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1. Clinical feasibility of an advanced neonatal epidermal multiparameter continuous monitoring technology in a large public maternity hospital in Nairobi, Kenya.

Sci Rep

2022 Jul 9

Ginsburg AS, Zandi Nia S, Chomba D

Clinically feasible multiparameter continuous physiological monitoring technologies are needed for use in resource-constrained African healthcare facilities to allow for early detection of critical events and timely intervention for major morbidities in high-risk neonates. We conducted a prospective clinical feasibility study of a novel multiparameter continuous physiological monitoring technology in neonates at Pumwani Maternity Hospital in Nairobi, Kenya. To assess feasibility, we compared the performance of Sibel's Advanced Neonatal Epidermal (ANNE) technology to reference technologies, including Masimo's Rad-97 pulse CO-oximeter with capnography technology for heart rate (HR), respiratory rate (RR), and oxygen saturation (SpO2) measurements and Spengler's Tempo Easy non-contact infrared thermometer for temperature measurements. We evaluated key performance criteria such as up-time, clinical event detection performance, and the agreement of measurements compared to those from the reference technologies in an uncontrolled, real-world setting. Between September 15 and December 15, 2020, we collected and analyzed 503 h of ANNE data from 109 enrolled neonates. ANNE's up-time was 42 (11%) h more for HR, 77 (25%) h more for RR, and 6 (2%) h less for SpO2 compared to the Rad-97. However, ANNE's ratio of up-time to total attached time was less than Rad-97's for HR (0.79 vs 0.86), RR (0.68 vs. 0.79), and SpO2 (0.69 vs 0.86). ANNE demonstrated adequate performance in identifying high and low HR and RR and high temperature events; however, showed relatively poor performance for low SpO2 events. The normalized spread of limits of agreement were 8.4% for HR and 52.2% for RR and the normalized root-mean-square deviation was 4.4% for SpO2. Temperature agreement showed a spread of limits of agreement of 2.8 °C. The a priori-identified optimal limits were met for HR and temperature but not for RR or SpO2. ANNE was clinically feasible for HR and temperature but not RR and SpO2 as demonstrated by the technology's up-time, clinical event detection performance, and the agreement of measurements compared to those from the reference technologies.

2. Transcriptome analysis reveals cell cycle-related transcripts as key determinants of varietal differences in seed size of Brassica juncea.

Sci Rep

2022 Jul 9

Dhaka N, Jain R, Yadav A

3. Genetic diversity and population structure of critically endangered Dactylorhiza hatagirea (D. Don) Soo from North-Western Himalayas and implications for conservation.

Sci Rep

2022 Jul 9

Sharma S(#), Chhabra M(#), Singh SK(#)

Dactylorhiza hatagirea (D. Don) Soo is medicinally important herb, which is widely used in ayurveda, unani, and folk/traditional medicine system to cure diseases. Due to its immense ethno-botanical properties, the trade of D. hatagirea is estimated to be USD 1 billion/year in India. Unfortunately, due to overexploitation of the herb from the wild, has resulted in dwindling of its populations in their natural habitats, which has led to its critically endangered status. Molecular genetic studies are still scarce in D. hatagirea, therefore, in current study, genetic diversity and population structure analysis was carried out of 10 populations (48 individuals) collected from three cold desert regions (2527 m-3533 m amsl) of Himachal Pradesh. Mean observed heterozygosity (Ho) and expected heterozygosity (He) was recorded 0.185 and 0.158. The maximum values for Fst (fixation index) and Nm (gene flow) were recorded 0.945 at locus KSSR14 and 1.547 at locus KSSR 4 respectively. Mean genetic differentiation (Fst) coefficient was estimated to 0.542. Overall, low levels of genetic diversity was recorded in the populations of D. hatagirea, might be due to habitat specificity (alpine meadows ecosystem; humid laden undulating habitat), restricted distribution and high anthropogenic activities. However, two populations viz., Bathad and Rangrik were recorded with high diversity and largest number of private alleles, stipulates that these populations might have high evolutionary significance and response to selection. Dendrogram analysis revealed that the populations of D. hatagirea were clustered into four major clusters, which was supported by Bayesian based STRUCTURE predictions. Clustering pattern of majority individuals of different populations revealed consistency with their geographic origin. Outcomes of current study reveals the status of genetic diversity and population structure of endangered D. hatagirea, which can be futuristically utilised for appropriate planning of conservation strategies.

4. Activation of the Hepcidin-Ferroportin1 pathway in the brain and astrocytic-neuronal crosstalk to counteract iron dyshomeostasis during aging.

Sci Rep

2022 Jul 9

Mezzanotte M, Ammirata G, Boido M

5. Different transcriptional responses by the CRISPRa system in distinct types of heterochromatin in Drosophila melanogaster.

Sci Rep

2022 Jul 9

Ortega-Yáñez A, Cruz-Ruiz S, Vázquez M

6. A flexible IrO(2) membrane for pH sensing.

Sci Rep

2022 Jul 9

Chou SC, Hsieh YC, Cheang WH

7. Vascular injury of immature epiphyses impair stem cell engraftment in cartilage defects.

Sci Rep

2022 Jul 9

Rashidi A, Theruvath AJ, Huang CH

The purpose of our study was to investigate if vascular injury in immature epiphyses affects cartilage repair outcomes of matrix-associated stem cell implants (MASI). Porcine bone marrow mesenchymal stromal stem cells (BMSCs) suspended in a fibrin glue scaffold were implanted into 24 full-thickness cartilage defects (5 mm ø) of the bilateral distal femur of six Göttingen minipigs (n = 12 defects in 6 knee joints of 3 immature pigs; age 3.5-4 months; n = 12 defects in 6 knee joints of 3 mature control pigs; age, 21-28 months). All pigs underwent magnetic resonance imaging (MRI) at 2, 4, 12 (n = 24 defects), and 24 weeks (n = 12 defects). After the last imaging study, pigs were sacrificed, joints explanted and evaluated with VEGF, H&E, van Gieson, Mallory, and Safranin O stains. Results of mature and immature cartilage groups were compared using the Wilcoxon signed-rank test. Quantitative scores for subchondral edema at 2 weeks were correlated with quantitative scores for cartilage repair (MOCART score and ICRS score) at 12 weeks as well as Pineda scores at end of the study, using linear regression analysis. On serial MRIs, mature joints demonstrated progressive healing of cartilage defects while immature joints demonstrated incomplete healing and damage of the subchondral bone. The MOCART score at 12 weeks was significantly higher for mature joints (79.583 ± 7.216) compared to immature joints (30.416 ± 10.543, p = 0.002). Immature cartilage demonstrated abundant microvessels while mature cartilage did not contain microvessels. Accordingly, cartilage defects in immature joints showed a significantly higher number of disrupted microvessels, subchondral edema, and angiogenesis compared to mature cartilage. Quantitative scores for subchondral edema at 2 weeks were negatively correlated with MOCART scores (r = - 0.861) and ICRS scores (r = - 0.901) at 12 weeks and positively correlated with Pineda scores at the end of the study (r = 0.782). Injury of epiphyseal blood vessels in immature joints leads to subchondral bone defects and limits cartilage repair after MASI.

8. Risk factors for glaucoma are reflected in abnormal responses to frequency-doubling technology screening in both normal and glaucoma eyes.

Sci Rep

2022 Jul 9

Iwase A, Tsutsumi T, Fujii M

9. Sleep habits are associated with cognition decline in physically robust, but not in frail participants: a longitudinal observational study.

Sci Rep

2022 Jul 8

Chuang SC, Wu IC, Chang JJ

10. Chronology of embryonic and gonadal development in the Reeves' turtle, Mauremys reevesii.

Sci Rep

2022 Jul 8

Akashi H, Kubota M, Yamamoto H

11. Exploring the molecular interaction of mebendazole with bovine serum albumin using multi-spectroscopic approaches and molecular docking.

Sci Rep

2022 Jul 8

El Gammal RN, Elmansi H, El-Emam AA

12. Nutrient intakes and telomere length of cell-free circulating DNA from amniotic fluid: findings from the Mamma & Bambino cohort.

Sci Rep

2022 Jul 8

Magnano San Lio R, Maugeri A, La Rosa MC

13. Assessment of plant growth promoting bacteria strains on growth, yield and quality of sweet corn.

Sci Rep

2022 Jul 8

Katsenios N, Andreou V, Sparangis P

14. Analysing the effect of gender on the human-machine interaction in level 3 automated vehicles.

Sci Rep

2022 Jul 8

Li S, Blythe P, Zhang Y

15. Evaluation of long-term outcomes associated with extended heavy-silicone oil use for the treatment of inferior retinal detachment.

Sci Rep

2022 Jul 8

Horozoglu F, Sener H, Polat OA

16. Functional characterization of dopamine and norepinephrine transport across the apical and basal plasma membranes of the human placental syncytiotrophoblast.

Sci Rep

2022 Jul 8

Horackova H, Karahoda R, Vachalova V

17. Lack of Cathepsin D in the central nervous system results in microglia and astrocyte activation and the accumulation of proteinopathy-related proteins.

Sci Rep

2022 Jul 8

Suzuki C(#), Yamaguchi J(#), Sanada T

18. Phylogeography of Nasutitermes ephratae (Termitidae: Nasutitermitinae) in neotropical region.

Sci Rep

2022 Jul 8

de Faria Santos A, Cancello EM, Morales AC.

19. Diurnal and semidiurnal internal waves on the southern slope of the Yermak Plateau.

Sci Rep

2022 Jul 8

Wang S(#), Cao A(#), Li Q

20. Simulation of hybridized nanofluids flowing and heat transfer enhancement via 3-D vertical heated plate using finite element technique.

Sci Rep

2022 Jul 8

Hafeez MB, Krawczuk M, Shahzad H

21. Comparison of physiological responses of running on a nonmotorized and conventional motor-propelled treadmill at similar intensities.

Sci Rep

2022 Jul 8

Sousa FAB, Manchado-Gobatto FB, de A Rodrigues N

This study aimed to test the agreement of the incremental test's physiological responses between tethered running on a nonmotorized treadmill (NMT) to matched relative intensities while running on a conventional motorized treadmill (MT). Using a within-subject crossover design, nine male recreational runners (age = 22 ± 5 years; height = 175 ± 6 cm; weight = 68.0 ± 16.6 kg) underwent two test sessions: one was an incremental intensity protocol on an MT; the other was on an instrumented NMT. Intensity thresholds at [Formula: see text]O2max, respiratory compensation point (iRCP), and lactate threshold (iLT) were registered for analysis, together with [Formula: see text]̇O2, [Formula: see text]̇E, ƒR, and blood lactate concentration ([Lac]). Comparisons were based on hypothesis testing (Student's T-test), effect sizes (Cohen's d), ICC, and Bland Altman analysis. Statistical significance was accepted at p < 0.05. Attained [Formula: see text]O2max (MT = 52.2 ± 7.3 mL·kg-1·min-1 vs NMT = 50.1 ± 8.1 mL·kg-1·min-1) and [Formula: see text]̇O2 at iRCP (MT = 46.3 ± 7.2 mL·kg-1·min-1 vs NMT = 42.8 ± 9.3 mL·kg-1·min-1) were not different between ergometers (p = 0.15 and 0.13, respectively), with significant ICCs (0.84 and 0.70, respectively) and Pearson's correlations (r = 0.87 and 0.76, respectively). The [Lac] at iLT presented poor agreement between conditions. Significant correlations were found (r between 0.72 and 0.83) for relative power values of i[Formula: see text]O2max (6.56 ± 1.28 W·kg-1), iRCP (4.38 ± 1.50 W·kg-1), and iLT (4.15 ± 1.29 W·kg-1) related to their counterpart obtained on MT. Results show that running on an NMT offers a higher glycolytic demand under the same relative internal load as running on an MT but with a similar aerobic response and correlated intensity determination.

22. A multi-epitope vaccine designed against blood-stage of malaria: an immunoinformatic and structural approach.

Sci Rep

2022 Jul 8

Atapour A, Vosough P, Jafari S

23. Insights into amino acid fractionation and incorporation by compound-specific carbon isotope analysis of three-spined sticklebacks.

Sci Rep

2022 Jul 8

Hesse T, Nachev M, Khaliq S

24. Neuroimaging features of antiphospholipid antibody-related stroke compared with atrial fibrillation-related stroke.

Sci Rep

2022 Jul 8

Yang W, Kang DW, Kim JM

25. A pair of primers facing at the double-strand break site enables to detect NHEJ-mediated indel mutations at a 1-bp resolution.

Sci Rep

2022 Jul 8

Ijaz F, Nakazato R, Setou M

26. PFKM inhibits doxorubicin-induced cardiotoxicity by enhancing oxidative phosphorylation and glycolysis.

Sci Rep

2022 Jul 8

Zhou M, Sun X, Wang C

27. Nanotube abundance from non-negative matrix factorization of Raman spectra as an example of chemical purity from open source machine learning.

Sci Rep

2022 Jul 8

Flores E, Ouyang J, Lapointe F

28. Comparing stress and behavioral coping strategies during the early stages of the COVID-19 crisis among domestic and overseas Taiwanese.

Sci Rep

2022 Jul 8

Chen CC, Wu HY, Yeh MJ

29. Integrated socio-environmental vulnerability assessment of coastal hazards using data-driven and multi-criteria analysis approaches.

Sci Rep

2022 Jul 8

Tanim AH, Goharian E, Moradkhani H.

30. Leveraging physical intelligence for the self-design of high performance engineering structures.

Sci Rep

2022 Jul 8

Paixão J(#), Sadoulet-Reboul E(#), Foltête E(#)

31. Coverage optimization of soil moisture wireless sensor networks based on adaptive Cauchy variant butterfly optimization algorithm.

Sci Rep

2022 Jul 8

Liang J, Tian M, Liu Y

32. 3D-printed lightweight dorsal skin fold chambers from PEEK reduce chamber-related animal distress.

Sci Rep

2022 Jul 8

Xie W, Lorenz M, Poosch F

33. CyberSco.Py an open-source software for event-based, conditional microscopy.

Sci Rep

2022 Jul 8

Chiron L(#), Le Bec M(#), Cordier C

34. A novel inactivated virus system (InViS) for a fast and inexpensive assessment of viral disintegration.

Sci Rep

2022 Jul 8

Furer LA, Clement P, Herwig G

35. Temporal quality degradation in AI models.

Sci Rep

2022 Jul 8

Vela D, Sharp A, Zhang R

36. Re-do Operation Using a Robotic System due to Locoregional Recurrence after Initial Thyroidectomy for Thyroid Cancer.

Sci Rep

2022 Jul 7

Kim DG(#), Kim K(#), Lee JE

37. Shortcuts to adiabatic population inversion via time-rescaling: stability and thermodynamic cost.

Sci Rep

2022 Jul 7

da Silva Andrade J, da Silva França ÂF, de Lima Bernardo B.

38. General circulation and global heat transport in a quadrupling CO(2) pulse experiment.

Sci Rep

2022 Jul 7

An SI, Park SE, Shin J

39. The global, regional and national burden of stomach cancer and its attributable risk factors from 1990 to 2019.

Sci Rep

2022 Jul 7

Song Y, Liu X, Cheng W

40. Sex-specific cardiometabolic risk markers of left ventricular mass in physically active young adults: the CHIEF heart study.

Sci Rep

2022 Jul 7

Tsai KZ, Liu PY, Huang WC

41. Circulating N-Acetylaspartate does not track brain NAA concentrations, cognitive function or features of small vessel disease in humans.

Sci Rep

2022 Jul 7

Rebelos E, Daniele G, Campi B

42. The impact of spontaneous cough on pleural pressure changes during therapeutic thoracentesis.

Sci Rep

2022 Jul 7

Stecka AM(#), Grabczak EM(#), Michnikowski M

43. A millimeter-scale insight into formation mechanism of lacustrine black shale in tephra deposition background.

Sci Rep

2022 Jul 7

Lin S(#), Hou L(#), Luo X

44. Using the Kriging Correlation for unsupervised feature selection problems.

Sci Rep

2022 Jul 7

Chua CH, Guo M, Huang SF.

45. Phyllanthus amarus shoot cultures as a source of biologically active lignans: the influence of selected plant growth regulators.

Sci Rep

2022 Jul 7

Sparzak-Stefanowska B, Krauze-Baranowska M.

46. Untargeted lipidomic analysis of plasma from obese women submitted to combined physical exercise.

Sci Rep

2022 Jul 7

San Martin R, Brandao CFC, Junqueira-Franco MVM

47. Melting enhancement of PCM in a finned tube latent heat thermal energy storage.

Sci Rep

2022 Jul 7

Ahmed S(#), Abderrahmane A, Saeed AM

48. Characterization of regulatory transcriptional mechanisms in hepatocyte lipotoxicity.

Sci Rep

2022 Jul 7

Pérez-Schindler J, Vargas-Fernández E, Karrer-Cardel B

49. Modeling the impact of indoor relative humidity on the infection risk of five respiratory airborne viruses.

Sci Rep

2022 Jul 7

Aganovic A, Bi Y, Cao G

50. Mesenchymal stem cells promote spermatogonial stem/progenitor cell pool and spermatogenesis in neonatal mice in vitro.

Sci Rep

2022 Jul 7

Önen S, Köse S, Yersal N

Prepubertal cancer treatment leads to irreversible infertility in half of the male patients. Current in vitro spermatogenesis protocols and cryopreservation techniques are inadequate to expand spermatogonial stem/progenitor cells (SSPC) from testicles. Bone marrow derived mesenchymal stem cells (BM-MSC) bearing a close resemblance to Sertoli cells, improved spermatogenesis in animal models. We asked if a co-culture setup supported by syngeneic BM-MSC that contributes to the air-liquid interphase (ALI) could lead to survival, expansion and differentiation of SSPCs in vitro. We generated an ALI platform able to provide a real-time cellular paracrine contribution consisting of syngeneic BM-MSCs to neonatal C57BL/6 mice testes. We aimed to evaluate the efficacy of this culture system on SSPC pool expansion and spermatogenesis throughout a complete spermatogenic cycle by measuring the number of total germ cells (GC), the undifferentiated and differentiating spermatogonia, the spermatocytes and the spermatids. Furthermore, we evaluated the testicular cell cycle phases, the tubular and luminal areas using histochemical, immunohistochemical and flow cytometric techniques. Cultures in present of BM-MSCs displayed survival of ID4(+) spermatogonial stem cells (SSC), expansion of SALL4(+) and OCT4(+) SSPCs, VASA(+) total GCs and Ki67(+) proliferative cells at 42 days and an increased number of SCP3(+) spermatocytes and Acrosin(+) spermatids at 28 days. BM-MSCs increased the percentage of mitotic cells within the G2-M phase of the total testicular cell cycle increased for 7 days, preserved the cell viability for 42 days and induced testicular maturation by enlargement of the tubular and luminal area for 42 days in comparison to the control. The percentage of PLZF(+) SSPCs increased within the first 28 days of culture, after which the pool started to get smaller while the number of spermatocytes and spermatids increased simultaneously. Our findings established the efficacy of syngeneic BM-MSCs on the survival and expansion of the SSPC pool and differentiation of spermatogonia to round spermatids during in vitro culture of prepubertal mice testes for 42 days. This method may be helpful in providing alternative cures for male fertility by supporting in vitro differentiated spermatids that can be used for round spermatid injection (ROSI) to female oocyte in animal models. These findings can be further exploited for personalized cellular therapy strategies to cure male infertility of prepubertal cancer survivors in clinics.

51. Green synthesis of novel stable biogenic gold nanoparticles for breast cancer therapeutics via the induction of extrinsic and intrinsic pathways.

Sci Rep

2022 Jul 7

El-Deeb NM, Khattab SM, Abu-Youssef MA

52. Tripling the light extraction efficiency of a deep ultraviolet LED using a nanostructured p-contact.

Sci Rep

2022 Jul 7

López-Fraguas E, Binkowski F, Burger S

53. Synthetic MRI for stroke: a qualitative and quantitative pilot study.

Sci Rep

2022 Jul 7

André J, Barrit S, Jissendi P.

54. Dual immobilization of magnetite nanoparticles and biosilica within alginate matrix for the adsorption of Cd(II) from aquatic phase.

Sci Rep

2022 Jul 6

Safari M, Rezaee R, Soltani RDC

55. Peptidome profiling for the immunological stratification in sepsis: a proof of concept study.

Sci Rep

2022 Jul 6

Ledesma M, Todero MF, Maceira L

56. Application of multiplex amplicon deep-sequencing (MAD-seq) to screen for putative drug resistance markers in the Necator americanus isotype-1 β-tubulin gene.

Sci Rep

2022 Jul 6

George S, Suwondo P, Akorli J

57. Multivariate analysis methods improve the selection of strawberry genotypes with low cold requirement.

Sci Rep

2022 Jul 6

Barth E, de Resende JTV, Mariguele KH

58. Enrichment of (150)Nd for neutrinoless double-beta decay detection.

Sci Rep

2022 Jul 6

Suryanarayana MV.

59. Rickettsia helvetica infection is associated with microbiome modulation in Ixodes ricinus collected from humans in Serbia.

Sci Rep

2022 Jul 6

Maitre A, Wu-Chuang A, Mateos-Hernández L

Rickettsia helvetica is an emerging pathogen of the Spotted Fever Group Rickettsia (SFGR) causing spotted fever diseases in various European countries. This tick-borne pathogen replicates in tick tissues such as the midgut and salivary gland, but its potential interactions with the vector microbiota is poorly characterized. The vector microbiome plays a pivotal role in tick-pathogen interactions, and some microbiota members facilitate or impede tick-borne pathogen infection. Manipulations of the tick microbiome have led to reduction in pathogen colonization in the tick vector. However, translating these findings into disease control applications requires a thorough characterization of vector microbiota response to different pathogens. In this study, we analyzed and compared the microbiota of Ixodes ricinus ticks attached on humans and collected in Serbia. Ticks were either infected with R. helvetica, or uninfected with major tick-borne pathogens (referred hereafter as 'pathogen-free'). We used microbial co-occurrence network analysis to determine keystone taxa of each set of samples, and to study the interaction patterns of the microbial communities in response to pathogen infection. The inferred functional profiles of the tick microbiome in R. helvetica-positive and pathogen-free samples were also compared. Our results show that R. helvetica infection reduces significantly the diversity of the microbiota and the connectivity of the co-occurrence network. In addition, using co-occurrence network we identified bacterial taxa (i.e., Enterobacteriaceae, Comamonadaceae, and Bacillus) that were negatively associated with 'Rickettsia' in R. helvetica-infected ticks, suggesting competition between R. helvetica and some members of the tick microbiota. The reconstruction of microbial metabolic pathways shows that the presence of R. helvetica might have a major impact on the metabolic functions of the tick microbiome. These results can inform novel interventions for the prevention of R. helvetica, or other SFGR infections in humans.

60. Resilience to suicidal behavior in young adults: a cross-sectional study.

Sci Rep

2022 Jul 6

Han J, Wong I, Christensen H

61. Investigation of cypermethrin toxicity in Swiss albino mice with physiological, genetic and biochemical approaches.

Sci Rep

2022 Jul 6

Seven B, Kültiğin, Çavuşoğlu

62. Two-dimensional B[Formula: see text]C as a potential anode material for Mg-ion batteries with extremely high theoretical capacity.

Sci Rep

2022 Jul 6

Kasprzak GT, Durajski AP.

63. Microfluidic model for in vitro acute Toxoplasma gondii infection and transendothelial migration.

Sci Rep

2022 Jul 6

Kim H(#), Hong SH(#), Jeong HE

64. Baseline predictors of in-hospital mortality after acute traumatic spinal cord injury: data from a level I trauma center.

Sci Rep

2022 Jul 6

Blex C, Kreutzträger M, Ludwig J

65. A unique peptide-based pharmacophore identifies an inhibitory compound against the A-subunit of Shiga toxin.

Sci Rep

2022 Jul 6

Watanabe-Takahashi M(#), Senda M(#), Yoshino R(#)

66. PD-L1 regulates cell proliferation and apoptosis in acute myeloid leukemia by activating PI3K-AKT signaling pathway.

Sci Rep

2022 Jul 6

Wang F(#), Yang L(#), Xiao M

As immune checkpoint inhibitors (ICIs) continue to advance, more evidence has emerged that anti-PD-1/PD-L1 immunotherapy is an effective treatment against cancers. Known as the programmed death ligand-1 (PD-L1), this co-inhibitory ligand contributes to T cell exhaustion by interacting with programmed death-1 (PD-1) receptor. However, cancer-intrinsic signaling pathways of the PD-L1 molecule are not well elucidated. Therefore, the present study aimed to evaluate the regulatory network of PD-L1 and lay the basis of successful use of anti-PD-L1 immunotherapy in acute myeloid leukemia (AML). Data for AML patients were extracted from TCGA and GTEx databases. The downstream signaling pathways of PD-L1 were identified via Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analysis. The key PD-L1 related genes were selected by weighted gene co-expression network analysis (WGCNA), MCC algorithm and Molecular Complex Detection (MCODE). The CCK-8 assay was used to assess cell proliferation. Flow cytometry was used to determine cell apoptosis and cell cycle. Western blotting was used to identify the expression of the PI3K-AKT signaling pathway. PD-L1 was shown to be elevated in AML patients when compared with the control group, and high PD-L1 expression was associated with poor overall survival rate. The ECM-receptor interaction, as well as the PI3K-AKT signaling pathway, were important PD-L1 downstream pathways. All three analyses found eight genes (ITGA2B, ITGB3, COL6A5, COL6A6, PF4, NMU, AGTR1, F2RL3) to be significantly associated with PD-L1. Knockdown of PD-L1 inhibited AML cell proliferation, induced cell apoptosis and G2/M cell cycle arrest. Importantly, PD-L1 knockdown reduced the expression of PI3K and p-AKT, but PD-L1 overexpression increased their expression. The current study elucidates the main regulatory network and downstream targets of PD-L1 in AML, assisting in the understanding of the underlying mechanism of anti-PD-1/PD-L1 immunotherapy and paving the way for clinical application of ICIs in AML.

67. Histological and electrophysiological evidence on the safe operation of a sharp-tip multimodal optrode during infrared neuromodulation of the rat cortex.

Sci Rep

2022 Jul 6

Horváth ÁC(#), Borbély S(#), Mihók F

68. Evaluation of blood perfusion using laser doppler flowmetry during endoscopic lumbar sympathectomy in patients with plantar hyperhidrosis: a retrospective observational study.

Sci Rep

2022 Jul 6

Lee YC, You YK, Lee S

69. A thorough annotation of the krill transcriptome offers new insights for the study of physiological processes.

Sci Rep

2022 Jul 6

Urso I, Biscontin A, Corso D

70. Microsponge based gel as a simple and valuable strategy for formulating and releasing Tazarotene in a controlled manner.

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2022 Jul 6

Khattab A, Nattouf A.

71. The interplay of chemical structure, physical properties, and structural design as a tool to modulate the properties of melanins within mesopores.

Sci Rep

2022 Jul 6

Pira A, Amatucci A, Melis C

The design of modern devices that can fulfil the requirements for sustainability and renewable energy applications calls for both new materials and a better understanding of the mixing of existing materials. Among those, surely organic-inorganic hybrids are gaining increasing attention due to the wide possibility to tailor their properties by accurate structural design and materials choice. In this work, we'll describe the tight interplay between porous Si and two melanic polymers permeating the pores. Melanins are a class of biopolymers, known to cause pigmentation in many living species, that shows very interesting potential applications in a wide variety of fields. Given the complexity of the polymerization process beyond the formation and structure, the full understanding of the melanins' properties remains a challenging task. In this study, the use of a melanin/porous Si hybrid as a tool to characterize the polymer's properties within mesopores gives new insights into the conduction mechanisms of melanins. We demonstrate the dramatic effect induced on these mechanisms in a confined environment by the presence of a thick interface. In previous studies, we already showed that the interactions at the interface between porous Si and eumelanin play a key role in determining the final properties of composite materials. Here, thanks to a careful monitoring of the photoconductivity properties of porous Si filled with melanins obtained by ammonia-induced solid-state polymerization (AISSP) of 5,6-dihydroxyindole (DHI) or 1,8-dihydroxynaphthalene (DHN), we investigate the effect of wet, dry, and vacuum cycles of storage from the freshly prepared samples to months-old samples. A computational study on the mobility of water molecules within a melanin polymer is also presented to complete the understanding of the experimental data. Our results demonstrate that: (a) the hydration-dependent behavior of melanins is recovered in large pores (≈ 60 nm diameter) while is almost absent in thinner pores (≈ 20 nm diameter); (b) DHN-melanin materials can generate higher photocurrents and proved to be stable for several weeks and more sensitive to the wet/dry variations.

72. Effects of a supervised exercise program in addition to electrical stimulation or kinesio taping in low back pain: a randomized controlled trial.

Sci Rep

2022 Jul 6

Aguilar-Ferrándiz ME, Matarán-Peñarrocha GA, Tapia-Haro RM

73. Systematic review of mental health symptom changes by sex or gender in early-COVID-19 compared to pre-pandemic.

Sci Rep

2022 Jul 6

Dal Santo T, Sun Y, Wu Y

Women and gender-diverse individuals have faced disproportionate socioeconomic burden during COVID-19. There have been reports of greater negative mental health changes compared to men based on cross-sectional research that has not accounted for pre-COVID-19 differences. We compared mental health changes from pre-COVID-19 to during COVID-19 by sex or gender. MEDLINE (Ovid), PsycINFO (Ovid), CINAHL (EBSCO), EMBASE (Ovid), Web of Science Core Collection: Citation Indexes, China National Knowledge Infrastructure, Wanfang, medRxiv (preprints), and Open Science Framework Preprints (preprint server aggregator) were searched to August 30, 2021. Eligible studies included mental health symptom change data by sex or gender. 12 studies (10 unique cohorts) were included, all of which reported dichotomized sex or gender data. 9 cohorts reported results from March to June 2020, and 2 of these also reported on September or November to December 2020. One cohort included data pre-November 2020 data but did not provide dates. Continuous symptom change differences were not statistically significant for depression (standardized mean difference [SMD] = 0.12, 95% CI -0.09-0.33; 4 studies, 4,475 participants; I2 = 69.0%) and stress (SMD = - 0.10, 95% CI -0.21-0.01; 4 studies, 1,533 participants; I2 = 0.0%), but anxiety (SMD = 0.15, 95% CI 0.07-0.22; 4 studies, 4,344 participants; I2 = 3.0%) and general mental health (SMD = 0.15, 95% CI 0.12-0.18; 3 studies, 15,692 participants; I2 = 0.0%) worsened more among females/women than males/men. There were no significant differences in changes in proportions above cut-offs: anxiety (difference = - 0.05, 95% CI - 0.20-0.11; 1 study, 217 participants), depression (difference = 0.12, 95% CI -0.03-0.28; 1 study, 217 participants), general mental health (difference = - 0.03, 95% CI - 0.09-0.04; 3 studies, 18,985 participants; I2 = 94.0%), stress (difference = 0.04, 95% CI - 0.10-0.17; 1 study, 217 participants). Mental health outcomes did not differ or were worse by small amounts among women than men during early COVID-19.

74. Impact of COVID-19 on cancer screening in South Korea.

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2022 Jul 5

Lee K, Lee YY, Suh M

75. Chronic social defeat stress increases the amounts of 12-lipoxygenase lipid metabolites in the nucleus accumbens of stress-resilient mice.

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2022 Jul 5

Akiyama S, Nagai H, Oike S

76. Interface modes in planar one-dimensional magnonic crystals.

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2022 Jul 5

Mieszczak S, Kłos JW.

77. A novel Cuproptosis-related LncRNA signature to predict prognosis in hepatocellular carcinoma.

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2022 Jul 5

Zhang G(#), Sun J(#), Zhang X.

78. The evaluation of Bcftools mpileup and GATK HaplotypeCaller for variant calling in non-human species.

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2022 Jul 5

Lefouili M, Nam K.

79. Comprehensive climatic suitability evaluation of peanut in Huang-Huai-Hai region under the background of climate change.

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2022 Jul 5

Wei S, Li K, Yang Y

80. Examination of sub-harmonic responses along with various initial conditions induced by multi-staged clutch damper system.

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2022 Jul 5

Yoon JY, Kim B.

81. Older Korean men with inadequate vitamin D status have lower odds of radiologic osteoarthritis.

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2022 Jul 5

Kim S, Lee GW, Park CY.

82. Prediction of postoperative cardiac events in multiple surgical cohorts using a multimodal and integrative decision support system.

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2022 Jul 5

Kim RB(#), Alge OP(#), Liu G

83. Measurements of roll, steering, and the far-field wake in track cycling.

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2022 Jul 5

Fitzgerald S, Kelso R, Grimshaw P

84. Design and characteristics analysis of a new vibration reduction system for in service long span transmission tower.

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2022 Jul 5

Liu J, Li Z, Liu W

The wind-induced fatigue is the main factor leading to reduction of the bearing capacity of long-span transmission towers. In order to reduce the harm of wind vibration, this paper takes the 500 kV Jiamusi region ISLSTT (in service long span transmission tower) as the research object, and a new kind of vibration reduction system is proposed based on a steel wire rope damping structure, with which the vibration characteristics of ISLSTT is analyzed. Firstly, the layout and components of the new vibration reduction system are described, and the damping performance of which is verified and analyzed by finite element method. Secondly, the nonlinear finite element dynamic simulation model of ISLSTT with the new vibration reduction system is established, and the multi-dimensional fluctuating wind speed time history satisfying Davenport wind speed spectrum is given by harmonic superposition method in the time domain. Based on the Bernoulli theorem, the corresponding time history of wind pressure is obtained, and the random wind load is applied to the finite element model to verify the feasibility and efficient of the new vibration reduction system. Finally, the aero-elastic wind tunnel test model of ISLSTT with the new vibration reduction system is built, and the time history curves of stress and acceleration at key points under different wind directions are obtained. By comparing with the un-damped system, it is demonstrated that the average damping efficiency of this method in the scale of stress and acceleration is 72.88% and 77.17%, respectively. The simulation and wind tunnel test results also demonstrate that the vibration reduction system based on wire rope damping structure can effectively reduce the vibration of ISLSTT caused by the non-uniformity of wind speed. The research results lay a solid foundation for the vibration reduction design of in service long span tower-line system in future.

85. Protection of hamsters challenged with SARS-CoV-2 after two doses of MVC-COV1901 vaccine followed by a single intranasal booster with nanoemulsion adjuvanted S-2P vaccine.

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2022 Jul 5

Lin YJ, Lin MY, Chuang YS

86. Heat stress mitigation in tomato (Solanum lycopersicum L.) through foliar application of gibberellic acid.

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2022 Jul 5

Guo T, Gull S, Ali MM

87. Meeting 24-h movement guidelines and markers of adiposity in adults from eight Latin America countries: the ELANS study.

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2022 Jul 5

Ferrari G, Cristi-Montero C, Drenowatz C

88. Inverse-cavity structure for low-threshold miniature lasers.

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2022 Jul 5

Kim G, Song SH, Yoon JW.

89. Edge-colored directed subgraph enumeration on the connectome.

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2022 Jul 5

Matejek B, Wei D, Chen T

90. Impact of lumbar spinal stenosis on metabolic syndrome incidence in community-dwelling adults in Aizu cohort study (LOHAS).

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2022 Jul 4

Ono R, Takegami M, Yamamoto Y

91. Suitability of the global forest cover change map to assess climatic megadisturbance impacts on remote tropical forests.

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2022 Jul 4

Geler Roffe T, Couturier S, García-Romero A.

92. Counting generations in birth and death processes with competing Erlang and exponential waiting times.

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2022 Jul 4

Belluccini G, López-García M, Lythe G

Lymphocyte populations, stimulated in vitro or in vivo, grow as cells divide. Stochastic models are appropriate because some cells undergo multiple rounds of division, some die, and others of the same type in the same conditions do not divide at all. If individual cells behave independently, then each cell can be imagined as sampling from a probability density of times to division and death. The exponential density is the most mathematically and computationally convenient choice. It has the advantage of satisfying the memoryless property, consistent with a Markov process, but it overestimates the probability of short division times. With the aim of preserving the advantages of a Markovian framework while improving the representation of experimentally-observed division times, we consider a multi-stage model of cellular division and death. We use Erlang-distributed (or, more generally, phase-type distributed) times to division, and exponentially distributed times to death. We classify cells into generations, using the rule that the daughters of cells in generation n are in generation [Formula: see text]. In some circumstances, our representation is equivalent to established models of lymphocyte dynamics. We find the growth rate of the cell population by calculating the proportions of cells by stage and generation. The exponent describing the late-time cell population growth, and the criterion for extinction of the population, differs from what would be expected if N steps with rate [Formula: see text] were equivalent to a single step of rate [Formula: see text]. We link with a published experimental dataset, where cell counts were reported after T cells were transferred to lymphopenic mice, using Approximate Bayesian Computation. In the comparison, the death rate is assumed to be proportional to the generation and the Erlang time to division for generation 0 is allowed to differ from that of subsequent generations. The multi-stage representation is preferred to a simple exponential in posterior distributions, and the mean time to first division is estimated to be longer than the mean time to subsequent divisions.

93. The upper percolation threshold and porosity-permeability relationship in sandstone reservoirs using digital image analysis.

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2022 Jul 4

Payton RL, Chiarella D, Kingdon A.

Subsurface sandstone deposits represent globally ubiquitous reservoirs which can potentially provide the characteristics necessary for the effective geological storage of CO2. Geological carbon storage is widely agreed to be a key asset in tackling anthropogenic emissions and climate change to reach a sustainable 'net zero', despite the present financial challenges associated with it. Therefore, improved understanding of the characteristics of the materials in which we plan to store many gigatons of CO2 is critical. Developing cheaper characterisation techniques is therefore crucial to support the global push for net zero. In this work we use digital analysis of 3D microscale X-ray images of a range of sandstone samples to constrain the porosity-permeability relationship and the upper percolation threshold; the point at which near full pore structure connectivity is achieved. This is one of the most significant controls on the viability of carbon storage as a practical solution to achieving net zero. We find that the upper percolation threshold in sandstone occurs at ca. 14% total porosity whilst the relationship between porosity ([Formula: see text]) and permeability ([Formula: see text]) can be defined as [Formula: see text]. The investigation of the upper percolation threshold may allow a target criterion to be designated when assessing potential carbon storage reservoirs, whilst investigation of the porosity-permeability relationship allows for a greater understanding of the fluid flow regimes in the subsurface. By using a digital technique to assess carbon storage reservoir potentiality we show that initial characterisation of reservoirs can be carried out rapidly and relatively economically, prior to further full reservoir characterisation studies. This approach is also non-destructive, allowing samples to be reused and multiple analytical phases performed on the same materials.

94. A systematic review and meta-analysis on the association between ambient air pollution and pulmonary tuberculosis.

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2022 Jul 4

Dimala CA, Kadia BM.

There is inconclusive evidence on the association between ambient air pollution and pulmonary tuberculosis (PTB) incidence, tuberculosis-related hospital admission and mortality. This review aimed to assess the extent to which selected air pollutants are associated to PTB incidence, hospital admissions and mortality. This was a systematic review of studies published in English from January 1st, 1946, through May 31st, 2022, that quantitatively assessed the association between PM2.5, PM10, NO2, SO2, CO, O3 and the incidence of, hospital admission or death from PTB. Medline, Embase, Scopus and The Cochrane Library were searched. Extracted data from eligible studies were analysed using STATA software. Random-effect meta-analysis was used to derive pooled adjusted risk and odds ratios. A total of 24 studies (10 time-series, 5 ecologic, 5 cohort, 2 case-control, 1 case cross-over, 1 cross-sectional) mainly from Asian countries were eligible and involved a total of 437,255 tuberculosis cases. For every 10 μg/m3 increment in air pollutant concentration, there was a significant association between exposure to PM2.5 (pooled aRR = 1.12, 95% CI: 1.06-1.19, p < 0.001, N = 6); PM10 (pooled aRR = 1.06, 95% CI: 1.01-1.12, p = 0.022, N = 8); SO2 (pooled aRR = 1.08, 95% CI: 1.04-1.12, p < 0.001, N = 9); and the incidence of PTB. There was no association between exposure to CO (pooled aRR = 1.04, 95% CI: 0.98-1.11, p = 0.211, N = 4); NO2 (pooled aRR = 1.08, 95% CI: 0.99-1.17, p = 0.057, N = 7); O3 (pooled aRR = 1.00, 95% CI: 0.99-1.02, p = 0.910, N = 6) and the incidence of PTB. There was no association between the investigated air pollutants and mortality or hospital admissions due to PTB. Overall quality of evidence was graded as low (GRADE approach). Exposure to PM2.5, PM10 and SO2 air pollutants was found to be associated with an increased incidence of PTB, while exposure to CO, NO2 and O3 was not. There was no observed association between exposure to these air pollutants and hospital admission or mortality due to PTB. The quality of the evidence generated, however, remains low. Addressing the tuberculosis epidemic by 2030 as per the 4th Sustainable Development Goal may require a more rigorous exploration of this association.

95. Contamination level, sources, and health risk of polycyclic aromatic hydrocarbons in suburban vegetable field soils of Changchun, Northeast China.

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2022 Jul 4

Cui Z, Wang Y, Du L

96. Effects of aging on functional connectivity in a neurodegenerative risk cohort: resting state versus task measurement using near-infrared spectroscopy.

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2022 Jul 4

Blum L(#), Hofmann A(#), Rosenbaum D

97. The iodide transporter Slc26a7 impacts thyroid function more strongly than Slc26a4 in mice.

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2022 Jul 4

Yamaguchi N(#), Suzuki A(#), Yoshida A

98. A brassinosteroid functional analogue increases soybean drought resilience.

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2022 Jul 4

Perez-Borroto LS, Guzzo MC, Posada G

99. The genetic consequences of captive breeding, environmental change and human exploitation in the endangered peninsular pronghorn.

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2022 Jul 4

Klimova A, Gutiérrez-Rivera JN, Sánchez-Sotomayor V

100. Fabrication of near-invisible solar cell with monolayer WS(2).

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2022 Jul 4

He X, Iwamoto Y, Kaneko T

101. Quantitative measure of concrete fragment using ANN to consider uncertainties under impact loading.

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2022 Jul 4

Kim K, Kim W, Seo J

102. Necroptosis-related lncRNA signatures determine prognosis in breast cancer patients.

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2022 Jul 4

Zhang Y, Yue Q, Cao F

103. Study of tribological properties of human buccal epithelium cell membranes using probe microscopy.

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2022 Jul 4

Torhov NA, Mosunov AA, Novikov VA

104. Evaluation of heavy metal contamination in copper mine tailing soils of Kitwe and Mufulira, Zambia, for reclamation prospects.

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2022 Jul 4

Dusengemungu L, Mubemba B, Gwanama C.

105. Laser cluster interaction in ambient magnetic fields for accelerating electrons in two stages without external injection.

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2022 Jul 4

Swain K, Mahalik SS, Kundu M.

In the few-cycle pulse regime of laser-cluster interaction (intensity [Formula: see text], wavelength [Formula: see text] nm), laser absorption is mostly collisionless and may happen via anharmonic resonance (AHR) process in the overdense (cluster) plasma potential. Many experiments, theory and simulation show average absorbed energy per cluster-electron ([Formula: see text]) close to the electron's ponderomotive energy ([Formula: see text]) in the collisionless regime. In this work, by simple rigid sphere model (RSM) and detailed particle-in-cell (PIC) simulation, we show enhanced [Formula: see text] 30-70[Formula: see text]-a 15-30 fold increase-with an external (crossed) magnetic field near the electron-cyclotron resonance (ECR). Due to relativistic mass increase, electrons quickly deviate from the standard (non-relativistic) ECR, but time-dependent relativistic-ECR (RECR) happens which also contributes to enhanced [Formula: see text]. Here laser is coupled to electrons in two stages, i.e, AHR and ECR/RECR. To probe further we retrieve the phase-difference [Formula: see text] between the driving electric field and corresponding velocity component for each electron (in PIC and RSM). We find absorption by electron via AHR happens in a very short interval [Formula: see text] for less than half a laser period where [Formula: see text] remains close to [Formula: see text] (necessary condition for maximum laser absorption) and then [Formula: see text] drops to its initial [Formula: see text] (meaning no absorption) after such short-lived AHR. On the contrary, auxiliary magnetic field near the ECR modifies AHR scenario inside the cluster and also helps maintaining the required phase [Formula: see text] for the liberated cluster-electron accompanied by frequency matching for ECR/RECR for a prolonged [Formula: see text] (which covers 50-60% of the laser pulse through pulse maxima) even after AHR-leading to jump in [Formula: see text] 30-70[Formula: see text]. We note that to realize the second stage of enhanced energy coupling via ECR/RECR, the first stage via AHR is necessary.

106. Motivations underlying self-infliction of pain during thinking for pleasure.

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2022 Jul 4

Eder AB, Maas F, Schubmann A

107. Comprehensive analysis of autophagy related long non-coding RNAs in prognosis, immunity, and treatment of muscular invasive bladder cancer.

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2022 Jul 4

Tan W, Yuan Y, Huang H

108. NAC transcription factors ATAF1 and ANAC055 affect the heat stress response in Arabidopsis.

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2022 Jul 4

Alshareef NO, Otterbach SL, Allu AD

109. Smoking remains associated with education after controlling for social background and genetic factors in a study of 18 twin cohorts.

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2022 Jul 31

Silventoinen K, Piirtola M, Jelenkovic A

110. Theaflavin 3-gallate inhibits the main protease (M(pro)) of SARS-CoV-2 and reduces its count in vitro.

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2022 Jul 30

Chauhan M(#), Bhardwaj VK(#), Kumar A

111. Ym155 localizes to the mitochondria leading to mitochondria dysfunction and activation of AMPK that inhibits BMP signaling in lung cancer cells.

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2022 Jul 30

Mondal A, Jia D, Bhatt V

112. An ANN-based advancing double-front method for automatic isotropic triangle generation.

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2022 Jul 30

Lu P, Wang N, Chang X

113. Increasing vitamin C through agronomic biofortification of arugula microgreens.

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2022 Jul 30

Kathi S, Laza H, Singh S

114. Calorie restriction has no effect on bone marrow tumour burden in a Vk*MYC transplant model of multiple myeloma.

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2022 Jul 30

Bradey AL, Fitter S, Duggan J

115. Learning to rank Higgs boson candidates.

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2022 Jul 30

Köppel M, Segner A, Wagener M

116. Intervention is a better predictor of tDCS mind-wandering effects than subjective beliefs about experimental results.

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2022 Jul 30

Gordon MS, Seeto JXW, Dux PE

117. Exome sequencing revealed comparable frequencies of RNF43 and BRAF mutations in Middle Eastern colorectal cancer.

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2022 Jul 30

Siraj AK(#), Bu R(#), Masoodi T(#)

118. Foveal eversion patterns in diabetic macular edema.

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2022 Jul 30

Arrigo A, Saladino A, Aragona E

119. Global slowness and increased intra-individual variability are key features of attentional deficits and cognitive fluctuations in post COVID-19 patients.

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2022 Jul 30

Ortelli P(#), Benso F(#), Ferrazzoli D

Fatigue, attentional deficits and cognitive fluctuations are the most characterizing symptoms of neurological involvement in Post COVID-19 syndrome (PCS). As the intraindividual variability (IIV) in cognitive performances has been recognized as a hallmark of brain-related disorders associated with cognitive deficits, it could be an interesting measure to elucidate the mechanisms subtending both the attentive impairment and the cognitive fluctuations in these patients. By referring to IIV analysis of Reaction Times (RTs), the present study aims to define the attentive impairment and its relation to fluctuations and fatigue, in patients suffering from Post COVID-19 neurological symptoms. 74 patients were enrolled. They underwent an extensive clinical and neuropsychological assessments, as well as computerized Sustained Attention and Stroop tasks. For studying IIV, RTs distributions of performances in computerized tasks were fitted with ex-Gaussian distribution, for obtaining the τ values. Finally, the Resting Motor Threshold (RMT) was also collected to estimate cortical excitability. 29 healthy volunteers served as controls. Patients showed poorer scores in Montreal Cognitive Assessment and higher RMT, in comparison with controls. In Sustained Attention Task, Mean, µ, σ and τ values were significantly higher in PCS patients (p value = < 0.0001; 0.001; 0.018 and < 0.0001, respectively). Repeated measures ANOVA comparing the RTs mean in Stroop task within-subject and between-subjects revealed significant condition and group effect (p < 0.0001 both) and significant interaction (p = 0.005), indicating worst performances in patients. The mean of the derived interference value was significantly higher in PCS patients than in controls (p = 0.036). Patients suffering from PCS show deficits in attention, both in the sustained and executive components. Both high RTs means and high IIV subtend these deficits and could explain the often-complained cognitive fluctuations in this population.

120. LITOS: a versatile LED illumination tool for optogenetic stimulation.

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2022 Jul 30

Höhener TC(#), Landolt AE(#), Dessauges C

121. Fabrication of polyamide-12/cement nanocomposite and its testing for different dyes removal from aqueous solution: characterization, adsorption, and regeneration studies.

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2022 Jul 30

Aldahash SA, Higgins P, Siddiqui S

122. Modulation of dielectric properties in low-loss polypropylene-based composites at GHz frequencies: theory and experiment.

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2022 Jul 30

Wilczyński K, Wróblewska A, Daniszewska A

123. Enhancement of fatigue resistance by recrystallization and grain growth to eliminate bonding interfaces in Cu-Cu joints.

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2022 Jul 30

Ong JJ, Tran DP, Lan MC

124. Stochastic consolidation of lifelong memory.

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2022 Jul 30

Shaham N, Chandra J, Kreiman G

125. Molecular occurrence and risk factors for Toxoplasma gondii infection in equids in Jilin, China.

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2022 Jul 30

Liang W(#), Zhao S(#), Wang N(#)

126. Paradoxical effects of altruism on efforts to mitigate climate change.

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2022 Jul 29

Fossas-Tenas A, Ibelings BW, Kasparian J

127. Evaluation of the microbial reduction efficacy and perception of use of an ozonized water spray disinfection technology.

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2022 Jul 29

Mascarenhas LAB, Dos Santos LMC, Oliveira FO

128. Brain potential responses involved in decision-making in weightlessness.

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2022 Jul 29

Cebolla AM, Petieau M, Palmero-Soler E

129. Locating critical events in AFM force measurements by means of one-dimensional convolutional neural networks.

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2022 Jul 29

Sotres J, Boyd H, Gonzalez-Martinez JF.

130. Genomic analysis of a novel Neanderthal from Mezmaiskaya Cave provides insights into the genetic relationships of Middle Palaeolithic populations.

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2022 Jul 29

Andreeva TV, Manakhov AD, Gusev FE

131. The abundance of bifidobacterium in relation to visceral obesity and serum uric acid.

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2022 Jul 29

Gong H, Gao H, Ren Q

132. Organic amendment additions to cadmium-contaminated soils for phytostabilization of three bioenergy crops.

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2022 Jul 29

Taeprayoon P, Homyog K, Meeinkuirt W.

133. Surgical and functional outcomes of robot-assisted versus laparoscopic partial nephrectomy with cortical renorrhaphy omission.

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2022 Jul 29

Kubota M, Yamasaki T, Murata S

134. Deep learning-based defects detection of certain aero-engine blades and vanes with DDSC-YOLOv5s.

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2022 Jul 29

Li X, Wang W, Sun L

135. Long-term clinical outcomes and predictive factors in patients with chronic ocular graft-versus-host disease.

Sci Rep

2022 Jul 29

Yoon HJ, Song GY, Yoon KC.

136. Differential association between the GLP1R gene variants and brain functional connectivity according to the severity of alcohol use.

Sci Rep

2022 Jul 29

Farokhnia M(#), Fede SJ(#), Grodin EN

Growing evidence suggests that the glucagon-like peptide-1 (GLP-1) system is involved in mechanisms underlying alcohol seeking and consumption. Accordingly, the GLP-1 receptor (GLP-1R) has begun to be studied as a potential pharmacotherapeutic target for alcohol use disorder (AUD). The aim of this study was to investigate the association between genetic variation at the GLP-1R and brain functional connectivity, according to the severity of alcohol use. Participants were 181 individuals categorized as high-risk (n = 96) and low-risk (n = 85) alcohol use, according to their AUD identification test (AUDIT) score. Two uncommon single nucleotide polymorphisms (SNPs), rs6923761 and rs1042044, were selected a priori for this study because they encode amino-acid substitutions with putative functional consequences on GLP-1R activity. Genotype groups were based on the presence of the variant allele for each of the two GLP-1R SNPs of interest [rs6923761: AA + AG (n = 65), GG (n = 116); rs1042044: AA + AC (n = 114), CC (n = 67)]. Resting-state functional MRI data were acquired for 10 min and independent component (IC) analysis was conducted. Multivariate analyses of covariance (MANCOVA) examined the interaction between GLP-1R genotype group and AUDIT group on within- and between-network connectivity. For rs6923761, three ICs showed significant genotype × AUDIT interaction effects on within-network connectivity: two were mapped onto the anterior salience network and one was mapped onto the visuospatial network. For rs1042044, four ICs showed significant interaction effects on within-network connectivity: three were mapped onto the dorsal default mode network and one was mapped onto the basal ganglia network. For both SNPs, post-hoc analyses showed that in the group carrying the variant allele, high versus low AUDIT was associated with stronger within-network connectivity. No significant effects on between-network connectivity were found. In conclusion, genetic variation at the GLP-1R was differentially associated with brain functional connectivity in individuals with low versus high severity of alcohol use. Significant findings in the salience and default mode networks are particularly relevant, given their role in the neurobiology of AUD and addictive behaviors.

137. Spatiotemporal changes in influenza A virus prevalence among wild waterfowl inhabiting the continental United States throughout the annual cycle.

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2022 Jul 29

Kent CM, Ramey AM, Ackerman JT

138. Balsam fir (Abies balsamea) needles and their essential oil kill overwintering ticks (Ixodes scapularis) at cold temperatures.

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2022 Jul 29

Adamo SA, El Nabbout A, Ferguson LV

139. N(1)-methyl-pseudouridine is incorporated with higher fidelity than pseudouridine in synthetic RNAs.

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2022 Jul 29

Chen TH, Potapov V, Dai N

140. Long-term changes in serum silver concentrations after extremity reconstruction with silver-coated megaprostheses.

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2022 Jul 29

Smolle MA, Bergovec M, Scheipl S

Silver-coated megaprostheses are considered to reduce infection rate following reconstruction of bone defects in tumour surgery or revision arthroplasty. However, little is known about systemic silver exposure and possible side effects. The aim of this study was to analyse serum silver concentrations in patients with silver-coated megaprostheses over a prolonged time period. Between 2004 and 2016, 46 patients (52.2% female, mean age at surgery 47.1 ± 24.2 years) received silver-coated megaprostheses for septic (n = 26) or oncological (n = 17; main implant since 2013) indications, or aseptic loosening (n = 3). Blood was drawn from all patients within the first few days following surgery (without silver ion levels) and thereafter every 6 months at the outpatient department (with silver ion levels). Inductively coupled plasma mass spectrometry was used to determine silver ion levels. Median follow-up was 47.3 months (IQR: 16.1-78.9). Overall, 29 revision surgeries became necessary in 20 patients, equivalent to a cumulative complication rate of 63.0%. Revisions were most commonly for periprosthetic joint infections (PJIs, n = 12) and instability/soft tissue problems (n = 10). Revision-free implant survival was 81.4%, 42.3% and 35.2% at one, 5 and 10 years. Incidence of local argyria was 8.7% (n = 4). Silver ion levels at two or more consecutive time points during follow-up were available for 26 patients. An increment of silver levels within the first months ("run-in") was observed, followed by an unspecific undulating course. Median initial and latest follow-up (median, 49.5 months) serum silver ion levels were 16.0 ppb (IQR: 9.1-29.1) and 7.4 ppb (IQR: 2.7-14.1), respectively. According to the multivariate mixed linear random-effects model, development of PJI was associated with significantly higher silver ion levels over time (p = 0.002), irrespective of time from surgery (p = 0.274). In the current series, a cumulative complication rate of 63.0% was observed for patients receiving silver-coated megaprostheses for septic of oncological indications. An overall unspecific course of silver ion concentration was present. Development of PJI was significantly associated with increased silver ion levels over time. Yet, no systemic complication associated to high silver levels occurred. It can be concluded that silver-coated implants constitute a safe solution for megaprosthetic reconstruction, but monitoring of silver concentrations is recommended.

141. Metformin treatment is associated with improved outcome in patients with diabetes and advanced heart failure (HFrEF).

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2022 Jul 29

Benes J, Kotrc M, Kroupova K

142. The adverse impact of herbicide Roundup Ultra Plus in human spermatozoa plasma membrane is caused by its surfactant.

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2022 Jul 29

Torres-Badia M, Solar-Malaga S, Serrano R

143. Miscibility of rock and ice in the interiors of water worlds.

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2022 Jul 29

Kovačević T, González-Cataldo F, Stewart ST

144. Thermoresponsive C22 phage stiffness modulates the phage infectivity.

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2022 Jul 29

Sae-Ueng U, Bhunchoth A, Phironrit N

145. Metagenomic analysis reveals associations between salivary microbiota and body composition in early childhood.

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2022 Jul 29

Coker MO(#), Lebeaux RM(#), Hoen AG

146. Study on emergency escape route planning under fire accidents in the Burtai coal mine.

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2022 Jul 29

Jinzhang J, Fengxiao W.

147. Intrapulpal temperature changes during the cementation of ceramic veneers.

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2022 Jul 28

Lempel E, Kincses D, Szebeni D

148. Stability indicating potentiometric method for the determination of palonosetron HCl using two different sensors.

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2022 Jul 28

Tantawy MA, Elshabasy DA, Youssef NF

149. The CCR5 antagonist maraviroc exerts limited neuroprotection without improving neurofunctional outcome in experimental pneumococcal meningitis.

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2022 Jul 28

Le ND(#), Steinfort M(#), Grandgirard D

150. The green tea catechin EGCG provides proof-of-concept for a pan-coronavirus attachment inhibitor.

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2022 Jul 28

LeBlanc EV, Colpitts CC.

151. Connexin43 represents an important regulator for Sertoli cell morphology, Sertoli cell nuclear ultrastructure, and Sertoli cell maturation.

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2022 Jul 28

Staggenborg S, Koch R, Rode K

152. Synthesis of innovative triphenylamine-functionalized organic photosensitizers outperformed the benchmark dye N719 for high-efficiency dye-sensitized solar cells.

Sci Rep

2022 Jul 28

Badawy SA, Abdel-Latif E, Fadda AA

Herein, we present a thorough photovoltaic investigation of four triphenylamine organic sensitizers with D-π-A configurations and compare their photovoltaic performances to the conventional ruthenium-based sensitizer N719. SFA-5-8 are synthesized and utilized as sensitizers for dye-sensitized solar cell (DSSC) applications. The effects of the donor unit (triphenylamine), π-conjugation bridge (thiophene ring), and various acceptors (phenylacetonitrile and 2-cyanoacetamide derivatives) were investigated. Moreover, this was asserted by profound calculations of HOMO (highest occupied molecular orbital) and LUMO (lowest unoccupied molecular orbital) energy levels, the molecular electrostatic potential (MEP), and natural bond orbital (NBO) that had been studied for the TPA-sensitizers. Theoretical density functional theory (DFT) was performed to study the distribution of electron density between donor and acceptor moieties. The sensitization by the absorption of sensitizers SFA-5-8 leads to an obvious enhancement in the visible light absorption (300-750 nm) as well as a higher photovoltaic efficiency in the range of (5.53-7.56%). Under optimized conditions, SFA-7 showed outstanding sensitization of nanocrystalline TiO2, resulting in enhancing the visible light absorption and upgrading the power conversion efficiency (PCE) to approximately 7.56% over that reported for the N719 (7.29%). Remarkably, SFA-7 outperformed N719 by 4% in the total conversion efficiency. Significantly, the superior performance of SFA-7 could be mainly ascribed to the higher short-circuit photocurrents (Jsc) in parallel with larger open-circuit voltages (Voc) and more importantly, the presence of different anchoring moieties that could enhance the ability to fill the gaps on the surface of the TiO2 semiconductor. That could be largely reflected in the overall enhancement in the device efficiency. Moreover, the theoretical electronic and photovoltaic properties of all studied sensitizers have been compared with experimental results. All the 2-cyanoacrylamide derivative sensitizers demonstrated robust photovoltaic performance.

153. Identifying potential mechanisms between childhood trauma and the psychological response to the COVID-19 pandemic in Germany: a longitudinal study.

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2022 Jul 28

Rek SV, Reinhard MA, Bühner M

154. Microbial dysbiosis and fecal metabolomic perturbations in Yorkshire Terriers with chronic enteropathy.

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2022 Jul 28

Galler AI, Suchodolski JS, Steiner JM

155. Assessment of diagnostic utility of serum hemeoxygenase-1 measurement for acute exacerbation of interstitial pneumonias.

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2022 Jul 28

Kata Y, Hara Y, Tagami Y

156. Using the articularis genu to test peri-articular muscle health during knee osteoarthritis.

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2022 Jul 28

Cruz Ayala JA, Crawford M, Gatterer MC

157. Water activated disposable paper battery.

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2022 Jul 28

Poulin A, Aeby X, Nyström G.

158. New prediction method of horizontal principal stress of deep tight reservoirs.

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2022 Jul 28

Fang X, Zhang J, Liu T

159. Assessing temporal correlation in environmental risk factors to design efficient area-specific COVID-19 regulations: Delhi based case study.

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2022 Jul 28

Chaudhary V, Bhadola P, Kaushik A

160. Effects of elevated serum urate on cardiometabolic and kidney function markers in a randomised clinical trial of inosine supplementation.

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2022 Jul 28

Dalbeth N, Mihov B, Stewart A

161. A digital alkali spin maser.

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2022 Jul 28

Ingleby S, Griffin P, Dyer T

162. Clinical and neurophysiological effects of central thalamic deep brain stimulation in the minimally conscious state after severe brain injury.

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2022 Jul 28

Arnts H, Tewarie P, van Erp WS

163. Psychosocial work environment as a dynamic network: a multi-wave cohort study.

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2022 Jul 28

Elovainio M, Hakulinen C, Komulainen K

164. Clinical significance of germline telomere length and associated genetic factors in patients with neuroblastoma.

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2022 Jul 28

Bae JS(#), Lee JW(#), Joung JG

Studies investigating the relationship between germline telomere length and the clinical characteristics of tumors are very limited. This study evaluated the relationship between germline telomere length and the clinical characteristics of neuroblastoma. In addition, a genome-wide association study (GWAS) was performed to investigate the genetic factors associated with germline telomere length. The germline telomere length of peripheral blood mononuclear cells from 186 patients with neuroblastoma was measured by quantitative polymerase chain reaction. The association between germline telomere length and clinical characteristics, including long-term survival, was investigated. For the GWAS, genotyping was performed with a high-density bead chip (Illumina, San Diego, CA, USA). After strict quality-control checks of the samples, an association analysis was conducted. The result showed that longer germline telomeres were significantly associated with longer event-free survival (P = 0.032). To identify significantly assocated genetic markers for germline telomere length, genome wide association analysis was performed. As a result, several single nucleotide polymorphisms located in HIVEP3, LRRTM4, ADGRV1, RAB30, and CHRNA4 genes were discovered. During gene-based analysis (VEGAS2 tool), the CNTN4 gene had the most significant association with germline telomere length (P = 1.0E-06). During gene ontology analysis, susceptible genes associated with germline telomere length were mainly distributed in neurite morphogenesis and neuron development. A longer germline telomere length is associated with favorable prognostic factors at diagnosis and eventually better event-free survival in patients with neuroblastoma. In addition, the GWAS demonstrated that genetic markers and genes related to germline telomere length are associated with neurite morphogenesis and neuron development. Further research with larger cohorts of patients and functional investigations are needed.

165. Systematic screening and validation of reliable reference genes for qRT-PCR analysis in Okra (Abelmoschus esculentus L.).

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2022 Jul 28

Zhang JR(#), Feng YY(#), Yang MJ

166. The psychophysiological mechanisms of real-world time experience.

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2022 Jul 28

Ogden RS, Dobbins C, Slade K

167. Isolated effects of patellar resurfacing in total knee arthroplasty and their relation to native patellar geometry.

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2022 Jul 28

Sauer A, Thorwaechter C, Dupraz I

168. Social determinants and lifestyle factors for brain health: implications for risk reduction of cognitive decline and dementia.

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2022 Jul 28

Röhr S, Pabst A, Baber R

169. Quasi-dark resonances with antiferromagnetic order in silicon metasurfaces.

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2022 Jul 28

Zografopoulos DC, Algorri JF, López-Higuera JM

170. Inverse design of compact power divider with arbitrary outputs for 5G applications.

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2022 Jul 27

Shadi M(#), Tavakol MR(#), Atlasbaf Z.

171. A nationwide study of patients operated for cervical degenerative disorders in public and private hospitals.

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2022 Jul 27

Danielsen E, Mjåset C, Ingebrigtsen T

During the last decades, there has been an increase in the rate of surgery for degenerative disorders of the cervical spine and in the use of supplementary private health insurance. Still, there is limited knowledge about the differences in characteristics of patients operated in public and private hospitals. Therefore, we aimed at comparing sociodemographic-, clinical- and patient management data on patients operated for degenerative cervical radiculopathy and degenerative cervical myelopathy in public and private hospitals in Norway. This was a cross-sectional study on patients in the Norwegian Registry for Spine Surgery operated for degenerative cervical radiculopathy and degenerative cervical myelopathy between January 2012 and December 2020. At admission for surgery, we assessed disability by the following patient reported outcome measures (PROMs): neck disability index (NDI), EuroQol-5D (EQ-5D) and numerical rating scales for neck pain (NRS-NP) and arm pain (NRS-AP). Among 9161 patients, 7344 (80.2%) procedures were performed in public hospitals and 1817 (19.8%) in private hospitals. Mean age was 52.1 years in public hospitals and 49.7 years in private hospitals (P < 0.001). More women were operated in public hospitals (47.9%) than in private hospitals (31.6%) (P < 0.001). A larger proportion of patients in private hospitals had high education (≥ 4 years of college or university) (42.9% vs 35.6%, P < 0.001). Patients in public hospitals had worse disease-specific health problems than those in private hospitals: unadjusted NDI mean difference was 5.2 (95% CI 4.4 - 6.0; P < 0.001) and adjusted NDI mean difference was 3.4 (95% CI 2.5 - 4.2; P < 0.001), and they also had longer duration of symptoms (P < 0.001). Duration of surgery (mean difference 29 minutes, 95% CI 27.1 - 30.7; P < 0.001) and length of hospital stay (mean difference 2 days, 95% CI 2.3 - 2.4; P < 0.001) were longer in public hospitals. In conclusion, patients operated for degenerative cervical spine in private hospitals were healthier, younger, better educated and more often men. They also had less and shorter duration of symptoms and seemed to be managed more efficiently. Our findings indicate that access to cervical spine surgery in private hospitals could be skewed in favour of patients with higher socioeconomic status.

172. Eicosapentaenoic acid (EPA)-induced inhibitory effects on porcine coronary and cerebral arteries involve inhibition of prostanoid TP receptors.

Sci Rep

2022 Jul 27

Yoshioka K(#), Obara K(#), Oikawa S

173. A multicenter study to compare the effectiveness of the inpatient post acute care program versus traditional rehabilitation for stroke survivors.

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2022 Jul 27

Chang KV, Chen KH, Chen YH

174. A comparative study of a rabbit spinal tuberculosis model constructed by local direct infection via the posterior lateral approach.

Sci Rep

2022 Jul 27

Yue X(#), Zhu X(#), Wu L

The present study aims to establish a method of constructing a New Zealand rabbit spinal tuberculosis model by direct local infusion of M. tuberculosis H37Rv strain into the intervertebral disc space through the posterior lateral approach. Sixty-six New Zealand rabbits were pretreated with complete Freund's adjuvant and randomly divided into 4 group: the posterolateral approach model group (Group A, 25), ventral transverse process approach model group (Group B, 25), control group (Group C, 10), and blank group (Group D, 6). In Groups A and B, the bone holes were filled with gelatin sponge after drilling, and the local area was directly infused with 0.1 ml of M. tuberculosis H37Rv strain suspension. In Group C, the gelatin sponge was filled through the posterolateral approach and the local area was infused with 0.1 ml of normal saline suspension. In Group D, No specific treatment was performed. The general conditions of the experimental rabbits in each group were compared to those of a control group; the degree of vertebral body exposure, incision length, and complications of the two methods were compared; and the tuberculosis models were evaluated by imaging, histopathology, and bacterial culture. In Group A, the lateral side of the vertebral body was well exposed, the damage was mild, and no peritoneal rupture or gastrointestinal complications were observed. In Group B, the ventral side of the vertebral body and the intervertebral disc were exposed, and abdominal complications were more likely to occur. The survival rates of the experimental rabbits at 8 weeks after surgery were 92.0% in Group A, 88.00% in Group B, 90.0% in Group C, and 100% in Group D. MRI examinations showed that in Group A, the positive rate of radiographic bone findings was 86.9% at 4 weeks after surgery and 100% at 8 weeks after surgery; in Group B, the positive rate of radiographic bone findings was 78.2% at 4 weeks after surgery and 95.4% at 8 weeks after surgery. There was no significant difference between Groups A and B in the radiographic bone findings rate detected by the same imaging method at the same time point (P > 0.05). Eight weeks after surgery, bone destruction, paravertebral abscess, and caseous necrosis occurred in the vertebral bodies of surviving rabbits in Groups A and B. The BacT/ALERT 3D rapid culture system was used to culture the pus in the lesion, and the results showed that the positive rate of tuberculosis was 52.17% in Group A and 54.54% in Group B, and the difference was not statistically significant (P > 0.05). After pretreatment with complete Freund's adjuvant, direct infusion of the H37Rv strain of M. tuberculosis into the intervertebral disc space of New Zealand rabbits via the posterolateral approach and the ventral transverse process approach can successfully establish rabbit spinal tuberculosis models.

175. Spatial distribution differences of 25-hydroxyvitamin D in healthy elderly people under the influence of geographical environmental factors.

Sci Rep

2022 Jul 27

Yang W, Ge M, Wang Y

176. Contamination analysis of Arctic ice samples as planetary field analogs and implications for future life-detection missions to Europa and Enceladus.

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2022 Jul 27

Coelho LF, Blais MA, Matveev A

177. Progressive crushing (40)Ar/(39)Ar dating of a gold-bearing quartz vein from the Liaotun Carlin-type gold deposit, Guangxi, southern China.

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2022 Jul 27

Hu R, Pang B, Bai X

178. Assessing agreement between different polygenic risk scores in the UK Biobank.

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2022 Jul 27

Clifton L, Collister JA, Liu X

179. Home-cage behavior in the Stargazer mutant mouse.

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2022 Jul 27

Schirmer C, Abboud MA, Lee SC

180. Series arc fault detection based on continuous wavelet transform and DRSN-CW with limited source data.

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2022 Jul 27

Hu C, Qu N, Zhang S.

181. Optimization of the 4-anilinoquin(az)oline scaffold as epidermal growth factor receptor (EGFR) inhibitors for chordoma utilizing a toxicology profiling assay platform.

Sci Rep

2022 Jul 27

Bieberich AA, Laitinen T, Maffuid K

182. Identifying pathways to increased volunteering in older US adults.

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2022 Jul 27

Nakamura JS, Lee MT, Chen FS

183. Cytokine changes in cerebrospinal fluid following vascular surgery on the thoracic aorta.

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2022 Jul 27

Pereira C, Perera AH, Rudarakanchana N

184. The relationship between serum sex hormone and cardiac echocardiographic findings in healthy men.

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2022 Jul 27

Yeo Y, Park SW, Lee SC(#)

185. Effects of polyethylene oxide particles on the photo-physical properties and stability of FA-rich perovskite solar cells.

Sci Rep

2022 Jul 27

Koech RK, Olanrewaju YA, Ichwani R

186. Best practices for instrumenting honey bees.

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2022 Jul 27

Koenig PA, Petersen KH.

187. Stable isotopes unveil one millennium of domestic cat paleoecology in Europe.

Sci Rep

2022 Jul 27

Krajcarz M(#), Van Neer W(#), Krajcarz MT(#)

188. Construction of a new automatic grading system for jaw bone mineral density level based on deep learning using cone beam computed tomography.

Sci Rep

2022 Jul 27

Xiao Y(#), Liang Q(#), Zhou L

189. Gene Updater: a web tool that autocorrects and updates for Excel misidentified gene names.

Sci Rep

2022 Jul 26

Koh CWT(#), Ooi JSG(#), Joly GLC

190. Persistent popliteal lymphatic muscle cell coverage defects despite amelioration of arthritis and recovery of popliteal lymphatic vessel function in TNF-Tg mice following anti-TNF therapy.

Sci Rep

2022 Jul 26

Kenney HM, Peng Y, Bell RD

While rheumatoid arthritis patients and tumor necrosis factor transgenic (TNF-Tg) mice with inflammatory-erosive arthritis display lymphatic drainage deficits, the mechanisms responsible remain unknown. As ultrastructural studies of joint-draining popliteal lymphatic vessels (PLVs) in TNF-Tg mice revealed evidence of lymphatic muscle cell (LMC) damage, we aimed to evaluate PLV-LMC coverage in TNF-Tg mice. We tested the hypothesis that alpha smooth muscle actin (αSMA)+ PLV-LMC coverage decreases with severe inflammatory-erosive arthritis, and is recovered by anti-TNF therapy facilitated by increased PLV-LMC turnover during amelioration of joint disease. TNF-Tg mice with established disease received anti-TNF monoclonal antibody (mAb) or placebo IgG isotype control mAb therapy (n = 5) for 6-weeks, while wild-type (WT) littermates (n = 8) received vehicle (PBS). Bromodeoxyuridine (BrdU) was also administered daily during the treatment period to monitor PLV-LMC turnover. Effective anti-TNF therapy was confirmed by longitudinal assessment of popliteal lymph node (PLN) volume via ultrasound, PLV contraction frequency via near-infrared imaging of indocyanine green, and ankle bone volumes via micro-computed tomography (micro-CT). Terminal knee micro-CT, and ankle and knee histology were also performed. PLVs were immunostained for αSMA and BrdU to evaluate PLV-LMC coverage and turnover, respectively, via whole-mount fluorescent microscopy. Anti-TNF therapy reduced PLN volume, increased talus and patella bone volumes, and reduced tarsal and knee synovial areas compared to placebo treated TNF-Tg mice (p < 0.05), as expected. Anti-TNF therapy also increased PLV contraction frequency at 3-weeks (from 0.81 ± 1.0 to 3.2 ± 2.0 contractions per minute, p < 0.05). However, both anti-TNF and placebo treated TNF-Tg mice exhibited significantly reduced αSMA+ PLV-LMC coverage compared to WT (p < 0.05). There was no correlation of αSMA+ PLV-LMC coverage restoration with amelioration of inflammatory-erosive arthritis. Similarly, there was no difference in PLV-LMC turnover measured by BrdU labeling between WT, TNF-Tg placebo, and TNF-Tg anti-TNF groups with an average of < 1% BrdU+ PLV-LMCs incorporated per week. Taken together these results demonstrate that PLV-LMC turnover in adult mice is limited, and that recovery of PLV function during amelioration of inflammatory-erosive arthritis occurs without restoration of αSMA+ LMC coverage. Future studies are warranted to investigate the direct and indirect effects of chronic TNF exposure, and the role of proximal inflammatory cells on PLV contractility.

191. Deep learning to distinguish Best vitelliform macular dystrophy (BVMD) from adult-onset vitelliform macular degeneration (AVMD).

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2022 Jul 26

Crincoli E, Zhao Z, Querques G

192. Mathematical analysis of hybrid mediated blood flow in stenosis narrow arteries.

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2022 Jul 26

Hussain A, Sarwar L, Rehman A

193. Forms of application of silicon in quinoa and benefits involved in the association between productivity with grain biofortification.

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2022 Jul 26

Lata-Tenesaca LF, de Mello Prado R, de Cássia Piccolo M

194. Reference gene selection in bovine caruncular epithelial cells under pregnancy-associated hormones exposure.

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2022 Jul 26

Sozoniuk M, Jamioł M, Kankofer M

195. High-performance Mach-Zehnder modulator using tailored plasma dispersion effects in an ITO/graphene-based waveguide.

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2022 Jul 26

Mohammadi-Pouyan S, Bahadori-Haghighi S, Heidari M

196. Substantial impact of 3-iodothyronamine (T1AM) on the regulations of fluorescent thermoprobe-measured cellular temperature and natriuretic peptide expression in cardiomyocytes.

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2022 Jul 26

Takahashi H, Nagoshi T, Kimura H

197. Structural diagnosis of benthic invertebrate communities in relation to salinity gradient in Baltic coastal lake ecosystems using biological trait analysis.

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2022 Jul 26

Matela M, Obolewski K.

198. Ultrasound-based radiomics technology in fetal lung texture analysis prediction of neonatal respiratory morbidity.

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2022 Jul 26

Du Y(#), Jiao J(#), Ji C

199. Spatio-temporal photolysis rate profiles of UV(254) irradiated toluene.

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2022 Jul 26

El-Tawargy AS.

200. A multifaceted strategy to improve recombinant expression and structural characterisation of a Trypanosoma invariant surface protein.

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2022 Jul 26

Sülzen H, Votrubova J, Dhillon A

201. The method of lines extension for the analysis of multilayered graphene-loaded structures in cylindrical coordinates.

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2022 Jul 26

Mehrdadian A, Forooraghi K, Bideskan MZ.

202. Left ventricular active strain energy density is a promising new measure of systolic function.

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2022 Jul 26

MacIver DH, Agger P, Rodrigues JCL

The left ventricular ejection fraction does not accurately predict exercise capacity or symptom severity and has a limited role in predicting prognosis in heart failure. A better method of assessing ventricular performance is needed to aid understanding of the pathophysiological mechanisms and guide management in conditions such as heart failure. In this study, we propose two novel measures to quantify myocardial performance, the global longitudinal active strain energy (GLASE) and its density (GLASED) and compare them to existing measures in normal and diseased left ventricles. GLASED calculates the work done per unit volume of muscle (energy density) by combining information from myocardial strain and wall stress (contractile force per unit cross sectional area). Magnetic resonance images were obtained from 183 individuals forming four cohorts (normal, hypertension, dilated cardiomyopathy, and cardiac amyloidosis). GLASE and GLASED were compared with the standard ejection fraction, the corrected ejection fraction, myocardial strains, stroke work and myocardial forces. Myocardial shortening was decreased in all disease cohorts. Longitudinal stress was normal in hypertension, increased in dilated cardiomyopathy and severely decreased in amyloid heart disease. GLASE was increased in hypertension. GLASED was mildly reduced in hypertension (1.39 ± 0.65 kJ/m3), moderately reduced in dilated cardiomyopathy (0.86 ± 0.45 kJ/m3) and severely reduced in amyloid heart disease (0.42 ± 0.28 kJ/m3) compared to the control cohort (1.94 ± 0.49 kJ/m3). GLASED progressively decreased in the hypertension, dilated cardiomyopathy and cardiac amyloid cohorts indicating that mechanical work done and systolic performance is severely reduced in cardiac amyloid despite the relatively preserved ejection fraction. GLASED provides a new technique for assessing left ventricular myocardial health and contractile function.

203. Structural, electrical, and magnetic properties of nano Sr(1-X)La(X)Fe(12)O(19) (X = 0.2-0.8).

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2022 Jul 26

Baba Basha D, Suresh Kumar N, Chandra Babu Naidu K

204. Structural design and performance study of primitive triply periodic minimal surfaces Ti6Al4V biomimetic scaffold.

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2022 Jul 26

Qin Y, Wang Q, Shi C

205. Risk for Behçet's disease gauged via high-density lipoprotein cholesterol: a nationwide population-based study in Korea.

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2022 Jul 26

Kim YH, Kim HJ, Park JW

206. Invasive brown treesnakes (Boiga irregularis) move short distances and have small activity areas in a high prey environment.

Sci Rep

2022 Jul 26

Boback SM, Nafus MG, Yackel Adams AA

207. AutoComBat: a generic method for harmonizing MRI-based radiomic features.

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2022 Jul 26

Carré A, Battistella E, Niyoteka S

The use of multicentric data is becoming essential for developing generalizable radiomic signatures. In particular, Magnetic Resonance Imaging (MRI) data used in brain oncology are often heterogeneous in terms of scanners and acquisitions, which significantly impact quantitative radiomic features. Various methods have been proposed to decrease dependency, including methods acting directly on MR images, i.e., based on the application of several preprocessing steps before feature extraction or the ComBat method, which harmonizes radiomic features themselves. The ComBat method used for radiomics may be misleading and presents some limitations, such as the need to know the labels associated with the "batch effect". In addition, a statistically representative sample is required and the applicability of a signature whose batch label is not present in the train set is not possible. This work aimed to compare a priori and a posteriori radiomic harmonization methods and propose a code adaptation to be machine learning compatible. Furthermore, we have developed AutoComBat, which aims to automatically determine the batch labels, using either MRI metadata or quality metrics as inputs of the proposed constrained clustering. A heterogeneous dataset consisting of high and low-grade gliomas coming from eight different centers was considered. The different methods were compared based on their ability to decrease relative standard deviation of radiomic features extracted from white matter and on their performance on a classification task using different machine learning models. ComBat and AutoComBat using image-derived quality metrics as inputs for batch assignment and preprocessing methods presented promising results on white matter harmonization, but with no clear consensus for all MR images. Preprocessing showed the best results on the T1w-gd images for the grading task. For T2w-flair, AutoComBat, using either metadata plus quality metrics or metadata alone as inputs, performs better than the conventional ComBat, highlighting its potential for data harmonization. Our results are MRI weighting, feature class and task dependent and require further investigations on other datasets.

208. Synthesis of Candida Antarctica Lipase B (CALB) enzyme-powered magnetite nanomotor based on PCL/Chitosan Janus nanostructure.

Sci Rep

2022 Jul 26

Mafakheri F, Khoee S.

209. Cellular analysis of SOD1 protein-aggregation propensity and toxicity: a case of ALS with slow progression harboring homozygous SOD1-D92G mutation.

Sci Rep

2022 Jul 25

Sawamura M, Imamura K, Hikawa R

210. Cholesterol affects the relationship between albumin and major adverse cardiac events in patients with coronary artery disease: a secondary analysis.

Sci Rep

2022 Jul 25

Yao YF(#), Chen ZY(#), Luo TY

211. 2450-MHz microwave ablation of liver metastases under 3.0 T wide-bore magnetic resonance guidance: a pilot study.

Sci Rep

2022 Jul 25

Xu K, Li Z, Liu Y

212. Association of circulating gene expression signatures with stiffness following total knee arthroplasty for osteoarthritis: a pilot study.

Sci Rep

2022 Jul 25

Kirksey MA, Lessard SG(#), Khan M(#)

213. Lymphoma total lesion glycolysis leads to hyperlactatemia and reduction of brain glucose utilization.

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2022 Jul 25

Yi HK, Yoo J, Kim SJ

214. Comparison between two- and three-dimensional methods for offset measurements after total hip arthroplasty.

Sci Rep

2022 Jul 25

Tone S, Hasegawa M, Naito Y

215. Finite element and in vitro study on biomechanical behavior of endodontically treated premolars restored with direct or indirect composite restorations.

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2022 Jul 25

Maravić T, Comba A, Mazzitelli C

216. Ascent of the conus medullaris in human foetuses: a systematic review and meta-analysis.

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2022 Jul 25

Costa Almeida L, de Souza Figueiredo YJ, Pinheiro Zylberman A

217. The clinical significance of BRAFV600E mutations in pediatric papillary thyroid carcinomas.

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2022 Jul 25

Li Y(#), Wang Y(#), Li L

218. Altered genome-wide hippocampal gene expression profiles following early life lead exposure and their potential for reversal by environmental enrichment.

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2022 Jul 25

Singh G, Singh V, Kim T

219. Polarimetric biomarkers of peri-tumoral stroma can correlate with 5-year survival in patients with left-sided colorectal cancer.

Sci Rep

2022 Jul 25

Lad J, Serra S, Quereshy F

220. A prediction-focused approach to personality modeling.

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2022 Jul 25

Lavi G, Rosenblatt J, Gilead M.

221. Temperature-dependent optical properties of some mixtures nematic liquid crystal.

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2022 Jul 25

Alipanah Z, Zakerhamidi MS, Ranjkesh A.

222. Empagliflozin mitigates endothelial inflammation and attenuates endoplasmic reticulum stress signaling caused by sustained glycocalyx disruption.

Sci Rep

2022 Jul 25

Campeau MA, Leask RL.

223. Population-based screening for celiac disease reveals that the majority of patients are undiagnosed and improve on a gluten-free diet.

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2022 Jul 25

Kvamme JM, Sørbye S, Florholmen J

224. Comparative analysis of temperature preference behavior and effects of temperature on daily behavior in 11 Drosophila species.

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2022 Jul 25

Ito F, Awasaki T.

225. Quantitative texture analysis based on dynamic contrast enhanced MRI for differential diagnosis between primary thymic lymphoma from thymic carcinoma.

Sci Rep

2022 Jul 24

Zhu JJ(#), Shen J(#), Zhang W

226. Relationship between anatomical characteristics and personality traits in Lipizzan horses.

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2022 Jul 23

Debeljak N, Košmerlj A, Altimiras J

227. Prevalence and correlates of burnout among physicians in a developing country facing multi-layered crises: a cross-sectional study.

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2022 Jul 23

Youssef D, Youssef J, Abou-Abbas L

228. Associations between non-alcoholic fatty liver disease and cognitive impairment and the effect modification of inflammation.

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2022 Jul 23

Kang S, Kim E, Cho H

229. Metabolic signatures associated with oncolytic myxoma viral infections.

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2022 Jul 23

Mahar R(#), Ragavan M(#), Chang MC(#)

230. Modulation of atrazine-induced chromosomal aberrations and cyclin-dependent kinases by aqueous extract of Roylea cinerea (D.Don) Baillon leaves in Allium cepa.

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2022 Jul 22

Rashid F, Singh D, Attri S

231. Discrimination of Curculigo orchioides Rhizoma and Curculigo glabrescens Rhizoma using stable isotope and mineral element analyses coupled with chemometrics.

Sci Rep

2022 Jul 22

Liu Y(#), Guo Y(#), Gong S

232. Glycometabolism change during Burkholderia pseudomallei infection in RAW264.7 cells by proteomic analysis.

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2022 Jul 22

Li X, Zeng Y, Guo S

233. Mechanical properties of friction induced nanocrystalline pearlitic steel.

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2022 Jul 22

Medina-Clavijo B, Rafael-Velayarce J, Modin E

234. Limited generalizability of single deep neural network for surgical instrument segmentation in different surgical environments.

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2022 Jul 22

Kitaguchi D, Fujino T, Takeshita N

235. Smooth muscle cell specific NEMO deficiency inhibits atherosclerosis in ApoE(-/-) mice.

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2022 Jul 22

Imai T, Van TM, Pasparakis M

236. Antibody CDR amino acids underlying the functionality of antibody repertoires in recognizing diverse protein antigens.

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2022 Jul 22

Peng HP, Hsu HJ, Yu CM

237. Robust osteogenic efficacy of 2α-heteroarylalkyl vitamin D analogue AH-1 in VDR (R270L) hereditary vitamin D-dependent rickets model rats.

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2022 Jul 22

Nishikawa M, Murose N, Mano H

238. Spaceborne NO(2) observations are sensitive to coal mining and processing in the largest coal basin of Russia.

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2022 Jul 22

Labzovskii LD, Belikov DA, Damiani A.

239. The molecular heterogeneity of the precancerous breast affects drug efficacy.

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2022 Jul 22

Bhardwaj A, Rojo RD, Ju Z

240. Optimal control for a SIR epidemic model with limited quarantine.

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2022 Jul 22

Balderrama R, Peressutti J, Pinasco JP

241. Wheat transcriptomic responses to extended feeding by wheat curl mites.

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2022 Jul 22

Pingault L(#), Luong TKN(#), Louis J

242. Blockade of CD47 enhances the antitumor effect of macrophages in renal cell carcinoma through trogocytosis.

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2022 Jul 22

Park HR, Kim SE, Keam B

243. Thermal fluid fields reconstruction for nanofluids convection based on physics-informed deep learning.

Sci Rep

2022 Jul 22

Li Y, Liu T, Xie Y.

244. Engineered chimeric insecticidal crystalline protein improves resistance to lepidopteran insects in rice (Oryza sativa L.) and maize (Zea mays L.).

Sci Rep

2022 Jul 22

Liu Y(#), Han S(#), Yang S

245. Structure-based prediction of BRAF mutation classes using machine-learning approaches.

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2022 Jul 22

Krebs FS, Britschgi C, Pradervand S

246. Experimental and numerical study of steady state stability in a toluene biodegrading biofilter.

Sci Rep

2022 Jul 22

Süß M, De Visscher A.

247. An in silico approach to study the role of epitope order in the multi-epitope-based peptide (MEBP) vaccine design.

Sci Rep

2022 Jul 22

Salaikumaran MR, Kasamuthu PS, Aathmanathan VS

With different countries facing multiple waves, with some SARS-CoV-2 variants more deadly and virulent, the COVID-19 pandemic is becoming more dangerous by the day and the world is facing an even more dreadful extended pandemic with exponential positive cases and increasing death rates. There is an urgent need for more efficient and faster methods of vaccine development against SARS-CoV-2. Compared to experimental protocols, the opportunities to innovate are very high in immunoinformatics/in silico approaches, especially with the recent adoption of structural bioinformatics in peptide vaccine design. In recent times, multi-epitope-based peptide vaccine candidates (MEBPVCs) have shown extraordinarily high humoral and cellular responses to immunization. Most of the publications claim that respective reported MEBPVC(s) assembled using a set of in silico predicted epitopes, to be the computationally validated potent vaccine candidate(s) ready for experimental validation. However, in this article, for a given set of predicted epitopes, it is shown that the published MEBPVC is one among the many possible variants and there is high likelihood of finding more potent MEBPVCs than the published candidates. To test the same, a methodology is developed where novel MEBP variants are derived by changing the epitope order of the published MEBPVC. Further, to overcome the limitations of current qualitative methods of assessment of MEBPVC, to enable quantitative comparison and ranking for the discovery of more potent MEBPVCs, novel predictors, Percent Epitope Accessibility (PEA), Receptor specific MEBP vaccine potency (RMVP), MEBP vaccine potency (MVP) are introduced. The MEBP variants indeed showed varied MVP scores indicating varied immunogenicity. Further, the MEBP variants with IDs, SPVC_446 and SPVC_537, had the highest MVP scores indicating these variants to be more potent MEBPVCs than the published MEBPVC and hence should be preferred candidates for immediate experimental testing and validation. The method enables quicker selection and high throughput experimental validation of vaccine candidates. This study also opens the opportunity to develop new software tools for designing more potent MEBPVCs in less time.

248. Standardization and quantitative analysis of Araucaria Heterophylla extract via an UPLC-MS/MS method and its formulation as an antibacterial phytonanoemulsion gel.

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2022 Jul 22

Younis NA, Hemdan A, Zafer MM

249. A new L-shaped rigid beam FBG acceleration sensor.

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2022 Jul 22

Teng Y, Wang Y, Tang Y

250. Process optimization and technoeconomic environmental assessment of biofuel produced by solar powered microwave pyrolysis.

Sci Rep

2022 Jul 22

Fodah AEM, Abdelwahab TAM.

251. Demonstration of a new entity of non-perforated appendicitis through studying cluster of appendicitis.

Sci Rep

2022 Jul 21

Guo Y, Ye D, Yang G

252. Carboxylic acids derived from triacylglycerols that contribute to the increase in acid value during the thermal oxidation of oils.

Sci Rep

2022 Jul 21

Sakaino M, Sano T, Kato S

253. Decision effect of a deep-learning model to assist a head computed tomography order for pediatric traumatic brain injury.

Sci Rep

2022 Jul 21

Heo S, Ha J, Jung W

254. All organic homojunction PEDOT:PSS p-n diode.

Sci Rep

2022 Jul 21

Aboulhadeed S, Ghali M, Ayad MM.

255. Rapid and sensitive detection of ovarian cancer biomarker using a portable single peak Raman detection method.

Sci Rep

2022 Jul 21

Moothanchery M(#), Perumal J(#), Mahyuddin AP

256. Forecast of a future leveling of the incidence trends of female breast cancer in Taiwan: an age-period-cohort analysis.

Sci Rep

2022 Jul 21

Chen YC, Su SY, Jhuang JR

257. Reliability and accuracy of straightforward measurements for liver volume determination in ultrasound and computed tomography compared to real volumetry.

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2022 Jul 21

Seppelt D, Kromrey ML, Ittermann T

258. A joint learning approach for genomic prediction in polyploid grasses.

Sci Rep

2022 Jul 21

Aono AH, Ferreira RCU, Moraes ADCL

259. Prognostic value of molecular cytology by one-step nucleic acid amplification (OSNA) assay of peritoneal washings in advanced gastric cancer patients.

Sci Rep

2022 Jul 21

Gęca K(#), Skórzewska M(#), Rawicz-Pruszyński K

260. Wildfire plumes in the Western US are reaching greater heights and injecting more aerosols aloft as wildfire activity intensifies.

Sci Rep

2022 Jul 20

Wilmot TY, Mallia DV, Hallar AG

261. Investigation of the correlation between diabetic retinopathy and prevalent and incident migraine in a national cohort study.

Sci Rep

2022 Jul 20

Vergmann AS, Stokholm L, Rubin KH

262. Development of a rapid in vitro pre-screen for distinguishing effective liposome-adjuvant delivery systems.

Sci Rep

2022 Jul 20

Feather LAJ, Nadella V, Kastner E

263. Cryopreservation of six Symbiodiniaceae genera and assessment of fatty acid profiles in response to increased salinity treatments.

Sci Rep

2022 Jul 20

Kihika JK, Wood SA, Rhodes L

264. The effect of metformin on the survival of colorectal cancer patients with type 2 diabetes mellitus.

Sci Rep

2022 Jul 20

Tarhini Z, Manceur K, Magne J

265. Comparing the clinical utility of single-shot, readout-segmented and zoomit echo-planar imaging in diffusion-weighted imaging of the kidney at 3 T.

Sci Rep

2022 Jul 20

Liu W(#), Liu H(#), Xie S

We compared the clinical utility of single-shot echo-planar imaging (SS-EPI) using different breathing schemes, readout-segmented EPI and zoomit EPI in the repeatability of apparent diffusion coefficient (ADC) measurements, cortico-medullary contrast to noise ratio (c-mCNR) and image quality. In this institutional review board-approved prospective study, some common clinically applicable diffusion-weighted imaging (b = 50, 400, 800 s/mm2) of kidney on 3.0 T MRI were performed on 22 volunteers using SS-EPI with breath-hold diffusion-weighted imaging (BH-DWI), free-breathing (FB-DWI), navigator-triggered (NT-DWI) and respiratory-triggered (RT-DWI), readout-segmented DWI (RS-DWI), and Zoomit DWI (Z-DWI). ADC and c-mCNR were measured in 12 anatomic locations (the upper, middle, and lower pole of the renal cortex and medulla), and image quality was assessed on these DWI sequences. A DWI with the optimal clinical utility was decided by systematically assessing the ADC repeatability, c-mCNR and image quality among the DWIs. For ADC measurements, Z-DWI had an excellent intra-observer agreement (intra-class correlation coefficients (ICCs): 0.876-0.944) and good inter-observer agreement (inter-class ICCs: 0.798-0.856) in six DWI sequences. Z-DWI had the highest ADC repeatability in most of the 12 anatomic locations of the kidneys (mean ADC absolute difference: 0.070-0.111 × 10-3 mm2/s, limit of agreement: 0.031-0.056 × 10-3 mm2/s). In all DWIs, Z-DWI yielded a slightly higher c-mCNR than other DWIs in most representative locations (P > 0.05), which was significantly higher than BH-DWI and FB-DWI in the middle pole of both kidneys and the upper pole of the left kidney (P < 0.05). In addition, Z-DWI yielded image quality that was similar to RT-DWI and NT-DWI (P > 0.05) and superior to BH-DWI, FB-DWI and RS-DWI (P < 0.05). Our results suggest that Z-DWI provides the highest ADC reproducibility, better c-mCNR and good image quality on 3.0 T MRI, making it the recommended sequence for clinical DWI of the kidney.

266. Repatriation of a historical North Atlantic right whale habitat during an era of rapid climate change.

Sci Rep

2022 Jul 20

O'Brien O, Pendleton DE, Ganley LC

267. Immunomodulatory activity of extracts from five edible basidiomycetes mushrooms in Wistar albino rats.

Sci Rep

2022 Jul 20

Elhusseiny SM, El-Mahdy TS, Elleboudy NS

Mushrooms are nutritious foods that are widely cultivated all over the world. They are rich in a range of compounds linked to improving functions of the immune system including carotenoids, alkaloids, lectins, enzymes, folates, fats, organic acids, minerals, polysaccharides, phenolics, proteins, tocopherols, terpenoids, and volatile compounds. In this study we investigated, the immunomodulatory activity in rats of the aqueous extracts of five of the most common edible mushrooms belonging to Family Basidiomycota-white-rot fungi including, Lentinula edodes, Agaricus bisporus, Pleurotus ostreatus, Pleurotus columbinus, and Pleurotus sajor-caju. Male Wistar albino rats were assigned to thirteen groups and Immunosuppression was induced by oral administration of dexamethasone (0.1 mg/kg), followed by oral administration of the mushroom extracts at low (200 mg/kg) and high (400 mg/kg) doses. A positive control group received the immune stimulant Echinacea extract Immulant® at (30 mg/kg), while the negative control group received only saline. From each animal, in each group, blood samples were collected after 15 days for complete blood counts and for measurement of immunologic parameters, including lysozyme activity, nitric oxide (NO) production and serum cytokines including tumor necrosis factor-alpha (TNF-α), interferon-gamma (IFN-γ) and interleukin 1 beta (IL-1β) levels. Results have shown that white blood cells (WBCs) and lymphocytic counts were significantly boosted by high doses of each of the five mushroom extracts (207-289% increase for WBC and 153-175% for lymphocytes) with a significant increase in lysozyme activity (110-136% increase), NO concentration (159-232% increase) and cytokines as compared to the negative control group. Histopathological examination of the rats' spleen and thymus tissues has shown marked lymphocytic proliferation that was more obvious at the higher doses. In conclusion, our results showed that the five edible mushroom extracts revealed significant immunostimulatory effects preclinically particularly, at the higher doses (400 mg/kg) which can be considered the effective dose.

268. Association of serum s-adenosylmethionine, s-adenosylhomocysteine, and their ratio with the risk of dementia and death in a community.

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2022 Jul 20

Mihara A, Ohara T, Hata J

269. Current use of D-dimer for the exclusion of venous thrombosis in hospitalized patients.

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2022 Jul 20

Karny-Epstein N, Abuhasira R, Grossman A.

270. The fusion-fission optimization (FuFiO) algorithm.

Sci Rep

2022 Jul 20

Nouhi B, Darabi N, Sareh P

271. Eolian erosion of polygons in the Atacama Desert as a proxy for hyper-arid environments on Earth and beyond.

Sci Rep

2022 Jul 20

Sager C, Airo A, Arens FL

272. Modelling the interplay of SARS-CoV-2 variants in the United Kingdom.

Sci Rep

2022 Jul 20

Barreiro NL, Govezensky T, Ventura CI

273. Controlled release of vitamin D(3) using a nanocellulose-based membrane.

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2022 Jul 20

Colturato PL, Goveia D.

274. Resistance to grain protectants and synergism in Pakistani strains of Sitophilus oryzae (Coleoptera: Curculionidae).

Sci Rep

2022 Jul 20

Khan T, Haider MS, Khan HAA.

The widespread use of insecticides for the management of insect pests in storage facilities and food industries have caused insecticide resistance a frequent issue worldwide. Nonetheless, this issue has been little explored in Pakistan that resulted in control failures and increased dosage of insecticides. In the present study, insecticide resistance to chlorpyrifos-methyl, pirimiphos-methyl, permethrin and spinosad was surveyed in five field strains of Sitophilus oryzae: FSD-SO, GJR-SO, DGK-SO, MTN-SO and BWP-SO, collected from five different localities of Punjab, Pakistan, and contrasted with an insecticide susceptible reference strain (Lab-SO). Dose-mortality bioassays were performed in glass vials containing insecticide-treated rice grains, and lethal doses (LD50 and LD95) were calculated and compared using the ratio tests. In comparison to the Lab-SO strain at LD50 and LD95 levels, field strains exhibited: 24.51 to 52.80 and 36.55 to 69.31 resistance ratios (RRs), respectively, for chlorpyrifos-methyl; 15.89 to 45.97 and 55.12 to 194.93 RRs, respectively, for pirimiphos-methyl; 39.76 to 108.61 and 61.33 to 130.12 RRs, respectively, for permethrin; 4.23 to 27.50 and 6.28 to 41.00 RRs, respectively, for spinosad. In the synergism experiments using the Lab-SO and the most resistant strains against each insecticide, the enzyme inhibitors (PBO and DEF) failed to synergize toxicity of insecticides in the Lab-SO strain; however, toxicity of chlorpyrifos-methyl, pirimiphos-methyl and permethrin significantly enhanced in the resistant strains of S. oryzae, suggesting possibility of metabolic mechanism of resistance. In addition, activities of detoxification enzymes (CarE, MFO and GST) were significantly higher in resistant strains compared to the Lab-SO strain. The results revealed presence of insecticide resistance in field strains of S. oryzae that necessitate the need to develop a resistance management strategy.

275. Weakened pacific overturning circulation, winter monsoon dominance and tectonism re-organized Japan Sea paleoceanography during the Late Miocene global cooling.

Sci Rep

2022 Jul 20

Matsuzaki KM, Ikeda M, Tada R.

The Late Miocene global cooling (LMGC; approximately 7.9-5.8 Ma) was associated with remarkable changes in monsoon dynamics, biogenic bloom in the global oceans, and the rise of modern ecosystems at the expense of old biota. However, the possible linkage between the environmental changes and ecosystem shifts during the LMGC is still debated. In this paper, we show the high-resolution changes in the fluxes of selected radiolarian species, suggesting a drastic reorganization in the paleoceanography and ecosystem in the Japan Sea during the LMGC. The endemic radiolarian Cycladophora nakasekoi dominated the Japan Sea until 7.4 Ma when the Japan Sea sediment changed from dark radiolarian-rich sediment to organic-poor diatom ooze. Changes in the fluxes of C. nakasekoi and Tricolocapsa papillosa, the latter related to changes in the Pacific central water (PCW), show 100, 200, and ~ 500 ka cycles with their high flux mostly within the darker sediment intervals during the low-eccentricity period until 7.4 Ma, suggesting that orbitally paced PCW inflow might have been the major nutrient source into the Japan Sea. At about 7.4 Ma, these species decreased at the expense of increased Larcopyle weddellium, a radiolarian related to the North Pacific intermediate water (NPIW), and Cycladophora sphaeris, a subarctic radiolarian species, implying a decrease in PCW inflow and an increase in the inflow of NPIW and subarctic shallow water. Such a change would have been related to the LMGC-induced weakening in the Pacific Meridional overturning circulation and the southward shift of the subarctic front due to intensified East Asian winter monsoon. Such a drastic reorganization in the hydrography in the Japan Sea probably caused changes in nutrient provenance from the PCW to the NPIW and resulted in faunal turnover, marked by the disappearance of the old regional and endemic faunal components, such as C. nakasekoi.

276. Locomotion of an untethered, worm-inspired soft robot driven by a shape-memory alloy skeleton.

Sci Rep

2022 Jul 20

Xu L(#), Wagner RJ(#), Liu S(#)

277. Sexual practices and HPV infection in unvaccinated young adults.

Sci Rep

2022 Jul 20

Pauli S, Kops NL, Bessel M

278. The value of social interactions and incentives on the use of a digital contact tracing tool post COVID-19 lockdown in Singapore.

Sci Rep

2022 Jul 20

Huang Z, Guo H, Lim HY

279. Net greenhouse gas balance with cover crops in semi-arid irrigated cropping systems.

Sci Rep

2022 Jul 20

Acharya P, Ghimire R, Paye WS

280. A clinical trial of a patient-customized virtual reality intervention for tinnitus.

Sci Rep

2022 Jul 20

Park DH(#), Han SS(#), Han M

Virtual reality (VR) has recently been used as a clinical treatment because it can efficiently simulate situations that are difficult to control in real-world settings. In our study, we assessed the potential of VR in patients with chronic subjective tinnitus. An evaluation of its clinical benefits was performed based on analyses of patient electroencephalograms (EEGs) and by questionnaire responses after 6-8 weeks of patient involvement in our VR-based alleviation program. Clinical trials were performed at a tertiary academic hospital. Nineteen patients (aged 33-64 years) who visited our hospital with chronic subjective tinnitus over 3 months were enrolled in the study. The intervention consisted of trashing the tinnitus avatar in VR. We expected that the patients would have the subjective feeling of controlling tinnitus through our intervention. The VR environment comprised four different sessions in four different settings: a bedroom, a living room, a restaurant, and a city street. We analyzed changes in the source activities of the prefrontal regions related to tinnitus in these patients using standardized low-resolution brain electromagnetic tomography. The Tinnitus Handicap Inventory (THI), the total score (from 50.11 to 44.21, P = 0.046) and the grade (from 3.16 to 2.79, P = 0.035) were significantly improved after the VR-based tinnitus treatment program (P < 0.05). The Pittsburgh Sleep Quality Index also showed improved outcomes (P = 0.025). On the other hand, a Tinnitus Handicap Questionnaire, Quality of Life Assessment (WHO-QOL), Hospital Anxiety and Depression Scale, Profile of Mood States revealed no significant change after the intervention. The baseline EEG data showed that brain activity in the orbitofrontal cortex significantly increased in the alpha and theta frequency bands. Furthermore, patients who showed a THI score improvement after the intervention showed specific increases in brain activity for the theta and high beta bands in the orbitofrontal cortex. Our findings suggest that the virtual reality-based program, as in parts of cognitive behavioral treatment, may help to alleviate tinnitus-related distress in patients with chronic subjective tinnitus.

281. Comparing two different automatic methods to measure femoral neck-shaft angle based on PointNet++ network.

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2022 Jul 20

Li Z(#), Yang J(#), Li X

282. Relationship between hyperhomocysteinemia and coexisting obesity with low skeletal muscle mass in asymptomatic adult population.

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2022 Jul 20

Yoo TK(#), Rhim HC(#), Lee YT

283. Mirabegron and solifenacin are effective for the management of the increased urinary frequency induced by psychological stress in female mice.

Sci Rep

2022 Jul 20

West EG, McDermott C, Chess-Williams R

284. Evaluation of early innate and adaptive immune responses to the TB vaccine Mycobacterium bovis BCG and vaccine candidate BCGΔBCG1419c.

Sci Rep

2022 Jul 20

Gunasena M, Shukla RK, Yao N

285. Cone penetration index for soil behaviour type prediction.

Sci Rep

2022 Jul 20

Sodré DJR.

286. Clearance and persistence of Escherichia coli in the freshwater mussel Unio mancus.

Sci Rep

2022 Jul 20

Campos M, Lobato-Bailón L, Merciai R

287. Microinvasive breast cancer and the role of sentinel lymph node biopsy.

Sci Rep

2022 Jul 20

Hacking SM, Leonard KL, Wu D

288. Transition of a small Himalayan glacier lake outburst flood to a giant transborder flood and debris flow.

Sci Rep

2022 Jul 20

Sattar A, Haritashya UK, Kargel JS

Glacial lake outburst floods (GLOFs) are a great concern for the Himalaya, as they can severely damage downstream populations and infrastructures. These floods originate at high altitudes and can flow down with enormous energy and change the terrain's existing morphology. One such devastating event occurred on the night of 5 July 2016, from the inconspicuous Gongbatongsha Lake, located in the Poiqu basin, Eastern Himalaya. The Poiqu basin in the Tibetan Autonomous Region currently contains numerous big glacial lakes; however, this event originated from a small lake. The GLOF was triggered following heavy precipitation that led to a slope failure above the lake and deposition of debris into the lake, which breached the moraine dam and rapidly drained the entire lake. The flood damaged several downstream infrastructures, including the Arniko highway, the Upper Bhotekoshi hydropower plant, and several buildings as it made its way into the Bhotekoshi basin in Nepal. This study adopts a multi-model approach to reconstruct the GLOF trigger and the flood's transformation into a severe debris flow. Proxies including flow discharge, flow velocity, runout distances were used to calibrate the model and validate the results. Results reveal that a debris flow of volume ranging between 3000 and 6000 m3 from the headwall must have led to lake overfill, eventually leading to the GLOF event. The GLOF showed a significant increase in peak discharge from 618 to 4123 m3 s-1 at the Zhangzangbo-Bhotekoshi confluence. The average velocity of the flow is calculated to be ~ 5.5 m s-1. Reconstruction of the erosion and deposition dynamics show that maximum erosion occurred in the first 6.5 km, with maximum deposition occurring near the Upper Bhotekoshi hydropower station. The modeling indicates that the availability of the entrainable debris along the channel, likely from the previous landslides, amplified the event by three orders of magnitude-additional water ingested from the river. Overall, we demonstrate how the small-scale Gongbatongsha GLOF amplified downstream by incorporating pre-existing sediment in the valley and triggered damaging secondary landslides leading to an economic loss of > 70 million USD.

289. Genetic dissection of grain iron and zinc, and thousand kernel weight in wheat (Triticum aestivum L.) using genome-wide association study.

Sci Rep

2022 Jul 20

Krishnappa G, Khan H, Krishna H

290. Transcriptome analysis of human cholangiocytes exposed to carcinogenic 1,2-dichloropropane in the presence of macrophages in vitro.

Sci Rep

2022 Jul 2

Ekuban A, Shichino S, Zong C

291. Multi-scale electronics transport properties in non-ideal CVD graphene sheet.

Sci Rep

2022 Jul 2

Bishnoi B, Buerkle M, Nakamura H.

292. Human enteric adenovirus F40/41 as a major cause of acute gastroenteritis in children in Brazil, 2018 to 2020.

Sci Rep

2022 Jul 2

do Nascimento LG, Fialho AM, de Andrade JDSR

293. Hypertension and diabetes including their earlier stage are associated with increased risk of sudden cardiac arrest.

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2022 Jul 19

Kim YG(#), Roh SY(#), Han KD

294. Activation function 1 of progesterone receptor is required for mammary development and regulation of RANKL during pregnancy.

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2022 Jul 19

Lee SH(#), Yap YHY(#), Lim CL

295. Automatic parameter selection for electron ptychography via Bayesian optimization.

Sci Rep

2022 Jul 19

Cao MC, Chen Z, Jiang Y

296. Tibial sagittal and rotational alignment reduce patellofemoral stresses in posterior stabilized total knee arthroplasty.

Sci Rep

2022 Jul 19

Mizu-Uchi H, Ma Y, Ishibashi S

297. A simple proteinuria-based risk score predicts contrast-associated acute kidney injury after percutaneous coronary intervention.

Sci Rep

2022 Jul 19

Fujiwara W, Ishii H, Sobue Y

298. Comparison of three imaging and navigation systems regarding accuracy of pedicle screw placement in a sawbone model.

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2022 Jul 19

Beisemann N, Gierse J, Mandelka E

299. Rapid high-resolution volumetric imaging via laser ablation delayering and confocal imaging.

Sci Rep

2022 Jul 19

Phoulady A(#), May N(#), Choi H(#)

300. 2-hydroxyethyl methacrylate-derived reactive oxygen species stimulate ATP release via TRPA1 in human dental pulp cells.

Sci Rep

2022 Jul 19

Orimoto A, Kitamura C, Ono K.

301. Identification of FAT3 as a new candidate gene for adolescent idiopathic scoliosis.

Sci Rep

2022 Jul 19

Nada D, Julien C, Papillon-Cavanagh S

302. Development of Ag(0.04)ZrO(2)/rGO heterojunction, as an efficient visible light photocatalyst for degradation of methyl orange.

Sci Rep

2022 Jul 19

Iqbal RMA, Akhtar T, Sitara E

303. Fluorescence and UV-visible reflectance in the fur of several Rodentia genera.

Sci Rep

2022 Jul 19

Sobral G, Souza-Gudinho F.

304. Effects of etomidate combined with dexmedetomidine on adrenocortical function in elderly patients: a double-blind randomized controlled trial.

Sci Rep

2022 Jul 19

Wang F, Yang Z, Zeng S

305. Allogeneic MHC-matched T-cell receptor α/β-depleted bone marrow transplants in SHIV-infected, ART-suppressed Mauritian cynomolgus macaques.

Sci Rep

2022 Jul 19

Weinfurter JT(#), D'Souza SS(#), Matschke LM

306. Genomic epidemiology of SARS-CoV-2 in a university outbreak setting and implications for public health planning.

Sci Rep

2022 Jul 19

Nickbakhsh S(#), Hughes J(#), Christofidis N

307. Class I PI3K regulatory subunits control differentiation of dendritic cell subsets and regulate Flt3L mediated signal transduction.

Sci Rep

2022 Jul 19

Thummar K, Rathinam CV.

308. Long-term anti-tumor effects following both conventional radiotherapy and FLASH in fully immunocompetent animals with glioblastoma.

Sci Rep

2022 Jul 19

Liljedahl E, Konradsson E, Gustafsson E

309. 3D food printing improves color profile and structural properties of the derived novel whole-grain sourdough and malt biscuits.

Sci Rep

2022 Jul 19

Kewuyemi YO, Kesa H, Meijboom R

310. The high-pressure lithium-palladium and lithium-palladium-hydrogen systems.

Sci Rep

2022 Jul 19

Frost M, McBride EE, Smith JS

311. Validation of Sport Anxiety Scale-2 (SAS-2) among Polish athletes and the relationship between anxiety and goal orientation in sport.

Sci Rep

2022 Jul 19

Tomczak M, Kleka P, Walczak A

312. Experimental study on deformation characteristics and pore characteristics variation of granite residual soil.

Sci Rep

2022 Jul 19

Yin S, Huang J, Li X

313. Methods for stroke severity assessment by chart review in the Atherosclerosis Risk in Communities study.

Sci Rep

2022 Jul 19

Koton S, Patole S, Carlson JM

Stroke severity is the most important predictor of post-stroke outcome. Most longitudinal cohort studies do not include direct and validated measures of stroke severity, yet these indicators may provide valuable information about post-stroke outcomes, as well as risk factor associations. In the Atherosclerosis Risk in Communities (ARIC) study, stroke severity data were retrospectively collected, and this paper outlines the procedures used and shares them as a model for assessment of stroke severity in other large epidemiologic studies. Trained physician abstractors, who were blinded to other clinical events, reviewed hospital charts of all definite/probable stroke events occurring in ARIC. In this analysis we included 1,198 ischemic stroke events occurring from ARIC baseline (1987-1989) through December 31, 2009. Stroke severity was categorized according to the National Institutes of Health Stroke Scale (NIHSS) score and classified into 5 levels: NIHSS ≤ 5 (minor), NIHSS 6-10 (mild), NIHSS 11-15 (moderate), NIHSS 16-20 (severe), and NIHSS > 20 (very severe). We assessed interrater reliability in a subgroup of 180 stroke events, reviewed independently by the lead abstraction physician and one of the four secondary physician abstractors. Interrater correlation coefficients for continuous NIHSS score as well as percentage of absolute agreement and Cohen Kappa Statistic for NIHSS categories were presented. Determination of stroke severity by the NIHSS, based on data abstracted from hospital charts, was possible for 97% of all ischemic stroke events. Median (25%-75%) NIHSS score was 5 (2-8). The distribution of NIHSS category was NIHSS ≤ 5 = 58.3%, NIHSS 6-10 = 24.5%, NIHSS 11-15 = 8.9%, NIHSS 16-20 = 4.7%, NIHSS > 20 = 3.6%. Overall agreement in the classification of severity by NIHSS category was present in 145/180 events (80.56%). Cohen's simple Kappa statistic (95% CI) was 0.64 (0.55-0.74) and weighted Kappa was 0.79 (0.72-0.86). Mean (SD) NIHSS score was 5.84 (5.88), with a median score of 4 and range 0-31 for the lead reviewer (rater 1) and mean (SD) 6.16 (6.10), median 4.5 and range 0-36 in the second independent assessment (rater 2). There was a very high correlation between the scores reported in both assessments (Pearson r = 0.90). Based on our findings, we conclude that hospital chart-based retrospective assessment of stroke severity using the NIHSS is feasible and reliable.

314. Prediction and experimental evidence of the optimisation of the angular branching process in the thallus growth of Podospora anserina.

Sci Rep

2022 Jul 19

Ledoux C, Chapeland-Leclerc F, Ruprich-Robert G

315. Connecting nutritional facts with the traditional ranking of ethnobotanically used fodder grasses by local farmers in Central Punjab of Pakistan.

Sci Rep

2022 Jul 19

Harun N(#), Chaudhry AS(#), Shaheen S

The local farmers of Central Punjab, Pakistan have been using indigenous grasses as vital components of ruminant diets, but little is reported about their nutritional potential. Hence this study investigated nutritive potential of a selection of ethnobotanically important fodder grasses. Multiple nutritional parameters (proximate components, fibre fractions), secondary metabolites (phenolics, tannins) and in vitro digestibility values were determined. Furthermore, the legitimacy of ethnobotanical knowledge of local inhabitants about these grasses was also verified. The results suggested that majority (77%) of these grasses can be regarded as good quality fodders because of their high protein (169 g/kg) and good digestibility (457 g/kg) with moderate fibre (≤ 602 g/kg), lignin (≤ 50 g/kg) and secondary metabolites (total phenols ≤ 87 g/kg, total tannins ≤ 78 g/kg, condensed tannins ≤ 61 g/kg). Pearson correlation between nutritional parameters indicated that in vitro digestibility values were positively correlated with crude proteins (IVDMD, r = + 0.83 and IVOMD, r = + 0.83 respectively) and negatively correlated with fibre (NDF, r = - 0.91), ADF, r = - 0.84 and ADL, r = - 0.82) contents. Moreover, a positive relationship was identified between ethnobotanical knowledge and laboratory findings for studied grasses. Spearman correlation test showed that ranking of grasses based on ethnobotanical preferences were highly correlated (r values) with the laboratory results for CP (0.85), NDF (- 0.76), ADF (- 0.72) and ADL (- 0.62). The resilient complementarities between ethnobotanical preferences and nutritive analysis authenticate farmer's traditional knowledge, which needed to be aligned with the corresponding scientific data. Farmers can use these findings for appropriate fodder selection and development of precise supplements for feeding ruminants within a sustainable and economically viable livestock industry for food security.

316. PDA modification and properties of α-AlH(3).

Sci Rep

2022 Jul 19

Qin M, Yao B, Shi Q

317. Offset-decoupled deformable convolution for efficient crowd counting.

Sci Rep

2022 Jul 18

Zhong X, Qin J, Guo M

318. A randomized, placebo-controlled clinical trial evaluating of a mouthwash containing Sambucus williamsii var. coreana extract for prevention of gingivitits.

Sci Rep

2022 Jul 18

Kim YR, Nam SH.

The purpose of this study is to verify the clinical applicability by applying a mouthwash containing Sambucus williamsii var. coreana extract for preventing periodontal disease. A randomized, double-blind, placebo-controlled study was conducted on 64 patients, excluding those with insufficient data, who visited M dental clinic located in Busan, Korea. Thirty-two people were assigned respectively to the saline solution gargle group and the Sambucus williamsii var. coreana extract gargle group to conduct the O'Leary index, plaque index (PI), gingival index (GI), and subgingival plaques. For the homogeneity of the two groups, scaling was carried out one week before the experiment, and the participants were taught for oral care to conduct during the study period. SPSS 24.0 for Windows (IBM Corp., Armonk, NY, USA) was used to compare the saline solution gargle group and the Sambucus williamsii var. coreana extract gargle group as well as to analyze Baseline (before gargle application), Treatment (immediately after gargle application), and After 5 Days (5 days after gargle application). There was a significant difference in the O'Leary index, PI, GI and subgingival plaques after Treatment and After 5 days (p < 0.05). Also, the periodontal-related indexes improved as the application time increased in the Sambucus williamsii var. coreana extract gargle group. The antibacterial effect was also shown for gram-positive bacteria and gram-negative bacteria in subgingival plaques as the application time increased. The use of the mouthwash containing Sambucus williamsii var. coreana extract was found to be effective for oral periodontal-related indicators and bacteria causing periodontal disease. Therefore, using a mouthwash containing Sambucus williamsii var. coreana extract, a natural drug, will possibly maintain healthy periodontal health by inhibiting and preventing the progression of periodontal disease.

319. An experimental and theoretical characterization of the electronic structure of doubly ionised disulfur.

Sci Rep

2022 Jul 18

Olsson E, Ayari T, Ideböhn V

320. A retrospective cohort study of factors associated with severity of falls in hospital patients.

Sci Rep

2022 Jul 18

Ghosh M, O'Connell B, Afrifa-Yamoah E

Severity of falls in hospital patients are threat to patient safety which can result in a financial burden on the patient's family and health care services. Both patient specific and environmental and organisational factors are associated with severity of falls in hospital. It is important to continuously analyse the factors associated with severity of fall which can inform the implementation of any fall preventive strategies. This study aims to identify factors associated with the severity of falls in hospitalised adult patients in Western Australia. This study involved a retrospective cohort analysis of inpatient falls records extracted from the hospital's Clinical Incident Database from May 2014 to April 2019. Severity of falls were classified as three Severity Assessment Code (SAC): SAC 1 was "high" causing serious harm or death; SAC 2 was "medium" causing moderate or minor harm; and SAC 3 was "low" indicating no harm. Univariable and multivariable generalised ordinal logistic regression models were used to quantify the magnitude of effects of the potential risk factors on severity of falls at 5% level of significance and reported the crude odds and adjusted odds ratio of falling at a higher severity level. There were 3705 complete reported cases of falls with the average age of the patients was 68.5 ± 17.0 years, with 40.2% identified as female. The risk of falling at a higher level of severity increased by patient age over 50 years. Females were 15.1% more likely to fall at higher severity level compared to females. Fall incidents occurred during toileting and showering activities and incidents in a communal area were 14.5% and 26% more likely to occur at a higher severity respectively. Similarly, depression (167%), influence of alcohol or illicit drugs (more than 300%), use of medications (86%) and fragile skin (75%) significantly increased the odds of falling at higher level of severity. Identification of underlying risk factors associated with fall severity provides information which can guide nurses and clinicians to design and implement effective interventional strategies that mitigate the risk of serious fall injuries. The results suggest that fall prevention strategies should target patients with these risk factors to avoid severity of falls.

321. Domain-level epitope mapping of polyclonal antibodies against HER-1 and HER-2 receptors using phage display technology.

Sci Rep

2022 Jul 18

Pérez-Martínez D, Infante YC, Ramírez BS

322. Cerebral small vessel disease as imaging biomarker predicting ocular cranial nerve palsy of presumed ischemic origin at admission.

Sci Rep

2022 Jul 18

Kang DW, Ha SY, Sung JJ

323. Latency period of PROM at term and the risk of neonatal infectious diseases.

Sci Rep

2022 Jul 18

Zhuang L(#), Li ZK(#), Zhu YF(#)

324. Multi-parametric analyses to investigate dependencies of normal left atrial strain by cardiovascular magnetic resonance feature tracking.

Sci Rep

2022 Jul 18

Eckstein J(#), Körperich H(#), Paluszkiewicz L

325. Artificial intelligence fully automated myocardial strain quantification for risk stratification following acute myocardial infarction.

Sci Rep

2022 Jul 18

Backhaus SJ(#), Aldehayat H(#), Kowallick JT

Feasibility of automated volume-derived cardiac functional evaluation has successfully been demonstrated using cardiovascular magnetic resonance (CMR) imaging. Notwithstanding, strain assessment has proven incremental value for cardiovascular risk stratification. Since introduction of deformation imaging to clinical practice has been complicated by time-consuming post-processing, we sought to investigate automation respectively. CMR data (n = 1095 patients) from two prospectively recruited acute myocardial infarction (AMI) populations with ST-elevation (STEMI) (AIDA STEMI n = 759) and non-STEMI (TATORT-NSTEMI n = 336) were analysed fully automated and manually on conventional cine sequences. LV function assessment included global longitudinal, circumferential, and radial strains (GLS/GCS/GRS). Agreements were assessed between automated and manual strain assessments. The former were assessed for major adverse cardiac event (MACE) prediction within 12 months following AMI. Manually and automated derived GLS showed the best and excellent agreement with an intraclass correlation coefficient (ICC) of 0.81. Agreement was good for GCS and poor for GRS. Amongst automated analyses, GLS (HR 1.12, 95% CI 1.08-1.16, p < 0.001) and GCS (HR 1.07, 95% CI 1.05-1.10, p < 0.001) best predicted MACE with similar diagnostic accuracy compared to manual analyses; area under the curve (AUC) for GLS (auto 0.691 vs. manual 0.693, p = 0.801) and GCS (auto 0.668 vs. manual 0.686, p = 0.425). Amongst automated functional analyses, GLS was the only independent predictor of MACE in multivariate analyses (HR 1.10, 95% CI 1.04-1.15, p < 0.001). Considering high agreement of automated GLS and equally high accuracy for risk prediction compared to the reference standard of manual analyses, automation may improve efficiency and aid in clinical routine implementation.Trial registration: ClinicalTrials.gov, NCT00712101 and NCT01612312.

326. Titania nanospikes activate macrophage phagocytosis by ligand-independent contact stimulation.

Sci Rep

2022 Jul 18

Kartikasari N, Yamada M, Watanabe J

Macrophage phagocytosis is an important research target to combat various inflammatory or autoimmune diseases; however, the phenomenon has never been controlled by artificial means. Titania nanospikes created by alkaline etching treatment can tune macrophage polarization toward a M1-like type and might regulate macrophage phagocytosis. This in vitro study aimed to determine whether the two-dimensional titania nanosurfaces created by alkaline etching treatment activated the macrophage phagocytosis by nanospike-mediated contact stimulation. On two-dimensional pure titanium sheets, alkaline etching treatments with different protocols created superhydrophilic nanosurfaces with hydroxyl function groups and moderate or dense nanospikes. Both types of titania nanosurfaces promoted the phagocytic activity of the mouse macrophage-like cell line, J774A.1, through upregulation of M1 polarization markers and phagocytosis-related receptors, such as toll-like receptors (TLR2 and 4). In contrast, the hydrophobic smooth or micro-roughened titanium surfaces did not activate macrophage phagocytosis or the expression of related receptors. These phenomena remained unchanged even under the antibody blockade of macrophage TLR2 but were either suppressed or augmented for each surface excited by ultraviolet irradiation. Titania nanospikes induced paxillin expression and provided physical stimuli to macrophages, the extent of which was positively correlated with TLR expression levels. Ligand stimulation with lipopolysaccharide did not upregulate macrophage TLR expression but further enhanced M1 marker expression by titania nanosurfaces. These results showed that the two-dimensional titania nanosurfaces activated macrophage phagocytosis by enhancing expression of phagocytosis-related receptors through nanospike-mediated contact stimulation, in assistance with physical surface properties, in a ligand-independent manner.

327. Meta-analytic evidence that mindfulness training alters resting state default mode network connectivity.

Sci Rep

2022 Jul 18

Rahrig H, Vago DR, Passarelli MA

328. Angiogenic gene characterization and vessel permeability of dermal microvascular endothelial cells isolated from burn hypertrophic scar.

Sci Rep

2022 Jul 18

Molina EA, Hartmann B, Oliver MA

329. Microcomputed tomography versus plethysmometer and electronic caliper in the measurements of lymphedema in the hindlimb of mice.

Sci Rep

2022 Jul 18

Bucan A, Wiinholt A, Dalaei F

330. Dynamical stochastic simulation of complex electrical behavior in neuromorphic networks of metallic nanojunctions.

Sci Rep

2022 Jul 18

Mambretti F, Mirigliano M, Tentori E

331. Geographic social inequalities in information-seeking response to the COVID-19 pandemic in China: longitudinal analysis of Baidu Index.

Sci Rep

2022 Jul 18

Wang Z(#), Xiao H(#), Lin L

332. PAI-1 is a potential transcriptional silencer that supports bladder cancer cell activity.

Sci Rep

2022 Jul 16

Furuya H, Sasaki Y, Chen R

333. Electrostatic interactions between single arginine and phospholipids modulate physiological properties of sarcoplasmic reticulum Ca(2+)-ATPase.

Sci Rep

2022 Jul 16

Yamasaki K, Daiho T, Yasuda S

334. Depression is a main determinant of health-related quality of life in patients with diabetic kidney disease.

Sci Rep

2022 Jul 16

Kim S, Jeon J, Lee YJ(#)

335. Deep null fixing on optimal compromise among sum and difference patterns of thinned arrays through the Schelkunoff unit circle representation.

Sci Rep

2022 Jul 16

Raíndo-Vázquez M, Rodríguez-González JA, López-Martín ME

336. Analysis of three-dimensional chromatin packing domains by chromatin scanning transmission electron microscopy (ChromSTEM).

Sci Rep

2022 Jul 16

Li Y(#), Agrawal V(#), Virk RKA(#)

337. Modeling of three dimensional Prandtl hybrid nano-material over a heated rotating cone involving hall and ion slip currents via finite element procedure.

Sci Rep

2022 Jul 16

Sohail M, Nazir U, El-Zahar ER

338. Parameter optimization of PID controller for water and fertilizer control system based on partial attraction adaptive firefly algorithm.

Sci Rep

2022 Jul 16

Huang M, Tian M, Liu Y

339. An experimental investigation of laser scabbling on cement-based materials using nanosecond fiber laser.

Sci Rep

2022 Jul 16

Van Huynh T, Mondal M, Lee D.

340. Younger adults tolerate more relational risks in everyday life as revealed by the general risk-taking questionnaire.

Sci Rep

2022 Jul 16

Law WHC, Yoshino S, Fong CY

341. Reduced dynamic loads due to hip dislocation induce acetabular cartilage degeneration by IL-6 and MMP3 via the STAT3/periostin/NF-κB axis.

Sci Rep

2022 Jul 16

Nakamura Y, Saitou M, Komura S

342. Leveraging whole blood based functional flow cytometry assays to open new perspectives for rheumatoid arthritis translational research.

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2022 Jul 16

Cartagena García C, Balandraud N, Roudier J

343. Effects of solar irradiance noise on a complex marine trophic web.

Sci Rep

2022 Jul 16

Grimaudo R, Lazzari P, Solidoro C

344. A multi-proxy bioarchaeological approach reveals new trends in Bronze Age diet in Italy.

Sci Rep

2022 Jul 16

Varalli A, Moggi-Cecchi J, Goude G.

345. Coenzyme Q10 in the eye isomerizes by sunlight irradiation.

Sci Rep

2022 Jul 15

Mamun MA, Nabi MM, Sato T

346. Transcription-associated DNA DSBs activate p53 during hiPSC-based neurogenesis.

Sci Rep

2022 Jul 15

Michel N, Young HMR, Atkin ND

347. Neural network-based method for diagnosis and severity assessment of Graves' orbitopathy using orbital computed tomography.

Sci Rep

2022 Jul 15

Lee J, Seo W, Park J

348. Relationship between subjective well-being and aripiprazole: an [(11)C]raclopride PET study.

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2022 Jul 15

Kim S, Ock EY, Kwon JS

349. Research on instability characteristics and precursory effect of coal-rock parting-coal structures.

Sci Rep

2022 Jul 15

Liu Y, Wang JH, Lu CP

350. Immigrant background and socioeconomic status are associated with severe COVID-19 requiring intensive care.

Sci Rep

2022 Jul 15

Nordberg P(#), Jonsson M(#), Hollenberg J

351. Periodical assessment of four horns of knee meniscus using MR T2 mapping imaging in volunteers before and after amateur marathons.

Sci Rep

2022 Jul 15

Zhang X(#), Li J(#), Ren C

352. High gain DC/DC converter with continuous input current for renewable energy applications.

Sci Rep

2022 Jul 15

Mansour AS, Amer AH, El-Kholy EE

353. Ultrafast optical control of surface and bulk magnetism in magnetic topological insulator/antiferromagnet heterostructure.

Sci Rep

2022 Jul 15

Liu P, Eckberg C, Pan L

354. Quantification of synthetic errors during chemical synthesis of DNA and its suppression by non-canonical nucleosides.

Sci Rep

2022 Jul 15

Masaki Y, Onishi Y, Seio K.

355. The non-volatile electrostatic doping effect in MoTe(2) field-effect transistors controlled by hexagonal boron nitride and a metal gate.

Sci Rep

2022 Jul 15

Khan MA(#), Khan MF(#), Rehman S

356. The prevalence of psychological stress in student populations during the COVID-19 epidemic: a systematic review and meta-analysis.

Sci Rep

2022 Jul 15

Fang Y, Ji B, Liu Y

Following the COVID-19 outbreak, psychological stress was particularly pronounced in the student population due to prolonged home isolation, online study, closed management, graduation, and employment pressures. The objective of this study is to identify the incidence of psychological stress reactions in student populations following a global outbreak and the associated influencing factors. Four English databases (Pubmed, Embase, Cochrane Library, Web of Science) and four Chinese biomedical databases (Chinese Biomedical Literature Database, VIP Database for Chinese Technical Periodicals, China National Knowledge Infrastructure, Wanfang) were searched in this study. We also retrieved other search engines manually. The search period was from the time of database creation to 10 March 2022. This study included cross-sectional studies related to psychological stress reactions in student populations during the COVID-19 epidemic. Three groups of researchers screened the retrieved studies and assessed the quality of the included studies using the Agency for Healthcare Research and Quality Cross-Sectional Study Quality Assessment Checklist. A random-effects model was used to analyze the prevalence of depression, anxiety, stress, and fear symptoms in the student population during the COVID-19 epidemic. Of the 146,330 records retrieved, we included 104 studies (n = 2,088,032). The quality of included studies was moderate. The prevalence of depressive symptoms in the student population during the epidemic was 32.0% (95% CI [28.0-37.0%]); anxiety symptoms was 28.0% (95% CI [24.0-32.0%]); stress symptoms was 31.0% (95% CI [23.0-39.0%]); and fear symptoms was 33.0% (95% CI [20.0-49.0%]). The prevalence differed by gender, epidemic stage, region, education stage, student major and assessment tool. The prevalence of psychological stress in the student population during the COVID-19 epidemic may be higher compared to the global prevalence of psychological stress. We need to alleviate psychological stress in the student population in a targeted manner to provide mental health services to safeguard the student population.

357. IHACRES, GR4J and MISD-based multi conceptual-machine learning approach for rainfall-runoff modeling.

Sci Rep

2022 Jul 15

Mohammadi B, Safari MJS, Vazifehkhah S.

As a complex hydrological problem, rainfall-runoff (RR) modeling is of importance in runoff studies, water supply, irrigation issues, and environmental management. Among the variety of approaches for RR modeling, conceptual approaches use physical concepts and are appropriate methods for representation of the physics of the problem while may fail in competition with their advanced alternatives. Contrarily, machine learning approaches for RR modeling provide high computation ability however, they are based on the data characteristics and the physics of the problem cannot be completely understood. For the sake of overcoming the aforementioned deficiencies, this study coupled conceptual and machine learning approaches to establish a robust and more reliable RR model. To this end, three hydrological process-based models namely: IHACRES, GR4J, and MISD are applied for runoff simulating in a snow-covered basin in Switzerland and then, conceptual models' outcomes together with more hydro-meteorological variables were incorporated into the model structure to construct multilayer perceptron (MLP) and support vector machine (SVM) models. At the final stage of the modeling procedure, the data fusion machine learning approach was implemented through using the outcomes of MLP and SVM models to develop two evolutionary models of fusion MLP and hybrid MLP-whale optimization algorithm (MLP-WOA). As a result of conceptual models, the IHACRES-based model better simulated the RR process in comparison to the GR4J, and MISD models. The effect of incorporating meteorological variables into the coupled hydrological process-based and machine learning models was also investigated where precipitation, wind speed, relative humidity, temperature and snow depth were added separately to each hydrological model. It is found that incorporating meteorological variables into the hydrological models increased the accuracy of the models in runoff simulation. Three different learning phases were successfully applied in the current study for improving runoff peak simulation accuracy. This study proved that phase one (only hydrological model) has a big error while phase three (coupling hydrological model by machine learning model) gave a minimum error in runoff estimation in a snow-covered catchment. The IHACRES-based MLP-WOA model with RMSE of 8.49 m3/s improved the performance of the ordinary IHACRES model by a factor of almost 27%. It can be considered as a satisfactory achievement in this study for runoff estimation through applying coupled conceptual-ML hydrological models. Recommended methodology in this study for RR modeling may motivate its application in alternative hydrological problems.

358. Acute and protracted abstinence from methamphetamine bidirectionally changes intrinsic excitability of indirect pathway spiny projection neurons in the dorsomedial striatum.

Sci Rep

2022 Jul 15

Choi S, Du Y, Wokosin DL

359. Validation and promise of a TCR mimic antibody for cancer immunotherapy of hepatocellular carcinoma.

Sci Rep

2022 Jul 15

Liu C(#), Liu H(#), Dasgupta M

360. Relaxation anisotropy of quantitative MRI parameters in biological tissues.

Sci Rep

2022 Jul 15

Hänninen NE, Liimatainen T, Hanni M

361. Ovicidal and repellent activities of several plant essential oils against Periplaneta americana L. and enhanced activities from their combined formulation.

Sci Rep

2022 Jul 15

Soonwera M, Moungthipmalai T, Takawirapat W

362. Discovery of a novel class of benzimidazoles as highly effective agonists of bone morphogenetic protein (BMP) receptor signaling.

Sci Rep

2022 Jul 15

Najafi S, Barasa L, Huang SY

363. Sound localization in web-based 3D environments.

Sci Rep

2022 Jul 15

Rajguru C, Brianza G, Memoli G.

364. Plasmonic hot spots reveal local conformational transitions induced by DNA double-strand breaks.

Sci Rep

2022 Jul 15

Seweryn S, Skirlińska-Nosek K, Wilkosz N

365. Statistical evaluation of proxies for estimating the rainfall erosivity factor.

Sci Rep

2022 Jul 15

Ma X, Zheng M.

366. Transmission history of SARS-CoV-2 in humans and white-tailed deer.

Sci Rep

2022 Jul 15

Willgert K, Didelot X, Surendran-Nair M

367. Accurate image-based CSF volume calculation of the lateral ventricles.

Sci Rep

2022 Jul 15

Yepes-Calderon F, McComb JG.

368. Uric acid and cardiometabolic risk by gender in youth with type 1 diabetes.

Sci Rep

2022 Jul 15

Di Bonito P(#), Rosanio FM(#), Marcovecchio ML

369. Non-monotonous dose response function of the termination of spiral wave chaos.

Sci Rep

2022 Jul 14

Lilienkamp T, Parlitz U, Luther S.

370. A rationally identified panel of microRNAs targets multiple oncogenic pathways to enhance chemotherapeutic effects in glioblastoma models.

Sci Rep

2022 Jul 14

Sadeghipour N, Kumar SU, Massoud TF

371. Lanthanoid-containing polyoxometalate nanocatalysts in the synthesis of bioactive isatin-based compounds.

Sci Rep

2022 Jul 14

Daraie M, Mirzaei M, Bazargan M

372. Multi-omics study identifies novel signatures of DNA/RNA, amino acid, peptide, and lipid metabolism by simulated diabetes on coronary endothelial cells.

Sci Rep

2022 Jul 14

Moreno-Ulloa A, Delgado-De la Herrán HC, Álvarez-Delgado C

373. Spatiotemporal characteristics and influencing factors of grain yield at the county level in Shandong Province, China.

Sci Rep

2022 Jul 14

He H, Ding R, Tian X.

374. Clustering analysis and prognostic signature of lung adenocarcinoma based on the tumor microenvironment.

Sci Rep

2022 Jul 14

Shan Q, Zhang Y, Liang Z.

375. Carbon nanoparticle-entrapped macroporous Mn(3)O(4) microsphere anodes with improved cycling stability for Li-ion batteries.

Sci Rep

2022 Jul 14

Kozawa T, Kitabayashi F, Fukuyama K

376. LRP-1 receptor combines EGFR signalling and eHsp90α autocrine to support constitutive breast cancer cell motility in absence of blood supply.

Sci Rep

2022 Jul 14

Chang C(#), Tang X(#), Mosallaei D

377. Reprocessed magnetorheological elastomers with reduced carbon footprint and their piezoresistive properties.

Sci Rep

2022 Jul 14

Munteanu A, Ronzova A, Kutalkova E

378. The rise of Indian summer monsoon precipitation extremes and its correlation with long-term changes of climate and anthropogenic factors.

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2022 Jul 14

Falga R, Wang C.

379. How well have CMIP3, CMIP5 and CMIP6 future climate projections portrayed the recently observed warming.

Sci Rep

2022 Jul 14

Carvalho D, Rafael S, Monteiro A

380. Cabin1 domain-containing gene picd-1 interacts with pry-1/Axin to regulate multiple processes in Caenorhabditis elegans.

Sci Rep

2022 Jul 14

Mallick A, Taylor SKB, Mehta S

381. Network-medicine framework for studying disease trajectories in U.S. veterans.

Sci Rep

2022 Jul 14

do Valle IF, Ferolito B, Gerlovin H

382. Circ_0000181 regulates miR-667-5p/NLRC4 axis to promote pyroptosis progression in diabetic nephropathy.

Sci Rep

2022 Jul 14

Li Y, Yu W, Xiong H

383. Nutritional support for successful weaning in patients undergoing prolonged mechanical ventilation.

Sci Rep

2022 Jul 14

Lo SC, Ma KS, Li YR

384. Genomic palaeoparasitology traced the occurrence of Taenia asiatica in ancient Iran (Sassanid Empire, 2th cent. CE-6th cent. CE).

Sci Rep

2022 Jul 14

Askari Z, Ruehli F, Bouwman A

385. Chromosomal phase improves aneuploidy detection in non-invasive prenatal testing at low fetal DNA fractions.

Sci Rep

2022 Jul 14

Genovese G, Mello CJ, Loh PR

386. Genital microbiota of women using a 90 day tenofovir or tenofovir and levonorgestrel intravaginal ring in a placebo controlled randomized safety trial in Kenya.

Sci Rep

2022 Jul 14

Dabee S, Mugo N, Mudhune V

387. Proteomic profiling of plasma exosomes from patients with B-cell acute lymphoblastic leukemia.

Sci Rep

2022 Jul 13

Zhu S, Xing C, Li R

388. Inducing Dzyaloshinskii-Moriya interaction in symmetrical multilayers using post annealing.

Sci Rep

2022 Jul 13

Ahmadi K, Mahfouzi F, Jamilpanah L

389. Regulation of extracellular matrix components by AmrZ is mediated by c-di-GMP in Pseudomonas ogarae F113.

Sci Rep

2022 Jul 13

Blanco-Romero E, Garrido-Sanz D, Durán D

390. Rapid, in-field deployable, avian influenza virus haemagglutinin characterisation tool using MinION technology.

Sci Rep

2022 Jul 13

de Vries EM, Cogan NOI, Gubala AJ

391. Mortality rate of high cardiovascular risk patients with mild cognitive impairment.

Sci Rep

2022 Jul 13

Yaneva-Sirakova T, Traykov L.

People with mild cognitive impairment (MCI) may be at higher risk of death than normal aging ones. On the other hand, patients with cardiovascular risk factors are also with higher risk of death. It may be logical to question then if the combination of MCI and cardio-vascular risk factors (in most cases arterial hypertension) can lead to higher mortality rate than expected both for high cardio-vascular risk patients and for the general population. This hypothesis is important in the light of effective early screening and prophylaxis. The general death rate of patients with very high-cardio-vascular-risk was compared in the subgroups of normal cognition and MCI. We used MMSE and MoCA (reassessment 6 months apart), Geriatric Depression scale and 4-point version of the scale for evaluating the performance in instrumental activities of daily living (4-IADL) in 249 patients. The patients also had laboratory testing, ambulatory blood pressure monitoring, ECG and echocardiography. The general mortality rate of this very high cardio-vascular risk group was assessed 8-10 years afterwards and also compared to the general national death rate published for the corresponding period from the National Social Security Institute of Bulgaria. We registered significantly higher general death rate in patients with MCI and very high cardio-vascular risk as compared to the group without MCI. The logistic regression analysis attributed approximately 14.6% of the mortality rate in this high-risk group to MCI. The major cardio-vascular risk factor was arterial hypertension-with 63.85% of the patients with home blood pressure values not in the target range at the initial cognitive screening. During the neuropsychological reevaluation 56.43% were with poor control despite the multidrug antihypertensive regimen. It is known that MCI is correlated with cardiovascular risk factors with the leading role of arterial hypertension. We found that the combination of MCI and arterial hypertension can lead to higher mortality rate than in the general aging population. This has important clinical implications for the everyday practice.

392. The Campsis-Icterus association as a model system for avian nectar-robbery studies.

Sci Rep

2022 Jul 13

Graves GR.

393. Maternal childbirth experience and time in labor: a population-based cohort study.

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2022 Jul 13

Carlhäll S, Nelson M, Svenvik M

394. Improved inpatient deterioration detection in general wards by using time-series vital signs.

Sci Rep

2022 Jul 13

Su CF, Chiu SI, Jang JR

395. The impact of implantation site on procedure success in patients with unresolved facial palsy treated with upper-eyelid gold weight loading.

Sci Rep

2022 Jul 13

Nowak-Gospodarowicz I, Koktysz R, Rękas M.

396. The influence and acting pattern of China's national carbon emission trading scheme on regional ecologicalization efficiency of industry.

Sci Rep

2022 Jul 13

Fu C, Huang Y, Zheng Y

397. Cross-sectional computed tomography assessment of exophthalmos in comparison to clinical measurement via Hertel exophthalmometry.

Sci Rep

2022 Jul 13

Klingenstein A, Samel C, Garip-Kübler A

398. Low anti-Müllerian hormone levels are associated with an increased risk of incident early-onset vasomotor symptoms among premenopausal women.

Sci Rep

2022 Jul 13

NamGoung S(#), Chang Y(#), Kim Y

399. Use of exogenous fibrolytic enzymes and probiotic in finely ground starters to improve calf performance.

Sci Rep

2022 Jul 13

Khademi AR, Hashemzadeh F, Khorvash M

400. Varus stress MRI in the refined assessment of the posterolateral corner of the knee joint.

Sci Rep

2022 Jul 13

Ciba M, Winkelmeyer EM, Schock J

401. A first-principles-based high fidelity, high throughput approach for the design of high entropy alloys.

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2022 Jul 13

Sorkin V, Yu ZG, Chen S

402. Mapping and determinants of consumption of egg and/or flesh foods and zero vegetables or fruits among young children in SSA.

Sci Rep

2022 Jul 13

Hailu BA, Geremew BM, Liverani S

403. Experimental study on the influence of mental fatigue on risk decision-making of miners.

Sci Rep

2022 Jul 13

Jia A, Guo X, Tian S.

404. Exploratory analysis using machine learning of predictive factors for falls in type 2 diabetes.

Sci Rep

2022 Jul 13

Suzuki Y, Suzuki H, Ishikawa T

405. Ultrafast-UV laser integrating cavity device for inactivation of SARS-CoV-2 and other viruses.

Sci Rep

2022 Jul 13

Ambardar S(#), Howell MC Jr(#), Mayilsamy K(#)

406. Spatiotemporal expression of HMGB2 regulates cell proliferation and hepatocyte size during liver regeneration.

Sci Rep

2022 Jul 13

Yano K, Choijookhuu N, Ikenoue M

407. Transgenic overexpression of microRNA-30d in pancreatic beta-cells progressively regulates beta-cell function and identity.

Sci Rep

2022 Jul 13

Mao Y, Schoenborn J, Wang Z

408. Pancreatic adenocarcinoma associated immune-gene signature as a novo risk factor for clinical prognosis prediction in hepatocellular carcinoma.

Sci Rep

2022 Jul 13

Dai L(#), Mugaanyi J(#), Cai X

409. A portable negative pressure unit reduces bone cement fumes in a simulated operating room.

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2022 Jul 13

Carroll GT, Kirschman DL.

410. Deficiency of protocadherin 9 leads to reduction in positive emotional behaviour.

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2022 Jul 13

Uemura M, Furuse T, Yamada I

411. Phase synchronization of chlorophyll and total phosphorus oscillations as an indicator of the transformation of a lake ecosystem.

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2022 Jul 13

Rusakov AV, Adamovich BV, Nurieva NI

412. Aerobic capacity of professional soccer players before and after COVID-19 infection.

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2022 Jul 13

Parpa K, Michaelides M.

413. Preoperative prediction of the need for arterial and central venous catheterization using machine learning techniques.

Sci Rep

2022 Jul 13

Suh J, Lee SW.

414. Moving closer to experimental level materials property prediction using AI.

Sci Rep

2022 Jul 13

Jha D(#), Gupta V(#), Liao WK

415. Short-sighted decision-making by those not vaccinated against COVID-19.

Sci Rep

2022 Jul 13

Halilova JG, Fynes-Clinton S, Green L

416. Physics of emergence beyond Berezinskii-Kosterlitz-Thouless transition for interacting topological quantum matter.

Sci Rep

2022 Jul 13

Kumar RR, Sarkar S.

417. SARS-CoV-2 potential drugs, drug targets, and biomarkers: a viral-host interaction network-based analysis.

Sci Rep

2022 Jul 13

Samy A(#), Maher MA(#), Abdelsalam NA

418. Case study of the convergent evolution in the color patterns in the freshwater bivalves.

Sci Rep

2022 Jul 13

Asato K, Nakayama K, Imai T.

419. The evolution of neurosensation provides opportunities and constraints for phenotypic plasticity.

Sci Rep

2022 Jul 13

Chen EY, Adams DK.

420. Reconstructing firm-level interactions in the Dutch input-output network from production constraints.

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2022 Jul 13

Ialongo LN, de Valk C, Marchese E

421. Predictive factors for massive hemorrhage in women with retained products of conception: a prospective study.

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2022 Jul 13

Sonehara R, Nakamura T, Iwase A

422. Characterization of mitochondrial dysfunction due to laser damage by 2-photon FLIM microscopy.

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2022 Jul 13

Alam SR, Wallrabe H, Christopher KG

423. Electrochemical investigation of carbon paper/ZnO nanocomposite electrodes for capacitive anion capturing.

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2022 Jul 12

Chalangar E, Björk EM, Pettersson H.

424. Analysis of entropy production in a bi-convective magnetized and radiative hybrid nanofluid flow using temperature-sensitive base fluid (water) properties.

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2022 Jul 12

Barman T, Roy S, Chamkha AJ.

The heat transport characteristics, flow features, and entropy-production of bi-convection buoyancy induced, radiation-assisted hydro-magnetic hybrid nanofluid flow with thermal sink/source effects are inspected in this study. The physical characteristics of hybrid nanofluids (water-hosted) are inherited from the base liquid (water) and none has considered the physical characteristics of base liquid (water) in the study of temperature-sensorial hybrid nanofluid investigations, though the water physical characteristics are not constants in temperature variations. So, the temperature-sensorial attributes of base liquid (water) are taken into account for this hybrid nanofluid ([Formula: see text]) flow analysis. The mathematical forms of the flow configuration (i.e., the set of coupled, nonlinear PDE form of governing equations) are solved by utilizing the subsequent tasks: (i) congenial transformation; (ii) quasilinearization; (iii) methods of finite differences to form block matrix system, and (iv) Varga's iterative algorithm. The preciseness of the whole numerical procedure is ensured by restricting the computation to follow strict convergence conditions. Finally, the numerically extracted results representing the impacts of various salient parameters on different profiles ([Formula: see text]), gradients, and entropy production are exhibited in physical figures for better perception. A few noticeable results are highlighted as: velocity graph shows contrast behaviour under assisting and opposing buoyancy; temperature ([Formula: see text]) is dropping for heightening heat source ([Formula: see text]) surface friction remarkably declines with the outlying magnetic field ([Formula: see text]); thermal transport confronts drastic abatement under radiation ([Formula: see text]), and [Formula: see text]; the characteristics Reynolds and Brinkman numbers promote entropy. Furthermore, the bounding surface acts as a strong source of [Formula: see text]-production. Summarizations are listed at the end to quantify percentage variations.

425. The conserved C-terminal residues of FAM83H are required for the recruitment of casein kinase 1 to the keratin cytoskeleton.

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2022 Jul 12

Kuga T, Inoue N, Sometani K

426. Data-driven discovery of the governing equations of dynamical systems via moving horizon optimization.

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2022 Jul 12

Lejarza F, Baldea M.

427. A single session of exercise reduces blood pressure reactivity to stress: a systematic review and meta-analysis.

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2022 Jul 12

Mariano IM, Amaral AL, Ribeiro PAB

428. On the mechanism of marine fouling-prevention performance of oil-containing silicone elastomers.

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2022 Jul 12

Kolle S, Ahanotu O, Meeks A

429. Structural controls on bedrock weathering in crystalline basement terranes and its implications on groundwater resources.

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2022 Jul 12

Pradhan RM, Singh A, Ojha AK

430. O-terminated interface for thickness-insensitive transport properties of aluminum oxide Josephson junctions.

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2022 Jul 12

Shan Z, Gou X, Sun H

431. Anti-proliferative and immunomodulatory potencies of cinnamon oil on Ehrlich ascites carcinoma bearing mice.

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2022 Jul 12

Morsi DS, El-Nabi SH, Elmaghraby MA

432. Treadmill locomotion in the American alligator (Alligator mississippiensis) produces dynamic changes in intracranial cerebrospinal fluid pressure.

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2022 Jul 12

Young BA, Cramberg MJ.

433. Prevalence of fatigue at one-year follow-up from the Gothenburg recovery and rehabilitation after COVID-19 and intensive care unit study.

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2022 Jul 12

Hussain N, Samuelsson CM, Drummond A

434. Mycobacterium intracellulare induces a Th17 immune response via M1-like macrophage polarization in canine peripheral blood mononuclear cells.

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2022 Jul 12

Kim S, Hyun YS, Park HT

435. Electrochemical behavior of 2205 duplex stainless steel in simulated solution containing high concentration Cl(-) and saturated CO(2) at different temperatures.

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2022 Jul 12

Li Y, Zhu S, Xian J

436. Effects of yoga on cardiometabolic risks and fetomaternal outcomes are associated with serum nitric oxide in gestational hypertension: a randomized control trial.

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2022 Jul 12

Karthiga K, Pal GK, Dasari P

Gestational hypertension (GH) is associated with adverse cardiometabolic and pregnancy outcomes. Though yoga is known to be beneficial in pregnancy, the effects of yoga rendered for twenty weeks starting from 16th week of gestation in pregnant women having risk of GH on the incidence of hypertension, cardiometabolic risks and fetomaternal outcomes have not been studied. A randomized control trial was conducted on 234 pregnant women having risk of GH receiving standard antenatal care (Control group, n = 113), and receiving standard care + yoga (Study group, n = 121). Interventions were given for twenty weeks starting at 16th week of gestation. Baroreflex sensitivity (BRS), heart rate variability (HRV), insulin resistance, lipid-risk factors, and markers of inflammation, oxidative stress and vascular endothelial dysfunction (VED) were assessed before and after intervention. Incidence of new-onset hypertension, level of cardiometabolic risks at 36th week, and fetomaternal-neonatal outcomes in the perinatal period, were noted. The link of hypertension, pregnancy outcomes and cardiometabolic risks with nitric oxide (NO), the marker of VED was assessed by analysis of covariance, Pearson's correlations, and multilinear and logistic regressions. In study group, 6.61% women developed hypertension compared to 38.1% in the control group following 20-week intervention and there was significant decrease in risk of developing GH (RR, 2.65; CI 1.42-4.95). There was less-painful delivery, decreased duration of labor, increased neonatal birthweight and Apgar score in study group. Increase in total power of HRV (β = 0.187, p = 0.024), BRS (β = 0.305, p < 0.001), and decrease in interleukin-6 (β = - 0.194, p = 0.022) had significant association with increased NO. Twenty weeks of practice of yoga during pregnancy decreases the incidence of hypertension, improves fetomaternal outcomes, and reduces cardiometabolic risks in pregnant women having risk of GH. Decreased blood pressure, increased HRV, BRS and birth weight and decreased inflammation were associated with improved endothelial function. Trial registration: Clinical Trials Registry of India (CTRI), registration number: CTRI/2017/11/010608, on 23.11.2017.

437. Reduced cerebral vascular fractal dimension among asymptomatic individuals as a potential biomarker for cerebral small vessel disease.

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2022 Jul 11

Aminuddin N, Achuthan A, Ruhaiyem NIR

438. Flow field characteristics and experimental research on inner-jet electrochemical face grinding of SUS420J2 stainless steel.

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2022 Jul 11

Wang F, He Y, Wu X

439. A human IgM enriched immunoglobulin preparation, Pentaglobin, reverses autoimmune diabetes without immune suppression in NOD mice.

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2022 Jul 11

Wilson CS, Hoopes EM, Falk AC

440. Risk trajectories of complications in over one thousand newly diagnosed individuals with type 2 diabetes.

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2022 Jul 11

Höskuldsdóttir G, Franzén S, Eeg-Olofsson K

441. Multimorbidity and multi-disability among the elderly in residential care in India: the Hyderabad Ocular Morbidity in Elderly Study (HOMES).

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2022 Jul 11

Marmamula S, Kumbham TR, Shidhaye R

442. Thermodynamically-guided machine learning modelling for predicting the glass-forming ability of bulk metallic glasses.

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2022 Jul 11

Ghorbani A, Askari A, Malekan M

443. The effectiveness of 20 μg hepatitis B vaccine used for the prevention of HBV vertical transmission.

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2022 Jul 11

Yonghao G(#), Yanping C(#), Qiaohua D

444. The COVID-19 pandemic in Brazilian pregnant and postpartum women: results from the REBRACO prospective cohort study.

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2022 Jul 11

Souza RT, Cecatti JG, Pacagnella RC

445. Retinal drusen counts are increased in inflammatory bowel disease, and with longer disease duration, more complications and associated IgA glomerulonephritis.

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2022 Jul 11

Nicklason E(#), Ham Y(#), Ng D

446. Stockwell transform and semi-supervised feature selection from deep features for classification of BCI signals.

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2022 Jul 11

Salimpour S, Kalbkhani H, Seyyedi S

447. Sulindac acetohydrazide derivative attenuates against cisplatin induced organ damage by modulation of antioxidant and inflammatory signaling pathways.

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2022 Jul 11

Razak S(#), Afsar T(#), Bibi N(#)

This study aimed to explore the mechanisms of action of a sulindac acetohydrazide derivative, N'-(4-dimethylaminobenzylidene)-2-1-(4-(methylsulfinyl) benzylidene)-5-fluoro-2-methyl-1H-inden-3-yl) acetohydrazide, against anticancer drug cisplatin induced organ damage. Using a rodent model, various markers of organ function and signaling pathways were examined and validated by molecular docking studies. The study involves five groups of animals: control, DMSO, CDDP, CDDP + DMFM, and DMFM. Biochemical enzyme activity, histopathology, tissue antioxidant, and oxidative stress markers were examined. RT-PCR and western blot analyses were conducted for the expression of inducible cyclooxygenase enzyme (COX-2), nuclear factor kappa beta (NF-κB), p65, IL-1, TNF-α, and inducible nitric oxide synthase (iNOS). Flow cytometry analysis of CD4 + TNF-α, CD4 + COX-2, and CD4 + STAT-3 cells in whole blood was performed. Structural and dynamic behavior of DMFM upon binding with receptor molecule molecular docking and dynamic simulations were performed using bioinformatics tools and software. Treatment with DMFM reversed cisplatin-induced malondialdehyde (MDA) and nitric oxide (NO) induction, whereas the activity of glutathione peroxidase (GPx), and superoxide dismutase (SOD) in the kidney, heart, liver, and brain tissues were increased. DMFM administration normalized plasma levels of biochemical enzymes. We observed a marked decline in CD4 + STAT3, TNF-α, and COX2 cell populations in whole blood after treatment with DMFM. DMFM downregulated the expression factors related to inflammation at the mRNA and protein levels, i.e., IL-1, TNF-α, iNOS, NF-κB, STAT-3, and COX-2. Dynamic simulations and in silico docking data supports the experimental findings. Our experimental and in silico results illustrated that DMFM may affect protective action against cisplatin-induced brain, heart, liver, and kidney damage via reduction of inflammation and ROS.

448. Sea lions could use multilateration localization for object tracking as tested with bio-inspired whisker arrays.

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2022 Jul 11

Glick R, Muthuramalingam M, Brücker C.

449. Non-political anger shifts political preferences towards stronger leaders.

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2022 Jul 11

Ambroziak KB, Safra L, Tsakiris M.

450. An accurate alignment-free protein sequence comparator based on physicochemical properties of amino acids.

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2022 Jul 1

Akbari Rokn Abadi S, Abdosalehi AS, Pouyamehr F

451. Familiarity modulates both intra- and interspecific yawn contagion in red-capped mangabeys.

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2022 Jul 1

Pedruzzi L, Aychet J, Le Vern L

452. Diagnostic accuracy of quick SOFA score and inflammatory biomarkers for predicting community-onset bacteremia.

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2022 Jul 1

Matono T, Yoshida M, Koga H

453. RF-CNN-F: random forest with convolutional neural network features for coronary artery disease diagnosis based on cardiac magnetic resonance.

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2022 Jul 1

Khozeimeh F, Sharifrazi D, Izadi NH

454. Postoperative recovery patterns following discectomy surgery in patients with lumbar radiculopathy.

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2022 Jul 1

Wang S, Hebert JJ, Abraham E

455. Leaf bacterial microbiota response to flooding is controlled by plant phenology in wheat (Triticum aestivum L.).

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2022 Jul 1

Francioli D, Cid G, Hajirezaei MR

456. Sensorimotor performance after high-definition transcranial direct current stimulation over the primary somatosensory or motor cortices in men versus women.

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2022 Jul 1

Swissa Y, Hacohen S, Friedman J

457. Characteristics and mortality of 561,379 hospitalized COVID-19 patients in Germany until December 2021 based on real-life data.

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2022 Jul 1

Kloka JA(#), Blum LV(#), Old O

458. A novel hamster model of SARS-CoV-2 respiratory infection using a pseudotyped virus.

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2022 Jul 1

Yamada H, Sasaki SI, Tani H

459. Biophysical evaluation of treating adipose tissue-derived stem cells using non-thermal atmospheric pressure plasma.

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2022 Jul 1

Shojaei E, Zare S, Shirkavand A

460. J-Matrix time propagation of atomic hydrogen in attosecond fields.

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2022 Jul 1

Gersbacher R, Broad JT.

461. Interactions of boron nitride nanosheet with amino acids of differential polarity.

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2022 Jul 1

Najafi F, Farzad F, Pasban S.

462. Computational assessment of groundwater salinity distribution within coastal multi-aquifers of Bangladesh.

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2022 Jul 1

Jamei M, Karbasi M, Malik A

The rising salinity trend in the country's coastal groundwater has reached an alarming rate due to unplanned use of groundwater in agriculture and seawater seeping into the underground due to sea-level rise caused by global warming. Therefore, assessing salinity is crucial for the status of safe groundwater in coastal aquifers. In this research, a rigorous hybrid neurocomputing approach comprised of an Adaptive Neuro-Fuzzy Inference System (ANFIS) hybridized with a new meta-heuristic optimization algorithm, namely Aquila optimization (AO) and the Boruta-Random forest feature selection (FS) was developed for estimating the salinity of multi-aquifers in coastal regions of Bangladesh. In this regard, 539 data samples, including ten water quality indices, were collected to provide the predictive model. Moreover, the individual ANFIS, Slime Mould Algorithm (SMA), and Ant Colony Optimization for Continuous Domains (ACOR) coupled with ANFIS (i.e., ANFIS-SMA and ANFIS-ACOR) and LASSO regression (Lasso-Reg) schemes were examined to compare with the primary model. Several goodness-of-fit indices, such as correlation coefficient (R), the root mean squared error (RMSE), and Kling-Gupta efficiency (KGE) were used to validate the robustness of the predictive models. Here, the Boruta-Random Forest (B-RF), as a new robust tree-based FS, was adopted to identify the most significant candidate inputs and effective input combinations to reduce the computational cost and time of the modeling. The outcomes of four selected input combinations ascertained that the ANFIS-OA regarding the best accuracy in terms of (R = 0.9450, RMSE = 1.1253 ppm, and KGE = 0.9146) outperformed the ANFIS-SMA (R = 0.9406, RMSE = 1.1534 ppm, and KGE = 0.8793), ANFIS-ACOR (R = 0.9402, RMSE = 1.1388 ppm, and KGE = 0.8653), Lasso-Reg (R = 0.9358), and ANFIS (R = 0.9306) models. Besides, the first candidate input combination (C1) by three inputs, including Cl- (mg/l), Mg2+ (mg/l), Na+ (mg/l), yielded the best accuracy among all alternatives, implying the role importance of (B-RF) feature selection. Finally, the spatial salinity distribution assessment in the study area ascertained the high predictability potential of the ANFIS-OA hybrid with B-RF feature selection compared to other paradigms. The most important novelty of this research is using a robust framework comprised of the non-linear data filtering technique and a new hybrid neuro-computing approach, which can be considered as a reliable tool to assess water salinity in coastal aquifers.

463. Interleukin 7 inhibit autophagy via P53 regulated AMPK/mTOR signaling pathway in non-small cell lung cancer.

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2022 Jul 1

Zhu Y, Jiang X, Ding Z

464. Propensity-score matched analysis to evaluate efficacy of endoscopic submucosal dissection for superficial esophageal cancer in gastrectomized patients.

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2022 Jul 1

Hamada Y, Tanaka K, Katsurahara M

465. Optimization of industrial (3000 L) production of Bacillus subtilis CW-S and its novel application for minituber and industrial-grade potato cultivation.

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2022 Jul 1

Abuhena M(#), Al-Rashid J(#), Azim MF(#)

466. The role of serum Wisteria floribunda agglutinin-positive Mac-2 binding protein in the assessment of fibrosis in children with chronic hepatitis C.

Sci Rep

2022 Jul 1

Tajiri H, Suzuki M, Bessho K

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Newmer生物