel density estimates, respectively, based on location fixes. TVR was not associated with measured increases in either distances travelled per night (mean = 3.31 ± 2.64 km) or home range size (95% mean = 1.56 ± 0.62 km2, 50% mean = 0.39 ± 0.62 km2) over the four years of study. However, following trapping, mean distances travelled per night increased by up to 44% eight days post capture. Findings differ from those observed in higher density badger populations in England, in which badger ranging increased following culling. Whilst we did not assess behaviours of individual badgers, possible reasons why no differences in home range size were observed include higher inherent 'social fluidity' in Irish populations whereby movements are less restricted by habitat saturation and/or that the numbers removed did not reach a threshold that might induce increases in ranging behaviour. Nevertheless, short-term behavioural disruption from trapping was observed, which led to significant increases in the movements of individual animals within their home range. Whether or not TVR may alter badger behaviours remains to be seen, but it would be better to utilise solutions such as oral vaccination of badgers and/or cattle as well as increased biosecurity to limit bTB transmission, which may be less likely to cause interference and thereby reduce the likelihood of bTB transmission.

883. Muscle fat replacement and contractility in patients with skeletal muscle sodium channel disorders.

Sci Rep

2023 Feb 13

Pedersen JJ, Stemmerik MG, Jacobsen LN

884. Influence of Co doping on phase, structure and electrochemical properties of hydrothermally obtained Co(x)Zn(1-x)Fe(2)O(4) (x = 0.0-0.4) nanoparticles.

Sci Rep

2023 Feb 13

Putjuso T, Putjuso S, Karaphun A

885. Fermi liquid-like behaviour of cuprates in the pseudogap phase simulated via T-dependent electron-boson spectral density.

Sci Rep

2023 Feb 13

Park H, Hwang J.

886. Thioquinoline derivatives conjugated to thiosemicarbazide as potent tyrosinase inhibitors with anti-melanogenesis properties.

Sci Rep

2023 Feb 13

Noori M, Sabourian R, Tasharoie A

887. Gut microbiome composition associates with corticosteroid treatment, morbidity, and senescence in Chinook salmon (Oncorhynchus tshawytscha).

Sci Rep

2023 Feb 13

Couch CE, Neal WT, Herron CL

888. Static friction coefficient depends on the external pressure and block shape due to precursor slip.

Sci Rep

2023 Feb 13

Iwashita W, Matsukawa H, Otsuki M.

889. A hybrid multi-objective optimization of functional ink composition for aerosol jet 3D printing via mixture design and response surface methodology.

Sci Rep

2023 Feb 13

Zhang H, Liu Z, Yin S

890. Isotherm and kinetic studies of cadmium biosorption and its adsorption behaviour in multi-metals solution using dead and immobilized archaeal cells.

Sci Rep

2023 Feb 13

Hegazy GE, Soliman NA, Ossman ME

891. Volatile sulfide compounds and oral microorganisms on the inner surface of masks in individuals with halitosis during COVID-19 pandemic.

Sci Rep

2023 Feb 13

Lee YH, Kim H, Heo DW

Mask-wearing is still recommended owing to the continuing impact of the COVID-19 pandemic. Within the closed chamber created by the mask, people are increasingly self-aware of their oral malodor. In this prospective and cross-sectional study, we aimed to measure volatile sulfide compound (VSC) levels in patients with halitosis and investigate the oral microbiome profile on the inner surface of their KF94 masks. We also investigated which oral microbiota increases VSC levels and whether the oral microbiomes of oral saliva and mask are correlated. A total of 50 subjects (41 women, average age 38.12 ± 12.58 years old) were included in the study, 25 healthy subjects and 25 patients with halitosis who wore masks for more than 3 h. The dominant bacterial species, bacterial profile, and Shannon diversity index of whole unstimulated saliva and the inner surface of the mask were investigated. The bacterial 16S ribosomal RNA genes of the major oral bacterial species were analyzed using real-time PCR. Gas chromatography was used to measure hydrogen sulfide (H2S) and methyl mercaptan (CH3SH), which are representative VSCs. The total bacterial DNA copy number was significantly higher in the saliva sample than in the mask sample (p < 0.001), and the average value was 276 times greater. Shannon diversity index was also significantly higher in saliva than in the inner surface of the mask (2.62 ± 0.81 vs. 1.15 ± 1.52, p < 0.001). The most common Gram-negative and Gram-positive species in the masks were Porphyromonas gingivalis (Pg) and Lactobacillus casei (Lc), respectively. The bacterial species with significant positive correlations between saliva and mask samples were Prevotella intermedia (Pi) (r = 0.324, p = 0.022), Eikenella corrodens (r = 0.309, p = 0.029), Lc (r = 0.293, p = 0.039), and Parvimonas micra (Pm) (r = 0.366, p = 0.009). The mean value of CH3SH was significantly higher in the halitosis group than in the non-halitosis group (17.84 ± 29.00 vs. 3.84 ± 10.57 ppb, p = 0.031). In the halitosis group, the DNA copy numbers and VSC levels showed highly positive correlation coefficients in the order Pg, Treponema denticola (Td), Tannerella forsythia (Tf), Pi, and Prevotella nigrescens (Pn) (all p < 0.05). Regarding bacterial profiles of the mask, Td was strongly correlated with CH3SH (r = 0.414, p = 0.040) and total VSCs (r = 0.374, p = 0.033) only in halitosis group. Mask-wearing time was strongly correlated with total VSCs, H2S, and CH3SH (all r > 0.8, p < 0.001). Oral bacteria, whose association with halitosis has been identified, increased VSC levels in mask-wearing subjects during the COVID-19 pandemic, particularly the number of Gram-negative anaerobes such as Pg and Td. Mask-wearing time was a major factor in increasing VSC levels. The study results suggest that people with halitosis could control these Gram-negative bacteria by improving oral hygiene and regularly changing masks.

892. Activation of the rostral nucleus accumbens shell by optogenetics induces cataplexy-like behavior in orexin neuron-ablated mice.

Sci Rep

2023 Feb 13

Kawashima S, Lou F, Kusumoto-Yoshida I

893. Optimization of the hydrogen response characteristics of halogen-doped SnO(2).

Sci Rep

2023 Feb 13

Filippatos PP, Sharma R, Soultati A

894. Antioxidant enzymes that target hydrogen peroxide are conserved across the animal kingdom, from sponges to mammals.

Sci Rep

2023 Feb 13

Hewitt OH, Degnan SM.

895. Low frequency lattice mode dynamics of cyclotrimethylene trinitramine (RDX) crystal studied by femtosecond time-resolved impulsive stimulated Raman scattering.

Sci Rep

2023 Feb 13

Yu G, Song Y, Zhu G

896. Self-aligned multi-layer X-ray absorption grating using large-area fabrication methods for X-ray phase-contrast imaging.

Sci Rep

2023 Feb 13

Pil-Ali A, Adnani S, Karim KS.

X-ray phase-contrast (XPCi) imaging methods are an emerging medical imaging approach that provide significantly better soft tissue contrast and could function as a viable extension to conventional X-ray, CT, and even some MRI. Absorption gratings play a central role in grating-based XPCi systems, especially because they enable the acquisition of three images in a single exposure: transmission, refraction, and dark-field. An impediment to commercial development and adoption of XPCi imaging systems is the lack of large area, high aspect ratio absorption gratings. Grating technology development, primarily due to technological limitations, has lagged system development and today prevents the scaling up of XPCi system into a footprint and price point acceptable to the medical market. In this work, we report on a self-aligned multi-layer grating fabrication process that can enable large-area X-ray absorption gratings with micron-scale feature sizes. We leverage large-area fabrication techniques commonly employed by the thin-film transistor (TFT) display industry. Conventional ITO-on-glass substrates are used with a patterned film of Cr/Au/Cr that serves as a self-aligned lithography mask for backside exposure. Commonly available SU-8 photoresist is patterned using the backside exposure mask followed by an electroplating step to fill the gaps in the SU-8 with X-ray attenuating material. Consequently, the electroplated patterned material acts as a self-aligned photomask for subsequent SU-8 layer patterning and so forth. The repeatability of the reported process makes it suitable for achieving higher aspect ratio structures and is advantageous over previously reported X-ray LIGA approaches. A prototype three-layer grating, with a thickness of around [Formula: see text], having a visibility of 0.28 at [Formula: see text] with a [Formula: see text] active area was fabricated on a 4-inch glass substrate and demonstrated by modifying a commercially available 3D propagation-based XPCi Microscope. The scalable and cost-effective approach to build larger area X-ray gratings reported in this work can help expedite the commercial development and adoption of previously reported Talbot-Lau, speckle-tracking, as well as coded-aperture XPCi systems for large-area clinical and industrial applications.

897. Tanshinone IIA-loaded nanoparticles and neural stem cell combination therapy improves gut homeostasis and recovery in a pig ischemic stroke model.

Sci Rep

2023 Feb 13

Jeon JH, Kaiser EE, Waters ES

898. Acquisition of new function through gene duplication in the metallocarboxypeptidase family.

Sci Rep

2023 Feb 13

Fajardo D, Saint Jean R, Lyons PJ.

899. Ki67 increase after core needle biopsy associated with worse disease outcome in HER2-negative breast cancer patients.

Sci Rep

2023 Feb 13

Tong Y(#), Dai J(#), Huang J

900. House Sparrow (Passer domesticus) escape behavior is triggered faster in smaller settlements.

Sci Rep

2023 Feb 13

García-Arroyo M, MacGregor-Fors I, Quesada J

901. Precision dual-comb spectroscopy using wavelength-converted frequency combs with low repetition rates.

Sci Rep

2023 Feb 13

Sugiyama Y, Kashimura T, Kashimoto K

902. Multiple plasma membrane reporters discern LHFPL5 region that blocks trafficking to the plasma membrane.

Sci Rep

2023 Feb 13

Soler DC, Ballesteros A, Sloan AE

903. Diagnostic, clustering, and immune cell infiltration analysis of m6A regulators in patients with sepsis.

Sci Rep

2023 Feb 13

Li F(#), Zhang Y(#), Peng Z

904. A physics-informed neural network based on mixed data sampling for solving modified diffusion equations.

Sci Rep

2023 Feb 13

Fang Q(#), Mou X(#), Li S.

905. ATR-FTIR spectroscopy of plasma supported by multivariate analysis discriminates multiple sclerosis disease.

Sci Rep

2023 Feb 13

Crocco MC, Moyano MFH, Annesi F

906. Adélie penguins north and east of the 'Adélie gap' continue to thrive in the face of dramatic declines elsewhere in the Antarctic Peninsula region.

Sci Rep

2023 Feb 13

Wethington M, Flynn C, Borowicz A

907. Performance of classification and diagnostic criteria for IgG4-related disease and comparison of patients with and without IgG4-related disease.

Sci Rep

2023 Feb 13

Kogami M, Abe Y, Ando T

908. Using machine learning methods and EEG to discriminate aircraft pilot cognitive workload during flight.

Sci Rep

2023 Feb 13

Taheri Gorji H, Wilson N(#), VanBree J

Pilots of aircraft face varying degrees of cognitive workload even during normal flight operations. Periods of low cognitive workload may be followed by periods of high cognitive workload and vice versa. During such changing demands, there exists potential for increased error on behalf of the pilots due to periods of boredom or excessive cognitive task demand. To further understand cognitive workload in aviation, the present study involved collection of electroencephalogram (EEG) data from ten (10) collegiate aviation students in a live-flight environment in a single-engine aircraft. Each pilot possessed a Federal Aviation Administration (FAA) commercial pilot certificate and either FAA class I or class II medical certificate. Each pilot flew a standardized flight profile representing an average instrument flight training sequence. For data analysis, we used four main sub-bands of the recorded EEG signals: delta, theta, alpha, and beta. Power spectral density (PSD) and log energy entropy of each sub-band across 20 electrodes were computed and subjected to two feature selection algorithms (recursive feature elimination (RFE) and lasso cross-validation (LassoCV), and a stacking ensemble machine learning algorithm composed of support vector machine, random forest, and logistic regression. Also, hyperparameter optimization and tenfold cross-validation were used to improve the model performance, reliability, and generalization. The feature selection step resulted in 15 features that can be considered an indicator of pilots' cognitive workload states. Then these features were applied to the stacking ensemble algorithm, and the highest results were achieved using the selected features by the RFE algorithm with an accuracy of 91.67% (± 0.11), a precision of 93.89% (± 0.09), recall of 91.67% (± 0.11), F-score of 91.22% (± 0.12), and the mean ROC-AUC of 0.93 (± 0.06). The achieved results indicated that the combination of PSD and log energy entropy, along with well-designed machine learning algorithms, suggest the potential for the use of EEG to discriminate periods of the low, medium, and high workload to augment aircraft system design, including flight automation features to improve aviation safety.

909. Automatic measurement and prediction of Chinese Grown Pigs weight using multilayer perceptron neural networks.

Sci Rep

2023 Feb 13

Ositanwosu OE(#), Huang Q(#), Liang Y

910. The role of higher education and civic involvement in converting young adults' social responsibility to prosocial behavior.

Sci Rep

2023 Feb 13

Alfirević N, Arslanagić-Kalajdžić M, Lep Ž.

911. Political ideology and moral dilemmas in public good provision.

Sci Rep

2023 Feb 13

Hoenig LC, Pliskin R, De Dreu CKW.

912. Attention-assisted hybrid 1D CNN-BiLSTM model for predicting electric field induced by transcranial magnetic stimulation coil.

Sci Rep

2023 Feb 13

Sathi KA, Hosain MK, Hossain MA

913. Gender-specific association between serum ferritin and neurodevelopment in infants aged 6 to 12 months.

Sci Rep

2023 Feb 13

Guo Y, Yu L, Wu ZY

Early iron deficiency has detrimental consequences on neurodevelopment; whether male and female infants are equally susceptible to the functional outcomes of iron deficiency is unclear. This study aimed to investigate the sex differences in the association between serum ferritin levels and neurodevelopment in infants. Data for this cross-sectional study were drawn from hospital information and early childhood development program service systems at Guangdong Women and Children's Hospital, Guangzhou, China. In total, 4579 infants aged 6-12 months were included from July 2018 to March 2020. Their neurodevelopment was assessed using the Children Neuropsychological and Behavior Scale-Revision 2016. Serum ferritin levels were measured by chemiluminescence assay. The association between serum ferritin levels and neurodevelopmental delay in each domain was estimated using logistic regression models adjusted for potential confounders. The mean concentration of serum ferritin was 35.56 ± 21.57 ng/mL. Serum ferritin levels were significantly higher in female than in male infants (P < 0.001). Iron deficiency (serum ferritin levels < 12 ng/mL) was significantly more prevalent in male than in female infants (P < 0.001). Linear regression revealed a positive association between serum ferritin levels and general quotient, gross motor, fine motor, language, and adaptive behavior in females. Iron deficiency was significantly associated with an increased risk of adaptive behavior delay in females (adjusted odds ratio (OR), 2.22; 95% confidence interval (CI): 1.17-4.20). Iron deficiency anemia was associated with an increased risk of developmental delay for general quotient (adjusted OR, 4.88; 95% CI: 1.74-13.65), fine motor (adjusted OR = 2.58, 95%: CI: 1.13-5.94) and adaptive behavior (adjusted OR, 3.38; 95% CI: 1.51-7.57) among females, but not in males. Associations between serum ferritin levels and neurodevelopment in infants aged 6-12 months were sex-related. Females with iron deficiency, especially those with iron-deficiency anemia, were more susceptible to neurodevelopmental delay than males.

914. How scan parameter choice affects deep learning-based coronary artery disease assessment from computed tomography.

Sci Rep

2023 Feb 13

Denzinger F, Wels M, Breininger K

Recently, algorithms capable of assessing the severity of Coronary Artery Disease (CAD) in form of the Coronary Artery Disease-Reporting and Data System (CAD-RADS) grade from Coronary Computed Tomography Angiography (CCTA) scans using Deep Learning (DL) were proposed. Before considering to apply these algorithms in clinical practice, their robustness regarding different commonly used Computed Tomography (CT)-specific image formation parameters-including denoising strength, slab combination, and reconstruction kernel-needs to be evaluated. For this study, we reconstructed a data set of 500 patient CCTA scans under seven image formation parameter configurations. We select one default configuration and evaluate how varying individual parameters impacts the performance and stability of a typical algorithm for automated CAD assessment from CCTA. This algorithm consists of multiple preprocessing and a DL prediction step. We evaluate the influence of the parameter changes on the entire pipeline and additionally on only the DL step by propagating the centerline extraction results of the default configuration to all others. We consider the standard deviation of the CAD severity prediction grade difference between the default and variation configurations to assess the stability w.r.t. parameter changes. For the full pipeline we observe slight instability (± 0.226 CAD-RADS) for all variations. Predictions are more stable with centerlines propagated from the default to the variation configurations (± 0.122 CAD-RADS), especially for differing denoising strengths (± 0.046 CAD-RADS). However, stacking slabs with sharp boundaries instead of mixing slabs in overlapping regions (called true stack ± 0.313 CAD-RADS) and increasing the sharpness of the reconstruction kernel (± 0.150 CAD-RADS) leads to unstable predictions. Regarding the clinically relevant tasks of excluding CAD (called rule-out; AUC default 0.957, min 0.937) and excluding obstructive CAD (called hold-out; AUC default 0.971, min 0.964) the performance remains on a high level for all variations. Concluding, an influence of reconstruction parameters on the predictions is observed. Especially, scans reconstructed with the true stack parameter need to be treated with caution when using a DL-based method. Also, reconstruction kernels which are underrepresented in the training data increase the prediction uncertainty.

915. Increase in the wave power caused by decreasing sea ice over the Sea of Okhotsk in winter.

Sci Rep

2023 Feb 13

Iwasaki S.

916. A deep-learning approach for reconstructing 3D turbulent flows from 2D observation data.

Sci Rep

2023 Feb 13

Yousif MZ, Yu L, Hoyas S

917. Whole-genome sequencing-based analyses of drug-resistant Mycobacterium tuberculosis from Taiwan.

Sci Rep

2023 Feb 13

Xiao YX(#), Liu KH(#), Lin WH

918. Effect of contact vector direction on achieving cavotricuspid isthmus block.

Sci Rep

2023 Feb 13

Sumi H, Hoshiyama T, Morihisa K

919. The association between shift work and the incidence of reflux esophagitis in Korea: a cohort study.

Sci Rep

2023 Feb 13

Nam MW, Lee Y, Mun E

920. Factors associated with plasmid antibiotic resistance gene carriage revealed using large-scale multivariable analysis.

Sci Rep

2023 Feb 13

Orlek A, Anjum MF, Mather AE

921. Federated blockchain system (FBS) for the healthcare industry.

Sci Rep

2023 Feb 13

Mohey Eldin A, Hossny E, Wassif K

922. Effects of percutaneous transluminal angioplasty and associated factors in access hand oxygenation in patients undergoing hemodialysis.

Sci Rep

2023 Feb 13

Sugiyama T(#), Ito K(#), Ookawara S

923. Identification of novel targets and pathways to distinguish suicide dependent or independent on depression diagnosis.

Sci Rep

2023 Feb 13

Peng S, Zhou Y, Xiong L

In recent years, postmortem brain studies have revealed that some molecular, cellular, and circuit changes associated with suicide, have an independent or additive effect on depression. The aim of the present study is to identify potential phenotypic, tissue, and sex-specific novel targets and pathways to distinguish depression or suicide from major depressive disorder (MDD) comorbid with suicide. The mRNA expression profiling datasets from two previous independent postmortem brain studies of suicide and depression (GSE102556 and GSE101521) were retrieved from the GEO database. Machine learning analysis was used to differentiate three regrouped gene expression profiles, i.e., MDD with suicide, MDD without suicide, and suicide without depression. Weighted correlation network analysis (WGCNA) was further conducted to identify the key modules and hub genes significantly associated with each of these three sub-phenotypes. TissueEnrich approaches were used to find the essential brain tissues and the difference of tissue enriched genes between depression with or without suicide. Dysregulated gene expression cross two variables, including phenotypes and tissues, were determined by global analysis with Vegan. RRHO analysis was applied to examine the difference in global expression pattern between male and female groups. Using the optimized machine learning model, several ncRNAs and mRNAs with higher AUC and MeanDecreaseGini, including GCNT1P1 and AC092745.1, etc., were identified as potential molecular targets to distinguish suicide with, or without MDD and depression without suicide. WGCNA analysis identified some key modules significantly associated with these three phenotypes, and the gene biological functions of the key modules mainly relate to ncRNA and miRNA processing, as well as oxidoreductase and dehydrogenase activity. Hub genes such as RP11-349A22.5, C20orf196, MAPK8IP3 and RP11-697N18.2 were found in these key modules. TissueEnrich analysis showed that nucleus accumbens and subiculum were significantly changed among the 6 brain regions studied. Global analysis with Vegan and RRHO identified PRS26, ARNT and SYN3 as the most significantly differentially expressed genes across phenotype and tissues, and there was little overlap between the male and female groups. In this study, we have identified novel gene targets, as well as annotated functions of co-expression patterns and hub genes that are significantly distinctive between depression with suicide, depression without suicide, and suicide without depression. Moreover, global analysis across three phenotypes and tissues confirmed the evidence of sex difference in mood disorders.

924. Role of periosteum in alveolar bone regeneration comparing with collagen membrane in a buccal dehiscence model of dogs.

Sci Rep

2023 Feb 13

Ma Z(#), Guo K(#), Chen L

925. Persistent homology analysis distinguishes pathological bone microstructure in non-linear microscopy images.

Sci Rep

2023 Feb 13

Pritchard Y, Sharma A, Clarkin C

926. Global conservation prioritization areas in three dimensions of crocodilian diversity.

Sci Rep

2023 Feb 13

Lourenço-de-Moraes R, Campos FS, Cabral P

927. Prevalence, awareness, treatment, and control of hypertension and their risk factors in Shaanxi Province in 2004-18.

Sci Rep

2023 Feb 13

Wang W, Sa R, Dang S

928. Wheat husk-based sorbent as an economical solution for removal of oil spills from sea water.

Sci Rep

2023 Feb 13

Omar BM, Abdelgalil SA, Fakhry H

929. Structure-function assessment in glaucoma based on perimetric sensitivity and en face optical coherence tomography images of retinal nerve fiber bundles.

Sci Rep

2023 Feb 13

Alluwimi MS, Swanson WH, Malik R.

930. An extensive study on multiple ETL and HTL layers to design and simulation of high-performance lead-free CsSnCl(3)-based perovskite solar cells.

Sci Rep

2023 Feb 13

Hossain MK, Toki GFI, Kuddus A

Cesium tin chloride (CsSnCl3) is a potential and competitive absorber material for lead-free perovskite solar cells (PSCs). The full potential of CsSnCl3 not yet been realized owing to the possible challenges of defect-free device fabrication, non-optimized alignment of the electron transport layer (ETL), hole transport layer (HTL), and the favorable device configuration. In this work, we proposed several CsSnCl3-based solar cell (SC) configurations using one dimensional solar cell capacitance simulator (SCAPS-1D) with different competent ETLs like indium-gallium-zinc-oxide (IGZO), tin-dioxide (SnO2), tungsten disulfide (WS2), ceric dioxide (CeO2), titanium dioxide (TiO2), zinc oxide (ZnO), C60, PCBM, and HTLs of cuprous oxide (Cu2O), cupric oxide (CuO), nickel oxide (NiO), vanadium oxide (V2O5), copper iodide (CuI), CuSCN, CuSbS2, Spiro MeOTAD, CBTS, CFTS, P3HT, PEDOT:PSS. Simulation results revealed that ZnO, TiO2, IGZO, WS2, PCBM, and C60 ETLs-based halide perovskites with ITO/ETLs/CsSnCl3/CBTS/Au heterostructure exhibited outstanding photoconversion efficiency retaining nearest photovoltaic parameters values among 96 different configurations. Further, for the six best-performing configurations, the effect of the CsSnCl3 absorber and ETL thickness, series and shunt resistance, working temperature, impact of capacitance, Mott-Schottky, generation and recombination rate, current-voltage properties, and quantum efficiency on performance were assessed. We found that ETLs like TiO2, ZnO, and IGZO, with CBTS HTL can act as outstanding materials for the fabrication of CsSnCl3-based high efficiency (η ≥ 22%) heterojunction SCs with ITO/ETL/CsSnCl3/CBTS/Au structure. The simulation results obtained by the SCAPS-1D for the best six CsSnCl3-perovskites SC configurations were compared by the wxAMPS (widget provided analysis of microelectronic and photonic structures) tool for further validation. Furthermore, the structural, optical and electronic properties along with electron charge density, and Fermi surface of the CsSnCl3 perovskite absorber layer were computed and analyzed using first-principle calculations based on density functional theory. Thus, this in-depth simulation paves a constructive research avenue to fabricate cost-effective, high-efficiency, and lead-free CsSnCl3 perovskite-based high-performance SCs for a lead-free green and pollution-free environment.

931. Resistance training restores skeletal muscle atrophy and satellite cell content in an animal model of Alzheimer's disease.

Sci Rep

2023 Feb 13

Rahmati M, Shariatzadeh Joneydi M, Koyanagi A

932. Analysis of C-reactive protein from finger stick dried blood spot to predict high risk of cardiovascular disease.

Sci Rep

2023 Feb 13

Schakelaar MY, Kemperman H, Schoneveld AH

933. Wet oxidation and catalytic wet oxidation of pharmaceutical sludge.

Sci Rep

2023 Feb 13

Zeng X, Liu J, Zhao J.

934. Identification and validation of BCL6 and VEGFA as biomarkers and ageing patterns correlating with immune infiltrates in OA progression.

Sci Rep

2023 Feb 13

Chen Z(#), Wang W(#), Hua Y.

Osteoarthritis (OA), the most common type of arthritis, is a complex biological response caused by cartilage wear and synovial inflammation that links biomechanics and inflammation. The progression of OA correlates with a rise in the number of senescent cells in multiple joint tissues. However, the mechanisms by which senescent cells and their involvement with immune infiltration promote OA progression are not fully understood. The gene expression profiles and clinical information of OA and healthy control synovial tissue samples were retrieved from the Gene Expression Omnibus database, and then differential analysis of senescence regulators between OA and normal samples was performed. The random forest (RF) was used to screen candidate senescence regulators to predict the occurrence of OA. The reverse transcription quantitative real-time PCR experiments at tissue's level was performed to confirm these biomarkers. Moreover, two distinct senescence patterns were identified and systematic correlation between these senescence patterns and immune cell infiltration was analyzed. The senescence score and senescence gene clusters were constructed to quantify senescence patterns together with immune infiltration of individual OA patient. 73 senescence differentially expressed genes were identified between OA patients and normal controls. The RF method was utilized to build an OA risk model based on two senescence related genes: BCL6 and VEGFA. Next, two distinct aging patterns were determined in OA synovial samples. Most patients from senescence cluster A were further classified into gene cluster B and high senescence score group correlated with a non-inflamed phenotype, whereas senescence cluster B were classified into gene cluster A and low senescence score group correlated with an inflamed phenotype. Our study revealed that senescence played an important role in in OA synovial inflammation. Evaluating the senescence patterns of individuals with OA will contribute to enhancing our cognition of immune infiltration characterization, providing novel diagnostic and prognostic biomarkers, and guiding more effective immunotherapy strategies.

935. Microwave-assisted biodiesel production using bio-waste catalyst and process optimization using response surface methodology and kinetic study.

Sci Rep

2023 Feb 13

Devasan R, Ruatpuia JVL, Gouda SP

936. Ab-GALFA, A bioassay for insect gall formation using the model plant Arabidopsis thaliana.

Sci Rep

2023 Feb 13

Hirano T, Okamoto A, Oda Y

937. Weakly supervised semantic segmentation for MRI: exploring the advantages and disadvantages of class activation maps for biological image segmentation with soft boundaries.

Sci Rep

2023 Feb 13

Syed S, Anderssen KE, Stormo SK

938. Evaluating red tide effects on the West Florida Shelf using a spatiotemporal ecosystem modeling framework.

Sci Rep

2023 Feb 13

Vilas D, Buszowski J, Sagarese S

939. Synthesis of new magnetic nanocatalyst Fe(3)O(4)@CPTMO-phenylalanine-Ni and its catalytic effect in the preparation of substituted pyrazoles.

Sci Rep

2023 Feb 13

Bikas S, Poursattar Marjani A, Bibak S

940. Left ventricular hypertrophy detection using electrocardiographic signal.

Sci Rep

2023 Feb 13

Liu CW(#), Wu FH(#), Hu YL

941. Development and application of a new biological nano-selenium fermentation broth based on Bacillus subtilis SE201412.

Sci Rep

2023 Feb 13

Huang S(#), Yu K(#), Wen L

942. A machine learning pipeline to classify foetal heart rate deceleration with optimal feature set.

Sci Rep

2023 Feb 13

Das S, Obaidullah SM, Mahmud M

943. Gender differences in prevalence of hepatitis C virus infection in Egypt: a systematic review and meta-analysis.

Sci Rep

2023 Feb 13

Abdel-Gawad M, Nour M, El-Raey F

944. Detection of acute promyelocytic leukemia in peripheral blood and bone marrow with annotation-free deep learning.

Sci Rep

2023 Feb 13

Manescu P, Narayanan P, Bendkowski C

945. Effects of thinning on soil nutrient availability and fungal community composition in a plantation medium-aged pure forest of Picea koraiensis.

Sci Rep

2023 Feb 13

Caihong Z(#), Nier S(#), Hao W

Thinning is an important silvicultural practice for improving the productivity and wood production in plantation forest. Different intensities of thinning management can affect tree growth and alter soil nutrient effectiveness, thus affecting soil fungal community structure and diversity. Our objective is to determine the soil factors and their regulatory mechanisms that influence stand growth by thinning, and to provide data to support the establishment of large diameter timber cultivation technology for Picea koraiensis. In this study, we conducted medium- and high-intensity thinning in 43a P. koraiensis plantation middle-aged forests and investigated the growth indexes, soil physicochemical properties, and fungal community diversity in rhizosphere and non-rhizosphere soils of the stands after thinning at different densities (904 plants/ha for control, 644 plants/ha for 30% thinning intensity, and 477 plants/ha for 50% thinning intensity). The results showed that all growth indicators (annual growth of tree height, diameter at breast height, height under live branches and crown width) of the plantation after high-intensity thinning (477 plants/ha) were higher than those of the control (no thinning, significant) and medium-intensity thinning (644 plants/ha). Mycorrhizal infection rate was higher at the beginning of the growing season than at the end of the growing season, and increased slightly with decreasing stand density. Compared to the control, all medium- and high-intensity thinning treatments significantly improved soil nutrient content (P < 0.05), including total carbon, total nitrogen, total phosphorus, total potassium, Available phosphorus and Available potassium. Fungal diversity was higher but lower in abundance than the control in both rhizosphere and non-rhizosphere soils after thinning. The number of OTUs and fungal richness and diversity indices of non-rhizosphere soil fungi were higher than those of rhizosphere soil fungi. In conclusion, this study provides new evidence that reasonable intercalation can increase the radial and vertical growth of P. koraiensis plantation forests and promote the diversity of subsurface soil fungal communities. It is shown that thinning intensity regulates biogeochemical cycles in P. koraiensis plantation ecosystems by affecting soil nutrients and fungal community structure. Therefore, 50% thinning intensity can be used to increase timber production in plantation forests during large diameter timber cultivation of P. koraiensis and improve predictions associated with achieving long-term forest management strategies.

946. Protective effects of isorhamnetin against H(2)O(2)-induced oxidative damage in HaCaT cells and comprehensive analysis of key genes.

Sci Rep

2023 Feb 13

Hu W, Zhang J, Wang H

947. Asbestos exposure as an additional risk factor for small duct intrahepatic cholangiocarcinoma: a pilot study.

Sci Rep

2023 Feb 13

Vasuri F, Deserti M, Corradini AG

948. A validated LC-MS/MS method for clinical pharmacokinetics and presumptive phase II metabolic pathways following oral administration of Andrographis paniculata extract.

Sci Rep

2023 Feb 13

Songvut P, Pholphana N, Suriyo T

949. The combination of polyphenols and phospholipids as an efficient platform for delivery of natural products.

Sci Rep

2023 Feb 13

Hashemzadeh H, Hanafi-Bojd MY, Iranshahy M

Although nature is a rich source of potential drugs and drug leads, the widespread application of natural products (NPs) is limited due to their poor absorption when administered orally. A strategy of using phytosome has emerged as a promising technique to increase the bioavailability of NPs. Here, a comprehensive computational investigation is performed to explore the nature of interactions in the formation of phytosomes between phosphatidylcholine (PC) and a series of polyphenols (PP), including epigallocatechin-3-gallate (Eg), luteolin (Lu), quercetin (Qu), and resveratrol (Re). Our quantum mechanical calculation revealed that the intermolecular hydrogen bonds (HBs) of phosphate and glycerol parts of PC with the polyphenol compounds are the main driving force in the formation of phytosomes. The strongest HB (with energy HB = - 108.718 kJ/mol) is formed between the Eg molecule and PC. This hydrogen bond results from the flexible structure of the drug which along with several van der Waals (vdW) interactions, makes Eg-PC the most stable complex (adsorption energy = - 164.93 kJ/mol). Energy decomposition analysis confirms that the electrostatic interactions (hydrogen bond and dipole-diploe interactions) have a major contribution to the stabilization of the studied complexes. The obtained results from the molecular dynamics simulation revealed that the formation of phytosomes varies depending on the type of polyphenol. It is found that the intermolecular hydrogen bonds between PP and PC are a key factor in the behavior of the PP-PC complex in the self-aggregation of phytosome. In Eg-PC, Lu-PC, and Qu-PC systems, the formation of strong hydrogen bonds (HBCP < 0 and ∇2ρBCP > 0) between PP and PC protects the PP-PC complexes from degradation. The steered molecular dynamics simulation results have a good agreement with experimental data and confirm that the phytosome platform facilitates the penetration of PP compounds into the membrane cells.

950. Sunlight exposure cannot explain "grue" languages.

Sci Rep

2023 Feb 1

Hardy JL, Werner JS, Regier T

951. The graph structure of two-player games.

Sci Rep

2023 Feb 1

Biggar O, Shames I.

952. Tumor organoid biobank-new platform for medical research.

Sci Rep

2023 Feb 1

Xie X, Li X, Song W.

953. Analysis of vocal communication in the genus Falco.

Sci Rep

2023 Feb 1

Griffiths CS, Aaronson NL.

954. Spider mites avoid caterpillar traces to prevent intraguild predation.

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2023 Feb 1

Kinto S, Akino T, Yano S.

955. Appropriate screening mammography method for patients with breast implants.

Sci Rep

2023 Feb 1

Park J, Ko EY, Han BK

956. Investigation on the site of coronal deformities in Hallux valgus.

Sci Rep

2023 Feb 1

Wei RX, Ko VM, Chui EC

Hallux valgus (HV) is a common foot deformity that is more prevalent in females, characterised by abnormal adduction of the first metatarsal (MT) and valgus deviation of the phalanx on the transverse plane. Increasing evidence indicates that HV is more than a 2D deformity but a 3D one with rotational malalignment. Pronation deformity is seen during clinical examination for HV patients, but the exact origin of this rotational deformity is still unknown. Some attribute it to first tarsometatarsal (TMT) joint rotation, while others attribute it to intra-metatarsal bony torsion. In addition, the correlation between the rotational and transverse plane deformity is inconclusive. Identifying the origin of the rotational deformity will help surgeons choose the optimal surgical procedure while also enhancing our understanding of the pathophysiology of HV. This study aims to (1) develop an objective method for measuring the first MT torsion and first TMT joint rotation; (2) investigate the exact location of the coronal deformity in HV; (3) investigate the relationship between the severity of deformity on the transverse and coronal planes as well as the correlation between deformity severity and foot function/symptoms in HV. Age-matched females with and without HV were recruited at the Foot and Ankle Clinic of the Department of Orthopaedics and Traumatology. Computed tomography was conducted for all subjects with additional weight-bearing dorsal-plantar X-ray examination for HV subjects. Demographic information of all subjects was recorded, with symptoms and functions related to HV evaluated. The intra-class correlation was used to explore the relationship between deformities on different planes and the deformity severity and functional outcomes, respectively. An Independent t-test was used to compare joint rotation and bone torsion degrees. TMT joint rotation is significantly correlated with foot function. HV patients had more TMT joint rotation but not MT torsion compared to normal controls. No relationship was found between the coronal rotation and the 1,2-intermetatarsal angle (IMA) or Hallux valgus angle (HVA) on the transverse plane. Our results indicate that coronal deformities in HV may originate from TMT joint rotation. In addition, the severity of the TMT joint coronal rotation correlates with worse foot function; thus, multi-plane assessment and examination will be necessary for more precise surgical correction.

957. The effect of obesity on chronic diseases in USA: a flexible copula approach.

Sci Rep

2023 Feb 1

Dettoni R, Bahamondes C, Yevenes C

958. Effect of duodenal-jejunal bypass on diabetes in the early postoperative period.

Sci Rep

2023 Feb 1

Okikawa S, Kashihara H, Shimada M

959. Data-driven audiogram classifier using data normalization and multi-stage feature selection.

Sci Rep

2023 Feb 1

Elkhouly A, Andrew AM, Rahim HA

960. Majority networks and local consensus algorithm.

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2023 Feb 1

Goles E(#), Medina P(#), Santiváñez J(#).

961. Facile fabrication of a novel self-healing and flame-retardant hydrogel/MXene coating for wood.

Sci Rep

2023 Feb 1

Zhao X(#), Tian M(#), Wei R

962. Diagnostic accuracy of the Enferplex Bovine Tuberculosis antibody test in cattle sera.

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2023 Feb 1

O'Brien A, Clarke J, Hayton A

963. Lack of GPR180 ameliorates hepatic lipid depot via downregulation of mTORC1 signaling.

Sci Rep

2023 Feb 1

Yoshida K, Yokota K, Watanabe K

964. Method for 3D atomic structure determination of multi-element nanoparticles with graphene liquid-cell TEM.

Sci Rep

2023 Feb 1

Heo J(#), Kim D(#), Choi H(#)

965. A novel hybrid methodology to secure GOOSE messages against cyberattacks in smart grids.

Sci Rep

2023 Feb 1

Hussain S, Iqbal A, Hussain SMS

966. Identification of key immune-related genes in dilated cardiomyopathy using bioinformatics analysis.

Sci Rep

2023 Feb 1

Li F(#), Du TY(#), Wu LD(#)

967. Bioconversion of 4-hydroxyestradiol by extradiol ring-cleavage dioxygenases from Novosphingobium sp. PP1Y.

Sci Rep

2023 Feb 1

Mensitieri F, Bosso A, Dal Piaz F

968. Surface-dependent quenching of Qdot emission can be a new tool for high resolution measurements.

Sci Rep

2023 Feb 1

Okura K, Tatsumi H.

969. Oxygenated hemoglobin as prognostic marker among patients with systemic sclerosis screened for pulmonary hypertension.

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2023 Feb 1

Xanthouli P, Gordjani O, Benjamin N

970. Prevalence of early and late menopause and its determinants in Rafsanjan cohort study.

Sci Rep

2023 Feb 1

Vatankhah H, Khalili P, Vatanparast M

971. Modeling the impact of national and regional lockdowns on the 2020 spring wave of COVID-19 in France.

Sci Rep

2023 Feb 1

Roux J, Massonnaud CR, Colizza V

972. Non-invasive screening of breast cancer from fingertip smears-a proof of concept study.

Sci Rep

2023 Feb 1

Russo C, Wyld L, Da Costa Aubreu M

973. Disease severity classification using passively collected smartphone-based keystroke dynamics within multiple sclerosis.

Sci Rep

2023 Feb 1

Hoeijmakers A, Licitra G, Meijer K

974. Identification of key genes related to immune infiltration in cirrhosis via bioinformatics analysis.

Sci Rep

2023 Feb 1

Du TY, Gao YX, Zheng YS.

975. Association between low handgrip strength and obesity with mortality in peritoneal dialysis patients.

Sci Rep

2023 Feb 1

Do JY, Kang SH.

976. Vedolizumab is superior to infliximab in biologic naïve patients with ulcerative colitis.

Sci Rep

2023 Feb 1

Sablich R, Urbano MT, Scarpa M

There are no prospective, head-to-head, controlled trials comparing the efficacy and safety of Infliximab (IFX) and Vedolizumab (VDZ) for the treatment of moderate-to-severe ulcerative colitis (UC), while only a few real-life retrospective studies have been published so far. We assessed the efficacy of IFX vs. VDZ in two cohorts of biologic-naïve outpatients with moderate-to-severe UC or mild, but refractory, disease. Data were extracted from patients' files and reviewed. The duration of follow-up (FU) was 52 weeks. The primary endpoint was the clinical remission (CR) at the end of FU. Secondary endpoints were: drug persistency, time to obtain CR, clinical response at the end of the induction phase (IP), steroid-free CR (compared to patients who used steroids at baseline) at the end of FU, need for drug optimization, adverse events (AEs), and normalization of C-reactive protein (CRP). We also analyzed the causes of dropping out (primary non-response), or secondary loss of response (immunogenic or not), for each group. We enrolled 82 patients (50 IFX and 32 VDZ) who met the inclusion criteria. At the end of FU, CR was obtained in 32% of the patients on IFX and 75% on VDZ (p = 0.0003). Drug persistency was superior for VDZ compared to IFX (78% vs. 52%, p = 0.033). Clinical response at the end of induction was reached in 54% and in 81% in the IFX and VDZ group, respectively (p = 0.014). Steroid-free clinical remission at the end of FU was 62% and 94% in the IFX vs. VDZ group, respectively (p = 0.036). The need for drug optimization was higher for VDZ than for IFX (28% vs. 57%, p = 0.009), while the time to obtain CR, the incidence of AEs, mean duration of FU, and rate of CRP normalization at the end of IP were comparable between the two groups. There was a prevalence of patients dropping out because of primary non-response in IFX group (p = 0.027), while the incidence of secondary loss of response was similar in the two groups. At the multivariate analysis, CRP and Partial Mayo Score (PMS) at T0 did not correlate with CR at the end of FU in both groups. In this retrospective, real world data study in biologic-naïve patients, VDZ was superior to IFX in CR, clinical response rate at the end of IP, drug persistency, steroid-free remission, and need for optimization at the end of FU.

977. NHANES cross sectional study of aspirin and fractures in the elderly.

Sci Rep

2023 Feb 1

Swed S, El-Sakka AA, Abouainain Y

Bone fractures are a global public health concern, yet no thorough investigation of low-dose aspirin usage to prevent fractures in the elderly has been conducted. Many interventional human and animal studies have tried to detect the correct role of low-dose aspirin on fractures in elderly persons. The literature doesn't consist of a retrospective observational study that includes a large number of older individuals and evaluates the accurate effect of aspirin on the fractures post falling from low heights. This cross-sectional includes 7132 elderly persons and aimed to detect if there was a link between taking low-dose aspirin to prevent fractures in the elderly. Data was extracted from the National Health and Nutrition Examination Survey (NHANES) database for 2017-2020 and 2013-2014. Demographic and examination data were collected during in-home interviews and study visits to a mobile examination center. Standardized questionnaires were used to collect information such as age, gender, race, educational level, and family income-to-poverty ratio. Body mass index (BMI), weight, standing height, upper leg length, upper arm length, arm circumference, and wrist circumference were all measured during the examination. The study examined 8127 patients, with 7132 elderly patients suitable for data analysis. The odds ratio of fractures due to a fall from standing height or less was 0.963 (95 percent confidence interval 0.08-1.149) in low-dose aspirin users, while having parents with osteoporosis had a related risk of 1.23. (95 percent confidence interval 0.81-1.8). The total number of fractures was 1295; with hip fractures constituting up to 13.82%, wrist fractures of 66.56%, and spine fractures of 19.61%. There was no significant difference in femur and spine bone mineral density (BMD) in the two groups (use low dose aspirin and don't use). Females had a 5.6 times greater fracture risk related to a fall from standing height or less (1 time or more) than males (P-value < 0.001). Furthermore, taking aspirin had no effect on the occurrence of fractures from standing height or less in older people (P-value = 0.468). In addition, the logistic regression after performing the propensity matching score confirmed that there was no impact of taking aspirin on the occurrence of fractures (P-value > 0.05). This cross-sectional study reveals that taking low-dose aspirin to prevent fractures in the elderly is statistically insignificant. However, fractures are more common in older persons, especially in older women; thus, more widespread injury prevention initiatives and access to osteoporosis prevention and diagnosis for older people should improve to minimize the overall burden.

978. HIF-PHD inhibitor regulates the function of group2 innate lymphoid cells and polarization of M2 macrophages.

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2023 Feb 1

Nagashima R, Ishikawa H, Kuno Y

979. Physical evidence of meminductance in a passive, two-terminal circuit element.

Sci Rep

2023 Feb 1

Dinavahi A, Yamamoto A, Harris HR.

980. Prediction model for the compressive strength of green concrete using cement kiln dust and fly ash.

Sci Rep

2023 Feb 1

Bakhoum ES, Amir A, Osama F

981. Tamarixia radiata global distribution to current and future climate using the climate change experiment (CLIMEX) model.

Sci Rep

2023 Feb 1

Souza PGC, Aidoo OF, Farnezi PKB

982. Genetic algorithm optimization of broadband operation in a noise-like pulse fiber laser.

Sci Rep

2023 Feb 1

Lapre C, Meng F, Hary M

983. Whole-genome sequencing identifies potential candidate genes for egg production traits in laying ducks (Anas platyrhynchos).

Sci Rep

2023 Feb 1

Sun Y(#), Zhang Y(#), Wu Q

984. Effects of medwakh smoking on salivary metabolomics and its association with altered oral redox homeostasis among youth.

Sci Rep

2023 Feb 1

Aghila Rani KG(#), Soares NC(#), Rahman B

985. Monitoring storm evolution using a high-density seismic network.

Sci Rep

2023 Feb 1

Diaz J, Ruiz M, Udina M

Data acquired by a dense seismic network deployed in the Cerdanya basin (Eastern Pyrenees) is used to track the temporal and spatial evolution of meteorological events such as rainfall episodes or thunderstorms. Comparing seismic and meteorological data, we show that for frequencies above 40 Hz, the dominant source of seismic noise is rainfall and hence the amplitude of the seismic data can be used as a proxy of rainfall. The interstation distance of 1.5 km provides an unprecedented spatial resolution of the evolution of rainfall episodes along the basin. Two specific episodes, one dominated by stratiform rain and the second one dominated by convective rain, are analyzed in detail, using high resolution disdrometer data from a meteorological site near one of the seismic instruments. Seismic amplitude variations follow a similar evolution to radar reflectivity values, but in some stratiform precipitation cases, it differs from the radar-derived precipitation estimates in this region of abrupt topography, where radar may suffer antenna beam blockage. Hence, we demonstrate the added value of seismic data to complement other sources of information such as rain-gauge or weather radar observations to describe the evolution of ground-level rainfall fields at high spatial and temporal resolution. The seismic power and the rainfall intensity have an exponential relationship and the periods with larger seismic power are coincident. The time intervals with rain drops diameters exceeding 3.5 mm do not result in increased seismic amplitudes, suggesting that there is a threshold value from which seismic data are no longer proportional to the size of the drops. Thunderstorms can be identified by the recording of the sonic waves generated by thunders, with. Single thunders detected to distances of a few tens of kilometers. As the propagation of these acoustic waves is expected to be strongly affected by parameters as air humidity, temperature variations or wind, the seismic data could provide an excellent tool to investigate atmospheric properties variations during thunderstorms.

986. Comparison of radiological characteristics between diffuse idiopathic skeletal hyperostosis and ankylosing spondylitis: a multicenter study.

Sci Rep

2023 Feb 1

Takahashi T, Yoshii T, Mori K

987. Life time use of illicit substances among adolescents and young people hospitalized in psychiatric hospital.

Sci Rep

2023 Feb 1

Engelgardt P, Krzyżanowski M, Borkowska-Sztachańska M

Adolescents are known to be particularly vulnerable, compared to children and adults, to initiation of substance use and progression to problematic use. This study aimed to examine the prevalence and type of illicit drug use in a population of adolescents and young adults who were hospitalized in a psychiatric hospital. The purpose of the study was also to find the link between age, sex, type of admission and particular mental disorders and using psychoactive substances at least once in a lifetime. A 12-month retrospective cross-sectional analysis of medical records compiled for adolescent and youth psychiatric patients who had been admitted to the Regional Psychiatric Hospital in Olsztyn, Poland, between October 1, 2018, and September 30, 2019, was conducted. After analyzing the available medical records, 506 cases were included and analyzed. Data for the study were collected in an Excel spreadsheet from discharge reports, including data from psychiatric examinations, especially anamnesis. Subsequently, statistical calculations were performed. Lifetime prevalence of any illicit substance use (34.0%) was common. The most frequently used drug was Cannabis (29.2%), the next New Psychoactive Substance-NPS (14.2%) and Amphetamine (13.0%). The higher number of people declaring to take illicit substances was proportional to the increasing age. Except for the group 10-15 years, the subject group was dominated by males. The highest, statistically significant percentage of patients who declared taking illicit substances in general, was found in people with diagnoses F20-F29 (schizophrenia, schizotypal and delusional disorders) (55%), additionally, we found a statistically significant association between NPS use and these diagnoses. Only in the group of patients diagnosed with eating disorders no one declared taking psychoactive substances. However, the correlation between taking illicit drugs and the subgroups with diagnosed psychiatric diseases should be treated with caution because of the small sample size in some cases. Our findings have shown the significant prevalence of the phenomenon in this population. These data highlight the need to explore this population at high risk carefully.

988. Accuracy and feasibility of a novel fine hand motor skill assessment using computer vision object tracking.

Sci Rep

2023 Feb 1

Kim B, Neville C.

989. Alternate day versus daily oral iron for treatment of iron deficiency anemia: a randomized controlled trial.

Sci Rep

2023 Feb 1

Pasupathy E, Kandasamy R, Thomas K

990. Comparison of the combined use of CNV-seq and karyotyping or QF-PCR in prenatal diagnosis: a retrospective study.

Sci Rep

2023 Feb 1

Zhang H, Xu Z, Chen Q

991. In silico protein engineering shows that novel mutations affecting NAD(+) binding sites may improve phosphite dehydrogenase stability and activity.

Sci Rep

2023 Feb 1

Baammi S, Daoud R, El Allali A.

992. Synthesis of new diphenyl urea-clubbed imine analogs and its Implications in diabetic management through in vitro and in silico approaches.

Sci Rep

2023 Feb 1

Pasha AR, Khan A, Ullah S

993. Co-infection by multiple vector-borne agents in wild ring-tailed coatis (Nasua nasua) from Iguaçu National Park, southern Brazil.

Sci Rep

2023 Feb 1

Perles L, Moraes MF, Xavier da Silva M

994. Efficacy of combined transbronchial lung cryobiopsy and conventional forceps biopsy for lung malignancies: a prospective cohort study.

Sci Rep

2023 Feb 1

Kinoshita K, Morikawa K, Tsuruoka H

995. Toxic Ag(+) detection based on Au@Ag core shell nanostructure formation using Tannic acid assisted synthesis of Pullulan stabilized gold nanoparticles.

Sci Rep

2023 Feb 1

Jayeoye TJ, Supachettapun C, Muangsin N.

996. Detection of Babesia bovis using loop-mediated isothermal amplification (LAMP) with improved thermostability, sensitivity and alternative visualization methods.

Sci Rep

2023 Feb 1

Arnuphapprasert A, Nugraheni YR, Aung A

997. Cell type specific IL-27p28 (IL-30) deletion in mice uncovers an unexpected regulatory function of IL-30 in autoimmune inflammation.

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2023 Feb 1

Kim D, Kim S, Kang MS

998. Early warm compress treatment can promote recanalization of vascular embolisms and reduce tissue necrosis after polymethyl methacrylate injection.

Sci Rep

2023 Feb 1

Sun Y(#), Jin M(#), Wang G

999. Endoplasmic reticulum stress inhibition ameliorated WFS1 expression alterations and reduced pancreatic islets' insulin secretion induced by high-fat diet in rats.

Sci Rep

2023 Feb 1

Binayi F, Fahanik-Babaei J, Salimi M

1000. A multinational empirical study of perceived cyber barriers to automated vehicles deployment.

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2023 Feb 1

Khan SK, Shiwakoti N, Stasinopoulos P

1001. Effects of probiotic and synbiotic supplementation on ponderal and linear growth in severely malnourished young infants in a randomized clinical trial.

Sci Rep

2023 Feb 1

Nuzhat S, Hasan SMT, Palit P

1002. Peristaltic transport of Rabinowitsch nanofluid with moving microorganisms.

Sci Rep

2023 Feb 1

Moatimid GM, Mohamed MAA, Elagamy K.

The key objective of the current examination is to examine a symmetrically peristaltic movement of microorganisms in a Rabinowitsch fluid (RF). The Boussinesq approximation, buoyancy-driven flow, where the density with gravity force term is taken as a linear function of heat and concentrations, is kept in mind. The flow moves with thermophoretic particle deposition in a horizontal tube with peristalsis. The heat distribution and volume concentration are revealed by temperature radiation and chemical reaction characteristics. The originality of the existing study arises from the importance of realizing the benefits or the threats that nanoparticles, microbes, and bacteria cause in the flow inside peristaltic tubes. The results are an attempt to understand what factors perform additional advantages and or reduce damages. The controlling nonlinear partial differential equations (PDEs) are made simpler by employing the long wavelength (LWL) and low-Reynolds numeral (LRN) approximations. These equations are subjected to a set of non-dimensional transformations that result in a collection of nonlinear ordinary differential equations (ODEs). By employing the Homotopy perturbation method (HPM), the configuration of equational analytical solutions is examined. Analytical and graphical descriptions are provided for the distributions of axial speed, heat, microbes, and nanoparticles under the influence of these physical characteristics. The important findings of the current work may help to comprehend the properties of several variations in numerous biological situations. It is found that the microorganisms condensation decays with the rise of all the operational parameters. This means that the development of all these factors benefits in shrinking the existence of harmful microbes, viruses, and bacteria in the human body's peristaltic tubes, especially in the digestive system, and large and small intestines.

1003. Observation of plasma inflows in laser-produced Sn plasma and their contribution to extreme-ultraviolet light output enhancement.

Sci Rep

2023 Feb 1

Tomita K, Pan Y, Sunahara A

1004. Bagarius bagarius, and Eichhornia crassipes are suitable bioindicators of heavy metal pollution, toxicity, and risk assessment.

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2023 Feb 1

Mahamood M, Khan FR, Zahir F

1005. Zeolite A powder and beads from sugarcane bagasse fly ash modified with iron(III) oxide-hydroxide for lead adsorption.

Sci Rep

2023 Feb 1

Praipipat P, Ngamsurach P, Roopkhan N.

The discharging of lead-contaminated wastewater is a concern because of its toxicity to living organisms and water quality resulting in dangerous water consumption, so it is highly recommended to remove lead from wastewater to be below water quality standards for a safe environment. Zeolite A sugarcane bagasse fly ash powder (ZB), zeolite A sugarcane bagasse fly ash powder mixed iron(III) oxide-hydroxide (ZBF), zeolite A sugarcane bagasse fly ash beads (ZBB), zeolite A sugarcane bagasse fly ash powder mixed iron(III) oxide-hydroxide beads (ZBFB), and zeolite A sugarcane bagasse fly ash beads coated iron(III) oxide-hydroxide (ZBBF) were synthesized and characterized in various techniques. Their lead removal efficiencies were investigated by batch experiments, adsorption isotherms, and kinetics. The specific surface area, pore volume, and pore size of ZB were close values to zeolite A standard (STD), and ZBF had the highest specific surface area and the smallest pore size than others. ZB and ZBF demonstrated crystalline phases whereas ZBB, ZBFB, and ZBBF were amorphous phases. The surface morphology of ZB was a cubic shape similar to STD. ZBF demonstrated an agglomerated formation of ZB and iron(III) oxide-hydroxide whereas ZBFB and ZBBF had sphere shapes with coarse surfaces. Si, Al, O, Fe, Na, Ca, O-H, (Si, Al)-O, H2O, and D4R were detected in all materials. The surface charges of all zeolite A materials had negatively charged at all pH values, and their surfaces increased more negatively charged with increasing pH value which pH 5 illustrated as the highest negatively charged in all materials. Their lead removal efficiencies were higher than 82%. Langmuir isotherm and pseudo-second-order kinetic models were well explained for their adsorption patterns and mechanisms. Finally, ZBBF is a good offer for applying in industrial wastewater treatment systems because of its easy operation and saving costs than ZBF.

1006. Simultaneous determination of volatile phenol, cyanide, anionic surfactant, and ammonia nitrogen in drinking water by a continuous flow analyzer.

Sci Rep

2023 Feb 1

Qin G, Zou K, He F

This study developed a method for the simultaneous determination of volatile phenol, cyanide, anionic surfactant, and ammonia nitrogen in drinking water, using a continuous flow analyzer. The samples were first distilled at 145 °C. The phenol in the distillate then subsequently reacted with alkaline ferricyanide and 4-aminoantipyrine to form a red complex that was measured colorimetrically at 505 nm. Cyanide in the distillate subsequently reacted with chloramine T to form cyanogen chloride, which then formed a blue complex with pyridinecarboxylic acid that was measured colorimetrically at 630 nm. The anionic surfactant reacted with basic methylene blue to form a compound that was extracted into chloroform and washed with acidic methylene blue to remove interfering substances. The blue compound in chloroform was determined colorimetrically at 660 nm. Ammonia reacted with salicylate and chlorine from dichloroisocyanuric acid to produce indophenol blue at 37 °C in an alkaline environment that was measured at 660 nm. The relative standard deviations were 0.75-6.10% and 0.36-5.41%, respectively, and the recoveries were 96.2-103.6% and 96.0-102.4% when the mass concentration of volatile phenol and cyanide was in the range of 2-100 μg/L. The linear correlation coefficients were ≥ 0.9999, and the detection limits were1.2 μg/L and 0.9 μg/L, respectively. The relative standard deviations were 0.27-4.86% and 0.33-5.39%, and the recoveries were 93.7-107.0% and 94.4-101.7%. When the mass concentration of anionic surfactant and ammonia nitrogen was 10-1000 μg/L. The linear correlation coefficients were 0.9995 and 0.9999, and the detection limits were 10.7 μg/L and 7.3 μg/L, respectively. When compared to the national standard method, no statistically significant difference was found. This approach saves time and labor, has a lower detection limit, higher precision and accuracy, less contamination, and is more appropriate for the analysis and determination of large-volume samples.

1007. Modelling evolution of a large, glacier-fed lake in the Western Indian Himalaya.

Sci Rep

2023 Feb 1

Gantayat P, Ramsankaran R.

Newmer生物

Newmer生物