生信网-文献期刊

Sci Rep

2021 May 7

Clift CL, Su YR, Bichell D

2. Incorporating false negative tests in epidemiological models for SARS-CoV-2 transmission and reconciling with seroprevalence estimates.

Sci Rep

2021 May 7

Bhattacharyya R, Kundu R, Bhaduri R

3. Characterizing the impact of MnO(2) addition on the efficiency of Fe(0)/H(2)O systems.

Sci Rep

2021 May 7

Cao V, Alyoussef G, Gatcha-Bandjun N

4. Temporal structure of brain oscillations predicts learned nocebo responses to pain.

Sci Rep

2021 May 7

Thomaidou MA(#), Blythe JS(#), Houtman SJ(#)

5. A systematic review and meta-analysis of regional risk factors for critical outcomes of COVID-19 during early phase of the pandemic.

Sci Rep

2021 May 7

Kim HJ(#), Hwang H(#), Hong H

6. Angiotensin converting enzyme 2 is a novel target of the γ-secretase complex.

Sci Rep

2021 May 7

Bartolomé A, Liang J, Wang P

7. Effects of methane ratio on MPDF (micro-pilot dual-fuel) combustion characteristic in a heavy-duty single cylinder engine.

Sci Rep

2021 May 7

Choi M, Mohiuddin K, Park S.

In this study, the characteristics of micro-pilot dual-fuel combustion with respect to the fuel mixture ratio in a single cylinder dual-fuel engine have been investigated. In order to analyze the characteristics of micro-pilot dual-fuel combustion, a metal engine and an optical single cylinder dual-fuel engine were used. The fuel mixture ratio was varied for experimental purposes; the diesel was directly injected into combustion chamber and the methane gas was supplied via intake port. The present study reports that increasing the methane mixture ratio from 0 to 97.67% changes the diesel combustion to pre-mixed combustion. As a result, the peak cylinder pressure was increased from 184 to 198 bar, and the rate of heat release was greatly advanced. In the MPDF condition, the nitrogen oxides emissions were reduced by about 90%p, and the fuel conversion efficiency increased about 5%p because of the low combustion temperature of pre-mixed combustion. However, for the same reason, the hydrocarbon emissions were increased about 95%p. The fastest combustion speed was found form the results of methane mixture ratio between 40 and 80%. In the condition of diesel combustion and micro-pilot dual-fuel combustion, the combustion periods of middle and initial were increased, respectively, resulting in the low combustion speed. The standard deviation of peak cylinder pressure, which represents the combustion variation, was correlated with initial combustion period. While the condition of methane gas mixture ratio between 40 and 80% shows the lowest combustion variation, the highest combustion variation was occurred by MPDF condition. Through the optical engine experiment, it can be found that the cycle to cycle combustion variation is ascribed to the turbulent flow and the variation of ignition position. The combustion images show that the unpredictable characteristics of the ignition position and slow flame propagation speed caused the combustion variation in micro-pilot dual-fuel combustion.

8. Low human dystrophin levels prevent cardiac electrophysiological and structural remodelling in a Duchenne mouse model.

Sci Rep

2021 May 7

Marchal GA, van Putten M, Verkerk AO

9. Evaluation of the performance and gas emissions of a tractor diesel engine using blended fuel diesel and biodiesel to determine the best loading stages.

Sci Rep

2021 May 7

Emaish H, Abualnaja KM, Kandil EE

Fossil fuels are the main energy sources responsible for harmful emissions and global warming. Using biodiesel made from waste deep-frying oil as an alternative fuel source in diesel engines has drawn great attention. This biodiesel is produced using the transesterification process and blends with mineral diesel at Faculty of Agriculture Saba Basha, Alexandria University, Egypt. The turbocharged diesel engine of a Kubota M-90 tractor was tested. The objectives of this work are to test tractor as a source of power in the farm using waste deep-frying oil biodiesel to utilize waste frying oils (WFO) in clean energy production on the farm and determine the best engine loading stages to maximize engine efficiencies for different fuel blends and reduce the environmental impact of gas emissions from tractor diesel engines in the farms. The experiment design was factorial, with two factors, where the first was the engine load (0%, 25%, 50%, 75%, and 100%) and the second was fuel blend (0%, 5%, 20%, and 100% biodiesel), and the effects of loading stages and biodiesel percentage on engine performance indicators of engine speed, power take off torque, power take off power, brake power, brake mean effective pressure, brake thermal efficiency, brake specific fuel consumption, and gas emissions were studied. The experimental results indicated that engine load percentage and fuel blend percentage significantly affected all studied characters, and the best engine loading stages were between 25 and 75% to maximize engine efficiency and minimize the specific fuel consumption and gas emissions. Increasing the biodiesel percentage at all loading stages resulted decreasing in Engine brake power (BP), brake thermal efficiency, Power take-off (PTO) torque, and brake mean effective pressure and increases in brake specific fuel consumption. Increasing the engine load resulted in decreases in O2 emissions and increases in CO2, CO, NO, and SO2 emissions. Increasing the biodiesel percentage in the blended fuel samples resulted in increases in O2 and NO emissions and decreases in CO2, CO, and SO2 emissions. The use of biodiesel with diesel fuel reduces the environmental impact of gas emissions and decreases engine efficiency.

10. Tracking the time course of reproduction number and lockdown's effect on human behaviour during SARS-CoV-2 epidemic: nonparametric estimation.

Sci Rep

2021 May 7

Pillonetto G, Bisiacco M, Palù G

Understanding the SARS-CoV-2 dynamics has been subject of intense research in the last months. In particular, accurate modeling of lockdown effects on human behaviour and epidemic evolution is a key issue in order e.g. to inform health-care decisions on emergency management. In this regard, the compartmental and spatial models so far proposed use parametric descriptions of the contact rate, often assuming a time-invariant effect of the lockdown. In this paper we show that these assumptions may lead to erroneous evaluations on the ongoing pandemic. Thus, we develop a new class of nonparametric compartmental models able to describe how the impact of the lockdown varies in time. Our estimation strategy does not require significant Bayes prior information and exploits regularization theory. Hospitalized data are mapped into an infinite-dimensional space, hence obtaining a function which takes into account also how social distancing measures and people's growing awareness of infection's risk evolves as time progresses. This also permits to reconstruct a continuous-time profile of SARS-CoV-2 reproduction number with a resolution never reached before in the literature. When applied to data collected in Lombardy, the most affected Italian region, our model illustrates how people behaviour changed during the restrictions and its importance to contain the epidemic. Results also indicate that, at the end of the lockdown, around [Formula: see text] of people in Lombardy and [Formula: see text] in Italy was affected by SARS-CoV-2, with the fatality rate being 1.14%. Then, we discuss how the situation evolved after the end of the lockdown showing that the reproduction number dangerously increased in the summer, due to holiday relax, reaching values larger than one on August 1, 2020. Finally, we also document how Italy faced the second wave of infection in the last part of 2020. Since several countries still observe a growing epidemic and others could be subject to other waves, the proposed reproduction number tracking methodology can be of great help to health care authorities to prevent SARS-CoV-2 diffusion or to assess the impact of lockdown restrictions on human behaviour to contain the spread.

11. Structural insight into Pichia pastoris fatty acid synthase.

Sci Rep

2021 May 7

Snowden JS, Alzahrani J, Sherry L

12. A combined microfluidic deep learning approach for lung cancer cell high throughput screening toward automatic cancer screening applications.

Sci Rep

2021 May 7

Hashemzadeh H(#), Shojaeilangari S(#), Allahverdi A

13. Characteristics of soil salt crust formed by mixing calcium chloride with sodium sulfate and the possibility of inhibiting wind-sand flow.

Sci Rep

2021 May 7

Li S, Li C, Fu X.

14. Multi-channel transorbital electrical stimulation for effective stimulation of posterior retina.

Sci Rep

2021 May 7

Lee S, Park J, Kwon J

15. The modulation of neural insular activity by a brain computer interface differentially affects pain discrimination.

Sci Rep

2021 May 7

Taesler P, Rose M.

16. Prevalence and risk factors of anxiety and depression among the community-dwelling elderly in Nay Pyi Taw Union Territory, Myanmar.

Sci Rep

2021 May 7

Cho SM, Saw YM, Saw TN

17. In vivo cell proliferation analysis and cell-tracing reveal the global cellular dynamics of periodontal ligament cells under mechanical-loading.

Sci Rep

2021 May 7

Mizukoshi M, Kaku M, Thant L

18. Multiple social network influences can generate unexpected environmental outcomes.

Sci Rep

2021 May 7

Yletyinen J, Perry GLW, Stahlmann-Brown P

19. Effects of TiO(2) structure and Co addition as a second metal on Ru-based catalysts supported on TiO(2) for selective hydrogenation of furfural to FA.

Sci Rep

2021 May 7

Tolek W, Nanthasanti N, Pongthawornsakun B

20. Neuroticism is positively associated with leptin/adiponectin ratio, leptin and IL-6 in young adults.

Sci Rep

2021 May 7

Syk M, Isaksson J, Rasmusson AJ

21. Endothelial glycocalyx degradation and disease severity in Plasmodium vivax and Plasmodium knowlesi malaria.

Sci Rep

2021 May 7

Barber BE, Grigg MJ, Piera KA

22. Determination and dietary risk assessment of 284 pesticide residues in local fruit cultivars in Shanghai, China.

Sci Rep

2021 May 6

Zhang Y, Si W, Chen L

23. An individual alginate lyase is effective in the disruption of Laminaria digitata recalcitrant cell wall.

Sci Rep

2021 May 6

Costa M, Pio L, Bule P

24. Inspection of the lens thickness with preoperative biometric measurements prevents an erroneous interpretation of posterior capsule during FLACS.

Sci Rep

2021 May 6

Kurosawa M, Horiguchi H, Shiba T

25. Variations of risk factors for ischemic stroke and its subtypes in Chinese patients in Taiwan.

Sci Rep

2021 May 6

Tsai CF, Sudlow CLM, Anderson N

26. Thawed cryopreserved synovial mesenchymal stem cells show comparable effects to cultured cells in the inhibition of osteoarthritis progression in rats.

Sci Rep

2021 May 6

Horiuchi K, Ozeki N, Endo K

27. Longitudinal studies support the safety and ethics of virtual reality suicide as a research method.

Sci Rep

2021 May 6

Huang X, Funsch KM, Park EC

28. Hospitalization for acute coronary syndrome increases the long-term risk of pneumonia: a population-based cohort study.

Sci Rep

2021 May 6

Kim J, Park SJ, Choi S

29. Seroprevalence of SARS-CoV-2 IgG antibodies and risk factors in health care workers at an academic medical center in Boston, Massachusetts.

Sci Rep

2021 May 6

Kataria Y, Cole M, Duffy E

30. Deep learning methods allow fully automated segmentation of metacarpal bones to quantify volumetric bone mineral density.

Sci Rep

2021 May 6

Folle L, Meinderink T, Simon D

31. Hybrid bilayer membranes on metallurgical polished aluminum.

Sci Rep

2021 May 6

Sabirovas T, Valiūnienė A, Valincius G.

32. A community-based randomized controlled trial providing weekly iron-folic acid supplementation increased serum- ferritin, -folate and hemoglobin concentration of adolescent girls in southern Ethiopia.

Sci Rep

2021 May 6

Handiso YH, Belachew T, Abuye C

33. Identification of germ cell-specific Mga variant mRNA that promotes meiosis via impediment of a non-canonical PRC1.

Sci Rep

2021 May 6

Kitamura Y, Uranishi K, Hirasaki M

34. pH induced conformational alteration in human peroxiredoxin 6 might be responsible for its resistance against lysosomal pH or high temperature.

Sci Rep

2021 May 6

Chowhan RK, Hotumalani S, Rahaman H

35. Steroid hormone bioavailability is controlled by the lymphatic system.

Sci Rep

2021 May 6

Klossner R, Groessl M, Schumacher N

36. Suppression of neuropathic pain and comorbidities by recurrent cycles of repetitive transcranial direct current motor cortex stimulation in mice.

Sci Rep

2021 May 6

Gan Z(#), Li H(#), Naser PV

37. Interplay between IL6 and CRIM1 in thiopurine intolerance due to hematological toxicity in leukemic patients with wild-type NUDT15 and TPMT.

Sci Rep

2021 May 6

Kim H(#), You S(#), Park Y

38. Association between ACE2 and TMPRSS2 nasopharyngeal expression and COVID-19 respiratory distress.

Sci Rep

2021 May 6

Rossi ÁD, de Araújo JLF, de Almeida TB

39. Studies of the potential of a native natural biosorbent for the elimination of an anionic textile dye Cibacron Blue in aqueous solution.

Sci Rep

2021 May 6

Grabi H, Derridj F, Lemlikchi W

40. A biomimetic peptide has no effect on the isotopic fractionation during in vitro silica precipitation.

Sci Rep

2021 May 6

Cassarino L, Curnow P(#), Hendry KR(#).

41. Clinical characteristics of tumor lysis syndrome in childhood acute lymphoblastic leukemia.

Sci Rep

2021 May 6

Xue Y(#), Chen J(#), Gao S

42. New identification and significance of Early Cretaceous mafic rocks in the interior South China Block.

Sci Rep

2021 May 31

Su HM, Jiang SY, Shao JB

43. A novel introgression line collection to unravel the genetics of climacteric ripening and fruit quality in melon.

Sci Rep

2021 May 31

Pereira L(#), Santo Domingo M(#), Argyris J

44. Trends in the prevalence of adult overweight and obesity in Australia, and its association with geographic remoteness.

Sci Rep

2021 May 31

Keramat SA, Alam K, Al-Hanawi MK

The prevalence of overweight and obesity has been increasing globally and has become a significant public health concern in Australia in the two past decades. This study explores the most recent national prevalence and trends of adult overweight and obesity in Australia. It will also investigate geographic remoteness as a potential risk factor for an individual being overweight or obese in adulthood. A retrospective longitudinal study that utilised 14 successive waves (wave 6 through 19) of a nationally representative linked individual-level survey. Data was obtained from the Household, Income and Labour Dynamics in Australia survey. The data on 199,675 observations from 26,713 individuals aged ≥ 15 years over the period 2006 to 2019 was analysed. Random-effects logit model was employed to estimate the association between geographic remoteness and the risk of excessive weight gain. The results reveal that the prevalence of overweight, obesity and combined overweight and obesity among Australian adults in 2019 were 34%, 26% and 60%, respectively. The analysis shows that the prevalence of overweight and obesity varies by geographic remoteness. Adults from regional city urban (OR 1.53, 95% CI 1.16-2.03) and rural areas (OR 1.32, 95% CI 1.18-1.47) were more likely to be obese compared with their counterparts from major city urban areas. The results also show that adults living in major city urban areas, regional city urban areas, and regional city rural areas in Australia were 1.53 (OR 1.53, 95% CI 1.16-2.03), 1.32 (OR 1.32, 95% CI 1.18-1.47), and 1.18 (OR 1.18, 95% CI 1.08-1.29) times more likely to be overweight compared with their counterparts from major city urban areas in Australia. Substantial geographic variation in the prevalence of overweight and obesity exists among Australian adults and appears to be increasing. Public health measures should focus on contextual obesogenic factors and behavioural characteristics to curb the rising prevalence of adult obesity.

45. Role of cytoplasmic localization of maspin in promoting cell invasion in breast cancer with aggressive phenotype.

Sci Rep

2021 May 31

Sakabe T, Wakahara M, Shiota G

Sci Rep

2021 May 31

Jin Q(#), Su H(#), Yang R(#)

47. A genetic variant in telomerase reverse transcriptase (TERT) modifies cancer risk in Lynch syndrome patients harbouring pathogenic MSH2 variants.

Sci Rep

2021 May 31

Wiik MU, Evans TJ, Belhadj S

48. Neural networks for increased accuracy of allergenic pollen monitoring.

Sci Rep

2021 May 31

Polling M(#), Li C(#), Cao L

49. Genome-wide identification of the BASS gene family in four Gossypium species and functional characterization of GhBASSs against salt stress.

Sci Rep

2021 May 31

Myo T(#), Wei F(#), Zhang H

50. Disruption of the odorant coreceptor Orco impairs foraging and host finding behaviors in the New World screwworm fly.

Sci Rep

2021 May 31

Paulo DF, Junqueira ACM, Arp AP

51. An ERP study on facial emotion processing in young people with subjective memory complaints.

Sci Rep

2021 May 31

Perez V, Garrido-Chaves R, Perez-Alarcón M

52. A randomized controlled trial of two diets enriched with protein or fat in patients with type 2 diabetes treated with dapagliflozin.

Sci Rep

2021 May 31

Watanabe Y, Suzuki D, Kuribayashi N

53. An optogenetic method for investigating presynaptic molecular regulation.

Sci Rep

2021 May 31

Kay Y, Herring BE.

54. Freeze-thaw characterization process to minimize aggregation and enable drug product manufacturing of protein based therapeutics.

Sci Rep

2021 May 31

Jain K, Salamat-Miller N, Taylor K.

55. Re-crushing process and non-Darcian seepage characteristics of broken coal medium in coal mine water inrush.

Sci Rep

2021 May 31

Pang M, Zhang T, Guo Y

56. Abscisic acid implicated in differential plant responses of Phaseolus vulgaris during endophytic colonization by Metarhizium and pathogenic colonization by Fusarium.

Sci Rep

2021 May 31

Hu S, Bidochka MJ.

57. Platelet derived growth factor receptor β (PDGFRβ) is a host receptor for the human malaria parasite adhesin TRAP.

Sci Rep

2021 May 31

Steel RWJ(#), Vigdorovich V(#), Dambrauskas N

58. Fluorescent base analogues in gapmers enable stealth labeling of antisense oligonucleotide therapeutics.

Sci Rep

2021 May 31

Nilsson JR, Baladi T, Gallud A

59. Electromechanical impedance based self-diagnosis of piezoelectric smart structure using principal component analysis and LibSVM.

Sci Rep

2021 May 31

Jiang X, Zhang X, Tang T

60. A three-dimensional musculoskeletal model of the dog.

Sci Rep

2021 May 31

Stark H, Fischer MS, Hunt A

61. Longitudinal effects of meditation on brain resting-state functional connectivity.

Sci Rep

2021 May 31

Zhang Z, Luh WM, Duan W

62. Magnetic and structural properties of the solid solution CuAl(2(1-x))Ga(2x)O(4).

Sci Rep

2021 May 31

Bullard TJ, Susner MA, Taddei KM

63. Environmental influences on sinking rates and distributions of transparent exopolymer particles after a typhoon surge at the Western Pacific.

Sci Rep

2021 May 31

Islam MS, Sun J, Zhang G

64. Facet controlled growth mechanism of SnO(2) (101) nanosheet assembled film via cold crystallization.

Sci Rep

2021 May 28

Masuda Y.

65. Transcriptome analysis of MBD5-associated neurodevelopmental disorder (MAND) neural progenitor cells reveals dysregulation of autism-associated genes.

Sci Rep

2021 May 28

Mullegama SV, Klein SD, Williams SR

66. Identification and functional analysis of cadmium-binding protein in the visceral mass of Crassostrea gigas.

Sci Rep

2021 May 28

Zheng Z(#), Kawakami K(#), Zhang D

67. Berberine modulates hyper-inflammation in mouse macrophages stimulated with polyinosinic-polycytidylic acid via calcium-CHOP/STAT pathway.

Sci Rep

2021 May 28

Kim HJ, Kim YJ, Park W.

68. Accurate detection and quantification of seasonal abundance of American bullfrog (Lithobates catesbeianus) using ddPCR eDNA assays.

Sci Rep

2021 May 28

Everts T, Halfmaerten D, Neyrinck S

The invasive American bullfrog (Lithobates catesbeianus) imperils freshwater biodiversity worldwide. Effective management hinges on early detection of incipient invasions and subsequent rapid response, as established populations are extremely difficult to eradicate. Although environmental DNA (eDNA) detection methods provide a highly sensitive alternative to conventional surveillance techniques, extensive testing is imperative to generate reliable output. Here, we tested and compared the performance of two primer/probe assays to detect and quantify the abundance of bullfrogs in Western Europe in silico and in situ using digital droplet PCR (ddPCR). Although both assays proved to be equally target-specific and sensitive, one outperformed the other in ddPCR detection resolution (i.e., distinguishing groups of target-positive and target-negative droplets), and hence was selected for further analyses. Mesocosm experiments revealed that tadpole abundance and biomass explained 99% of the variation in eDNA concentration. Because per individual eDNA emission rates did not differ significantly among tadpoles and juveniles, and adults mostly reside out of the water, eDNA concentration can be used as an approximation of local bullfrog abundance in natural populations. Seasonal eDNA patterns in three colonized ponds showed parallel fluctuations in bullfrog eDNA concentration. An increase in eDNA concentration was detected in spring, followed by a strong peak coinciding with the breeding season (August, September or October), and continuously low eDNA concentrations during winter. With this study, we report the validation process required for appropriately implementing eDNA barcoding analyses in lentic systems. We demonstrate that this technique can serve as a solid and reliable tool to detect the early stages of bullfrog invasions and to quantify temporal changes in abundance that will be useful in coordinating large-scale bullfrog eradication programs and evaluating their efficiency.

69. Aging affects artemisinin synthesis in Artemisia annua.

Sci Rep

2021 May 28

Li J, Chu XH, Wang XY

70. A Japanese traditional medicine Hochuekkito promotes negative conversion of vancomycin-resistant Enterococci.

Sci Rep

2021 May 28

Kohno J, Kawamura T, Kikuchi A

71. Fungal diversity driven by bark features affects phorophyte preference in epiphytic orchids from southern China.

Sci Rep

2021 May 28

Pecoraro L, Rasmussen HN, Gomes SIF

72. Trace compounds in Early Medieval Egyptian blue carry information on provenance, manufacture, application, and ageing.

Sci Rep

2021 May 28

Dariz P(#), Schmid T(#).

73. Impact of a tropical forest blowdown on aboveground carbon balance.

Sci Rep

2021 May 28

Cushman KC, Burley JT, Imbach B

74. Deep learning of material transport in complex neurite networks.

Sci Rep

2021 May 28

Li A, Barati Farimani A, Zhang YJ.

75. Retrospective methodology to estimate daily infections from deaths (REMEDID) in COVID-19: the Spain case study.

Sci Rep

2021 May 28

García-García D, Vigo MI, Fonfría ES

76. A single serving of mixed spices alters gut microflora composition: a dose-response randomised trial.

Sci Rep

2021 May 28

Khine WWT(#), Haldar S(#), De Loi S

77. The intestinal microbiota contributes to the growth and physiological state of muscle tissue in piglets.

Sci Rep

2021 May 27

Qi R(#), Sun J(#), Qiu X

78. Magneto-optical design of anomalous Nernst thermopile.

Sci Rep

2021 May 27

Wang J, Miura A, Modak R

79. Subclinical gait disturbance and postoperative gait improvement in patients with degenerative cervical myelopathy.

Sci Rep

2021 May 27

Lee DH, Yoo JY, Cho JH

80. Correlation between amide proton transfer-related signal intensity and diffusion and perfusion magnetic resonance imaging parameters in high-grade glioma.

Sci Rep

2021 May 27

Nakajo M(#), Bohara M(#), Kamimura K

81. Gene expression and morphological responses of Lolium perenne L. exposed to cadmium (Cd(2+)) and mercury (Hg(2+)).

Sci Rep

2021 May 27

Cruz Y, Villar S, Gutiérrez K

82. First theoretical determination of relative biological effectiveness of very high energy electrons.

Sci Rep

2021 May 27

Delorme R, Masilela TAM, Etoh C

83. Association between stress and bilateral symmetrical alopecia in free-ranging Formosan macaques in Mt. Longevity, Taiwan.

Sci Rep

2021 May 27

Chen CC, Chang AM, Tsai MS

Since 2013, a high incidence of bilateral symmetrical alopecia has been observed in free-ranging Formosan macaques (Macaca cyclopis) in Mt. Longevity, Taiwan. We hypothesized that stress induces alopecia in this population. To verify our hypothesis, we evaluated the histopathological characteristics of skin biopsy and used a validated enzyme immunoassay (EIA) for fecal glucocorticoid metabolite (FGM) analysis, which act as an indicator of stress experienced by the individual. Follicular densities were lower (2.1-3.0 mm2) in individuals with symmetrical alopecia than in those with normal hair conditions (4.7 mm2). Furthermore, anagen to catagen/telogen ratios were lower in individuals with alopecia (0-1.4) than in those with normal hair (4.0). The histopathological characteristics of alopecia were similar to those of telogen effluvium, which indicates that stress is one of the possible etiologies. On the basis of the analytical and biological validation of EIAs for FGM analysis, 11β-hydroxyetiocholanolone was considered suitable for monitoring adrenocortical activity in both sexes of Formosan macaques. The mean concentrations (standard error; sample size) of 11β-hydroxyetiocholanolone were 2.02 (0.17; n = 10) and 1.41 (0.10; n = 31) μg/g for individuals with and without alopecia, respectively. Furthermore, the results of logistic regression analysis show that 11β-hydroxyetiocholanolone (p = 0.012) concentration was positively associated with alopecia. Thus, stress was the most likely to trigger symmetrical alopecia in Formosan macaques in Mt. Longevity. Although stress can decrease the fitness of an individual, considering the population status of Formosan macaques in Taiwan is stable and alopecia was only observed in our study area, which is isolated from other populations, the impact on the total population of Formosan macaque in Taiwan is limited. Nonetheless, stress-induced immunosuppression and alopecia might affect the local abundance and increase zoonosis risk due to frequent human-macaque contact in Mt. Longevity. Future studies are suggested to focus on the causative factor of stress and the effects of stress and alopecia on the health and welfare in the Formosan macaques.

84. Dietary and Plasmodium challenge effects on the cuticular hydrocarbon profile of Anopheles albimanus.

Sci Rep

2021 May 27

Claudio-Piedras F, Recio-Tótoro B, Cime-Castillo J

85. Draft genome sequence of the pulse crop blackgram [Vigna mungo (L.) Hepper] reveals potential R-genes.

Sci Rep

2021 May 27

Jegadeesan S, Raizada A, Dhanasekar P

86. Metabolomic analysis of skeletal muscle before and after strenuous exercise to fatigue.

Sci Rep

2021 May 27

Ohmura H, Mukai K, Takahashi Y

87. Inferring long-distance connectivity shaped by air-mass movement for improved experimental design in aerobiology.

Sci Rep

2021 May 27

Choufany M, Martinetti D, Soubeyrand S

88. Screening and selection of camptothecin producing endophytes from Nothapodytes nimmoniana.

Sci Rep

2021 May 27

Mohinudeen IAHK, Pandey S, Kanniyappan H

89. Saline-alkaline stress in growing maize seedlings is alleviated by Trichoderma asperellum through regulation of the soil environment.

Sci Rep

2021 May 27

Fu J, Xiao Y, Wang YF

90. Potential local adaptation of corals at acidified and warmed Nikko Bay, Palau.

Sci Rep

2021 May 27

Kurihara H, Watanabe A, Tsugi A

91. The importance of the urinary output criterion for the detection and prognostic meaning of AKI.

Sci Rep

2021 May 27

Vanmassenhove J(#), Steen J(#), Vansteelandt S

92. Hydrochemistry of sediment pore water in the Bratsk reservoir (Baikal region, Russia).

Sci Rep

2021 May 27

Poletaeva VI, Tirskikh EN, Pastukhov MV.

93. Mobile sonouroflowmetry using voiding sound and volume.

Sci Rep

2021 May 27

El Helou E, Naba J, Youssef K

94. Dynamic modulation of social influence by indirect reciprocity.

Sci Rep

2021 May 27

Zonca J, Folsø A, Sciutti A.

95. Calcification in free-living coralline algae is strongly influenced by morphology: Implications for susceptibility to ocean acidification.

Sci Rep

2021 May 27

Schubert N, Hofmann LC, Almeida Saá AC

96. Change in rheotactic behavior patterns of dinoflagellates in response to different microfluidic environments.

Sci Rep

2021 May 27

Li SW, Lin PH, Ho TY

97. Automatic detect lung node with deep learning in segmentation and imbalance data labeling.

Sci Rep

2021 May 27

Chiu TW, Tsai YL, Su SF.

98. Comparison of different anesthesia modalities during percutaneous kyphoplasty of osteoporotic vertebral compression fractures.

Sci Rep

2021 May 27

Ge C(#), Wu X(#), Gao Z(#)

99. A plant endophyte Staphylococcus hominis strain MBL_AB63 produces a novel lantibiotic, homicorcin and a position one variant.

Sci Rep

2021 May 27

Aftab Uddin M(#), Akter S(#), Ferdous M

100. White-tailed deer S96 prion protein does not support stable in vitro propagation of most common CWD strains.

Sci Rep

2021 May 27

Otero A, Duque Velásquez C, Aiken J

101. Chemical analysis and computed tomography of metallic inclusions in Roman glass to unveil ancient coloring methods.

Sci Rep

2021 May 27

Di Turo F, Moro G, Artesani A

102. Microplastic in angling baits as a cryptic source of contamination in European freshwaters.

Sci Rep

2021 May 27

de Carvalho AR, Imbert A, Parker B

103. Urine biomarkers for the prediction of mortality in COVID-19 hospitalized patients.

Sci Rep

2021 May 27

Morell-Garcia D, Ramos-Chavarino D, Bauça JM

104. Magnetic properties of (Bi(1-x)La(x))(Fe,Co)O(3) films fabricated by a pulsed DC reactive sputtering and demonstration of magnetization reversal by electric field.

Sci Rep

2021 May 27

Kuppan M, Yamamoto D, Egawa G

105. Dynamic changes in gene-to-gene regulatory networks in response to SARS-CoV-2 infection.

Sci Rep

2021 May 27

Tanaka Y, Higashihara K, Nakazawa MA

106. Real-time, automatic, open-source sleep stage classification system using single EEG for mice.

Sci Rep

2021 May 27

Tezuka T, Kumar D, Singh S

107. Glycoproteomic analysis of the changes in protein N-glycosylation during neuronal differentiation in human-induced pluripotent stem cells and derived neuronal cells.

Sci Rep

2021 May 27

Kimura K, Koizumi T, Urasawa T

108. Effect of TNFα stimulation on expression of kidney risk inflammatory proteins in human umbilical vein endothelial cells cultured in hyperglycemia.

Sci Rep

2021 May 27

Md Dom ZI, Pipino C, Krolewski B

109. Complex network model indicates a positive effect of inspiratory muscles pre-activation on performance parameters in a judo match.

Sci Rep

2021 May 27

Cirino C, Gobatto CA, Pinto AS

110. The impact of hypothetical interventions on adiposity in adolescence.

Sci Rep

2021 May 27

Gebremariam MK, Nianogo RA, Lien N

111. Growth performance of five different strains of Nile tilapia (Oreochromis niloticus) introduced to Tanzania reared in fresh and brackish waters.

Sci Rep

2021 May 27

Moses M, Chauka LJ, de Koning DJ

112. A whole lung in silico model to estimate age dependent particle dosimetry.

Sci Rep

2021 May 27

Poorbahrami K, Vignon-Clementel IE, Shadden SC

113. Skyrmion crystals in centrosymmetric itinerant magnets without horizontal mirror plane.

Sci Rep

2021 May 27

Yambe R, Hayami S.

114. Comparison of minimal residual disease detection in multiple myeloma between the DuraClone and EuroFlow methods.

Sci Rep

2021 May 27

Yoroidaka T(#), Narita K(#), Takamatsu H

115. A high mutation load of m.14597A>G in MT-ND6 causes Leigh syndrome.

Sci Rep

2021 May 27

Kishita Y, Ishikawa K, Nakada K

116. 3-D thermal regime and dehydration processes around the regions of slow earthquakes along the Ryukyu Trench.

Sci Rep

2021 May 27

Suenaga N, Yoshioka S, Ji Y.

Several interplate seismic events, such as short-term slow slip events (S-SSEs) and low-frequency earthquakes (LFEs), have been identified in the Ryukyu Trench, southwestern Japan. As one of the specific characteristics of this seismicity, the depths at which S-SSEs occur at the plate interface beneath Okinawa Island are approximately 5-10 km shallower than those beneath the Yaeyama Islands. To elucidate the cause of this difference in depth, we constructed a three-dimensional, Cartesian thermomechanical subduction model and applied the subduction history of the Philippine Sea (PHS) plate in the model region. As a result, the interplate temperatures at which S-SSEs take place were estimated to range from 350 to 450 °C beneath Okinawa Island and from 500 to 600 °C beneath the Yaeyama Islands. The former temperature range is consistent with previous thermal modelling studies for the occurrence of slow earthquakes, but the latter temperature range is by approximately 150 °C higher than the former. Therefore, explaining how the depth difference in S-SSEs could be caused from the aspect of only the thermal regime is difficult. Using phase diagrams for hydrous minerals in the oceanic crust and mantle wedge, we also estimated the water content distribution on and above the plate interface of the PHS plate. Near the S-SSE fault planes, almost the same amount of dehydration associated with phase transformations of hydrous minerals from blueschist to amphibolite and from amphibolite to amphibole eclogite within the oceanic crust were inferred along Okinawa Island and the Yaeyama Islands, respectively. On the other hand, the phase transformations within the mantle wedge were inferred only beneath the Yaeyama Islands, whereas no specific phase transformation was inferred beneath Okinawa Island around the S-SSE occurrence region. Therefore, we conclude that dehydrated fluid derived from the oceanic crust at the plate interface would play a key role in the occurrence of S-SSEs.

117. Metabolomics study of fibroblasts damaged by UVB and BaP.

Sci Rep

2021 May 27

Yang X, Wang J, Wang H

118. Minor allele of rs55763075 located in MTHFR is associated with the risk of cognitive impairment after anesthesia via modulating miR-34b.

Sci Rep

2021 May 27

Li SY(#), Lei HS(#), Wu XY

119. Favourably regulating two-phase flow regime of flow boiling HFE-7100 in microchannels using silicon nanowires.

Sci Rep

2021 May 27

Alam T, Li W, Chang W

120. The association between fluoroquinolones and aortic dissection and aortic aneurysms: a systematic review and meta-analysis.

Sci Rep

2021 May 26

Wee I, Chin B, Syn N

121. Functional characterization of a loss-of-function mutant I324M of arginine vasopressin receptor 2 in X-linked nephrogenic diabetes insipidus.

Sci Rep

2021 May 26

Wang L(#), Guo W(#), Fang C(#)

122. Secular trends in health-related physical fitness among 11-14-year-old Croatian children and adolescents from 1999 to 2014.

Sci Rep

2021 May 26

Kasović M, Štefan L, Petrić V.

123. Transcranial direct current stimulation (tDCS) has beneficial effects on liver lipid accumulation and hepatic inflammatory parameters in obese rats.

Sci Rep

2021 May 26

Longo L, de Souza VEG, Stein DJ

124. Prediction of precise subsoiling based on analytical method, discrete element simulation and experimental data from soil bin.

Sci Rep

2021 May 26

Makange NR, Ji C, Nyalala I

125. Development of a yeast cell surface display method using the SpyTag/SpyCatcher system.

Sci Rep

2021 May 26

Kajiwara K, Aoki W, Koike N

126. Boron from net charge acceptor to donor and its effect on hydrogen uptake by novel Mg-B-electrochemically synthesized reduced graphene oxide.

Sci Rep

2021 May 26

Aditya MVVS, Panda S, Tatiparti SSV.

127. Seagrass blue carbon stocks and sequestration rates in the Colombian Caribbean.

Sci Rep

2021 May 26

Serrano O, Gómez-López DI, Sánchez-Valencia L

Seagrass ecosystems rank amongst the most efficient natural carbon sinks on earth, sequestering CO2 through photosynthesis and storing organic carbon (Corg) underneath their soils for millennia and thereby, mitigating climate change. However, estimates of Corg stocks and accumulation rates in seagrass meadows (blue carbon) are restricted to few regions, and further information on spatial variability is required to derive robust global estimates. Here we studied soil Corg stocks and accumulation rates in seagrass meadows across the Colombian Caribbean. We estimated that Thalassia testudinum meadows store 241 ± 118 Mg Corg ha-1 (mean ± SD) in the top 1 m-thick soils, accumulated at rates of 122 ± 62 and 15 ± 7 g Corg m-2 year-1 over the last ~ 70 years and up to 2000 years, respectively. The tropical climate of the Caribbean Sea and associated sediment run-off, together with the relatively high primary production of T. testudinum, influencing biotic and abiotic drivers of Corg storage linked to seagrass and soil respiration rates, explains their relatively high Corg stocks and accumulation rates when compared to other meadows globally. Differences in soil Corg storage among Colombian Caribbean regions are largely linked to differences in the relative contribution of Corg sources to the soil Corg pool (seagrass, algae Halimeda tuna, mangrove and seston) and the content of soil particles < 0.016 mm binding Corg and enhancing its preservation. Despite the moderate areal extent of T. testudinum in the Colombian Caribbean (661 km2), it sequesters around 0.3 Tg CO2 year-1, which is equivalent to ~ 0.4% of CO2 emissions from fossil fuels in Colombia. This study adds data from a new region to a growing dataset on seagrass blue carbon and further explores differences in meadow Corg storage based on biotic and abiotic environmental factors, while providing the basis for the implementation of seagrass blue carbon strategies in Colombia.

128. People serve themselves larger portions before a social meal.

Sci Rep

2021 May 26

Ruddock HK, Long EV, Brunstrom JM

129. Cooperative inhibition of SNARE-mediated vesicle fusion by α-synuclein monomers and oligomers.

Sci Rep

2021 May 26

Yoo G, Yeou S, Son JB

130. Ocular findings among patients surviving COVID-19.

Sci Rep

2021 May 26

Costa ÍF, Bonifácio LP, Bellissimo-Rodrigues F(#)

131. HDAC6 inhibitors sensitize non-mesenchymal triple-negative breast cancer cells to cysteine deprivation.

Sci Rep

2021 May 26

Alothaim T, Charbonneau M, Tang X.

132. Frequency domain measurements of melt pool recoil force using modal analysis.

Sci Rep

2021 May 26

Cullom T, Lough C, Altese N

133. Microbiota dysbiosis and functional outcome in acute ischemic stroke patients.

Sci Rep

2021 May 26

Chang Y, Woo HG, Jeong JH

Currently, few studies are reported on the composition of microbiota in stroke patients and the association with stroke prognosis. This study investigated the differing microbiota composition in stroke patients and confirmed the association of microbiota composition with poor functional outcome. Between January of 2018 and December of 2019, 198 patients with acute cerebral infarction were included in this study. For the case-control study, age and sex-matched normal healthy subjects (n = 200) were included when receiving their health screening examinations. We isolated bacterial extracellular membrane vesicles and extracted DNA from blood samples. Taxonomic assignments were performed by using the sequence reads of 16S rRNA genes following blood microbiota analysis. Statistical analysis was conducted appropriately by using Statistical Analysis System software. The mean age of the stroke patients were 63.7 ± 12.5 years, and the male sex was 58.5%. Of the total enrolled patients, poor functional outcome (modified Rankin Score ≥ 3) was noted in 19.7%. The principal component analysis of microbiota composition revealed significant differences between healthy control subjects and stroke patients. At the genus level, Aerococcaceae(f), ZB2(c), TM7-1(c), and Flavobacterium were significantly increased in stroke patients compared to the healthy controls, whereas Mucispirillum, rc4-4, Akkermansia, Clostridiales(o), Lactobacillus, and Stenotrophomonas were decreased considerably. For the functional outcome after ischemic stroke, Anaerococcus, Blautia, Dialister, Aerococcaceae(f), Propionibacterium, Microbacteriaceae(f), and Rothia were enriched in the group with good outcomes, whereas Ruminococcaceae(f) and Prevotella were enriched in the group with poor outcome. There was apparent dysbiosis of blood microbiota in patients with acute ischemic stroke compared to healthy people. Ruminococcaceae(f) and Prevotella were elevated in stroke patients with poor functional outcome.

134. Transcriptional analysis of the response of C. elegans to ethanol exposure.

Sci Rep

2021 May 26

Sterken MG(#), van Wijk MH(#), Quamme EC

135. ADAMTS12 acts as a tumor microenvironment related cancer promoter in gastric cancer.

Sci Rep

2021 May 26

Hou Y, Xu Y, Wu D.

136. Proteomic analysis-based discovery of a novel biomarker that differentiates intestinal Behçet's disease from Crohn's disease.

Sci Rep

2021 May 26

Park J(#), Jeong D(#), Chung YW(#)

137. Novel human neutralizing mAbs specific for Spike-RBD of SARS-CoV-2.

Sci Rep

2021 May 26

Passariello M(#), Gentile C(#), Ferrucci V

138. Flow of long chain hydrocarbons through carbon nanotubes (CNTs).

Sci Rep

2021 May 26

Asai P, Panja P, Velasco R

139. Extracellular DNA of slow growers of mycobacteria and its contribution to biofilm formation and drug tolerance.

Sci Rep

2021 May 26

Ilinov A, Nishiyama A, Namba H

140. Fast genetic mapping using insertion-deletion polymorphisms in Caenorhabditis elegans.

Sci Rep

2021 May 26

Hwang HY, Wang J.

141. A merged molecular representation learning for molecular properties prediction with a web-based service.

Sci Rep

2021 May 26

Kim H, Lee J, Ahn S

142. Temperature effect in physicochemical and bioactive behavior of biogenic hydroxyapatite obtained from porcine bones.

Sci Rep

2021 May 26

Forero-Sossa PA, Salazar-Martínez JD, Giraldo-Betancur AL

143. Origami-inspired thin-film shape memory alloy devices.

Sci Rep

2021 May 26

Velvaluri P, Soor A, Plucinsky P

144. Genetic variant of TTLL11 gene and subsequent ciliary defects are associated with idiopathic scoliosis in a 5-generation UK family.

Sci Rep

2021 May 26

Mathieu H, Patten SA, Aragon-Martin JA

145. First record of a new microsporidium pathogenic to Gonipterus platensis in Brazil.

Sci Rep

2021 May 26

Jordan C, de Carvalho VR, Mascarin GM

Microsporidia are naturally occurring fungal-related parasites that can infect nearly all animal hosts, but their biocontrol potential of insect pests is routinely overlooked in agriculture and forestry. This research brings the first report describing the natural occurrence of a microsporidium causing disease in field-collected populations of the invasive eucalyptus snout beetle, Gonipterus platensis (Coleoptera: Curculionidae), a major destructive pest of eucalyptus plantations in Brazil. Adult beetles were collected during field surveys in commercial eucalyptus plantations in southern Brazil to be examined and dissected with typical symptoms to verify presence of microsporidian spores in haemolymph. From 14 plantations in different sites, the natural infection occurrence in these populations ranged from 0 to 65%, while a lab colony exhibited an infection incidence of 70%. Spore density in haemolymph of symptomatic insects averaged 2.1 (± 0.4) × 107 spores/beetle. Symptoms in infected adults were identified by an abnormal abdomen with malformation of the second pair of wings, impairing their flight activity. Electron transmission microscopy of the pathogen showed morphological features similar to species belonging to the genus Nosema or Vairimorpha. Phylogenetic analysis of the full-length small subunit ribosomal RNA gene suggests this pathogen's placement in the genus Vairimorpha, but with a sequence identity of ~ 94% with the nearest neighbours. The low level of sequence identity suggests this pathogen may represent a novel taxon in the genus and further requires whole genome sequencing for definitive taxonomic resolution. These findings provide insights on the natural occurrence of this novel pathogen of this invasive pest in Eucalyptus plantations in Brazil. Further studies are needed to determine potential of this microsporidium in the design of conservative or augmentative biological control programs for this invasive pest.

146. Environmental DNA detection of an invasive ant species (Linepithema humile) from soil samples.

Sci Rep

2021 May 26

Yasashimoto T, Sakata MK, Sakita T

147. Subclinical hypothyroidism or isolated high TSH in hospitalized patients with chronic heart-failure and chronic renal-failure.

Sci Rep

2021 May 26

Bashkin A, Abu Saleh W, Shehadeh M

148. Leaky and waveguide modes in biperiodic holograms.

Sci Rep

2021 May 26

Keshmiri H(#), Armin F(#), Elsayad K

149. Heatline visualization of MHD natural convection heat transfer of nanofluid in a prismatic enclosure.

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2021 May 26

Islam T, Alam MN, Asjad MI

150. The climatic and genetic heritage of Italian goat breeds with genomic SNP data.

Sci Rep

2021 May 26

Cortellari M(#), Barbato M(#), Talenti A

151. Benchmark solution for the stability of plane Couette flow with net throughflow.

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2021 May 25

Shankar BM, Shivakumara IS.

152. The dynamics of evolutionary rescue from a novel pathogen threat in a host metapopulation.

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2021 May 25

Jiao J, Fefferman N.

153. Single channel properties of mitochondrial large conductance potassium channel formed by BK-VEDEC splice variant.

Sci Rep

2021 May 25

Gałecka S(#), Kulawiak B(#), Bednarczyk P

154. Behavioral variation according to feeding organ diversification in glossiphoniid leeches (Phylum: Annelida).

Sci Rep

2021 May 25

Kwak HJ(#), Kim JH(#), Kim JY

155. [18F]FDG-labelled stem cell PET imaging in different route of administrations and multiple animal species.

Sci Rep

2021 May 25

Nose N, Nogami S, Koshino K

Stem cell therapy holds great promise for tissue regeneration and cancer treatment, although its efficacy is still inconclusive and requires further understanding and optimization of the procedures. Non-invasive cell tracking can provide an important opportunity to monitor in vivo cell distribution in living subjects. Here, using a combination of positron emission tomography (PET) and in vitro 2-deoxy-2-[18F]fluoro-D-glucose ([18F]FDG) direct cell labelling, the feasibility of engrafted stem cell monitoring was tested in multiple animal species. Human mesenchymal stem cells (MSCs) were incubated with phosphate-buffered saline containing [18F]FDG for in vitro cell radiolabelling. The pre-labelled MSCs were administrated via peripheral vein in a mouse (n = 1), rats (n = 4), rabbits (n = 4) and non-human primates (n = 3), via carotid artery in rats (n = 4) and non-human primates (n = 3), and via intra-myocardial injection in rats (n = 5). PET imaging was started 10 min after cell administration using a dedicated small animal PET system for a mouse and rats. A clinical PET system was used for the imaging of rabbits and non-human primates. After MSC administration via peripheral vein, PET imaging revealed intense radiotracer signal from the lung in all tested animal species including mouse, rat, rabbit, and non-human primate, suggesting administrated MSCs were trapped in the lung tissue. Furthermore, the distribution of the PET signal significantly differed based on the route of cell administration. Administration via carotid artery showed the highest activity in the head, and intra-myocardial injection increased signal from the heart. In vitro [18F]FDG MSC pre-labelling for PET imaging is feasible and allows non-invasive visualization of initial cell distribution after different routes of cell administration in multiple animal models. Those results highlight the potential use of that imaging approach for the understanding and optimization of stem cell therapy in translational research.

156. Efficacy of continuous apical negative ultrasonic irrigation (CANUI) in penetration of simulated lateral canals in extracted teeth.

Sci Rep

2021 May 25

Castelo-Baz P, Lozano FJR, Ginzo-Villamayor MJ

157. Brainwide functional networks associated with anatomically- and functionally-defined hippocampal subfields using ultrahigh-resolution fMRI.

Sci Rep

2021 May 25

Chang WT, Langella SK, Tang Y

158. Tolerance and decolorization potential of duckweed (Lemna gibba) to C.I. Basic Green 4.

Sci Rep

2021 May 25

Singh H, Raj S, Kumar D

159. Genetics of symptom remission in outpatients with COVID-19.

Sci Rep

2021 May 25

Dubé MP, Lemaçon A, Barhdadi A

160. Deceleration capacity of heart rate variability as a predictor of sedation related hypotension.

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2021 May 25

Tsai FF, Liu CM, Wang HP

161. The association between hepatitis C virus infection and renal cell cancer, prostate cancer, and bladder cancer: a systematic review and meta-analysis.

Sci Rep

2021 May 25

Ma Y(#), Huang Z(#), Jian Z(#)

162. Soil organic carbon cycling in response to simulated soil moisture variation under field conditions.

Sci Rep

2021 May 25

Singh S, Mayes MA, Shekoofa A

163. Influence of the 5'-terminal sequences on the 5'-UTR structure of HIV-1 genomic RNA.

Sci Rep

2021 May 25

Obayashi CM, Shinohara Y, Masuda T

164. Splenic uptake on FDG PET/CT correlates with Kikuchi-Fujimoto disease severity.

Sci Rep

2021 May 25

Seong H(#), Jeong YH(#), Lee WJ

165. A reliable set of reference genes to normalize oxygen-dependent cytoglobin gene expression levels in melanoma.

Sci Rep

2021 May 25

De Backer J(#), Maric D(#), Bosman M

166. Integrated RNA and miRNA sequencing analysis reveals a complex regulatory network of Magnolia sieboldii seed germination.

Sci Rep

2021 May 25

Mei M, Wei J, Ai W

167. Identification of novel source of salt tolerance in local bread wheat germplasm using morpho-physiological and biochemical attributes.

Sci Rep

2021 May 25

Hussain N, Ghaffar A, Zafar ZU

168. Effects of elevated temperature on the corrosion resistance of silver-cobalt oxide-titanium dioxide (Ag/Co(3)O(4)/TiO(2)) nanocomposites coating on AISI 1020.

Sci Rep

2021 May 25

Ibrahim M, Agboola JB, Abdulkareem SA

169. Alginate hydrogel beads embedded with drug-bearing polycaprolactone microspheres for sustained release of paclobutrazol.

Sci Rep

2021 May 25

Mun A, Simaan Yameen H, Edelbaum G

170. Protein model accuracy estimation empowered by deep learning and inter-residue distance prediction in CASP14.

Sci Rep

2021 May 25

Chen X(#), Liu J(#), Guo Z(#)

171. White matter hyperintensity in different migraine subtypes.

Sci Rep

2021 May 25

Dobrynina LA, Suslina AD, Gubanova MV

172. Positive Epstein-Barr virus detection in coronavirus disease 2019 (COVID-19) patients.

Sci Rep

2021 May 25

Chen T(#), Song J(#), Liu H

173. Elastic transformation of histological slices allows precise co-registration with microCT data sets for a refined virtual histology approach.

Sci Rep

2021 May 25

Albers J, Svetlove A, Alves J

174. Beauvericin potentiates the activity of pesticides by neutralizing the ATP-binding cassette transporters in arthropods.

Sci Rep

2021 May 25

Al Khoury C, Nemer N, Nemer G.

Multi-drug resistance is posing major challenges in suppressing the population of pests. Many herbivores develop resistance, causing a prolonged survival after exposure to a previously effective pesticide. Consequently, resistant pests reduce the yield of agricultural production, causing significant economic losses and reducing food security. Therefore, overpowering resistance acquisition of crop pests is a must. The ATP binding cassette transporters (ABC transporters) are considered as the main participants to the pesticide efflux and their neutralization will greatly contribute to potentiate failed treatments. Real-Time PCR analysis of 19 ABC transporter genes belonging to the ABCB, ABCC, ABCG, and ABCH revealed that a broad range of efflux pumps is activated in response to the exposure to pesticides. In this study, we used beauvericin (BEA), a known ABC transporters modulator, to resensitize different strains of Tetranychus urticae after artificial selection for resistance to cyflumetofen, bifenazate, and abamectin. Our results showed that the combinatorial treatment of pesticide (manufacturer's recommended doses) + BEA (sublethal doses: 0.15 mg/L) significantly suppressed the resistant populations of T. urticae when compared to single-drug treatments. Moreover, after selective pressure for 40 generations, the LC50 values were significantly reduced from 36.5, 44.7, and 94.5 (pesticide) to 8.3, 12.5, and 23.4 (pesticide + BEA) for cyflumetofen, bifenazate, and abamectin, respectively. While the downstream targets for BEA are still elusive, we demonstrated hereby that it synergizes with sub-lethal doses of different pesticides and increases their effect by inhibiting ABC transporters. This is the first report to document such combinatorial activity of BEA against higher invertebrates paving the way for its usage in treating refractory cases of resistance to pesticides. Moreover, we demonstrated, for the first time, using in silico techniques, the higher affinity of BEA to ABC transformers subfamilies when compared to xenobiotics; thus, elucidating the pathway of the mycotoxin.

175. Variable coastal hypoxia exposure and drivers across the southern California Current.

Sci Rep

2021 May 25

Low NHN, Micheli F, Aguilar JD

176. A novel synthetic microtubule inhibitor exerts antiproliferative effects in multidrug resistant cancer cells and cancer stem cells.

Sci Rep

2021 May 24

Park M(#), Hwang JW(#), Cho Y

177. Remote ischemic preconditioning improves tissue oxygenation in a porcine model of controlled hemorrhage without fluid resuscitation.

Sci Rep

2021 May 24

Yaniv G(#), Eisenkraft A(#), Gavish L

178. Decline in influenza cases in Mexico after the implementation of public health measures for COVID-19.

Sci Rep

2021 May 24

Arellanos-Soto D, Padilla-Rivas G, Ramos-Jimenez J

179. The roles and prognostic significance of ABI1-TSV-11 expression in patients with left-sided colorectal cancer.

Sci Rep

2021 May 24

Zhang Y(#), Zhong Z(#), Li M

180. Abiraterone induces SLCO1B3 expression in prostate cancer via microRNA-579-3p.

Sci Rep

2021 May 24

Barbier RH, McCrea EM, Lee KY

181. Laparoscopic approach to refractory extraspinal sciatica and pudendal pain caused by intrapelvic nerve entrapment.

Sci Rep

2021 May 24

Lemos N, Sermer C, Fernandes G

182. Air-ozonolysis activation of polyolefins versus use of laden finishing to form contact-active nonwoven materials.

Sci Rep

2021 May 24

Kiel S(#), Klein M(#), Kroupitski Y

183. Maternal mental health and gestational weight gain in a Brazilian Cohort.

Sci Rep

2021 May 24

Farias DR, Carrilho TRB, Freitas-Costa NC

184. The limit of tolerable micromotion for implant osseointegration: a systematic review.

Sci Rep

2021 May 24

Kohli N, Stoddart JC, van Arkel RJ.

185. Green synthesis of multifunctional carbon coated copper oxide nanosheets and their photocatalytic and antibacterial activities.

Sci Rep

2021 May 24

Bibi H, Iqbal M, Wahab H

186. COVID-19 awareness, knowledge and perception towards digital health in an urban multi-ethnic Asian population.

Sci Rep

2021 May 24

Teo CL(#), Chee ML(#), Koh KH

187. A two-hybrid system reveals previously uncharacterized protein-protein interactions within the Helicobacter pylori NIF iron-sulfur maturation system.

Sci Rep

2021 May 24

Benoit SL, Agudelo S, Maier RJ.

188. Power determination in vitamin D randomised control trials and characterising factors affecting it through a novel simulation-based tool.

Sci Rep

2021 May 24

Wyse J(#), Mangan R(#), Zgaga L(#).

189. Predicting MHC I restricted T cell epitopes in mice with NAP-CNB, a novel online tool.

Sci Rep

2021 May 24

Wert-Carvajal C(#), Sánchez-García R(#), Macías JR

190. A single neuron subset governs a single coactive neuron circuit in Hydra vulgaris, representing a possible ancestral feature of neural evolution.

Sci Rep

2021 May 24

Noro Y, Shimizu H, Mineta K

191. Molecular model of a sensor of two-component signaling system.

Sci Rep

2021 May 24

Ryzhykau YL(#), Orekhov PS(#), Rulev MI(#)

192. A novel application of bubble-eye strain of Carassius auratus for ex vivo fish immunological studies.

Sci Rep

2021 May 24

Nakajima H, Miyashita A, Hamamoto H

193. SARS-CoV-2 and other human coronavirus show genome patterns previously associated to reduced viral recognition and altered immune response.

Sci Rep

2021 May 21

Franzo G.

A new pandemic caused by the betacoronavirus SARS-CoV-2 originated in China in late 2019. Although often asymptomatic, a relevant percentage of affected people can develop severe pneumonia. Initial evidence suggests that dysregulation of the immune response could contribute to the pathogenesis, as previously demonstrated for SARS-CoV. The presence of genome composition features involved in delaying viral recognition is herein investigated for human coronaviruses (HCoVs), with a special emphasis on SARS-CoV-2. A broad collection of HCoVs polyprotein, envelope, matrix, nucleocapsid and spike coding sequences was downloaded and several statistics representative of genome composition and codon bias were investigated. A model able to evaluate and test the presence of a significant under- or over-representation of dinucleotide pairs while accounting for the underlying codon bias and protein sequence was also implemented. The study revealed the significant under-representation of CpG dinucleotide pair in all HcoV, but especially in SARS-CoV and even more in SARS-CoV-2. The presence of forces acting to minimize CpG content was confirmed by relative synonymous codon usage pattern. Codons containing the CpG pair were severely under-represented, primarily in the polyprotein and spike coding sequences of SARS-CoV-2. Additionally, a significant under-representation of the TpA pair was observed in the N and S region of SARS-CoV and SARS-CoV-2. Increasing experimental evidence has proven that CpG and TpA are targeted by innate antiviral host defences, contributing both to RNA degradation and RIG-1 mediated interferon production. The low content of these dinucleotides could contribute to a delayed interferon production, dysregulated immune response, higher viral replication and poor outcome. Significantly, the RIG-1 signalling pathway was proven to be defective in elderlies, suggesting a likely interaction between limited viral recognition and lower responsiveness in interferon production that could justify the higher disease severity and mortality in older patients.

194. Mesenchymal stromal cell mitochondrial transfer to human induced T-regulatory cells mediates FOXP3 stability.

Sci Rep

2021 May 21

Do JS, Zwick D, Kenyon JD

195. Antimicrobial responses of peripheral and central nervous system glia against Staphylococcus aureus.

Sci Rep

2021 May 21

Choudhury IN(#), Chacko A(#), Delbaz A

196. Antimony induced structural and ultrastructural changes in Trapa natans.

Sci Rep

2021 May 21

Baruah S(#), Bora MS(#), Dutta S

197. Enhanced condensation heat transfer using porous silica inverse opal coatings on copper tubes.

Sci Rep

2021 May 21

Adera S, Naworski L, Davitt A

198. Transcriptomic and metabolomic joint analysis reveals distinct flavonoid biosynthesis regulation for variegated testa color development in peanut (Arachis hypogaea L.).

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2021 May 21

Hu M, Li J, Hou M

199. Complete mitochondrial genomes and phylogenetic relationships of the genera Nephila and Trichonephila (Araneae, Araneoidea).

Sci Rep

2021 May 21

Yong HS, Song SL, Chua KO

200. Novel late-stage radiosynthesis of 5-[18F]-trifluoromethyl-1,2,4-oxadiazole (TFMO) containing molecules for PET imaging.

Sci Rep

2021 May 21

Turkman N, Liu D, Pirola I.

201. Flow cytometry detection of sustained humoral immune response (IgG + IgA) against native spike glycoprotein in asymptomatic/mild SARS-CoV-2 infection.

Sci Rep

2021 May 21

Piñero P, Marco De La Calle FM, Horndler L

202. The nature of Pu-bearing particles from the Maralinga nuclear testing site, Australia.

Sci Rep

2021 May 21

Cook M, Etschmann B, Ram R

203. Gate-tuned anomalous Hall effect driven by Rashba splitting in intermixed LaAlO(3)/GdTiO(3)/SrTiO(3).

Sci Rep

2021 May 21

Lebedev N(#), Stehno M(#), Rana A

204. Glucose and NAADP trigger elementary intracellular β-cell Ca(2+) signals.

Sci Rep

2021 May 21

Heister PM, Powell T, Galione A.

Pancreatic β-cells release insulin upon a rise in blood glucose. The precise mechanisms of stimulus-secretion coupling, and its failure in Diabetes Mellitus Type 2, remain to be elucidated. The consensus model, as well as a class of currently prescribed anti-diabetic drugs, are based around the observation that glucose-evoked ATP production in β-cells leads to closure of cell membrane ATP-gated potassium (KATP) channels, plasma membrane depolarisation, Ca2+ influx, and finally the exocytosis of insulin granules. However, it has been demonstrated by the inactivation of this pathway using genetic and pharmacological means that closure of the KATP channel alone may not be sufficient to explain all β-cell responses to glucose elevation. We have previously proposed that NAADP-evoked Ca2+ release is an important step in stimulus-secretion coupling in pancreatic β-cells. Here we show using total internal reflection fluorescence (TIRF) microscopy that glucose as well as the Ca2+ mobilising messenger nicotinic acid adenine dinucleotide phosphate (NAADP), known to operate in β-cells, lead to highly localised elementary intracellular Ca2+ signals. These were found to be obscured by measurements of global Ca2+ signals and the action of powerful SERCA-based sequestration mechanisms at the endoplasmic reticulum (ER). Building on our previous work demonstrating that NAADP-evoked Ca2+ release is an important step in stimulus-secretion coupling in pancreatic β-cells, we provide here the first demonstration of elementary Ca2+ signals in response to NAADP, whose occurrence was previously suspected. Optical quantal analysis of these events reveals a unitary event amplitude equivalent to that of known elementary Ca2+ signalling events, inositol trisphosphate (IP3) receptor mediated blips, and ryanodine receptor mediated quarks. We propose that a mechanism based on these highly localised intracellular Ca2+ signalling events mediated by NAADP may initially operate in β-cells when they respond to elevations in blood glucose.

205. A novel method for in situ TEM measurements of adhesion at the diamond-metal interface.

Sci Rep

2021 May 21

Loginov PA, Sidorenko DA, Orekhov AS

206. Fully integrated ultra-sensitive electronic nose based on organic field-effect transistors.

Sci Rep

2021 May 21

Anisimov DS, Chekusova VP, Trul AA

207. The impact of improved data quality on the prevalence estimates of anthropometric measures using DHS datasets in India.

Sci Rep

2021 May 21

Harkare HV, Corsi DJ, Kim R

208. β-Galactosidase is a target enzyme for detecting peritoneal metastasis of gastric cancer.

Sci Rep

2021 May 21

Kubo H, Murayama Y, Ogawa S

209. A functional requirement for sex-determination M/m locus region lncRNA genes in Aedes aegypti female larvae.

Sci Rep

2021 May 20

Mysore K, Hapairai LK, Li P

210. Study on the adsorption properties of methyl orange by natural one-dimensional nano-mineral materials with different structures.

Sci Rep

2021 May 20

Wu L, Liu X, Lv G

211. Prognostic value of low skeletal muscle mass in patient treated by exclusive curative radiochemotherapy for a NSCLC.

Sci Rep

2021 May 20

Mallet R, Decazes P, Modzelewski R

Low skeletal muscle mass is a well-known prognostic factor for patients treated for a non-small-cell lung cancer by surgery or chemotherapy. However, its impact in patients treated by exclusive radiochemotherapy has never been explored. Our study tries to evaluate the prognostic value of low skeletal muscle mass and other antropometric parameters on this population. Clinical, nutritional and anthropometric date were collected for 93 patients treated by radiochemotherapy for a NSCLC. Anthropometric parameters were measured on the PET/CT by two methods. The first method was a manual segmentation at level L3, used to define Muscle Body Area (MBAL3), Visceral Fat Area (VFAL3) and Subcutaneous Fat Area (SCFAL3). The second method was an software (Anthropometer3D), allowing an automatic multislice measurement of Lean Body Mass (LBMAnthro3D), Fat Body Mass (FBMAnthro3D), Muscle Body Mass (MBMAnthro3D), Visceral Fat Mass (VFMAnthro3D), and Sub-Cutaneous Fat Mass (SCFMAnthro3D) on the PET/CT. All anthropometrics parameters were normalised by the patient's height. The primary end point was overall survival time. Univariate and then stepwise multivariate cox analysis were performed for significant parameters. Finally, Spearman's correlation between MBAL3 and MBMAnthro3D was assessed. Forty-one (44%) patients had low skeletal muscle mass. The median overall survival was 18 months for low skeletal muscle mass patients versus 36 months for non-low skeletal muscle mass patients (p = 0.019). Low skeletal muscle mass (HR = 1.806, IC95% [1.09-2.98]), serums albumin level < 35 g/l (HR = 2.203 [1.19-4.09]), Buzby Index < 97.5 (HR = 2.31 [1.23-4.33]), WHO score = 0 (HR = 0.59 [0.31-0.86] and MBMAnthro3D < 8.56 kg/m2 (HR = 2.36 [1.41-3.90]) were the only significant features in univariates analysis. In the stepwise multivariate Cox analysis, only MBMAnthro3D < 8.56 kg/m2 (HR = 2.16, p = 0.003) and WHO score = 0 (HR = 0.59, p = 0.04) were significant. Finally, muscle quantified by MBAL3 and MBMAnthro3D were found to be highly correlated (Spearman = 0.9). Low skeletal muscle mass, assessed on the pre-treatment PET/CT is a powerful prognostic factor in patient treated by radiochemotherapy for a NSCLC. The automatic software Anthropometer3D can easily identify patients a risk that could benefit an adapted therapy.

212. Clinical characterization of respiratory large droplet production during common airway procedures using high-speed imaging.

Sci Rep

2021 May 20

Mueller SK, Veltrup R, Jakubaß B

213. 3D free-hand ultrasound to register anatomical landmarks at the pelvis and localize the hip joint center in lean and obese individuals.

Sci Rep

2021 May 20

Horsak B, Schwab C, Durstberger S

3D free-hand ultrasound (3DFUS) is becoming increasingly popular to assist clinical gait analysis because it is cost- and time-efficient and does not expose participants to radiation. The aim of this study was to evaluate its reliability in localizing the anterior superior iliac spine (ASIS) at the pelvis and the hip joint centers (HJC). Additionally, we evaluated its accuracy to get a rough estimation of the potential to use of 3DFUS to segment bony surface. This could offer potential to register medical images to motion capture data in future. To evaluate reliability, a test-retest study was conducted in 16 lean and 19 obese individuals. The locations of the ASIS were determined by manual marker placement (MMP), an instrumented pointer technique (IPT), and with 3DFUS. The HJC location was also determined with 3DFUS. To quantify reliability, intraclass correlation coefficients (ICCs), the standard error of measurement (SEm), among other statistical parameters, were calculated for the identified locations between the test and retest. To assess accuracy, the surface of a human plastic pelvic phantom was segmented with 3DFUS in a distilled water bath in 27 trials and compared to a 3D laser scan of the pelvis. Regarding reliability, the MMP, but especially the IPT showed high reliability in lean (SEm: 2-3 mm) and reduced reliability in obese individuals (SEm: 6-15 mm). Compared to MMP and IPT, 3DFUS presented lower reliability in the lean group (SEm: 2-4 mm vs. 2-8 mm, respectively) but slightly better values in the obese group (SEm: 7-11 mm vs. 6-16 mm, respectively). Correlations between test-retest reliability and torso body fat mass (% of body mass) indicated a moderate to strong relationship for MMP and IPT but only a weak correlation for the 3DFUS approach. The water-bath experiments indicated an acceptable level of 3.5 (1.7) mm of accuracy for 3DFUS in segmenting bone surface. Despite some difficulties with single trials, our data give further rise to the idea that 3DFUS could serve as a promising tool in future to inform marker placement and hip joint center location, especially in groups with higher amount of body fat.

214. Analysing wideband absorbance immittance in normal and ears with otitis media with effusion using machine learning.

Sci Rep

2021 May 20

Grais EM(#), Wang X(#), Wang J(#)

215. A super-potent tetramerized ACE2 protein displays enhanced neutralization of SARS-CoV-2 virus infection.

Sci Rep

2021 May 19

Miller A, Leach A, Thomas J

216. Behavior and properties of water in silicate melts under deep mantle conditions.

Sci Rep

2021 May 19

Karki BB, Ghosh DB, Karato SI.

Water (H2O) as one of the most abundant fluids present in Earth plays crucial role in the generation and transport of magmas in the interior. Though hydrous silicate melts have been studied extensively, the experimental data are confined to relatively low pressures and the computational results are still rare. Moreover, these studies imply large differences in the way water influences the physical properties of silicate magmas, such as density and electrical conductivity. Here, we investigate the equation of state, speciation, and transport properties of water dissolved in Mg1-xFexSiO3 and Mg2(1-x)Fe2xSiO4 melts (for x = 0 and 0.25) as well as in its bulk (pure) fluid state over the entire mantle pressure regime at 2000-4000 K using first-principles molecular dynamics. The simulation results allow us to constrain the partial molar volume of the water component in melts along with the molar volume of pure water. The predicted volume of silicate melt + water solution is negative at low pressures and becomes almost zero above 15 GPa. Consequently, the hydrous component tends to lower the melt density to similar extent over much of the mantle pressure regime irrespective of composition. Our results also show that hydrogen diffuses fast in silicate melts and enhances the melt electrical conductivity in a way that differs from electrical conduction in the bulk water. The speciation of the water component varies considerably from the bulk water structure as well. Water is dissolved in melts mostly as hydroxyls at low pressure and as -O-H-O-, -O-H-O-H- and other extended species with increasing pressure. On the other hand, the pure water behaves as a molecular fluid below 15 GPa, gradually becoming a dissociated fluid with further compression. On the basis of modeled density and conductivity results, we suggest that partial melts containing a few percent of water may be gravitationally trapped both above and below the upper mantle-transition region. Moreover, such hydrous melts can give rise to detectable electrical conductance by means of electromagnetic sounding observations.

217. Drop homotopic effects of masseter-muscle pain on somatosensory sensitivity in healthy participants.

Sci Rep

2021 May 19

Hayakawa H, Iida T, Honda-Sakaki M

218. Prediction of velocity profile of water based copper nanofluid in a heated porous tube using CFD and genetic algorithm.

Sci Rep

2021 May 19

Ciano T, Ferrara M, Babanezhad M

The heat transfer improvements by simultaneous usage of the nanofluids and metallic porous foams are still an attractive research area. The Computational fluid dynamics (CFD) methods are widely used for thermal and hydrodynamic investigations of the nanofluids flow inside the porous media. Almost all studies dedicated to the accurate prediction of the CFD approach. However, there are not sufficient investigations on the CFD approach optimization. The mesh increment in the CFD approach is one of the challenging concepts especially in turbulent flows and complex geometries. This study, for the first time, introduces a type of artificial intelligence algorithm (AIA) as a supplementary tool for helping the CFD. According to the idea of this study, the CFD simulation is done for a case with low mesh density. The artificial intelligence algorithm uses learns the CFD driven data. After the intelligence achievement, the AIA could predict the fluid parameters for the infinite number of nodes or dense mesh without any limitations. So, there is no need to solve the CFD models for further nodes. This study is specifically focused on the genetic algorithm-based fuzzy inference system (GAFIS) to predict the velocity profile of the water-based copper nanofluid turbulent flow in a porous tube. The most intelligent GAFIS could perform the most accurate prediction of the velocity. Hence, the intelligence of GAFIS is tested for different values of cluster influence range (CIR), squash factor(SF), accept ratio (AR) and reject ratio (RR), the population size (PS), and the percentage of crossover (PC). The maximum coefficient of determination (~ 0.97) was related to the PS of 30, the AR of 0.6, the PC of 0.4, CIR of 0.15, the SF 1.15, and the RR of 0.05. The GAFIS prediction of the fluid velocity was in great agreement with the CFD. In the most intelligent condition, the velocity profile predicted by GAFIS was similar to the CFD. The nodes increment from 537 to 7671 was made by the GAFIS. The new predictions of the GAFIS covered all CFD results.

219. X-ray fan beam coded aperture transmission and diffraction imaging for fast material analysis.

Sci Rep

2021 May 19

Stryker S, Greenberg JA, McCall SJ

220. Prediction of population behavior of Listeria monocytogenes in food using machine learning and a microbial growth and survival database.

Sci Rep

2021 May 19

Hiura S, Koseki S, Koyama K.

221. Compact solid-state optical phased array beam scanners based on polymeric photonic integrated circuits.

Sci Rep

2021 May 19

Kim SM, Lee ES, Chun KW

222. Experiential ownership and body ownership are different phenomena.

Sci Rep

2021 May 19

Liang C, Lin WH, Chang TY

223. Feasibility of predicting allele specific expression from DNA sequencing using machine learning.

Sci Rep

2021 May 19

Zhang Z, van Dijk F, de Klein N

224. Decreased renal function increases the nighttime urine volume rate by carryover of salt excretion to the nighttime.

Sci Rep

2021 May 19

Takezawa K, Kuribayashi S, Okada K

225. Monolingual and bilingual language networks in healthy subjects using functional MRI and graph theory.

Sci Rep

2021 May 19

Li Q(#), Pasquini L(#), Del Ferraro G

226. An inter-laboratory study to investigate the impact of the bioinformatics component on microbiome analysis using mock communities.

Sci Rep

2021 May 19

O'Sullivan DM, Doyle RM, Temisak S

Despite the advent of whole genome metagenomics, targeted approaches (such as 16S rRNA gene amplicon sequencing) continue to be valuable for determining the microbial composition of samples. Amplicon microbiome sequencing can be performed on clinical samples from a normally sterile site to determine the aetiology of an infection (usually single pathogen identification) or samples from more complex niches such as human mucosa or environmental samples where multiple microorganisms need to be identified. The methodologies are frequently applied to determine both presence of micro-organisms and their quantity or relative abundance. There are a number of technical steps required to perform microbial community profiling, many of which may have appreciable precision and bias that impacts final results. In order for these methods to be applied with the greatest accuracy, comparative studies across different laboratories are warranted. In this study we explored the impact of the bioinformatic approaches taken in different laboratories on microbiome assessment using 16S rRNA gene amplicon sequencing results. Data were generated from two mock microbial community samples which were amplified using primer sets spanning five different variable regions of 16S rRNA genes. The PCR-sequencing analysis included three technical repeats of the process to determine the repeatability of their methods. Thirteen laboratories participated in the study, and each analysed the same FASTQ files using their choice of pipeline. This study captured the methods used and the resulting sequence annotation and relative abundance output from bioinformatic analyses. Results were compared to digital PCR assessment of the absolute abundance of each target representing each organism in the mock microbial community samples and also to analyses of shotgun metagenome sequence data. This ring trial demonstrates that the choice of bioinformatic analysis pipeline alone can result in different estimations of the composition of the microbiome when using 16S rRNA gene amplicon sequencing data. The study observed differences in terms of both presence and abundance of organisms and provides a resource for ensuring reproducible pipeline development and application. The observed differences were especially prevalent when using custom databases and applying high stringency operational taxonomic unit (OTU) cut-off limits. In order to apply sequencing approaches with greater accuracy, the impact of different analytical steps needs to be clearly delineated and solutions devised to harmonise microbiome analysis results.

227. Unique evolutionary trajectories of breast cancers with distinct genomic and spatial heterogeneity.

Sci Rep

2021 May 19

Phung TN, Webster TH, Lenkiewicz E

228. Human delta like 1-expressing human mesenchymal stromal cells promote human T cell development and antigen-specific response in humanized NOD/SCID/IL-2R[Formula: see text](null) (NSG) mice.

Sci Rep

2021 May 19

Kwon DH, Park JB, Lee JS

229. Altered endothelial dysfunction-related miRs in plasma from ME/CFS patients.

Sci Rep

2021 May 19

Blauensteiner J, Bertinat R, León LE

230. Hidden order across online extremist movements can be disrupted by nudging collective chemistry.

Sci Rep

2021 May 19

Velásquez N, Manrique P, Sear R

231. A bispecific antibody agonist of the IL-2 heterodimeric receptor preferentially promotes in vivo expansion of CD8 and NK cells.

Sci Rep

2021 May 19

Harris KE(#), Lorentsen KJ(#), Malik-Chaudhry HK

232. Development of marker-free transgenic pigeon pea (Cajanus cajan) expressing a pod borer insecticidal protein.

Sci Rep

2021 May 18

Sarkar S, Roy S, Ghosh SK.

233. ITGA2, LAMB3, and LAMC2 may be the potential therapeutic targets in pancreatic ductal adenocarcinoma: an integrated bioinformatics analysis.

Sci Rep

2021 May 18

Islam S, Kitagawa T, Baron B

Pancreatic ductal adenocarcinoma (PDAC) is the most common form of pancreatic cancer with an abysmal prognosis rate over the last few decades. Early diagnosis and prevention could effectively combat this malignancy. Therefore, it is crucial to discover potential biomarkers to identify asymptomatic premalignant or early malignant tumors of PDAC. Gene expression analysis is a powerful technique to identify candidate biomarkers involved in disease progression. In the present study, five independent gene expression datasets, including 321 PDAC tissues and 208 adjacent non-cancerous tissue samples, were subjected to statistical and bioinformatics analysis. A total of 20 differentially expressed genes (DEGs) were identified in PDAC tissues compared to non-cancerous tissue samples. Gene ontology and pathway enrichment analysis showed that DEGs were mainly enriched in extracellular matrix (ECM), cell adhesion, ECM-receptor interaction, and focal adhesion signaling. The protein-protein interaction network was constructed, and the hub genes were evaluated. Collagen type XII alpha 1 chain (COL12A1), fibronectin 1 (FN1), integrin subunit alpha 2 (ITGA2), laminin subunit beta 3 (LAMB3), laminin subunit gamma 2 (LAMC2), thrombospondin 2 (THBS2), and versican (VCAN) were identified as hub genes. The correlation analysis revealed that identified hub genes were significantly interconnected. Wherein COL12A1, FN1, ITGA2, LAMB3, LAMC2, and THBS2 were significantly associated with PDAC pathological stages. The Kaplan-Meier survival plots revealed that ITGA2, LAMB3, and LAMC2 expression were inversely correlated with a prolonged patient survival period. Furthermore, the Human Protein Atlas database was used to validate the expression and cellular origins of hub genes encoded proteins. The protein expression of hub genes was higher in pancreatic cancer tissue than in normal pancreatic tissue samples, wherein ITGA2, LAMB3, and LAMC2 were exclusively expressed in pancreatic cancer cells. Pancreatic cancer cell-specific expression of these three proteins may play pleiotropic roles in cancer progression. Our results collectively suggest that ITGA2, LAMB3, and LAMC2 could provide deep insights into pancreatic carcinogenesis molecular mechanisms and provide attractive therapeutic targets.

234. Biosynthesis of silver nanoparticles for the fabrication of non cytotoxic and antibacterial metallic polymer based nanocomposite system.

Sci Rep

2021 May 18

Raza S, Ansari A, Siddiqui NN

Nanomaterials have significantly contributed in the field of nanomedicine as this subject matter has combined the usefulness of natural macromolecules with organic and inorganic nanomaterials. In this respect, various types of nanocomposites are increasingly being explored in order to discover an effective approach in controlling high morbidity and mortality rate that had triggered by the evolution and emergence of multidrug resistant microorganisms. Current research is focused towards the production of biogenic silver nanoparticles for the fabrication of antimicrobial metallic-polymer-based non-cytotoxic nanocomposite system. An ecofriendly approach was adapted for the production of silver nanoparticles using fungal biomass (Aspergillus fumigatus KIBGE-IB33). The biologically synthesized nanoparticles were further layered with a biodegradable macromolecule (chitosan) to improve and augment the properties of the developed nanocomposite system. Both nanostructures were characterized using different spectrographic analyses including UV-visible and scanning electron microscopy, energy dispersive X-ray analysis, dynamic light scattering, and Fourier transform infrared spectroscopic technique. The biologically mediated approach adapted in this study resulted in the formation of highly dispersed silver nanoparticles that exhibited an average nano size and zeta potential value of 05 nm (77.0%) and - 22.1 mV, respectively with a polydispersity index of 0.4. Correspondingly, fabricated silver-chitosan nanocomposites revealed a size of 941 nm with a zeta potential and polydispersity index of + 63.2 mV and 0.57, respectively. The successful capping of chitosan on silver nanoparticles prevented the agglomeration of nanomaterial and also facilitated the stabilization of the nano system. Both nanoscopic entities exhibited antimicrobial potential against some pathogenic bacterial species but did not displayed any antifungal activity. The lowest minimal inhibitory concentration of nanocomposite system (1.56 µg ml-1) was noticed against Enterococcus faecalis ATCC 29212. Fractional inhibitory concentration index of the developed nanocomposite system confirmed its improved synergistic behavior against various bacterial species with no cytotoxic effect on NIH/3T3 cell lines. Both nanostructures, developed in the present study, could be utilized in the form of nanomedicines or nanocarrier system after some quantifiable trials as both of them are nonhazardous and have substantial antibacterial properties.

235. A python code for automatic construction of Fischer plots using proxy data.

Sci Rep

2021 May 18

Yang D, Huang Y, Chen Z

236. Diurnal evolution of urban tree temperature at a city scale.

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2021 May 18

Vo TT, Hu L.

237. Incremental value of QT interval for the prediction of obstructive coronary artery disease in patients with chest pain.

Sci Rep

2021 May 18

Cho DH, Choi J, Kim MN

238. X-chromosome variants are associated with aldosterone producing adenomas.

Sci Rep

2021 May 18

Dutta RK, Larsson M, Arnesen T

239. Metformin treatment response is dependent on glucose growth conditions and metabolic phenotype in colorectal cancer cells.

Sci Rep

2021 May 18

Alhourani AH(#), Tidwell TR(#), Bokil AA

240. Implementing a method for engineering multivalency to substantially enhance binding of clinical trial anti-SARS-CoV-2 antibodies to wildtype spike and variants of concern proteins.

Sci Rep

2021 May 18

Leach A(#), Miller A(#), Bentley E

241. Serological surveys to inform SARS-CoV-2 epidemic curve: a cross-sectional study from Odisha, India.

Sci Rep

2021 May 18

Kshatri JS, Bhattacharya D, Kanungo S

242. Pathologies affect the performance of ECG signals compression.

Sci Rep

2021 May 18

Nemcova A, Smisek R, Vitek M

243. Super-resolution imaging of platelet-activation process and its quantitative analysis.

Sci Rep

2021 May 18

Chung J, Jeong D, Kim GH

244. Simulation study on the mining conditions of dissolution of low grade solid potash ore in Qarhan Salt Lake.

Sci Rep

2021 May 18

Li R, Liu C, Jiao P

The output and grade of liquid potash minerals in Qarhan Salt Lake are decreasing year by year, which has become the main problem restricting the sustainable production of potassium fertilizer. The exploitation and utilization of low-grade solid potash ore, which is in the strata of the Qarhan Salt Lake, represents the fundamental framework for the sustainable development of Qarhan Salt Lake's potash fertilizer. PHREEQC is a simulation software for hydrogeochemistry. In this paper, PHREEQC was applied to simulate temperature, pH value and solvent chemical characteristics which affect the dissolution process of low-grade solid potash minerals. The simulation results indicate that the optimum temperature for ore dissolution is around 25 °C, because, around this temperature, the dissolving ability of solvents to low-grade solid potash minerals is enhanced, while the dissolving ability to halite remains basically unchanged, which is conducive to selective dissolution of low-grade solid potash. It is recommended the temperature is between 20 and 30 ℃. The simulation results show that, when the pH value of solvents is more than 9, although it is advantageous to selective dissolution of low-grade solid potash minerals, the solvent becomes strong alkali solution, which will cause environmental pollution and seriously corrode materials and equipment in actual production, so it is recommended the pH value of the solvent is adjusted between 6 and 8. The simulation results show that, when the values of K+, Na+, Mg2+, Ca2+, Cl- and SO42- in the solvent are 0.1%, 2.9%, 3.77%, 0.05%, 15.72% and 0.13% respectively, the solubility of low-grade solid potash ores is stronger, which is more conducive to selective ore dissolution. It is suggested that in actual production, the chemical composition of solvents prepared with old brine and fresh water should be as close as possible to the above chemical composition characteristics.

245. Inflammatory responses to metal oxide ceramic nanopowders.

Sci Rep

2021 May 18

Jamieson S, Mawdesley A, Deehan D

246. Highly stabilized flexible transparent capacitive photodetector based on silver nanowire/graphene hybrid electrodes.

Sci Rep

2021 May 18

Hwang Y(#), Hwang YH(#), Choi KW

247. Antibacterial activity and mechanism of plant flavonoids to gram-positive bacteria predicted from their lipophilicities.

Sci Rep

2021 May 18

Yuan G, Guan Y, Yi H

248. Delineating tesamorelin response pathways in HIV-associated NAFLD using a targeted proteomic and transcriptomic approach.

Sci Rep

2021 May 18

Fourman LT(#), Stanley TL(#), Billingsley JM

249. Analysis of the occurrence of hemophagocytic lymphohistiocytosis (HLH) features in patients with sepsis: a prospective study.

Sci Rep

2021 May 18

Bursa D, Bednarska A, Pihowicz A

250. Kokumi taste perception is functional in a model carnivore, the domestic cat (Felis catus).

Sci Rep

2021 May 18

Laffitte A(#), Gibbs M(#), Hernangomez de Alvaro C

251. Integrated metabolomic analysis and cytokine profiling define clusters of immuno-metabolic correlation in new-onset psoriasis.

Sci Rep

2021 May 18

Tarentini E, Odorici G, Righi V

252. STAT3 determines IL-4 signalling outcomes in naïve T cells.

Sci Rep

2021 May 18

Deimel LP, Li Z, Roy S

253. Factors affecting in-stent restenosis after angioplasty with the Enterprise stent for intracranial atherosclerotic diseases.

Sci Rep

2021 May 18

Zhang K(#), Li TX(#), Wang ZL

This study investigated factors affecting the safety and in-stent restenosis after intracranial stent angioplasty using the Enterprise stent for symptomatic intracranial atherosclerotic stenosis. Between January 2017 and March 2019, patients with intracranial atherosclerotic stenosis treated with Enterprise stent angioplasty were enrolled, including 400 patients in the modeling group and 89 patients in the validation group. The clinical factors affecting in-stent restenosis after Enterprise stent angioplasty in the modeling group were analyzed, and a logistic regression model of these factors was established and validated in the validation group. The receiver operating characteristic (ROC) curve and the area under the ROC curve (AUC) were analyzed. In the modeling group with 400 patients, there were 410 lesions, including 360 stenotic lesions and 50 occluded lesions, with 176 (42.9%) lesions in the anterior circulation and 234 (57.1%) in the posterior circulation. Successful stenting was performed in 398 patients (99.5%). Stenosis was significantly (P < 0.05) improved after stenting compared with before stenting (27.7% ± 2.9% vs. 77.9% ± 8.0%). Periprocedural complications included ischemic stroke (3.25%), hemorrhagic stroke (0.75%), and death (0.50%), with a total periprocedural complication rate of 4.0%. The first follow-up angiography was performed in 348 (87.0%) patients with 359 lesions 3.5-14 months (mean 5.7 months) after stenting. In-stent restenosis occurred in 62 (17.3%) lesions, while the other 295 (82.7%) had no restenosis. Lesion location, calcification degree, balloon expansion pressure, residual stenosis, intraprocedural dissection, and cerebral blood flow TICI grade were significant (P < 0.05) risk factors for in-stent restenosis. The in-stent restenosis prediction model was established as follows: P = 1/[1 + e-(-6.070-1.391 location + 2.745 calcification + 4.117 balloon inflation pressure + 2.195 intraprocedural dissection + 1.163 residual stenosis + 1.174 flow TC grade)]. In the validation group, the AUC in the ROC curve analysis was 0.902 (95% CI: 0.836-0.969), and when the cutoff value was 0.50, the sensitivity and specificity of this model were shown to be 76.92% and 80.26%, respectively, in predicting in-stent restenosis at angiographic follow-up, with a total coincidence rate of 79.78%. In conclusion, in-stent restenosis after intracranial Enterprise stenting is affected by stenosis location, calcification, balloon inflation pressure, intraprocedural arterial dissection, residual stenosis, and cerebral flow grade, and establishment of a logistic model with these factors can effectively predict in-stent restenosis.

254. Predicting anemia using NIR spectrum of spent dialysis fluid in hemodialysis patients.

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2021 May 18

Matović V, Jeftić B, Trbojević-Stanković J

255. Optimization of whole-brain rabies virus tracing technology for small cell populations.

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2021 May 17

Roelofs TJM, Menting-Henry S, Gol LM

256. Soil environmental quality in Nanling commodity grain base based on equal intercept transformation radar chart.

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2021 May 17

Dong HB, Zhang GH, Yan MJ

257. Dual RNA-seq analysis of in vitro infection multiplicity and RNA depletion methods in Chlamydia-infected epithelial cells.

Sci Rep

2021 May 17

Hayward RJ, Humphrys MS, Huston WM

258. iTRAQ-mediated analysis of the relationship between proteomic changes and yak longissimus lumborum tenderness over the course of postmortem storage.

Sci Rep

2021 May 17

Yang Y(#), Yang J(#), Ma J

259. Validity of the EOS-determined pelvic parameters and orientation with pelvic positional variation: a phantom study.

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2021 May 17

Kim JT, Lee DH, Lee HD

260. Increased expression of Protein S in eyes with diabetic retinopathy and diabetic macular edema.

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2021 May 17

Sugimoto M, Kondo M, Yasuma T

261. A miR-375/YAP axis regulates neuroendocrine differentiation and tumorigenesis in lung carcinoid cells.

Sci Rep

2021 May 17

Yang X(#), Nanayakkara J(#), Claypool D

262. Application of clove and dill oils as an alternative of salphos for chickpea food seed storage.

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2021 May 17

Kumar N, Khurana SMP, Pandey VN.

Mycological investigations of 25 samples of stored chickpea food seeds (Cicer arietinum L.) from grocery stores of Gurgaon and Gorakhpur revealed occurrence of seventeen fungal species belonging to genus viz., Alternaria, Aspergillus, Chaetomium, Colletotrichum, Curvularia, Fusarium, Penicillium, Rhizopus, Rhizoctonia, and Sclerotium. In these Aspergillus flavus, A. niger, Fusarium oxysporum had dominance in terms of per cent occurrence. Only one species of Bruchid (Callosobruchus chinensis L.) occurred in all the 25 samples. The biodeterioration of seeds inoculated with fungi: A. flavus, A. niger, F. oxysporum and the insect-C. chinensis, revealed their role in seed deterioration. For chickpea food seed protection essential oils were extracted from edible commodity(clove(Lavang and dill(sowa) leaf). Clove(Lavang) oil registered highest antifungal activity inhibiting (100%) mycelial growth of fungi, viz. species Aspergillus flavus, A. niger, Fusarium oxysporum at 300 ppm but was fungicidal at 400 ppm. Dill (Sowa) oil showed complete inhibition at 400 ppm and was fungicidal at 500 ppm. While mixture of both the oils (clove and dill) showed complete inhibition (100%) and fungicidal action at 400 ppm against the dominant fungi. The oils showed 100% insect repellent activity and were found fungicidal at 0.02 ml dose and also insecticidal. The mixture of oils was cidal at 0.02 ml dose. The mixture of oils showed a broad antifungal spectrum at 500 ppm while only 70-93% inhibitory activity at 300 ppm. The oils' mixture's activity was not affected by temp, storage and autoclaving up to 150 days. Oils physico-chemical properties were studied. GC-MS analysis of clove(Lavang) oil depicted major components: 75.63%eugenol while dill(sowa) leaf oil had 25.14% apiole. Formulation of Mixture of oils was more effective showing complete seed protection i.e.no growth of fungi and insects upto 150 days storage than salphos (150 days). While salphos controlled only maximum three fungi (A. terreus, C. dematium, F. moniliforme). The formulated oils mixture did not have any adverse effect on the chickpea seeds and increased their shelf life.

263. Genetic structure of urban and non-urban populations differs between two common parid species.

Sci Rep

2021 May 17

Markowski M, Minias P, Bańbura M

264. Disparities between IgG4-related kidney disease and extrarenal IgG4-related disease in a case-control study based on 450 patients.

Sci Rep

2021 May 17

Zeng Q(#), Gao J(#), Zhang X(#)

265. Comparative evaluation of the antioxidant, antimicrobial and nutritive properties of gluten-free flours.

Sci Rep

2021 May 17

Miedzianka J, Drzymała K, Nemś A

266. Discovery of primary prostate cancer biomarkers using cross cancer learning.

Sci Rep

2021 May 17

Zhou K, Arslanturk S, Craig DB

267. A high-efficiency method for site-directed mutagenesis of large plasmids based on large DNA fragment amplification and recombinational ligation.

Sci Rep

2021 May 17

Zhang K(#), Yin X(#), Shi K(#)

268. High 1-year risk of stroke in patients with hepatocellular carcinoma: a nationwide registry-based cohort study.

Sci Rep

2021 May 17

Hsu JY, Liu PP, Liu AB

269. Ultrasound-guided corticosteroid injection for patients with carpal tunnel syndrome: a systematic review and meta-analysis of randomized controlled trials.

Sci Rep

2021 May 17

Yang FA, Shih YC, Hong JP

270. CRISPR-mediated mutations in the ABC transporter gene ABCA2 confer pink bollworm resistance to Bt toxin Cry2Ab.

Sci Rep

2021 May 17

Fabrick JA, LeRoy DM, Mathew LG

271. LIPG endothelial lipase and breast cancer risk by subtypes.

Sci Rep

2021 May 17

Gago-Dominguez M, Redondo CM, Calaza M

Experimental data showed that endothelial lipase (LIPG) is a crucial player in breast cancer. However, very limited data exists on the role of LIPG on the risk of breast cancer in humans. We examined the LIPG-breast cancer association within our population-based case-control study from Galicia, Spain, BREOGAN (BREast Oncology GAlicia Network). Plasma LIPG and/or OxLDL were measured on 114 breast cancer cases and 82 controls from our case-control study, and were included in the present study. The risk of breast cancer increased with increasing levels of LIPG (multivariable OR for the highest category (95% CI) 2.52 (1.11-5.81), P-trend = 0.037). The LIPG-breast cancer association was restricted to Pre-menopausal breast cancer (Multivariable OR for the highest LIPG category (95% CI) 4.76 (0.94-28.77), P-trend = 0.06, and 1.79 (0.61-5.29), P-trend = 0.372, for Pre-menopausal and Post-menopausal breast cancer, respectively). The LIPG-breast cancer association was restricted to Luminal A breast cancers (Multivariable OR for the highest LIPG category (95% CI) 3.70 (1.42-10.16), P-trend = 0.015, and 2.05 (0.63-7.22), P-trend = 0.311, for Luminal A and non-Luminal A breast cancers, respectively). Subset analysis only based on HER2 receptor indicated that the LIPG-breast cancer relationship was restricted to HER2-negative breast cancers (Multivariable OR for the highest LIPG category (95% CI) 4.39 (1.70-12.03), P-trend = 0.012, and 1.10 (0.28-4.32), P-trend = 0.745, for HER2-negative and HER2-positive tumors, respectively). The LIPG-breast cancer association was restricted to women with high total cholesterol levels (Multivariable OR for the highest LIPG category (95% CI) 6.30 (2.13-20.05), P-trend = 0.018, and 0.65 (0.11-3.28), P-trend = 0.786, among women with high and low cholesterol levels, respectively). The LIPG-breast cancer association was also restricted to non-postpartum breast cancer (Multivariable OR for the highest LIPG category (95% CI) 3.83 (1.37-11.39), P-trend = 0.003, and 2.35 (0.16-63.65), P-trend = 0.396, for non-postpartum and postpartum breast cancer, respectively), although we lacked precision. The LIPG-breast cancer association was more pronounced among grades II and III than grade I breast cancers (Multivariable ORs for the highest category of LIPG (95% CI) 2.73 (1.02-7.69), P-trend = 0.057, and 1.90 (0.61-6.21), P-trend = 0.170, for grades II and III, and grade I breast cancers, respectively). No association was detected for OxLDL levels and breast cancer (Multivariable OR for the highest versus the lowest category (95% CI) 1.56 (0.56-4.32), P-trend = 0.457).

272. Outer membrane and phospholipid composition of the target membrane affect the antimicrobial potential of first- and second-generation lipophosphonoxins.

Sci Rep

2021 May 17

Látrová K, Havlová N, Večeřová R

273. Deciphering the laws of social network-transcendent COVID-19 misinformation dynamics and implications for combating misinformation phenomena.

Sci Rep

2021 May 17

Cheng M, Yin C, Nazarian S

274. Misalignment between perceptual boundaries and weight categories reflects a new normal for body size perception.

Sci Rep

2021 May 17

Chan AWY, Noles DL, Utkov N

275. Quantum transport in a single molecular transistor at finite temperature.

Sci Rep

2021 May 17

Kalla M, Chebrolu NR, Chatterjee A.

276. Maternal and perinatal factors are associated with risk of pediatric central nervous system tumors and poorer survival after diagnosis.

Sci Rep

2021 May 17

Adel Fahmideh M, Peckham-Gregory EC, Schraw JM

Central nervous system (CNS) tumors are the most common solid tumors in children. Findings on the role of maternal and perinatal factors on the susceptibility or outcome of these tumors are inconclusive. Therefore, we investigated the association between these early-life factors, risk, and survival of pediatric CNS tumors, using data from one of the world's largest and most diverse cancer registries. Information on pediatric CNS tumor cases (n = 1950) for the period 1995-2011 was obtained from the Texas Cancer Registry. Birth certificate controls were frequency-matched on birth year at a ratio of 10:1 for the same period. Evaluated maternal and perinatal variables were obtained from birth records. Unconditional logistic regression was used to generate adjusted odds ratios (ORs) and 95% confidence intervals (CIs) for etiological factors. Additionally, Cox proportional hazards regression was employed to assess adjusted hazard ratios (HRs) and 95% CIs for survival factors. The results indicated that Hispanic and non-Hispanic black mothers were less likely to have children with CNS tumors compared to non-Hispanic white mothers (OR 0.88 [95% CI 0.78-0.98] P-value = 0.019; OR 0.79 [95% CI 0.67-0.93 P-value = 0.004], respectively). Infants born large for gestational age (OR 1.26 [95% CI 1.07-1.47] P-value = 0.004) and those delivered pre-term (OR 1.19 [95% CI 1.04-1.38] P-value = 0.013) showed an increased risk of CNS tumors. Infants born by vaginal forceps or vacuum delivery had a higher risk of CNS tumors compared to those born by spontaneous vaginal delivery (OR 1.35 [95% CI 1.12-1.62] P-value = 0.002). Additionally, offspring of Hispanic and non-Hispanic black mothers showed a higher risk of death (HR 1.45 [95% CI 1.16-1.80] P-value = 0.001; HR 1.53 [95% CI 1.12-2.09] P-value = 0.008, respectively). Infants born by cesarean had a higher risk of death compared to those delivered vaginally (HR 1.28 [95% CI 1.05-1.57] P-value = 0.016). These findings indicate the important role of maternal and perinatal characteristics in the etiology and survival of these clinically significant malignancies.

277. Artificial intelligence could alert for focal skeleton/bone marrow uptake in Hodgkin's lymphoma patients staged with FDG-PET/CT.

Sci Rep

2021 May 17

Sadik M, López-Urdaneta J, Ulén J

278. Long-term conservation agriculture and best nutrient management improves productivity and profitability coupled with soil properties of a maize-chickpea rotation.

Sci Rep

2021 May 17

Pooniya V, Zhiipao RR, Biswakarma N

279. Resting state alpha oscillatory activity is a valid and reliable marker of schizotypy.

Sci Rep

2021 May 17

Trajkovic J, Di Gregorio F, Ferri F

280. Synthesizing environmentally friendly non-silicone oxygen bleaching stabilizer for linen yarn using oligomeric acrylic acid.

Sci Rep

2021 May 14

Liu J, Lv C.

281. Fungus-mediated green synthesis of nano-silver using Aspergillus sydowii and its antifungal/antiproliferative activities.

Sci Rep

2021 May 14

Wang D, Xue B, Wang L

282. Priming with skin-problems increases fear of clusters.

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2021 May 14

Shirai R, Ogawa H.

283. Effect of hypoxia factors gene silencing on ROS production and metabolic status of A375 malignant melanoma cells.

Sci Rep

2021 May 14

Špaková I, Rabajdová M, Mičková H

The innate response of melanocytes to exogenous or endogenous stress stimuli like extreme pH and temperature, metabolite and oxygen deficiency or a high UV dose initiates a cellular stress response. This process activates adaptive processes to minimize the negative impact of the stressor on the pigment cell. Under physiological conditions, a non-cancer cell is directed to apoptosis if the stressor persists. However, malignant melanoma cells will survive persistent stress thanks to distinct "cancerous" signaling pathways (e.g. MEK) and transcription factors that regulate the expression of so-called "survival genes" (e.g. HIF, MITF). In this survival response of cancer cells, MEK pathway directs melanoma cells to deregulate mitochondrial metabolism, to accumulate reduced species (NADH), and to centralize metabolism in the cytosol. The aim of this work was to study the effect of gene silencing in malignant melanoma A375 cells on metabolic processes in cytosol and mitochondria. Gene silencing of HIF-1α, and miR-210 in normoxia and pseudohypoxia, and analysis of its effect on MITF-M, and PDHA1 expression. Detection of cytosolic NADH by Peredox-mCherry Assay. Detection of OCR, and ECAR using Seahorse XF96. Measurement of produced O2•- with MitoTracker Red CMXRos. 1H NMR analysis of metabolites present in cell suspension, and medium. By gene silencing of HIF-1α and miR-210 the expression of PDHA1 was upregulated while that of MITF-M was downregulated, yielding acceleration of mitochondrial respiratory activity and thus elimination of ROS. Hence, we detected a significantly reduced A375 cell viability, an increase in alanine, inositol, nucleotides, and other metabolites that together define apoptosis. Based on the results of measurements of mitochondrial resipiratory activity, ROS production, and changes in the metabolites obtained in cells under the observed conditions, we concluded that silencing of HIF-1α and miR-210 yields apoptosis and, ultimately, apoptotic cell death in A375 melanoma cells.

284. Fast and accurate automated recognition of the dominant cells from fecal images based on Faster R-CNN.

Sci Rep

2021 May 14

Zhang J, Wang X, Ni G

285. Oil palm cultivation critically affects sociality in a threatened Malaysian primate.

Sci Rep

2021 May 14

Holzner A, Balasubramaniam KN, Weiß BM

286. In-vitro and in-vivo metabolism of different aspirin formulations studied by a validated liquid chromatography tandem mass spectrometry method.

Sci Rep

2021 May 14

Dei Cas M(#), Rizzo J(#), Scavone M

287. Differential features of chronic cough according to etiology and the simple decision tree for predicting causes.

Sci Rep

2021 May 14

Koo HK, Bae W, Moon JY

288. Omega-3 fatty acid-rich fish oil supplementation prevents rosiglitazone-induced osteopenia in aging C57BL/6 mice and in vitro studies.

Sci Rep

2021 May 14

Cugno C, Kizhakayil D, Calzone R

289. Molecular and serological epidemiology of Leptospira infection in cats in Okinawa Island, Japan.

Sci Rep

2021 May 14

Kakita T, Kuba Y, Kyan H

290. Radioactivity and radionuclides in deciduous teeth formed before the Fukushima-Daiichi Nuclear Power Plant accident.

Sci Rep

2021 May 14

Takahashi A, Chiba M, Tanahara A

291. Kaolin based protective barrier in municipal landfills against adverse chemo-mechanical loadings.

Sci Rep

2021 May 14

Das P, Bharat TV.

292. Micro-mechanical performance evaluation of expansive soil biotreated with indigenous bacteria using MICP method.

Sci Rep

2021 May 14

Tiwari N, Satyam N, Sharma M.

This study explored the effect of indigenous bacteria present in the soil to stabilized swelling behavior and improving the mechanical property of expansive soil. The objective of the research is to investigate the effectiveness of the biostimulation microbial induced calcite precipitation (MICP) for controlling the swelling-shrinkage behavior and improving shear strength of expansive soil. An attempt was made to develop an effective procedure to culture the indigenous bacteria for treating clays with varying plasticity and improve their engineering behavior. The detailed procedure has been investigated to effectively apply the MICP technique in clay soil, considering its low permeable nature. The applicability of biostimulation to clayey soils in minimizing their swelling potential and improving the strength is assessed. Both macroscale and microscale studies were conducted on untreated and biostimulated soils to observe changes in plasticity, strength, swelling, mineralogical, chemical characteristics. The present method has shown an effective alternative to improve the road pavement subgrade without affecting the eco-system of natural soil. The method investigated the effective way of providing the enrichment and cementation solution in clayey soil, which is the major concern in current literature. The study confirms that the calcite content has been increased with biostimulated MICP treatment up to 205% in the treated specimens and which future increased the unconfined compressive strength and split tensile strength. A reduction in the swelling pressure and swell strain is also observed. The results show that a cost-effect and eco-friendly method can be deployed for stabilizing the road pavement subgrades. The statistical assessment using multivariate analysis and hierarchical clustering dendrogram has been carried out to investigate the effect of the MICP treatment protocol on different soil and engineering parameters.

293. Accuracy of digital model generated from CT data with metal artifact reduction algorithm.

Sci Rep

2021 May 14

Lee C(#), Lee A(#), Choi YJ

294. Chorioamnionitis induces hepatic inflammation and time-dependent changes of the enterohepatic circulation in the ovine fetus.

Sci Rep

2021 May 14

Heymans C, den Dulk M, Lenaerts K

295. Room-temperature-superconducting T(c) driven by electron correlation.

Sci Rep

2021 May 14

Kim HT.

296. The influence of body position on bioelectrical impedance spectroscopy measurements in young children.

Sci Rep

2021 May 14

Lyons-Reid J, Ward LC, Tint MT

297. Development and comparison of novel bioluminescent mouse models of pancreatic neuroendocrine neoplasm metastasis.

Sci Rep

2021 May 13

Kaemmer CA, Umesalma S, Maharjan CK

298. Low ventilatory responsiveness to transient hypoxia or breath-holding predicts fast marathon performance in healthy middle-aged and older men.

Sci Rep

2021 May 13

Paleczny B, Seredyński R, Wyciszkiewicz M

The aim of this study was to test the utility of haemodynamic and autonomic variables (e.g. peripheral chemoreflex sensitivity [PCheS], blood pressure variability [BPV]) for the prediction of individual performance (marathon time and VO2max) in older men. The post-competition vasodilation and sympathetic vasomotor tone predict the marathon performance in younger men, but their prognostic relevance in older men remains unknown. The peripheral chemoreflex restrains exercise-induced vasodilation via sympathetically-mediated mechanism, what makes it a plausible candidate for the individual performance marker. 23 men aged ≥ 50 year competing in the Wroclaw Marathon underwent an evaluation of: resting haemodynamic parameters, PCheS with two methods: transient hypoxia and breath-holding test (BHT), cardiac barosensitivity, heart rate variability (HRV) and BPV, plasma renin and aldosterone, VO2max in a cardiopulmonary exercise test (CPET). All tests were conducted twice: before and after the race, except for transient hypoxia and CPET which were performed once, before the race. Fast marathon performance and high VO2max were correlated with: low ventilatory responsiveness to hypoxia (r = - 0.53, r = 0.67, respectively) and pre-race BHT (r = - 0.47, r = 0.51, respectively), (1) greater SD of beat-to-beat SBP (all p < 0.05). Fast performance was related with an enhanced pre-race vascular response to BHT (r = - 0.59, p = 0.005). The variables found by other studies to predict the marathon performance in younger men: post-competition vasodilation, sympathetic vasomotor tone (LF-BPV) and HRV were not associated with the individual performance in our population. The results suggest that PCheS (ventilatory response) predicts individual performance (marathon time and VO2max) in men aged ≥ 50 yeat. Although cause-effect relationship including the role of peripheral chemoreceptors in restraining the post-competition vasodilation via the sympathetic vasoconstrictor outflow may be hypothesized to underline these findings, the lack of correlation between individual performance and both, the post-competition vasodilation and the sympathetic vasomotor tone argues against such explanation. Vascular responsiveness to breath-holding appears to be of certain value for predicting individual performance in this population, however.

299. Improved efficiency of coding systems with health information technology.

Sci Rep

2021 May 13

Lee J, Choi JY.

300. An intact complement system dampens cornea inflammation during acute primary HSV-1 infection.

Sci Rep

2021 May 13

Filiberti A, Gmyrek GB, Berube AN

301. An assessment of the mathematical model for estimating of entropy optimized viscous fluid flow towards a rotating cone surface.

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2021 May 13

Li YM, Khan MI, Khan SA

302. Transient fixation of L4 vertebra preserves lumbar motion and function in Lenke Type 5C and 6C scoliosis.

Sci Rep

2021 May 13

Yang JH, Shin JW, Park SR

303. Quantitative determination of spin-orbit-induced magnetic field in GaMnAs by field-scan planar Hall measurements.

Sci Rep

2021 May 13

Park S(#), Lee S(#), Lee KJ

304. A screen of FDA-approved drugs identifies inhibitors of protein tyrosine phosphatase 4A3 (PTP4A3 or PRL-3).

Sci Rep

2021 May 13

Rivas DR(#), Dela Cerna MVC(#), Smith CN

305. Genetic dissection of heterosis of indica-japonica by introgression line, recombinant inbred line and their testcross populations.

Sci Rep

2021 May 13

Yang W(#), Zhang F(#), Zafar S(#)

306. Detecting the pulmonary trunk in CT scout views using deep learning.

Sci Rep

2021 May 13

Demircioğlu A(#), Stein MC(#), Kim MS

307. Inhibition of checkpoint kinase 1 potentiates anticancer activity of gemcitabine in bladder cancer cells.

Sci Rep

2021 May 13

Isono M, Okubo K, Asano T

308. The features of the coastal fronts in the Eastern Guangdong coastal waters during the downwelling-favorable wind period.

Sci Rep

2021 May 13

Yang C, Ye H.

309. Joint angle estimation with wavelet neural networks.

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2021 May 13

Sivakumar S, Gopalai AA, Lim KH

310. Lung function decline is associated with serum uric acid in Korean health screening individuals.

Sci Rep

2021 May 13

Ahn KM, Lee SY, Lee SH

311. Long-term results of sirolimus treatment in lymphangioleiomyomatosis: a single referral centre experience.

Sci Rep

2021 May 13

Revilla-López E, Berastegui C, Méndez A

312. Using past interglacial temperature maxima to explore transgressions in modern Maldivian coral and Amphistegina bleaching thresholds.

Sci Rep

2021 May 13

Stainbank S, Kroon D, de Leau ES

313. Faster monitoring of the invasive alien species (IAS) Dreissena polymorpha in river basins through isothermal amplification.

Sci Rep

2021 May 13

Carvalho J, Garrido-Maestu A, Azinheiro S

314. CMM-Net: Contextual multi-scale multi-level network for efficient biomedical image segmentation.

Sci Rep

2021 May 13

Al-Masni MA, Kim DH.

315. Spinal pain increases the risk of becoming overweight in Danish schoolchildren.

Sci Rep

2021 May 13

Hestbaek L, Aartun E, Côté P

316. TBC1D24 emerges as an important contributor to progressive postlingual dominant hearing loss.

Sci Rep

2021 May 13

Oziębło D, Leja ML, Lazniewski M

317. 3D modeling of a superconducting dynamo-type flux pump.

Sci Rep

2021 May 13

Ghabeli A, Pardo E, Kapolka M.

318. Profilin2 regulates actin rod assembly in neuronal cells.

Sci Rep

2021 May 13

Walter LM, Rademacher S, Pich A

319. A generative adversarial network-based abnormality detection using only normal images for model training with application to digital breast tomosynthesis.

Sci Rep

2021 May 13

Swiecicki A, Konz N, Buda M

320. In vitro performance of free and encapsulated bromelain.

Sci Rep

2021 May 13

Ataide JA, Cefali LC, Figueiredo MC

For centuries, bromelain has been used to treat a range of ailments, even though its mechanism of action is not fully understood. Its therapeutic benefits include enzymatic debridement of the necrotic tissues of ulcers and burn wounds, besides anti-inflammatory, anti-tumor, and antioxidant properties. However, the protease is unstable and susceptible to self-hydrolysis over time. To overcome the stability issues of bromelain, a previous study formulated chitosan-bromelain nanoparticles (C-B-NP). We evaluated the optimized nanoformulation for in vitro antioxidant, cell antiproliferative activities and cell migration/proliferation in the scratch assay, comparing it with free bromelain. The antioxidant activity of free bromelain was concentration and time-dependent; after encapsulation, the activity level dropped, probably due to the slow release of protein from the nanoparticles. In vitro antiproliferative activity was observed in six tumor cell lines for free protein after 48 h of treatment (glioma, breast, ovarian, prostate, colon adenocarcinoma and chronic myeloid leukemia), but not for keratinocyte cells, enabling its use as an active topical treatment. In turn, C-B-NP only inhibited one cell line (chronic myeloid leukemia) and required higher concentrations for inhibition. After 144 h treatment of glioma cells with C-B-NP, growth inhibition was equivalent to that promoted by the free protein. This last result confirmed the delayed-release kinetics of the optimized formulation and bromelain integrity. Finally, a scratch assay with keratinocyte cells showed that C-B-NP achieved more than 90% wound retraction after 24 h, compared to no retraction with the free bromelain. Therefore, nanoencapsulation of bromelain with chitosan conferred physical protection, delayed release, and wound retraction activity to the formulation, properties that favor topical formulations with a modified release. In addition, the promising results with the glioma cell line point to further studies of C-B-NP for anti-tumor treatments.

321. Screening of core filter layer for the development of respiratory mask to combat COVID-19.

Sci Rep

2021 May 13

Pandey LK, Singh VV, Sharma PK

322. In silico analysis suggests the RNAi-enhancing antibiotic enoxacin as a potential inhibitor of SARS-CoV-2 infection.

Sci Rep

2021 May 13

Ahmadi A, Moradi S.

323. Salt tolerance of selected halophytes at the two initial growth stages for future management options.

Sci Rep

2021 May 13

Alhaddad FA, Abu-Dieyeh MH, ElAzazi EM

324. An SIR-type epidemiological model that integrates social distancing as a dynamic law based on point prevalence and socio-behavioral factors.

Sci Rep

2021 May 13

Cabrera M(#), Córdova-Lepe F(#), Gutiérrez-Jara JP(#)

325. Response to novelty induced by change in size and complexity of familiar objects in Lister-Hooded rats, a follow-up of 2019 study.

Sci Rep

2021 May 13

Pisula W, Modlinska K, Chrzanowska A

326. Comparing physiological responses during cognitive tests in virtual environments vs. in identical real-world environments.

Sci Rep

2021 May 13

Kalantari S, Rounds JD, Kan J

327. A robust polyfunctional Pd(II)-based magnetic amphiphilic nanocatalyst for the Suzuki-Miyaura coupling reaction.

Sci Rep

2021 May 13

Aghahosseini H, Saadati MR, Rezaei SJT

328. Serum alanine aminotransferase as an early marker of outcomes in patients receiving anti-PD-1 or anti-CTLA-4 antibody.

Sci Rep

2021 May 13

Azuma T, Takeuchi T, Matayoshi Y

329. The effects of beta-cell mass and function, intercellular coupling, and islet synchrony on [Formula: see text] dynamics.

Sci Rep

2021 May 13

Saadati M, Jamali Y.

330. Total testosterone is not associated with lean mass or handgrip strength in pre-menopausal females.

Sci Rep

2021 May 13

Alexander SE, Abbott G, Aisbett B

331. On local intrinsic dimensionality of deformation in complex materials.

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2021 May 13

Zhou S, Tordesillas A, Pouragha M

332. Daily variation of macronutrient concentrations in mature human milk over 3 weeks.

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2021 May 13

Leghi GE, Lai CT, Narayanan A

333. Cumulative incidence and risk factors for radiation induced leukoencephalopathy in high grade glioma long term survivors.

Sci Rep

2021 May 13

Terziev R, Psimaras D, Marie Y

334. Distinct roles of tumor associated mutations in collective cell migration.

Sci Rep

2021 May 13

Lee RM, Vitolo MI, Losert W

335. A metallo-β-lactamase enzyme for internal detoxification of the antibiotic thienamycin.

Sci Rep

2021 May 12

Diene SM, Pinault L, Baron SA

336. Analysis of hip joint loading during walking with different shoe types using instrumented total hip prostheses.

Sci Rep

2021 May 12

Palmowski Y, Popović S, Kosack D

337. Multiview deconvolution approximation multiphoton microscopy of tissues and zebrafish larvae.

Sci Rep

2021 May 12

Kapsokalyvas D, Rosas R, Janssen RWA

338. Infection effects of the new microsporidian species Tubulinosema suzukii on its host Drosophila suzukii.

Sci Rep

2021 May 12

Biganski S, Fückel S, Jehle JA

339. Abiraterone acetate versus bicalutamide in combination with gonadotropin releasing hormone antagonist therapy for high risk metastatic hormone sensitive prostate cancer.

Sci Rep

2021 May 12

Ueda T, Shiraishi T, Ito S

340. Hearing brain evaluated using near-infrared spectroscopy in congenital toxoplasmosis.

Sci Rep

2021 May 12

Bertachini ALL(#), Januario GC(#), Novi SL

341. Affective empathy predicts self-isolation behaviour acceptance during coronavirus risk exposure.

Sci Rep

2021 May 12

Petrocchi S(#), Bernardi S, Malacrida R

342. Predicting distribution of malaria vector larval habitats in Ethiopia by integrating distributed hydrologic modeling with remotely sensed data.

Sci Rep

2021 May 12

Jiang AL, Lee MC, Zhou G

343. The lower respiratory tract microbiome of critically ill patients with COVID-19.

Sci Rep

2021 May 12

Gaibani P, Viciani E, Bartoletti M

344. Comparison of bipolar plasmakinetic resection of prostate versus photoselective vaporization of prostate by a three year retrospective observational study.

Sci Rep

2021 May 12

Cheng X(#), Qin C(#), Xu P

345. Molecular docking analysis and evaluation of the antibacterial and antioxidant activities of the constituents of Ocimum cufodontii.

Sci Rep

2021 May 12

Aliye M, Dekebo A, Tesso H

346. Paracetamol (acetaminophen) rescues cognitive decline, neuroinflammation and cytoskeletal alterations in a model of post-operative cognitive decline (POCD) in middle-aged rats.

Sci Rep

2021 May 12

Garrone B, Durando L, Prenderville J

347. Novel vocalizations are understood across cultures.

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2021 May 12

Ćwiek A, Fuchs S, Draxler C

348. COVID-19's natural course among ambulatory monitored outpatients.

Sci Rep

2021 May 12

Weinbergerova B(#), Mayer J(#), Hrabovsky S

Research objective was to detail COVID-19's natural trajectory in relation to the Czech population's viral load. Our prospective detailed daily questionnaire-based telemonitoring study evaluated COVID-19's impact among 105 outpatients. In accordance with government quarantine requirements, outpatients were divided into a cohort with two negative tests at the end of the disease (40 patients) and a cohort with a new algorithm (65 patients) following a 14-day quarantine. Median follow-up differed significantly between the 2 groups (23 days vs. 16 days). Only 6% of patients were asymptomatic during the entire telemonitoring period. Another 13% of patients were diagnosed asymptomatic, as suspected contacts, yet later developed symptoms, while the remaining 81% were diagnosed as symptomatic on average 6 days following symptom onset. Telemonitoring enabled precise symptom status chronicling. The most frequently reported complaints were fevers, respiratory issues, and anosmia. Six patients were eventually hospitalized for complications detected early after routine telemonitoring. During the extended follow-up (median 181 days), anosmia persisted in 26% of patients. 79% of patients in the new quarantine algorithm cohort reported no symptoms on day 11 compared to just 56% of patients in the two negative test cohort upon first testing negative (median-19 days). The highest viral load occurred within 0-2 days of initial symptom onset. Both the PCR viral load and two consecutive PCR negative sample realizations indicated high interindividual variability with a surprisingly fluctuating pattern among 43% of patients. No definitive COVID-19 symptoms or set of symptoms excepting anosmia (59%) and/or ageusia (47%) were identified. No preexisting medical conditions specifically foreshadowed disease trajectory in a given patient. Without a PCR negativity requirement for quarantine cessation, patients could exhibit fewer symptoms. Our study therefore highlights the urgent need for routine ambulatory patient telemedicine monitoring, early complication detection, intensive mass education connecting disease demeanor with subsequent swift diagnostics, and, notably, the need to reevaluate and modify quarantine regulations for better control of SARS-CoV-2 proliferation.

349. A discovery about the positional distribution pattern among candidate homologous pixels and its potential application in aerial multi-view image matching.

Sci Rep

2021 May 12

Zhang K, Xiao W(#), Sheng Y

350. Role of miR-506 in ulcerative colitis associated with primary sclerosing cholangitis.

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2021 May 12

Kempinska-Podhorodecka A, Adamowicz M, Ostrycharz E

351. Body temperature and esthesia in individuals with stroke.

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2021 May 12

da Silva Dias C, Alfieri FM, Dos Santos ACA

352. Revealing the activation mechanism of autoinhibited RalF by integrated simulation and experimental approaches.

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2021 May 12

Dudas B, Perahia D, Balog E.

353. Rayleigh-wave attenuation across the conterminous United States in the microseism frequency band.

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2021 May 12

Magrini F, Boschi L, Gualtieri L

354. Clinical course and risk factors of fatal adverse outcomes in COVID-19 patients in Korea: a nationwide retrospective cohort study.

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2021 May 12

Song J, Park DW, Cha JH

355. C646 inhibits G2/M cell cycle-related proteins and potentiates anti-tumor effects in pancreatic cancer.

Sci Rep

2021 May 12

Ono H, Kato T, Murase Y

356. Stray light characterization with ultrafast time-of-flight imaging.

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2021 May 12

Clermont L, Uhring W, Georges M.

357. Great tits who remember more accurately have difficulty forgetting, but variation is not driven by environmental harshness.

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2021 May 12

Hermer E, Murphy B, Chaine AS

358. Spatial and temporal analysis of cumulative environmental effects of offshore wind farms in the North Sea basin.

Sci Rep

2021 May 12

Gușatu LF, Menegon S, Depellegrin D

359. Real-world rogue wave probabilities.

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2021 May 12

Häfner D, Gemmrich J, Jochum M.

360. Intracellular localization of the mycobacterial stressosome complex.

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2021 May 12

Ramesh M, Nitharwal RG, Behra PRK

361. Effect of various weight loss interventions on serum NT-proBNP concentration in severe obese subjects without clinical manifest heart failure.

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2021 May 12

Hollstein T, Schlicht K, Krause L

362. The force effects of two types of polyethylene terephthalate glyc-olmodified clear aligners immersed in artificial saliva.

Sci Rep

2021 May 12

Xiang B, Wang X, Wu G

363. Global optimization of an encapsulated Si/SiO[Formula: see text] L3 cavity with a 43 million quality factor.

Sci Rep

2021 May 12

Vasco JP, Savona V.

364. Functional display of bioactive peptides on the vGFP scaffold.

Sci Rep

2021 May 12

Chee SMQ, Wongsantichon J, Yi LS

365. Monotonous driving induces shifts in spatial attention as a function of handedness.

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2021 May 12

Chandrakumar D, Coussens S, Keage HAD

366. Human monocyte-derived type 1 and 2 macrophages recognize Ara h 1, a major peanut allergen, by different mechanisms.

Sci Rep

2021 May 12

Krause M, Crauwels P, Blanco-Pérez F

367. Simulating the computational mechanisms of cognitive and behavioral psychotherapeutic interventions: insights from active inference.

Sci Rep

2021 May 12

Smith R, Moutoussis M(#), Bilek E(#).

368. GWAS analysis reveals distinct pathogenicity profiles of Australian Parastagonospora nodorum isolates and identification of marker-trait-associations to septoria nodorum blotch.

Sci Rep

2021 May 12

Phan HTT, Furuki E, Hunziker L

369. Strong anisotropic enhancement of photoluminescence in WS(2) integrated with plasmonic nanowire array.

Sci Rep

2021 May 12

Han C, Wang Y, Zhou W

370. Holocene polynya dynamics and their interaction with oceanic heat transport in northernmost Baffin Bay.

Sci Rep

2021 May 12

Jackson R, Kvorning AB, Limoges A

371. A randomised, non-inferiority study of chloroprocaine 2% and ropivacaine 0.75% in ultrasound-guided axillary block.

Sci Rep

2021 May 11

Sulyok I, Camponovo C, Zotti O

372. Mortality after large artery occlusion acute ischemic stroke.

Sci Rep

2021 May 11

Karamchandani RR, Rhoten JB, Strong D

373. Canonical Hamiltonian ensemble representation of dephasing dynamics and the impact of thermal fluctuations on quantum-to-classical transition.

Sci Rep

2021 May 11

Chen HB, Chen YN.

374. The feasibility of Gazefinder under 12 months of age infants.

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2021 May 11

Fukushima S, Takahashi T, Tsukamoto K

375. Identification of linear epitopes on the flagellar proteins of Clostridioides difficile.

Sci Rep

2021 May 11

Razim A, Pacyga K, Naporowski P

376. Genome-wide simple sequence repeats (SSR) markers discovered from whole-genome sequence comparisons of multiple spinach accessions.

Sci Rep

2021 May 11

Bhattarai G, Shi A, Kandel DR

377. Importance of [Formula: see text] orbital and electron correlation in iron-based superconductors revealed by phase diagram for 1111-system.

Sci Rep

2021 May 11

Kawashima T, Miyasaka S, Tsuji H

378. The SoftWipe tool and benchmark for assessing coding standards adherence of scientific software.

Sci Rep

2021 May 11

Zapletal A(#), Höhler D(#), Sinz C

379. Thermoelectric transports in pristine and functionalized boron phosphide monolayers.

Sci Rep

2021 May 11

Li MS, Mo DC, Lyu SS.

380. Analysis of microbiota in the stomach and midgut of two penaeid shrimps during probiotic feeding.

Sci Rep

2021 May 11

Imaizumi K, Tinwongger S, Kondo H

381. Tiny, ornamented eggs and eggshell from the Upper Cretaceous of Utah represent a new ootaxon with theropod affinities.

Sci Rep

2021 May 11

Oser SE, Chin K, Sertich JJW

382. Surgical outcomes of localization using indocyanine green fluorescence in breast conserving surgery: a prospective study.

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2021 May 11

Lee EG(#), Kim SK(#), Han JH

383. Efficient multiscale calculation results for microchannel mass transfer.

Sci Rep

2021 May 11

Zhang Y.

384. Utilization of urea and chicken litter biochar to improve rice production.

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2021 May 11

Maikol N, Haruna AO, Maru A

385. Safety measures for COVID-19 do not compromise the outcomes of patients undergoing primary percutaneous coronary intervention: a single center retrospective study.

Sci Rep

2021 May 11

Guan X, Zhang J, Li Y

Coronavirus disease 2019 (COVID-19) is a global pandemic impacting nearly 170 countries/regions and millions of patients worldwide. Patients with acute myocardial infarction (AMI) still need to be treated at percutaneous coronary intervention (PCI) centers with relevant safety measures. This retrospective study was conducted to assess the therapeutic outcomes of PCI performed under the safety measures and normal conditions. AMI patients undergoing PCI between January 24 to April 30, 2020 were performed under safety measures for COVID-19. Patients received pulmonary computed tomography (CT) and underwent PCI in negative pressure ICU. Cardiac catheterization laboratory (CCL) staff and physicians worked with level III personal protection. Demographic and clinical data, such as door-to-balloon (DTB) time, operation time, complications for patients in this period (COVID-19 group) and the same period in 2019 (2019 group) were retrieved and analyzed. COVID-19 and 2019 groups had 37 and 96 patients, respectively. There was no significant difference in age, gender, BMI and comorbidity between the two groups. DTB time and operation time were similar between the two groups (60.0 ± 12.39 vs 58.83 ± 12.85 min, p = 0.636; 61.46 ± 9.91 vs 62.55 ± 10.72 min, p = 0.592). Hospital stay time in COVID-19 group was significantly shorter (6.78 ± 2.14 vs 8.85 ± 2.64 days, p < 0.001). The incidences of malignant arrhythmia and Takotsubo Syndrome in COVID-19 group were higher than 2019 group significantly (16.22% vs 5.21%, p = 0.039; 10.81% vs 1.04% p = 0.008). During hospitalization and 3-month follow-up, the incidence of major adverse cardiovascular events and mortality in the two groups were statistically similar (35.13% vs 14.58%, p = 0.094; 16.22% vs 8.33%, p = 0.184). The risk of major adverse cardiac events (MACE) was associated with cardiogenic shock (OR, 11.53; 95% CI, 2.888-46.036; p = 0.001), malignant arrhythmias (OR, 7.176; 95% CI, 1.893-27.203; p = 0.004) and advanced age (≥ 75 years) (OR, 6.718; 95% CI, 1.738-25.964; p = 0.006). Cardiogenic shock (OR, 17.663; 95% CI, 5.5-56.762; p < 0.001) and malignant arrhythmias (OR, 4.659; 95% CI, 1.481-14.653; p = 0.008) were also associated with death of 3 months. Our analysis showed that safety measures undertaken in this hospital, including screening of COVID-19 infection and use of personal protection equipment for conducting PCI did not compromise the surgical outcome as compared with PCI under normal condition, although there were slight increases in incidence of malignant arrhythmia and Takotsubo Syndrome.

386. Reduced competence to arboviruses following the sustainable invasion of Wolbachia into native Aedes aegypti from Southeastern Brazil.

Sci Rep

2021 May 11

Gesto JSM(#), Ribeiro GS(#), Rocha MN(#)

387. Numerical simulation of spatiotemporal red blood cell aggregation under sinusoidal pulsatile flow.

Sci Rep

2021 May 11

Lee CA, Paeng DG.

388. Semiparametric model selection for identification of environmental covariates related to adult groundfish catches and weights.

Sci Rep

2021 May 11

Correia HE.

389. Comparison of anthropometric and body composition indices in the identification of metabolic risk factors.

Sci Rep

2021 May 11

Lee BJ, Yim MH.

390. DNA methylation landscape of 16 canine somatic tissues by methylation-sensitive restriction enzyme-based next generation sequencing.

Sci Rep

2021 May 11

Yamazaki J, Matsumoto Y, Jelinek J

391. Metformin improves the outcomes in Chinese invasive breast cancer patients with type 2 diabetes mellitus.

Sci Rep

2021 May 11

Hui T(#), Shang C(#), Yang L

392. QUBO formulations for training machine learning models.

Sci Rep

2021 May 11

Date P, Arthur D, Pusey-Nazzaro L.

393. Acute toxicity analysis of an inhibitor of BCL2, Disarib, in rats.

Sci Rep

2021 May 11

Sharma S, Varsha KK, Ray U

Apoptosis or programmed cell death is a highly regulated process, which eliminates unwanted and damaged cells. Inhibition of apoptosis is a hallmark of cancer cells. BCL2 family proteins are known to play a vital role in the regulation of apoptosis. Overexpression of BCL2, an antiapoptotic protein, provides the advantage of prolonged survival to cancer cells. Over the years, several BCL2 inhibitors have been investigated extensively for their anticancer potential. However, most of them were abolished before clinical use due to their side effects. Previously, we had identified and characterized a novel BCL2 inhibitor, Disarib, with the potential to eliminate tumor cells in a BCL2 specific manner leading to reduction in tumor burden in multiple mouse models. Notably, a head-to-head comparison of Disarib to ABT199, the only FDA approved BCL2 inhibitor revealed that Disarib is as potent as ABT199. Recent studies using mice revealed that Disarib did not invoke significant side effects in mice. In the present study, we have investigated the acute toxicity of Disarib in Wistar rats. The bioavailability studies following exposure of Disarib in Wistar rats revealed its maximum availability in serum at 24 h following oral administration. Acute toxicity analysis revealed that even a dose as high as 2000 mg/kg of Disarib did not cause significant toxicity in rats. There was no significant variation in blood parameters or kidney and liver functions following administration of Disarib. Histological analysis of different tissues from Disarib treated groups revealed standard architecture with no observable cellular damage. Importantly, exposure to Diasrib did not result in genotoxicity as determined by micronucleus assay. Further, solubility assays revealed that besides DMSO, Disarib is also soluble in alcohol. While the high acidic condition can increase the solubility of Disarib, even a lower percentage of alcohol with acidic conditions can improve its solubility. Thus, the toxicological profile in the current study revealed no significant side effects when Disarib was administered orally to rats.

394. Co-incorporation of manure and inorganic fertilizer improves leaf physiological traits, rice production and soil functionality in a paddy field.

Sci Rep

2021 May 11

Iqbal A, He L, Ali I

395. Associations among perfluorooctanesulfonic/perfluorooctanoic acid levels, nuclear receptor gene polymorphisms, and lipid levels in pregnant women in the Hokkaido study.

Sci Rep

2021 May 11

Kobayashi S, Sata F, Goudarzi H

396. Radiomics-based neural network predicts recurrence patterns in glioblastoma using dynamic susceptibility contrast-enhanced MRI.

Sci Rep

2021 May 11

Shim KY(#), Chung SW(#), Jeong JH(#)

397. Phenotypical predictors of pregnancy-related restless legs syndrome and their association with basal ganglia and the limbic circuits.

Sci Rep

2021 May 11

Chechko N, Lefort-Besnard J, Goecke TW

398. IDH2 mutations in patients with normal karyotype AML predict favorable responses to daunorubicin, cytarabine and cladribine regimen.

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2021 May 11

Libura M, Bialopiotrowicz E, Giebel S

399. First comprehensive quantification of annual land use/cover from 1990 to 2020 across mainland Vietnam.

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2021 May 11

Phan DC, Trung TH, Truong VT

400. Mechanisms of halosulfuron methyl pesticide biosorption onto neem seeds powder.

Sci Rep

2021 May 11

Haq AU, Saeed M, Usman M

401. Alkalinity of diverse water samples can be altered by mercury preservation and borosilicate vial storage.

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2021 May 11

Mos B, Holloway C, Kelaher BP

402. Field studies on breeding sites of Culicoides LATREILLE (Diptera: Ceratopogonidae) in agriculturally used and natural habitats.

Sci Rep

2021 May 11

Kameke D, Kampen H, Wacker A

403. Delineating visual, auditory and motor regions in the human brain with functional neuroimaging: a BrainMap-based meta-analytic synthesis.

Sci Rep

2021 May 11

Heckner MK, Cieslik EC, Küppers V

404. Novel AI driven approach to classify infant motor functions.

Sci Rep

2021 May 10

Reich S(#), Zhang D(#), Kulvicius T

405. MRI- and histologically derived neuroanatomical atlas of the Ambystoma mexicanum (axolotl).

Sci Rep

2021 May 10

Lazcano I, Cisneros-Mejorado A, Concha L

406. Relationship of contact angle of spray solution on leaf surfaces with weed control.

Sci Rep

2021 May 10

da Silva Santos RT, Vechia JFD, Dos Santos CAM

The weeds are important in agricultural and livestock areas because these plants can cause several damages, especially in the yield. The herbicide pulverization for weed control is the most used, but the efficiency of the control can be dependent the several factors, for example, the correct chose the herbicide and the mixture or not with adjuvant. This study aimed to evaluate the contact angle of herbicide solution droplets associated with adjuvant when deposited on the leaf surface of different weed species and their relationship with chemical control. For the contact angle experiment, the design was completely randomized, with four repetitions, while for the control experiment, a randomized block design was used, both experiments were arranged in a factorial (4 × 2 + 1) design. Factor A corresponded to four spray solutions containing the herbicide no addition of adjuvants and herbicide associated with adjuvants (vegetable oil, mineral oil, and lecithin), factor B to two herbicide dosages, and additional treatment corresponded to water. The contact angle was determined in six weed species: Crotalaria incana, Lantana camara, Ipomoea grandifolia, Asclepias curassavica, Sida obtusifolia, and Ricinus communis, on the adaxial and abaxial surface of each species, and an artificial surface. For the weed control experiment was used two weed species: C. incana and L. camara. The multivariate analysis allowed the understanding of the behavior of the contact angle of the different groups on the natural and artificial surfaces, due to the formation of factors. For all plants, except for the abaxial surface of I. grandifolia and the adaxial surface of A. curassavica, the association of herbicide and adjuvants reduced contact angle on the surfaces. The chemical control resulted in an indirect relation with contact angle, where smaller contact angles of the herbicide solution resulted in a higher percentage of plant intoxication. Therefore, for this situation, it is recommended to use the herbicide aminopyralid + fluroxypir associated with lecithin.

407. Development of a Loop-mediated isothermal amplification (LAMP) technique for specific and early detection of Mycobacterium leprae in clinical samples.

Sci Rep

2021 May 10

Garg N, Sahu U, Kar S

408. Effects of cadmium stress on growth and physiological characteristics of sassafras seedlings.

Sci Rep

2021 May 10

Zhao H, Guan J, Liang Q

The effects of cadmium stress on the growth and physiological characteristics of Sassafras tzumu Hemsl. were studied in pot experiments. Five Cd levels were tested [CT(Control Treatment) : 0 mg/kg, Cd5: 5 mg/kg, Cd20: 20 mg/kg, Cd50: 50 mg/kg, and Cd100: 100 mg/kg]. The growth and physiological characteristics of the sassafras seedlings in each level were measured. The results showed that soil Cd had negative influences on sassafras growth and reduced the net growth of plant height and the biomass of leaf, branch and root. Significant reductions were recorded in root biomass by 18.18%(Cd5), 27.35%(Cd20), 27.57%(Cd50) and 28.95%(Cd100). The contents of hydrogen peroxide decreased first then increased while malondialdehyde showed the opposite trend with increasing cadmium concentration. Decreases were found in hydrogen peroxide contents by 10.96%(Cd5), 11.82%(Cd20) and 7.02%(Cd50); increases were found in malondialdehyde contents by 15.47%(Cd5), 16.07%(Cd20) and 7.85%(Cd50), indicating that cadmium stress had a certain effect on the peroxidation of the inner cell membranes in the seedlings that resulted in damage to the cell membrane structure. Superoxide dismutase activity decreased among treatments by 17.05%(Cd5), 10,68%(Cd20), 20.85%(Cd50) and 8.91%(Cd100), while peroxidase activity increased steadily with increasing cadmium concentration; these results suggest that peroxidase is likely the main protective enzyme involved in the reactive oxygen removal system in sassafras seedlings. Upward trends were observed in proline content by 90.76%(Cd5), 74.36%(Cd20), 99.73%(Cd50) and 126.01%(Cd100). The increase in proline content with increasing cadmium concentration indicated that cadmium stress induced proline synthesis to resist osmotic stress in the seedlings. Compared to that in CT, the soluble sugar content declined under the different treatments by 32.84%(Cd5), 5.85%(Cd20), 25.55%(Cd50) and 38.69%(Cd100). Increases were observed in the soluble protein content by 2.34%(Cd5), 21.36%(Cd20), 53.15%(Cd50) and 24.22%(Cd100). At different levels of cadmium stress, the chlorophyll content in the seedlings first increased and then decreased, and it was higher in the Cd5 and Cd20 treatments than that in the CT treatment. These results reflected that cadmium had photosynthesis-promoting effects at low concentrations and photosynthesis-suppressing effects at high concentrations. The photosynthetic gas exchange parameters and photosynthetic light-response parameters showed downward trends with increasing cadmium concentration compared with those in CT; these results reflected the negative effects of cadmium stress on photosynthesis in sassafras seedlings.

409. Spatial heterogeneity of hepatic fibrosis in primary sclerosing cholangitis vs. viral hepatitis assessed by MR elastography.

Sci Rep

2021 May 10

Reiter R, Shahryari M, Tzschätzsch H

410. Psychosis risk individuals show poor fitness and discrepancies with objective and subjective measures.

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2021 May 10

Damme KSF, Sloan RP, Bartels MN

411. Development and characterization of two equine formulations towards SARS-CoV-2 proteins for the potential treatment of COVID-19.

Sci Rep

2021 May 10

León G, Herrera M, Vargas M

412. Effects of the depth of the acetabular component during simulated acetabulum reaming in total hip arthroplasty.

Sci Rep

2021 May 10

Zuo J(#), Xu M(#), Zhao X(#)

413. Formulation and evaluation of injectable dextran sulfate sodium nanoparticles as a potent antibacterial agent.

Sci Rep

2021 May 10

Madkhali OA, Sivagurunathan Moni S, Sultan MH

414. Biomechanical regulation of breast cancer metastasis and progression.

Sci Rep

2021 May 10

Spencer A(#), Sligar AD(#), Chavarria D

415. Improving radiologist's ability in identifying particular abnormal lesions on mammograms through training test set with immediate feedback.

Sci Rep

2021 May 10

Trieu PDY, Lewis SJ, Li T

It has been shown that there are differences in diagnostic accuracy of cancer detection on mammograms, from below 50% in developing countries to over 80% in developed world. One previous study reported that radiologists from a population in Asia displayed a low mammographic cancer detection of 48% compared with over 80% in developed countries, and more importantly, that most lesions missed by these radiologists were spiculated masses or stellate lesions. The aim of this study was to explore the performance of radiologists after undertaking a training test set which had been designed to improve the capability in detecting a specific type of cancers on mammograms. Twenty-five radiologists read two sets of 60 mammograms in a standardized mammogram reading room. The first test set focused on stellate or spiculated masses. When radiologists completed the first set, the system displayed immediate feedback to the readers comparing their performances in each case with the truth of cancer cases and cancer types so that the readers could identify individual-based errors. Later radiologists were asked to read the second set of mammograms which contained different types of cancers including stellate/spiculated masses, asymmetric density, calcification, discrete mass and architectural distortion. Case sensitivity, lesion sensitivity, specificity, receiver operating characteristics (ROC) and Jackknife alternative free-response receiver operating characteristics (JAFROC) were calculated for each participant and their diagnostic accuracy was compared between two sessions. Results showed significant improvement among radiologists in case sensitivity (+ 11.4%; P < 0.05), lesion sensitivity (+ 18.7%; P < 0.01) and JAFROC (+ 11%; P < 0.01) in the second set compared with the first set. The increase in diagnostic accuracy was also recorded in the detection of stellate/spiculated mass (+ 20.6%; P < 0.05). This indicated that the performance of radiologists in detecting malignant lesions on mammograms can be improved if an appropriate training intervention is applied after the readers' weakness and strength are identified.

416. An enhanced dual IDW method for high-quality geospatial interpolation.

Sci Rep

2021 May 10

Li Z.

417. Regulatory rare variants of the dopaminergic gene ANKK1 as potential risk factors for Parkinson's disease.

Sci Rep

2021 May 10

Pérez-Santamarina E, García-Ruiz P, Martínez-Rubio D

418. Methylmercury induces neuronal cell death by inducing TNF-α expression through the ASK1/p38 signaling pathway in microglia.

Sci Rep

2021 May 10

Toyama T, Hoshi T, Noguchi T

419. The cytochrome P450 (CYP) superfamily in cnidarians.

Sci Rep

2021 May 10

Pankov KV, McArthur AG, Gold DA

420. Elevated serum SDMA and ADMA at hospital admission predict in-hospital mortality of COVID-19 patients.

Sci Rep

2021 May 10

Hannemann J(#), Balfanz P(#), Schwedhelm E

421. Peering inside a cough or sneeze to explain enhanced airborne transmission under dry weather.

Sci Rep

2021 May 10

Liu K, Allahyari M, Salinas JS

422. Bortezomib induces methylation changes in neuroblastoma cells that appear to play a significant role in resistance development to this compound.

Sci Rep

2021 May 10

Łuczkowska K(#), Sokolowska KE(#), Taryma-Lesniak O

423. Numerical study of nano-biofilm stagnation flow from a nonlinear stretching/shrinking surface with variable nanofluid and bioconvection transport properties.

Sci Rep

2021 May 10

Alsenafi A, Bég OA, Ferdows M

A mathematical model is developed for stagnation point flow toward a stretching or shrinking sheet of liquid nano-biofilm containing spherical nano-particles and bioconvecting gyrotactic micro-organisms. Variable transport properties of the liquid (viscosity, thermal conductivity, nano-particle species diffusivity) and micro-organisms (species diffusivity) are considered. Buongiorno's two-component nanoscale model is deployed and spherical nanoparticles in a dilute nanofluid considered. Using a similarity transformation, the nonlinear systems of partial differential equations is converted into nonlinear ordinary differential equations. These resulting equations are solved numerically using a central space finite difference method in the CodeBlocks Fortran platform. Graphical plots for the distribution of reduced skin friction coefficient, reduced Nusselt number, reduced Sherwood number and the reduced local density of the motile microorganisms as well as the velocity, temperature, nanoparticle volume fraction and the density of motile microorganisms are presented for the influence of wall velocity power-law index (m), viscosity parameter [Formula: see text], thermal conductivity parameter (c4), nano-particle mass diffusivity (c6), micro-organism species diffusivity (c8), thermophoresis parameter [Formula: see text], Brownian motion parameter [Formula: see text], Lewis number [Formula: see text], bioconvection Schmidt number [Formula: see text], bioconvection constant (σ) and bioconvection Péclet number [Formula: see text]. Validation of the solutions via comparison related to previous simpler models is included. Further verification of the general model is conducted with the Adomian decomposition method (ADM). Extensive interpretation of the physics is included. Skin friction is elevated with viscosity parameter ([Formula: see text] whereas it is suppressed with greater Lewis number and thermophoresis parameter. Temperatures are elevated with increasing thermal conductivity parameter ([Formula: see text] whereas Nusselt numbers are reduced. Nano-particle volume fraction (concentration) is enhanced with increasing nano-particle mass diffusivity parameter ([Formula: see text]) whereas it is markedly reduced with greater Lewis number (Le) and Brownian motion parameter (Nb). With increasing stretching/shrinking velocity power-law exponent ([Formula: see text] skin friction is decreased whereas Nusselt number and Sherwood number are both elevated. Motile microorganism density is boosted strongly with increasing micro-organism diffusivity parameter ([Formula: see text]) and Brownian motion parameter (Nb) but reduced considerably with greater bioconvection Schmidt number (Sc) and bioconvection Péclet number (Pe). The simulations find applications in deposition processes in nano-bio-coating manufacturing processes.

Newmer生物

Newmer生物