生信网-文献期刊

Sci Rep

2022 May 9

Gela YY, Fekadu SA, Belsti Y

Cognitive impairment and dementia are age-related major public health concerns in the elderly population. It is a major cause of disability, dependency, and poor quality of life. However, in Ethiopia, the magnitude of this cognitive impairment among the elderly community was not investigated. Hence, this study sought to determine the prevalence of cognitive impairment and associated factors among mature and older adults living in the community of Gondar town, Ethiopia, in 2020. A community-based cross-sectional study was conducted at Gondar town, from February 20 to April 30, 2020. Using a single-stage cluster sampling technique, 403 study participants were recruited. Data was collected by a pretested interviewer-administered structured questionnaire which consisting of sociodemographic variables, the Oslo Social Support Scale, and a Standardized Mini-mental State Examination (SMMSE) tool. Epi data version 3.0 was used to enter coded data and then exported into STATA 14 for analysis. Variables with a p-value < 0.25 in the bi-variable logistic regression were included in the multivariable regression. From multivariable logistic regression, variables having a p-value ≤ 0.05 were declared as statistically significant variables. In this study, a total of 403 study participants were involved, and 393 (97.5%) of them completed the survey. Among older participants screened for cognitive impairment, 43.8% was positive for cognitive impairment with a 95% CI (38.8-48.7%). The majority of the participants were (57.5%) male and (44.8%) aged over 60 years. After adjustment, the variables associated with cognitive impairment were age ≥ 75 years [odds ratio (OR) = 7.03, 95% CI 2.78-17.77] and between 61 and 74 years [OR = 3.18, 95% CI 1.81-5.59], and unable to read and write [OR = 5.05, 95% CI 2.04-12.50], low income level [OR = 2.60, 95% CI 1.26-5.20], being female [OR = 2.52, 95% CI 1.50-4.26], poor social support [OR = 2.50, 95% CI 1.30-4.81], and rural residence [OR = 2.39, 95% CI 1.26-4.51]. The prevalence of older participants who screened positively for cognitive impairment was high at Gondar town. The independent predictors of cognitive impairment among older individuals were older age, being unable to read and write, being female, low income, poor social support, and rural dwelling. Therefore, routine screening and social support, as well as free healthcare services for the mature and older community, are needed. Moreover, we strongly recommend the next researcher to use a diagnosis tool to estimate the actual prevalence of the problems among older people.

2. Customized protective visors enabled by closed loop controlled 4D printing.

Sci Rep

2022 May 9

Ji Q, Wang XV, Wang L

3. Factors affecting compliance with national accreditation essential safety standards in the Kingdom of Saudi Arabia.

Sci Rep

2022 May 9

Althumairi A, Alzahrani A, Alanzi T

Accreditation is a widespread culture internationally and nationally. The effectiveness of compliance with accreditation standards was positively correlated with health care settings' performance in multiple aspects: leadership, professional performance, patient safety and organizational culture. There is limited knowledge of the national compliance rate with accreditation standards. Therefore, it is important to assess the hospital compliance with accreditation rate in the Kingdom Saudi Arabia (KSA) and its related factors. This paper presents a quantitative cross-sectional study. Data were extracted from the annual Essential Safety Requirement (ESR) survey database from the Central Board for Accreditation of Health care Institutions (CBAHI) research center during the period 2016 to 2018. Hospitals that started their operation after the first ESR survey round in 2016 or shut down during the study period were excluded. The hospital scoring was on a scale of 0 to 100 and classified as follows: score 2 if the hospital satisfactory compliance (Fully Met) was ≥ 80% and score 1 if particular compliance (Partially Met) was ≥ 50% to < 80%. Then, a score of 0 indicated insufficient compliance (Not Met) when < 50% and a score of not applicable (NA) if the standard does not apply to the hospital. A total of 437 hospitals were surveyed in 20 regions in the KSA and had an overall compliance rate on average that was higher among private hospitals than among public hospitals (77% vs. 66%). Overall, private hospitals had a significantly better compliance rate than public hospitals (mean rate = 84% vs. 68%, respectively, P = 0.019). Large hospitals had more compliance with some standards than smaller hospitals. After adjusting for the year of the survey report, the private hospital type was more compliant than the public hospital. This study supports mandatory accreditation programs for both public and private health sectors, with increased monitoring by the concerned parties (i.e., CBAHI and the Ministry of Health). The authors encourage the application of accreditation for specialized and independent health services.

4. Chitinase-3-like protein-1 at hospital admission predicts COVID-19 outcome: a prospective cohort study.

Sci Rep

2022 May 9

De Lorenzo R(#), Sciorati C(#), Lorè NI

5. Army liposome formulation containing QS-21 render human monocyte-derived macrophages less permissive to HIV-1 infection by upregulating ABOBEC3A.

Sci Rep

2022 May 9

Jobe O, Kim J, Pinto DO

6. Exploring influencing factors of chronic obstructive pulmonary disease based on elastic net and Bayesian network.

Sci Rep

2022 May 9

Quan D(#), Ren J(#), Ren H(#)

7. Physics-informed attention-based neural network for hyperbolic partial differential equations: application to the Buckley-Leverett problem.

Sci Rep

2022 May 9

Rodriguez-Torrado R, Ruiz P, Cueto-Felgueroso L

8. Left atrium phasic impairments in paroxysmal atrial fibrillation patients assessed by cardiovascular magnetic resonance feature tracking.

Sci Rep

2022 May 9

Mojica-Pisciotti ML, Panovský R, Masárová L

9. A low-dimensional representation of arm movements and hand grip forces in post-stroke individuals.

Sci Rep

2022 May 9

Kanzler CM(#), Averta G(#), Schwarz A

10. Reaching alignment-profile-based accuracy in predicting protein secondary and tertiary structural properties without alignment.

Sci Rep

2022 May 9

Singh J, Paliwal K, Litfin T

11. The increased frequency of combined El Niño and positive IOD events since 1965s and its impacts on maritime continent hydroclimates.

Sci Rep

2022 May 9

Xiao HM, Lo MH, Yu JY.

12. Analyzing historical and future acute neurosurgical demand using an AI-enabled predictive dashboard.

Sci Rep

2022 May 9

Pandit AS, Jalal AHB, Toma AK

13. Experience sampling self-reports of social media use have comparable predictive validity to digital trace measures.

Sci Rep

2022 May 9

Verbeij T, Pouwels JL, Beyens I

14. Antimicrobial adhesive films by plasma-enabled polymerisation of m-cresol.

Sci Rep

2022 May 9

Hartl H, Li W, Michl TD

15. Height identification of water-permeable fractured zone based on synchronous movement in overlying strata.

Sci Rep

2022 May 9

Wang Z, Li J, Qin Z

16. Determination of a distinguished interferon gamma epitope recognized by monoclonal antibody relating to autoantibody associated immunodeficiency.

Sci Rep

2022 May 9

Yasamut U, Wisitponchai T, Lee VS

17. Optimising the photothrombotic model of stroke in the C57BI/6 and FVB/N strains of mouse.

Sci Rep

2022 May 9

Knezic A, Broughton BRS, Widdop RE

18. The value of Ki67 for the diagnosis of LSIL and the problems of p16 in the diagnosis of HSIL.

Sci Rep

2022 May 9

Liu J, Su S, Liu Y.

19. Estimating and explaining cross-country variation in the effectiveness of non-pharmaceutical interventions during COVID-19.

Sci Rep

2022 May 9

Banholzer N, Feuerriegel S, Vach W.

20. Gray wolf optimizer with bubble-net predation for modeling fluidized catalytic cracking unit main fractionator.

Sci Rep

2022 May 9

Wang X, Su C, Wang N

21. Springback effect and structural features during the drying of silica aerogels tracked by in-situ synchrotron X-ray scattering.

Sci Rep

2022 May 9

Zemke F, Scoppola E, Simon U

22. Darcy resistance flow of Sutterby nanofluid with microorganisms with applications of nano-biofuel cells.

Sci Rep

2022 May 7

Aldabesh A, Haredy A, Al-Khaled K

23. Proteins in human body fluids contain in vivo antigen analog of the melibiose-derived glycation product: MAGE.

Sci Rep

2022 May 7

Gostomska-Pampuch K, Gamian A, Rawicz-Pruszyński K

24. Bioinformatic analyses to uncover genes involved in trehalose metabolism in the polyploid sugarcane.

Sci Rep

2022 May 7

de Oliveira LP(#), Navarro BV(#), de Jesus Pereira JP

25. Arboreal camera trap reveals the frequent occurrence of a frugivore-carnivore in neotropical nutmeg trees.

Sci Rep

2022 May 7

Séguigne M, Coutant O, Bouton B

26. The numerical study of pressure and temperature effects on mechanical properties of baghdadite-based nanostructure: molecular dynamics simulation.

Sci Rep

2022 May 7

Liu Q, Bykanova O, Akhmadeev R

27. Latent class analysis of occupational accidents patterns among Iranian industry workers.

Sci Rep

2022 May 7

Saranjam B, Shirinzadeh I, Davoudi K

28. Research on permeable pores in collapse column fillings with different gradation structures.

Sci Rep

2022 May 7

Song S, Zhang T, Pan H

29. Single-shot femtosecond bulk micromachining of silicon with mid-IR tightly focused beams.

Sci Rep

2022 May 7

Mareev E, Pushkin A, Migal E

30. Actions of CSF2 and DKK1 on bovine embryo development and pregnancy outcomes are affected by composition of embryo culture medium.

Sci Rep

2022 May 7

Amaral TF, de Grazia JGV, Martinhao LAG

31. Multispectral pattern recognition measures change in drusen area in age-related macular degeneration with high congruency to expert graders.

Sci Rep

2022 May 6

Nam J, Ly A, Kalloniatis M

32. Within-person reproducibility of proteoforms related to inflammation and renal dysfunction.

Sci Rep

2022 May 6

Gao J, McCann A, Laupsa-Borge J

Protein biomarkers and microheterogeneity have attracted increasing attention in epidemiological and clinical research. Knowledge of within-person reproducibility over time is paramount to determine whether a single measurement accurately reflects an individual's long-term exposure. Yet, research investigating within-person reproducibility for proteoforms is limited. We investigated the reproducibility of the inflammatory markers C-reactive protein (CRP), serum amyloid A (SAA), and calprotectin (S100A8/9), and the renal function marker cystatin C (CnC) using a novel immuno-MALDI-TOF MS assay. Reproducibility, expressed as intraclass correlation coefficient (ICC), was calculated for 16 proteoforms using plasma samples of the Western Norway B Vitamin Intervention Trial (WENBIT) cohort collected 1-3 y apart from 295 stable angina pectoris (SAP) patients and 16 weeks apart from 38 subjects of the Intervention with Omega Fatty Acids in High-risk Patients with Hypertriglyceridemic Waist (OMEGA) trial with abdominal obesity but no other documented co-morbidities. ICCs for inflammatory markers were lower in WENBIT (CRP: 0.51, SAAt: 0.38, S100At: 0.31) compared to OMEGA subjects (CRP: 0.71, SAAt: 0.73, S100At: 0.48), while comparable for CnCt (WENBIT: 0.69, OMEGA: 0.67). Excluding SAP patients with elevated inflammation (CRP > 10 µg/ml) increased the ICC of SAAt to 0.55. Reduction of the time interval from 3 to 1 y in WENBIT group increased ICCs for all proteoforms. With a few exceptions ICCs did not differ between proteoforms of the same biomarker. ICCs were highest in OMEGA subjects with fair-to-good reproducibility for all markers. Reproducibility of SAA and S100A8/9 proteoforms in the WENBIT cohort was related to inflammation. This work will inform future clinical and epidemiological research which relies on single time point biomarker assessment to investigate inflammation and renal function.

33. Preliminary study for the application of Raman spectroscopy for the identification of Leishmania infected dogs.

Sci Rep

2022 May 6

Giuseppe A, Annastella F, Giannetto C

34. Cytochrome P450 2E1 predicts liver functional recovery from donation after circulatory death using air-ventilated normothermic machine perfusion.

Sci Rep

2022 May 6

Shi JH(#), Yang DJ(#), Jin Q(#)

35. Silica nanolayer coated capillary by hydrothermal sol-gel process for amines separation and detection of tyramine in food products.

Sci Rep

2022 May 6

Obma A, Hemwech P, Phoolpho S

36. Fertilizer type and humic acid improve the growth responses, nutrient uptake, and essential oil content on Coriandrum sativum L.

Sci Rep

2022 May 6

Rasouli F, Nasiri Y, Asadi M

37. Promoting a growth mindset decreases behavioral self-handicapping among students who are on the fixed side of the mindset continuum.

Sci Rep

2022 May 6

Török L, Szabó ZP, Orosz G.

38. A route towards the fabrication of large-scale and high-quality perovskite films for optoelectronic devices.

Sci Rep

2022 May 6

Rezaee E, Kutsarov D, Li B

39. Irisin protects cardiomyocytes against hypoxia/reoxygenation injury via attenuating AMPK mediated endoplasmic reticulum stress.

Sci Rep

2022 May 6

Yue R(#), Lv M(#), Lan M(#)

40. Shock wave formation from head-on collision of two subsonic vortex rings.

Sci Rep

2022 May 6

Bauer RL, Thomas CJ, Baker EVP

Vortex ring collisions have attracted intense interest in both water and air studies (Baird in Proc R Soc Lond Ser Math Phys Sci 409:59-65, 1987, Poudel et al. in Phys Fluids 33:096105, 2021, Lim and Nickels in Nature 357:225, 1992, New et al. in Exp Fluids 57:109, 2016, Suzuki et al. in Geophys Res Lett 34, 2007, Yan et al. in J Fluids Eng 140:054502, 2018, New et al. in J Fluid Mech 899, 2020, Cheng et al. in Phys Fluids 31:067107, 2019, Hernández and Reyes in 29:103604, 2017, Mishra et al. in Phys Rev Fluids, 2021, Zednikova et al. in Chem Eng Technol 42:843-850, 2019, Kwon et al. in Nature 600:64-69, 2021). These toroidal structures spin around a central axis and travel in the original direction of impulse while spinning around the core until inertial forces become predominant causing the vortex flow to spontaneously decay to turbulence (Vortex Rings, https://projects.iq.harvard.edu/smrlab/vortex-rings ). Previous studies have shown the collision of subsonic vortex rings resulting in reconnected vortex rings, but the production of a shock wave from the collision has not been demonstrated visibly (Lim and Nickels in Nature 357:225, 1992, Cheng et al. in Phys Fluids 31:067107, 2019). Here we present the formation of a shock wave due to the collision of explosively formed subsonic vortex rings. As the vortex rings travel at Mach 0.66 toward the collision point, they begin to trap high pressure air between them. Upon collision, high pressure air was imploded and released radially away from the axis of the collision, generating a visible shock wave traveling through and away from the colliding vortices at Mach 1.22. Our results demonstrate a pressure gradient with high pressure release creating a shock wave. We anticipate our study to be a starting point for more explosively formed vortex collisions. For example, explosives with different velocities of detonation could be tested to produce vortex rings of varying velocities.

41. Electron liquid state in the spin-[Formula: see text] anisotropic Kondo lattice.

Sci Rep

2022 May 6

Karnaukhov IN.

42. Eye movement analysis of children's attention for midline diastema.

Sci Rep

2022 May 6

Cho VY, Hsiao JH, Chan AB

43. The bifurcation angle is associated with the progression of saccular aneurysms.

Sci Rep

2022 May 6

Shimizu K, Kataoka H, Imai H

44. Unveiling the dynamics of ultra high velocity droplet impact on solid surfaces.

Sci Rep

2022 May 6

Tretola G, Vogiatzaki K.

The impact of a liquid droplet onto a solid surface is a phenomenon present in a wide range of natural processes and technological applications. In this study, we focus on impact conditions characterised by ultra high velocities (up to 500 m/s), to investigate-for the first time-how the impact dynamics change when the compressibility of the liquid in the droplet is no longer negligible. A water droplet impacting a dry substrate at four different velocities, from 50 to 500 m/s, is simulated. Such conditions are particularly relevant to aviation as well as industrial gas turbine engine risk management. Thus, numerical investigations as the one we present here provide a powerful tool to analyse the process. We find that increasing the impact velocity changes the flow field within and outside the droplet the moment that the compressibility can no longer be neglected, with the rise of pressure fronts in both regions. Increasing the impact velocity, the compressibility affects also the lamella formed and changes its ejection velocity observed over time (and thus the wetting behaviour) when the region shift from incompressible to compressible. Moreover, it is found that the maximum pressure observed at the wall during the impact is located at the corner of the impact, where the lamella is ejected, not in the centre, and it is influenced by the initial velocity. To predict the maximum pressure experienced by the surface during the high velocity impact, we propose a correlation based on the initial Weber and Reynolds number of the droplet. The complexity and the scales of the dynamics involved in the ultra-high velocity impact is limiting the experimental and analytical studies. To the best of our knowledge there are no experimental data currently available at such conditions. In this study, through numerical simulations, new insights about the impact dynamics at such conditions are provided.

45. Persistence versus dynamical seasonal forecasts of cereal crop yields.

Sci Rep

2022 May 6

Bento VA, Russo A, Dutra E

46. Quantitative and qualitative analysis of pulmonary arterial hypertension fibrosis using wide-field second harmonic generation microscopy.

Sci Rep

2022 May 5

Padrez Y, Golubewa L, Kulahava T

47. Longitudinal MRI-visible perivascular space (PVS) changes with long-duration spaceflight.

Sci Rep

2022 May 5

Hupfeld KE(#), Richmond SB(#), McGregor HR

Humans are exposed to extreme environmental stressors during spaceflight and return with alterations in brain structure and shifts in intracranial fluids. To date, no studies have evaluated the effects of spaceflight on perivascular spaces (PVSs) within the brain, which are believed to facilitate fluid drainage and brain homeostasis. Here, we examined how the number and morphology of magnetic resonance imaging (MRI)-visible PVSs are affected by spaceflight, including prior spaceflight experience. Fifteen astronauts underwent six T1-weighted 3 T MRI scans, twice prior to launch and four times following their return to Earth after ~ 6-month missions to the International Space Station. White matter MRI-visible PVS number and morphology were calculated using an established, automated segmentation algorithm. We validated our automated segmentation algorithm by comparing algorithm PVS counts with those identified by two trained raters in 50 randomly selected slices from this cohort; the automated algorithm performed similarly to visual ratings (r(48) = 0.77, p < 0.001). In addition, we found high reliability for four of five PVS metrics across the two pre-flight time points and across the four control time points (ICC(3,k) > 0.50). Among the astronaut cohort, we found that novice astronauts showed an increase in total PVS volume from pre- to post-flight, whereas experienced crewmembers did not (p = 0.020), suggesting that experienced astronauts may exhibit holdover effects from prior spaceflight(s). Greater pre-flight PVS load was associated with more prior flight experience (r = 0.60-0.71), though these relationships did not reach statistical significance (p > 0.05). Pre- to post-flight changes in ventricular volume were not significantly associated with changes in PVS characteristics, and the presence of spaceflight associated neuro-ocular syndrome (SANS) was not associated with PVS number or morphology. Together, these findings demonstrate that PVSs can be consistently identified on T1-weighted MRI scans, and that spaceflight is associated with PVS changes. Specifically, prior spaceflight experience may be an important factor in determining PVS characteristics.

48. Ambient mass spectrometry for rapid authentication of milk from Alpine or lowland forage.

Sci Rep

2022 May 5

Tata A, Massaro A, Riuzzi G

49. Biophysical studies of cancer cells' traverse-vessel behaviors under different pressures revealed cells' motion state transition.

Sci Rep

2022 May 5

Li X, Shi J, Gao Z

50. Traditional Chinese medicine extracts as novel corrosion inhibitors for AZ91 magnesium alloy in saline environment.

Sci Rep

2022 May 5

Li H, Fan M, Wang K

51. Assessing positive and negative valence systems to refine animal models of bipolar disorders: the example of GBR 12909-induced manic phenotype.

Sci Rep

2022 May 5

Bigot M, Vicq E, Lledo PM

52. Distribution of TAS2R38 bitter taste receptor phenotype and haplotypes among COVID-19 patients.

Sci Rep

2022 May 5

Risso D(#), Carmagnola D(#), Morini G(#)

53. Health burden in type 2 diabetes and prediabetes in The Maastricht Study.

Sci Rep

2022 May 5

Veugen MGJ, Onete VG, Henry RMA

Mortality in type 2 diabetes, is determined not only by classical complications, but also by comorbidities, and is linked to hyperglycaemia and apparent even in prediabetes. We aimed to comprehensively investigate, in a population-based cohort, health burden defined as the presence of comorbidities in addition to classical complications and cardiometabolic risk factors, in not only type 2 diabetes but also prediabetes. Such population-based study has not been performed previously. Extensive phenotyping was performed in 3,410 participants of the population-based Maastricht Study (15.0% prediabetes and 28.6% type 2 diabetes) to assess presence of 17 comorbidities, six classical complications, and ten cardiometabolic risk factors. These were added up into individual and combined sum scores and categorized. Group differences were studied with multinomial regression analyses adjusted for age and sex. Individuals with type 2 diabetes and prediabetes, as compared to normal glucose metabolism (NGM), had greater comorbidities, classical complications, cardiometabolic risk factors and combined sum scores (comorbidities sum score ≥ 3: frequencies (95% CI) 61.5% (57.6;65.4) and 41.2% (36.5;45.9) vs. 25.4% (23.5;27.4), p-trend < 0.001; classical complications ≥ 2 (26.6% (23.1;30.1; P < 0.001 vs. NGM) and 10.1% (7.8;12.7; P = 0.065 vs NGM) vs. 8.0% (6.9;9.3)); cardiometabolic risk factors ≥ 6 (39.7% (35.9;43.4) and 28.5% (24.5;32.6) vs. 14.0% (12.5;15.6); p-trend < 0.001); combined ≥ 8 (66.6% (62.7;70.5) and 48.4% (43.7;53.1) vs. 26.0%(24.1;28.0), p-trend < 0.001). Type 2 diabetes and prediabetes health burden was comparable to respectively 32 and 14 years of ageing. Our population-based study shows, independently of age and sex, a considerable health burden in both type 2 diabetes and prediabetes, which to a substantial extent can be attributed to comorbidities in addition to classical complications and cardiometabolic risk factors. Our findings emphasize the necessity of comorbidities' awareness in (pre)diabetes and for determining the exact role of hyperglycaemia in the occurrence of comorbidities.

54. Intraoperative aberrometry compared to preoperative Barrett True-K formula for intraocular lens power selection in eyes with prior refractive surgery.

Sci Rep

2022 May 5

Gasparian SA, Nassiri S, You H

55. Impact of environmental variables on yield related traits and bioactive compounds of the Persian fenugreek (Trigonella foenum-graecum L.) populations.

Sci Rep

2022 May 5

Rajabihashjin M, Zeinalabedini M, Asghari A

56. Accurate THz ellipsometry using calibration in time domain.

Sci Rep

2022 May 5

Mazaheri Z(#), Koral C(#), Andreone A.

57. Electron energization dynamics in interaction of self-generated magnetic vortices in upstream of collisionless electron/ion shocks.

Sci Rep

2022 May 5

Naseri N, Bochkarev SG, Bychenkov VY

58. Topography inversion in scanning tunneling microscopy of single-atom-thick materials from penetrating substrate states.

Sci Rep

2022 May 5

Park C, Yoon M.

59. A long-tailed marine reptile from China provides new insights into the Middle Triassic pachypleurosaur radiation.

Sci Rep

2022 May 5

Xu GH, Ren Y, Zhao LJ

60. Upper airway flow characteristics of childhood obstructive sleep apnea-hypopnea syndrome.

Sci Rep

2022 May 5

Cai H, Xu C, Xue H

61. Associations, overlaps and dissociations between apathy and fatigue.

Sci Rep

2022 May 5

Daumas L, Corbel C, Zory R

62. Rabies prevention practices and associated factors among household heads in Bure Zuria district, North West Ethiopia.

Sci Rep

2022 May 5

Wolelaw GA, Yalew WA, Azene AG

63. Non-circularly shaped conical diffraction.

Sci Rep

2022 May 5

Iqbal MW, Marsal N, Montemezzani G.

64. A database of calculated solution parameters for the AlphaFold predicted protein structures.

Sci Rep

2022 May 5

Brookes E, Rocco M.

65. Efficient processing of top-k frequent spatial keyword queries.

Sci Rep

2022 May 5

Xu T, Xu A, Mango J

66. Torsional vibration analysis of shaft with multi inertias.

Sci Rep

2022 May 5

Peng T, Yan Q.

67. Rational inference strategies and the genesis of polarization and extremism.

Sci Rep

2022 May 5

Kvam PD, Alaukik A, Mims CE

68. Groove rhythm stimulates prefrontal cortex function in groove enjoyers.

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2022 May 5

Fukuie T, Suwabe K, Kawase S

69. Evaluation of nutrient characteristics and bacterial community in agricultural soil groups for sustainable land management.

Sci Rep

2022 May 5

Wongkiew S, Chaikaew P, Takrattanasaran N

70. Perception thresholds and qualitative perceptions for electrocutaneous stimulation.

Sci Rep

2022 May 5

Dölker EM(#), Lau S(#), Bernhard MA

71. Climate change and modernization drive structural realignments in European grain production.

Sci Rep

2022 May 5

Pinke Z, Decsi B, Jámbor A

72. Longitudinal analysis of built environment and aerosol contamination associated with isolated COVID-19 positive individuals.

Sci Rep

2022 May 5

Horve PF, Dietz LG, Bowles G

73. Cost-effectiveness of managing HBV reactivation in patients with resolved HBV infection treated with anti-CD20 antibody for B-cell non-Hodgkin lymphoma.

Sci Rep

2022 May 5

Fujita M, Kusumoto S, Ishii I

74. Association of X-linked TLR-7 gene polymorphism with the risk of knee osteoarthritis: a case-control study.

Sci Rep

2022 May 4

Xi X, Mehmood A, Niu P

75. Multimorbidity is associated with the income, education, employment and health domains of area-level deprivation in adult residents in the UK.

Sci Rep

2022 May 4

Knies G, Kumari M.

76. Increased proinflammatory cytokines in tears correspond with conjunctival SARS-CoV-2 positivity in symptomatic COVID-19 patients.

Sci Rep

2022 May 4

Niedźwiedź A, Kawa M, Pius-Sadowska E

77. Effects of phosphorus-modified biochar as a soil amendment on the growth and quality of Pseudostellaria heterophylla.

Sci Rep

2022 May 4

Ng CWW, Wang YC, Ni JJ

78. Static and dynamic analyses of free-hinged-hinged-hinged-free beam in non-homogeneous gravitational field: application to gravity gradiometry.

Sci Rep

2022 May 4

Veryaskin AV, Meyer TJ.

79. Internal validation and comparison of predictive models to determine success rate of infertility treatments: a retrospective study of 2485 cycles.

Sci Rep

2022 May 4

Mehrjerd A, Rezaei H, Eslami S

80. Novel preparation of functional β-SiC fiber based In(2)O(3) nanocomposite and controlling of influence factors for the chemical gas sensing.

Sci Rep

2022 May 4

Otgonbayar Z, Jun Joo Y, Youn Cho K

The gas sensing ability of a pure β-SiC fiber is limited due to its low-sensitivity and selectivity with poor recovery time during a gas sensing test. The combination of functional β-SiC fibers with metal-oxide (MO) can lead to excellent electronic conductivity, boosted chemical activity, and high reaction activity with the target gas and β-SiC-In2O3 sensor material. Influence factors such as amounts of MO, current collectors, and gas species (CO2, O2 and without gas) for the gas sensing ability of β-SiC-In2O3 nanocomposite were determined at standard room temperature (25 °C) and high temperature (350 °C) conditions. The gas sensing ability of the functional β-SiC fiber was significantly enhanced by the loading of In2O3 metal-oxide. In addition, the MO junction on the β-SiC fiber was mainly subjected to the Si-C-O-In bond sensor layer with an effective electron-transfer ability. The gas sensing mechanism was based on the transfer of charges, in which the sensing material acted as an absorber or a donor of charges. The sensor material could use different current- collectors to support the electron transfer and gas sensing ability of the material. A 1:0.5M SiC-In2O3 coated Ni-foil current collector sensor showed better sensing ability for CO2 and O2 gases than other gas sensors at room temperature and high temperature conditions. The sensing result of the electrode was obtained with different current density values without or with gas purging conditions because CO2 and O2 gases had electron acceptor properties. During the gas sensing test, the sensor material donated electrons to target gases. The current value on the CV graph then significantly changed. Our obtained sample analysis data and the gas sensing test adequately demonstrated that MO junctions on functional β-SiC fibers could improve the sensitivity of a sensor material and particularly upgrade the sensor material for gas sensing.

81. Sparse representations of high dimensional neural data.

Sci Rep

2022 May 4

Mody SK, Rangarajan G.

82. Quaternary taphonomy: understanding the past through traces.

Sci Rep

2022 May 4

Blasco R.

83. Allergic rhinitis is associated with thromboembolic disease in pregnancy.

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2022 May 4

Wu CT, Tsao CH, Chen KT

84. Biliverdin regulates NR2E3 and zebrafish retinal photoreceptor development.

Sci Rep

2022 May 4

Connor B(#), Titialii-Torres K(#), Rockenhaus AE(#)

85. Brønsted acidity in zeolites measured by deprotonation energy.

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2022 May 4

Trachta M, Bulánek R, Bludský O

86. Sleep enhances reconsolidation-based strengthening of visuospatial memories.

Sci Rep

2022 May 4

Jones BJ, Chen ME, Simoncini L

87. Diagnostic performance of a 5-plex malaria immunoassay in regions co-endemic for Plasmodium falciparum, P. vivax, P. knowlesi, P. malariae and P. ovale.

Sci Rep

2022 May 4

Kho S, Anstey NM, Barber BE

88. Studying and mitigating the effects of data drifts on ML model performance at the example of chemical toxicity data.

Sci Rep

2022 May 4

Morger A(#), Garcia de Lomana M(#), Norinder U

Machine learning models are widely applied to predict molecular properties or the biological activity of small molecules on a specific protein. Models can be integrated in a conformal prediction (CP) framework which adds a calibration step to estimate the confidence of the predictions. CP models present the advantage of ensuring a predefined error rate under the assumption that test and calibration set are exchangeable. In cases where the test data have drifted away from the descriptor space of the training data, or where assay setups have changed, this assumption might not be fulfilled and the models are not guaranteed to be valid. In this study, the performance of internally valid CP models when applied to either newer time-split data or to external data was evaluated. In detail, temporal data drifts were analysed based on twelve datasets from the ChEMBL database. In addition, discrepancies between models trained on publicly-available data and applied to proprietary data for the liver toxicity and MNT in vivo endpoints were investigated. In most cases, a drastic decrease in the validity of the models was observed when applied to the time-split or external (holdout) test sets. To overcome the decrease in model validity, a strategy for updating the calibration set with data more similar to the holdout set was investigated. Updating the calibration set generally improved the validity, restoring it completely to its expected value in many cases. The restored validity is the first requisite for applying the CP models with confidence. However, the increased validity comes at the cost of a decrease in model efficiency, as more predictions are identified as inconclusive. This study presents a strategy to recalibrate CP models to mitigate the effects of data drifts. Updating the calibration sets without having to retrain the model has proven to be a useful approach to restore the validity of most models.

89. Clinical features of acute focal bacterial nephritis in adults.

Sci Rep

2022 May 4

Jiao S, Yan Z, Zhang C

90. Designing a new alginate-fibrinogen biomaterial composite hydrogel for wound healing.

Sci Rep

2022 May 4

Soleimanpour M(#), Mirhaji SS(#), Jafari S

Wound healing is a complex process and rapid healing necessitates a proper micro-environment. Therefore, design and fabrication of an efficacious wound dressing is an impressive innovation in the field of wound healing. The fabricated wound dressing in this scenario was designed using a combination of the appropriate coagulating and anti-bacterial materials like fibrinogen (as coagulating agent), nisin (as anti-bacterial agent), ethylenediaminetetraacetic acid (as anti-bacterial agent), and alginate (as wound healing agent). Biophysical characterization showed that the interaction of fibrinogen and alginate was associated with minor changes in the secondary structure of the protein. Conformational studies showed that the protein was structurally stable at 42 °C, is the maximum temperature of the infected wound. The properties of the hydrogel such as swelling, mechanical resistance, nisin release, antibacterial activity, cytotoxicity, gel porosity, and blood coagulation were assessed. The results showed a slow release for the nisin during 48 h. Antibacterial studies showed an inhibitory effect on the growth of Gram-negative and Gram-positive bacteria. The hydrogel was also capable to absorb a considerable amount of water and provide oxygenation as well as incorporation of the drug into its structure due to its sufficient porosity. Scanning electron microscopy showed pore sizes of about 14-198 µm in the hydrogel. Cell viability studies indicated high biocompatibility of the hydrogel. Blood coagulation test also confirmed the effectiveness of the synthesized hydrogel in accelerating the process of blood clot formation. In vivo studies showed higher rates of wound healing, re-epithelialization, and collagen deposition. According to the findings from in vitro as well as in vivo studies, the designed hydrogel can be considered as a novel attractive wound dressing after further prerequisite assessments.

91. Liver secretin receptor predicts portoenterostomy outcomes and liver injury in biliary atresia.

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2022 May 4

Godbole N, Nyholm I, Hukkinen M

92. Invasions of an obligate asexual daphnid species support the nearly neutral theory.

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2022 May 4

Ohtsuki H, Norimatsu H, Makino T

93. Progressive compressive sensing of large images with multiscale deep learning reconstruction.

Sci Rep

2022 May 4

Kravets V, Stern A.

94. Innovative diagnostic device for thickness measurement of conveyor belts in horizontal transport.

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2022 May 4

Kirjanów-Błażej A, Błażej R, Jurdziak L

95. Taxonomic and functional trait-based approaches suggest that aerobic and anaerobic soil microorganisms allow the natural attenuation of oil from natural seeps.

Sci Rep

2022 May 4

Cébron A, Borreca A, Beguiristain T

96. Experimental investigation of four-point bending of thin walled open section steel beam loaded and set in the shear center.

Sci Rep

2022 May 4

Obst M(#), Wasilewicz P(#), Adamiec J.

97. One-step nucleic acid amplification for intraoperative diagnosis of lymph node metastasis in lung cancer patients: a single-center prospective study.

Sci Rep

2022 May 4

Namba K, Suzawa K, Shien K

98. Role of the M point phonons for the dynamical stability of B2 compounds.

Sci Rep

2022 May 4

Ono S, Kobayashi D.

99. Giant nonlinear self-phase modulation of large-amplitude spin waves in microscopic YIG waveguides.

Sci Rep

2022 May 4

Merbouche H, Divinskiy B, Nikolaev KO

100. 3D Reconstruction of cellular images from microfabricated imagers using fully-adaptive deep neural networks.

Sci Rep

2022 May 4

Najafiaghdam H, Rabbani R, Gharia A

101. Higher dietary phytochemical index is associated with lower odds of knee osteoarthritis.

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2022 May 31

Amirkhizi F, Ghoreishy SM, Hamedi-Shahraki S

102. Highly sensitive and selective detection of dopamine with boron and sulfur co-doped graphene quantum dots.

Sci Rep

2022 May 31

Chatterjee M(#), Nath P(#), Kadian S

103. Bifunctional CePO(4)/CeO(2) nanocomposite as a promising heterogeneous catalyst for the enhancement of the ozonation recovery effect in the presence of chloride ions.

Sci Rep

2022 May 31

Fijołek L(#), Wolski L(#).

104. The effects of post-activation performance enhancement and different warm-up protocols on swim start performance.

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2022 May 31

Đurović M(#), Stojanović N(#), Stojiljković N(#)

105. Adipose and serum zinc alpha-2-glycoprotein (ZAG) expressions predict longitudinal change of adiposity, wasting and predict survival in dialysis patients.

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2022 May 31

Chan GC, Than WH, Kwan BC

106. Renal protection induced by physical exercise may be mediated by the irisin/AMPK axis in diabetic nephropathy.

Sci Rep

2022 May 31

Formigari GP, Dátilo MN, Vareda B

107. The new preparation method for paraffin-embedded samples applying scanning electron microscopy revealed characteristic features in asthma-induced mice.

Sci Rep

2022 May 31

Wakai K, Azuma K, Iwamura C

108. Scale, context, and heterogeneity: the complexity of the social space.

Sci Rep

2022 May 31

Balsa-Barreiro J, Menendez M, Morales AJ.

109. Online symptoms self-assessment during COVID-19 pandemic: an analysis of a COVID-19 portal responses from Canada.

Sci Rep

2022 May 31

Egbujie BA, Francisco K, Alarakhia M

COVID-19 case was first identified in Canada on January 25, 2020, on a Toronto resident who had travelled to Wuhan China, and not long after, the WHO declared the viral infection a pandemic. Ontario health West created an online self-assessment portal that allowed individuals in the health region and adjourning areas to report any COVID related symptoms. The purpose of this study was to evaluate the utility and usefulness of the Ontario Heath West online COVID-19 self-assessment portal. Record level data obtained from the Ontario Health West self-assessment portal was analyzed. Descriptive statistics using charts and graphs were used to characterize the distribution of responses to the portal. In-depth analysis using correlation, lead-lag analysis, and trend comparison with actual Government of Ontario COVID-19 cases for the region were also conducted. A total of 34,144 distinct responses were recorded on the portal between April 10 and July 29, 2020, with 1,250 (3.7%) responding positively to one of the emergency symptoms questions. Trend analysis showed a peak portal response in May 2020 with a smaller rise subsequently in July 2020, coinciding with the actual COVID-19 peak in the region. The five most reported symptoms on the portal were sore throat (17.2%), headache (12.9%), fatigue (12.3%), digestive problems (12.2%) and cough (9.1%). For four sub-regions, the trend of self-report on the portal positively lagged actual Public Health Ontario reported COVID-19 cases, while for one sub-region, the trend positively led the actual Public Health Ontario reported COVID-19 cases for the area. We found correlation between online COVID-19 self- assessment data and the confirmed COVID-19 cases in the Southwestern region of Ontario. Trends in the COVID-19 associated emergency symptoms reported on the portal also tracked confirmed COVID-19 cases in the community. Peak response to the portal coincided with the peak volume of confirmed cases in Ontario during the first wave of COVID-19 pandemic in Canada, suggesting some consistency between the experiences of portal users and patterns of COVID-19 illness in the community. The portal was a useful tool at the person-level because it provided guidance to individuals about how to access appropriate health services according to the symptoms that they reported and connected them with primary care, reducing unnecessary visit to health facilities for COVID-19 related care.

110. A benchmark study on economic impact of Neem Coated Urea on Indian agriculture.

Sci Rep

2022 May 31

Ramappa KB, Jadhav V, Manjunatha AV.

111. Photopic negative response recorded with RETeval system in eyes with optic nerve disorders.

Sci Rep

2022 May 31

Yamashita T, Kato K, Kondo M

112. Thinning increases forest resiliency during unprecedented drought.

Sci Rep

2022 May 31

Sankey T, Tatum J.

113. Pharmacologic modulation of 5-fluorouracil by folinic acid and pyridoxine for treatment of patients with advanced breast carcinoma.

Sci Rep

2022 May 31

Machover D, Goldschmidt E, Almohamad W

114. Chromatic discrimination measures in mature observers depend on the response window.

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2022 May 31

Fars J, Fernandes TP, Huchzermeyer C

115. Evidence for superior encoding of detailed visual memories in deaf signers.

Sci Rep

2022 May 31

Craig M, Dewar M, Turner G

116. Prevalence of left ventricular thrombus formation after mitral valve edge-to-edge repair.

Sci Rep

2022 May 31

Tichelbäcker T, Körber MI, Mauri V

117. Interactions between Caveolin-1 polymorphism and Plant-based dietary index on metabolic and inflammatory markers among women with obesity.

Sci Rep

2022 May 31

Abaj F, Mirzababaei A, Hosseininasab D

118. Facemask wearing does not impact neuro-electrical brain activity.

Sci Rep

2022 May 31

Tamimi A, Dahbour S, Al-Btush A

119. SARS-CoV-2 RNA in exhaled air of hospitalized COVID-19 patients.

Sci Rep

2022 May 30

Kurver L, van den Kieboom CH, Lanke K

120. Estimation of milk yield based on udder measures of Pelibuey sheep using artificial neural networks.

Sci Rep

2022 May 30

Angeles-Hernandez JC, Castro-Espinoza FA, Peláez-Acero A

121. Acidified drinking water attenuates motor deficits and brain pathology in a mouse model of a childhood neurodegenerative disorder.

Sci Rep

2022 May 30

Kovács AD, Langin LM, Hernandez JLG

122. A study of the oxidative processes in human plasma by time-resolved fluorescence spectroscopy.

Sci Rep

2022 May 30

Wybranowski T, Ziomkowska B, Cyrankiewicz M

123. Increasing salinity stress decreases the thermal tolerance of amphibian tadpoles in coastal areas of Taiwan.

Sci Rep

2022 May 30

Chuang MF(#), Cheng YJ(#), Andersen D

124. Competition between Pseudomonas aeruginosa and Staphylococcus aureus is dependent on intercellular signaling and regulated by the NtrBC two-component system.

Sci Rep

2022 May 30

Alford MA, Mann S, Akhoundsadegh N

125. Human magnetic sense is mediated by a light and magnetic field resonance-dependent mechanism.

Sci Rep

2022 May 30

Chae KS(#), Kim SC(#), Kwon HJ

126. Municipal biowaste treatment plants contribute to the contamination of the environment with residues of biodegradable plastics with putative higher persistence potential.

Sci Rep

2022 May 30

Steiner T(#), Zhang Y(#), Möller JN(#)

127. Optimization of physical quantities in the autoencoder latent space.

Sci Rep

2022 May 30

Park SM, Yoon HG, Lee DB

128. Behavioral and inflammatory sex differences revealed by celecoxib nanotherapeutic treatment of peripheral neuroinflammation.

Sci Rep

2022 May 30

Deal B, Reynolds LM, Patterson C

129. Group VR experiences can produce ego attenuation and connectedness comparable to psychedelics.

Sci Rep

2022 May 30

Glowacki DR, Williams RR, Wonnacott MD

130. Nutrient quality and maturity status of frass fertilizer from nine edible insects.

Sci Rep

2022 May 3

Beesigamukama D, Subramanian S, Tanga CM.

131. Between-hospital variations in 3-year survival among patients with newly diagnosed gastric, colorectal, and lung cancer.

Sci Rep

2022 May 3

Morishima T, Okawa S, Koyama S

132. Dielectric characterization and modelling of aqueous solutions involving sodium chloride and sucrose and application to the design of a bi-parameter RF-sensor.

Sci Rep

2022 May 3

Bakam Nguenouho OS, Chevalier A, Potelon B

133. Trends of influenza vaccination coverage in pregnant women: a ten-year analysis from a French healthcare database.

Sci Rep

2022 May 3

Corbeau M, Mulliez A, Chenaf C

Pregnant women have a high risk of severe influenza, associated with obstetrical complications. The World Health Organization (WHO) has recommended influenza vaccination for all pregnant women since 2012. The vaccination coverage remains low worldwide, and in Europe, due to a lack of proposition from the health care providers, and a high refusal rate from the women. The primary aim of this study was to estimate the influenza vaccination coverage (IVC) in a population of pregnant women in France, and to analyse its evolution from 2009 to 2018. The secondary objective was to describe the vaccinated population and to find determinants associated with the vaccination. This retrospective cohort study is based on the EGB French health care database, a representative sample of the French population containing data from the health insurance system. All pregnant women who delivered medically or spontaneously over the 2009-2018 period were included. In the 2009-2018 period, only 1.2% pregnant women were vaccinated against influenza (n = 875/72,207; 95% CI 1.14-1.30). The IVC slightly increased after the 2012 WHO recommendation, from 0.33 to 1.79% (p < 0.001) but remained extremely low (4.1% in 2018). Women younger than 25 years old had a low coverage (0.6%) whereas women over 35 years old were more likely to get the influenza vaccine (1.7%; OR: 2.82, 95% CI 2.14-3.71). The vaccination behavior was not influenced by multifetal pregnancy or parity, but socio-economically deprived women were less likely to be vaccinated (OR: 0.81, 95% CI: 0.67-0.98). Women with pre-existing medical conditions had an overall higher vaccination rate (2.5%; OR: 2.32, 95% CI: 1.94-2.77). The vaccine was mainly prescribed by family physicians (58%). Influenza vaccination in pregnant women in France remains very low, particularly in younger, healthy women, and measures such as information campaigns towards pregnant women and studies of the knowledge, attitudes, and practices of the health care professionals need to be undertaken to improve the coverage.

134. COVID-19 patient serum less potently inhibits ACE2-RBD binding for various SARS-CoV-2 RBD mutants.

Sci Rep

2022 May 3

Junker D, Dulovic A, Becker M

135. Open label safety and efficacy pilot to study mitigation of equine recurrent uveitis through topical suppressor of cytokine signaling-1 mimetic peptide.

Sci Rep

2022 May 3

Plummer CE(#), Polk T(#), Sharma J

136. Quality of life and patient satisfaction with raloxifene/cholecalciferol combination therapy in postmenopausal women.

Sci Rep

2022 May 3

Lee DY, Chung YS.

137. Reliability, usability and identified need for home-based cardiometabolic health self-assessment during the COVID-19 pandemic in Soweto, South Africa.

Sci Rep

2022 May 3

Calvert C, Kolkenbeck-Ruh A, Crouch SH

138. Timescale of a magmatic-hydrothermal system revealed by (40)Ar-(39)Ar geochronology: the Mio-Pliocene Campiglia Marittima system (Tuscany, Italy).

Sci Rep

2022 May 3

Di Vincenzo G, Vezzoni S, Dini A

139. PCA-based sub-surface structure and defect analysis for germanium-on-nothing using nanoscale surface topography.

Sci Rep

2022 May 3

Jeong J, Kim T, Lee BJ

Empty space in germanium (ESG) or germanium-on-nothing (GON) are unique self-assembled germanium structures with multiscale cavities of various morphologies. Due to their simple fabrication process and high-quality crystallinity after self-assembly, they can be applied in various fields including micro-/nanoelectronics, optoelectronics, and precision sensors, to name a few. In contrast to their simple fabrication, inspection is intrinsically difficult due to buried structures. Today, ultrasonic atomic force microscopy and interferometry are some prevalent non-destructive 3-D imaging methods that are used to inspect the underlying ESG structures. However, these non-destructive characterization methods suffer from low throughput due to slow measurement speed and limited measurable thickness. To overcome these limitations, this work proposes a new methodology to construct a principal-component-analysis based database that correlates surface images with empirically determined sub-surface structures. Then, from this database, the morphology of buried sub-surface structure is determined only using surface topography. Since the acquisition rate of a single nanoscale surface micrograph is up to a few orders faster than a thorough 3-D sub-surface analysis, the proposed methodology benefits from improved throughput compared to current inspection methods. Also, an empirical destructive test essentially resolves the measurable thickness limitation. We also demonstrate the practicality of the proposed methodology by applying it to GON devices to selectively detect and quantitatively analyze surface defects. Compared to state-of-the-art deep learning-based defect detection schemes, our method is much effortlessly finetunable for specific applications. In terms of sub-surface analysis, this work proposes a fast, robust, and high-resolution methodology which could potentially replace the conventional exhaustive sub-surface inspection schemes.

140. Improved methods for the detection and quantification of SARS-CoV-2 RNA in wastewater.

Sci Rep

2022 May 3

Peinado B, Martínez-García L, Martínez F

141. Remofuscin induces xenobiotic detoxification via a lysosome-to-nucleus signaling pathway to extend the Caenorhabditis elegans lifespan.

Sci Rep

2022 May 3

Oh M, Yeom J, Schraermeyer U

142. Generalizing predictions to unseen sequencing profiles via deep generative models.

Sci Rep

2022 May 3

Oh M, Zhang L.

143. Predictive value of clinical and (18)F-FDG-PET/CT derived imaging parameters in patients undergoing neoadjuvant chemoradiation for esophageal squamous cell carcinoma.

Sci Rep

2022 May 3

Marr L, Haller B, Pyka T

Aim of this study was to validate the prognostic impact of clinical parameters and baseline 18F-FDG-PET/CT derived textural features to predict histopathologic response and survival in patients with esophageal squamous cell carcinoma undergoing neoadjuvant chemoradiation (nCRT) and surgery. Between 2005 and 2014, 38 ESCC were treated with nCRT and surgery. For all patients, the 18F-FDG-PET-derived parameters metabolic tumor volume (MTV), SUVmax, contrast and busyness were calculated for the primary tumor using a SUV-threshold of 3. The parameter uniformity was calculated using contrast-enhanced computed tomography. Based on histopathological response to nCRT, patients were classified as good responders (< 10% residual tumor) (R) or non-responders (≥ 10% residual tumor) (NR). Regression analyses were used to analyse the association of clinical parameters and imaging parameters with treatment response and overall survival (OS). Good response to nCRT was seen in 27 patients (71.1%) and non-response was seen in 11 patients (28.9%). Grading was the only parameter predicting response to nCRT (Odds Ratio (OR) = 0.188, 95% CI: 0.040-0.883; p = 0.034). No association with histopathologic treatment response was seen for any of the evaluated imaging parameters including SUVmax, MTV, busyness, contrast and uniformity. Using multivariate Cox-regression analysis, the heterogeneity parameters busyness (Hazard Ratio (HR) = 1.424, 95% CI: 1.044-1.943; p = 0.026) and contrast (HR = 6.678, 95% CI: 1.969-22.643; p = 0.002) were independently associated with OS, while no independent association with OS was seen for SUVmax and MTV. In patients with ESCC undergoing nCRT and surgery, baseline 18F-FDG-PET/CT derived parameters could not predict histopathologic response to nCRT. However, the PET/CT derived features busyness and contrast were independently associated with OS and should be further investigated.

144. Real-time realizable mobile imaging photoplethysmography.

Sci Rep

2022 May 3

Lee H(#), Ko H(#), Chung H(#)

145. High-sensitivity C-reactive protein could be a potential indicator of bone mineral density in adolescents aged 10-20 years.

Sci Rep

2022 May 3

Ye W(#), Cheng S(#), Xiao J

146. Association between circulating CD34-positive cell count and height loss among older men.

Sci Rep

2022 May 3

Shimizu Y, Kawashiri SY, Nobusue K

147. Pesticide risk to managed bees during blueberry pollination is primarily driven by off-farm exposures.

Sci Rep

2022 May 3

Graham KK, Milbrath MO, Zhang Y

When managed bee colonies are brought to farms for crop pollination, they can be exposed to pesticide residues. Quantifying the risk posed by these exposures can indicate which pesticides are of the greatest concern and helps focus efforts to reduce the most harmful exposures. To estimate the risk from pesticides to bees while they are pollinating blueberry fields, we sampled blueberry flowers, foraging bees, pollen collected by returning honey bee and bumble bee foragers at colonies, and wax from honey bee hives in blooming blueberry farms in southwest Michigan. We screened the samples for 261 active ingredients using a modified QuEChERS method. The most abundant pesticides were those applied by blueberry growers during blueberry bloom (e.g., fenbuconazole and methoxyfenozide). However, we also detected highly toxic pesticides not used in this crop during bloom (or other times of the season) including the insecticides chlorpyrifos, clothianidin, avermectin, thiamethoxam, and imidacloprid. Using LD50 values for contact and oral exposure to honey bees and bumble bees, we calculated the Risk Quotient (RQ) for each individual pesticide and the average sample RQ for each farm. RQ values were considered in relation to the U.S. Environmental Protection Agency acute contact level of concern (LOC, 0.4), the European Food Safety Authority (EFSA) acute contact LOC (0.2) and the EFSA chronic oral LOC (0.03). Pollen samples were most likely to exceed LOC values, with the percent of samples above EFSA's chronic oral LOC being 0% for flowers, 3.4% for whole honey bees, 0% for whole bumble bees, 72.4% for honey bee pollen in 2018, 45.4% of honey bee pollen in 2019, 46.7% of bumble bee pollen in 2019, and 3.5% of honey bee wax samples. Average pollen sample RQ values were above the EFSA chronic LOC in 92.9% of farms in 2018 and 42.9% of farms in 2019 for honey bee collected pollen, and 46.7% of farms for bumble bee collected pollen in 2019. Landscape analyses indicated that sample RQ was positively correlated with the abundance of apple and cherry orchards located within the flight range of the bees, though this varied between bee species and landscape scale. There was no correlation with abundance of blueberry production. Our results highlight the need to mitigate pesticide risk to bees across agricultural landscapes, in addition to focusing on the impact of applications on the farms where they are applied.

148. Optimization study of plasmonic cell fusion.

Sci Rep

2022 May 3

Belansky J, Yelin D.

149. High throughput screen for the improvement of inducible promoters for tumor microenvironment cues.

Sci Rep

2022 May 3

Sharabi O(#), Greenshpan Y(#), Ofir N

150. Statistical optimization for simultaneous removal of methyl red and production of fatty acid methyl esters using fresh alga Scenedesmus obliquus.

Sci Rep

2022 May 3

El-Naggar NE, Hamouda RA, Abou-El-Souod GW.

Microalgae are a diverse group of microorganisms, the majority of which are photosynthetic in nature. Microalgae have different applications, the most important of which is the biological treatment of wastewater. Microalgae grow in various types of wastewater, such as wastewater polluted by Azo dyes, due to microalgae using wastewater as a culture medium, which contains many nutrients like nitrogen, phosphate, and carbon sources. Microalgae grow in various types of wastewater, such as wastewater polluted by Azo dyes, due to microalgae using wastewater as a culture medium, which contains many nutrients like nitrogen, phosphate, and carbon sources. So, microalgae are used for bioremediation of wastewater due to the efficiency of growing in wastewater and for the high production of lipids followed by trans-esterification to biodiesel. Face-centered central composite design (FCCCD) was used to determine the factors that have the most significant impact on the simultaneous decolorization of methyl red and lipid production by the fresh green alga Scenedesmus obliquus. The predicted results indicated that the alga decolorized 70.15% methyl red and produced 20.91% lipids by using 1 g/L nitrogen, an incubation time of 10 days, a pH of 8, and the concentration of methyl red is 17.65 mg/L. The dry biomasses of S. obliquus were also examined by SEM and FTIR before and after treatment with methyl red. SEM and FTIR showed that the properties of dry S. obliquus were altered after the biosorption of methyl red. According to GC-MS analysis of hexane extracts of S. obliquus, the lipid profile differed before and after methyl red decolorization. The results proved that it is possible to use S. obliquus to remove dyes and produce renewable fuels such as biodiesel. The novelty of this study is that this is the first time in which the effect of nitrogen concentrations in the medium used for algal growth on the removal of dye has been studied.

151. Adverse events associated with JAK inhibitors in 126,815 reports from the WHO pharmacovigilance database.

Sci Rep

2022 May 3

Hoisnard L, Lebrun-Vignes B, Maury S

152. Clinical prediction model of pathological response following neoadjuvant chemoradiotherapy for rectal cancer.

Sci Rep

2022 May 3

Shin JK, Huh JW, Lee WY

153. High sensitivity refractive index sensing using zone plate metasurfaces with a conical phase profile.

Sci Rep

2022 May 28

Abdel-Galil M, Swillam M, Ismail Y

154. Quantitative study for control of air-liquid segmented flow in a 3D-printed chip using a vacuum-driven system.

Sci Rep

2022 May 28

Hong H, Song JM, Yeom E.

The formation of droplets or bubbles in a microfluidic system is a significant topic requiring device miniaturization and a small volume of samples. Especially, a two-phase segmented flow can be applied to micro-mixing for chemical reactions and the treatment of heat and mass transfer. In this study, a flow of liquid slugs and bubbles was generated in a 3D-printed chip and controlled by a single pump creating a vacuum at the outlet. The pump and chip device were integrated to form a simple and portable system. The size and flow rate of liquid slugs, obtained through image processing techniques, were analyzed considering several parameters related to hydraulic resistance and pressure drop. In addition, the effect of segmentation on mixing was observed by measuring the intensity change using two different colored inks. The hydraulic resistance of air and liquid flows can be controlled by changing the tube length of air flow and the viscosity of liquid flow. Because the total pressure drop along the channel was produced using a single pump at the outlet of the channel, the size and flow rate of the liquid slugs showed a near linear relation depending on the hydraulic resistances. In contrast, as the total pressure varied with the flow rate of the pump, the size of the liquid slugs showed a nonlinear trend. This indicates that the frequency of the liquid slug formation induced by the squeezed bubble may be affected by several forces during the development of the liquid slugs and bubbles. In addition, each volume of liquid slug segmented by the air is within the range of 10-1 to 2 µL for this microfluidic system. The segmentation contributes to mixing efficiency based on the increased homogeneity factor of liquid. This study provides a new insight to better understand the liquid slug or droplet formation and predict the segmented flow based on the relationship between the resistance, flow rate, and pressure drop.

155. Flexible adjustment of anticipations in human outcome processing.

Sci Rep

2022 May 27

Habiby Alaoui S, Adam-Darqué A, Schnider A.

156. Ocean temperatures through the Phanerozoic reassessed.

Sci Rep

2022 May 27

Grossman EL, Joachimski MM.

157. Lasiodiplodia theobromae as a causal pathogen of leaf blight, stem canker, and pod rot of Theobroma cacao in Malaysia.

Sci Rep

2022 May 27

Huda-Shakirah AR, Mohamed Nor NMI, Zakaria L

158. Evaluation of color changes during stability studies using spectrophotometric chromaticity measurements versus visual examination.

Sci Rep

2022 May 27

Sakiroff LM, Chennell P, Yessaad M

159. Integration of thermal imaging and neural networks for mechanical strength analysis and fracture prediction in 3D-printed plastic parts.

Sci Rep

2022 May 27

Boiko DA(#), Korabelnikova VA(#), Gordeev EG

160. Polyploid giant cancer cells are dependent on cholesterol for progeny formation through amitotic division.

Sci Rep

2022 May 27

White-Gilbertson S, Lu P, Esobi I

161. Prenatal exposure to phthalate and decreased body mass index of children: a systematic review and meta-analysis.

Sci Rep

2022 May 27

Lee DW, Lim HM, Lee JY

162. Identification of metabolite extraction method for targeted exploration of antimicrobial resistance associated metabolites of Klebsiella pneumoniae.

Sci Rep

2022 May 27

Kumar A, Singh S, Gupta SK

Antimicrobial resistant Klebsiella pneumoniae (K. pneumoniae), as being a pathogen of critical clinical concern, urgently demands effective therapeutic options. However, the discovery of novel antibiotics over the last three decades has declined drastically and necessitates exploring novel strategies. Metabolomic modulation has been the promising approach for the development of effective therapeutics to deal with AMR; however, only limited efforts have been made to-date, possibly due to the unavailability of suitable metabolites extraction protocols. Therefore, in order to establish a detailed metabolome of K. pneumoniae and identify a method for targeted exploration of metabolites that are involved in the regulation of AMR associated processes, metabolites were extracted using multiple methods of metabolites extraction (freeze-thaw cycle (FTC) and sonication cycle (SC) method alone or in combination (FTC followed by SC; FTC + SC)) from K. pneumoniae cells and then identified using an orbitrap mass analyzer (ESI-LC-MS/MS). A total of 151 metabolites were identified by using FTC, 132 metabolites by using FTC+SC, 103 metabolites by using SC and 69 metabolites common among all the methods used which altogether enabled the identification of 199 unique metabolites. Of these 199, 70 metabolites were known to have an association with AMR phenotype and among these, the FTC + SC method yielded better (identified 55 metabolites), quantitatively and qualitatively compared to FTC and SC alone (identified 51 and 41 metabolites respectively). Each method of metabolite extraction showed a definite degree of biasness and specificity towards chemical classes of metabolites and jointly contributed to the development of a detailed metabolome of the pathogen. FTC method was observed to give higher metabolomic coverage as compared to SC alone and FTC + SC. However, FTC + SC resulted in the identification of a higher number of AMR associated metabolites of K. pneumoniae compared to FTC and SC alone.

163. Electroantennogram and machine learning reveal a volatile blend mediating avoidance behavior by Tuta absoluta females to a wild tomato plant.

Sci Rep

2022 May 27

Miano RN, Ayelo PM, Musau R

Tomato cultivation is threatened by the infestation of the nocturnal invasive tomato pinworm, Tuta absoluta. This study was based on field observations that a wild tomato plant, Solanum lycopersicum var. cerasiforme, grown in the Mount Kenya region, Kenya, is less attacked by T. absoluta, unlike the cultivated tomato plants like S. lycopersicum (var. Rambo F1). We hypothesized that the wild tomato plant may be actively avoided by gravid T. absoluta females because of the emission of repellent allelochemical constituents. Therefore, we compared infestation levels by the pest in field monocrops and intercrops of the two tomato genotypes, characterized the headspace volatiles, then determined the compounds detectable by the insect through gas chromatography-linked electroantennography (GC-EAG), and finally performed bioassays using a blend of four EAG-active compounds unique to the wild tomato. We found significant reductions in infestation levels in the monocrop of the wild tomato, and intercrops of wild and cultivated tomato plants compared to the monocrop of the cultivated tomato plant. Quantitative and qualitative differences were noted between volatiles of the wild and cultivated tomato plants, and between day and night volatile collections. The most discriminating compounds between the volatile treatments varied with the variable selection or machine learning methods used. In GC-EAG recordings, 16 compounds including hexanal, (Z)-3-hexenol, α-pinene, β-myrcene, α-phellandrene, β-phellandrene, (E)-β-ocimene, terpinolene, limonene oxide, camphor, citronellal, methyl salicylate, (E)-β-caryophyllene, and others tentatively identified as 3,7,7-Trimethyl-1,3,5-cycloheptatriene, germacrene D and cis-carvenone oxide were detected by antennae of T. absoluta females. Among these EAG-active compounds, (Z)-3-hexenol, α-pinene, α-phellandrene, limonene oxide, camphor, citronellal, (E)-β-caryophyllene and β-phellandrene are in the top 5 discriminating compounds highlighted by the machine learning methods. A blend of (Z)-3-hexenol, camphor, citronellal and limonene oxide detected only in the wild tomato showed dose-dependent repellence to T. absoluta females in wind tunnel. This study provides some groundwork for exploiting the allelochemicals of the wild tomato in the development of novel integrated pest management approaches against T. absoluta.

164. Differences in composition of interdigital skin microbiota predict sheep and feet that develop footrot.

Sci Rep

2022 May 27

Clifton R, Monaghan EM, Green MJ

165. Underwater image restoration with Haar wavelet transform and ensemble of triple correction algorithms using Bootstrap aggregation and random forests.

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2022 May 27

Rowghanian V.

166. Adipokine human Resistin promotes obesity-associated inflammatory intervertebral disc degeneration via pro-inflammatory cytokine cascade activation.

Sci Rep

2022 May 27

Shin JH, Park S, Cho H

167. Multi-cultural cities reduce disadvantages in recognizing naturalistic images of other-race faces: evidence from a novel face learning task.

Sci Rep

2022 May 27

Zhou X, Mondloch CJ, Chien SH

168. Superabsorbent cellulose-based hydrogels cross-liked with borax.

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2022 May 26

Tanpichai S, Phoothong F, Boonmahitthisud A.

169. Determinants of variability in signature whistles of the Mediterranean common bottlenose dolphin.

Sci Rep

2022 May 26

La Manna G, Rako-Gospić N, Pace DS

170. Dynamics of radiative Williamson hybrid nanofluid with entropy generation: significance in solar aircraft.

Sci Rep

2022 May 26

Hussain SM.

171. The role of surface chemistry on CO(2) adsorption in biomass-derived porous carbons by experimental results and molecular dynamics simulations.

Sci Rep

2022 May 26

Khosrowshahi MS, Abdol MA, Mashhadimoslem H

172. The effects of contracting Covid-19 on cognitive failures at work: implications for task performance and turnover intentions.

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2022 May 25

Beck JW, Flow A.

173. Personality mediates the association between juvenile conduct problems and adulthood mood disorders.

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2022 May 25

Chan JH, Chen HC, Chen IM

174. Fabrication of benzoyl chloride treated tiger-nut fiber reinforced insect repellent hybrid composite.

Sci Rep

2022 May 25

Babayo H, Musa H, Garba MD.

175. Effect of heat exposure on the growth and developmental competence of bovine oocytes derived from early antral follicles.

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2022 May 25

Kawano K, Sakaguchi K, Madalitso C

176. Relativistic motions of spin-zero quantum oscillator field in a global monopole space-time with external potential and AB-effect.

Sci Rep

2022 May 25

Ahmed F.

177. Optimized removal of hexavalent chromium from water using spent tea leaves treated with ascorbic acid.

Sci Rep

2022 May 25

Zaib Q, Kyung D.

178. A portable non-invasive microwave based head imaging system using compact metamaterial loaded 3D unidirectional antenna for stroke detection.

Sci Rep

2022 May 25

Islam MS, Islam MT, Almutairi AF.

179. Ionic liquid-assisted synthesis of chitin-ethylene glycol hydrogels as electrolyte membranes for sustainable electrochemical capacitors.

Sci Rep

2022 May 25

Wysokowski M, Nowacki K, Jaworski F

180. The effects of CuO/CeO(2) mixture nanoparticles on the performance of a vapor compression refrigeration system.

Sci Rep

2022 May 25

Mohamed HA, Camdali U, Biyikoglu A

181. The importance of extrinsic and intrinsic compensatory mechanisms to body posture of competitive athletes a systematic review and meta-analysis.

Sci Rep

2022 May 25

Zwierzchowska A, Gaweł E, Maszczyk A

182. Comparative transcriptome profiles of human dental pulp stem cells from maxillary and mandibular teeth.

Sci Rep

2022 May 25

Faruangsaeng T, Thaweesapphitak S, Khamwachirapitak C

The molecular control of tooth development is different between the maxilla and mandible, contributing to different tooth shapes and locations; however, whether this difference occurs in human permanent teeth is unknown. The aim of this study was to investigate and compare the transcriptome profiles of permanent maxillary and mandibular posterior teeth. Ten participants who had a pair of opposing premolars or molars extracted were recruited. The RNA obtained from cultured dental pulp stem cells underwent RNA-sequencing and qRT-PCR. The transcriptome profiles of two opposing premolar pairs and two molar pairs demonstrated that the upper premolars, lower premolars, upper molars, and lower molars expressed the same top-ranked genes, comprising FN1, COL1A1, COL1A2, ACTB, and EEFIA1, which are involved in extracellular matrix organization, immune system, signal transduction, hemostasis, and vesicle-mediated transport. Comparative transcriptome analyses of each/combined tooth pairs demonstrated that PITX1 was the only gene with different expression levels between upper and lower posterior teeth. PITX1 exhibited a 64-fold and 116-fold higher expression level in lower teeth compared with their upper premolars and molars, respectively. These differences were confirmed by qRT-PCR. Taken together, this study, for the first time, reveals that PITX1 is expressed significantly higher in mandibular posterior teeth compared with maxillary posterior teeth. The difference is more evident in the molars compared with premolars and consistent with its expression pattern in mouse developing teeth. We demonstrate that differences in lower versus upper teeth gene expression during odontogenesis occur in permanent teeth and suggest that these differences should be considered in molecular studies of dental pulp stem cells. Our findings pave the way to develop a more precise treatment in regenerative dentistry such as gene-based therapies for dentin/pulp regeneration and regeneration of different tooth types.

183. Therapeutic potential of biogenic and optimized silver nanoparticles using Rubia cordifolia L. leaf extract.

Sci Rep

2022 May 25

Chandraker SK, Lal M, Khanam F

184. Longer amplicons provide better sensitivity for electrochemical sensing of viral nucleic acid in water samples using PCB electrodes.

Sci Rep

2022 May 25

Ahuja S(#), Kumar MS(#), Nandeshwar R

185. Chronic treatment with serelaxin mitigates adverse remodeling in a murine model of ischemic heart failure and modulates bioactive sphingolipid signaling.

Sci Rep

2022 May 25

Devarakonda T, Valle Raleigh J, Mauro AG

186. High CRP-albumin ratio predicts poor prognosis in transplant ineligible elderly patients with newly diagnosed acute myeloid leukemia.

Sci Rep

2022 May 25

Senjo H, Onozawa M, Hidaka D

187. Exploration for adequate non-diffractive beam generation in dense scattering media.

Sci Rep

2022 May 25

Xiafukaiti A, Lagrosas N, Shiina T.

188. Polymer-assisted enzyme induced carbonate precipitation for non-ammonia emission soil stabilization.

Sci Rep

2022 May 25

Yan Z, Gowthaman S, Nakashima K

189. Tai Chi versus conventional exercise for improving cognitive function in older adults: a pilot randomized controlled trial.

Sci Rep

2022 May 25

Yu AP, Chin EC, Yu DJ

Studies have shown that Tai Chi and conventional exercise can modify the brain through distinct mechanisms, resulting in different brain adaptations. Therefore, it is conceivable to speculate that these two exercise modalities may have different effects on improving cognitive function. This study was a parallel group, assessor-blinded, pilot randomized controlled trial comparing the effects of Tai Chi and conventional exercise on improving cognitive function in older persons with mild cognitive impairment (MCI). A total of 34 adults aged ≥ 50 years with MCI were randomized (1:1:1) to the Tai Chi group (TC, n = 10, 3 sessions of 60-min Yang-style Tai Chi training per week for 24 weeks), conventional exercise group (EX: n = 12, 3 sessions of 60-min fitness training per week for 24 weeks), or control group (CON: n = 12, no intervention). Global cognitive function assessed by the Hong Kong version of the Montreal Cognitive Assessment (MoCA-HK) and performance in various cognitive domains were examined at baseline, and 12 and 24 weeks of the intervention. Both exercise groups showed improved global cognitive function as measured by MoCA-HK compared with the control group after 12 and 24 weeks of the intervention, (all P < 0.001). Only TC achieved clinically relevant improvement on global cognitive function at week 12. Both exercise groups achieved clinically relevant improvements at the end of the interventions at week 24. Compared with EX, TC exhibited greater improvements on global cognitive function indicated by MoCA-HK after 12 weeks of the intervention (P < 0.001) and cognitive flexibility indicated by part B/A ratio score of the Trail Making Test throughout the study (all P < 0.05). Both interventions were equally effective in improving the other examined cognitive domains. Further studies are needed to substantiate the superior long-term benefits of Tai Chi on global cognitive function compared with conventional exercise, and dissect the underlying mechanisms of the two exercises on improving cognitive domains and the corresponding brain adaptations. Trial registration: This study was registered at clinicaltrials.gov (Trial registration number: NCT04248400; first registration date: 30/01/2020).

190. Signaling events evoked by domain III of envelop glycoprotein of tick-borne encephalitis virus and West Nile virus in human brain microvascular endothelial cells.

Sci Rep

2022 May 25

Bhide K, Mochnáčová E, Tkáčová Z

191. Impact of the revised definition on incidence and outcomes of acute exacerbation of idiopathic pulmonary fibrosis.

Sci Rep

2022 May 25

Yoo JW(#), Kim J(#), Song JW.

192. Symptom burden correlates to impairment of diffusion capacity and exercise intolerance in long COVID patients.

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2022 May 25

Kersten J, Wolf A, Hoyo L

193. A novel decentralized federated learning approach to train on globally distributed, poor quality, and protected private medical data.

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2022 May 25

Nguyen TV, Dakka MA, Diakiw SM

194. Proteomic profiling of concurrently isolated primary microvascular endothelial cells, pericytes, and vascular smooth muscle cells from adult mouse heart.

Sci Rep

2022 May 25

Cao Z, Minnier J, Liu L

195. Exploring 3D elastic-wave scattering at interfaces using high-resolution phased-array system.

Sci Rep

2022 May 25

Ohara Y, Remillieux MC, Ulrich TJ

196. Neural network-based prediction of the secret-key rate of quantum key distribution.

Sci Rep

2022 May 25

Zhou MG, Liu ZP, Liu WB

197. Heat transfer analysis of Cu and Al(2)O(3) dispersed in ethylene glycol as a base fluid over a stretchable permeable sheet of MHD thin-film flow.

Sci Rep

2022 May 25

Zeeshan, Khan I, Weera W

198. The relationships between physical activity, lumbar multifidus muscle morphology, and low back pain from childhood to early adulthood: a 12-year longitudinal study.

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2022 May 25

Cunningham E, Wedderkopp N, Kjaer P

199. Novel electrochemical PMI marker biosensor based on quantum dot dissolution using a double-label strategy.

Sci Rep

2022 May 25

Jeong B(#), Akter R(#), Oh J

200. Advances in physicochemical characterization of lead-free hybrid perovskite [NH(3)(CH(2))(3)NH(3)]CuBr(4) crystals.

Sci Rep

2022 May 24

Lim AR, Kwac LK.

201. Simultaneous dyeing and antibacterial finishing of polypropylene using vinyl sulfone dye under supercritical carbon dioxide.

Sci Rep

2022 May 24

Abou Elmaaty T, Mousa A, Gaffar H

202. External validation of a triage tool for predicting cardiac arrest in the emergency department.

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2022 May 24

Sun JT, Chang CC, Lu TC

203. DNA and RNA oxidative damage in the retina is associated with ganglion cell mitochondria.

Sci Rep

2022 May 24

Gu L, Kwong JM, Caprioli J

204. Reliability of shear wave elastography for the assessment of gastrocnemius fascia elasticity in healthy individual.

Sci Rep

2022 May 24

Zhou J, Lin Y, Zhang J

The mechanical properties of the deep fascia, particularly their stiffness, strongly affect the development of muscle pathologies (such as compartment syndrome) and the action of the muscles. However, the mechanical characteristics of the deep muscular fascia are still not clearly understood. The present study focuses on examining the reliability of ultrasonic shear wave elastography (USWE) devices in quantifying the shear modulus of the gastrocnemius fascia in healthy individuals, particularly their ability to measure the shear modulus of the deep fascia of the gastrocnemius during ankle dorsiflexion. Twenty-one healthy males (age: 21.48 ± 1.17 years) participated in the study. Using USWE, the shear moduli of the medial gastrocnemius fascia (MGF) and lateral gastrocnemius fascia (LGF) were quantified at different angles during passive lengthening. The two operators took turns measuring each subject's MGF and LGF over a 1-h period, and operator B took an additional measurement 2 h later. For the intra-operator test, the same subjects were measured again at the same time of day 5 days later. Both the intrarater [intraclass correlation coefficient (ICC) = 0.846-0.965)] and interrater (ICC = 0.877-0.961) reliability values for measuring the shear moduli of the MGF and LGF were rated as excellent; the standard error of the mean (SEM) was 3.49 kPa, and the minimal detectable change (MDC) was 9.68 kPa. Regardless of the ankle angle, the shear moduli of the LGF were significantly greater than that of the MGF (p < 0.001). Significant increases in the shear moduli of both the MGF and the LGF were observed in the neutral position compared to the relaxed position. These results indicate that USWE is a reliable technique to assess the shear modulus of the gastrocnemius fascia and detect its dynamic changes during ankle dorsiflexion. USWE can be used for biomechanical studies and intervention experiments concerning the deep fascia.

205. Diversity of the virome associated with alfalfa (Medicago sativa L.) in the U.S. Pacific Northwest.

Sci Rep

2022 May 24

Nemchinov LG, Irish BM, Grinstead S

206. Alteration in DNA-binding affinity of Wilms tumor 1 protein due to WT1 genetic variants associated with steroid - resistant nephrotic syndrome in children.

Sci Rep

2022 May 24

Bezdicka M, Kaufman F, Krizova I

207. Growth differentiation factor 15 as a novel diagnostic and therapeutic marker for autoimmune hepatitis.

Sci Rep

2022 May 24

Arinaga-Hino T, Ide T, Akiba J

Growth differentiation factor 15 (GDF15) has been reported to be associated with fibrosis and cancer in liver disease. Diagnosis of autoimmune hepatitis (AIH) is often difficult because of the lack of specific markers. We investigated whether GDF15 is useful for diagnosing AIH and determined its therapeutic effects. We enrolled 171 Japanese patients as follows: AIH (n = 45), hepatitis B (HB) (n = 17), hepatitis C (HC) (n = 15), primary biliary cholangitis (PBC) (n = 20), and 74 healthy controls. Serum GDF15 levels were measured, and immunohistological analyses of GDF15 were performed using liver tissue of AIH patients. (1) GDF15 levels (pg/ml) were higher in AIH (1994.3 ± 1258.0) and HC (1568.0 ± 822.3) than in HB (953.2 ± 871.4), PBC (643.9 ± 247.0), and controls (475.3 ± 145.3) (p < 0.0001), as well as in cirrhosis patients (n = 31) than in non-cirrhosis patients (n = 66) (1926.6 ± 1026.0 vs. 1249.1 ± 1124.1, p < 0.0001). In non-cirrhosis patients, GDF15 levels were higher in AIH (1914.0 ± 1327.2) than in HC (955.7 ± 502.7), HB (519.3 ± 197.5), and PBC (643.9 ± 247.0) (p < 0.0001). (2) GDF15 was positively correlated with M2BPGi (r = 0.7728), total bilirubin (r = 0.6231), and PT-INR (r = 0.6332). (3) GDF15 levels could be used to distinguish AIH from other liver diseases in non-cirrhosis patients, with an area under the curve of 0.9373 (sensitivity 93.6%, specificity 79.3%, cut-off value 931.3). (4) GDF15 in AIH decreased after treatment. (5) Immunohistological analyses in AIH liver tissues revealed that GDF15 was strongly expressed in inflammatory cells, hepatic cytoplasm, and sinusoidal endothelial cells, but decreased after treatment. GDF15 is a novel diagnostic marker for AIH and is also expected to be a therapeutic marker for AIH.Clinical Trials Registration: The study protocol was approved by the institutional review board of Kurume University (Approval No.: 19049).

208. Sub-second temporal magnetic field microscopy using quantum defects in diamond.

Sci Rep

2022 May 24

Parashar M, Bathla A, Shishir D

209. FXR expression in rats of hilar cholangiocarcinoma.

Sci Rep

2022 May 24

Zhang MY, Luo M, Wang JP.

The study objective was to detect the expression of farnesoid X receptor (FXR) in a rat model of hilar cholangiocarcinoma to provide a new therapeutic target for gene therapy in hilar cholangiocarcinoma. Sixty male Wistar rats (weighing 190 ± 8 g) were randomly divided into three groups (experimental group, control group and sham operation group, 20 rats in each group). The three groups were fed a standard diet. The QBC939 cell suspension of cholangiocarcinoma was injected into the hilar bile duct in the experimental group with a microsyringe. The control group was injected with normal saline, and the sham operation group was not injected with any drugs. A modified tail suspension test (TST) was used to evaluate the mental state and physical activity of rats every day. At 5 weeks, one rat in the experimental group was euthanized, and the changes in the hilar bile duct were recorded. The procedure was repeated at one and half months. After one and half months, hilar cholangiocarcinoma only occurred in the experimental group. Pathological examination confirmed the formation of tumours, and hilar bile duct tissues were taken from the three groups. FXR expression in the hilar bile duct was detected by real-time polymerase chain reaction (RT-PCR) and immunohistochemistry. After two weeks, the rats in the experimental group ate less, and their weight was significantly reduced. One and half months later, hilar cholangiocarcinoma was detected in 16 rats in the experimental group. The levels of alanine aminotransferase and aspartate transaminase in the experimental group were higher than those in the other two groups. The ratio of FXR/GAPDH mRNA was significantly different among the hilar cholangiocarcinoma, control and sham operation groups. Under the light microscope, FXR protein reacted with anti-FXR antibody and showed granular expression. Every pathological section included 4800 cells. A total of 1856 positive cells were in the experimental group, 3279 positive cells were in the control group, and 3371 positive cells were in the sham operation group. FXR expression in the hilar cholangiocarcinoma of rats was significantly lower than that in normal hilar bile duct tissues, suggesting that drugs targeting FXR may be a new strategy for the treatment of hilar cholangiocarcinoma.

210. Comprehensive analysis of 65 patients with Castleman disease in a single center in China.

Sci Rep

2022 May 24

Wang XQ(#), Zhong NN(#), Sun Q(#)

211. Differential effects of acute and chronic antagonist and an irreversible antagonist treatment on cocaine self-administration behavior in rats.

Sci Rep

2022 May 24

Wetzel HN, Tsibulsky VL, Norman AB.

212. Allele expression biases in mixed-ploid sugarcane accessions.

Sci Rep

2022 May 24

Correr FH, Furtado A, Franco Garcia AA

213. Stability analysis of rock slope and calculation of rock lateral pressure in foundation pit with structural plane and cave development.

Sci Rep

2022 May 24

Xu J, Wang Y, Li C.

214. Dominant predictors of early post-transplant outcomes based on the Korean Organ Transplantation Registry (KOTRY).

Sci Rep

2022 May 24

Jeong JC, Koo TY, Ro H

Author information: (1)Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Republic of Korea. (2)Department of Nephrology, Seongnam Citizens Medical Center, Seongnam, Republic of Korea. (3)Department of Internal Medicine, Gil Medical Center, Gachon University College of Medicine, Inchon, Republic of Korea. (4)Division of Nephrology, Medicine, Maryknoll Medical Center, Busan, Republic of Korea. (5)Division of Nephrology, Department of Internal Medicine, Pusan National University School of Medicine, Busan, Republic of Korea. (6)Department of Internal Medicine, Kangdong Sacred Heart Hospital, Hallym University College of Medicine, Seoul, Republic of Korea. (7)Medical Research Collaborating Center, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Republic of Korea. (8)Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea. (9)Department of Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea. (10)Department of Surgery, Yonsei University College of Medicine, Seoul, Republic of Korea. (11)Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea. (12)Department of Internal Medicine, Inje University Busan Paik Hospital, Busan, Republic of Korea. (13)Department of Internal Medicine, Keimyung University School of Medicine, Daegu, Republic of Korea. (14)Department of Surgery, Chonnam National University Medical School, Gwangju, Republic of Korea. (15)Department of Internal Medicine, Jeonbuk National University Medical School, Jeonju, Republic of Korea. (16)Department of Surgery, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Republic of Korea. (17)Transplantation Research Institute, Medical Research Center, Seoul National University College of Medicine, Seoul, Republic of Korea. (18)Korean Organ Transplantation Registry Foundation, 3rd Floor, Myeongryun-gil 22, Jongno-gu, Seoul, Republic of Korea. (19)Laboratory of Transplantation Immunology, Division of Nephrology, Department of Internal Medicine, Severance Hospital, Yonsei University College of Medicine, Room 336, 3rd Floor, 50 Yonsei-ro, Seodaemun-gu, Seoul, 03722, Republic of Korea. jcyjs@yuhs.ac.

215. Energy and economic efficiency of climate-smart agriculture practices in a rice-wheat cropping system of India.

Sci Rep

2022 May 24

Kakraliya SK, Jat HS, Singh I

216. A population genetic analysis of the Critically Endangered Madagascar big-headed turtle, Erymnochelys madagascariensis across captive and wild populations.

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2022 May 24

White NFD, Mennell H, Power G

217. COVID-19 pandemic influence on self-reported health status and well-being in a society.

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2022 May 24

Moniuszko-Malinowska A(#), Czupryna P(#), Dubatówka M

218. Assessment of antimicrobial, cytotoxicity, and antiviral impact of a green zinc oxide/activated carbon nanocomposite.

Sci Rep

2022 May 24

Hassan HS, Abol-Fotouh D, Salama E

219. Prognostic significance of crown-like structures to trastuzumab response in patients with primary invasive HER2 + breast carcinoma.

Sci Rep

2022 May 24

Birts CN(#), Savva C(#), Laversin SA

220. Online recognition and yield estimation of tomato in plant factory based on YOLOv3.

Sci Rep

2022 May 23

Wang X, Vladislav Z, Viktor O

221. Yeast-based directed-evolution for high-throughput structural stabilization of G protein-coupled receptors (GPCRs).

Sci Rep

2022 May 23

Meltzer M, Zvagelsky T, Hadad U

222. Viral strategies for targeting spinal neuronal subtypes in adult wild-type rodents.

Sci Rep

2022 May 23

Kaur J, Berg RW.

223. Response of drought index to land use types in the Loess Plateau of Shaanxi, China.

Sci Rep

2022 May 23

Wang W, Cui C, Yu W

224. An animal derivative-free medium enhances Lactobacillus johnsonii LJO02 supernatant selective efficacy against the methicillin (oxacillin)-resistant Staphylococcus aureus virulence through key-metabolites.

Sci Rep

2022 May 23

Squarzanti DF, Zanetta P, Ormelli M

225. Insecticide resistant Anopheles gambiae have enhanced longevity but reduced reproductive fitness and a longer first gonotrophic cycle.

Sci Rep

2022 May 23

Osoro JK, Machani MG, Ochomo E

Widespread insecticide resistance in African malaria vectors raises concerns over the potential to compromise malaria vector control interventions. Understanding the evolution of resistance mechanisms, and whether the selective disadvantages are large enough to be useful in resistance management or designing suitable control strategies is crucial. This study assessed whether insecticide resistance to pyrethroids has an effect on the gonotrophic cycle and reproductive potential of malaria vector Anopheles gambiae. Comparative tests were performed with pyrethroid-resistant and susceptible colonies of Anopheles gambiae colonized from the same geographical area, and the reference Kisumu strain was used as a control. Adult females aged 3 days old were given a blood meal and kept separately for individual egg-laying. The number of days taken to lay eggs post-blood-feeding was recorded to determine the length of the gonotrophic cycle. To measure adult longevity and reproduction potential, newly emerged males and females of equal numbers were aspirated into a cage and females allowed to blood feed daily. The number of eggs laid and the surviving mosquitoes were recorded daily to determine fecundity, net reproduction rate, intrinsic growth rate and adult longevity. Overall, the resistant females had a significantly longer (1.8 days) gonotrophic cycle than susceptible females (F2, 13 = 9. 836, P < 0.01). The proportion of resistant females that laid eggs was lower 31.30% (94/300) compared to 54% (162/300) in the susceptible colony and 65.7% (197/300) in the Kisumu strain. The mean number of eggs laid per female was significantly lower in the resistant colony (88.02 ± 20) compared to the susceptible colony (104.9 ± .28.8) and the Kisumu strain (97.6 ± 34.8). The adult longevity was significantly higher for resistant (39.7 ± 1.6 days) compared to susceptible (29.9 ± 1.7 days) and the Kisumu strain was (29.6 ± 1.1 days) (F2,8 = 45.05, P < 0.0001). Resistant colony exhibited a lower fecundity (4.3 eggs/females/day) and net reproductive rate (2.6 offsprings/female/generation) compared to the susceptible colony (8.6 eggs/female/day; 4.7 offsprings/female/generation respectively) and Kisumu strain (9.7 eggs/female/day; 4.1 offsprings/female/generation respectively). The study suggests high fitness cost on reproductive parameters of pyrethroid-resistant mosquitoes particularly on the duration of gonotrophic cycle, fecundity and net reproductive rate. These fitness costs are likely associated with maintaining both target site and metabolic mechanisms of resistance to pyrethroids. Despite these costs, resistant mosquitoes had longer longevity. These results give insights to understanding the fitness cost of insecticide resistance and thus are critical when predicting the epidemiological impact of insecticide resistance.

226. Methodology for the determination of human respiration rate by using Doppler radar and Empirical Modal Decomposition.

Sci Rep

2022 May 23

Hernandez-Aguila M, Olvera-Cervantes JL, Perez-Ramos AE

227. Kinetic and thermodynamic study on the esterification of oleic acid over SO(3)H-functionalized eucalyptus tree bark biochar catalyst.

Sci Rep

2022 May 23

Yusuff AS.

228. Multiagent off-screen behavior prediction in football.

Sci Rep

2022 May 23

Omidshafiei S, Hennes D, Garnelo M

In multiagent worlds, several decision-making individuals interact while adhering to the dynamics constraints imposed by the environment. These interactions, combined with the potential stochasticity of the agents' dynamic behaviors, make such systems complex and interesting to study from a decision-making perspective. Significant research has been conducted on learning models for forward-direction estimation of agent behaviors, for example, pedestrian predictions used for collision-avoidance in self-driving cars. In many settings, only sporadic observations of agents may be available in a given trajectory sequence. In football, subsets of players may come in and out of view of broadcast video footage, while unobserved players continue to interact off-screen. In this paper, we study the problem of multiagent time-series imputation in the context of human football play, where available past and future observations of subsets of agents are used to estimate missing observations for other agents. Our approach, called the Graph Imputer, uses past and future information in combination with graph networks and variational autoencoders to enable learning of a distribution of imputed trajectories. We demonstrate our approach on multiagent settings involving players that are partially-observable, using the Graph Imputer to predict the behaviors of off-screen players. To quantitatively evaluate the approach, we conduct experiments on football matches with ground truth trajectory data, using a camera module to simulate the off-screen player state estimation setting. We subsequently use our approach for downstream football analytics under partial observability using the well-established framework of pitch control, which traditionally relies on fully observed data. We illustrate that our method outperforms several state-of-the-art approaches, including those hand-crafted for football, across all considered metrics.

229. Chitosan-EDTA-Cellulose network as a green, recyclable and multifunctional biopolymeric organocatalyst for the one-pot synthesis of 2-amino-4H-pyran derivatives.

Sci Rep

2022 May 23

Rostami N, Dekamin MG, Valiey E

230. iTRAQ proteomics of sentinel lymph nodes for identification of extracellular matrix proteins to flag metastasis in early breast cancer.

Sci Rep

2022 May 22

Pathania S, Khan MI, Bandyopadhyay S

231. Blood compatibility of widely used central venous catheters; an experimental study.

Sci Rep

2022 May 21

Thorarinsdottir H, Kander T, Johansson D

232. Neural network model applied to electromagnetic shielding effectiveness of ultra-light Ni/Cu coated polyester fibrous materials.

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2022 May 21

Periyasamy AP, Muthusamy LP, Militký J.

233. An orally active plant Rubisco-derived peptide increases neuronal leptin responsiveness.

Sci Rep

2022 May 21

Kaneko K(#), Takekuma Y(#), Goto T

234. Expression and function of the luteinizing hormone choriogonadotropin receptor in human endometrial stromal cells.

Sci Rep

2022 May 21

Mann ON, Kong CS, Lucas ES

235. Terahertz waves dynamic diffusion in 3D printed structures.

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2022 May 21

Missori M, Pilozzi L, Conti C.

236. Effect of bending on radial distribution density, MFA and MOE of bent bamboo.

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2022 May 21

Wang X, Ma J, Xu W

237. Refractive astigmatism in phaco-canaloplasty vs phaco-non-penetrating deep sclerectomy.

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2022 May 21

Byszewska A, Rudowicz J, Lewczuk K

This study aimed to assess refractive astigmatism, in phaco-canaloplasty (PC) vs phaco-non-penetrating deep sclerectomy (PDS) in a randomized, prospective study within 24 months. Patients were randomized pre-operatively, 37 underwent PC and 38 PDS. The following data was collected: BCVA, IOP, number of antiglaucoma medications, refraction with autokeratorefractometry. The assessment of astigmatism was simple arithmetic and vector analysis (calculations included cylinder with axis in form of centroids) and included double angle plots and cumulative refractive astigmatism graphs. Pre-operative mean BCVA in PC was 0.40 ± 0.43 and was comparable to BCVA in PDS 0.30 ± 0.32logMAR (P = 0.314). In the sixth month follow-up, mean BCVA showed no difference (P = 0.708) and was 0.07 ± 0.13 and 0.05 ± 0.11, respectively. However, 2 years after the intervention mean BCVA was better in PC 0.05 ± 0.12 than in PDS 0.12 ± 0.23 and it was statistically significant (P = 0.039). Mean astigmatism in PC at baseline was 1.13 ± 0.73Dcyl, at 6 months it was 1.09 ± 0.61 and at 2 years 1.17 ± 0.51. In PDS at baseline 1.35 ± 0.91 at 6 months 1.24 ± 0.86 and at 2 years 1.24 ± 0.82. There were no differences between the groups in mean astigmatism throughout the study. Centroids (mean of a cylinder with axis) in PC were pre-operatively 0.79D@172˚ ± 1.10Dcyl, at 6 months 0.75D@166˚ ± 1.01 and at 24-months 0.64D@164˚ ± 1.11 and in PDS pre-operatively 0.28D@10˚ ± 1.63D at 6 months 0.26D@11˚ ± 1.5 and at 24-months 0.47D@20˚ ± 1.43. The direction of mean astigmatism was against the rule in all analyzed time points. The mean baseline IOP in PC was 19.4 ± 5.8 mmHg and 19.7 ± 5.4 mmHg in PDS(P = 0.639). From the 6-month IOP was lower in PC, at 24-months it was 13.8 ± 3.3 mmHg in PC and 15.1 ± 2.9 mmHg in PDS(P = 0.048). In both groups preoperatively patients used median(Me) of three antiglaucoma medications(P = 0.197), at 24-months in PC mean 0.5 ± 0.9 Me = 0.0 and 1.1 ± 1.2 Me = 1.0 in PDS(P = 0.058). Both surgeries in mid-term observation are safe and effective. They do not generate vision-threatening astigmatism and do not even change the preoperative direction of mean astigmatism. Refractive astigmatism is stable throughout the observation.

238. Design of a cryptographically secure pseudo random number generator with grammatical evolution.

Sci Rep

2022 May 21

Ryan C(#), Kshirsagar M(#), Vaidya G(#)

239. Repetitive afterglow in zirconia by pulsed near-infrared irradiation toward biological temperature sensing.

Sci Rep

2022 May 21

Ohashi M, Takahashi Y, Terakado N

240. A novel spiral infinity reactor for continuous hydrothermal synthesis of nanoparticles.

Sci Rep

2022 May 21

Pukkella AK, Nadimpalli NRV, Runkana V

241. A longitudinal study of the impact of university student return to campus on the SARS-CoV-2 seroprevalence among the community members.

Sci Rep

2022 May 21

Arnold CRK(#), Srinivasan S(#), Rodriguez S

242. Rising surface pressure over Tibetan Plateau strengthens indian summer monsoon rainfall over northwestern India.

Sci Rep

2022 May 21

Singh R, Jaiswal N, Kishtawal CM.

243. Spin-orbit coupling effects on transport properties of electronic Lieb lattice in the presence of magnetic field.

Sci Rep

2022 May 20

Sadeghi E, Rezania H.

244. Selection of RNA-based evaluation methods for tumor microenvironment by comparing with histochemical and flow cytometric analyses in gastric cancer.

Sci Rep

2022 May 20

Saito N, Sato Y, Abe H

245. Proof of concept for multiplex amplicon sequencing for mutation identification using the MinION nanopore sequencer.

Sci Rep

2022 May 20

Whitford W, Hawkins V, Moodley KS

Rapid, cost-effective identification of genetic variants in small candidate genomic regions remains a challenge, particularly for less well equipped or lower throughput laboratories. The application of Oxford Nanopore Technologies' MinION sequencer has the potential to fulfil this requirement. We demonstrate a proof of concept for a multiplexing assay that pools PCR amplicons for MinION sequencing to enable sequencing of multiple templates from multiple individuals, which could be applied to gene-targeted diagnostics. A combined strategy of barcoding and sample pooling was developed for simultaneous multiplex MinION sequencing of 100 PCR amplicons. The amplicons are family-specific, spanning a total of 30 loci in DNA isolated from 82 human neurodevelopmental cases and family members. The target regions were chosen for further interrogation because a potentially disease-causative variant had been identified in affected individuals following Illumina exome sequencing. The pooled MinION sequences were deconvoluted by aligning to custom references using the minimap2 aligner software. Our multiplexing approach produced an interpretable and expected sequence from 29 of the 30 targeted genetic loci. The sequence variant which was not correctly resolved in the MinION sequence was adjacent to a five nucleotide homopolymer. It is already known that homopolymers present a resolution problem with the MinION approach. Interestingly despite equimolar quantities of PCR amplicon pooled for sequencing, significant variation in the depth of coverage (127×-19,626×; mean = 8321×, std err = 452.99) was observed. We observed independent relationships between depth of coverage and target length, and depth of coverage and GC content. These relationships demonstrate biases of the MinION sequencer for longer templates and those with lower GC content. We demonstrate an efficient approach for variant discovery or confirmation from short DNA templates using the MinION sequencing device. With less than 130 × depth of coverage required for accurate genotyping, the methodology described here allows for rapid highly multiplexed targeted sequencing of large numbers of samples in a minimally equipped laboratory with a potential cost as much 200 × less than that from Sanger sequencing.

246. Spatial distribution and risk assessments due to the microplastics pollution in sediments of Karnaphuli River Estuary, Bangladesh.

Sci Rep

2022 May 20

Rakib MRJ(#), Hossain MB(#), Kumar R

247. All-optical manipulation of the Drosophila olfactory system.

Sci Rep

2022 May 20

Zanon M, Zanini D, Haase A.

248. Formation control for discrete-time multi-agent system with input and output delays under network attacks.

Sci Rep

2022 May 20

Yuan J, Liu H, Zhang W.

249. Irregular shape as an independent predictor of prognosis in patients with primary intracerebral hemorrhage.

Sci Rep

2022 May 20

Liu C(#), Zhang H(#), Wang L(#)

250. Differences in interaction lead to the formation of different types of insulin amyloid.

Sci Rep

2022 May 20

Mori W, Kawakami R, Niko Y

251. D-galactose-induced aging aggravates obesity-induced bone dyshomeostasis.

Sci Rep

2022 May 20

Imerb N, Thonusin C, Pratchayasakul W

252. Partial oxidation of methane to methanol on boron nitride at near critical acetonitrile.

Sci Rep

2022 May 20

Kapuge TK, Moharreri E, Perera I

253. Post-resonance backward whirl analysis in cracked overhung rotors.

Sci Rep

2022 May 20

Alzarooni T, Al-Shudeifat M, Shiryayev O

254. X-linked palindromic gene families 4930567H17Rik and Mageb5 are dispensable for male mouse fertility.

Sci Rep

2022 May 20

Stark-Dykema ER(#), Dulka EA(#), Gerlinger ER

255. Assessment of mutations on RBD in the Spike protein of SARS-CoV-2 Alpha, Delta and Omicron variants.

Sci Rep

2022 May 20

da Costa CHS(#), de Freitas CAB(#), Alves CN

256. 6-Bromo-2-naphthol from Silene armeria extract sensitizes Acinetobacter baumannii strains to polymyxin.

Sci Rep

2022 May 20

Kang M, Kim W, Lee J

257. First purified recombinant CYP75B including transmembrane helix with unexpected high substrate specificity to (2R)-naringenin.

Sci Rep

2022 May 20

Hausjell J(#), Weissensteiner J(#), Molitor C

258. Convolutional neural network-based reconstruction for positronium annihilation localization.

Sci Rep

2022 May 20

Jegal J, Jeong D, Seo ES

259. Seed priming with selenium and zinc nanoparticles modifies germination, growth, and yield of direct-seeded rice (Oryza sativa L.).

Sci Rep

2022 May 2

Adhikary S, Biswas B, Chakraborty D

260. Bacterial communities associated with silage of different forage crops in Malaysian climate analysed using 16S amplicon metagenomics.

Sci Rep

2022 May 2

Hisham MB, Hashim AM, Mohd Hanafi N

261. Experimental investigation of CO(2) uptake in CO(2) hydrates formation with amino acids as kinetic promoters and its dissociation at high temperature.

Sci Rep

2022 May 19

Srivastava S, Kollemparembil AM, Zettel V

262. Type 2 diabetes mellitus patients' lived experience at a tertiary hospital in Ekiti State, Nigeria.

Sci Rep

2022 May 19

Okurumeh AI, Akpor OA, Okeya OE

263. Prevalence of leptospirosis among patients attending renal and general outpatient clinics in Mulago Hospital, Kampala, Uganda.

Sci Rep

2022 May 19

Wambi R, Worodria W, Muleme J

264. Performance of PROPELLER FSE T(2)WI in reducing metal artifacts of material porcelain fused to metal crown: a clinical preliminary study.

Sci Rep

2022 May 19

Li W(#), Shi J(#), Bian W

265. Low adherence to the guideline for the acute treatment of migraine.

Sci Rep

2022 May 19

Olesen A, Schytz HW, Ostrowski SR

266. Pore structure evolution in andesite rocks induced by freeze-thaw cycles examined by non-destructive methods.

Sci Rep

2022 May 19

Maľa M, Greif V, Ondrášik M.

267. Distribution of invasive versus native whitefly species and their pyrethroid knock-down resistance allele in a context of interspecific hybridization.

Sci Rep

2022 May 19

Taquet A, Jourdan-Pineau H, Simiand C

268. Optimal strategies and cost-benefit analysis of the [Formula: see text]-player weightlifting game.

Sci Rep

2022 May 19

Cuaresma DCN, Chiba E, Tubay JM

269. Combined treatment of graft versus host disease using donor regulatory T cells and ruxolitinib.

Sci Rep

2022 May 19

Rodríguez-Gil A, Escamilla-Gómez V, Nufer M

270. Prevalence of pain in community-dwelling older adults with hypertension in the United States.

Sci Rep

2022 May 19

Li CY(#), Lin WC(#), Lu CY(#)

271. An air quality index prediction model based on CNN-ILSTM.

Sci Rep

2022 May 19

Wang J, Li X, Jin L

272. Temporally modulated one-dimensional leaky-wave holograms.

Sci Rep

2022 May 19

Amini A(#), Oraizi H(#).

273. Comprehensive genome analysis of Lentzea reveals repertoire of polymer-degrading enzymes and bioactive compounds with clinical relevance.

Sci Rep

2022 May 19

Maiti PK, Mandal S.

274. The lysosomal V-ATPase a3 subunit is involved in localization of Mon1-Ccz1, the GEF for Rab7, to secretory lysosomes in osteoclasts.

Sci Rep

2022 May 19

Matsumoto N, Sekiya M, Sun-Wada GH

275. Neuro-molecular characterization of fish cleaning interactions.

Sci Rep

2022 May 19

Ramírez-Calero S, Paula JR, Otjacques E

276. Evaluation of cfDNA as an early detection assay for dense tissue breast cancer.

Sci Rep

2022 May 19

Barbirou M, Miller AA, Gafni E

277. Noise logic with an InGaN/SiN(x)/Si uniband diode photodetector.

Sci Rep

2022 May 19

Song J, Nötzel R.

278. Association of short-term particulate matter exposure with suicide death among major depressive disorder patients: a time-stratified case-crossover analysis.

Sci Rep

2022 May 19

Hwang IY(#), Choi D(#), Kim JA

279. Prediction of protein-protein interaction using graph neural networks.

Sci Rep

2022 May 19

Jha K, Saha S, Singh H.

280. Synthesis and robocasting of YAG xerogel: one-step conversion of ceramics.

Sci Rep

2022 May 19

Flores-Martinez N, Ouamara L, Remondiere F

281. Predicting target-ligand interactions with graph convolutional networks for interpretable pharmaceutical discovery.

Sci Rep

2022 May 19

Ruiz Puentes P(#), Rueda-Gensini L(#), Valderrama N(#)

282. Torsional wave elastography to assess the mechanical properties of the cornea.

Sci Rep

2022 May 19

Torres J, H Faris I, Callejas A

283. Identification of AKIRIN2 as a potential biomarker and correlation with immunotherapy in gastric adenocarcinoma by integrated bioinformatics analysis.

Sci Rep

2022 May 19

Sun S, Chen J, Weng C

284. Noise resilient leaky integrate-and-fire neurons based on multi-domain spintronic devices.

Sci Rep

2022 May 19

Wang C, Lee C, Roy K.

285. Controlling resistive switching behavior in the solution processed SiO(2-x) device by the insertion of TiO(2) nanoparticles.

Sci Rep

2022 May 19

Kwon S, Kim MJ, Lim DH

286. Reliability and generalization of gait biometrics using 3D inertial sensor data and 3D optical system trajectories.

Sci Rep

2022 May 19

Santos G, Tavares T, Rocha A.

287. Recent progress in melting heat phenomenon for bioconvection transport of nanofluid through a lubricated surface with swimming microorganisms.

Sci Rep

2022 May 19

Alqarni MS, Yasmin S, Waqas H

The cooling of numerous microelectronic devices has become a need in today's world. Nanofluids, a novel type of heat transport fluid containing nano-sized particles embedded in a host liquid, were developed a few years ago. Impact of ultra-fine nanoparticles with oil, water, or ethylene glycol produces these fluids. Nano-liquids have a variety of applications, including engine cooling, electronic devices, biomedicine, and the manufacture of thermal exchangers. The main objective of current research article is to scrutinizes theoretically, the effects of axisymmetric magnetohydrodynamic flow of bio-convective nanoliquid through a moving surface in the occurrence of swimming microorganisms. The idea of the envisaged model is improved by considering the consequence of thermal radiation, activation energy with generalized slip effects under convective boundaries. The present analysis is developed in the form of mathematical formulation and then solved numerically. The governing flow equations are transmuted into dimensionless nonlinear ODEs system by compatible similarity transformations and then integrated this so-formulated highly nonlinear problem numerically via bvp4c built-in scheme in MATLAB. The significance of influential parameters versus velocity field, temperature profile, concentration field and motile density of microorganism's profile are examined with the aid of graphs and tabular data. The physical interpretation of outcomes highlight that the velocity receives increment for amplified mixed convection parameter. The thermal profile is found to be reducing with a greater Prandtl number. The concentration profile of nanoparticle boosts up for greater activation energy parameter. The microorganism's profile is reduced via bioconvection Lewis number. This investigation contains the significance of bioconvection phenomenon, thermal radiation, slip effects and activation energy under convective boundary conditions. These impacts are used in axisymmetric, stagnation point flow of bioconvective magnetized nanofluid containing swimming gyrotactic motile microorganisms over a lubricated surface. The present analysis is not yet published.

288. Destructive coastal sea level oscillations generated by Typhoon Maysak in the Sea of Japan in September 2020.

Sci Rep

2022 May 19

Medvedev IP, Rabinovich AB, Šepić J.

289. The hospital environment versus carriage: transmission pathways for third-generation cephalosporin-resistant bacteria in blood in neonates in a low-resource country healthcare setting.

Sci Rep

2022 May 19

Kovacs D, Silago V, Msanga DR

Neonatal bloodstream infections (BSI) can lead to sepsis, with high morbidity and mortality, particularly in low-income settings. The high prevalence of third-generation cephalosporin-resistant organisms (3GC-RO) complicates the management of BSI. Whether BSI is linked to carriage of 3GC-RO, or to acquisition from the hospital environment is important for infection prevention and control, but the relationship remains unclear, especially in low-income settings. At a tertiary hospital in Mwanza, Tanzania, we screened neonatal blood and rectal samples from 200 neonates, and 400 (hospital) environmental samples. We used logistic regression to identify risk factors, and Kolmogorov-Smirnov tests and randomisation analyses to compare distributions of species and resistance patterns to assess potential routes of transmission. We found that BSIs caused by 3GC-RO were frequent (of 59 cases of BSI, 55 were caused by 3GC-RO), as was carriage of 3GC-RO, particularly Escherichia coli, Klebsiella pneumoniae, and Acinetobacter species. In the 28 infants with both a carriage and blood isolate, there were more (4 of 28) isolate pairs of the same species and susceptibility profile than expected by chance (p < 0.05), but most pairs were discordant (24 of 28). Logistic regression models found no association between BSI and carriage with either 3GC-RO or only 3GC-R K. pneumoniae. These analyses suggest that carriage of 3GC-RO is not a major driver of BSI caused by 3GC-RO in this setting. Comparison with environmental isolates showed very similar distributions of species and resistance patterns in the carriage, BSI, and the environment. These similar distributions, a high frequency of Acinetobacter spp. isolations, the lack of strong association between carriage and BSI, together with the high proportion of 3GC-RO in BSI all suggest that these neonates acquire multidrug-resistant carriage and blood isolates directly from the hospital environment.

290. Effects of different dual task training on dual task walking and responding brain activation in older adults with mild cognitive impairment.

Sci Rep

2022 May 19

Kuo HT(#), Yeh NC(#), Yang YR

291. Cannabis consumption and prosociality.

Sci Rep

2022 May 19

Vigil JM, Stith SS, Chanel T.

292. Label-free complete absorption microscopy using second generation photoacoustic remote sensing.

Sci Rep

2022 May 19

Ecclestone BR, Bell K, Sparkes S

293. Microfluidic-assisted synthesis and modeling of stimuli-responsive monodispersed chitosan microgels for drug delivery applications.

Sci Rep

2022 May 19

Sartipzadeh O, Naghib SM, Haghiralsadat F

294. Human induced mesenchymal stem cells display increased sensitivity to matrix stiffness.

Sci Rep

2022 May 19

Gultian KA, Gandhi R, Sarin K

295. Exploring body consciousness of dancers, athletes, and lightly physically active adults.

Sci Rep

2022 May 19

Virtanen N, Tiippana K, Tervaniemi M

296. Modeling of charged-particle multiplicity and transverse-momentum distributions in pp collisions using a DNN.

Sci Rep

2022 May 19

Shokr E, De Roeck A, Mahmoud MA.

297. Discovery of Late Triassic bivalves from Jurassic deep-water deposits in Riganpeicuo area, Tibet and their geological significance.

Sci Rep

2022 May 18

Xiao H, Luo S, Gao J

298. Results of screening in early and advanced thoracic malignancies in the EORTC pan-European SPECTAlung platform.

Sci Rep

2022 May 18

Morfouace M(#), Novello S(#), Stevovic A(#)

299. Kendall transformation brings a robust categorical representation of ordinal data.

Sci Rep

2022 May 18

Kursa MB.

300. Genetic variation and structure of complete chloroplast genome in alien monoecious and dioecious Amaranthus weeds.

Sci Rep

2022 May 18

Xu H, Xiang N, Du W

301. Assessing the pathogenicity of gut bacteria associated with tobacco caterpillar Spodoptera litura (Fab.).

Sci Rep

2022 May 18

Devi S, Saini HS, Kaur S.

302. NMR-based metabolomic profiling can differentiate follicular lymphoma from benign lymph node tissues and may be predictive of outcome.

Sci Rep

2022 May 18

Banoei MM(#), Mahé E(#), Mansoor A

303. Graph Ricci curvatures reveal atypical functional connectivity in autism spectrum disorder.

Sci Rep

2022 May 18

Elumalai P(#), Yadav Y(#), Williams N

304. Incremental levels of diagnostic information incentivize health-seeking in non-alcoholic fatty liver: a randomized clinical trial.

Sci Rep

2022 May 18

Chavez-Tapia NC, Barrientos-Gutierrez T, Torres-Ibarra L

305. Achieving high molecular alignment and orientation for CH[Formula: see text]F through manipulation of rotational states with varying optical and THz laser pulse parameters.

Sci Rep

2022 May 18

Chordiya K(#), Simkó I(#), Szidarovszky T

306. Modeling the systemic risks of COVID-19 on the wildland firefighting workforce.

Sci Rep

2022 May 18

Belval EJ(#), Bayham J(#), Thompson MP

Wildfire management in the US relies on a complex nationwide network of shared resources that are allocated based on regional need. While this network bolsters firefighting capacity, it may also provide pathways for transmission of infectious diseases between fire sites. In this manuscript, we review a first attempt at building an epidemiological model adapted to the interconnected fire system, with the aims of supporting prevention and mitigation efforts along with understanding potential impacts to workforce capacity. Specifically, we developed an agent-based model of COVID-19 built on historical wildland fire assignments using detailed dispatch data from 2016-2018, which form a network of firefighters dispersed spatially and temporally across the US. We used this model to simulate SARS-CoV-2 transmission under several intervention scenarios including vaccination and social distancing. We found vaccination and social distancing are effective at reducing transmission at fire incidents. Under a scenario assuming High Compliance with recommended mitigations (including vaccination), infection rates, number of outbreaks, and worker days missed are effectively negligible, suggesting the recommended interventions could successfully mitigate the risk of cascading infections between fires. Under a contrasting Low Compliance scenario, it is possible for cascading outbreaks to emerge leading to relatively high numbers of worker days missed. As the model was built in 2021 before the emergence of the Delta and Omicron variants, the modeled viral parameters and isolation/quarantine policies may have less relevance to 2022, but nevertheless underscore the importance of following basic prevention and mitigation guidance. This work could set the foundation for future modeling efforts focused on mitigating spread of infectious disease at wildland fire incidents to manage both the health of fire personnel and system capacity.

307. Tension experience induced by tonal and melodic shift at music phrase boundaries.

Sci Rep

2022 May 18

Zhang N, Sun L, Wu Q

308. Morphological and ultrasonographic characterization of the three zones of supratesticular region of testicular artery in Assaf rams.

Sci Rep

2022 May 18

Hassan MAA(#), Sayed RKA(#), Abdelsabour-Khalaf M

309. Distance to public transit predicts spatial distribution of dengue virus incidence in Medellín, Colombia.

Sci Rep

2022 May 18

Shragai T, Pérez-Pérez J, Del Pilar Quimbayo-Forero M

310. Consideration of high-quality development strategies for soil and water conservation on the loess plateau.

Sci Rep

2022 May 18

Zhang J, Ge Y, Yuan G

311. Plasma levels of S100B and neurofilament light chain protein in stress-related mental disorders.

Sci Rep

2022 May 18

Wallensten J, Mobarrez F, Åsberg M

312. Association between sperm mitochondrial DNA copy number and deletion rate and industrial air pollution dynamics.

Sci Rep

2022 May 18

Vozdova M, Kubickova S, Kopecka V

313. Spatial and temporal distribution of population in urban agglomerations changes in China.

Sci Rep

2022 May 18

Lyu Y, Jiang F.

314. Stratification at the health district level for targeting malaria control interventions in Mali.

Sci Rep

2022 May 18

Cissoko M, Magassa M, Sanogo V

315. Stretchable nanofibers of polyvinylidenefluoride (PVDF)/thermoplastic polyurethane (TPU) nanocomposite to support piezoelectric response via mechanical elasticity.

Sci Rep

2022 May 18

Shehata N, Nair R, Boualayan R

316. No alteration of back muscle oxygenation during isometric exercise in individuals with non-specific low back pain.

Sci Rep

2022 May 18

Langenfeld A, Wirth B, Scherer-Vrana A

317. Antimicrobial potential and osteoblastic cell growth on electrochemically modified titanium surfaces with nanotubes and selenium or silver incorporation.

Sci Rep

2022 May 18

Staats K, Pilz M, Sun J

Titanium nanotube surfaces containing silver, zinc, and copper have shown antimicrobial effects without decreasing osteoblastic cell growth. In this in-vitro study we present first results on the biological evaluation of surface modifications by incorporating selenium and silver compounds into titanium-dioxide (TiO2) nanotubes by electrochemical deposition. TiO2-nanotubes (TNT) and Phosphate-doped TNT (pTNT) were grown on the surface of Ti6Al4V discs by anodization. Hydroxyapatite (HA), selenium (Se) and silver (Ag) compounds were incorporated by electrochemical deposition. Colony forming units of Staphylococcus epidermidis (DSM 3269) were significantly decreased in SepTNT (0.97 ± 0.18 × 106 CFU/mL), SepTNT-HA (1.2 ± 0.39 × 106 CFU/mL), AgpTNT (1.36 ± 0.42 × 106 CFU/mL) and Ag2SepTNT (0.999 ± 0.12 × 106 CFU/mL) compared to the non-modified control (2.2 ± 0.21 × 106 CFU/mL). Bacterial adhesion was calculated by measuring the covered area after fluorescence staining. Adhesion was lower in SepTNT (37.93 ± 12%; P = 0.004), pTNT (47.3 ± 6.3%, P = 0.04), AgpTNT (24.9 ± 1.8%; P < 0.001) and Ag2SepTNT (14.9 ± 4.9%; P < 0.001) compared to the non-modified control (73.7 ± 11%). Biofilm formation and the growth of osteoblastic cells (MG-63) was observed by using Crystal Violet staining. Biofilm formation was reduced in SepTNT (22 ± 3%, P = 0.02) and Ag2SepTNT discs (23 ± 11%, P = 0.02) compared to the non-modified control (54 ± 8%). In comparison with the non-modified control the modified SepTNT-HA and pTNT surfaces showed a significant higher covered area with osteoblastic MG-63-cells. Scanning electron microscope (SEM) images confirmed findings regarding bacterial and osteoblastic cell growth. These findings show a potential synergistic effect by combining selenium and silver with titanium nanotubes.

318. Shift of the storm surge season in Europe due to climate variability.

Sci Rep

2022 May 17

Roustan JB, Pineau-Guillou L, Chapron B

319. Neutrophil elastase aggravates periodontitis by disrupting gingival epithelial barrier via cleaving cell adhesion molecules.

Sci Rep

2022 May 17

Hiyoshi T, Domon H, Maekawa T

320. Quantum features of nonlinear coupler with competing nonlinearity.

Sci Rep

2022 May 17

Julius R, Ibrahim AMA, Choudhury PK

321. An immune gene signature to predict prognosis and immunotherapeutic response in lung adenocarcinoma.

Sci Rep

2022 May 17

Chen H(#), Lin R(#), Lin W(#)

322. Efficient binary and QAM optical modulation in ultra-compact MZI structures utilizing indium-tin-oxide.

Sci Rep

2022 May 17

Mohammadi-Pouyan S, Miri M, Sheikhi MH.

A design for a CMOS-compatible active waveguide is proposed in which the epsilon-near-zero (ENZ) property of the indium-tin-oxide (ITO) is used to induce large variations in the real and imaginary parts of the waveguide effective index. The proposed waveguide comprises a TiN/HfO2/ITO metal-oxide-semiconductor (MOS) structure where the speed and power consumption are significantly improved by the application of the TiN and realization of double accumulation layers in the ITO. Simulations show the insertion loss (IL) of 0.38 dB/μm, extinction ratio (ER) of 11 dB/μm, the energy consumption of 11.87fJ/bit and electrical bandwidth of 280 GHz when the designed waveguide is used as an electro-absorption modulator. The waveguide is then used in an MZI structure to design binary and quadrature-amplitude-modulator (QAM) modulators. For binary modulator, the IL, ER, and VπLπ figures of merit are found to be 1.24 dB, 54 dB, and 6.4 V μm, respectively, which show substantial improvement over previous ITO-based designs. In the QAM design, the symmetry in the real and imaginary parts of the waveguide effective index is employed to obviate the need for additional phase shift elements. This considerably reduces the overall length of the proposed QAM modulator and improves efficiency. Simulations show the energy consumption and bit rate, of 2fJ/bit and 560 Gbps, respectively in a 4-QAM modulator with the overall length of 6.2 μm. The symmetry properties of the proposed waveguide can be further exploited to realize quadrature-phase-shift-keying (QPSK) modulators which here is used in combination with the 4-QAM to propose a design for the more advanced modulation scheme of 16-QAM. The design of ITO-based QAM modulators is here reported for the first time and the abovementioned performance parameters show the unique properties of these modulators in terms of footprint, energy consumption and modulation-speed.

323. Predefined and data driven CT densitometric features predict critical illness and hospital length of stay in COVID-19 patients.

Sci Rep

2022 May 17

Shalmon T, Salazar P, Horie M

324. Property space mapping of Pseudomonas aeruginosa permeability to small molecules.

Sci Rep

2022 May 17

Leus IV, Weeks JW, Bonifay V

325. Network pharmacology combined with GEO database identifying the mechanisms and molecular targets of Polygoni Cuspidati Rhizoma on Peri-implants.

Sci Rep

2022 May 17

Shan C, Ji X, Wu Z

326. Investigating the benthic megafauna in the eastern Clarion Clipperton Fracture Zone (north-east Pacific) based on distribution models predicted with random forest.

Sci Rep

2022 May 17

Uhlenkott K, Simon-Lledó E, Vink A

327. Endocranial volume increases across captive generations in the endangered Mexican wolf.

Sci Rep

2022 May 17

Siciliano-Martina L, Michaud M, Tanis BP

328. Male recognition bias in sex assignment based on visual stimuli.

Sci Rep

2022 May 17

Federici S, Lepri A, Bacci S

329. Piezo2 is not an indispensable mechanosensor in murine cardiomyocytes.

Sci Rep

2022 May 17

Kloth B, Mearini G, Weinberger F

A short-term increase in ventricular filling leads to an immediate (Frank-Starling mechanism) and a slower (Anrep effect) rise in cardiac contractility, while long-term increased cardiac load (e.g., in arterial hypertension) decreases contractility. Whether these answers to mechanical tension are mediated by specific sensors in cardiomyocytes remains elusive. In this study, the piezo2 protein was evaluated as a potential mechanosensor. Piezo2 was found to be upregulated in various rat and mouse cardiac tissues upon mechanical or pharmacological stress. To investigate its function, C57BL/6J mice with homozygous cardiomyocyte-specific piezo2 knockout [Piezo2-KO] were created. To this end, α-MHC-Cre mice were crossed with homozygous "floxed" piezo2 mice. α-MHC-Cre mice crossed with wildtype mice served as controls [WT-Cre+]. In cardiomyocytes of Piezo2-KO mice, piezo2 mRNA was reduced by > 90% and piezo2 protein was not detectable. Piezo2-KO mice displayed no morphological abnormalities or altered cardiac function under nonstressed conditions. In a subsequent step, hearts of Piezo2-KO or WT-Cre+-mice were stressed by either three weeks of increased afterload (angiotensin II, 2.5 mg/kg/day) or one week of hypercontractility (isoprenaline, 30 mg/kg/day). As expected, angiotensin II treatment in WT-Cre+-mice resulted in higher heart and lung weight (per body weight, + 38%, + 42%), lower ejection fraction and cardiac output (- 30%, - 39%) and higher left ventricular anterior and posterior wall thickness (+ 34%, + 37%), while isoprenaline led to higher heart weight (per body weight, + 25%) and higher heart rate and cardiac output (+ 24%, + 54%). The Piezo2-KO mice reacted similarly with the exception that the angiotensin II-induced increases in wall thickness were blunted and the isoprenaline-induced increase in cardiac output was slightly less pronounced. As cardiac function was neither severely affected under basal nor under stressed conditions in Piezo2-KO mice, we conclude that piezo2 is not an indispensable mechanosensor in cardiomyocytes.

330. Cytotoxic and antimicrobial activities of two new sesquiterpenoids from red sea brittle star Ophiocoma dentata.

Sci Rep

2022 May 17

El Feky SE, Abd El Hafez MSM, Abd El Moneim NA

331. Use of intravascular ultrasound and long-term cardiac death or myocardial infarction in patients receiving current generation drug-eluting stents.

Sci Rep

2022 May 17

Lee SY(#), Choi KH(#), Song YB

332. Superposition of vortex beams generated by polarization conversion in uniaxial crystals.

Sci Rep

2022 May 17

Craciun A(#), Grigore OV(#).

333. Assessment of major centelloside ratios in Centella asiatica accessions grown under identical ecological conditions, bioconversion clues and identification of elite lines.

Sci Rep

2022 May 17

Kunjumon R, Johnson AJ, Sukumaryamma Remadevi RK

334. The isolation and expression analysis of cinnamate 4-hydroxylase and chalcone synthase genes of Scrophularia striata under different abiotic elicitors.

Sci Rep

2022 May 17

Rostami Z, Fazeli A, Hojati Z.

335. Acute effects of high intensity training on cardiac function: a pilot study comparing subjects with type 2 diabetes to healthy controls.

Sci Rep

2022 May 17

Ness HO, Ljones K, Gjelsvik RH

336. Clinico-epidemiology and management of hump-nosed pit viper (Hypnale spp.) bites in dogs.

Sci Rep

2022 May 17

Adhikari R, Suriyagoda L, Premarathna AD

Human envenoming from the bite of the abundant hump-nosed pit viper (Hypnale spp.) (HNPV) is a frequent occurrence with victims experiencing unpleasant and sometimes life-threatening consequences. Further, clinico-pathology, treatment and management measures in HNPV envenomed dogs are under recognized. Prospective investigations were performed to assess the clinico-pathology and management options for HNPV envenomed dogs brought to the University of Peradeniya's Veterinary Teaching Hospital from January, 2012 to March 2018. We recorded the local and systemic manifestations, hematological and urinary abnormalities of 78 dogs in which HNPV bite had been witnessed by the owner. Mild swelling, extensive swelling, hemorrhagic blistering and hemorrhagic bullae at the site of bite were observed in 59%, 31%, 6% and 4% of the dogs, respectively. Some dogs were subjected to surgical excision of necrotized tissue including limb amputation. We observed the following systemic clinical effects in envenomed dogs: neurotoxicity (13%), acute kidney injury (AKI) (14%) and coagulopathy (16%). All dogs showed leukocytosis with mean white blood cell count of 25.25 × 103/µL. Mild anemia and thrombocytopenia were detected in 29% of the dogs. There was a significant correlation between extent of local tissue injuries with length of hospitalization (LH). The mean time of coagulopathy observed was 21.3 h (IQR: 8-48 h). In coagulopathic dogs, there was a strong correlation between LH and extent of local tissue injury (rs = 0.7751, P < 0.0001); LH and whole blood clotting time(CT) (rs = 1.0, P < 0.0001); PT and aPTT (rs = 0.4712, P < 0.001). LH was significantly correlated with the development of AKI (p = 0.0013). Lack of specific antivenom (AVS) for HNPV envenoming provided an opportunity to study the remaining treatment options. Therefore, the study allowed the identification of local and systemic effects, hematological abnormalities, possible supportive treatments and drawbacks of management measures for envenomed dogs.

337. Chasing genetic correlation breakers to stimulate population resilience to climate change.

Sci Rep

2022 May 17

Klápště J, Telfer EJ, Dungey HS

Global climate change introduces new combinations of environmental conditions, which is expected to increase stress on plants. This could affect many traits in multiple ways that are as yet unknown but will likely require the modification of existing genetic relationships among functional traits potentially involved in local adaptation. Theoretical evolutionary studies have determined that it is an advantage to have an excess of recombination events under heterogeneous environmental conditions. Our study, conducted on a population of radiata pine (Pinus radiata D. Don), was able to identify individuals that show high genetic recombination at genomic regions, which potentially include pleiotropic or collocating QTLs responsible for the studied traits, reaching a prediction accuracy of 0.80 in random cross-validation and 0.72 when whole family was removed from the training population and predicted. To identify these highly recombined individuals, a training population was constructed from correlation breakers, created through tandem selection of parents in the previous generation and their consequent mating. Although the correlation breakers showed lower observed heterogeneity possibly due to direct selection in both studied traits, the genomic regions with statistically significant differences in the linkage disequilibrium pattern showed higher level of heretozygosity, which has the effect of decomposing unfavourable genetic correlation. We propose undertaking selection of correlation breakers under current environmental conditions and using genomic predictions to increase the frequency of these 'recombined' individuals in future plantations, ensuring the resilience of planted forests to changing climates. The increased frequency of such individuals will decrease the strength of the population-level genetic correlations among traits, increasing the opportunity for new trait combinations to be developed in the future.

338. Identification of candidate genes associated with bacterial and viral infections in wild boars hunted in Tuscany (Italy).

Sci Rep

2022 May 17

Fabbri MC, Crovetti A, Tinacci L

339. Overnutrition is a significant component of food waste and has a large environmental impact.

Sci Rep

2022 May 17

Franco S, Barbanera M, Moscetti R

340. Developmental differences in the impact of perceptual salience on short-term memory performance and meta-memory skills.

Sci Rep

2022 May 17

Pedale T, Mastroberardino S, Capurso M

341. Biomimetic on-chip filtration enabled by direct micro-3D printing on membrane.

Sci Rep

2022 May 17

Li H, Raza A, Yuan S

342. Fundamental aspects of long-acting tenofovir alafenamide delivery from subdermal implants for HIV prophylaxis.

Sci Rep

2022 May 17

Gunawardana M, Remedios-Chan M, Sanchez D

343. White blood cell count is not associated with flow-mediated vasodilation or nitroglycerine-induced vasodilation.

Sci Rep

2022 May 17

Kishimoto S, Maruhashi T, Kajikawa M

344. Delayed processing of blood samples impairs the accuracy of mRNA-based biomarkers.

Sci Rep

2022 May 17

Wilson C, Dias NW, Pancini S

345. Lithospheric conductors reveal source regions of convergent margin mineral systems.

Sci Rep

2022 May 17

Kirkby A, Czarnota K, Huston DL

346. Interdisk spacing effect on resonant properties of Ge disk lattices on Si substrates.

Sci Rep

2022 May 17

Shklyaev AA, Utkin DE, Tsarev AV

347. Homology directed correction, a new pathway model for point mutation repair catalyzed by CRISPR-Cas.

Sci Rep

2022 May 17

Sansbury BM, Hewes AM, Tharp OM

348. Analysis of rhodopsin G protein-coupled receptor orthologs reveals semiochemical peptides for parasite (Schistosoma mansoni) and host (Biomphalaria glabrata) interplay.

Sci Rep

2022 May 17

Phan P, Liang D, Zhao M

Schistosomiasis is a medically significant disease caused by helminth parasites of the genus Schistosoma. The schistosome life cycle requires chemically mediated interactions with an intermediate (aquatic snail) and definitive (human) host. Blocking parasite development within the snail stage requires improved understanding of the interactions between the snail host and the Schistosoma water-borne free-living form (miracidium). Innovations in snail genomics and aquatic chemical communication provide an ideal opportunity to explore snail-parasite coevolution at the molecular level. Rhodopsin G protein-coupled receptors (GPCRs) are of particular interest in studying how trematode parasites navigate towards their snail hosts. The potential role of GPCRs in parasites makes them candidate targets for new antihelminthics that disrupt the intermediate host life-cycle stages, thus preventing subsequent human infections. A genomic-bioinformatic approach was used to identify GPCR orthologs between the snail Biomphalaria glabrata and miracidia of its obligate parasite Schistosoma mansoni. We show that 8 S. mansoni rhodopsin GPCRs expressed within the miracidial stage share overall amino acid similarity with 8 different B. glabrata rhodopsin GPCRs, particularly within transmembrane domains, suggesting conserved structural features. These GPCRs include an orphan peptide receptor as well as several with strong sequence homologies with rhabdomeric opsin receptors, a serotonin receptor, a sulfakinin (SK) receptor, an allatostatin-A (buccalin) receptor and an FMRFamide receptor. Buccalin and FMRFa peptides were identified in water conditioned by B. glabrata, and we show synthetic buccalin and FMRFa can stimulate significant rates of change of direction and turn-back responses in S. mansoni miracidia. Ortholog GPCRs were identified in S. mansoni miracidia and B. glabrata. These GPCRs may detect similar ligands, including snail-derived odorants that could facilitate miracidial host finding. These results lay the foundation for future research elucidating the mechanisms by which GPCRs mediate host finding which can lead to the potential development of novel anti-schistosome interventions.

349. Helical Indexing in Real Space.

Sci Rep

2022 May 17

Sun C, Gonzalez B, Jiang W.

350. Conventional and digital Ki67 evaluation and their correlation with molecular prognosis and morphological parameters in luminal breast cancer.

Sci Rep

2022 May 17

Pons L, Hernández-León L, Altaleb A

351. (99m)Tc-NTP 15-5 is a companion radiotracer for assessing joint functional response to sprifermin (rhFGF-18) in a murine osteoarthritis model.

Sci Rep

2022 May 17

Briat A, Jacques C, Malige M

352. Terahertz absorption characteristics of ammonium salt solution based on self-sampling microfluidic chip.

Sci Rep

2022 May 17

Meng Q, Qian S, Ding J

353. Expert surgeons and deep learning models can predict the outcome of surgical hemorrhage from 1 min of video.

Sci Rep

2022 May 17

Pangal DJ, Kugener G, Zhu Y

Major vascular injury resulting in uncontrolled bleeding is a catastrophic and often fatal complication of minimally invasive surgery. At the outset of these events, surgeons do not know how much blood will be lost or whether they will successfully control the hemorrhage (achieve hemostasis). We evaluate the ability of a deep learning neural network (DNN) to predict hemostasis control ability using the first minute of surgical video and compare model performance with human experts viewing the same video. The publicly available SOCAL dataset contains 147 videos of attending and resident surgeons managing hemorrhage in a validated, high-fidelity cadaveric simulator. Videos are labeled with outcome and blood loss (mL). The first minute of 20 videos was shown to four, blinded, fellowship trained skull-base neurosurgery instructors, and to SOCALNet (a DNN trained on SOCAL videos). SOCALNet architecture included a convolutional network (ResNet) identifying spatial features and a recurrent network identifying temporal features (LSTM). Experts independently assessed surgeon skill, predicted outcome and blood loss (mL). Outcome and blood loss predictions were compared with SOCALNet. Expert inter-rater reliability was 0.95. Experts correctly predicted 14/20 trials (Sensitivity: 82%, Specificity: 55%, Positive Predictive Value (PPV): 69%, Negative Predictive Value (NPV): 71%). SOCALNet correctly predicted 17/20 trials (Sensitivity 100%, Specificity 66%, PPV 79%, NPV 100%) and correctly identified all successful attempts. Expert predictions of the highest and lowest skill surgeons and expert predictions reported with maximum confidence were more accurate. Experts systematically underestimated blood loss (mean error - 131 mL, RMSE 350 mL, R2 0.70) and fewer than half of expert predictions identified blood loss > 500 mL (47.5%, 19/40). SOCALNet had superior performance (mean error - 57 mL, RMSE 295 mL, R2 0.74) and detected most episodes of blood loss > 500 mL (80%, 8/10). In validation experiments, SOCALNet evaluation of a critical on-screen surgical maneuver and high/low-skill composite videos were concordant with expert evaluation. Using only the first minute of video, experts and SOCALNet can predict outcome and blood loss during surgical hemorrhage. Experts systematically underestimated blood loss, and SOCALNet had no false negatives. DNNs can provide accurate, meaningful assessments of surgical video. We call for the creation of datasets of surgical adverse events for quality improvement research.

354. Low divergent MeV-class proton beam with micrometer source size driven by a few-cycle laser pulse.

Sci Rep

2022 May 16

Singh PK, Varmazyar P, Nagy B

355. Tracking COVID-19 urban activity changes in the Middle East from nighttime lights.

Sci Rep

2022 May 16

Stokes EC, Román MO.

356. Inducing respiratory complex I impairment elicits an increase in PGC1α in ovarian cancer.

Sci Rep

2022 May 16

De Luise M(#), Sollazzo M(#), Lama E(#)

357. Socioecology shapes child and adolescent time allocation in twelve hunter-gatherer and mixed-subsistence forager societies.

Sci Rep

2022 May 16

Lew-Levy S, Reckin R, Kissler SM

358. A machine learning approach to predict resilience and sickness absence in the healthcare workforce during the COVID-19 pandemic.

Sci Rep

2022 May 16

Lieslehto J(#), Rantanen N(#), Oksanen LAH

359. Gain roll-off in cadmium selenide colloidal quantum wells under intense optical excitation.

Sci Rep

2022 May 16

Diroll BT, Brumberg A, Schaller RD.

360. Non-linear relationships between density and demographic traits in three Aedes species.

Sci Rep

2022 May 16

Sauers LA, Hawes KE, Juliano SA.

361. Trophic and immunomodulatory effects of adipose tissue derived stem cells in a preclinical murine model of endometriosis.

Sci Rep

2022 May 16

Hirakawa T, Yotsumoto F, Shirasu N

362. A typology of North Sea oil and gas platforms.

Sci Rep

2022 May 16

Lawrence JM, Fernandes PG.

363. Evidence of carbon-supported porphyrins pyrolyzed for the oxygen reduction reaction keeping integrity.

Sci Rep

2022 May 16

Orellana W, Loyola CZ, Marco JF

364. Development of a system for the automated identification of herbarium specimens with high accuracy.

Sci Rep

2022 May 16

Shirai M(#), Takano A(#), Kurosawa T

365. Photoreceptor distributions, visual pigments and the opsin repertoire of Atlantic halibut (Hippoglossus hippoglossus).

Sci Rep

2022 May 16

Bolstad K, Novales Flamarique I.

366. High expression of lncRNA PELATON serves as a risk factor for the incidence and prognosis of acute coronary syndrome.

Sci Rep

2022 May 16

Chen L, Huang Y.

367. Influence of thread design on anchorage of pedicle screws in cancellous bone: an experimental and analytical analysis.

Sci Rep

2022 May 16

Weidling M, Heilemann M, Schoenfelder S

368. The evaluation of IMERG and ERA5-Land daily precipitation over China with considering the influence of gauge data bias.

Sci Rep

2022 May 16

Xie W, Yi S(#), Leng C(#)

369. In vivo imaging with a fast large-area multiphoton exoscope (FLAME) captures the melanin distribution heterogeneity in human skin.

Sci Rep

2022 May 16

Vicente JR, Durkin A, Shrestha K

Melanin plays a significant role in the regulation of epidermal homeostasis and photoprotection of human skin. The assessment of its epidermal distribution and overall content is of great interest due to its involvement in a wide range of physiological and pathological skin processes. Among several spectroscopic and optical imaging methods that have been reported for non-invasive quantification of melanin in human skin, the approach based on the detection of two-photon excited fluorescence lifetime distinguishes itself by enabling selective detection of melanin with sub-cellular resolution, thus facilitating its quantification while also resolving its depth-profile. A key limitation of prior studies on the melanin assessment based on this approach is their inability to account for the skin heterogeneity due to the reduced field of view of the images, which results in high dispersion of the measurement values. Pigmentation in both normal and pathological human skin is highly heterogeneous and its macroscopic quantification is critical for reliable measurements of the epidermal melanin distribution and for capturing melanin-related sensitive dynamic changes as a response to treatment. In this work, we employ a fast large-area multiphoton exoscope (FLAME), recently developed by our group for clinical skin imaging, that has the ability to evaluate the 3D distribution of epidermal melanin content in vivo macroscopically (millimeter scale) with microscopic resolution (sub-micron) and rapid acquisition rates (minutes). We demonstrate significant enhancement in the reliability of the melanin density and distribution measurements across Fitzpatrick skin types I to V by capturing the intra-subject pigmentation heterogeneity enabled by the large volumetric sampling. We also demonstrate the potential of this approach to provide consistent measurement results when imaging the same skin area at different times. These advances are critical for clinical and research applications related to monitoring pigment modulation as a response to therapies against pigmentary skin disorders, skin aging, as well as skin cancers.

370. Conceptual knowledge shapes visual working memory for complex visual information.

Sci Rep

2022 May 16

Sims CR, Lerch RA, Tarduno JA

371. Light and elevated temperature induced degradation and recovery of gallium-doped Czochralski-silicon solar cells.

Sci Rep

2022 May 16

Winter M, Walter DC, Min B

372. Additive effects of coexisting respiratory comorbidities on overall or respiratory mortality in patients with asthma: a national cohort study.

Sci Rep

2022 May 16

Yeo Y(#), Lee H(#), Ryu J(#)

373. Factors associated with gravity-dependent distribution on chest CT in elderly patients with community-acquired pneumonia: a retrospective observational study.

Sci Rep

2022 May 16

Komiya K(#), Yamamoto T(#), Yoshikawa H

374. Antimicrobial properties of chitosan from different developmental stages of the bioconverter insect Hermetia illucens.

Sci Rep

2022 May 16

Guarnieri A, Triunfo M, Scieuzo C

375. Multiscale mechanical consequences of ocean acidification for cold-water corals.

Sci Rep

2022 May 16

Wolfram U, Peña Fernández M, McPhee S

376. Analysis of particles containing alpha-emitters in stagnant water at torus room of Fukushima Dai-ichi Nuclear Power Station's Unit 2 reactor.

Sci Rep

2022 May 16

Yomogida T, Ouchi K, Oka T

377. New integrated hydrologic approach for the assessment of rivers environmental flows into the Urmia Lake.

Sci Rep

2022 May 16

Mobadersani A, Hosseinzadeh Dalir A, Yasi M

378. Development of a new antigen-based microarray platform for screening and detection of human IgG antibodies against SARS-CoV-2.

Sci Rep

2022 May 16

Burgold-Voigt S, Müller E, Zopf D

379. Cubic-meter scale laboratory fault re-activation experiments to improve the understanding of induced seismicity risks.

Sci Rep

2022 May 15

Oye V, Stanchits S, Babarinde O

380. Effects of drying methods and solvent extraction on quantification of major bioactive compounds in pomegranate peel waste using HPLC.

Sci Rep

2022 May 14

Kumar N, Pratibha, Neeraj

381. Thermo-electrochemical redox flow cycle for continuous conversion of low-grade waste heat to power.

Sci Rep

2022 May 14

Bleeker J, Reichert S, Veerman J

382. Ultrasound-assisted carbon ion dosimetry and range measurement using injectable polymer-shelled phase-change nanodroplets: in vitro study.

Sci Rep

2022 May 14

Toumia Y, Pullia M, Domenici F

383. Factoring semi-primes with (quantum) SAT-solvers.

Sci Rep

2022 May 14

Mosca M, Verschoor SR.

384. Blood pressure and outcome after aneurysmal subarachnoid hemorrhage.

Sci Rep

2022 May 14

Darkwah Oppong M, Steinwasser L, Rieß C

Blood pressure management is crucial in the treatment of patients with aneurysmal subarachnoid hemorrhage (aSAH). Possible association between the blood pressure increase and the risk of delayed cerebral ischemia (DCI) and different systemic complications after aSAH is still a matter of debate. This study aims to elucidate the influence of blood pressure levels on the outcome of aSAH. All consecutive aSAH patients (n = 690) treated between 01/2003 and 06/2016 were included. The mean value of the mean arterial pressure (MAP) during 14 days after ictus was calculated for each individual. According to the institutional standards of vasospasm management, the mean 14 days MAP ≥ 95 mmHg was referred as increased (IMAP) and the patients with and without vasospasm were analyzed separately. Study endpoints were the occurrence of DCI on computed tomography scans, development of cardiac and nephrological complications, and poor outcome 6 months after aSAH (mRS > 2). Associations were tested in univariable/multivariable binary logistic regression analysis. IMAP was documented in 474 (68.7%) cases and was more common in individuals with poor neurological conditions at admission (p < 0.001), severe amount of intracranial blood (p = 0.001) and premorbid hypertension (p < 0.001). IMAP was independently associated with the occurrence of DCI (p = 0.014; aOR = 2.97; 95% CI 1.25-7.09) and poor functional outcome (p = 0.020; aOR = 3.14; 95% CI 1.20-8.22) in patients with vasospasm, but not in counterparts without vasospasm (p = 0.113/p = 0.086). IMAP had no influence on cardiac or nephrological complications. In aSAH individuals with cerebral vasospasm, sustained increase of blood pressure exceeding the therapeutic targets is strongly associated with the risk of DCI and poor outcome. Therefore, such an intrinsic increase of blood pressure might reflect the autoregulatory mechanisms against the impending cerebral ischemia in patients with cerebral vasospasm.Trial registration number: German clinical trial registry (DRKS, Unique identifier: DRKS00008749, 06/09/2015).

385. Spatial-dependent quantum dot-photon entanglement via tunneling effect.

Sci Rep

2022 May 14

Delir Ghaleh Joughi Y, Sahrai M.

386. Glycoprotein nonmetastatic melanoma protein B (GNMPB) as a novel biomarker for cerebral adrenoleukodystrophy.

Sci Rep

2022 May 14

Taghizadeh LA, King CJ, Nascene DR

387. A novel approach to control Botrytis cinerea fungal infections: uptake and biological activity of antifungals encapsulated in nanoparticle based vectors.

Sci Rep

2022 May 14

De Angelis G(#), Simonetti G(#), Chronopoulou L(#)

388. Risk factors associated with preterm birth after IVF/ICSI.

Sci Rep

2022 May 13

Li J(#), Shen J(#), Zhang X

In vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI) is associated with an increased risk of preterm (33rd-37th gestational week) and early preterm birth (20th-32nd gestational week). The underlying general and procedure related risk factors are not well understood so far. 4328 infertile women undergoing IVF/ICSI were entered into this study. The study population was divided into three groups: (a) early preterm birth group (n = 66), (b) preterm birth group (n = 675) and (c) full-term birth group (n = 3653). Odds for preterm birth were calculated by stepwise multivariate logistic regression analysis. We identified seven independent risk factors for preterm birth and four independent risk factors for early preterm birth. Older (> 39) or younger (< 25) maternal age (OR: 1.504, 95% CI 1.108-2.042, P = 0.009; OR: 2.125, 95% CI 1.049-4.304, P = 0.036, respectively), multiple pregnancy (OR: 9.780, 95% CI 8.014-11.935, P < 0.001; OR: 8.588, 95% CI 4.866-15.157, P < 0.001, respectively), placenta previa (OR: 14.954, 95% CI 8.053-27.767, P < 0.001; OR: 16.479, 95% CI 4.381-61.976, P < 0.001, respectively), and embryo reduction (OR: 3.547, 95% CI 1.736-7.249, P = 0.001; OR: 7.145, 95% CI 1.990-25.663, P = 0.003, respectively) were associated with preterm birth and early preterm birth, whereas gestational hypertension (OR: 2.494, 95% CI 1.770-3.514, P < 0.001), elevated triglycerides (OR: 1.120, 95% CI 1.011-1.240, P = 0.030) and shorter activated partial thromboplastin time (OR: 0.967, 95% CI 0.949-0.985, P < 0.001) were associated only with preterm birth. In conclusion, preterm and early preterm birth risk factors in patients undergoing assisted IVF/ICSI are in general similar to those in natural pregnancy. The lack of some associations in the early preterm group was most likely due to the lower number of early preterm birth cases. Only embryo reduction represents an IVF/ICSI specific risk factor.

389. Spatial distribution and source identification for heavy metals in surface sediments of East Dongting Lake, China.

Sci Rep

2022 May 13

Yuan Y, Liu B, Liu H.

390. Modified precordial lead ECG SafOne on electrocardiography recordings.

Sci Rep

2022 May 13

Dewi WN(#), Safri S(#), Rosma IH.

391. The vaginal microbiome and the risk of preterm birth: a systematic review and network meta-analysis.

Sci Rep

2022 May 13

Gudnadottir U, Debelius JW, Du J

392. Influences of dielectric constant and scan rate on hysteresis effect in perovskite solar cell with simulation and experimental analyses.

Sci Rep

2022 May 13

Huang JY, Yang YW, Hsu WH

393. Integrated computational analysis reveals HOX genes cluster as oncogenic drivers in head and neck squamous cell carcinoma.

Sci Rep

2022 May 13

Shenoy US, Morgan R, Hunter K

394. Differential effects of stress-related and stress-unrelated humor in remitted depression.

Sci Rep

2022 May 13

Braniecka A, Wołkowicz I, Orylska A

395. Influence of wafer quality on chip size-dependent efficiency variation in blue and green micro light-emitting diodes.

Sci Rep

2022 May 13

Woo KY, Song HG, Lee K

396. A fusion approach to improve accuracy and estimate uncertainty in cuffless blood pressure monitoring.

Sci Rep

2022 May 13

Landry C, Peterson SD, Arami A.

397. Probing the effect of Ni, Co and Fe doping concentrations on the antibacterial behaviors of MgO nanoparticles.

Sci Rep

2022 May 13

Almontasser A, Parveen A.

398. The breast cancer immune microenvironment is modified by neoadjuvant chemotherapy.

Sci Rep

2022 May 13

Urueña C, Lasso P, Bernal-Estevez D

399. Primary support optimization of large-span and shallow buried hard rock tunnels based on the active support concept.

Sci Rep

2022 May 13

Liu Q, Li Y, Li W

400. Cohort dominance rank and "robbing and bartering" among subadult male long-tailed macaques at Uluwatu, Bali.

Sci Rep

2022 May 13

Peterson JV, Fuentes A, Wandia IN.

401. Shrimp thrombospondin (TSP): presence of O-β1,4 N-acetylglucosamine polymers and its function in TSP chain association in egg extracellular matrix.

Sci Rep

2022 May 13

Magerd S, Senarai T, Thongsum O

402. Quasiparticle dynamics by effective [Formula: see text]-field distortion.

Sci Rep

2022 May 13

Cassiano TSA, de Oliveira Neto PH, E Silva GM.

403. Differential expression analysis of genes and long non-coding RNAs associated with KRAS mutation in colorectal cancer cells.

Sci Rep

2022 May 13

Saliani M, Jalal R, Javadmanesh A.

404. Population-specific association of Clock gene polymorphism with annual cycle timing in stonechats.

Sci Rep

2022 May 13

Justen H, Hasselmann T, Illera JC

405. Experimental evaluation of thermal rectification in a ballistic nanobeam with asymmetric mass gradient.

Sci Rep

2022 May 12

Tavakoli A, Maire J, Brisuda B

406. Modification of the vacuum-steam thawing method of meat by using the initial stage of sublimation dehydration.

Sci Rep

2022 May 12

Kopeć A, Mierzejewska S, Bać A

407. In silico mutational analysis of ACE2 to check the susceptibility of lung cancer patients towards COVID-19.

Sci Rep

2022 May 12

Khalid Z, Khan AT, Alnajjar R

408. Gadoxetic acid-enhanced magnetic resonance imaging predicts hyperbilirubinemia induced by glecaprevir during hepatitis C virus treatment.

Sci Rep

2022 May 12

Okubo H, Atsukawa M, Okubo T

409. Cell fiber-based 3D tissue array for drug response assay.

Sci Rep

2022 May 12

Kato-Negishi M, Sawayama J, Kawahara M

410. Association between tumor (18)F-fluorodeoxyglucose metabolism and survival in women with estrogen receptor-positive, HER2-negative breast cancer.

Sci Rep

2022 May 12

Chae SY(#), Park SH(#), Lee HS

411. Predictors of stress among dentists during the COVID-19 epidemic.

Sci Rep

2022 May 12

Wójcik D, Kutnik J, Szalewski L

412. Age-based spatial distribution of workers is resilient to worker loss in a subterranean termite.

Sci Rep

2022 May 12

Lee SB, Chouvenc T, Mizumoto N

413. A mechanical and simplified model for RC elements subjected to combined shear and axial tension.

Sci Rep

2022 May 12

Deifalla A, Mukhtar FM.

414. Hydrochemical characteristics of surface waters and their relationships to the Kashin-Beck Disease in Longzi County, Tibet.

Sci Rep

2022 May 12

Zha X(#), Tian Y(#), Xiao J

415. Reduced helping intentions are better explained by the attribution of antisocial emotions than by 'infrahumanization'.

Sci Rep

2022 May 12

Enock FE, Over H.

416. Short-term causal effects of common treatments in ambulatory children and young adults with cerebral palsy: three machine learning estimates.

Sci Rep

2022 May 12

Schwartz MH, Ries AJ, Georgiadis AG.

417. Analysis of the coexistence of gaming and viewing activities in Twitch users and their relationship with pathological gaming: a multilayer perceptron approach.

Sci Rep

2022 May 12

Cabeza-Ramírez LJ, Rey-Carmona FJ, Del Carmen Cano-Vicente M

418. Inorganic cesium lead mixed halide based perovskite solar materials modified with functional silver iodide.

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2022 May 12

Eze VO, Carani LB, Majumder H

419. Reconfigurable switching between reflecting/absorbing modes in VO(2) assisted graphene-coated hemispherical dielectric hole arrays.

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2022 May 12

Raad SH.

420. Phylogeography of the veined squid, Loligo forbesii, in European waters.

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2022 May 12

Göpel A, Oesterwind D, Barrett C

The veined squid, Loligo forbesii Steenstrup, 1856, occurs at the European Shelf areas including the Azores and represents a valuable resource for the European commercial fishery in the North East Atlantic. However, very little is known about its population structure and phylogeography. This lack of knowledge also impedes the development of sustainable fishery management for this species. The present study combined the use of two types of markers that retrieve patterns of gene flow in different time spans; the analysis of 16 nuclear microsatellites and sequencing of the mitochondrial cytochrome oxidase subunit I (COI). Whereas the high mutation rate of microsatellites allows the description of recent patterns of connectivity in species, the lower mutation rate of COI provides phylogeographic patterns on a longer timescale. A total of 347 individuals of L. forbesii were investigated from nearly the entire distribution range of the species, including the North East Atlantic Shelf, the Azores and the Mediterranean. Individuals from the Western and Eastern Mediterranean Sea have never been included in a genetic study before. We were able to analyse COI sequences from all 12 sampling areas and define three clades of L. forbesii. Due to our large sampling area, we are presenting 13 COI-haplotypes that were previously unknown. The microsatellite analysis does not include the Azores but three main clades could be identified at the remaining 11 sampling sites. Low FST values indicate gene flow over large geographical distances. However, the genetically significant differences and an additional slight grouping in the microsatellite structure reveal that geographical barriers seem to influence the population structure and reduce gene flow. Furthermore, both markers provide strong evidence that the observed phylogeographic pattern reflects the geographical history of the Azores and the Mediterranean Sea.

421. The impact of pitolisant, an H(3) receptor antagonist/inverse agonist, on perirhinal cortex activity in individual neuron and neuronal population levels.

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2022 May 12

Hirano K, Morishita Y, Minami M

422. Preparation, mechanics and self-sensing performance of sprayed reactive powder concrete.

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2022 May 12

Zhang Y, Wang J, Wang J

423. Significant reduction of carbon stocks and changes of ecosystem service valuation of Indian Sundarban.

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2022 May 12

Bera B, Bhattacharjee S, Sengupta N

424. Partially-covered fractal induced turbulence on fins thermal dissipation.

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2022 May 12

Chew SH, Hoi SM, Tran MV

425. Contrast-enhanced ultrasound (CEUS) in characterization of inconclusive cervical lymph nodes: a meta-analysis and systematic review.

Sci Rep

2022 May 12

Spiesecke P, Neumann K, Wakonig K

426. Understanding the diversity and biogeography of Colombian edible plants.

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2022 May 12

Gori B, Ulian T, Bernal HY

427. Exposure of domestic dogs and cats to ticks (Acari: Ixodida) and selected tick-borne diseases in urban and recreational areas in southern Poland.

Sci Rep

2022 May 12

Kocoń A, Asman M, Nowak-Chmura M

428. Sotatercept analog suppresses inflammation to reverse experimental pulmonary arterial hypertension.

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2022 May 12

Joshi SR, Liu J, Bloom T

429. Effects of rhBMP-2-loaded hydroxyapatite granules/beta-tricalcium phosphate hydrogel (HA/β-TCP/hydrogel) composite on a rat model of caudal intervertebral fusion.

Sci Rep

2022 May 12

Nakagawa S, Okada R, Kushioka J

430. Patterns of functional connectivity alterations induced by alcohol reflect somatostatin interneuron expression in the human cerebral cortex.

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2022 May 12

Ochi R, Ueno F, Sakuma M

431. An innovative antenna array with high inter element isolation for sub-6 GHz 5G MIMO communication systems.

Sci Rep

2022 May 12

Alibakhshikenari M, Virdee BS, Benetatos H

432. Mid-infrared-scanning cavity ring-down CH(2)F(2) detection using electronically tuned Cr:ZnSe laser.

Sci Rep

2022 May 12

Yumoto M, Kawata Y, Wada S.

433. Python-assisted biological knowledge acquisition method to trigger design inspiration.

Sci Rep

2022 May 12

Zha ZM, Zhang H, Aggidis GA.

434. Loneliness inside of the brain: evidence from a large dataset of resting-state fMRI in young adult.

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2022 May 12

Brilliant T D, Takeuchi H, Nouchi R

435. Effect of timing of school enrollment on physical fitness in third graders.

Sci Rep

2022 May 12

Fühner T, Granacher U, Golle K

436. Preliminary outcomes of the surgical navigation system combined with intraoperative three-dimensional C-arm computed tomography for zygomatico-orbital fracture reconstruction.

Sci Rep

2022 May 12

Chu YY, Yang JR, Lai BR

437. Impact of host phonons on interstitial diffusion.

Sci Rep

2022 May 12

Tang C, Sun G, Liu Y.

438. First fluvial archive of the 8.2 and 7.6-7.3 ka events in North Africa (Charef River, High Plateaus, NE Morocco).

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2022 May 11

Depreux B, Berger JF, Lefèvre D

439. Diagnosis of colour vision deficits using eye movements.

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2022 May 11

Taore A, Lobo G, Turnbull PR

440. Parallel MR image reconstruction based on triple cycle optimization.

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2022 May 11

Sheng J, Yin J, Wang L

441. Diagnostic accuracy of keystroke dynamics as digital biomarkers for fine motor decline in neuropsychiatric disorders: a systematic review and meta-analysis.

Sci Rep

2022 May 11

Alfalahi H, Khandoker AH, Chowdhury N

The unmet timely diagnosis requirements, that take place years after substantial neural loss and neuroperturbations in neuropsychiatric disorders, affirm the dire need for biomarkers with proven efficacy. In Parkinson's disease (PD), Mild Cognitive impairment (MCI), Alzheimers disease (AD) and psychiatric disorders, it is difficult to detect early symptoms given their mild nature. We hypothesize that employing fine motor patterns, derived from natural interactions with keyboards, also knwon as keystroke dynamics, could translate classic finger dexterity tests from clinics to populations in-the-wild for timely diagnosis, yet, further evidence is required to prove this efficiency. We have searched PubMED, Medline, IEEEXplore, EBSCO and Web of Science for eligible diagnostic accuracy studies employing keystroke dynamics as an index test for the detection of neuropsychiatric disorders as the main target condition. We evaluated the diagnostic performance of keystroke dynamics across 41 studies published between 2014 and March 2022, comprising 3791 PD patients, 254 MCI patients, and 374 psychiatric disease patients. Of these, 25 studies were included in univariate random-effect meta-analysis models for diagnostic performance assessment. Pooled sensitivity and specificity are 0.86 (95% Confidence Interval (CI) 0.82-0.90, I2 = 79.49%) and 0.83 (CI 0.79-0.87, I2 = 83.45%) for PD, 0.83 (95% CI 0.65-1.00, I2 = 79.10%) and 0.87 (95% CI 0.80-0.93, I2 = 0%) for psychomotor impairment, and 0.85 (95% CI 0.74-0.96, I2 = 50.39%) and 0.82 (95% CI 0.70-0.94, I2 = 87.73%) for MCI and early AD, respectively. Our subgroup analyses conveyed the diagnosis efficiency of keystroke dynamics for naturalistic self-reported data, and the promising performance of multimodal analysis of naturalistic behavioral data and deep learning methods in detecting disease-induced phenotypes. The meta-regression models showed the increase in diagnostic accuracy and fine motor impairment severity index with age and disease duration for PD and MCI. The risk of bias, based on the QUADAS-2 tool, is deemed low to moderate and overall, we rated the quality of evidence to be moderate. We conveyed the feasibility of keystroke dynamics as digital biomarkers for fine motor decline in naturalistic environments. Future work to evaluate their performance for longitudinal disease monitoring and therapeutic implications is yet to be performed. We eventually propose a partnership strategy based on a "co-creation" approach that stems from mechanistic explanations of patients' characteristics derived from data obtained in-clinics and under ecologically valid settings. The protocol of this systematic review and meta-analysis is registered in PROSPERO; identifier CRD42021278707. The presented work is supported by the KU-KAIST joint research center.

442. Perceptually motivated loss functions for computer generated holographic displays.

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2022 May 11

Yang F, Kadis A, Mouthaan R

443. Phase-matched high-order harmonic generation in pre-ionized noble gases.

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2022 May 11

Finke O, Vábek J, Nevrkla M

444. A statistical shape model of soleus muscle morphology in spastic cerebral palsy.

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2022 May 11

Bin Ghouth SG, Williams SA, Reid SL

445. Quantifying firm-level economic systemic risk from nation-wide supply networks.

Sci Rep

2022 May 11

Diem C, Borsos A, Reisch T

446. Biosurfactant production by Bacillus subtilis SL and its potential for enhanced oil recovery in low permeability reservoirs.

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2022 May 11

Wu B, Xiu J, Yu L

447. Microwave treatment of rice bran and its effect on phytochemical content and antioxidant activity.

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2022 May 11

Pokkanta P, Yuenyong J, Mahatheeranont S

448. Effect of instant jasmine rice coating combining Spirulina with edible polymers on physicochemical properties, textural properties and sensory acceptance.

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2022 May 11

Utama-Ang N, Kuatrakul I, Walter P

449. Alpha and beta phylogenetic diversities jointly reveal ant community assembly mechanisms along a tropical elevational gradient.

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2022 May 11

Pérez-Toledo GR, Villalobos F, Silva RR

450. Changes in the urine volatile metabolome throughout growth of transplanted hepatocarcinoma.

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2022 May 11

Kochevalina MY, Bukharina AB, Trunov VG

451. Identification of a biomass unaffected pale green mutant gene in Chinese cabbage (Brassica rapa L. ssp. pekinensis).

Sci Rep

2022 May 11

Zhao Y, Huang S, Wang N

452. LncMIR181A1HG is a novel chromatin-bound epigenetic suppressor of early stage osteogenic lineage commitment.

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2022 May 11

Tye CE, Ghule PN, Gordon JAR

453. Temporary cable force monitoring techniques during bridge construction-phase: the Tajo River Viaduct experience.

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2022 May 11

Gaute-Alonso A, Garcia-Sanchez D, Alonso-Cobo C

454. Foveal hypoplasia and characteristics of optical components in patients with familial exudative vitreoretinopathy and retinopathy of prematurity.

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2022 May 11

Chen PY(#), Kang EY(#), Chen KJ

455. High-throughput analysis of ANRIL circRNA isoforms in human pancreatic islets.

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2022 May 11

MacMillan HJ(#), Kong Y(#), Calvo-Roitberg E

456. The nasal microbiome of predicting bronchopulmonary dysplasia in preterm infants.

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2022 May 11

Xu Y, Huang Y, Shen Z

457. Regression-based gap-filling methods show air temperature reductions and wind pattern changes during the 2019 total eclipse in Chile.

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2022 May 11

Hammann AC, MacDonell S.

458. Late non-fasting plasma glucose predicts cardiovascular mortality independent of hemoglobin A1c.

Sci Rep

2022 May 11

Wang Y, Fang Y.

459. Optimization of hydropower energy generation by 14 robust evolutionary algorithms.

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2022 May 11

Sharifi MR, Akbarifard S, Madadi MR

460. Electron beam evaporation of superconductor-ferromagnet heterostructures.

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2022 May 11

Bromley D, Wright AJ, Jones LAH

461. Postural behavior recognition of captive nocturnal animals based on deep learning: a case study of Bengal slow loris.

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2022 May 11

Lei Y(#), Dong P(#), Guan Y(#)

462. Daily blood pressure profile and blood-brain barrier permeability in patients with cerebral small vessel disease.

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2022 May 11

Dobrynina LA, Shamtieva KV, Kremneva EI

463. Development of a predictive model for luteal phase oocyte retrieval in poor responders undergoing natural cycle IVF.

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2022 May 11

Simopoulou M(#), Galatis D(#), Maziotis E

464. Utilization of additive from waste products with gasoline fuel to operate spark ignition engine.

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2022 May 11

Awad OI, Ali OM, Zhou B

465. Prevalence of anxiety and depressive symptoms in ulcerative colitis patients in Jordan and its relationship to patient-reported disease activity.

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2022 May 10

Abu Sneineh A, Haj Ali S, Al-Masri A

466. Cost-utility analysis on robot-assisted and laparoscopic prostatectomy based on long-term functional outcomes.

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2022 May 10

Lindenberg MA, Retèl VP, van der Poel HG

467. Effect of drought on root exudates from Quercus petraea and enzymatic activity of soil.

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2022 May 10

Staszel K, Lasota J, Błońska E.

468. Bilateral subthalamic nucleus deep brain stimulation for refractory isolated cervical dystonia.

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2022 May 10

Yin F(#), Zhao M(#), Yan X

469. Assessing influences of climate change on highland barley productivity in the Qinghai-Tibet Plateau during 1978-2017.

Sci Rep

2022 May 10

Zhang Z, Lu C.

Grain production is becoming increasingly vulnerable to climate change globally. Highland barley (HB) is the most important cereal crop in the Qinghai-Tibet Plateau (QTP), so assessing HB productivity and its response to climate change could help to understand the capacity of grain production and food security. This study simulated the potential yield of HB annually at 72 meteorological stations for 1978-2017 using the WOFOST model, and then analyzed the spatiotemporal changes of HB potential yield and climatic factors in the growing season. Further, the influence of climate change on HB potential yield was explored in different temperature zones (TZ). Results indicate that the annual average of HB potential yield ranged from 3.5 to 8.1 t/ha in the QTP, and it was averaged at 6.5 t/ha in TZ-3, higher than other zones. From 1978 to 2017, HB potential yield for the whole QTP decreased slightly by 2.1 kg/ha per year, and its change rates were 23.9, 10.1, - 15.9, - 23.8 and - 16.7 kg/ha/year from TZ-1 to TZ-5 (p < 0.05), respectively. In all zones, average (Tave), maximum (Tmax) and minimum temperature (Tmin) showed a significantly warming trend (p < 0.01), and Tmin increased by 0.53, 0.45, 0.44, 0.40 and 0.69 °C per decade, higher than that of Tave and Tmax. However, temperature diurnal range (TDR) and radiation (RA) showed a downward trend, and their decrease rates were far higher in TZ-5 and TZ-3. In TZ-1, ΔTDR was the critical factor to the change in HB potential yield, which would increase by 420.30 kg/ha for 1 °C increase of ΔTDR (p < 0.01). From TZ-2 to TZ-5, ΔRA was the critical factor, but the influence amplitude in terms of the elastic coefficient, decreased from 4.08 to 0.99 (p < 0.01). In addition, other factors such as ΔTmax in TZ-3 and ΔTmin in TZ-4 and TZ-5 also had an important influence on the potential yield. To improve the HB productivity in the QTP, suitable varieties should be developed and introduced to adapt the climate warming in different temperature zones. In addition, efforts are needed to adjust the strategies of fertilizers and irrigation applications.

470. Radiobiological effects of wound fluid on breast cancer cell lines and human-derived tumor spheroids in 2D and microfluidic culture.

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2022 May 10

Jeibouei S(#), Hojat A(#), Mostafavi E

471. Robust and scalable barcoding for massively parallel long-read sequencing.

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2022 May 10

Ezpeleta J, Garcia Labari I, Villanova GV

472. A non-canonical Raf function is required for dorsal-ventral patterning during Drosophila embryogenesis.

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2022 May 10

Lusk JB, Chua EHZ, Kaur P