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期刊文献 > Sci Rep期刊选择月份

Sci Rep

2022 Apr 9

Banakar SN, PrasannaKumar MK, Mahesh HB

2. Influence of Chlorella vulgaris on growth, digestibility and gut morphology and microbiota of weaned piglet.

Sci Rep

2022 Apr 9

Martins CF, Trevisi P, Coelho DF

3. Decoding herbal materials of TCM preparations with the multi-barcode sequencing approach.

Sci Rep

2022 Apr 9

Yao Q(#), Zhu X(#), Han M

4. A glibenclamide-sensitive TRPM4-mediated component of CA1 excitatory postsynaptic potentials appears in experimental autoimmune encephalomyelitis.

Sci Rep

2022 Apr 9

Fearey BC, Binkle L, Mensching D

5. Experimental evidence challenges the presumed defensive function of a "slow toxin" in cycads.

Sci Rep

2022 Apr 9

Whitaker MRL, Gilliéron F, Skirgaila C

6. Facile fabrication of ternary MWCNTs/ZnO/Chitosan nanocomposite for enhanced photocatalytic degradation of methylene blue and antibacterial activity.

Sci Rep

2022 Apr 8

Malekkiani M, Heshmati Jannat Magham A, Ravari F

7. Fireworks ocular injury in Saudi children: profile and management outcomes.

Sci Rep

2022 Apr 8

AlGhadeer H, Khandekar R.

8. Analytic solution for double optical metasurface beam scanners.

Sci Rep

2022 Apr 8

Wang J, Ge Y, Chen ZD

9. Impact of experience on visual behavior and driving performance of high-speed train drivers.

Sci Rep

2022 Apr 8

Du Y, Zhi JY, He SJ.

10. Endoscopic ultrasound-guided side-fenestrated needle biopsy sampling is sensitive for pancreatic neuroendocrine tumors but inadequate for tumor grading: a prospective study.

Sci Rep

2022 Apr 8

Appelstrand A, Bergstedt F, Elf AK

11. Indigenous cellulolytic aerobic and facultative anaerobic bacterial community enhanced the composting of rice straw and chicken manure with biochar addition.

Sci Rep

2022 Apr 8

Zainudin MHM, Singam JT, Sazili AQ

12. Development and validation of a predictive nomogram for preoperative deep vein thrombosis (DVT) in isolated calcaneal fracture.

Sci Rep

2022 Apr 8

Cheng X(#), Lei X(#), Wu H

13. Processing of high temperature alumina/aluminum titanate ceramic composites from clean sources.

Sci Rep

2022 Apr 8

Besisa NHA, Besisa DHA, Ewais EMM.

Producing new technological materials with high performance from clean sources has become a global requirement. Alumina/aluminum titanate (Al2O3/Al2TiO5) composites are high-temperature portentous materials used in various advanced applications. In this work, different Al2O3/Al2TiO5 composites were obtained with high thermal and mechanical properties for high-temperature applications by a low-cost process. The targeted composites were produced from calcined alumina and, rutile ore extracted from the Egyptian black sands by pressureless sintering at a temperature of 1650 °C/2 h. Rutile was added to alumina with a different content (0-40 wt%) to promote its sinterability and thermo-mechanical response. Evaluation of the produced composites in terms of phase composition, densification, microstructural features, mechanical and thermal properties was investigated. The results indicated that the addition of small amounts of rutile (10 and 20 wt%) succeeded in forming a stable Al2O3/Al2TiO5 composite structure. However, higher content of rutile led to the formation of Al2TiO5 rich matrix composites. Moreover, highly dense composites with harmonic microstructure and enhanced mechanical strength were attained by increasing the rutile content. The composite with only 10 wt% rutile addition gave the highest density of 3.6 g/cm3 and the highest cold crushing strength and modulus of rupture values of 488.73 MPa and 106.19 MPa, respectively. Notably, the addition of rutile has a substantial effect on promoting the thermal properties and thermal stability of the obtained composites up to a high temperature of 1400 °C. The present study shows that addition of rutile ore to alumina is one economical way of improving the densification and thermal expansion of Al2O3 for high temperature applications. Using a clean source such as rutile ore that contains some thermal stabilizers as Fe2O3, Al2O3, SiO2, ZrO2, and MgO instead of pure TiO2 has played a noticeable role in improving the reaction sintering and resulting in a highly qualified material. Thus, sintered Al2O3/Al2TiO5 composites can be considered as a promising high-temperature material for advanced applications.

14. Hysteretic hERG channel gating current recorded at physiological temperature.

Sci Rep

2022 Apr 8

Jones DK.

15. Ultrasound and nerve stimulator guidance lumbar transforaminal epidural block for the treatment of patients with lumbosacral radicular pain.

Sci Rep

2022 Apr 8

Emami SA, Sanatkar M, Espahbodi E

16. Anticancer, antioxidant, antiviral and antimicrobial activities of Kei Apple (Dovyalis caffra) fruit.

Sci Rep

2022 Apr 8

Qanash H, Yahya R, Bakri MM

Secondary plant metabolites remain one of the key sources of therapeutic agents despite the development of new approaches for the discovery of medicinal drugs. In the current study, chemical analysis, and biological activities of Kei apple (Dovyalis caffra) methanolic extract were evaluated. Chemical analysis was performed using HPLC and GC-MS. Antiviral and anticancer effect were assessed using the crystal violet technique and activity against human liver cells (HepG2), respectively. Antibacterial activity was tested with the disc diffusion method. The obtained results showed that chlorogenic acid (2107.96 ± 0.07 µg/g), catechin (168 ± 0.58 µg/g), and gallic acid (15.66 ± 0.02 µg/g) were the main bioactive compounds identified by HPLC techniques. While, compounds containing furan moieties, as well as levoglucosenone, isochiapin B, dotriacontane, 7-nonynoic acid and tert-hexadecanethiol, with different biological activities were identified by GC-MS. Additionally, inhibition of 2,2-diphenyl-1-picryl-hydrazyl-hydrate (DPPH) scavenging was 79.25% at 2000 µg/mL, indicating its antioxidant activity with IC50 of 728.20 ± 1.04 µg/mL. The tested extract exhibited potential anticancer activity (58.90% toxicity) against HepG2 cells at 1000 µg/mL. Potential bacterial inhibition was observed mainly against Escherichia coli and Proteus vulgaris, followed by Staphylococcus aureus and Bacillus subtilis with a diameter of growth inhibition ranging from 13 to 24 mm. While weak activities were recorded for fungi Candida albicans (10 mm). The extract showed mild antiviral activity against human coronavirus 229E with a selective index (SI) of 10.4, but not against human H3N2 (SI of 0.67). The molecular docking study's energy ratings were in good promise with the experiment documents of antibacterial and antiviral activities. The findings suggest that D. caffra juice extract is a potential candidate for further experiments to assess its use as potential alternative therapeutic agent.

17. Prenatal opioid-exposed infant extracellular miRNA signature obtained at birth predicts severity of neonatal opioid withdrawal syndrome.

Sci Rep

2022 Apr 8

Mahnke AH, Roberts MH, Leeman L

18. Relationships between species richness and ecosystem services in Amazonian forests strongly influenced by biogeographical strata and forest types.

Sci Rep

2022 Apr 8

Steur G, Ter Steege H, Verburg RW

19. Detection and discrimination of neutron capture events for NCEPT dose quantification.

Sci Rep

2022 Apr 7

Chacon A, Kielly M, Rutherford H

Neutron Capture Enhanced Particle Therapy (NCEPT) boosts the effectiveness of particle therapy by capturing thermal neutrons produced by beam-target nuclear interactions in and around the treatment site, using tumour-specific [Formula: see text]B or [Formula: see text]Gd-based neutron capture agents. Neutron captures release high-LET secondary particles together with gamma photons with energies of 478 keV or one of several energies up to 7.94 MeV, for [Formula: see text]B and [Formula: see text]Gd, respectively. A key requirement for NCEPT's translation is the development of in vivo dosimetry techniques which can measure both the direct ion dose and the dose due to neutron capture. In this work, we report signatures which can be used to discriminate between photons resulting from neutron capture and those originating from other processes. A Geant4 Monte Carlo simulation study into timing and energy thresholds for discrimination of prompt gamma photons resulting from thermal neutron capture during NCEPT was conducted. Three simulated [Formula: see text] mm[Formula: see text] cubic PMMA targets were irradiated by [Formula: see text]He or [Formula: see text]C ion beams with a spread out Bragg peak (SOBP) depth range of 60 mm; one target is homogeneous while the others include [Formula: see text] mm[Formula: see text] neutron capture inserts (NCIs) of pure [Formula: see text]B or [Formula: see text]Gd located at the distal edge of the SOBP. The arrival times of photons and neutrons entering a simulated [Formula: see text] mm[Formula: see text] ideal detector were recorded. A temporal mask of 50-60 ns was found to be optimal for maximising the discrimination of the photons resulting from the neutron capture by boron and gadolinium. A range of candidate detector and thermal neutron shielding materials were simulated, and detections meeting the proposed acceptance criteria (i.e. falling within the target energy window and arriving 60 ns post beam-off) were classified as true or false positives, depending on their origin. The ratio of true/false positives ([Formula: see text]) was calculated; for targets with [Formula: see text]B and [Formula: see text]Gd NCIs, the detector materials which resulted in the highest [Formula: see text] were cadmium-shielded CdTe and boron-shielded LSO, respectively. The optimal irradiation period for both carbon and helium ions was 1 µs for the [Formula: see text]B NCI and 1 ms for the [Formula: see text]Gd NCI.

20. Behavioral intentions of rural farmers to recycle human excreta in agriculture.

Sci Rep

2022 Apr 7

Gwara S, Wale E, Odindo A.

21. Executive failure hypothesis explains the trait-level association between motivation and mind wandering.

Sci Rep

2022 Apr 7

Kawagoe T.

22. Evaluation of a new transcutaneous bilirubinometer in newborn infants.

Sci Rep

2022 Apr 7

Norman M, Aytug H, Celebi HB.

23. High intestinal parasite infection detected in children from Región Autónoma Atlántico Norte (R.A.A.N.) of Nicaragua.

Sci Rep

2022 Apr 7

Muñoz-Antoli C, Pérez P, Pavón A

24. Affective response to physical activity as a deep phenotype in a non-randomized pilot study.

Sci Rep

2022 Apr 7

Lee HH, McGeary JE, Dunsiger S

Large-scale genomic studies are beginning to identify genetic predictors of physical activity (PA). For those genetically predisposed to engage in low PA, a behavioral intervention may target a malleable factor that mediates genetic predisposition to low PA (i.e., intermediate phenotype) to mitigate the genetic influences. In a non-randomized exercise promotion pilot study, we test the feasibility of examining affective response to PA (how one feels during PA) as an intermediate phenotype between genetic variation and PA adherence. We hypothesized that three single nucleotide polymorphisms (SNPs; rs8044769 and rs3751812 in FTO; rs6265 in BDNF), identified from a prior systematic review, would be predictive of affective response to PA, and that affective response to PA would mediate the SNP-PA link. Forty five healthy, low-active adults received a 12-week print-based PA promotion program. Baseline affective response to PA was assessed using the Feeling Scale, a single-item measure of affective valence. Moderate to vigorous PA (MVPA) was assessed using accelerometers pre- and post-intervention. We examined the three SNPs in a weighted genetic score. Age, sex, body mass index, race, and neighborhood walkability were potential covariates. Affective response to PA and MVPA at follow-up (minutes/day over 4-7 days) were regressed on variation in SNPs, controlling for covariates. One unit increase in genetic score was associated with a 0.14 higher mean Feeling Scale, though was not statistically significant (p = 0.13). Among individual SNPs, having an additional FTO rs8044769 C allele was associated with a mean Feeling Scale score of 0.53 units higher (p = 0.015), which was statistically significant after applying the corrected p-value of 0.016. The genetic score or individual SNPs were not predictive of MVPA 12 weeks later, thereby mediation analyses were not performed. The preliminary findings demonstrate the promise of the intermediate phenotype approach.

25. Optimization of the nutritional constituents for ergosterol peroxide production by Paecilomyces cicadae based on the uniform design and mathematical model.

Sci Rep

2022 Apr 7

Fenhui S, He L, Qian J

26. Individual treatment effect estimation in the presence of unobserved confounding using proxies: a cohort study in stage III non-small cell lung cancer.

Sci Rep

2022 Apr 7

van Amsterdam WAC, Verhoeff JJC, Harlianto NI

27. Quantum spinning photonic circulator.

Sci Rep

2022 Apr 7

Jing YW.

28. Ultra-sensitive detection of pyridine in water using zinc porphyrin incorporated in a transparent hydrophobic film.

Sci Rep

2022 Apr 6

Sasai R, Aoyama YH, Fujimura T.

29. Preoperative quadriceps muscle strength deficit severity predicts knee function one year after anterior cruciate ligament reconstruction.

Sci Rep

2022 Apr 6

Kim DK, Park G, Wang JH

30. The impact of Tamarix invasion on the soil physicochemical properties.

Sci Rep

2022 Apr 6

Araya T, Mlahlwa AV, Elbasit MAMA

The exotic Tamarix species, T. ramosissima and T. chinensis, were introduced into South Africa in the early 1900s reportedly either for ornamental or soil wind erosion control purposes in the mines. They are, however, currently invading several riparian ecosystems in the country and threatening its biodiversity and proper functioning. The objective of this study was to assess the effects of the exotic Tamarix species on the soil physicochemical properties vis-à-vis the indigenous Tamarix at the Leeu River in the Western Cape Province, of South Africa where they are purvasive. Three transects were laid from the riverbank towards the outer land, where the exotic followed by the native Tamarix species predominantly occurred. Soil was sampled from three points per transect and three soil depths (0-10, 10-20 and 20-30 cm) per point in winter and summer to determine selected soil physicochemical properties. The results showed that total nitrogen (TN), total carbon (TC), Sodium (Na), Potassium (K) and Magnesium (Mg) concentrations under the native and exotic Tamarix species were significantly higher than those in the open land without Tamarix species. The salinity under the native and exotic Tamarix species was greater (P < 0.05) in the topsoils (0-10 cm) than in the deeper soils (20-30 cm) with 5.05 mS cm-1 and 4.73 mS cm-1, respectively. Soil electrical conductivity (EC) was higher (P < 0.05) during the winter season under the exotic Tamarix species (5.05 mS cm-1) followed by the native species (4.73 mS cm-1) and it was the lowest in the control (0.16 mS cm-1) at 0-10 cm soil depth. Similarly, sodium and sodium absorption ratios (SAR) under the native and exotic Tamarix species were significantly greater than those in the control. The highest levels (P < 0.05) of TC were recorded at the topsoil (0-10 cm soil depth) under the exotic Tamarix species (1.17%), followed by the native Tamarix (1.07%) with the control recording the lowest (0.53%). There were no significant differences (P < 0.05) in K, TC, TN and SOC concentrations at lower soil depths (20-30 cm). The soil texture was significantly affected by the Tamarix species. The soil bulk density was lower under the exotic Tamarix followed by native Tamarix species than the control soils. The soil volumetric water content was higher under the exotic Tamarix species compared to the control. This study concludes that the invasion of the exotic and native Tamarix species altered the soil properties underneath and created conducive soil conditions for their predominance.

31. SaliVISION: a rapid saliva-based COVID-19 screening and diagnostic test with high sensitivity and specificity.

Sci Rep

2022 Apr 6

DeFina SM, Wang J, Yang L

32. DNA damage alters EGFR signaling and reprograms cellular response via Mre-11.

Sci Rep

2022 Apr 6

Volman Y, Hefetz R, Galun E

33. Characterization and molecular docking study of cathepsin L inhibitory peptides (SnuCalCpIs) from Calotropis procera R. Br.

Sci Rep

2022 Apr 6

Kwon CW(#), Yeo S(#), Chang PS.

34. The first family of application-specific integrated circuits for programmable and reconfigurable metasurfaces.

Sci Rep

2022 Apr 6

Petrou L, Kossifos KM, Antoniades MA

35. Acute-phase serum amyloid A for early detection of hepatocellular carcinoma in cirrhotic patients with low AFP level.

Sci Rep

2022 Apr 6

Wu JL, Su TH, Chen PJ

36. Assessment of the predictive potential of cognitive scores from retinal images and retinal fundus metadata via deep learning using the CLSA database.

Sci Rep

2022 Apr 6

Corbin D, Lesage F.

37. Mapping the wildland-urban interface in California using remote sensing data.

Sci Rep

2022 Apr 6

Li S, Dao V, Kumar M

38. Monitoring of SARS-CoV-2 antibodies using dried blood spot for at-home collection.

Sci Rep

2022 Apr 6

Miesse PK, Collier BB, Grant RP.

39. In.To. COVID-19 socio-epidemiological co-causality.

Sci Rep

2022 Apr 6

Galbraith E, Li J, Rio-Vilas VJD

Social media can forecast disease dynamics, but infoveillance remains focused on infection spread, with little consideration of media content reliability and its relationship to behavior-driven epidemiological outcomes. Sentiment-encoded social media indicators have been poorly developed for expressed text to forecast healthcare pressure and infer population risk-perception patterns. Here we introduce Infodemic Tomography (InTo) as the first web-based interactive infoveillance cybertechnology that forecasts and visualizes spatio-temporal sentiments and healthcare pressure as a function of social media positivity (i.e., Twitter here), considering both epidemic information and potential misinformation. Information spread is measured on volume and retweets, and the Value of Misinformation (VoMi) is introduced as the impact on forecast accuracy where misinformation has the highest dissimilarity in information dynamics. We validated InTo for COVID-19 in New Delhi and Mumbai by inferring distinct socio-epidemiological risk-perception patterns. We forecast weekly hospitalization and cases using ARIMA models and interpolate spatial hospitalization using geostatistical kriging on inferred risk perception curves between tweet positivity and epidemiological outcomes. Geospatial tweet positivity tracks accurately [Formula: see text]60[Formula: see text] of hospitalizations and forecasts hospitalization risk hotspots along risk aversion gradients. VoMi is higher for risk-prone areas and time periods, where misinformation has the highest non-linear predictability, with high incidence and positivity manifesting popularity-seeking social dynamics. Hospitalization gradients, VoMi, effective healthcare pressure and spatial model-data gaps can be used to predict hospitalization fluxes, misinformation, healthcare capacity gaps and surveillance uncertainty. Thus, InTo is a participatory instrument to better prepare and respond to public health crises by extracting and combining salient epidemiological and social surveillance at any desired space-time scale.

40. Association mapping of autumn-seeded rye (Secale cereale L.) reveals genetic linkages between genes controlling winter hardiness and plant development.

Sci Rep

2022 Apr 6

Båga M, Bahrani H, Larsen J

41. Development and exploration of novel substituted thiosemicarbazones as inhibitors of aldose reductase via in vitro analysis and computational study.

Sci Rep

2022 Apr 6

Imran A, Shehzad MT, Shah SJA

42. Complex drought patterns robustly explain global yield loss for major crops.

Sci Rep

2022 Apr 6

Santini M, Noce S, Antonelli M

43. Impact of rice paddy agriculture on habitat usage of migratory shorebirds at the rice paddy scale in Korea.

Sci Rep

2022 Apr 6

Choi SH, Choi G, Nam HK.

44. Enhanced processing of aversive stimuli on embodied artificial limbs by the human amygdala.

Sci Rep

2022 Apr 6

Fourcade A, Schmidt TT, Nierhaus T

45. Excitatory neurons in paraventricular hypothalamus contributed to the mechanism underlying acupuncture regulating the swallowing function.

Sci Rep

2022 Apr 6

Yuan S, Deng B, Ye Q

46. An analysis of student essays on medical leadership and its educational implications in South Korea.

Sci Rep

2022 Apr 6

Lee IR(#), Jung H(#), Lee Y

47. Wildmeat consumption and child health in Amazonia.

Sci Rep

2022 Apr 6

Carignano Torres P, Morsello C, Orellana JDY

48. System dynamics modeling of lake water management under climate change.

Sci Rep

2022 Apr 6

Bozorg-Haddad O, Dehghan P, Zolghadr-Asli B

Lake Urmia, the twentieth largest lake in the world, is the most valuable aquatic ecosystem in Iran. The lake water level has decreased in recent years due to human activities and climate change. Several studies have highlighted the significant roles of climatic and anthropogenic factors on the shrinkage of the lake. Management policies for water resources harvesting must be adopted to adapt to climate change and avoid the consequent problems stemming from the drought affecting Lake Urmia, and rationing must be applied to the upstream water demands. This study analyzes strategies and evaluates their effectiveness in overcoming the Urmia Lake crisis. Specifically, system dynamics analysis was performed for simulating the water volume of Lake Urmia, and the Hadley Centre coupled model was applied to project surface temperature and precipitation for two future periods: 2021-2050 and 2051-2080. Six management scenarios were considered for decreasing the allocation of agricultural water demand corresponding to two options: (1) one-reservoir option (Bukan reservoir only), and (2) six-reservoir option. The net inflow of Urmia Lake was simulated for the two future periods with the IHACRES model and with artificial neural network models under the six management scenarios. The annual average volumes of Lake Urmia would be 30 × 109 and 12 × 109 m3 over the first and second future periods, respectively, without considering the management scenarios. The lake volumes would rise by about 50% and 75% for the first and second periods, respectively under the management scenarios that involve strict protective measures and elimination of the effect of all dams and their reservoirs. Implementing strict measures would increase the annual average lake volume to 21 × 109 m3 in the second period; yet, this volume would be less than the long-term average and strategic volume. The human water use would be completely eliminated under Scenario 6. Nevertheless, Lake Urmia would experience a considerable loss of storage because of drought.

49. Effect of vitamin E supplementation on cardiometabolic risk factors, inflammatory and oxidative markers and hormonal functions in PCOS (polycystic ovary syndrome): a systematic review and meta-analysis.

Sci Rep

2022 Apr 6

Tefagh G, Payab M(#), Qorbani M

50. An ambient air quality evaluation model based on improved evidence theory.

Sci Rep

2022 Apr 6

Sun Q, Zhang T, Wang X

51. Mechanical and microstructural performance of concrete containing high-volume of bagasse ash and silica fume.

Sci Rep

2022 Apr 6

Amin MN, Ahmad A, Shahzada K

In this study, researchers examined the effect of replacing a high-volume of cement with sugarcane bagasse ash (BA) and silica fume (SF). In addition to the control, three binary and three ternary blends of concrete containing different percentages of cement/BA and cement/BA/SF were tested to determine the various mechanical and microstructural properties of concrete. For each mix, eighteen cylindrical concrete specimens were cast followed by standard curing (moist at 20 °C) to test the compressive and tensile strengths of three identical specimens at 7, 28, and 91 days. The test results indicated that the binary mix with 20% BA and ternary mix with 33% BA and 7% SF exhibited higher strengths than all the other mixes, including the control. The higher strengths of these mixes are also validated by their lower water absorption and apparent porosity than the other mixes. Following mechanical testing, the micro and pore structures of all mixes were investigated by performing scanning electron microscopy/energy-dispersive X-ray spectroscopy (SEM-EDS), Fourier transform infrared (FTIR) spectroscopy, thermogravimetric analysis (TGA), and nitrogen (N2) adsorption isotherm analysis. In SEM-EDS analysis, a dense and compact microstructure was observed for the BA20 and BA33SF7 mixtures due to the formation of high-density C-S-H and C-H phases. The formation of a large amount of C-S-H phases was observed through FTIR, where a prominent shift in peaks from 955 to 970 cm-1 was observed in the spectra of these mixes. Moreover, in N2 adsorption isotherm analysis, a decrease in the intruded pore volume and an increase in the BET surface area of the paste matrix indicate the densification of the pore structure of these mixes. As observed through TGA, a reduction in the amount of the portlandite phase in these mixes leads to the formation of their more densified micro and pore structures. The current findings indicate that BA (20%) and its blend with SF (40%) represents a potential revenue stream for the development of sustainable and high-performance concretes in the future.

52. Improved method of fire hazard assessment taking into account the effect of the primary temperature of a coal seam on the desorption ratio of gas indicators.

Sci Rep

2022 Apr 5

Więckowski M, Howaniec N, Smoliński A.

53. National trends in ideal cardiovascular health among adults in Bhutan from three cross-sectional surveys in 2007, 2014, and 2019.

Sci Rep

2022 Apr 5

Pengpid S, Peltzer K.

54. Fusion of fully integrated analog machine learning classifier with electronic medical records for real-time prediction of sepsis onset.

Sci Rep

2022 Apr 5

Sadasivuni S(#), Saha M(#), Bhatia N

55. Anxiety symptoms, rule learning, and cognitive flexibility in non-clinical psychosis.

Sci Rep

2022 Apr 5

Park JS, Damme KSF, Kuhney FS

56. Assessment of the epi-pericardial fibrotic substrate by collagen-targeted probes.

Sci Rep

2022 Apr 5

Ezeani M, Noor A, Donnelly PS

57. Intravascular ultrasound-factors associated with slow flow following rotational atherectomy in heavily calcified coronary artery.

Sci Rep

2022 Apr 5

Jinnouchi H, Sakakura K, Taniguchi Y

58. Applicability of the linearized Poisson-Boltzmann theory to contact angle problems and application to the carbon dioxide-brine-solid systems.

Sci Rep

2022 Apr 5

Amadu M, Miadonye A.

59. A microbiome study reveals the potential relationship between the bacterial diversity of a gymnastics hall and human health.

Sci Rep

2022 Apr 5

Liang Z, Dong CB, Liang H

Currently, investigations on the microbiota of sports centers and related facilities have been carried out in some countries, which showed that Microsporum gypseum, Trichophyton mentagrophytes and T. tonsurans are important dermatoprotofungi. In China, some research on athletes and sports equipment between the fungal community and public health has made some interesting achievements. However, the bacterial group among them has not been reported. Therefore, The aim of this study was to uncover (I) gymnastic equipment is there potential pathogenic factors and (ii) is there any difference in the biomarker of bacterial in different types of gymnastic room? The samples were collected from the gymnastics halls of one university in western China and main sports equipment, including gymnastics carpets, moving barres, hoops and balls, as well as wall bars, parallel bars and horizontal bars. The 16S rDNA of all the samples was sequenced, and the analyses were performed using FaproTax, Bug base function prediction and Line Discriminant Analysis (LDA) Effect Size. A 16S rDNA sequence analysis revealed abundant bacterial species biodiversity on gymnasts and apparatuses from two gymnastics halls at a university in western China. An analysis using the FaproTax and Bugbase functional prediction platforms showed that there were some opportunistic pathogens on the athletes and equipment from the Rhythmic Gymnastics (RG) and Artistic Gymnastics (AG) halls, such as Staphylococcus and Corynebacteiaceae. Infectious agents associated with cancer induction and development, such as Ruminococcaceae, Veillonellaceae and Moraxellaceae, as well as microbial toxin producers with a potential impact on human health, were also detected. According to a line discriminant analysis (LDA effect size), the bacterial biomarker groups of the two gymnasiums were different at the phylum-genus level: for RG, Erysipelatoclostridium, Lachnospiraceae and Bacteroidales, while for AG, Rhizobiales. Based on the results of the investigation, we suggest that more comprehensive consideration should be given to indoor microbial biodiversity and related public health problems in school gymnasiums.

60. Influence of infrastructure, ecology, and underpass-dimensions on multi-year use of Standard Gauge Railway underpasses by mammals in Tsavo, Kenya.

Sci Rep

2022 Apr 5

Lala F, Chiyo PI, Omondi P

61. Metasurface magnetless specular isolator.

Sci Rep

2022 Apr 5

Lavigne G, Kodera T, Caloz C.

62. Lipid phosphate phosphatase 3 in smooth muscle cells regulates angiotensin II-induced abdominal aortic aneurysm formation.

Sci Rep

2022 Apr 5

Van Hoose PM, Yang L, Kraemer M

63. Halotolerant biofilm-producing rhizobacteria mitigate seawater-induced salt stress and promote growth of tomato.

Sci Rep

2022 Apr 4

Haque MM, Biswas MS, Mosharaf MK

64. Psychological distress and mental health trajectories during the COVID-19 pandemic in Argentina: a longitudinal study.

Sci Rep

2022 Apr 4

Fernández RS, Crivelli L, Guimet NM

65. Comparative mitogenomics and phylogenetics of the family Carangidae with special emphasis on the mitogenome of the Indian Scad Decapterus russelli.

Sci Rep

2022 Apr 4

Jose A, Sukumaran S, Mukundan LP

66. Investigation of Fusobacterium Nucleatum in saliva and colorectal mucosa: a pilot study.

Sci Rep

2022 Apr 4

Idrissi Janati A, Karp I, Von Renteln D

67. Proteomic analysis of the periodontal pathogen Prevotella intermedia secretomes in biofilm and planktonic lifestyles.

Sci Rep

2022 Apr 4

Karched M, Bhardwaj RG, Qudeimat M

68. Deposition, microstructure and nanoindentation of multilayer Zr nitride and carbonitride nanostructured coatings.

Sci Rep

2022 Apr 4

Ul-Hamid A.

Nitrides, carbides, and carbonitrides of transition metal elements like Zr, W, Ti, etc. are generally employed to produce hard coatings. Zirconium-based hard coatings have shown useful applications in the areas of tribology, biomedicine and electrical due to their high thermal stability, hardness, biocompatibility, good erosion, wear, and corrosion resistance. In this study, we created homogeneous and tenacious nanostructured hard coatings based on Zr with good mechanical properties. The magnetron sputter deposition technique was utilized to coat stainless steel 316L substrates with multilayers of Zr/ZrN and ZrN/ZrCN with individual layer thicknesses of 250 and 500 nm for each coating composition. The deposition conditions were adjusted to create two different coating thicknesses of 2 and 3 µm. The thickness of the coating was confirmed using Calotest and the coatings' morphology and elemental composition were determined utilizing the atomic force microscope and scanning electron microscope equipped with energy dispersive x-ray spectrometer. Coating thickness and adhesion were measured using cross-sectional samples and XRD was utilized to analyze the coatings structure. Nanoindenter was employed to determine the instrumental nanoindentation hardness and elastic modulus. The influence of coating thickness on tribological behavior was further investigated using the ratio of nanohardness-to-elastic modulus (H/E). No evidence of decohesion was observed at the substrate/coatings interface, and the grains of all the coatings were observed to show columnar growth which were homogeneous, compact and dense. The grains of the ZrN/ZrCN coatings were observed to be denser, finer and more compact compared to those of the Zr/ZrN coatings. Correspondingly, higher hardness, modulus and H/E values were exhibited by ZrN/ZrCN than Zr/ZrN coatings. This suggests that the ZrN/ZrCN coatings are capable of exhibiting better wear resistance and fracture toughness. The coatings developed in this investigation are anticipated to be suitable for applications in tribology due to their excellent hardness and H/E properties.

69. Coupling genetic structure analysis and ecological-niche modeling in Kersting's groundnut in West Africa.

Sci Rep

2022 Apr 4

Coulibaly M, Idohou R, Akohoue F

70. Biosynthesis of S-adenosyl-methionine enhances aging-related defects in Drosophila oogenesis.

Sci Rep

2022 Apr 4

Hayashi Y, Kashio S, Murotomi K

71. Housing environment and mental health of Europeans during the COVID-19 pandemic: a cross-country comparison.

Sci Rep

2022 Apr 4

Keller A, Groot J, Matta J

72. Addressing the range anxiety of battery electric vehicles with charging en route.

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2022 Apr 4

Chakraborty P, Parker R, Hoque T

Battery electric vehicles (BEVs) have emerged as a promising alternative to traditional internal combustion engine (ICE) vehicles due to benefits in improved fuel economy, lower operating cost, and reduced emission. BEVs use electric motors rather than fossil fuels for propulsion and typically store electric energy in lithium-ion cells. With rising concerns over fossil fuel depletion and the impact of ICE vehicles on the climate, electric mobility is widely considered as the future of sustainable transportation. BEVs promise to drastically reduce greenhouse gas emissions as a result of the transportation sector. However, mass adoption of BEVs faces major barriers due to consumer worries over several important battery-related issues, such as limited range, long charging time, lack of charging stations, and high initial cost. Existing solutions to overcome these barriers, such as building more charging stations, increasing battery capacity, and stationary vehicle-to-vehicle (V2V) charging, often suffer from prohibitive investment costs, incompatibility to existing BEVs, or long travel delays. In this paper, we propose Peer-to-Peer Car Charging (P2C2), a scalable approach for charging BEVs that alleviates the need for elaborate charging infrastructure. The central idea is to enable BEVs to share charge among each other while in motion through coordination with a cloud-based control system. To re-vitalize a BEV fleet, which is continuously in motion, we introduce Mobile Charging Stations (MoCS), which are high-battery-capacity vehicles used to replenish the overall charge in a vehicle network. Unlike existing V2V charging solutions, the charge sharing in P2C2 takes place while the BEVs are in-motion, which aims at minimizing travel time loss. To reduce BEV-to-BEV contact time without increasing manufacturing costs, we propose to use multiple batteries of varying sizes and charge transfer rates. The faster but smaller batteries are used for charge transfer between vehicles, while the slower but larger ones are used for prolonged charge storage. We have designed the overall P2C2 framework and formalized the decision-making process of the cloud-based control system. We have evaluated the effectiveness of P2C2 using a well-characterized simulation platform and observed dramatic improvement in BEV mobility. Additionally, through statistical analysis, we show that a significant reduction in carbon emission is also possible if MoCS can be powered by renewable energy sources.

73. Analytical modelling of soil porosity and bulk density across the soil organic matter and land-use continuum.

Sci Rep

2022 Apr 30

Robinson DA, Thomas A, Reinsch S

74. Deep parameter-free attention hashing for image retrieval.

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2022 Apr 30

Yang W, Wang L, Cheng S.

75. Molecular dynamics simulations of the secondary-binding site in disaccharide-modified glycopeptide antibiotics.

Sci Rep

2022 Apr 30

Olademehin OP, Shuford KL, Kim SJ.

76. Prevalence of anemia and association with mortality in community-dwelling elderly in Thailand.

Sci Rep

2022 Apr 30

Karoopongse E, Srinonprasert V, Chalermsri C

Anemia is one of the most common health problems in the elderly in low and middle income countries. Evidence from studies in high income countries suggests that the presence of anemia may predict mortality. We aimed to estimate the prevalence of anemia and the determine the relationship of hemoglobin, mean corpuscular volume (MCV) and mortality in community dwelling Thai elderly. Data from subjects aged ≥ 60 years from the Fourth Thai National Health Examination Survey were analyzed. Comorbidity and hematologic indexes including MCV were obtained. The Cox proportional hazard model was applied to explore associations with mortality. Data from 8,935 subjects were obtained. The mean age of participants was 69.2 years (SD 6.8). 3446 (38.2%) of subjects had anemia; 1931(56%) of these were classified as mild and normocytic. With a total 51,268 person-year of follow up, 753 participants with anemia died, and the cumulative all-cause mortality was 38.5 per 1,000 person-years. The presence of anemia was associated with an increased risk of mortality with HR of 1.66 (95% CI = 1.50-1.84 , p < 0.001). Among subjects with low MCV, hemoglobin level < 10 g/dl in men and < 9 g/dl in women significantly increased the risk of mortality (HR of 2.71, 95% CI = 1.88-3.91 and HR of 3.14, 95%CI = 2.11-4.67, respectively) Persons with anemia and normal MCV, the association with mortality was evident at hemoglobin levels below 11 g/dl for both males and females. (HR of 1.98, 95% CI = 1.67-2.35). Anemia is a moderate to severe public health significant in the population for community dwelling elderly in Thailand. At the same level of Hemoglobin, low MCV population seem to have lower mortality rate than normal MCV. Systematic screening for anemia should be implemented to identify patients at increased risk of mortality. The future research should be focus on causes of anemia and factors contributing to increased mortality in normal to high MCV would be of interest. If this could lead to identifying modifiable causes, it would be beneficial for improving mortality risk among older people.

77. Rhegmatogenous retinal detachment induces more severe macular capillary changes than central serous chorioretinopathy.

Sci Rep

2022 Apr 29

Lee J(#), Seo EJ(#), Yoon YH.

78. Identification of an autophagy-related gene signature for predicting prognosis and immune activity in pancreatic adenocarcinoma.

Sci Rep

2022 Apr 29

Deng J, Zhang Q, Lv L

Adenocarcinoma of the pancreas (PAAD) is a cancerous growth that deteriorates rapidly and has a poor prognosis. Researchers are investigating autophagy in PAAD to identify a new biomarker and treatment target. An autophagy-related gene (ARG) model for overall survival (OS) was constructed using multivariate Cox regression analyses. A cohort of the Cancer Genome Atlas (TCGA)-PAAD was used as the training group as a basis for model construction. This prediction model was validated with several external datasets. To evaluate model performance, the analysis with receiver operating characteristic curves (ROC) was performed. The Human Protein Atlas (HPA) and Cancer Cell Line Encyclopedia (CCLE) were investigated to validate the effects of ARGs expression on cancer cells. Comparing the levels of immune infiltration between high-risk and low-risk groups was finished through the use of CIBERSORT. The differentially expressed genes (DEGs) between the low-/high-risk groups were analyzed further via Gene Ontology biological process (GO-BP) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analyses, which were used to identify potential small-molecule compounds in Connectivity Map (CMap), followed by half-maximal inhibitory concentration (IC50) examination with PANC-1 cells. The risk score was finally calculated as follows: BAK1 × 0.34 + ITGA3 × 0.38 + BAG3 × 0.35 + APOL1 × 0.26-RAB24 × 0.67519. ITGA3 and RAB24 both emerged as independent prognostic factors in multivariate Cox regression. Each PAAD cohort had a significantly shorter OS in the high-risk group than in the low-risk group. The high-risk group exhibited infiltration of several immune cell types, including naive B cells (p = 0.003), plasma cells (p = 0.044), and CD8 T cells (nearly significant, p = 0.080). Higher infiltration levels of NK cells (p = 0.025), resting macrophages (p = 0.020), and mast cells (p = 0.007) were found in the high-risk group than the low-risk group. The in vitro and in vivo expression of signature ARGs was consistent in the CCLE and HPA databases. The top 3 enriched Gene Ontology biological processes (GO-BPs) were signal release, regulation of transsynaptic signaling, and modulation of chemical synaptic transmission, and the top 3 enriched Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways were MAPK, cAMP, and cell adhesion molecules. Four potential small-molecule compounds (piperacetazine, vinburnine, withaferin A and hecogenin) that target ARGs were also identified. Taking the results together, our research shows that the ARG signature may serve as a useful prognostic indicator and reveal potential therapeutic targets in patients with PAAD.

79. Using de novo genome assembly and high-throughput sequencing to characterize the MHC region in a non-model bird, the Eurasian coot.

Sci Rep

2022 Apr 29

Pikus E, Minias P.

80. A turning point in the bacterial nanocellulose production employing low doses of gamma radiation.

Sci Rep

2022 Apr 29

Al-Hagar OEA, Abol-Fotouh D.

81. Comprehensive decoding mental processes from Web repositories of functional brain images.

Sci Rep

2022 Apr 29

Menuet R(#), Meudec R(#), Dockès J

82. Differences in visual field loss pattern when transitioning from SITA standard to SITA faster.

Sci Rep

2022 Apr 29

Le CT, Fiksel J, Ramulu P

83. Increased NUSAP1 expression is associated with lymph node metastasis and survival prognosis in bladder urothelial carcinoma.

Sci Rep

2022 Apr 29

Hou J(#), Lu Z(#), Liu X(#)

84. Proteomics of lung tissue reveals differences in inflammation and alveolar-capillary barrier response between atelectasis and aerated regions.

Sci Rep

2022 Apr 29

Rashid A, Zeng C, Motta-Ribeiro G

85. The relationship of muscular endurance and coordination and dexterity with behavioral and neuroelectric indices of attention in preschool children.

Sci Rep

2022 Apr 29

Kao SC, Tsai YJ, Hsieh SS

86. Phosphate-regulated expression of the SARS-CoV-2 receptor-binding domain in the diatom Phaeodactylum tricornutum for pandemic diagnostics.

Sci Rep

2022 Apr 29

Slattery SS, Giguere DJ, Stuckless EE

87. Doping of carbon nanotubes by halogenated solvents.

Sci Rep

2022 Apr 29

Taborowska P, Stando G, Sahlman M

88. Postural control during turn on the light task assisted by functional electrical stimulation in post stroke subjects.

Sci Rep

2022 Apr 29

Sousa ASP, Moreira J, Silva C

89. Metal nanoparticles functionalized with nutraceutical Kaempferitrin from edible Crotalaria juncea, exert potent antimicrobial and antibiofilm effects against Methicillin-resistant Staphylococcus aureus.

Sci Rep

2022 Apr 29

Shamprasad BR(#), Lotha R(#), Nagarajan S

90. Organocatalytic activity of granaticin and its involvement in bactericidal function.

Sci Rep

2022 Apr 29

Nishiyama T, Enomoto N, Nagayasu R

91. GC-MS and LC-TOF-MS profiles, toxicity, and macrophage-dependent in vitro anti-osteoporosis activity of Prunus africana (Hook f.) Kalkman Bark.

Sci Rep

2022 Apr 29

Komakech R, Shim KS, Yim NH

Osteoporosis affects millions of people worldwide. As such, this study assessed the macrophage-dependent in vitro anti-osteoporosis, phytochemical profile and hepatotoxicity effects in zebrafish larvae of the stem bark extracts of P. africana. Mouse bone marrow macrophages (BMM) cells were plated in 96-well plates and treated with P. africana methanolic bark extracts at concentrations of 0, 6.25, 12.5, 25, and 50 µg/ml for 24 h. The osteoclast tartrate-resistant acid phosphatase (TRAP) activity and cell viability were measured. Lipopolysaccharides (LPS) induced Nitrite (NO) and interleukin-6 (IL-6) production inhibitory effects of P. africana bark extracts (Methanolic, 150 µg/ml) and β-sitosterol (100 µM) were conducted using RAW 264.7 cells. Additionally, inhibition of IL-1β secretion and TRAP activity were determined for chlorogenic acid, catechin, naringenin and β-sitosterol. For toxicity study, zebrafish larvae were exposed to different concentrations of 25, 50, 100, and 200 µg/ml P. africana methanolic, ethanolic and water bark extracts. Dimethyl sulfoxide (0.05%) was used as a negative control and tamoxifen (5 µM) and dexamethasone (40 µM or 80 µM) were positive controls. The methanolic P. africana extracts significantly inhibited (p < 0.001) TRAP activity at all concentrations and at 12.5 and 25 µg/ml, the extract exhibited significant (p < 0.05) BMM cell viability. NO production was significantly inhibited (all p < 0.0001) by the sample. IL-6 secretion was significantly inhibited by P. africana methanolic extract (p < 0.0001) and β-sitosterol (p < 0.0001) and further, chlorogenic acid and naringenin remarkably inhibited IL-1β production. The P. africana methanolic extract significantly inhibited RANKL-induced TRAP activity. The phytochemical study of P. africana stem bark revealed a number of chemical compounds with anti-osteoporosis activity. There was no observed hepatocyte apoptosis in the liver of zebrafish larvae. In conclusion, the stem bark of P. africana is non-toxic to the liver and its inhibition of TRAP activity makes it an important source for future anti-osteoporosis drug development.

92. Trends in female breast cancer incidence, mortality, and survival in Austria, with focus on age, stage, and birth cohorts (1983-2017).

Sci Rep

2022 Apr 29

Ilic L, Haidinger G, Simon J

93. Age and sex effects across the blood proteome after ionizing radiation exposure can bias biomarker screening and risk assessment.

Sci Rep

2022 Apr 29

Langen B, Vorontsov E, Spetz J

Molecular biomarkers of ionizing radiation (IR) exposure are a promising new tool in various disciplines: they can give necessary information for adaptive treatment planning in cancer radiotherapy, enable risk projection for radiation-induced survivorship diseases, or facilitate triage and intervention in radiation hazard events. However, radiation biomarker discovery has not yet resolved the most basic features of personalized medicine: age and sex. To overcome this critical bias in biomarker identification, we quantitated age and sex effects and assessed their relevance in the radiation response across the blood proteome. We used high-throughput mass spectrometry on blood plasma collected 24 h after 0.5 Gy total body irradiation (15 MV nominal photon energy) from male and female C57BL/6 N mice at juvenile (7-weeks-old) or adult (18-weeks-old) age. We also assessed sex and strain effects using juvenile male and female BALB/c nude mice. We showed that age and sex created significant effects in the proteomic response regarding both extent and functional quality of IR-induced responses. Furthermore, we found that age and sex effects appeared non-linear and were often end-point specific. Overall, age contributed more to differences in the proteomic response than sex, most notably in immune responses, oxidative stress, and apoptotic cell death. Interestingly, sex effects were pronounced for DNA damage and repair pathways and associated cellular outcome (pro-survival vs. pro-apoptotic). Only one protein (AHSP) was identified as a potential general biomarker candidate across age and sex, while GMNN, REG3B, and SNCA indicated some response similarity across age. This low yield advocated that unisex or uniage biomarker screening approaches are not feasible. In conclusion, age- and sex-specific screening approaches should be implemented as standard protocol to ensure robustness and diagnostic power of biomarker candidates. Bias-free molecular biomarkers are a necessary progression towards personalized medicine and integral for advanced adaptive cancer radiotherapy and risk assessment.

94. Genome-wide association study identifies loci and candidate genes for grain micronutrients and quality traits in wheat (Triticum aestivum L.).

Sci Rep

2022 Apr 29

Rathan ND, Krishna H, Ellur RK

95. Sustainable human population density in Western Europe between 560.000 and 360.000 years ago.

Sci Rep

2022 Apr 28

Rodríguez J, Willmes C, Sommer C

96. A novel soluble epoxide hydrolase vaccine protects murine cardiac muscle against myocardial infarction.

Sci Rep

2022 Apr 28

Kitsuka T, Shiraki A, Oyama JI

97. Concordance between biparametric MRI, transperineal targeted plus systematic MRI-ultrasound fusion prostate biopsy, and radical prostatectomy pathology.

Sci Rep

2022 Apr 28

Noh TI, Shim JS, Kang SG

98. A randomised study to assess the nicotine pharmacokinetics of an oral nicotine pouch and two nicotine replacement therapy products.

Sci Rep

2022 Apr 28

Azzopardi D, Ebajemito J, McEwan M

99. Differences in total stored C and N in dryland red soil caused by different long-term fertilization practices.

Sci Rep

2022 Apr 28

Xi W, Liu K, Yu X

100. Evaluation of corneal nerves and dendritic cells by in vivo confocal microscopy after Descemet's membrane keratoplasty for bullous keratopathy.

Sci Rep

2022 Apr 28

Shimizu T, Hayashi T, Ishida A

101. The importance of pH adjustment for preventing fibrin glue dissolution in the stomach: an in vitro study.

Sci Rep

2022 Apr 28

Takegawa Y, Takao T, Sakaguchi H

102. Femtosecond laser-assisted corneal transplantation with a low-energy, liquid-interface system.

Sci Rep

2022 Apr 28

Liu YC(#), Morales-Wong F(#), Patil M

103. Performance of innovative nanomaterials for bone remains consolidation and effect on (14)C dating and on palaeogenetic analysis.

Sci Rep

2022 Apr 28

Porpora F, Zaro V, Liccioli L

104. Full factorial design and dynamic modelling of silent and ultrasound-assisted lead and cadmium removal by porous biosorbent.

Sci Rep

2022 Apr 28

Ahmed SB, Dobre T, Kamar FH

105. Laser ablation assisted micropattern screen printed transduction electrodes for sensing applications.

Sci Rep

2022 Apr 28

Rehmani MAA, Lal K, Shaukat A

106. Dominant transcript expression profiles of human protein-coding genes interrogated with GTEx dataset.

Sci Rep

2022 Apr 28

Tung KF, Pan CY, Lin WC.

107. Airway epithelial interferon response to SARS-CoV-2 is inferior to rhinovirus and heterologous rhinovirus infection suppresses SARS-CoV-2 replication.

Sci Rep

2022 Apr 28

Vanderwall ER, Barrow KA, Rich LM

108. Strength training alters the tissue fatty acids profile and slightly improves the thermogenic pathway in the adipose tissue of obese mice.

Sci Rep

2022 Apr 28

de Melo DG, Anaruma CP, da Cruz Rodrigues KC

Obesity is a disease characterized by the exacerbated increase of adipose tissue. A possible way to decrease the harmful effects of excessive adipose tissue is to increase the thermogenesis process, to the greater energy expenditure generated by the increase in heat in the body. In adipose tissue, the thermogenesis process is the result of an increase in mitochondrial work, having as substrate H+ ions, and which is related to the increased activity of UCP1. Evidence shows that stress is responsible for increasing the greater induction of UCP1 expression via β-adrenergic receptors. It is known that physical exercise is an important implement for sympathetic stimulation promoting communication between norepinephrine/epinephrine with membrane receptors. Thus, the present study investigates the influence of short-term strength training (STST) on fatty acid composition, lipolysis, lipogenesis, and browning processes in the subcutaneous adipose tissue (sWAT) of obese mice. For this, Swiss mice were divided into three groups: lean control, obesity sedentary, and obese strength training (OBexT). Obese animals were fed a high-fat diet for 14 weeks. Trained obese animals were submitted to 7 days of strength exercise. It was demonstrated that STST sessions were able to reduce fasting glycemia. In the sWAT, the STST was able to decrease the levels of the long-chain fatty acids profile, saturated fatty acid, and palmitic fatty acid (C16:0). Moreover, it was showed that STST did not increase protein levels responsible for lipolysis, the ATGL, ABHD5, pPLIN1, and pHSL. On the other hand, the exercise protocol decreased the expression of the lipogenic enzyme SCD1. Finally, our study demonstrated that the STST increased browning process-related genes such as PGC-1α, PRDM16, and UCP1 in the sWAT. Interestingly, all these biomolecular mechanisms have been observed independently of changes in body weight. Therefore, it is concluded that short-term strength exercise can be an effective strategy to initiate morphological changes in sWAT.

109. The role of neurotrophin genes involved in the vulnerability to gambling disorder.

Sci Rep

2022 Apr 28

Solé-Morata N(#), Baenas I(#), Etxandi M

110. Reservoir computing with dielectric relaxation at an electrode-ionic liquid interface.

Sci Rep

2022 Apr 28

Koh SG, Shima H, Naitoh Y

111. Weak spin-flip scattering in Pd(89)Ni(11) interlayer of NbN-based ferromagnetic Josephson junctions.

Sci Rep

2022 Apr 27

Pham D, Sugimoto R, Oba K

112. A perspective of scale differences for studying the green total factor productivity of Chinese laying hens.

Sci Rep

2022 Apr 27

Zhong S, Chen X, Li J

113. Extending UTAUT with national identity and fairness to understand user adoption of DCEP in China.

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2022 Apr 27

Wu B, An X, Wang C

114. Correlation between structure, chromaticity, and dielectric properties of calcium copper pyrophosphates, Ca(2-x)Cu(x)P(2)O(7).

Sci Rep

2022 Apr 27

Baitahe R, Sronsri C, Thompho S

115. Compressive behaviour of anisotropic mycelium-based composites.

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2022 Apr 27

Rigobello A, Ayres P.

116. Establishment and a comparative transcriptomic analysis of a male-specific cell line from the African malaria mosquito Anopheles gambiae.

Sci Rep

2022 Apr 27

Krzywinska E, Ferretti L, Krzywinski J.

117. Optimizing antiviral therapy for COVID-19 with learned pathogenic model.

Sci Rep

2022 Apr 27

Dutta A.

118. Real-time segmentation method of billet infrared image based on multi-scale feature fusion.

Sci Rep

2022 Apr 27

Zhang L, Nan Q, Bian S

119. Apparent absence of avian malaria and malaria-like parasites in northern blue-footed boobies breeding on Isla Isabel.

Sci Rep

2022 Apr 27

Roldán-Zurabián F, José Ruiz-López M, de la Puente JM

120. Super-strong magnetic field-dominated ion beam dynamics in focusing plasma devices.

Sci Rep

2022 Apr 27

Morace A, Abe Y, Honrubia JJ

121. Phases of stability during major hydroclimate change ending the Last Glacial in the Levant.

Sci Rep

2022 Apr 27

Müller D, Neugebauer I, Ben Dor Y

122. Universality of political corruption networks.

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2022 Apr 27

Martins AF, da Cunha BR, Hanley QS

123. Superoxide dismutase 6 is required during metamorphosis for the development of properly movable legs in Tribolium castaneum.

Sci Rep

2022 Apr 27

Nishiko M, Sakamoto T, Mun S

124. Obstetric outcomes during delivery hospitalizations among obese pregnant women in the United States.

Sci Rep

2022 Apr 27

Rubens M, Ramamoorthy V, Saxena A

125. Characterization of Klebsiella pneumoniae isolated from patients suspected of pulmonary or bubonic plague during the Madagascar epidemic in 2017.

Sci Rep

2022 Apr 27

Rakotondrasoa A, Andrianonimiadana LM, Rahajandraibe S

126. Automated estimation of cancer cell deformability with machine learning and acoustic trapping.

Sci Rep

2022 Apr 27

Lee OJ, Lim HG, Shung KK

Cell deformability is a useful feature for diagnosing various diseases (e.g., the invasiveness of cancer cells). Existing methods commonly inflict pressure on cells and observe changes in cell areas, diameters, or thickness according to the degree of pressure. Then, the Young's moduli (i.e., a measure of deformability) of cells are estimated based on the assumption that the degrees of the changes are inversely proportional to Young's moduli. However, manual measurements of the physical changes in cells are labor-intensive, and the subjectivity of the operators can intervene during this step, thereby causing considerable uncertainty. Further, because the shapes of cells are nonuniform, we cannot ensure the assumption for linear correlations of physical changes in cells with their deformability. Therefore, this study aims at measuring non-linear elastic moduli of live cells (degrees of cell deformability) automatically by employing conventional neural networks (CNN) and multilayer perceptrons (MLP) while preserving (or enhancing) the accuracy of the manual methods. First, we obtain photomicrographs of cells on multiple pressure levels using single-beam acoustic tweezers, and then, we suggest an image preprocessing method for emphasizing changes in cell areas on the photomicrographs. The CNN model is trained to measure the ratios of the cell area change at each pressure level. Then, we apply the multilayer perceptron (MLP) to learn the correlations of the cell area change ratios according to the pressure levels with cell deformability. The accuracy of the CNN was evaluated using two types of breast cancer cells: MDA-MB-231 (invasive) and MCF-7 (noninvasive). The MLP was assessed using five different beads (Young's moduli from 0.214 to 9.235 kPa), which provides standardized reference data of the non-linear elastic moduli of live cells. Finally, we validated the practicality of the proposed system by examining whether the non-linear elastic moduli estimated by the proposed system can distinguish invasive breast cancer cells from noninvasive ones.

127. Clinical significance of baseline Pan-Immune-Inflammation Value and its dynamics in metastatic colorectal cancer patients under first-line chemotherapy.

Sci Rep

2022 Apr 27

Pérez-Martelo M(#), González-García A(#), Vidal-Ínsua Y

Pan-Immune-Inflammation Value (PIV) has been recently proposed as a new blood-based prognostic biomarker in metastatic colorectal cancer (mCRC). Herein we aimed to validate its prognostic significance and to evaluate its utility for disease monitoring in patients with mCRC receiving first-line chemotherapy. We conducted a single-centre retrospective study involving 130 previously untreated mCRC patients under first-line standard chemotherapy in a real-world scenario. PIV was calculated as (neutrophil count × platelet count × monocyte count)/lymphocyte count at three different time-points: baseline, week 4 after therapy initiation, and at disease progression. We analyzed the influence of baseline PIV on overall survival (OS), progression-free survival (PFS), disease control rate (DCR), and overall response rate (ORR). We also explored the utility of PIV dynamics for disease monitoring. Baseline PIV high was significantly associated with worse OS in univariate [hazard ratio (HR) = 2.10, 95% CI, 1.41-3.15; p = 0.000299] and multivariate (HR = 1.82, 95% CI, 1.15-2.90; p = 0.011) analyses. Baseline PIV was also associated with worse PFS in univariate (HR = 2.04, 95% CI, 1.40-2.97; p = 0.000187) and multivariate (HR = 1.56, 95% CI, 1.05-2.31; p = 0.026) analyses. Baseline PIV was not correlated either with DCR or ORR. Regarding PIV dynamics, there was a statistically significant increase from week 4 to disease progression (p = 0.0003), which was at the expense of cases with disease control as best response (p < 0.0001). In conclusion, this study validates the prognostic significance of baseline PIV in patients with mCRC receiving first-line standard chemotherapy in a real-world scenario. Moreover, it suggests the potential utility of PIV monitoring to anticipate the disease progression among those patients who achieve initial disease control.

128. Comprehensive human amniotic fluid metagenomics supports the sterile womb hypothesis.

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2022 Apr 27

Wang H, Yang GX, Hu Y

129. Analysis of oxidative stress, inflammation and endothelial function following intravenous iron in chronic kidney disease in the Iron and Heart Trial.

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2022 Apr 27

Kassianides X, Allgar V, Macdougall IC

130. Differences between human and machine perception in medical diagnosis.

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2022 Apr 27

Makino T, Jastrzębski S, Oleszkiewicz W

131. The nano- and meso-scale structure of amorphous calcium carbonate.

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2022 Apr 27

Clark SM, Colas B, Jacob DE

Understanding the underlying processes of biomineralization is crucial to a range of disciplines allowing us to quantify the effects of climate change on marine organisms, decipher the details of paleoclimate records and advance the development of biomimetic materials. Many biological minerals form via intermediate amorphous phases, which are hard to characterize due to their transient nature and a lack of long-range order. Here, using Monte Carlo simulations constrained by X-ray and neutron scattering data together with model building, we demonstrate a method for determining the structure of these intermediates with a study of amorphous calcium carbonate (ACC) which is a precursor in the bio-formation of crystalline calcium carbonates. We find that ACC consists of highly ordered anhydrous nano-domains of approx. 2 nm that can be described as nanocrystalline. These nano-domains are held together by an interstitial net-like matrix of water molecules which generate, on the mesoscale, a heterogeneous and gel-like structure of ACC. We probed the structural stability and dynamics of our model on the nanosecond timescale by molecular dynamics simulations. These simulations revealed a gel-like and glassy nature of ACC due to the water molecules and carbonate ions in the interstitial matrix featuring pronounced orientational and translational flexibility. This allows for viscous mobility with diffusion constants four to five orders of magnitude lower than those observed in solutions. Small and ultra-small angle neutron scattering indicates a hierarchically-ordered organization of ACC across length scales that allow us, based on our nano-domain model, to build a comprehensive picture of ACC formation by cluster assembly from solution. This contribution provides a new atomic-scale understanding of ACC and provides a framework for the general exploration of biomineralization and biomimetic processes.

132. Changes to the gut microbiota of a wild juvenile passerine in a multidimensional urban mosaic.

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2022 Apr 27

Maraci Ö, Corsini M, Antonatou-Papaioannou A

133. Bone marrow transplantation induces changes in the gut microbiota that chronically increase the cytokine response pattern of splenocytes.

Sci Rep

2022 Apr 27

Katiraei S, van Diepen JA, Tavares LP

134. Bioimpedance spinal needle provides high success and low complication rate in lumbar punctures of pediatric patients with acute lymphoblastic leukemia.

Sci Rep

2022 Apr 26

Långström S, Huurre A, Kari J

135. A multi-suckling system combined with an enriched housing environment during the growing period promotes resilience to various challenges in pigs.

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2022 Apr 26

Parois SP, Van Der Zande LE, Knol EF

136. Light dependent synthesis of a nucleotide second messenger controls the motility of a spirochete bacterium.

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2022 Apr 26

Xu J(#), Koizumi N(#), Morimoto YV(#)

137. Metamaterial sensor based on rectangular enclosed adjacent triple circle split ring resonator with good quality factor for microwave sensing application.

Sci Rep

2022 Apr 26

Islam MR, Islam MT, M MS

138. Grasp-squeeze adaptation to changes in object compliance leads to dynamic beta-band communication between primary somatosensory and motor cortices.

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2022 Apr 26

Cu H, Lynch L, Huang K

139. Temperature gradient of vertical air column in gravitational field.

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2022 Apr 26

Jeong HM, Park S.

140. Definition of the snoring episode index based on the analyses of snoring parameters and the apnea hypopnea index.

Sci Rep

2022 Apr 26

Kim SG, Cho SW, Kim JW.

141. Imaging furcation defects with low-dose cone beam computed tomography.

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2022 Apr 26

Ruetters M, Gehrig H, Kim TS

142. Multi-angle quantum approximate optimization algorithm.

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2022 Apr 26

Herrman R, Lotshaw PC, Ostrowski J

143. Modeling and characterization of stochastic resistive switching in single Ag(2)S nanowires.

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2022 Apr 26

Frick N(#), Hosseini M(#), Guilbaud D

144. Improved virtual extensometer measurement method in complex multi-fracture situation.

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2022 Apr 26

Chai J, Ouyang Y, Liu J

145. Toward passive BCI: asynchronous decoding of neural responses to direction- and angle-specific perturbations during a simulated cockpit scenario.

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2022 Apr 26

Jalilpour S, Müller-Putz G.

146. General cognitive decline does not account for older adults' worse emotion recognition and theory of mind.

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2022 Apr 26

Kong Q, Currie N, Du K

147. A novel ND1 mitochondrial DNA mutation is maternally inherited in growth hormone transgenesis in amago salmon (Oncorhynchus masou ishikawae).

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2022 Apr 25

Sato T, Goto-Inoue N, Kimishima M

148. Unveiling OASIS family as a key player in hypoxia-ischemia cases induced by cocaine using generative adversarial networks.

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2022 Apr 25

Lee K(#), Kim T(#), Cheon M

149. Using virtual global landmark to improve incidental spatial learning.

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2022 Apr 25

Liu J, Singh AK, Lin CT.

150. Molecular mechanisms of bifunctional vitamin D receptor agonist-histone deacetylase inhibitor hybrid molecules in triple-negative breast cancer.

Sci Rep

2022 Apr 25

Barbier C, Mansour A, Ismailova A

The active form of vitamin D, 1,25-dihydroxyvitamin D (1,25D), and its analogues signal through the nuclear vitamin D receptor (VDR), a ligand-regulated transcription factor, and have been extensively investigated as anticancer agents. 1,25D and its analogs have potential in combination therapies because they exhibit synergistic activities with other anticancer agents such as histone deacetylase inhibitors (HDACi). We have developed a series of hybrid molecules that combine HDACi within the backbone of a VDR agonist and thus represent fully integrated bifunctional molecules. They exhibit anti-tumor efficacy in reducing tumor growth and metastases in an aggressive model of triple-negative breast cancer. However, their solubility is limited by their hydrophobic diarylpentane cores. Our goals here were two-fold: (1) to improve the solubility of hybrids by introducing nitrogen into diarylpentane cores, and (2) to investigate the molecular mechanisms underlying their anti-tumor efficacy by performing comparative gene expression profiling studies with 1,25D and the potent HDACi suberoylanilide hydroxamic acid (SAHA). We found that substituting aryl with pyrydyl rings did not sacrifice bifunctionality and modestly improved solubility. Notably, one compound, AM-193, displayed enhanced potency as a VDR agonist and in cellular assays of cytotoxicity. RNAseq studies in triple negative breast cancer cells revealed that gene expression profiles of hybrids were very similar to that of 1,25D, as was that observed with 1,25D and SAHA combined. The effects of SAHA alone on gene expression were limited and distinct from those 1,25D or hybrids. The combined results suggest that efficacy of hybrids arises from targeting HDACs that do not have a direct role in gene regulation. Moreover, pathways analysis revealed that hybrids regulate numerous genes controlling immune cell infiltration into tumors and suppress the expression of several secreted molecules that promote breast cancer growth and metastasis.

151. Automated segmentation of the fractured vertebrae on CT and its applicability in a radiomics model to predict fracture malignancy.

Sci Rep

2022 Apr 25

Park T, Yoon MA, Cho YC

152. Mixture-modeling approach reveals global and local processes in visual crowding.

Sci Rep

2022 Apr 25

Jimenez M, Kimchi R, Yashar A.

153. Evaluation and application of the CROPGRO-soybean model for determining optimum sowing windows of soybean in the Nigeria savannas.

Sci Rep

2022 Apr 25

Bebeley JF, Kamara AY, Jibrin JM

Soybean production is limited by poor soil fertility and unstable rainfall due to climate variability in the Nigeria savannas. There is a decline in the amount and duration of rainfall as one moves from the south to north of the savanna zones. The use of adapted soybean varieties and optimum sowing windows are avenues to increase productivity in the face of climate variability. Crop simulation models can be used as tools for the evaluation of alternative management options for a particular location, including fertilizer application rates, plant density, sowing dates and land use. In this study, we evaluated the performance of the Cropping System Model (CSM)-CROPGRO-Soybean to determine optimum sowing windows for three contrasting soybean varieties (TGX1835-10E, TGX1904-6F and TGX1951-3F) cultivated in the Nigeria savannas. The model was calibrated using data from ten field experiments conducted under optimal conditions at two sites (BUK and Dambatta) in Kano in the Sudan savanna (SS) agro-ecology over four growing seasons. Data for model evaluation were obtained from independent experiment for phosphorus (P) response trials conducted under rainfed conditions in two locations (Zaria and Doguwa) in the northern Guinea savanna (NGS) zone. The model calibration and evaluation results indicated good agreement between the simulated and observed values for the measured parameters. This suggests that the CROPGRO-Soybean model was able to accurately predict the performance of soybean in the Nigeria savannas. Results from long-term seasonal analysis showed significant differences among the agro-ecologies, sowing windows and the soybean varieties for grain yield. Higher yields are simulated among the soybean varieties in Zaria in the NGS than in Kano the SS and Jagiri in the southern Guinea savanna (SGS) agro-ecological zones. Sowing from June 1 to July 5 produced optimal yield of TGX1951-3F and TGX1835-10E beyond which yield declined in Kano. In Zaria and Jagiri the simulated results show that, sowing from June 1 to July 12 are appropriate for all the varieties. The variety TGX1951-3F performed better than TGX1904-6F and TGX1835-10E in all the agro-ecologies. The TGX1951-3F is, therefore, recommended for optimum grain yield in the savannas of northern Nigeria. However, the late maturing variety TGX1904-6F is not recommended for the SS due to the short growing season in this zone.

154. Immunoreactivity of humanized single-chain variable fragment against its functional epitope on domain 1 of CD147.

Sci Rep

2022 Apr 25

Intasai N, Rangnoi K, Yamabhai M

155. Characterization of the high-pressure and high-temperature phase diagram and equation of state of chromium.

Sci Rep

2022 Apr 25

Anzellini S, Errandonea D, Burakovsky L

156. TLR4 and SARM1 modulate survival and chemoresistance in an HPV-positive cervical cancer cell line.

Sci Rep

2022 Apr 25

Morale MG, Tamura RE, Cintra R

157. Magnetic chitosan stabilized Cu(II)-tetrazole complex: an effective nanocatalyst for the synthesis of 3-imino-2-phenylisoindolin-1-one derivatives under ultrasound irradiation.

Sci Rep

2022 Apr 25

Nasrollahzadeh M, Shafiei N, Orooji Y.

158. Investigation of optical and electrical properties of novel 4T all perovskite tandem solar cell.

Sci Rep

2022 Apr 25

Moradbeigi M, Razaghi M.

159. Role of Majorana fermions in high-harmonic generation from Kitaev chain.

Sci Rep

2022 Apr 25

Pattanayak A, Pujari S, Dixit G.

160. Effects of ALT-801, a GLP-1 and glucagon receptor dual agonist, in a translational mouse model of non-alcoholic steatohepatitis.

Sci Rep

2022 Apr 23

Nestor JJ, Parkes D, Feigh M

161. Neuroforamen stenosis remains a challenge in conventional computed tomography and new dual-energy techniques.

Sci Rep

2022 Apr 23

Ditges AK, Diekhoff T, Engelhard N

162. Matamatas Chelus spp. (Testudines, Chelidae) have a remarkable evolutionary history of sex chromosomes with a long-term stable XY microchromosome system.

Sci Rep

2022 Apr 23

Viana PF, Feldberg E, Takagui FH

163. Utility of an artificial intelligence system for classification of esophageal lesions when simulating its clinical use.

Sci Rep

2022 Apr 23

Tajiri A, Ishihara R, Kato Y

164. Human amniotic fluid stem cells can alleviate detrusor dysfunction caused by bladder outlet obstruction in rats.

Sci Rep

2022 Apr 23

Liang CC, Huang WC, Shaw SW

165. Causal associations of circulating adiponectin with cardiometabolic diseases and osteoporotic fracture.

Sci Rep

2022 Apr 23

Zhang M(#), Chen X(#), Zhu Y

166. An experimental study on strength improvement of expansive subgrades by polypropylene fibers and geogrid reinforcement.

Sci Rep

2022 Apr 23

Tiwari N, Satyam N.

167. Unemployed individuals contact GPs more frequently but report lower satisfaction: results of the population-based DEGS1 and the GPCare-1 patient survey.

Sci Rep

2022 Apr 23

Ikar N, Sommer S, Schmidt M

168. Renoprotective effects of ferric citrate in a mouse model of chronic kidney disease.

Sci Rep

2022 Apr 23

Hanudel MR, Czaya B, Wong S

169. Periodic attention operates faster during more complex visual search.

Sci Rep

2022 Apr 23

Merholz G, Grabot L, VanRullen R

170. Asteltoxin inhibits extracellular vesicle production through AMPK/mTOR-mediated activation of lysosome function.

Sci Rep

2022 Apr 23

Mitani F(#), Lin J(#), Sakamoto T

171. Selection of oxygen reduction catalysts for secondary tri-electrode zinc-air batteries.

Sci Rep

2022 Apr 23

Loh A, Trudgeon DP, Li X

172. Spatial links between subchondral bone architectural features and cartilage degeneration in osteoarthritic joints.

Sci Rep

2022 Apr 23

Ajami S, Javaheri B, Chang YM

Early diagnosis of osteoarthritis (OA), before the onset of irreversible changes is crucial for understanding the disease process and identifying potential disease-modifying treatments from the earliest stage. OA is a whole joint disease and affects both cartilage and the underlying subchondral bone. However, spatial relationships between cartilage lesion severity (CLS) and microstructural changes in subchondral plate and trabecular bone remain elusive. Herein, we collected femoral heads from hip arthroplasty for primary osteoarthritis (n = 7) and femoral neck fracture (n = 6; non-OA controls) cases. Samples were regionally assessed for cartilage lesions by visual inspection using Outerbridge classification and entire femoral heads were micro-CT scanned. Scans of each femoral head were divided into 4 quadrants followed by morphometric analysis of subchondral plate and trabecular bone in each quadrant. Principal component analysis (PCA), a data reduction method, was employed to assess differences between OA and non-OA samples, and spatial relationship between CLS and subchondral bone changes. Mapping of the trabecular bone microstructure in OA patients with low CLS revealed trabecular organisation resembling non-OA patients, whereas clear differences were identifiable in subchondral plate architecture. The OA-related changes in subchondral plate architecture were summarised in the first principle component (PC1) which correlated with CLS in all quadrants, whilst by comparison such associations in trabecular bone were most prominent in the higher weight-bearing regions of the femoral head. Greater articular cartilage deterioration in OA was regionally-linked with lower BV/TV, TMD and thickness, and greater BS/BV and porosity in the subchondral plate; and with thinner, less separated trabeculae with greater TMD and BS/BV in the trabecular bone. Our findings suggest that impairment of subchondral bone microstructure in early stage of OA is more readily discernible in the cortical plate and that morphological characterisation of the femoral head bone microstructure may allow for earlier OA diagnosis and monitoring of progression.

173. Simultaneous monitoring of the middle cerebral and basilar arteries to detect right-to-left shunts using transcranial Doppler by agitated saline administration.

Sci Rep

2022 Apr 22

Kim M, Park SY, Hong JM.

174. Self-esteem depends on beliefs about the rate of change of social approval.

Sci Rep

2022 Apr 22

Low AAY(#), Hopper WJT(#), Angelescu I

175. 3D isotope density measurements by energy-resolved neutron imaging.

Sci Rep

2022 Apr 22

Losko AS, Vogel SC.

176. FT-IR characteristics, phenolic profiles and inhibitory potential against digestive enzymes of 25 herbal infusions.

Sci Rep

2022 Apr 22

Wongsa P, Phatikulrungsun P, Prathumthong S.

177. Maternal breast milk microbiota and immune markers in relation to subsequent development of celiac disease in offspring.

Sci Rep

2022 Apr 22

Štšepetova J(#), Simre K(#), Tagoma A

178. Determination of key residues in MRGPRX2 to enhance pseudo-allergic reactions induced by fluoroquinolones.

Sci Rep

2022 Apr 22

Hamamura-Yasuno E, Matsushita J, Sato S

179. Investigation of the correlation between immune thrombocytopenia and T cell activity-regulated gene polymorphism using functional study.

Sci Rep

2022 Apr 22

Chen DP, Lin WT, Wen YH

180. The probabilistic pool punishment proportional to the difference of payoff outperforms previous pool and peer punishment.

Sci Rep

2022 Apr 22

Ohdaira T.

181. Influence of hand-arm self-avatar motion delay on the directional perception induced by an illusory sensation of being twisted.

Sci Rep

2022 Apr 22

Amemiya T.

182. Protein-bound sialic acid in saliva contributes directly to salivary anti-influenza virus activity.

Sci Rep

2022 Apr 22

Kobayashi K(#), Shono C(#), Mori T

183. Automated quantitative high-throughput multiplex immunofluorescence pipeline to evaluate OXPHOS defects in formalin-fixed human prostate tissue.

Sci Rep

2022 Apr 22

Sachdeva A, Hart CA, Carey CD

184. Mortality and readmission rates of patients discharged in-hours and out-of-hours from a British ICU over a 3-year period.

Sci Rep

2022 Apr 22

Cumberworth J, Chequers M, Bremner S

185. Surgical Apgar Score and Controlling Nutritional Status Score are significant predictors of major complications after cervical spine surgery.

Sci Rep

2022 Apr 22

Miura K, Koda M, Funayama T

186. Entropy analysis and grey cluster analysis of multiple indexes of 5 kinds of genuine medicinal materials.

Sci Rep

2022 Apr 22

Zhou L, Jiang C, Lin Q.

5 kinds of genuine medicinal materials, including Diding (Latin name: Corydalis bungeana Turcz), Purslane (Latin name: Portulaca oleracea L.), straw sandal board (Latin name: Hoya carnosa (L.f.) R. Br), June snow (Latin name: Serissa japonica (Thunb.) Thunb.), pine vine rattan (Latin name: Lycopodiastrum casuarinoides (Spring) Holub. [Lycopodium casuarinoides Spring]), were selected as the research objects. The combustion heat, thermo gravimetric parameters, and fat content, calcium content, trace element content, ash content of 5 kinds of genuine medicinal materials were measured. The combustion heat, differential thermal gravimetric analysis, fat content, calcium content, trace elements content, and ash content of 5 kinds of genuine medicinal materials were used to build a systematic multi-index evaluation system by gray pattern recognition and grey correlation coefficient cluster analysis, which can make up for the gaps in this area and provide scientific basis and research significance for the study of genuine medicinal materials quality. The results showed that the order of combustion heat of 5 kinds of genuine medicinal materials, including Diding, Purslane, straw sandal board, June snow, pine vine rattan, was Diding > June snow > straw sandal board > Purslane > pine vine rattan, the order of fat content (%) of 5 kinds of genuine medicinal materials was straw sandal board > Diding > pine vine rattan > June snow > Purslane, the order of calcium content (%) was pine vine rattan > June snow > Purslane > straw sandal board > Diding, the order of ash content was June snow > Purslane > straw sandal board > pine vine rattan > Diding. From the analysis of thermogravimetric analysis results and thermogravimetric combustion stability, the order of combustion stability of 5 kinds of genuine medicinal materials was June snow > pine Vine rattan > straw sandal board > Diding > Portulaca oleracea. The order of the content of 12 trace elements in 5 kinds of genuine medicinal materials, in terms of trace element content, June snow contains the highest trace elements in all samples. According to combustion heat, combustibility (combustion stability of genuine medicinal materials), fat, calcium, ash, trace element content, the comprehensive evaluation results of multi-index analysis constructed by gray correlation degree, gray correlation coefficient factor analysis, and gray hierarchical cluster analysis showed that the comprehensive evaluation multi-index order of 5 genuine medicinal materials, including Diding, Purslane, straw sandal board, June snow and pine vine rattan, was June snow > straw sandal board > Diding > Purslane > pine vine rattan. Therefore, the comprehensive evaluation results of the quality of genuine medicinal materials selected in this study were June snow the best, followed by straw sandal board. This research has important theoretical and practical significance for the multi-index measurement and comprehensive evaluation of genuine medicinal materials, and can provide scientific basis and research significance for the research of multi-index quality control of genuine medicinal material.

187. Detrimental health relationship between blood lead and cadmium and the red blood cell folate level.

Sci Rep

2022 Apr 22

Wang BK, Chen WL.

188. Fast environmental sound classification based on resource adaptive convolutional neural network.

Sci Rep

2022 Apr 22

Fang Z, Yin B, Du Z

189. Ferroptosis-related lncRNA signature predicts the prognosis and immune microenvironment of hepatocellular carcinoma.

Sci Rep

2022 Apr 22

Fang C(#), Liu S(#), Feng K

190. Retrospective genomics highlights changes in genetic composition of tiger sharks (Galeocerdo cuvier) and potential loss of a south-eastern Australia population.

Sci Rep

2022 Apr 21

Manuzzi A, Jiménez-Mena B, Henriques R

191. One-step preparation of RGO/Fe(3)O(4)-FeVO(4) nanocomposites as highly effective photocatalysts under natural sunlight illumination.

Sci Rep

2022 Apr 21

Alsulami QA, Rajeh A, Mannaa MA

192. Baicalin regulates autophagy to interfere with small intestinal acute graft-versus-host disease.

Sci Rep

2022 Apr 21

Sun X, Pisano M, Xu L

Acute graft-versus-host disease (aGVHD) is the main complication of and cause of death after allogeneic hematopoietic stem cell transplantation. Baicalin can protect the small intestinal epithelial cells of rats against TNF-α-induced injury and alleviate enteritis-related diarrhea. To verify whether baicalin can protect the small intestinal mucosal barrier by regulating abnormal autophagy and interfering with intestinal aGVHD, a mouse model of aGVHD was established. CB6F1 micewere intravenously injected with a suspension of mononuclear cells derived from BALB/c donor mouse bone marrow and splenic tissue after treatment with 60Co X-rays. After treatment with different doses of baicalin for 15 days, the survival time, serum TNF-α and IL-10 levels, and autophagy markers levels in the intestine were assessed. A cell model of intestinal barrier dysfunction was also used to verify the effect of baicalin. The results showed that baicalin significantly prolonged the survival time, significantly reduced the aGVHD pathology score and clinical score by decreasing the TNF-α level with increasing the IL-10 level compared with the control. Transmission electron microscopy examination showed that baicalin treatment increased the number of autophagic vacuoles and led to the recovery of mitochondrial structures in the intestinal mucosal epithelial cells of mice and in Caco-2 cells. Western blotting results showed that baicalin treatment enhanced autophagy in vivo by regulating the AMPK/mTOR autophagy pathway. Similar results were observed in vitro in Caco-2 cells. Furthermore, the effect of baicalin was reduced after combination treatment with the autophagy inhibitor 3-methyladenine(3-MA). Baicalin can decrease the severity of small intestinal aGVHD by regulating autophagy by influencing imbalances in inflammatory cytokine levels and mucosal barrier damage, thus baicalin may have potential as a new treatment for aGVHD.

193. Early indicators of microbial strain dysbiosis in the human gastrointestinal microbial community of certain healthy humans and hospitalized COVID-19 patients.

Sci Rep

2022 Apr 21

Koo H, Morrow CD.

194. The distribution of manta rays in the western North Atlantic Ocean off the eastern United States.

Sci Rep

2022 Apr 21

Farmer NA, Garrison LP, Horn C

195. Alterations of mucosa-attached microbiome and epithelial cell numbers in the cystic fibrosis small intestine with implications for intestinal disease.

Sci Rep

2022 Apr 21

Kelly J, Al-Rammahi M, Daly K

196. Comparison of vision-related quality of life in patients with homonymous hemianopia and monocular blindness.

Sci Rep

2022 Apr 21

Choi HY, Kim SJ, Kim SY

197. Reliable P wave detection in pathological ECG signals.

Sci Rep

2022 Apr 21

Saclova L, Nemcova A, Smisek R

Accurate automated detection of P waves in ECG allows to provide fast correct diagnosis of various cardiac arrhythmias and select suitable strategy for patients' treatment. However, P waves detection is a still challenging task, especially in long-term ECGs with manifested cardiac pathologies. Software tools used in medical practice usually fail to detect P waves under pathological conditions. Most of recently published approaches have not been tested on such the signals at all. Here we introduce a novel method for accurate and reliable P wave detection, which is success in both normal and pathological cases. Our method uses phasor transform of ECG and innovative decision rules in order to improve P waves detection in pathological signals. The rules are based on a deep knowledge of heart manifestation during various arrhythmias, such as atrial fibrillation, premature ventricular contraction, etc. By involving the rules into the decision process, we are able to find the P wave in the correct location or, alternatively, not to search for it at all. In contrast to another studies, we use three, highly variable annotated ECG databases, which contain both normal and pathological records, to objectively validate our algorithm. The results for physiological records are Se = 98.56% and PP = 99.82% for MIT-BIH Arrhythmia Database (MITDP, with MITDB P-Wave Annotations) and Se = 99.23% and PP = 99.12% for QT database. These results are comparable with other published methods. For pathological signals, the proposed method reaches Se = 96.40% and PP = 91.56% for MITDB and Se = 93.07% and PP = 88.60% for Brno University of Technology ECG Signal Database with Annotations of P wave (BUT PDB). In these signals, the proposed detector greatly outperforms other methods and, thus, represents a huge step towards effective use of fully automated ECG analysis in a real medical practice.

198. Next generation automated traceless cell chromatography platform for GMP-compliant cell isolation and activation.

Sci Rep

2022 Apr 21

Radisch S(#), Poltorak MP(#), Wagner M

199. The influence of contact lenses with different optical designs on the binocular vision and visual behavior of young adults.

Sci Rep

2022 Apr 21

Chen ST(#), Tung HC(#), Chen YT

Theoretically, contact lenses change the accommodation and vergence demands of the eyes and directly or indirectly influence binocular vision. The purpose of this study was to investigate the influence of different optical designs of contact lenses on binocular vision and visual behavior among young adults. In this randomized, single-blinded experimental study, visual behavioral performance (VBP) and Ocular Surface Disease Index questionnaires were used for preliminary screening. Nineteen myopic subjects aged 20-26 years (21.59 ± 1.40 years) participated in the study. Baseline values for subjective refraction and binocular visual functions were evaluated. All the subjects were randomly grouped to wear different optical designs of single-vision, progressive, and bifocal contact lenses. Eye examinations were performed on the first day (CL baseline), 2nd week, and 4th week of wearing the lenses. In addition, subjects completed the VBP and visual quality questionnaire again at the end of the examination. Single-vision contact lenses (Lens 1) increased accommodative lag, negative relative accommodation, and distant and near vergence; however, vergence facilities, accommodative facilities, heterophoria, and the comfort and posture balance dimensions in the VBP questionnaire were improved. Progressive contact lenses (Lens 2) reduced the lag of accommodation and near vergence; in addition, vergence facilities and accommodative facilities were also improved. Bifocal contact lenses (Lens 3) affected negative and positive relative accommodation, but vergence facilities and accommodative facilities also progressed. Furthermore, both progressive (Lens 2) and bifocal (Lens 3) contact lenses enhanced overall visual behavioral performance. In terms of visual quality, single-vision contact lenses (Lens 1) were the most comfortable, progressive and bifocal contact lenses reduced distant visual acuity and stability, progressive contact lenses (Lens 2) had more complaints about halos at night, and bifocal contact lens (Lens 3) users were more likely to have double vision. Compared with single-vision contact lenses, progressive and bifocal contact lenses relaxed accommodation, reduced the lag of accommodation, and improved visual behavioral performance. Although the vergence function showed a significant change, it did not show worse trends when wearing contact lenses. Contact lenses with different optical designs have a great influence on binocular vision and visual behavioral performance.

200. A novel algorithm for cardiovascular screening using conjunctival microcirculatory parameters and blood biomarkers.

Sci Rep

2022 Apr 21

Awuah A, Moore JS, Nesbit MA

201. Changes in neural processing and evaluation of negative facial expressions after administration of an open-label placebo.

Sci Rep

2022 Apr 21

Schienle A, Unger I, Schwab D.

202. eDNA-based detection of the invasive crayfish Pacifastacus leniusculus in streams with a LAMP assay using dependent replicates to gain higher sensitivity.

Sci Rep

2022 Apr 21

Porco D, Hermant S, Purnomo CA

203. Clinical diagnosis of metabolic disorders using untargeted metabolomic profiling and disease-specific networks learned from profiling data.

Sci Rep

2022 Apr 21

Thistlethwaite LR(#), Li X(#), Burrage LC

Untargeted metabolomics is a global molecular profiling technology that can be used to screen for inborn errors of metabolism (IEMs). Metabolite perturbations are evaluated based on current knowledge of specific metabolic pathway deficiencies, a manual diagnostic process that is qualitative, has limited scalability, and is not equipped to learn from accumulating clinical data. Our purpose was to improve upon manual diagnosis of IEMs in the clinic by developing novel computational methods for analyzing untargeted metabolomics data. We employed CTD, an automated computational diagnostic method that "connects the dots" between metabolite perturbations observed in individual metabolomics profiling data and modules identified in disease-specific metabolite co-perturbation networks learned from prior profiling data. We also extended CTD to calculate distances between any two individuals (CTDncd) and between an individual and a disease state (CTDdm), to provide additional network-quantified predictors for use in diagnosis. We show that across 539 plasma samples, CTD-based network-quantified measures can reproduce accurate diagnosis of 16 different IEMs, including adenylosuccinase deficiency, argininemia, argininosuccinic aciduria, aromatic L-amino acid decarboxylase deficiency, cerebral creatine deficiency syndrome type 2, citrullinemia, cobalamin biosynthesis defect, GABA-transaminase deficiency, glutaric acidemia type 1, maple syrup urine disease, methylmalonic aciduria, ornithine transcarbamylase deficiency, phenylketonuria, propionic acidemia, rhizomelic chondrodysplasia punctata, and the Zellweger spectrum disorders. Our approach can be used to supplement information from biochemical pathways and has the potential to significantly enhance the interpretation of variants of uncertain significance uncovered by exome sequencing. CTD, CTDdm, and CTDncd can serve as an essential toolset for biological interpretation of untargeted metabolomics data that overcomes limitations associated with manual diagnosis to assist diagnosticians in clinical decision-making. By automating and quantifying the interpretation of perturbation patterns, CTD can improve the speed and confidence by which clinical laboratory directors make diagnostic and treatment decisions, while automatically improving performance with new case data.

204. Dynamics of maternal gene expression in Rhodnius prolixus.

Sci Rep

2022 Apr 20

Pascual A, Rivera-Pomar R.

205. Higher mortality and intubation rate in COVID-19 patients treated with noninvasive ventilation compared with high-flow oxygen or CPAP.

Sci Rep

2022 Apr 20

Marti S, Carsin AE, Sampol J

206. Transcriptome analysis of umbilical cord mesenchymal stem cells revealed fetal programming due to chorioamnionitis.

Sci Rep

2022 Apr 20

Noguchi Y(#), Taki A(#), Honda I

207. Subthalamic nucleus deep brain stimulation driven by primary motor cortex γ2 activity in parkinsonian monkeys.

Sci Rep

2022 Apr 20

Darbin O, Hatanaka N, Takara S

In parkinsonism, subthalamic nucleus (STN) electrical deep brain stimulation (DBS) improves symptoms, but may be associated with side effects. Adaptive DBS (aDBS), which enables modulation of stimulation, may limit side effects, but limited information is available about clinical effectiveness and efficaciousness. We developed a brain-machine interface for aDBS, which enables modulation of stimulation parameters of STN-DBS in response to γ2 band activity (80-200 Hz) of local field potentials (LFPs) recorded from the primary motor cortex (M1), and tested its effectiveness in parkinsonian monkeys. We trained two monkeys to perform an upper limb reaching task and rendered them parkinsonian with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine. Bipolar intracortical recording electrodes were implanted in the M1, and a recording chamber was attached to access the STN. In aDBS, the M1 LFPs were recorded, filtered into the γ2 band, and discretized into logic pulses by a window discriminator, and the pulses were used to modulate the interval and amplitude of DBS pulses. In constant DBS (cDBS), constant stimulus intervals and amplitudes were used. Reaction and movement times during the task were measured and compared between aDBS and cDBS. The M1-γ2 activities were increased before and during movements in parkinsonian monkeys and these activities modulated the aDBS pulse interval, amplitude, and dispersion. With aDBS and cDBS, reaction and movement times were significantly decreased in comparison to DBS-OFF. The electric charge delivered was lower with aDBS than cDBS. M1-γ2 aDBS in parkinsonian monkeys resulted in clinical benefits that did not exceed those from cDBS. However, M1-γ2 aDBS achieved this magnitude of benefit for only two thirds of the charge delivered by cDBS. In conclusion, M1-γ2 aDBS is an effective therapeutic approach which requires a lower electrical charge delivery than cDBS for comparable clinical benefits.

208. Scientific investigation of a fractional model based on hybrid nanofluids with heat generation and porous medium: applications in the drilling process.

Sci Rep

2022 Apr 20

Khan D, Kumam P, Khan I

209. Human forager response to abrupt climate change at 8.2 ka on the Atlantic coast of Europe.

Sci Rep

2022 Apr 20

García-Escárzaga A, Gutiérrez-Zugasti I, Marín-Arroyo AB

210. Smart-parking management algorithms in smart city.

Sci Rep

2022 Apr 20

Jemmali M, Melhim LKB, Alharbi MT

211. Severe acute kidney disease is associated with worse kidney outcome among acute kidney injury patients.

Sci Rep

2022 Apr 20

Chen YW, Wu MY, Mao CH

212. Development and validation of cost-effective one-step multiplex RT-PCR assay for detecting the SARS-CoV-2 infection using SYBR Green melting curve analysis.

Sci Rep

2022 Apr 20

Sarkar SL(#), Alam ASMRU(#), Das PK(#)

213. Variable-heavy (VH) families influencing IgA1&2 engagement to the antigen, FcαRI and superantigen proteins G, A, and L.

Sci Rep

2022 Apr 20

Ling WL, Su CT, Lua WH

214. Qualitative study identifies life shifts and stress coping strategies in people with multiple sclerosis.

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2022 Apr 20

Lex H, Price P, Clark L.

215. Ultrasound waves in tumors via needle irradiation for precise medicine.

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2022 Apr 20

Cutolo A, Carotenuto AR, Cutolo MA

216. Effectiveness of emotional freedom techniques (EFT) vs sleep hygiene education group therapy (SHE) in management of sleep disorders among elderly.

Sci Rep

2022 Apr 20

Souilm N, Elsakhy NM, Alotaibi YA

Sleep disorders are common among elderly persons, with deleterious effects on their physical and mental health. Many approaches are used to manage such disorders. To compare the Emotional Freedom Techniques-Insomnia (EFT-I) and Sleep Hygiene Education (SHE) group therapy as two treatments for insomnia in a geriatric population when delivered, and their effects on sleep quality, depression, and life satisfaction. This open-label randomized controlled trial study was conducted at El-Abbasia Mental Hospital and Osana family wellness elderly nursing home at Maadi, Cairo. It included 60 elderly patients suffering insomnia sleep problems randomized into two equal groups: one group received a Sleep Hygiene Education (SHE) intervention, the other had a form of Emotional Freedom Techniques (EFT) adapted for use with insomnia (EFT-I). A self-administered questionnaire with tools for sleep quality (Pittsburgh Sleep Quality Index [PSQI]), depression, and life satisfaction was used to collect data. The fieldwork was from January to March 2021. The two groups had equal median age (70 years), and almost similar gender and place of residence distribution. After the intervention, 73.3% of the EFT group had good sleep quality, compared to 100.0% in the SHE group (P = 0.005); the median score of depression (3.00) was higher in the EFT group compared with 0.00 in the SHE group (P < 0.001); as for life satisfaction, the difference was not statistically significant. The multivariate analyses identified the study intervention as the main statistically significant negative predictor of PSQI and depression scores, and a positive predictor of life satisfaction. Being in the SHE group was a negative predictor of PSQI and depression scores. Both SHE and EFT approaches are beneficial for elderly patients' sleep quality, with SHE being more effective in ameliorating sleep. Further replication of this study is needed on a large probability sample from different geographical areas to help for the generalization of the results.

217. Night work, chronotype and cortisol at awakening in female hospital employees.

Sci Rep

2022 Apr 20

Burek K, Rabstein S, Kantermann T

218. Epigenetic and post-transcriptional repression support metabolic suppression in chronically hypoxic goldfish.

Sci Rep

2022 Apr 2

Farhat E, Talarico GGM, Grégoire M

219. A suspension technique for efficient large-scale cancer organoid culturing and perturbation screens.

Sci Rep

2022 Apr 2

Price S, Bhosle S, Gonçalves E

220. Black Kites on a flyway between Western Siberia and the Indian Subcontinent.

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2022 Apr 2

Literák I, Škrábal J, Karyakin IV

The Black Kite (Milvus migrans) is one of the most widespread raptors in the world. The Palaearctic is populated by two migrating subspecies, Milvus migrans migrans and Milvus migrans lineatus, in the western and eastern part of this realm, respectively. There is a large intergradation zone of M. m. migrans/M. m. lineatus in-between. Although the migration routes of M. m. migrans from Europe to Sub-Saharan Africa and the Middle East are well known, detailed information about migration routes of Black Kites from intergradation zone are missing. Using satellite telemetry we are able to fill this gap in our knowledge of these birds. We tagged with GPS/SMS/GPRS telemetry loggers 13 and 6 Black Kite pulli in lowland around Biysk (Altai Krai, Russia) and in mountains around Kosh-Agach (Altai Republic, Russia), respectively. After fledging, Black Kites from both subpopulations stayed in a small, non-overlapping areas and then migrated to southern Asia through narrow corridors. Black Kites originating from Biysk migrated through the Western Circum-Himalayan Corridor. Black Kites originating from Kosh-Agach used the Trans-Himalayan Corridor crossing the Himalayas in altitudes of up to 6256 m asl. The average total distance travelled of Black Kites from both subpopulations was 9166 km without any significant differences between these subpopulations. Timing of both spring and autumn migration did not vary along different age groups. Black Kites from both subpopulations wintered in low elevations of Pakistan and India. Birds wintered on average for 190 days, and the mean area of individual home ranges in winter was 4704 km2. During the breeding period, birds dwelled in south-western Siberia, where they spent on average 125 days with an average home range size 3537 km2. We found that ontogenetic shifts in migratory behaviour of Black Kites from Eastern Russia differ from those in population/subspecies in Europe. Black Kites crossing the Himalayas fly and, moreover, stay for hours resting at night in the environment of mountains at altitudes over 5000 m.

221. Potential cannabidiol (CBD) repurposing as antibacterial and promising therapy of CBD plus polymyxin B (PB) against PB-resistant gram-negative bacilli.

Sci Rep

2022 Apr 19

Abichabki N, Zacharias LV(#), Moreira NC(#)

222. A novel 2-phase residual U-net algorithm combined with optimal mass transportation for 3D brain tumor detection and segmentation.

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2022 Apr 19

Lin WW, Lin JW, Huang TM

223. Atrial fibrillation designation with micro-Raman spectroscopy and scanning acoustic microscope.

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2022 Apr 19

Parlatan U, Parlatan S, Sen K

224. The effects of embodying wildlife in virtual reality on conservation behaviors.

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2022 Apr 19

Pimentel D, Kalyanaraman S.

225. Collisional positron acoustic soliton and double layer in an unmagnetized plasma having multi-species.

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2022 Apr 19

Akter S, Hafez MG.

226. Biodegradable cellulose nanocrystals hydrogels for removal of acid red 8 dye from aqueous solutions.

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2022 Apr 19

Abdelaziz RM, El-Maghraby A, Sadik WA

227. Assessment of heterogeneous Head Start treatment effects on cognitive and social-emotional outcomes.

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2022 Apr 19

Lee SY, Kim R, Rodgers J

228. Factors influencing wind turbine avoidance behaviour of a migrating soaring bird.

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2022 Apr 19

Santos CD(#), Ramesh H(#), Ferraz R

229. A multi-parameter persistence framework for mathematical morphology.

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2022 Apr 19

Chung YM, Day S, Hu CS.

230. Comprehensive analysis of epigenetics regulation, prognostic and the correlation with immune infiltrates of GPX7 in adult gliomas.

Sci Rep

2022 Apr 19

Ferreira WAS, Vitiello GAF, da Silva Medina T

Gliomas are the most commonly occurring malignant brain tumor characterized by an immunosuppressive microenvironment accompanied by profound epigenetic changes, thus influencing the prognosis. Glutathione peroxidase 7 (GPX7) is essential for regulating reactive oxygen species homeostasis under oxidative stress. However, little is known about the function of GPX7 in gliomas. In this study, we hypothesized that GPX7 methylation status could influence biological functions and local immune responses that ultimately impact prognosis in adult gliomas. We conducted an integrated bioinformatics analysis mining GPX7 DNA methylation status, transcriptional and survival data of glioma patients. We discovered that GPX7 was remarkably increased in glioma tissues and cell lines, and was associated with poor prognosis. This upregulation was significantly linked to clinicopathological and molecular features, besides being expressed in a cell cycle-dependent manner. Our results consistently demonstrated that upregulation of GPX7 is tightly modulated by epigenetic processes, which also impacted the overall survival of patients with low-grade gliomas (LGG). Based on the analysis of biological functions, we found that GPX7 might be involved in immune mechanisms involving both innate and adaptive immunity, type I interferon production and regulation of synaptic transmission in LGG, whereas in GBM, it is mainly related to metabolic regulation of mitochondrial dynamics. We also found that GPX7 strongly correlates with immune cell infiltration and diverse immune cell markers, suggesting its role in tumor-specific immune response and in regulating the migration of immune cell types to the tumor microenvironment. Combining these multiple data, we provided the first evidence regarding the epigenetic-mediated regulatory mechanisms underlying GPX7 activation in gliomas. Furthermore, our study brings key insights into the significant effect of GPX7 in modulating both immune molecules and in immune cell infiltration in the microenvironment of gliomas, which might impact the patient outcome, opening up future opportunities to regulate the local immune response.

231. The association between hypomagnesemia and poor glycaemic control in type 1 diabetes is limited to insulin resistant individuals.

Sci Rep

2022 Apr 19

Oost LJ, van Heck JIP, Tack CJ

In a cohort of adults with type 1 diabetes, we examined the prevalence of hypomagnesemia and the correlation of serum magnesium levels with metabolic determinants, such as glycaemic control (as HbA1c), inflammatory markers and circulating cytokines. Furthermore, we assessed if a surrogate for insulin resistance is essential for the possible association of serum magnesium with metabolic determinants. Individuals with type 1 diabetes, aged above 18 years, were included and clinical characteristics were obtained from questionnaires and clinical records. In venous blood samples we measured cytokines and adipose-tissue specific secretion proteins. Serum magnesium concentrations were measured and correlated with clinical data and laboratory measurements using univariate and multivariate regression models. Hierarchical multiple regression of serum magnesium with insulin resistance was adjusted for diabetes and potential magnesium confounders. The prevalence of hypomagnesemia (serum magnesium levels < 0.7 mmol/L) was 2.9% in a cohort consisting of 241 individuals with type 1 diabetes. The magnesium concentration in the cohort was not associated with HbA1c (r = - 0.12, P-value = 0.068) nor with any inflammatory marker or adipokine. However, insulin dose (IU/kg), a surrogate measure of resistance in type 1 diabetes, moderated the association of serum magnesium (mmol/L) with HbA1c (mmol/mol) with a B coefficient of - 71.91 (95% CI: - 119.11; -24.71), P-value = 0.003) and Log10 high-sensitivity C-reactive protein (Log10 mg/L) - 2.09 (95% CI: - 3.70; - 0.48), P-value = 0.011). The association of low serum magnesium levels with glycaemic control (HbA1c) and high-sensitivity C-reactive protein in individuals with type 1 diabetes is limited to subjects using a high insulin dose and suggests that insulin resistance, a type 2 diabetes feature, is a prerequisite for hypomagnesemia.

232. Cationic vacancies as defects in honeycomb lattices with modular symmetries.

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2022 Apr 19

Kanyolo GM, Masese T.

233. Lipid composition of the Amazonian 'Mountain Sacha Inchis' including Plukenetia carolis-vegae Bussmann, Paniagua & C.Téllez.

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2022 Apr 19

Kodahl N, Frandsen HB, Lütken H

234. Molar loss induces hypothalamic and hippocampal astrogliosis in aged mice.

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2022 Apr 18

Furukawa M, Tada H, Wang J

235. Inosine triphosphate pyrophosphatase from Trypanosoma brucei cleanses cytosolic pools from deaminated nucleotides.

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2022 Apr 18

Vidal AE, Yagüe-Capilla M, Martínez-Arribas B

236. Anti-blastocystosis activity of antioxidant coated ZIF-8 combined with mesoporous silicas MCM-41 and KIT-6.

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2022 Apr 17

Jermy BR, Al-Jindan RY, Ravinayagam V

The biocompatible hybrid Zeolitic imidazolate framework-8 (ZIF-8)/structured silica nanocomposite can be loaded with antioxidants such as curcumin and resveratrol to offer multiple advantages of drug functionalization and structural stability. blastocystosis, an enteric parasite, has various outcomes and its treatment includes drugs which have side effects and do not result in a full cure. We aimed to design novel biocompatible nanocomposites containing natural antioxidant, resveratrol or curcumin and ZIF-8/mesoporous silica. We also assessed their anti-blastocystosis activities as bioactive novel nanocomposites. The nano-silica (MCM-41 and KIT-6) was synthesized using a hydrothermal technique and made composite with ZIF-8 using an ultrasonic technique. The antioxidants, curcumin and resveratrol, were loaded over ZIF-8/MCM-41 and ZIF-8/KIT-6 using a rotary evaporator technique to form novel nanocomposites with bioactive properties. The formulated nanocomposites were characterized. To test their biological activity, suspension of cultured blastocystosis cysts (subtype 3) were exposed to increasing concentrations of nanocomposites and the minimal lethal concentration of each nanocomposite was calculated. The bioactive nanocomposites (ZIF-8/KIT-6, ZIF-8/KIT-6/Resveratrol and ZIF-8/MCM-41/Curcumin) were formulated. Anti-blastocystosis activity of the tested nanocomposites was both dose and time dependent. ZIF-8/KIT-6/Resveratol showed the maximum percentage of growth inhibition (~ 100%) at a concentration of 500 µg/ml after 5 h of exposure. More than 90% of blastocystosis cysts' growth was significantly inhibited at all concentrations of ZIF-8/MCM-41/Curcumin, with different times of exposure, while it occurred only at the highest concentration of ZIF-8/KIT-6 (800 µg/ml). Using cheap, simple, reproducible and scalable techniques, we nano-formulated innovative bioactive nanocomposites, by incorporating the bioactive ZIF-8 (Zn2+ with imidazole), structured mesosilica and natural antioxidant compounds, curcumin or resveratrol, to generate multifunctional modalities. These eco-friendly, naturally based, safe, economical, biocompatible, and bioavailable nanocomposites are potential nanotherapeutics. The anti-blastocystosis results of these three nanocomposites indicate their potentially promising innovative and safe use as alternative Blastocystosis therapies.

237. Babesiosis in cattle and ixodid tick distribution in Dasenech and Salamago Districts, southern Ethiopia.

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2022 Apr 16

Fesseha H, Mathewos M, Eshetu E

Babesiosis, caused by protozoan parasites of the genus Babesia, and ixodid ticks are considered to be one of the most important causes that result in significant economic losses in cattle production worldwide, including in Ethiopia. A cross-sectional study was undertaken in the Dasenech and Salamago Districts of South Omo zone Ethiopia to determine the prevalence and associated risk factors of babesia infection and ixodid ticks of cattle using Giemsa-stained thin and thick film techniques and morphological identification keys for babesia species and tick identification, respectively. Out of 470 examined cattle, 102 (21.7%) were infected by Babesiosis (15.53% Babesia bigemina and 6.17% Babesia bovis). A statistically significant association (p < 0.05) was observed between babesia infection and season and tick infestation. However, cattle that were infected with the Babesia parasite revealed a lower mean PCV value (21.49%) than noninfected cattle (28.29%) and showed a statistically significant (p < 0.05) difference with the occurrence of Babesia infection. The overall prevalence of ixodid ticks was 53.8% (253/470) and revealed a statistically significant association (p < 0.05) between the season and origin of the animal. However, no statistically significant association (p > 0.05) was observed between sex, age, and body condition score of the animal with the occurrence of ixodid tick. A total of 8040 adult ticks belonging to four tick genera, Amblyomma, Rhipicephalus (Boophilus), Hyalomma, and Rhipicephalus, were collected from various body parts and identified. The high prevalence of Babesia infection and ixodid ticks in cattle at the study sites requires seroprevalence and molecular studies to identify the predominant Babesia species and to detect Babesia in tick hemolymph for the identification of tick genera responsible for the occurrence of Babesia infection. Additionally, tailoring suitable and coordinated tick management methods using chemotherapy as well as strategic treatment to overt clinical cases of bovine babesiosis is critical.

238. Investigating the dispersal of macro- and microplastics on agricultural fields 30 years after sewage sludge application.

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2022 Apr 16

Weber CJ, Santowski A, Chifflard P.

239. Error rate reduction of single-qubit gates via noise-aware decomposition into native gates.

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2022 Apr 16

Maldonado TJ, Flick J, Krastanov S

240. Texture evolution during processing and post-processing of maraging steel fabricated by laser powder bed fusion.

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2022 Apr 16

Kannan R, Nandwana P.

241. Agavin induces beneficial microbes in the shrimp microbiota under farming conditions.

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2022 Apr 16

Ochoa-Romo JP, Cornejo-Granados F, Lopez-Zavala AA

Prebiotics and probiotics have shown a number of beneficial impacts preventing diseases in cultured shrimps. Complex soluble carbohydrates are considered ideal for fostering microbiota biodiversity by fermentable oligosaccharides, disaccharides, monosaccharides, and polyols (FODMAPS). Here we evaluated the growth performance and microbiota composition of the white shrimp Litopenaeus vannamei after dietary intervention using agavin as a FODMAP prebiotic under farming conditions. Adult L. vannamei were raised at a shrimp farm and the effect of agavin supplemented at 2% (AG2) or 10% (AG10) levels were compared to an agavin-free basal diet (BD). After 28 days-trial, the feed conversion ratio, total feed ingested, and protein efficiency ratio was significantly improved on animals fed with AG2. At the same time, no effect on growth performance was observed in AG10. Surprisingly, after sequencing the V3-V4 regions of the 16S rRNA gene a higher microbial richness and diversity in the hepatopancreas and intestine was found only in those animals receiving the AG10 diet, while those receiving the AG2 diet had a decreased richness and diversity, both diets compared to the BD. The beta diversity analysis showed a clear significant microbiota clustering by agavin diets only in the hepatopancreas, suggesting that agavin supplementation had a more substantial deterministic effect on the microbiota of hepatopancreas than on the intestine. We analyzed the literature to search beneficial microbes for shrimp's health and found sequences for 42 species in our 16S data, being significantly increased Lactobacillus pentosus, Pseudomonas putida and Pseudomonas synxantha in the hepatopancreas of the AG10 and Rodopseudomonas palustris and Streptococcus thermophiles th1435 in the hepatopancreas of the AG2, both compared to BD. Interestingly, when we analyzed the abundance of 42 beneficial microbes as a single microbial community "meta-community," found an increase in their abundance as agavin concentration increases in the hepatopancreas. In addition, we also sequenced the DNA of agavin and found 9 of the 42 beneficial microbes. From those, Lactobacillus lactis and Lactobacillus delbrueckii were found in shrimps fed with agavin (both AG2 and AG10), and Lysinibacillus fusiformis in AG10 and they were absent the BD diet, suggesting these three species could be introduced with the agavin to the diet. Our work provides evidence that agavin supplementation is associated with an increase of beneficial microbes for the shrimp microbiota at farming conditions. Our study provides the first evidence that a shrimp prebiotic may selectively modify the microbiota in an organ-dependent effect.

242. An exploration of new methods for metabolic syndrome examination by infrared thermography and knowledge mining.

Sci Rep

2022 Apr 16

Mi BH(#), Zhang WZ(#), Xiao YH

Metabolic syndrome (MS) is a clinical syndrome with multiple metabolic disorders. As the diagnostic criteria for MS still lacking of imaging laboratory method, this study aimed to explore the differences between healthy people and MS patients through infrared thermography (IRT). However, the observation region of the IRT image is uncertain, and the research tried to solve this problem with the help of knowledge mining technology. 43 MS participants were randomly included through a cross-sectional method, and 43 healthy participants were recruited through number matching. The IRT image of each participant was segmented into the region of interest (ROI) through the preprocessing method proposed in this research, and then the ROI features were granulated by the K-means algorithm to generate the formal background, and finally, the two formal background were separately built into a knowledge graph through the knowledge mining method based on the attribute partial order structure. The baseline data shows that there is no difference in age, gender, and height between the two groups (P > 0.05). The image preprocessing method can segment the IRT image into 18 ROI. Through the K-means method, each group of data can be separately established with a 43 × 36 formal background and generated a knowledge graph. It can be found through knowledge mining and independent-samples T test that the average temperature and maximum temperature difference between the chest and face of the two groups are statistically different (P < 0.01). IRT could reflect the difference between healthy people and MS people. The measurement regions were found by the method of knowledge mining on the premise of unknown. The method proposed in this paper may add a new imaging method for MS laboratory examinations, and at the same time, through knowledge mining, it can also expand a new idea for clinical research of IRT.

243. Observational study of rebiopsy in EGFR-TKI-resistant patients with EGFR mutation-positive advanced NSCLC.

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2022 Apr 16

Koyama K, Miura S, Watanabe S

244. Deep 3D attention CLSTM U-Net based automated liver segmentation and volumetry for the liver transplantation in abdominal CT volumes.

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2022 Apr 16

Jeong JG(#), Choi S(#), Kim YJ

245. Unity yield of deterministically positioned quantum dot single photon sources.

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2022 Apr 16

Laferrière P, Yeung E, Miron I

246. The coral reef-dwelling Peneroplis spp. shows calcification recovery to ocean acidification conditions.

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2022 Apr 16

Charrieau LM, Nagai Y, Kimoto K

247. Time dependent analysis of rat microglial surface markers in traumatic brain injury reveals dynamics of distinct cell subpopulations.

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2022 Apr 15

Gottlieb A, Toledano-Furman N, Prabhakara KS

248. Dual role of melatonin as an anti-colitis and anti-extra intestinal alterations against acetic acid-induced colitis model in rats.

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2022 Apr 15

Ahmed O, Farid A, Elamir A.

249. Biochemical changes and macrophage polarization of a silane-based endodontic irrigant in an animal model.

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2022 Apr 15

Daood U, Ilyas MS, Ashraf M

250. Deep learning model for tongue cancer diagnosis using endoscopic images.

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2022 Apr 15

Heo J, Lim JH, Lee HR

251. Aberrant functional connectivity and temporal variability of the dynamic pain connectome in patients with low back related leg pain.

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2022 Apr 15

Pei Y, Peng J, Zhang Y

252. Piezo1 activation using Yoda1 inhibits macropinocytosis in A431 human epidermoid carcinoma cells.

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2022 Apr 15

Kuriyama M(#), Hirose H(#), Masuda T

253. The role of epiphytes in seagrass productivity under ocean acidification.

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2022 Apr 15

Berlinghof J, Peiffer F, Marzocchi U

254. Seasonal and sexual variation in mRNA expression of selected adipokine genes affecting fat deposition and metabolism of the emu (Dromaius novaehollandiae).

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2022 Apr 15

Kim JE, Bennett DC, Wright K

255. An integrated expert weight determination method for design concept evaluation.

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2022 Apr 15

Chen Z, Zhong P, Liu M

256. A systematic review and meta-analysis of the association between uric acid levels and chronic kidney disease.

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2022 Apr 15

Gonçalves DLN, Moreira TR, da Silva LS.

257. Rationale and performances of a data-driven method for computing the duration of pharmacological prescriptions using secondary data sources.

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2022 Apr 15

Pazzagli L, Liang D, Andersen M

258. Transcriptome analysis reveals anthocyanin regulation in Chinese cabbage (Brassica rapa L.) at low temperatures.

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2022 Apr 15

Dai Y(#), Zhang L(#), Sun X

259. Efficient double-layer sintering of titanomagnetite concentrate.

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2022 Apr 15

Xu L, Liu H, Cheng D

260. Blindfolded adults use mental transformation strategies for spatial scaling of tactile maps.

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2022 Apr 15

Szubielska M, Möhring W.

261. An activation specific anti-Mac-1 designed ankyrin repeat protein improves survival in a mouse model of acute lung injury.

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2022 Apr 15

Siegel PM(#), Przewosnik AS, Wrobel J

262. Loss of microbiota-derived protective metabolites after neutropenic fever.

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2022 Apr 15

Rashidi A, Ebadi M, Rehman TU

263. Thermo-mechanical properties of 3D printed photocurable shape memory resin for clear aligners.

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2022 Apr 15

Lee SY(#), Kim H(#), Kim HJ

264. The impact of maternal influences on childhood obesity.

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2022 Apr 15

Hsu PC, Hwang FM, Chien MI

265. Misfolding-induced chronic pancreatitis in CPA1 N256K mutant mice is unaffected by global deletion of Ddit3/Chop.

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2022 Apr 15

Németh BC(#), Demcsák A(#), Geisz A

266. Decoding personalized motor cortical excitability states from human electroencephalography.

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2022 Apr 15

Hussain SJ, Quentin R.

267. Valorization of spent disposable wooden chopstick as the CO(2) adsorbent for a CO(2)/H(2) mixed gas purification.

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2022 Apr 15

Koo-Amornpattana W, Jonglertjunya W, Phadungbut P

268. Signal voids of active cardiac implants at 3.0 T CMR.

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2022 Apr 15

Reiter T, Weiss I, Weber OM

269. Development of a paper printed colorimetric sensor based on Cu-Curcumin nanoparticles for evolving point-of-care clinical diagnosis of sodium.

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2022 Apr 15

Chandran N, Janardhanan P, Bayal M

270. Machine learning models for prediction of adverse events after percutaneous coronary intervention.

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2022 Apr 15

Niimi N, Shiraishi Y, Sawano M

271. Non-invasive sampling of water-borne hormones demonstrates individual consistency of the cortisol response to stress in laboratory zebrafish (Danio rerio).

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2022 Apr 15

Midttun HLE, Øverli Ø, Tudorache C

272. Cross subkey side channel analysis based on small samples.

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2022 Apr 15

Hu F, Wang H, Wang J.

273. Key connection between gravitational instability in physical gels and granular media.

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2022 Apr 15

Kobayashi KU, Kurita R.

274. Culture and multiomic analysis of lung cancer patient-derived pleural effusions revealed distinct druggable molecular types.

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2022 Apr 15

Seo HY(#), Kim SC(#), Roh WL

275. Understanding of cell death induced by the constituents of Taxus yunnanensis wood.

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2022 Apr 15

Akao Y, Terazawa R, Sugito N

276. Radiation dose-rate is a neglected critical parameter in dose-response of insects.

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2022 Apr 14

Yamada H, Dias VS, Parker AG

277. Inactivation of various variant types of SARS-CoV-2 by indoor-light-sensitive TiO(2)-based photocatalyst.

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2022 Apr 14

Nakano R, Yamaguchi A, Sunada K

278. Computational prediction of the molecular mechanism of statin group of drugs against SARS-CoV-2 pathogenesis.

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2022 Apr 14

Ghosh D(#), Ghosh Dastidar D(#), Roy K(#)

279. Predictors of impaired SARS-CoV-2 immunity in healthcare workers after vaccination with BNT162b2.

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2022 Apr 14

Bertram S, Blazquez-Navarro A, Seidel M

280. Smoking has disruptive effects on the small bowel luminal microbiome.

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2022 Apr 14

Leite G, Barlow GM, Hosseini A

281. Genome-wide interaction analysis of menopausal hormone therapy use and breast cancer risk among 62,370 women.

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2022 Apr 13

Wang X, Kapoor PM, Auer PL

282. Impact of temperature, inoculum flow pattern, inoculum type, and their ratio on dry anaerobic digestion for biogas production.

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2022 Apr 13

Hossain MS, Karim TU, Onik MH

283. Impaired surface marker expression in stimulated Epstein-Barr virus transformed lymphoblasts from Barth Syndrome patients.

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2022 Apr 13

Zegallai HM, Hatch GM.

284. Identification of additional dye tracers for measuring solid food intake and food preference via consumption-excretion in Drosophila.

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2022 Apr 13

Shell BC, Grotewiel M.

285. The relationship between stability of interpersonal coordination and inter-brain EEG synchronization during anti-phase tapping.

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2022 Apr 13

Kurihara Y, Takahashi T, Osu R.

286. Functionalized graphene oxide nanosheets with folic acid and silk fibroin as a novel nanobiocomposite for biomedical applications.

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2022 Apr 13

Eivazzadeh-Keihan R, Alimirzaloo F, Aghamirza Moghim Aliabadi H

287. The appropriate and sequential value of standard radiograph, computed tomography and magnetic resonance imaging to characterize a bone tumor.

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2022 Apr 13

Gaume M, Chevret S, Campagna R

288. Antioxidant potential and essential oil properties of Hypericum perforatum L. assessed by application of selenite and nano-selenium.

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2022 Apr 13

Nazari MR, Abdossi V, Hargalani FZ

289. Amplification of elliptically polarized sub-femtosecond pulses in neon-like X-ray laser modulated by an IR field.

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2022 Apr 13

Khairulin IR, Antonov VA, Ryabikin MY

290. Negative affective burden is associated with higher resting-state functional connectivity in subjective cognitive decline.

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2022 Apr 13

Schwarz C(#), Benson GS(#), Antonenko D

291. Instability motion characteristics of overburden rock and the distribution pattern of fissures in shallow thick seam mining.

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2022 Apr 13

Li J, Liu C, Guo X

292. Circuit network theory of n-horizontal bridge structure.

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2022 Apr 13

Fang XY, Tan ZZ.

293. An optimal selection method of wells for secondary fracturing in a single coal seam and its application.

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2022 Apr 12

Tan X, Ni X, Li Z

294. Design of an ultra-wideband omnidirectional and polarization insensitive flower petal antenna for potential ambient electromagnetic energy harvesting applications.

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2022 Apr 12

Wang WC, Garu P.

295. Unique evidence of fluid alteration in the Kakowa (L6) ordinary chondrite.

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2022 Apr 12

Baziotis IP, Ma C, Guan Y

296. Non-destructive crystallinity assessment of indomethacin in tablets made from smartFilms(®) using terahertz time-domain spectroscopy.

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2022 Apr 12

Ornik J, Heidrich L, Schesny R

297. Enhanced in situ H(2)O(2) production explains synergy between an LPMO with a cellulose-binding domain and a single-domain LPMO.

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2022 Apr 12

Stepnov AA, Eijsink VGH, Forsberg Z.

298. Polarization based discrete variables quantum key distribution via conjugated homodyne detection.

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2022 Apr 12

Ramos MF(#), Pinto AN, Silva NA(#).

299. Longitudinal in-vivo quantification of tumour microvascular heterogeneity by optical coherence angiography in pre-clinical radiation therapy.

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2022 Apr 12

Allam N, Jeffrey Zabel W, Demidov V

300. Association of bleb formation with peri-aneurysmal contact in unruptured intracranial aneurysms.

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2022 Apr 12

Satoh T(#), Yagi T(#), Sawada Y

301. Real world data of anticoagulant treatment in non-valvular atrial fibrillation across renal function status.

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2022 Apr 12

Calderon JM, Martinez F, Fernandez A

302. Exploring cellulose nanocrystals obtained from olive tree wastes as sustainable crop protection tool against bacterial diseases.

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2022 Apr 12

Schiavi D, Francesconi S, Taddei AR

303. An influence of dew point temperature on the occurrence of Mycobacterium tuberculosis disease in Chennai, India.

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2022 Apr 12

Krishnan R, Thiruvengadam K, Jayabal L

304. Experimental evolution of active Brownian grains driven by quantum effects in superfluid helium.

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2022 Apr 12

Petrov OF, Boltnev RE, Vasiliev MM.

305. Medical image segmentation model based on triple gate MultiLayer perceptron.

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2022 Apr 12

Yan J, Wang X(#), Cai J

To alleviate the social contradiction between limited medical resources and increasing medical needs, the medical image-assisted diagnosis based on deep learning has become the research focus in Wise Information Technology of med. Most of the existing medical segmentation models based on Convolution or Transformer have achieved relatively sound effects. However, the Convolution-based model with a limited receptive field cannot establish long-distance dependencies between features as the Network deepens. The Transformer-based model produces large computation overhead and cannot generalize the bias of local features and perceive the position feature of medical images, which are essential in medical image segmentation. To address those issues, we present Triple Gate MultiLayer Perceptron U-Net (TGMLP U-Net), a medical image segmentation model based on MLP, in which we design the Triple Gate MultiLayer Perceptron (TGMLP), composed of three parts. Firstly, considering encoding the position information of features, we propose the Triple MLP module based on MultiLayer Perceptron in this model. It uses linear projection to encode features from the high, wide, and channel dimensions, enabling the model to capture the long-distance dependence of features along the spatial dimension and the precise position information of features in three dimensions with less computational overhead. Then, we design the Local Priors and Global Perceptron module. The Global Perceptron divides the feature map into different partitions and conducts correlation modelling for each partition to establish the global dependency between partitions. The Local Priors uses multi-scale Convolution with high local feature extraction ability to explore further the relationship of context feature information within the structure. At last, we suggest a Gate-controlled Mechanism to effectively solves the problem that the dependence of position embeddings between Patches and within Patches in medical images cannot be well learned due to the relatively small number of samples in medical images segmentation data. Experimental results indicate that the proposed model outperforms other state-of-the-art models in most evaluation indicators, demonstrating its excellent performance in segmenting medical images.

306. Cross-border malaria drivers and risk factors on the Brazil-Venezuela border between 2016 and 2018.

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2022 Apr 11

Wangdi K(#), Wetzler E(#), Marchesini P

Globally, cross-border importation of malaria has become a challenge to malaria elimination. The border areas between Brazil and Venezuela have experienced high numbers of imported cases due to increased population movement and migration out of Venezuela. This study aimed to identify risk factors for imported malaria and delineate imported malaria hotspots in Roraima, Brazil and Bolivar, Venezuela between 2016 and 2018. Data on malaria surveillance cases from Roraima, Brazil and Bolivar, Venezuela from 2016 to 2018 were obtained from national surveillance systems: the Brazilian Malaria Epidemiology Surveillance Information System (SIVEP-Malaria), the Venezuelan Ministry of Health and other non-government organizations. A multivariable logistic regression model was used to identify the risk factors for imported malaria. Spatial autocorrelation in malaria incidence was explored using Getis-Ord (Gi*) statistics. During the study period, there were 11,270 (24.3%) and 4072 (0.7%) imported malaria cases in Roraima, Brazil and Bolivar, Venezuela, respectively. In the multivariable logistic regression for Roraima, men were 28% less likely to be an imported case compared to women (Adjusted Odds Ratio [AOR] = 0.72; 95% confidence interval [CI] 0.665, 0.781). Ages 20-29 and 30-39 were 90% (AOR = 1.90; 95% CI 1.649, 2.181) and 54% (AOR = 1.54; 95% CI 1.331, 1.782) more likely to be an imported case compared to the 0-9 year age group, respectively. Imported cases were 197 times (AOR = 197.03; 95% CI 175.094, 221.712) more likely to occur in miners than those working in agriculture and domestic work. In Bolivar, cases aged 10-19 (AOR = 1.75; 95% CI 1.389, 2.192), 20-29 (AOR = 2.48; 95% CI 1.957, 3.144), and 30-39 (AOR = 2.29; 95% CI 1.803, 2.913) were at higher risk of being an imported case than those in the 0-9 year old group, with older age groups having a slightly higher risk compared to Roraima. Compared to agriculture and domestic workers, tourism, timber and fishing workers (AOR = 6.38; 95% CI 4.393, 9.254) and miners (AOR = 7.03; 95% CI 4.903, 10.092) were between six and seven times more likely to be an imported case. Spatial analysis showed the risk was higher along the international border in the municipalities of Roraima, Brazil. To achieve malaria elimination, cross-border populations in the hotspot municipalities will need targeted intervention strategies tailored to occupation, age and mobility status. Furthermore, all stakeholders, including implementers, policymakers, and donors, should support and explore the introduction of novel approaches to address these hard-to-reach populations with the most cost-effective interventions.

307. Genetic structure in neotropical birds with different tolerance to urbanization.

Sci Rep

2022 Apr 11

Rodríguez-Bardía M, Fuchs EJ, Barrantes G

308. Clustering of Parkinson subtypes reveals strong influence of DRD2 polymorphism and gender.

Sci Rep

2022 Apr 11

Pelzer EA(#), Stürmer S(#), Feis DL

309. Longitudinal [(18)]UCB-H/[(18)F]FDG imaging depicts complex patterns of structural and functional neuroplasticity following bilateral vestibular loss in the rat.

Sci Rep

2022 Apr 11

Antons M, Lindner M, Grosch M

310. Dispositional gratitude, health-related factors, and lipid profiles in midlife: a biomarker study.

Sci Rep

2022 Apr 11

Hartanto A, Majeed NM, Lua VYQ

311. Tuneable conductivity at extreme electric fields in ZnO tetrapod-silicone composites for high-voltage power cable insulation.

Sci Rep

2022 Apr 11

Greijer H, Mirotta N, Treossi E

312. Biological activities and phenolic compounds of olive oil mill wastewater from Abani, endemic Algerian variety.

Sci Rep

2022 Apr 11

Gueboudji Z, Addad D, Kadi K

313. Learning-based cable coupling effect modeling for robotic manipulation of heavy industrial cables.

Sci Rep

2022 Apr 11

Mou F, Wang B, Wu D.

314. A multi-omics approach to elucidate the mechanisms of action of a dietary muramidase administered to broiler chickens.

Sci Rep

2022 Apr 1

Brugaletta G, De Cesare A, Laghi L

315. A comparison of international and national references to measure the prevalence of stunting in Pakistani school-age girls.

Sci Rep

2022 Apr 1

Qaisar R, Karim A.

316. Metformin is associated with favorable outcomes in patients with COVID-19 and type 2 diabetes mellitus.

Sci Rep

2022 Apr 1

Ma Z, Patel N, Vemparala P

317. Molecular mechanisms of Huanglian jiedu decoction on ulcerative colitis based on network pharmacology and molecular docking.

Sci Rep

2022 Apr 1

Yang J(#), Tang C(#), Jin R(#)

318. XGB-DrugPred: computational prediction of druggable proteins using eXtreme gradient boosting and optimized features set.

Sci Rep

2022 Apr 1

Sikander R, Ghulam A, Ali F.

319. Effect of SARs-CoV-2 pandemic on infection prevention behaviors and bacterial burden of high touch surfaces in a medical/surgical setting.

Sci Rep

2022 Apr 1

Resendiz M, Blanchard DM, Lustik MB

This study aimed to determine the longitudinal efficacy of ultraviolet germicidal disinfection (UV-C) in a non-terminal disinfection context. Moreover, factors influencing enhanced infection prevention behaviors during the SARS-CoV-2 pandemic were evaluated. Sixty nursing staff from three medical/surgical wards in a large military hospital were recruited for a survey and microbiological sampling of high-touch surfaces (stethoscope, personal electronic device, common access card, and hospital ID badge) and portable medical equipment (wheelchairs and mobile commodes). Surveys included hand hygiene estimates, frequency/method of cleaning items of interest, perception of UV-C, and factors influencing the use of enhanced disinfection tools. Surveys and microbiological samples were performed prior to and after the installation of a rapid, automated ultraviolet disinfection enclosure for staff use. Both time points preceded the SARS-CoV-2 pandemic in the United States. A final survey/sampling time point was carried out eight months after the declaration of the COVID-19 pandemic. Participants' hand hygiene frequency did not increase throughout the study, with > 80% reporting a minimum of 4 hand hygiene events per patient hour. The cleaning frequency of high-touch surfaces (non-clinical) but not portable medical equipment increased after installation of a UV-C disinfection tool and was sustained eight months into the COVID-19 pandemic. While a modest decrease in bacterial burden was observed after UV-C intervention, a more significant reduction was observed across all surfaces during pandemic time sampling, though no detectable decrease in pathogenic contamination was observed at either time point. Motivators of UV-C use included fear of SARS-CoV-2 contamination and transmission, ease of device use, and access to rapid, automated disinfection tools while deterrents reported included technical concerns, lack of time, and preference for other disinfection methods. Automated, rapid-cycle UV-C disinfection can be efficacious for high-touch surfaces not currently governed by infection prevention and control guidelines. The introduction of enhanced disinfection tools like UV-C can enhance the overall cleaning frequency and is correlated with mild decreases in bacterial burden of high-touch surfaces, this is enhanced during periods of heightened infection threat. Evidence from this study offers insights into the factors which prompt healthcare workers to internalize/dismiss enhanced infection prevention procedures.

320. Influence of the autotaxin-lysophosphatidic acid axis on cellular function and cytokine expression in different breast cancer cell lines.

Sci Rep

2022 Apr 1

Hauck T, Kadam S, Heinz K

321. Magnetic UiO-66 functionalized with 4,4'-diamino-2,2'-stilbenedisulfonic as a highly recoverable acid catalyst for the synthesis of 4H-chromenes in green solvent.

Sci Rep

2022 Apr 1

Khodabakhshi MR, Baghersad MH.

322. Strain-resolved analysis in a randomized trial of antibiotic pretreatment and maintenance dose delivery mode with fecal microbiota transplant for ulcerative colitis.

Sci Rep

2022 Apr 1

Smith BJ, Piceno Y, Zydek M

323. Longitudinal relationship of liver injury with inflammation biomarkers in COVID-19 hospitalized patients using a joint modeling approach.

Sci Rep

2022 Apr 1

Diaz-Louzao C, Barrera-Lopez L, Lopez-Rodriguez M

324. A deep learning model (FociRad) for automated detection of γ-H2AX foci and radiation dose estimation.

Sci Rep

2022 Apr 1

Wanotayan R, Chousangsuntorn K, Petisiwaveth P

325. Ceramides and phospholipids in plasma extracellular vesicles are associated with high risk of major cardiovascular events after carotid endarterectomy.

Sci Rep

2022 Apr 1

Timmerman N(#), Waissi F(#), Dekker M

Ceramides and phosphatidylcholines (PCs) are bioactive lipids and lipid bilayer membrane components. Distinct ceramides/PCs (ratios) predict cardiovascular outcome in patients with coronary artery disease. Extracellular vesicles (EVs) are proposed biomarkers for cardiovascular disease and contain ceramides/PCs. Ceramides/PCs have not been studied in patients undergoing carotid endarterectomy (CEA) nor in EVs. We therefore investigated whether levels of ceramides/PCs in plasma and EVs are associated with postoperative risk of major adverse cardiovascular events (MACE) following CEA. In 873 patients undergoing CEA of the Athero-Express biobank, we quantitatively measured seven ceramides/PCs in preoperative blood samples: Cer(d18:1/16:0), Cer(d18:1/18:0), Cer(d18:1/24:0), Cer(d18:1/24:1), PC(14:0/22:6), PC(16:0/16:0) and PC(16:0/22:5) in plasma and two plasma EV-subfractions (LDL and TEX). We analyzed the association of ceramides, PCs and their predefined ratios with the three-year postoperative risk of MACE (including stroke, myocardial infarction and cardiovascular death). A total of 138 patients (16%) developed MACE during the three-year follow-up. In the LDL-EV subfraction, higher levels of Cer(d18:1/24:1) and Cer(d18:1/16:0)/PC(16:0/22:5) ratio were significantly associated with an increased risk of MACE (adjusted HR per SD [95% CI] 1.24 [1.01-1.53] and 1.26 [1.04-1.52], respectively). In the TEX-EV subfraction, three ratios Cer(d18:1/16:0)/Cer(d18:1/24:0), Cer(d18:1/18:0)/Cer(d18:1/24:0) and Cer(d18:1/24:1)/Cer(d18:1/24:0) were positively associated with MACE (adjusted HR per SD 1.34 [1.06-1.70], 1.24 [1.01-1.51] and 1.31 [1.08-1.58], respectively). In conclusion, distinct ceramides and PCs in plasma EVs determined in preoperative blood were independently associated with an increased 3-year risk of MACE after CEA. These lipids are therefore potential markers to identify high-risk CEA patients qualifying for secondary preventive add-on therapy.

326. Structural basis to repurpose boron-based proteasome inhibitors Bortezomib and Ixazomib as β-lactamase inhibitors.

Sci Rep

2022 Apr 1

Perbandt M(#), Werner N(#), Prester A

327. Characterization of an engineered mucus microenvironment for in vitro modeling of host-microbe interactions.

Sci Rep

2022 Apr 1

Huang AJ, O'Brien CL, Dawe N

328. Improved calibration of electrochemical aptamer-based sensors.

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2022 Apr 1

Downs AM, Gerson J, Leung KK

329. Rapid surface uplift and crustal flow in the Central Andes (southern Peru) controlled by lithospheric drip dynamics.

Sci Rep

2022 Apr 1

Göğüş OH, Sundell K, Uluocak EŞ

Newmer生物

Newmer生物