生信网-文献期刊

Sci Rep

2021 Jul 9

Vallittu PK, Varrela J, Salo J

2. Perception of geometric sequences and numerosity both predict formal geometric competence in primary school children.

Sci Rep

2021 Jul 9

Castaldi E(#), Arrighi R(#), Cicchini GM

3. Head-nodding: a driving force for the circulation of cerebrospinal fluid.

Sci Rep

2021 Jul 9

Xu Q(#), Shao CX(#), Zhang Y(#)

The myodural bridge (MDB) is a dense connective tissue bridge connecting the suboccipital muscles to the spinal dura mater, and it has been proven to be a normal common existing structure in humans and mammals. Some scholars believe that the suboccipital muscles can serve as a dynamic cerebrospinal fluid (CSF) pump via the MDB, and they found head rotations promote the CSF flow in human body, which provided evidence for this hypothesis. Head movement is a complex motion, but the effects of other forms of head movement on CSF circulation are less known. The present study explored the effects of head-nodding on CSF circulation. The CSF flow of 60 healthy volunteers was analyzed via cine phase-contrast magnetic resonance imaging at the level of the occipitocervical junction before and after one-minute-head-nodding period. Furthermore, the CSF pressures of 100 volunteers were measured via lumbar puncture before and after 5 times head-nodding during their anesthetizing for surgical preparation. As a result, it was found that the maximum and average CSF flow rates at the level of the upper border of atlas during ventricular diastole were significantly decreased from 1.965 ± 0.531 to 1.839 ± 0.460 ml/s and from 0.702 ± 0.253 to 0.606 ± 0.228 ml/s respectively. In the meantime, the changes in the ratio of cranial and caudal orientation of the net flow volume were found differed significantly after the one-minute-head-nodding period (p = 0.017). And on the other hand, the CSF pressures at the L3-L4 level were markedly increased 116.03 ± 26.13 to 124.64 ± 26.18 mmH2O. In conclusion, the head-nodding has obvious effects on CSF circulation and head movement is one of the important drivers of cerebrospinal fluid circulation. We propose that the suboccipital muscles, participating in various head movements, might pull the dura sac via the myodural bridge, and thus, head movement provides power for the CSF circulation.

4. Detection of Begomovirus in chilli and tomato plants using functionalized gold nanoparticles.

Sci Rep

2021 Jul 9

Lavanya R, Arun V.

5. Effective silencing of miR-126 after ischemic stroke by means of intravenous α-tocopherol-conjugated heteroduplex oligonucleotide in mice.

Sci Rep

2021 Jul 9

Suzuki M, Ishibashi S, Iwasawa E

6. Feasibility of balloon-based endobiliary radiofrequency ablation under cholangioscopy guidance in a swine model.

Sci Rep

2021 Jul 9

Inoue T, Kutsumi H, Ibusuki M

7. Experimental demonstration of a concave grating for spin waves in the Rowland arrangement.

Sci Rep

2021 Jul 9

Papp Á(#), Kiechle M(#), Mendisch S

8. Differences in the level of physical fitness and mobility among older women with osteoporosis and healthy women-cross-sectional study.

Sci Rep

2021 Jul 9

Babiuch AS, Oestervemb K, Lipińska A

9. Differential polarization and activation dynamics of systemic T helper cell subsets after aneurysmal subarachnoid hemorrhage (SAH) and during post-SAH complications.

Sci Rep

2021 Jul 9

Chaudhry SR, Kahlert UD, Kinfe TM

Aneurysmal subarachnoid hemorrhage (SAH) is associated with high morbidity and mortality. Devastating post-SAH complications, such as cerebral vasospasm (CVS), delayed cerebral ischemia or seizures to mention a few, are mainly responsible for the poor clinical outcome. Inflammation plays an indispensable role during early brain injury (EBI) and delayed brain injury (DBI) phases over which these complications arise. T helper cells are the major cytokine secreting cells of adaptive immunity that can polarize to multiple functionally unique sub-populations. Here, we investigate different CD4+ T cell subsets during EBI and DBI phases after SAH, and their dynamics during post-SAH complications. Peripheral venous blood from 15 SAH patients during EBI and DBI phases, was analyzed by multicolour flowcytometry. Different subsets of CD3+ CD4+ T cells were characterized by differential cell surface expression of CXCR3 and CCR6 into Th1, Th2, Th17, whereas Tregs were defined by CD25hiCD127lo. The analysis of activation states was done by the expression of stable activation markers CD38 and HLA-DR. Interestingly, compared to healthy controls, Tregs were significantly increased during both EBI and DBI phases. Different activation states of Tregs showed differential significant increase during EBI and DBI phases compared to controls. HLA-DR- CD38+ Tregs were significantly increased during DBI phase compared to EBI phase in SAH patients developing CVS, seizures and infections. However, HLA-DR- CD38- Tregs were significantly reduced during EBI phase in patients with cerebral ischemia (CI) compared to those without CI. HLA-DR- CD38- Th2 cells were significantly increased during EBI phase compared to controls. A significant reduction in Th17/Tregs and HLA-DR- CD38+ Th17/Tregs ratios was observed during both EBI and DBI phases compared to controls. While HLA-DR- CD38- Th17/Tregs and HLA-DR- CD38- Th1/Th2 ratios were impaired only during EBI phase compared to controls. In conclusion, CD4+ T cell subsets display dynamic and unique activation patterns after SAH and during the course of the manifestation of post-SAH complications, which may be helpful for the development of precision neurovascular care. However, to claim this, confirmatory studies with larger patient cohorts, ideally from different ethnic backgrounds, are required. Moreover, our descriptive study may be the grounds for subsequent lab endeavors to explore the underlying mechanisms of our observations.

10. Levosimendan increases brain tissue oxygen levels after cardiopulmonary resuscitation independent of cardiac function and cerebral perfusion.

Sci Rep

2021 Jul 9

García-Bardon A, Kamuf J, Ziebart A

11. Stratigraphy of stable isotope ratios and leaf structure within an African rainforest canopy with implications for primate isotope ecology.

Sci Rep

2021 Jul 9

Lowry BE, Wittig RM, Pittermann J

12. Broadband radar invisibility with time-dependent metasurfaces.

Sci Rep

2021 Jul 9

Kozlov V, Vovchuk D, Ginzburg P.

13. Morphological, molecular characterization, plant pathogenicity and biocontrol of Cladosporium complex groups associated with faba beans.

Sci Rep

2021 Jul 9

El-Dawy EGAEM, Gherbawy YA, Hussein MA.

14. Direct RT-PCR amplification of SARS-CoV-2 from clinical samples using a concentrated viral lysis-amplification buffer prepared with IGEPAL-630.

Sci Rep

2021 Jul 9

Castellanos-Gonzalez A, Shelite TR, Lloyd N

15. In vitro protein digestibility and biochemical characteristics of soaked, boiled and fermented soybeans.

Sci Rep

2021 Jul 9

Ketnawa S, Ogawa Y.

16. A novel bidirectional clustering algorithm based on local density.

Sci Rep

2021 Jul 9

Lyu B, Wu W, Hu Z.

17. The stability of paintings and the molecular structure of the oil paint polymeric network.

Sci Rep

2021 Jul 9

Nardelli F, Martini F, Lee J

18. Correlation of image quality parameters with tube voltage in X-ray dark-field chest radiography: a phantom study.

Sci Rep

2021 Jul 8

Sauter AP(#), Andrejewski J(#), Frank M

19. Integrative analysis of key candidate genes and signaling pathways in acute coronary syndrome related to obstructive sleep apnea by bioinformatics.

Sci Rep

2021 Jul 8

Shi Y(#), Jiang Z(#), Jiang L

20. The electronic origins of the "rare earth" texture effect in magnesium alloys.

Sci Rep

2021 Jul 8

Mahjoub R, Stanford N.

21. Differential effects of body mass index on domain-specific cognitive outcomes after stroke.

Sci Rep

2021 Jul 8

Lee M, Oh MS, Jung S

22. Easy and quick (EQ) sperm freezing method for urgent preservation of mouse strains.

Sci Rep

2021 Jul 8

Mochida K(#), Hasegawa A(#), Shikata D

23. CPT to RVU conversion improves model performance in the prediction of surgical case length.

Sci Rep

2021 Jul 8

Garside N(#), Zaribafzadeh H(#), Henao R

24. Phytochemical composition and antioxidant properties of methanolic extracts of whole and dehulled Bambara groundnut (Vigna subterranea) seeds.

Sci Rep

2021 Jul 8

Adedayo BC, Anyasi TA, Taylor MJC

25. Effects of brewing conditions on infusible fluoride levels in tea and herbal products and probabilistic health risk assessment.

Sci Rep

2021 Jul 8

Pattaravisitsate N, Phetrak A, Denpetkul T

26. Screening of the HBx transactivation domain interacting proteins and the function of interactor Pin1 in HBV replication.

Sci Rep

2021 Jul 8

Zhou Q(#), Yan L(#), Xu B

27. Fuzzy rank-based fusion of CNN models using Gompertz function for screening COVID-19 CT-scans.

Sci Rep

2021 Jul 8

Kundu R, Basak H, Singh PK

28. Mapping habitat suitability for Asiatic black bear and red panda in Makalu Barun National Park of Nepal from Maxent and GARP models.

Sci Rep

2021 Jul 8

Su H, Bista M, Li M.

Habitat evaluation is essential for managing wildlife populations and formulating conservation policies. With the rise of innovative powerful statistical techniques in partnership with Remote Sensing, GIS and GPS techniques, spatially explicit species distribution modeling (SDM) has rapidly grown in conservation biology. These models can help us to study habitat suitability at the scale of the species range, and are particularly useful for examining the overlapping habitat between sympatric species. Species presence points collected through field GPS observations, in conjunction with 13 different topographic, vegetation related, anthropogenic, and bioclimatic variables, as well as a land cover map with seven classification categories created by support vector machine (SVM) were used to implement Maxent and GARP ecological niche models. With the resulting ecological niche models, the suitable habitat for asiatic black bear (Ursus thibetanus) and red panda (Ailurus fulgens) in Nepal Makalu Barun National Park (MBNP) was predicted. All of the predictor variables were extracted from freely available remote sensing and publicly shared government data resources. The modeled results were validated by using an independent dataset. Analysis of the regularized training gain showed that the three most important environmental variables for habitat suitability were distance to settlement, elevation, and mean annual temperature. The habitat suitability modeling accuracy, characterized by the mean area under curve, was moderate for both species when GARP was used (0.791 for black bear and 0.786 for red panda), but was moderate for black bear (0.857), and high for red panda (0.920) when Maxent was used. The suitable habitat estimated by Maxent for black bear and red panda was 716 km2 and 343 km2 respectively, while the suitable area determined by GARP was 1074 km2 and 714 km2 respectively. Maxent predicted that the overlapping area was 83% of the red panda habitat and 40% of the black bear habitat, while GARP estimated 88% of the red panda habitat and 58% of the black bear habitat overlapped. The results of land cover exhibited that barren land covered the highest percentage of area in MBNP (36.0%) followed by forest (32.6%). Of the suitable habitat, both models indicated forest as the most preferred land cover for both species (63.7% for black bear and 61.6% for red panda from Maxent; 59.9% black bear and 58.8% for red panda from GARP). Maxent outperformed GARP in terms of habitat suitability modeling. The black bear showed higher habitat selectivity than red panda. We suggest that proper management should be given to the overlapping habitats in the buffer zone. For remote and inaccessible regions, the proposed methods are promising tools for wildlife management and conservation, deserving further popularization.

29. Transcriptome analysis discloses dysregulated genes in normal appearing tumor-adjacent thyroid tissues from patients with papillary thyroid carcinoma.

Sci Rep

2021 Jul 8

He H(#), Liyanarachchi S(#), Li W

30. Implications of Tamarkoz on stress, emotion, spirituality and heart rate.

Sci Rep

2021 Jul 8

Bahadorani N, Lee JW, Martin LR.

31. Quantifying superspreading for COVID-19 using Poisson mixture distributions.

Sci Rep

2021 Jul 8

Kremer C(#), Torneri A(#), Boesmans S

32. Dysregulation of anti-Mullerian hormone expression levels in mural granulosa cells of FMR1 premutation carriers.

Sci Rep

2021 Jul 8

Friedman-Gohas M, Orvieto R, Michaeli A

33. Integrative taxonomy and phylogeography of Telenomus remus (Scelionidae), with the first record of natural parasitism of Spodoptera spp. in Brazil.

Sci Rep

2021 Jul 8

Wengrat APGS, Coelho Junior A, Parra JRP

34. Early prediction of neoadjuvant chemotherapy response by exploiting a transfer learning approach on breast DCE-MRIs.

Sci Rep

2021 Jul 8

Comes MC, Fanizzi A, Bove S

35. Unconventional Hall effect and its variation with Co-doping in van der Waals Fe(3)GeTe(2).

Sci Rep

2021 Jul 8

Chowdhury RR, DuttaGupta S, Patra C

36. Retrospective review of 27 European cases of fatal elephant endotheliotropic herpesvirus-haemorrhagic disease reveals evidence of disseminated intravascular coagulation.

Sci Rep

2021 Jul 8

Perrin KL, Kristensen AT, Bertelsen MF

37. Acute fat loss does not affect bone mass.

Sci Rep

2021 Jul 8

Lagerquist MK, Gustafsson KL, Henning P

38. Spatiotemporal sensitivity of mesoderm specification to FGFR signalling in the Drosophila embryo.

Sci Rep

2021 Jul 8

Yadav V, Tolwinski N, Saunders TE.

39. BiPSim: a flexible and generic stochastic simulator for polymerization processes.

Sci Rep

2021 Jul 8

Fischer S, Dinh M, Henry V

40. The value of autopsy in preterm infants at a Swedish tertiary neonatal intensive care unit 2002-2018.

Sci Rep

2021 Jul 8

Hoffsten A, Markasz L, Ericson K

41. Pre-harvest spray of GABA and spermine delays postharvest senescence and alleviates chilling injury of gerbera cut flowers during cold storage.

Sci Rep

2021 Jul 8

Mohammadi M, Aelaei M, Saidi M.

42. Stability analysis of the coexistence equilibrium of a balanced metapopulation model.

Sci Rep

2021 Jul 8

Rao S, Muyinda N, De Baets B.

43. A momentary assessment study on emotional and biological stress in adult males and females with autism spectrum disorder.

Sci Rep

2021 Jul 8

van der Linden K, Simons C, Viechtbauer W

44. The ammonia oxidizing bacterium Nitrosomonas eutropha blocks T helper 2 cell polarization via the anti-inflammatory cytokine IL-10.

Sci Rep

2021 Jul 8

Maura D, Elmekki N, Goddard CA.

45. New evidence of arsenic translocation and accumulation in Pteris vittata from real-time imaging using positron-emitting (74)As tracer.

Sci Rep

2021 Jul 8

Kohda YH, Qian Z, Chien MF

46. Adverse perinatal outcomes and its associated factors among adult and advanced maternal age pregnancy in Northwest Ethiopia.

Sci Rep

2021 Jul 7

Getaneh T, Asres A, Hiyaru T

Even though reduction of neonatal mortality is needed to achieve Sustainable Development Goals 2030, advanced maternal age is still an independent and a substantial risk factor for different adverse perinatal outcomes, in turn causes neonatal morbidity and mortality. In Ethiopia, research has validated that advanced maternal age is a significant factor in adverse perinatal outcomes, but researches which addressed or estimated its adverse perinatal outcomes are limited, reported inconsistent result and specifically no study was done in the study area. Therefore, this study was aimed to compare adverse perinatal outcomes and its associated factors among women with adult and advanced maternal age pregnancy in Northwest Ethiopia. Comparative cross-sectional study was conducted in Awi Zone, public hospitals, Northwest Ethiopia. Systematic random sampling was employed to select 348 adult and 176 advanced aged pregnant women. Structured questionnaire were used to collect the data. The collected data were analyzed using Statistical Package for the Social Sciences version 25. Binary and multivariate logistic regressions were fitted to assess the association between adverse perinatal outcomes and explanatory variables. P-value less than 0.05 was used to declare statistical significance. Significant percentage of advanced aged women (29.1%) had adverse perinatal outcomes compared to (14.5%) adult aged women. Similarly, proportion low birth weight, preterm birth and low Apgar score were significantly higher among advanced maternal age. The odds of composite adverse perinatal outcomes were higher among advanced maternal age women when compared to adult aged women (AOR 2.01, 95% CI 1.06, 3.79). No formal education (AOR 2.75, 95% CI 1.27, 5.95), short birth interval (AOR 2.25, 95% CI 1.07, 4.73) and complications during pregnancy (AOR 2.12, 95% CI 1.10, 4.10) were also factors significantly associated with adverse perinatal outcomes. Being advanced maternal age is at higher risk for adverse perinatal outcomes compared to adult aged women. Maternal illiteracy, short birth interval and complications during pregnancy were also significantly associated with adverse perinatal outcomes. Access of equal education, provision of family planning and perinatal care (including early detection and management of complication) is recommended.

47. Reversal of senescence-associated beta-galactosidase expression during in vitro three-dimensional tissue-engineering of human chondrocytes in a polymer scaffold.

Sci Rep

2021 Jul 7

Katoh S, Fujimaru A, Iwasaki M

48. Algorithm based on one monocular video delivers highly valid and reliable gait parameters.

Sci Rep

2021 Jul 7

Azhand A, Rabe S, Müller S

49. Drying and temperature induced conformational changes of nucleic acids and stallion sperm chromatin in trehalose preservation formulations.

Sci Rep

2021 Jul 7

Brogna R, Fan J, Sieme H

50. BeEAM conditioning regimen is a safe, efficacious and economical alternative to BEAM chemotherapy.

Sci Rep

2021 Jul 7

Hahn L, Lim H, Dusyk T

51. Calmodulin-dependent KCNE4 dimerization controls membrane targeting.

Sci Rep

2021 Jul 7

Roig SR, Solé L, Cassinelli S

52. Preoperative nomogram for microvascular invasion prediction based on clinical database in hepatocellular carcinoma.

Sci Rep

2021 Jul 7

Mao S, Yu X, Yang Y

53. Effects of education, income, and occupation on prevalence and symptoms of knee osteoarthritis.

Sci Rep

2021 Jul 7

Lee JY, Han K, Park YG

54. Antibiotics modulate neoadjuvant therapy efficiency in patients with breast cancer: a pilot analysis.

Sci Rep

2021 Jul 7

Zhang X, Yu L, Shi J

Mounting evidence suggests that microbiota dysbiosis caused by antibiotic administration is a risk factor for cancer, but few research reports focus on the relationships between antibiotics and chemotherapy efficiency. We evaluated the influence of antibiotic administration on neoadjuvant therapy efficacy in patients with breast cancer (BC) in the present study. BC patients were stratified into two groups: antibiotic-treated and control based on antibiotic administration within 30 days after neoadjuvant therapy initiation. Disease-free survival (DFS) and overall survival (OS) were assessed using the Kaplan-Meier method, and the Cox proportional hazards model was used for multivariate analyses. The pathologic complete response rate of the control group was significantly higher than that of the antibiotic-treated group (29.09% vs. 10.20%, p = 0.017). Further univariate analysis with Kaplan-Meier calculations demonstrated that antibiotic administration was strongly linked with both reduced DFS (p = 0.04) at significant statistical levels and OS (p = 0.088) at borderline statistical levels. Antibiotic administration was identified as a significant independent prognostic factor for DFS [hazard ratio (HR) 3.026, 95%, confidence interval (CI) 1.314-6.969, p = 0.009] and OS (HR 2.836, 95% CI 1.016-7.858, p = 0.047) by Cox proportional hazards model analysis. Antibiotics that initiated reduced efficiency of chemotherapy were more noticeable in the HER2-positive subgroup for both DFS (HR 5.51, 95% CI 1.77-17.2, p = 0.003) and OS (HR 7.0395% CI 1.94-25.53, p = 0.003), as well as in the T3-4 subgroup for both DFS (HR 20.36, 95% CI 2.41-172.07, p = 0.006) and OS (HR 13.45, 95% CI 1.39-130.08, p = 0.025) by stratified analysis. Antibiotic administration might be associated with reduced efficacy of neoadjuvant therapy and poor prognosis in BC patients. As a preliminary study, our research made preparations for further understanding and large-scale analyses of the impact of antibiotics on the efficacy of neoadjuvant therapy.

55. Geochemical characterization and assessment of fluoride sources in groundwater of Siloam area, Limpopo Province, South Africa.

Sci Rep

2021 Jul 7

Onipe T, Edokpayi JN, Odiyo JO.

56. Subthreshold electrical stimulation as a low power electrical treatment for stroke rehabilitation.

Sci Rep

2021 Jul 7

Kim K(#), Yoo SJ(#), Kim SY

57. Taphonomic and spatial analyses from the Early Pleistocene site of Venta Micena 4 (Orce, Guadix-Baza Basin, southern Spain).

Sci Rep

2021 Jul 7

Luzón C, Yravedra J, Courtenay LA

58. SoxD transcription factor deficiency in Schwann cells delays myelination in the developing peripheral nervous system.

Sci Rep

2021 Jul 7

Ittner E(#), Hartwig AC(#), Elsesser O

59. Comprehensive assessment of myocardial remodeling in ischemic heart disease by synchrotron propagation based X-ray phase contrast imaging.

Sci Rep

2021 Jul 7

Planinc I(#), Garcia-Canadilla P(#), Dejea H(#)

60. Label-free two-photon imaging of mitochondrial activity in murine macrophages stimulated with bacterial and viral ligands.

Sci Rep

2021 Jul 7

Allen CH, Ahmed D, Raiche-Tanner O

61. Paternal and maternal long-term psychological outcomes after uterine artery embolization for severe post-partum hemorrhage.

Sci Rep

2021 Jul 7

Bernasconi M(#), Eggel-Hort B(#), Horsch A

62. Oropharyngeal cancer patient stratification using random forest based-learning over high-dimensional radiomic features.

Sci Rep

2021 Jul 7

Patel H, Vock DM, Marai GE

63. Life cycle assessment of edible insects (Protaetia brevitarsis seulensis larvae) as a future protein and fat source.

Sci Rep

2021 Jul 7

Nikkhah A, Van Haute S, Jovanovic V

64. Pilot study quantifying muscle glycosaminoglycan using bi-exponential T(1ρ) mapping in patients with muscle stiffness after stroke.

Sci Rep

2021 Jul 6

Menon RG, Raghavan P, Regatte RR.

65. Innovative finding of 266-nm laser regulating CD90 levels in SDSCs.

Sci Rep

2021 Jul 6

Hsiao RL, Chen YC, Huang MY

66. Phenotypic and genetic variation of ultraviolet-visible-infrared spectral wavelengths of bovine meat.

Sci Rep

2021 Jul 6

Bittante G, Savoia S, Cecchinato A

67. Enhancement of aragonite mineralization with a chelating agent for CO(2) storage and utilization at low to moderate temperatures.

Sci Rep

2021 Jul 6

Wang J, Watanabe N, Inomoto K

68. Characterisation of mass distributions of solvent-fractionated lignins using analytical ultracentrifugation and size exclusion chromatography methods.

Sci Rep

2021 Jul 6

Lu Y, Joosten L, Donkers J

Lignins are valuable renewable resources for the potential production of a large array of biofuels, aromatic chemicals and biopolymers. Yet native and industrial lignins are complex, highly branched and heterogenous macromolecules, properties that have to date often undermined their use as starting materials in lignin valorisation strategies. Reliable knowledge of weight average molar mass, conformation and polydispersity of lignin starting materials can be proven to be crucial to and improve the prospects for the success of such strategies. Here we evaluated the use of commonly-used size exclusion chromatography (SEC)-calibrated with polystyrene sulphonate standards-and under-used analytical ultracentrifugation-which does not require calibration-to characterise a series of lignin fractions sequentially extracted from soda and Kraft alkaline lignins using ethyl acetate, methyl ethyl ketone (MEK), methanol and acetone:water (fractions F01-F04, respectively). Absolute values of weight average molar mass (Mw) determined using sedimentation equilibrium in the analytical ultracentrifuge of (3.0 ± 0.1) kDa and (4.2 ± 0.2) kDa for soda and Kraft lignins respectively, agreed closely with previous SEC-determined Mws and reasonably with the size exclusion chromatography measurements employed here, confirming the appropriateness of the standards (with the possible exceptions of fraction F05 for soda P1000 and F03 for Indulin). Both methods revealed the presence of low (~ 1 kDa) Mw material in F01 and F02 fractions followed by progressively higher Mw in subsequent fractions. Compositional analysis confirmed > 90% (by weight) total lignins successively extracted from both lignins using MEK, methanol and acetone:water (F02 to F04). Considerable heterogeneity of both unfractionated and fractionated lignins was revealed through determinations of both sedimentation coefficient distributions and polydispersity indices. The study also demonstrates the advantages of using analytical ultracentrifugation, both alongside SEC as well as in its own right, for determining absolute Mw, heterogeneity and conformation information for characterising industrial lignins.

69. Prediction of optimal continuous positive airway pressure in Thai patients with obstructive sleep apnea.

Sci Rep

2021 Jul 6

Saiphoklang N, Leelasittikul K, Pugongchai A.

70. Identification and comparative expression analysis of odorant-binding proteins in the reproductive system and antennae of Athetis dissimilis.

Sci Rep

2021 Jul 6

Song YQ, Song ZY, Dong JF

71. Nigella sativa callus treated with sodium azide exhibit augmented antioxidant activity and DNA damage inhibition.

Sci Rep

2021 Jul 6

Iqbal MS, Iqbal Z, Hashem A

Nigella sativa L. (NS) is an herbaceous plant, possessing phytochemicals of therapeutic importance. Thymoquinone is one of the active phytochemicals of NS that confers noteworthy antioxidant properties. Sodium azide, an agent of abiotic stress, can modulates antioxidant system in plants. In the present investigation, sodium azide (0, 5 µM, 10 µM, 20 µM, 50 µM, 100 µM and 200 µM) doses administered to the in vitro NS callus cultures for production/modification of secondary metabolites with augmented activity. 200 µM sodium azide treated NS callus exhibited maximum peroxidase activity (1.286 ± 0.101 nanokatal mg-1 protein) and polyphenol oxidase activity (1.590 ± 0.110 nanokatal mg-1 protein), while 100 µM sodium azide treated NS callus for optimum catalase activity (1.250 ± 0.105 nanokatal mg-1 protein). Further, 200 µM sodium azide treated NS callus obtained significantly the highest phenolics (3.666 ± 0.475 mg g-1 callus fresh weight), 20 µM sodium azide treated NS callus, the highest flavonoids (1.308 ± 0.082 mg g-1 callus fresh weight) and 100 µM sodium azide treated NS callus, the highest carotenes (1.273 ± 0.066 mg g-1 callus fresh weight). However, NS callus exhibited a decrease in thymoquinone yield/content vis-à-vis possible emergence of its analog with 5.3 min retention time and an increase in antioxidant property. Treatment with 200 µM sodium azide registered significantly the lowest percent yield of callus extract (4.6 ± 0.36 mg g-1 callus fresh weight) and thymoquinone yield (16.65 ± 2.52 µg g-1 callus fresh weight) and content (0.36 ± 0.07 mg g-1 callus dry weight) and the highest antioxidant activity (3.873 ± 0.402%), signifying a negative correlation of the former with the latter. DNA damage inhibition (24.3 ± 1.7%) was recorded significantly maximum at 200 µM sodium azide treatment. Sodium azide treated callus also recorded emergence of a new peak at 5.3 min retention time (possibly an analog of thymoquinone with augmented antioxidant activity) whose area exhibits significantly negative correlation with callus extract yield and thymoquinone yield/content and positive correlation with antioxidant activity and in vitro DNA damage inhibition. Thus, sodium azide treatment to NS callus confers possible production of secondary metabolites or thymoquinone analog (s) responsible for elevated antioxidant property and inhibition to DNA damage. The formation of potent antioxidants through sodium azide treatment to NS could be worthy for nutraceutical and pharmaceutical industries.

72. Apixaban concentration variability and relation to clinical outcomes in real-life patients with atrial fibrillation.

Sci Rep

2021 Jul 6

Mavri A, Vene N, Božič-Mijovski M

73. Untangling the genetic link between type 1 and type 2 diabetes using functional genomics.

Sci Rep

2021 Jul 6

Nyaga DM, Vickers MH, Jefferies C

There is evidence pointing towards shared etiological features between type 1 diabetes (T1D) and type 2 diabetes (T2D) despite both phenotypes being considered genetically distinct. However, the existence of shared genetic features for T1D and T2D remains complex and poorly defined. To better understand the link between T1D and T2D, we employed an integrated functional genomics approach involving extensive chromatin interaction data (Hi-C) and expression quantitative trait loci (eQTL) data to characterize the tissue-specific impacts of single nucleotide polymorphisms associated with T1D and T2D. We identified 195 pleiotropic genes that are modulated by tissue-specific spatial eQTLs associated with both T1D and T2D. The pleiotropic genes are enriched in inflammatory and metabolic pathways that include mitogen-activated protein kinase activity, pertussis toxin signaling, and the Parkinson's disease pathway. We identified 8 regulatory elements within the TCF7L2 locus that modulate transcript levels of genes involved in immune regulation as well as genes important in the etiology of T2D. Despite the observed gene and pathway overlaps, there was no significant genetic correlation between variant effects on T1D and T2D risk using European ancestral summary data. Collectively, our findings support the hypothesis that T1D and T2D specific genetic variants act through genetic regulatory mechanisms to alter the regulation of common genes, and genes that co-locate in biological pathways, to mediate pleiotropic effects on disease development. Crucially, a high risk genetic profile for T1D alters biological pathways that increase the risk of developing both T1D and T2D. The same is not true for genetic profiles that increase the risk of developing T2D. The conversion of information on genetic susceptibility to the protein pathways that are altered provides an important resource for repurposing or designing novel therapies for the management of diabetes.

74. The effect of deadlines on cancer screening completion: a randomized controlled trial.

Sci Rep

2021 Jul 6

Lieberman A, Gneezy A, Berry E

75. Statistical modeling for bioconvective tangent hyperbolic nanofluid towards stretching surface with zero mass flux condition.

Sci Rep

2021 Jul 6

Shafiq A, Lone SA, Sindhu TN

76. Triggering avalanches by transverse perturbations in a rotating drum.

Sci Rep

2021 Jul 6

Salinas V, Quiñinao C, González S

77. Association of peripheral anterior synechiae with anterior segment parameters in eyes with primary angle closure glaucoma.

Sci Rep

2021 Jul 6

Loo Y, Tun TA, Vithana EN

78. Both T cell priming in lymph node and CXCR3-dependent migration are the key events for predicting the response of atezolizumab.

Sci Rep

2021 Jul 6

Iwai T, Sugimoto M, Patil NS

79. Repeat and single dose administration of gadodiamide to rats to investigate concentration and location of gadolinium and the cell ultrastructure.

Sci Rep

2021 Jul 6

Davies J, Marino M, Smith APL

80. Metagenomic analysis of a throat swab sample collected in China on a patient infected with Varicella Zoster Virus.

Sci Rep

2021 Jul 6

Guo H(#), Rivailler P(#), Wang J

81. Prediction of non-responsiveness to pre-dialysis care program in patients with chronic kidney disease: a retrospective cohort analysis.

Sci Rep

2021 Jul 6

King EK, Hsieh MH, Chang DR

82. Effect of glycerol plasticizer loading on the physical, mechanical, thermal, and barrier properties of arrowroot (Maranta arundinacea) starch biopolymers.

Sci Rep

2021 Jul 6

Tarique J, Sapuan SM, Khalina A.

83. Secret messaging with endogenous chemistry.

Sci Rep

2021 Jul 6

Kennedy E, Geiser J, Arcadia CE

84. Enhancement of the thermoelectric properties in bilayer graphene structures induced by Fano resonances.

Sci Rep

2021 Jul 6

Briones-Torres JA, Pérez-Álvarez R, Molina-Valdovinos S

Fano resonances of bilayer graphene could be attractive for thermoelectric devices. The special profile presented by such resonances could significantly enhance the thermoelectric properties. In this work, we study the thermoelectric properties of bilayer graphene single and double barrier structures. The barrier structures are typically supported by a substrate and encapsulated by protecting layers, reducing considerably the phonon thermal transport. So, we will focus on the electronic contribution to the thermal transport. The charge carriers are described as massive chiral particles through an effective Dirac-like Hamiltonian. The Hybrid matrix method and the Landauer-Büttiker formalism are implemented to obtain the transmission, transport and thermoelectric properties. The temperature dependence of the Seebeck coefficient, the power factor, the figure of merit and the efficiency is analyzed for gapless single and double barriers. We find that the charge neutrality point and the system resonances shape the thermoelectric response. In the case of single barriers, the low-temperature thermoelectric response is dominated by the charge neutrality point, while the high-temperature response is determined by the Fano resonances. In the case of double barriers, Breit-Wigner resonances dominate the thermoelectric properties at low temperatures, while Fano and hybrid resonances become preponderant as the temperature rises. The values for the figure of merit are close to two for single barriers and above three for double barriers. The system resonances also allows us to optimize the output power and the efficiency at low and high temperatures. By computing the density of states, we also corroborate that the improvement of the thermoelectric properties is related to the accumulation of electron states. Our findings indicate that bilayer graphene barrier structures can be used to improve the response of thermoelectric devices.

85. Influence of ontogenetic development, temperature, and pCO(2) on otolith calcium carbonate polymorph composition in sturgeons.

Sci Rep

2021 Jul 6

Loeppky AR, Belding LD, Quijada-Rodriguez AR

86. Effect of earthworm Eisenia fetida epidermal mucus on the vitality and pathogenicity of Beauveria bassiana.

Sci Rep

2021 Jul 6

Zhou X, Liang W, Zhang Y

87. A unique volatile signature distinguishes malaria infection from other conditions that cause similar symptoms.

Sci Rep

2021 Jul 6

Pulido H, Stanczyk NM, De Moraes CM

88. Acute effect of high-definition and conventional tDCS on exercise performance and psychophysiological responses in endurance athletes: a randomized controlled trial.

Sci Rep

2021 Jul 6

da Silva Machado DG, Bikson M, Datta A

Transcranial direct current stimulation (tDCS) has been used aiming to boost exercise performance and inconsistent findings have been reported. One possible explanation is related to the limitations of the so-called "conventional" tDCS, which uses large rectangular electrodes, resulting in a diffuse electric field. A new tDCS technique called high-definition tDCS (HD-tDCS) has been recently developed. HD-tDCS uses small ring electrodes and produces improved focality and greater magnitude of its aftereffects. This study tested whether HD-tDCS would improve exercise performance to a greater extent than conventional tDCS. Twelve endurance athletes (29.4 ± 7.3 years; 60.15 ± 5.09 ml kg-1 min-1) were enrolled in this single-center, randomized, crossover, and sham-controlled trial. To test reliability, participants performed two time to exhaustion (TTE) tests (control conditions) on a cycle simulator with 80% of peak power until volitional exhaustion. Next, they randomly received HD-tDCS (2.4 mA), conventional (2.0 mA), or active sham tDCS (2.0 mA) over the motor cortex for 20-min before performing the TTE test. TTE, heart rate (HR), associative thoughts, peripheral (lower limbs), and whole-body ratings of perceived exertion (RPE) were recorded every minute. Outcome measures were reliable. There was no difference in TTE between HD-tDCS (853.1 ± 288.6 s), simulated conventional (827.8 ± 278.7 s), sham (794.3 ± 271.2 s), or control conditions (TTE1 = 751.1 ± 261.6 s or TTE2 = 770.8 ± 250.6 s) [F(1.95; 21.4) = 1.537; P = 0.24; η2p = 0.123]. There was no effect on peripheral or whole-body RPE and associative thoughts (P > 0.05). No serious adverse effect was reported. A single session of neither HD-tDCS nor conventional tDCS changed exercise performance and psychophysiological responses in athletes, suggesting that a ceiling effect may exist.

89. Tropical cyclones cumulatively control regional carbon fluxes in Everglades mangrove wetlands (Florida, USA).

Sci Rep

2021 Jul 6

Zhao X, Rivera-Monroy VH, Farfán LM

90. Colonization of Warsaw by the red fox Vulpes vulpes in the years 1976-2019.

Sci Rep

2021 Jul 6

Jackowiak M, Gryz J, Jasińska K

91. U-Pb ages of detrital zircons in Cretaceous-Paleogene/Neogene kaolins within Eastern Dahomey and Niger Delta Basins (Nigeria) as provenance indicators.

Sci Rep

2021 Jul 5

Oyebanjo O, Ekosse GI, Odiyo J.

92. Kinetics modeling, thermodynamics and thermal performance assessments of pyrolytic decomposition of Moringa oleifera husk and Delonix regia pod.

Sci Rep

2021 Jul 5

Balogun AO, Adeleke AA, Ikubanni PP

93. High expression of miR-17-5p in tumor epithelium is a predictor for poor prognosis for prostate cancer patients.

Sci Rep

2021 Jul 5

Stoen MJ, Andersen S, Rakaee M

94. Targeting mitochondrial reactive oxygen species-mediated oxidative stress attenuates nicotine-induced cardiac remodeling and dysfunction.

Sci Rep

2021 Jul 5

Ramalingam A, Budin SB, Mohd Fauzi N

95. Development and testing of a game-based digital intervention for working memory training in autism spectrum disorder.

Sci Rep

2021 Jul 5

Wagle S, Ghosh A, Karthic P

96. Experimental infection of Asian house geckos with Enterococcus lacertideformus demonstrates multiple disease transmission routes and the in-vivo efficacy of antibiotics.

Sci Rep

2021 Jul 5

Agius JE, Rose K, Emery JP

The disease caused by Enterococcus lacertideformus is multisystemic and ultimately fatal. Since its emergence, the bacterium has significantly impacted the captive breeding programs of the extinct in the wild Christmas Island Lister's gecko (Lepidodactylus listeri) and blue-tailed skink (Cryptoblepharus egeriae). The bacterium's pathogenicity, inability to grow in-vitro, and occurrence beyond the confines of Christmas Island necessitated the development of an experimental infection and treatment model. Asian house geckos (Hemidactylus frenatus) were challenged with a single dose of E. lacertideformus inoculum either by mouth, application to mucosal abrasion or skin laceration, subcutaneous injection, coelomic injection, or via co-housing with an infected gecko. Five healthy geckos acted as controls. Each transmission route resulted in disease in at least 40% (n = 2) geckos, expanding to 100% (n = 5) when E. lacertideformus was applied to skin laceration and mucosal abrasion groups. Incubation periods post-infection ranged between 54 and 102 days. To determine the efficacy of antibiotic treatment, infected geckos were divided into six groups (enrofloxacin 10 mg/kg, per os (PO), every 24 h (q24), amoxicillin-clavulanic acid 10 mg/kg, PO, q24, enrofloxacin 10 mg/kg combined with amoxicillin-clavulanic acid 10 mg/kg, PO, q24, rifampicin 15 mg/kg, PO, q24, clarithromycin 15 mg/kg, PO, q24, and untreated controls) for 21 days. Response to treatment was assessed by the change in lesion size, bacterial dissemination, and histological evidence of a host immune response. Irrespective of the antibiotic given, histology revealed that geckos inoculated by skin laceration were observed to have more extensive disease spread throughout the animal's body compared to other inoculation routes. The reduction in the average surface area of gross lesions was 83.6% for geckos treated with enrofloxacin, followed by the combination therapy amoxicillin-clavulanic acid and enrofloxacin (62.4%), amoxicillin-clavulanic acid (58.2%), rifampicin (45.5%), and clarithromycin (26.5%). Lesions in geckos untreated with antibiotics increased in size between 100 and 300%. In summary, enrofloxacin and amoxicillin-clavulanic acid show promising properties for the treatment of E. lacertideformus infection in geckos. The Asian house gecko E. lacertideformus infection model therefore provides foundational findings for the development of effective therapeutic treatment protocols aimed at conserving the health of infected and at-risk reptiles.

97. An immunoinformatics approach to design a multi-epitope vaccine against Mycobacterium tuberculosis exploiting secreted exosome proteins.

Sci Rep

2021 Jul 5

Sharma R(#), Rajput VS(#), Jamal S

98. Quantum dot assisted luminescent hexarhenium cluster dye for a transparent luminescent solar concentrator.

Sci Rep

2021 Jul 5

Choi J, Kim K, Kim SJ.

99. Severe Little Ice Age drought in the midcontinental United States during the Mississippian abandonment of Cahokia.

Sci Rep

2021 Jul 5

Pompeani DP, Bird BW, Wilson JJ

100. Staphylococcus aureus enhances biofilm formation, aerotolerance, and survival of Campylobacter strains isolated from retail meats.

Sci Rep

2021 Jul 5

Karki AB, Ballard K, Harper C

101. Bone mineral density response prediction following osteoporosis treatment using machine learning to aid personalized therapy.

Sci Rep

2021 Jul 5

Tanphiriyakun T, Rojanasthien S, Khumrin P.

102. Accurate long-range forecasting of COVID-19 mortality in the USA.

Sci Rep

2021 Jul 5

Ramazi P, Haratian A, Meghdadi M

103. Discovery of spatial pattern of prickles on stem of Rosa hybrida 'Red Queen' and mathematical model of the pattern.

Sci Rep

2021 Jul 5

Amikura K, Ito H, Kitazawa MS.

104. Tailoring the effect of antithrombin-targeting therapy in haemophilia A using in silico thrombin generation.

Sci Rep

2021 Jul 30

de Laat-Kremers RMW, Ninivaggi M, van Moort I

105. Earthworms drastically change fungal and bacterial communities during vermicomposting of sewage sludge.

Sci Rep

2021 Jul 30

Domínguez J, Aira M, Crandall KA

106. High-resolution model of Arabidopsis Photosystem II reveals the structural consequences of digitonin-extraction.

Sci Rep

2021 Jul 30

Graça AT, Hall M, Persson K

107. Integrative analysis of the choroid by quantifying Haller vessel and choriocapillaris parameters in different drusen subtypes.

Sci Rep

2021 Jul 30

Lee H, Kim S, Kim MA

108. Dynamic changes in mitochondrial 3D structure during folliculogenesis and luteal formation in the goat large luteal cell lineage.

Sci Rep

2021 Jul 30

Jiang YF, Yu PH, Budi YP

109. Boron rich nanotube drug carrier system is suited for boron neutron capture therapy.

Sci Rep

2021 Jul 30

Heide F(#), McDougall M(#), Harder-Viddal C

110. Analysis of planes within reduced micromorphic model.

Sci Rep

2021 Jul 30

Dhaba ARE, Mousavi SM.

111. Over 30% efficiency bifacial 4-terminal perovskite-heterojunction silicon tandem solar cells with spectral albedo.

Sci Rep

2021 Jul 30

Kim S, Trinh TT, Park J

112. Development of a CNS-permeable reactivator for nerve agent exposure: an iterative, multi-disciplinary approach.

Sci Rep

2021 Jul 30

Bennion BJ, Malfatti MA, Be NA

113. Multiple climate change-driven tipping points for coastal systems.

Sci Rep

2021 Jul 30

Barnard PL, Dugan JE, Page HM

114. Hydralazine augmented ultrasound hyperthermia for the treatment of hepatocellular carcinoma.

Sci Rep

2021 Jul 30

Karmacharya MB(#), Sultan LR(#), Hunt SJ

115. Identification of non-classical hCA XII inhibitors using combination of computational approaches for drug design and discovery.

Sci Rep

2021 Jul 30

Al-Sanea MM(#), Chilingaryan G(#), Abelyan N(#)

116. GC-TOF/MS-based metabolomics analysis to investigate the changes driven by N-Acetylcysteine in the plant-pathogen Xanthomonas citri subsp. citri.

Sci Rep

2021 Jul 30

Picchi SC, de Souza E Silva M, Saldanha LL

117. The impacts of road traffic on urban air quality in Jinan based GWR and remote sensing.

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2021 Jul 30

Wang Q, Feng H, Feng H

118. Boosting people's ability to detect microtargeted advertising.

Sci Rep

2021 Jul 30

Lorenz-Spreen P(#), Geers M, Pachur T

119. Brain-dead and coma patients exhibit different serum metabolic profiles: preliminary investigation of a novel diagnostic approach in neurocritical care.

Sci Rep

2021 Jul 30

Dawiskiba T(#), Wojtowicz W(#), Qasem B

120. Maternal blood count parameters of chronic inflammation by gestational age and their associations with risk of preterm delivery in the Japan Environment and Children's Study.

Sci Rep

2021 Jul 30

Morisaki N, Piedvache A, Nagata C

121. Configuration of flowsheet and reagent dosage for gilsonite flotation towards the ultra-low-ash concentrate.

Sci Rep

2021 Jul 29

Bahrami A, Kazemi F, Mirmohammadi M

Gilsonite has a wide variety of applications in the industry, including the manufacture of electrodes, paints and resins, as well as the production of asphalt and roof-waterproofing material. Gilsonite ash is a determining parameter for its application in some industries (e.g., gilsonite with ash content < 5% used as an additive in drilling fluids, resins). Due to the shortage of high grade (low ash) gilsonite reserves, the aim of this study is to develop a processing flowsheet for the production of ultra-low-ash gilsonite (< 5%), based on process mineralogy studies and processing tests. For this purpose, mineralogical studies and flotation tests have been performed on a sample of gilsonite with an average ash content of 15%. According to mineralogical studies, carbonates and clay minerals are the main associated impurities (more than 90 vol.%). Furthermore, sulfur was observed in two forms of mineral (pyrite and marcasite) and organic in the structure of gilsonite. Most of these impurities are interlocked with gilsonite in size fractions smaller than 105 µm. The size fraction of + 105 - 420 µm has a higher pure gilsonite (approximately 90%) than other size fractions. By specifying the gangue minerals with gilsonite and the manner and extent of their interlocking with gilsonite, + 75 - 420 µm size fraction selected to perform flotation tests. Flotation tests were performed using different reagents including collector (Gas oil, Kerosene and Pine oil), frother (MIBC) and depressant (sodium silicate, tannic acid, sulfuric acid and sodium cyanide) in different dosages. Based on the results, the use of kerosene collector, MIBC frother and a mixture of sodium silicate, tannic acid, sulfuric acid and sodium cyanide depressant had the most favorable results in gilsonite flotation in the rougher stage. Cleaner and recleaner flotation stages for the rougher flotation concentrate resulted in a product with an ash content of 4.89%. Due to the interlocking of gilsonite with impurities in size fractions - 105 µm, it is better to re-grinding the concentrate of the rougher stage beforehand flotation in the cleaner and recleaner stages. Finally, based on the results of mineralogical studies and processing tests, a processing flowsheet including crushing and initial granulation of gilsonite, flotation in rougher, cleaner and recleaner stages has been proposed to produce gilsonite concentrate with < 5% ash content.

122. Environmental determinants of the occurrence and activity of Ixodes ricinus ticks and the prevalence of tick-borne diseases in eastern Poland.

Sci Rep

2021 Jul 29

Zając Z, Kulisz J, Bartosik K

123. Response of compacted bentonite to hyperalkalinity and thermal history.

Sci Rep

2021 Jul 29

Kale RC, Kapil B, Ravi K.

The use of compacted bentonite around the high-level nuclear waste canister (HLW) inside the deep geological repository (DGR) ensures the prevention of entry of active radionuclides in the atmosphere due to its noteworthy large swelling ability. In the eventual repository, the waste canister has a high (100 °C-200 °C) temperature initially, and it reduces over a vast period, which induces a thermal history over the compacted bentonite layer. The cement/concrete layer is constructed as a bulkhead or in the vaults or to support the access of galleries between a buffer and the host rock, and it degrades over the period. The hyperalkaline fluid is created when it percolates through the cement/concrete layer and comes in contact with the compacted bentonite. The contact of hyperalkaline fluid to compacted bentonite induced with thermal history can hamper the swell pressure characteristic of the bentonite. Therefore to determine the combined effect of hyperalkalinity to the thermal history induced compacted bentonite, swell pressure testing has been conducted on two compacted Barmer bentonites (B1 and B2) specimens with an initial dry density of 1.5 Mg/m3, 1.75 Mg/m3, and 2.0 Mg/m3 and saturated with distilled water as well as with hyperalkaline cement water (W/C = 1 und pH = 12.5) and heated to 110 °C and 200 °C. When the specimens were saturated with hyperalkaline cement water, the swell pressure exerted by both bentonites was noticeably reduced compared to specimens saturated with distilled water. Nevertheless, the time taken to full saturation was longer than distilled water for samples saturated with hyperalkaline cement water. Also, the decrease in swell pressure was observed in the samples subjected to thermal history than samples, which were tested without inducing thermal history in both the cases of hyperalkaline cement water and distilled water. The microstructural observations through XRD, FESEM and EDX revealed the clogging of pores due to the presence of non-swelling minerals.

124. Machine learning to predict distal caries in mandibular second molars associated with impacted third molars.

Sci Rep

2021 Jul 29

Hur SH(#), Lee EY(#), Kim MK(#)

125. Non-communicable diseases deaths attributable to high body mass index in Chile.

Sci Rep

2021 Jul 29

Riquelme R, Rezende LFM, Guzmán-Habinger J

126. Effects of different returning method combined with decomposer on decomposition of organic components of straw and soil fertility.

Sci Rep

2021 Jul 29

Wang X, Wang X, Geng P

In view of the problems of low straw decomposition rates and reduced soil fertility in southern Liaoning, China, we investigated the effects of no-tillage mode (NT), deep loosening + deep rotary tillage mode (PT), rotary tillage mode (RT) and the addition of decomposing agent (the next is called a decomposer) (NT + S, PT + S, RT + S) on the decomposition proportion of straw, respectively, by using the nylon net bag method in combination with 365-day field plot experiments. The decomposition rules of cellulose, hemicellulose and lignin as well as the dynamics of soil organic carbon (SOC), soil microbial biomass carbon (MBC) and soil dissolved organic carbon (DOC) in straw returned to the field for 15, 35, 55, 75, 95, 145 and 365 days were analyzed. The results showed that in the short term, the decomposition of straw was better in both the rotray tillage and deep loosening + deep rotary modes than in the no-tillage mode, and the addition of decomposer significantly promoted the decomposition of straw and the release of carbon from straw, among them, the RT + S treatment had the highest straw decomposition proportion and carbon release proportion in all sampling periods. After a one year experimental cycle, the RT + S treatment showed the highest proportion of cellulose, hemicellulose and lignin decomposition with 35.49%, 84.23% and 85.50%, respectively, and soil SOC, MBC and DOC contents were also higher than the other treatments with an increase of 2.30 g kg-1, 14.22 mg kg-1 and 25.10 mg kg-1, respectively, compared to the pre-experimental soil. Our results show that in the short term, to accelerate the decomposition rate of returned straw and increase the content of various forms of carbon in soil, rotary tillage can be used to return the straw to the field, while also spraying straw decomposer on its surface. This experiment used a new straw decomposer rich in a variety of microorganisms, combined with the comparison of a variety of straw return modes, and in-depth study of straw decomposition effects of cellulose, hemicellulose and lignin. Thus, a scheme that can effectively improve the decomposition rate of straw and the content of various forms of organic carbon in soil within a short period of time was explored to provide theoretical support for the southern Liaoning.

127. Robust chitinolytic activity of crab-eating monkey (Macaca fascicularis) acidic chitinase under a broad pH and temperature range.

Sci Rep

2021 Jul 29

Uehara M, Tabata E, Okuda M

128. Myeloid-IL4Rα is an indispensable link in IL-33-ILCs-IL-13-IL4Rα axis of eosinophil recruitment in murine lungs.

Sci Rep

2021 Jul 29

Patial S, Lewis BW, Vo T

129. Study on landslide susceptibility mapping based on rock-soil characteristic factors.

Sci Rep

2021 Jul 29

Yu X, Zhang K, Song Y

130. Feasibility of generating 90 Hz vibrations in remote implanted magnets.

Sci Rep

2021 Jul 29

Montero J, Clemente F, Cipriani C.

131. CRISPR/Cas9-based genetic screen of SCNT-reprogramming resistant genes identifies critical genes for male germ cell development in mice.

Sci Rep

2021 Jul 29

Akter MS, Hada M, Shikata D

132. Association of incremental pulse wave velocity with cardiometabolic risk factors.

Sci Rep

2021 Jul 29

Nabeel PM, Chandran DS, Kaur P

133. Muscle synergy differences between voluntary and reactive backward stepping.

Sci Rep

2021 Jul 29

Wang S, Varas-Diaz G, Bhatt T.

134. Predictors of chronic opioid therapy in Medicaid beneficiaries with HIV who initiated antiretroviral therapy.

Sci Rep

2021 Jul 29

Oh G, Brouwer ES, Abner EL

135. Prognostic value of CD34 expression status in patients with myxofibrosarcomas and undifferentiated pleomorphic sarcomas.

Sci Rep

2021 Jul 29

Sugiura Y, Machinami R, Matsumoto S

136. A piggyBac-based platform for genome editing and clonal rhesus macaque iPSC line derivation.

Sci Rep

2021 Jul 29

Rodriguez-Polo I, Mißbach S, Petkov S

137. Adaptive ecological niche migration does not negate extinction susceptibility.

Sci Rep

2021 Jul 29

Woodhouse A, Jackson SL, Jamieson RA

138. Enhanced sunlight driven photocatalytic activity of In(2)S(3) nanosheets functionalized MoS(2) nanoflowers heterostructures.

Sci Rep

2021 Jul 28

Singh J, Soni RK.

139. Characterization of humic acids from original coal and its oxidization production.

Sci Rep

2021 Jul 28

Yan S, Zhang N, Li J

140. A phenotypic high-content, high-throughput screen identifies inhibitors of NLRP3 inflammasome activation.

Sci Rep

2021 Jul 28

Nizami S(#), Millar V(#), Arunasalam K

141. Eco-friendly stability-indicating RP-HPTLC method for sildenafil analysis, characterization and biological evaluation of its oxidized stress degradation product.

Sci Rep

2021 Jul 28

Abdel-Kader MS, Alam P, Soliman GA

142. Periodic limb movements in patients with obstructive sleep apnea syndrome.

Sci Rep

2021 Jul 28

Zhou X, Zhou B, Li Z

143. Effect of cryoprotectant concentration on bovine oocyte permeability and comparison of two membrane permeability modelling approaches.

Sci Rep

2021 Jul 28

García-Martínez T, Mogas T, Mullen SF

144. The influence of subcolony-scale nesting habitat on the reproductive success of Adélie penguins.

Sci Rep

2021 Jul 28

Schmidt AE, Ballard G, Lescroël A

Group-size variation is common in colonially breeding species, including seabirds, whose breeding colonies can vary in size by several orders of magnitude. Seabirds are some of the most threatened marine taxa and understanding the drivers of colony size variation is more important than ever. Reproductive success is an important demographic parameter that can impact colony size, and it varies in association with a number of factors, including nesting habitat quality. Within colonies, seabirds often aggregate into distinct groups or subcolonies that may vary in quality. We used data from two colonies of Adélie penguins 73 km apart on Ross Island, Antarctica, one large and one small to investigate (1) How subcolony habitat characteristics influence reproductive success and (2) How these relationships differ at a small (Cape Royds) and large (Cape Crozier) colony with different terrain characteristics. Subcolonies were characterized using terrain attributes (elevation, slope aspect, slope steepness, wind shelter, flow accumulation), as well group characteristics (area/size, perimeter-to-area ratio, and proximity to nest predators). Reproductive success was higher and less variable at the larger colony while subcolony characteristics explained more of the variance in reproductive success at the small colony. The most important variable influencing subcolony quality at both colonies was perimeter-to-area ratio, likely reflecting the importance of nest predation by south polar skuas along subcolony edges. The small colony contained a higher proportion of edge nests thus higher potential impact from skua nest predation. Stochastic environmental events may facilitate smaller colonies becoming "trapped" by nest predation: a rapid decline in the number of breeding individuals may increase the proportion of edge nests, leading to higher relative nest predation and hindering population recovery. Several terrain covariates were retained in the final models but which variables, the shapes of the relationships, and importance varied between colonies.

145. Expression of HO1 and PER2 can predict the incidence of delirium in trauma patients with concomitant brain injury.

Sci Rep

2021 Jul 28

Steimer M, Kaiser S, Ulbrich F

146. The role of IL-18 in addition to Th17 cytokines in rheumatoid arthritis development and treatment in women.

Sci Rep

2021 Jul 28

Vasilev G, Manolova I, Ivanova M

147. DNA methylation of Vesicular Glutamate Transporters in the mesocorticolimbic brain following early-life stress and adult ethanol exposure-an explorative study.

Sci Rep

2021 Jul 28

Vrettou M, Yan L, Nilsson KW

148. Increased sugar-sweetened beverage use tendency in pregnancy positively associates with peripartum Edinburgh postpartum depression scores.

Sci Rep

2021 Jul 28

Ker CR, Wu CH, Lee CH

The association among sugar sweetened beverages (SSB) consumption, addiction and depression in adults, children and adolescents is widely reported. Dieting patterns during pregnancy is complicated by maternal fetal concerns. Specifically, restrained use of SSB might be potentially a source of perinatal distress. The current study modified diagnostic criteria for Substance Use Disorder (SUD) in Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5), into SSB-specific questions to assess SSB use tendency. Edinburgh Postpartum Depression Scores (EPDS) is used to assess maternal distress during pregnancy. One hundred and ninety-six consecutive pregnant women receiving antenatal care at Kaohsiung Medical University Hospital were invited to participate in this study. In the first trimester, 46.6% of women had none or 1 DSM-5 symptom, 27.0% had 2-3 symptoms, while 26.4% had ≥ 4 symptoms. The mean numbers of DSM-5 symptoms in each trimester were found to be 2.5 ± 2.25, 2.6 ± 2.45, 2.4 ± 2.43 for the first, second and third trimester, respectively, p = 0.750. While EPDS score showed no difference among DSM-5 symptoms 0-1, 2-3 and ≥ 4 groups in the first trimester (8.1 ± 4.59, 8.4 ± 5.00, 8.8 ± 4.82, p = 0.343), women with ≥ 4 DSM-symptoms was found significantly higher EPDS scores than those with < 4 DSM-symptoms in the second (7.2 ± 4.81, 7.7 ± 4.98, 8.8 ± 4.33, p = 0.030) and third trimester (6.8 ± 5.00, 7.2 ± 4.63, 8.7 ± 5.24, p = 0.019). The relationship remained significant after adjusting for covariates including actual SSB amount consumed (adjusted β = 0.25 with 95% confident interval (CI) 0.04-0.45 and 0.21 with 95% CI 0.04-0.38 for the second and third trimesters, respectively). Overall, the study is the first to characterize the positive relationship between SSB use tendency and antenatal distress in pregnancy, independent of actual SSB amount consumed. The observational nature of the study design precludes inferences of its underlying socio-psychomotor mechanisms, although restrained SSB use in pregnancy is suspected to contribute. The novel employment of modified SSB-specific DSM-5 scores and EPDS in this setting is feasible and further validation is promising. With better understanding and awareness, pregnant women with increased SSB use tendency should be properly counseled with special attention to their mental state.

149. Effective cesium removal from Cs-containing water using chemically activated opaline mudstone mainly composed of opal-cristobalite/tridymite (opal-CT).

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2021 Jul 28

Kwon S, Kim Y, Roh Y.

150. Vacancy tuned thermoelectric properties and high spin filtering performance in graphene/silicene heterostructures.

Sci Rep

2021 Jul 28

Gholami Z, Khoeini F.

151. Variation features of unfrozen water content of water-saturated coal under low freezing temperature.

Sci Rep

2021 Jul 28

Li B, Huang L, Lv X

152. Detecting suicidal risk using MMPI-2 based on machine learning algorithm.

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2021 Jul 28

Kim S, Lee HK, Lee K.

153. Specificity of UV-C LED disinfection efficacy for three N95 respirators.

Sci Rep

2021 Jul 28

Ontiveros CC, Shoults DC, MacIsaac S

154. Demonstration of central conduction time and neuroplastic changes after cervical lordosis rehabilitation in asymptomatic subjects: a randomized, placebo-controlled trial.

Sci Rep

2021 Jul 28

Moustafa IM, Diab AA, Hegazy F

155. Bifunctional catalytic effect of Mo(2)C/oxide interface on multi-layer graphene growth.

Sci Rep

2021 Jul 28

Kizir S, van den Beld WTE, Schurink B

156. Cardiorespiratory fitness assessment using risk-stratified exercise testing and dose-response relationships with disease outcomes.

Sci Rep

2021 Jul 28

Gonzales TI, Westgate K, Strain T

157. A global assessment of surveillance methods for dominant malaria vectors.

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2021 Jul 28

van de Straat B, Russell TL, Staunton KM

158. Insula reactivity mediates subjective isolation stress in alexithymia.

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2021 Jul 28

Morr M(#), Lieberz J(#), Dobbelstein M

159. Association between comorbid asthma and prognosis of critically ill patients with severe sepsis: a cohort study.

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2021 Jul 28

Huang J(#), Zhang J(#), Wang F

Basic research suggests some contributing mechanisms underlying asthma might at the same time benefit patients with asthma against sepsis, while the potential protective effect of comorbid asthma on prognosis of sepsis has not been well studied in clinical research. The study aimed to assess the association between comorbid asthma and prognosis in a cohort of patients admitted to intensive care unit (ICU) with severe sepsis. Patients with severe sepsis admitted to ICUs were included from the MIMIC-III Critical Care Database, and categorized as patients without asthma, patients with stable asthma, and patients with acute exacerbation asthma. The primary study outcome was 28-day mortality since ICU admission. Difference in survival distributions among groups were evaluated by Kaplan-Meier estimator. Multivariable Cox regression was employed to examine the association between comorbid asthma and prognosis. A total of 2469 patients with severe sepsis were included, of which 2327 (94.25%) were without asthma, 125 (5.06%) with stable asthma, and 17 (0.69%) with acute exacerbation asthma. Compared with patients without asthma, patients with asthma (either stable or not) had a slightly younger age (66.73 ± 16.32 versus 64.77 ± 14.81 years), a lower proportion of male sex (56.81% versus 40.14%), and a lower median SAPS II score (46 versus 43). Patients with acute exacerbation asthma saw the highest 28-day mortality rate (35.29%), but patients with stable asthma had the lowest 28-day mortality rate (21.60%) when compared to that (34.42%) in patients without asthma. Consistent results were observed in Kaplan-Meier curves with a p-value for log-rank test of 0.016. After adjusting for potential confounding, compared to being without asthma, being with stable asthma was associated with a reduced risk of 28-day mortality (hazard ratio (HR) 0.65, 95% confidence interval (CI) 0.44-0.97, p = 0.0335), but being with acute exacerbation asthma was toward an increased risk of 28-day mortality (HR 1.82, 95% 0.80-4.10, p = 0.1513). E-value analysis suggested robustness to unmeasured confounding. These findings suggest comorbid stable asthma is associated with a better prognosis in critically ill patients with severe sepsis, while acute exacerbation asthma is associated with worse prognosis.

160. Multiple evolutionary lineages for the main vector of Leishmania guyanensis, Lutzomyia umbratilis (Diptera: Psychodidae), in the Brazilian Amazon.

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2021 Jul 28

Scarpassa VM, Cunha-Machado AS, Alencar RB.

161. Feasibility and effectiveness of endoscopic irreversible electroporation for the upper gastrointestinal tract: an experimental animal study.

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2021 Jul 28

Jeon HJ(#), Choi HS(#), Keum B

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2021 Jul 28

Horn SS, Avrahami J, Kareev Y

163. An octa-band planar monopole antenna for portable communication devices.

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2021 Jul 27

Azim R, Alam T, Mia MS

164. Environment-induced overheating phenomena in Au-nanowire based Josephson junctions.

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2021 Jul 27

Skryabina OV(#), Bakurskiy SV(#), Shishkin AG

165. Impacts of treatments on recurrence and 28-year survival of ischemic stroke patients.

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2021 Jul 27

Wang TA, Wu TH, Pan SL

166. Association between statin use and Alzheimer's disease with dose response relationship.

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2021 Jul 27

Jeong SM, Shin DW, Yoo TG

167. Knockdown screening of chromatin binding and regulatory proteins in zebrafish identified Suz12b as a regulator of tfpia and an antithrombotic drug target.

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2021 Jul 27

Raman R, Fallatah W, Al Qaryoute A

168. The association between carotid blood flow and resting-state brain activity in patients with cerebrovascular diseases.

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2021 Jul 27

Matsumoto T, Hoshi H, Hirata Y

169. Structural colors of pearls.

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2021 Jul 27

Ozaki R, Kikumoto K, Takagaki M

170. The bifidobacterial distribution in the microbiome of captive primates reflects parvorder and feed specialization of the host.

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2021 Jul 27

Modrackova N, Stovicek A, Burtscher J

171. Shotgun lipidomics of liver and brain tissue of Alzheimer's disease model mice treated with acitretin.

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2021 Jul 27

Lauer AA(#), Janitschke D(#), Dos Santos Guilherme M(#)

172. Mechanisms that allow vaccination against an oncolytic vesicular stomatitis virus-encoded transgene to enhance safety without abrogating oncolysis.

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2021 Jul 27

AuYeung AWK, Mould RC, Stegelmeier AA(#)

173. Lower peripheral blood Toll-like receptor 3 expression is associated with an unfavorable outcome in severe COVID-19 patients.

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2021 Jul 27

Menezes MCS, Veiga ADM, Martins de Lima T

174. A data-driven approach to modeling cancer cell mechanics during microcirculatory transport.

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2021 Jul 27

Balogh P, Gounley J, Roychowdhury S

In order to understand the effect of cellular level features on the transport of circulating cancer cells in the microcirculation, there has been an increasing reliance on high-resolution in silico models. Accurate simulation of cancer cells flowing with blood cells requires resolving cellular-scale interactions in 3D, which is a significant computational undertaking warranting a cancer cell model that is both computationally efficient yet sufficiently complex to capture relevant behavior. Given that the characteristics of metastatic spread are known to depend on cancer type, it is crucial to account for mechanistic behavior representative of a specific cancer's cells. To address this gap, in the present work we develop and validate a means by which an efficient and popular membrane model-based approach can be used to simulate deformable cancer cells and reproduce experimental data from specific cell lines. Here, cells are modeled using the immersed boundary method (IBM) within a lattice Boltzmann method (LBM) fluid solver, and the finite element method (FEM) is used to model cell membrane resistance to deformation. Through detailed comparisons with experiments, we (i) validate this model to represent cancer cells undergoing large deformation, (ii) outline a systematic approach to parameterize different cell lines to optimally fit experimental data over a range of deformations, and (iii) provide new insight into nucleated vs. non-nucleated cell models and their ability to match experiments. While many works have used the membrane-model based method employed here to model generic cancer cells, no quantitative comparisons with experiments exist in the literature for specific cell lines undergoing large deformation. Here, we describe a phenomenological, data-driven approach that can not only yield good agreement for large deformations, but explicitly detail how it can be used to represent different cancer cell lines. This model is readily incorporated into cell-resolved hemodynamic transport simulations, and thus offers significant potential to complement experiments towards providing new insights into various aspects of cancer progression.

175. Differential prioritization of intramaze cue and boundary information during spatial navigation across the human lifespan.

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2021 Jul 27

Glöckner F, Schuck NW, Li SC.

176. Illegal fishing with electrofishing devices in the Po river basin, Emilia Romagna, Italy.

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2021 Jul 27

Mazzariol S, Corazzola G, Rubini S

177. Monocyte-dependent co-stimulation of cytokine induction in human γδ T cells by TLR8 RNA ligands.

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2021 Jul 27

Serrano R(#), Coch C, Peters C

178. Fast and scalable likelihood maximization for Exponential Random Graph Models with local constraints.

Sci Rep

2021 Jul 27

Vallarano N, Bruno M, Marchese E

179. Comparative assessment of amino acids composition in two types of marine fish silage.

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2021 Jul 27

Gauthankar M, Khandeparker R, Shivaramu MS

180. Analysis of long intergenic non-coding RNAs transcriptomic profiling in skeletal muscle growth during porcine embryonic development.

Sci Rep

2021 Jul 27

Zhao W, Li Z, Liu Q

Skeletal muscle growth plays a critical role during porcine muscle development stages. Genome-wide transcriptome analysis reveals that long intergenic non-coding RNAs (lincRNAs) are implicated as crucial regulator involving in epigenetic regulation. However, comprehensive analysis of lincRNAs in embryonic muscle development stages remain still elusive. Here, we investigated the transcriptome profiles of Duroc embryonic muscle tissues from days 33, 65, and 90 of gestation using RNA-seq, and 228 putative lincRNAs were identified. Moreover, these lincRNAs exhibit the characteristics of shorter transcripts length, longer exons, less exon numbers and lower expression level compared with protein-coding transcripts. Expression profile analysis showed that a total of 120 lincRNAs and 2638 mRNAs were differentially expressed. In addition, we also performed quantitative trait locus (QTL) mapping analysis for differentially expressed lincRNAs (DE lincRNAs), 113 of 120 DE lincRNAs were localized on 2200 QTLs, we observed many QTLs involved in growth and meat quality traits. Furthermore, we predicted potential target genes of DE lincRNAs in cis or trans regulation. Gene ontology and pathway analysis reveals that potential targets of DE lincRNAs mostly were enriched in the processes and pathways related to tissue development, MAPK signaling pathway, Wnt signaling pathway, TGF-beta signaling pathway and insulin signaling pathway, which involved in skeletal muscle physiological functions. Based on cluster analysis, co-expression network analysis of DE lincRNAs and their potential target genes indicated that DE lincRNAs highly regulated protein-coding genes associated with skeletal muscle development. In this study, many of the DE lincRNAs may play essential roles in pig muscle growth and muscle mass. Our study provides crucial information for further exploring the molecular mechanisms of lincRNAs during skeletal muscle development.

181. Evaluation of efficacy and safety of new high-density dyes for chromovitrectomy.

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2021 Jul 26

Piccirillo V, Sbordone S, Sorgente F

182. The role of salicylic acid and benzothiadiazole in decreasing phytoplasma titer of sugarcane white leaf disease.

Sci Rep

2021 Jul 26

Ratchaseema MTN, Kladsuwan L, Soulard L

183. Choroidal microvasculature dropout is spatially associated with optic nerve head microvasculature loss in open-angle glaucoma.

Sci Rep

2021 Jul 26

Song MK, Shin JW, Lee JY

184. Classification of glioblastoma versus primary central nervous system lymphoma using convolutional neural networks.

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2021 Jul 26

McAvoy M(#), Prieto PC(#), Kaczmarzyk JR

185. Benchmarking the Covid-19 pandemic across countries and states in the USA under heterogeneous testing.

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2021 Jul 26

Asahi K, Undurraga EA, Wagner R.

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2021 Jul 26

Hofhuis JGM, Schrijvers AJP, Schermer T

187. K(v)1.1 channels mediate network excitability and feed-forward inhibition in local amygdala circuits.

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2021 Jul 26

Thouta S, Zhang Y, Garcia E

188. Increasing medicinal and phytochemical compounds of coneflower (Echinacea purpurea L.) as affected by NO(3)(-)/NH(4)(+) ratio and perlite particle size in hydroponics.

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2021 Jul 26

Ahmadi F, Samadi A, Sepehr E

189. Development of mortality prediction model in the elderly hospitalized AKI patients.

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2021 Jul 26

Peng JC(#), Wu T(#), Wu X

190. FDG-PET predicts bone invasion and prognosis in patients with oral squamous cell carcinoma.

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2021 Jul 26

Lin NC, Su IH, Hsu JT

191. High thermal durability of Ru-based synthetic antiferromagnet by interfacial engineering with Re insertion.

Sci Rep

2021 Jul 26

Yang CL, Lai CH.

192. S494 O-glycosylation site on the SARS-CoV-2 RBD affects the virus affinity to ACE2 and its infectivity; a molecular dynamics study.

Sci Rep

2021 Jul 26

Rahnama S, Azimzadeh Irani M, Amininasab M

193. Mechanical activities of self-beating cardiomyocyte aggregates under mechanical compression.

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2021 Jul 26

Nakano K, Nanri N, Tsukamoto Y

194. Correlations between environmental salinity levels, blood biochemistry parameters, and steroid hormones in wild juvenile American alligators (Alligator mississippiensis).

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2021 Jul 26

Faulkner PC, Elsey RM, Hala D

195. Cat-CrNP as new material with catalytic properties for 2-chloro-2-propen-1-ol and ethylene oligomerizations.

Sci Rep

2021 Jul 26

Malinowski J, Jacewicz D, Sikorski A

196. A large-scale multi-institutional study evaluating prognostic aspects of positive ascites cytology and effects of therapeutic interventions in epithelial ovarian cancer.

Sci Rep

2021 Jul 26

Yoshihara M, Emoto R, Kitami K

197. AC conductivity and correlation effects in nano-granular Pt/C.

Sci Rep

2021 Jul 26

Hanefeld M, Gruszka P, Huth M.

198. Induction of cryptic pre-mRNA splice-switching by antisense oligonucleotides.

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2021 Jul 23

Ham KA(#), Keegan NP(#), McIntosh CS

199. Oxidative stress parameters as biomarkers of bladder cancer development and progression.

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2021 Jul 23

Wigner P, Szymańska B, Bijak M

200. Signal envelope and speech intelligibility differentially impact auditory motion perception.

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2021 Jul 23

Warnecke M, Litovsky RY.

201. Effects of in vivo repositioning of slim modiolar electrodes on electrical thresholds and speech perception.

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2021 Jul 23

Lee SY, Kim YS, Jo HD

202. Local intestinal microbiota response and systemic effects of feeding black soldier fly larvae to replace soybean meal in growing pigs.

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2021 Jul 23

Kar SK, Schokker D, Harms AC

203. Alcohol control policies add to secular trends in all-cause mortality rates in young adults.

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2021 Jul 23

Tran A, Manthey J, Lange S

204. Natural processes dominate the pollution levels during COVID-19 lockdown over India.

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2021 Jul 23

Madineni VR, Dasari HP, Karumuri R

205. On the mechanism of droplet rolling and spinning in inclined hydrophobic plates in wedge with different wetting states.

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2021 Jul 23

Yilbas BS, Yakubu M, Abubakar AA

206. BACE inhibitor treatment of mice induces hyperactivity in a Seizure-related gene 6 family dependent manner without altering learning and memory.

Sci Rep

2021 Jul 23

Nash A, Gijsen HJM, Hrupka BJ

BACE inhibitors, which decrease BACE1 (β-secretase 1) cleavage of the amyloid precursor protein, are a potential treatment for Alzheimer's disease. Clinical trials using BACE inhibitors have reported a lack of positive effect on patient symptoms and, in some cases, have led to increased adverse events, cognitive worsening and hippocampal atrophy. A potential drawback of this strategy is the effect of BACE inhibition on other BACE1 substrates such as Seizure-related gene 6 (Sez6) family proteins which are known to have a role in neuronal function. Mice were treated with an in-diet BACE inhibitor for 4-8 weeks to achieve a clinically-relevant level of amyloid-β40 reduction in the brain. Mice underwent behavioural testing and postmortem analysis of dendritic spine number and morphology with Golgi-Cox staining. Sez6 family triple knockout mice were tested alongside wild-type mice to identify whether any effects of the treatment were due to altered cleavage of Sez6 family proteins. Wild-type mice treated with BACE inhibitor displayed hyperactivity on the elevated open field, as indicated by greater distance travelled, but this effect was not observed in treated Sez6 triple knockout mice. BACE inhibitor treatment did not lead to significant changes in spatial or fear learning, reference memory, cognitive flexibility or anxiety in mice as assessed by the Morris water maze, context fear conditioning, or light-dark box tests. Chronic BACE inhibitor treatment reduced the density of mushroom-type spines in the somatosensory cortex, regardless of genotype, but did not affect steady-state dendritic spine density or morphology in the CA1 region of the hippocampus. Chronic BACE inhibition for 1-2 months in mice led to increased locomotor output but did not alter memory or cognitive flexibility. While the mechanism underlying the treatment-induced hyperactivity is unknown, the absence of this response in Sez6 triple knockout mice indicates that blocking ectodomain shedding of Sez6 family proteins is a contributing factor. In contrast, the decrease in mature spine density in cortical neurons was not attributable to lack of shed Sez6 family protein ectodomains. Therefore, other BACE1 substrates are implicated in this effect and, potentially, in the cognitive decline in longer-term chronically treated patients.

207. [Formula: see text] statistical ensemble: systems with fluctuating energy, particle number, and volume.

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2021 Jul 23

Marzolino U.

208. Effects of high-intensity training on the quality of life of cancer patients and survivors: a systematic review with meta-analysis.

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2021 Jul 23

Lavín-Pérez AM, Collado-Mateo D, Mayo X

209. A network approach to the five-facet model of mindfulness.

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2021 Jul 23

Heeren A, Lannoy S, Coussement C

210. Cascading effects of moth outbreaks on subarctic soil food webs.

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2021 Jul 23

Calderón-Sanou I, Münkemüller T, Zinger L

211. Identification of pathological transcription in autosomal dominant polycystic kidney disease epithelia.

Sci Rep

2021 Jul 23

Friedrich S(#), Müller H(#), Riesterer C(#)

212. Comparison of the efficacy of supraglottic airway devices in low-risk adult patients: a network meta-analysis and systematic review.

Sci Rep

2021 Jul 23

Lai CJ(#), Yeh YC(#), Tu YK

213. Randomized clinical trial shows no substantial modulation of empathy-related neural activation by intranasal oxytocin in autism.

Sci Rep

2021 Jul 23

Mayer AV(#), Wermter AK(#), Stroth S

214. Deep Learning Method to Accelerate Discovery of Hybrid Polymer-Graphene Composites.

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2021 Jul 23

Shayeganfar F, Shahsavari R.

215. A quantum material spintronic resonator.

Sci Rep

2021 Jul 23

Xu JW, Chen Y, Vargas NM

216. Evaluating the impact of decontamination interventions performed in sequence for mass casualty chemical incidents.

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2021 Jul 22

Collins S, Williams N, Southworth F

217. Comparison of ocular surface assessment and adherence between preserved and preservative-free latanoprost in glaucoma: a parallel-grouped randomized trial.

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2021 Jul 22

Kim DW(#), Shin J(#), Lee CK

218. Transcriptome analysis of flowering regulation by sowing date in Japonica Rice (Oryza sativa L.).

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2021 Jul 22

Yin M(#), Ma H(#), Wang M

219. Prognostic impact of pre-transplant chromosomal aberrations in peripheral blood of patients undergoing unrelated donor hematopoietic cell transplant for acute myeloid leukemia.

Sci Rep

2021 Jul 22

Wang Y, Zhou W, McReynolds LJ

220. Identification of prognostic alternative splicing events in sarcoma.

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2021 Jul 22

Li H(#), Yang J(#), Yang G

221. Comparative analysis of the bronchoalveolar microbiome in Portuguese patients with different chronic lung disorders.

Sci Rep

2021 Jul 22

Seixas S, Kolbe AR, Gomes S

222. Dissecting the chromosome-level genome of the Asian Clam (Corbicula fluminea).

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2021 Jul 22

Zhang T(#), Yin J(#), Tang S

223. Optical investigations and photoactive solar energy applications of new synthesized Schiff base liquid crystal derivatives.

Sci Rep

2021 Jul 22

Alamro FS, Gomha SM, Shaban M

224. Bimanual coupling effect during a proprioceptive stimulation.

Sci Rep

2021 Jul 22

Biggio M(#), Bisio A(#), Garbarini F

225. The value of GATA6 immunohistochemistry and computer-assisted diagnosis to predict clinical outcome in advanced pancreatic cancer.

Sci Rep

2021 Jul 22

Duan K, Jang GH, Grant RC

226. Cerebrospinal fluid oligoclonal immunoglobulin gamma bands and long-term disability progression in multiple sclerosis: a retrospective cohort study.

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2021 Jul 22

Karrenbauer VD, Bedri SK, Hillert J

227. A novel framework for designing a multi-DoF prosthetic wrist control using machine learning.

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2021 Jul 22

Swami CP, Lenhard N, Kang J.

228. Functional network topology of the right insula affects emotion dysregulation in hyperactive-impulsive attention-deficit/hyperactivity disorder.

Sci Rep

2021 Jul 22

Viering T, Hoekstra PJ, Philipsen A

229. Prevalence of low birth weight and macrosomia estimates based on heaping adjustment method in China.

Sci Rep

2021 Jul 22

Shen L, Wang J, Duan Y

230. Quasi-1D XY antiferromagnet Sr(2)Ni(SeO(3))(2)Cl(2) at Sakai-Takahashi phase diagram.

Sci Rep

2021 Jul 22

Kozlyakova ES, Moskin AV, Berdonosov PS

231. Conversion from epithelial to partial-EMT phenotype by Fusobacterium nucleatum infection promotes invasion of oral cancer cells.

Sci Rep

2021 Jul 22

Shao W(#), Fujiwara N(#), Mouri Y

232. High repetition rate green-pumped supercontinuum generation in calcium fluoride.

Sci Rep

2021 Jul 22

Marčiulionytė V, Jukna V, Tamošauskas G

233. Photocontrolled apoptosis induction using precursor miR-664a and an RNA carrier-conjugated with photosensitizer.

Sci Rep

2021 Jul 22

Watanabe K, Nawachi T, Okutani R

234. Management of biliary diseases after the failure of initial needle knife precut sphincterotomy for biliary cannulation.

Sci Rep

2021 Jul 22

Lo MH, Lin CH, Wu CH

235. Convenience of Hgb-O detected by optical method in XN-series hematology analyzers in evaluating hemoglobin concentration in samples with chylous turbidity.

Sci Rep

2021 Jul 22

Aruga Y, Ikeda C, Hanai A

236. Gut microbial communities associated with phenotypically divergent populations of the striped stem borer Chilo suppressalis (Walker, 1863).

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2021 Jul 22

Zhong H, Zhang J, Li F

237. Distribution of deadwood and other forest structural indicators relevant for bird conservation in Natura 2000 special protection areas in Poland.

Sci Rep

2021 Jul 22

Bujoczek L, Bujoczek M, Zięba S.

Numerous bird species, often rare or endangered, rely on the presence of standing and downed deadwood for shelter, nesting, and foraging. Habitat quality was evaluated on the basis of deadwood volume, the density of large standing deadwood, and the space filling index (SFI). The SFI reflects the degree of space filling of the bottom layers taking into account tree trunks, seedlings, saplings, ground vegetation, stumps, and downed deadwood. Analysis encompassed all special protection areas (SPAs) in Poland (a total of 107 SPAs containing 7974 sample plots monitored under the National Forest Inventory). An additional in-depth analysis was conducted for 30 SPAs with the greatest share of forest habitats. The studied indicators varied substantially both between and within individual SPAs, with deadwood volume ranging from 1.3 to 50.5 m3 ha-1 (mean of 9.0 m3 ha-1) and the density of large standing deadwood (diameter at breast height ≥ 30 cm) from 0.1 to 16.0 ind ha-1 (mean of 2.2 ind ha-1). These values were relatively low compared to the density of living trees with corresponding dimensions (111 ind ha-1). SFI analysis indicated high or very high space filling of the bottom forest layers on 14-56% of sample plots in a given SPA. The presence of deadwood was found to be significantly positively affected by SPA location in the mountains, a greater proportion of sites with higher fertility, a greater share of forest area under strict protection, as well as higher stand volume within a given SPA. The correlation between deadwood volume and the density of birds (primary and secondary cavity nesters) in individual SPAs was positive (R = 0.60). As compared to lowland areas, SPAs in mountain areas are generally characterized by high stand volumes, a greater density of large living trees, and a greater amount of diverse deadwood. In those areas conservation measures should involve continuous monitoring and diagnosing of any problems associated with the populations of individual bird species; focused efforts should be implemented to support those species that exhibit unfavorable population trends. In most lowland SPAs measures aimed at the improvement of site conditions for birds must be more extensive than in the mountains, with a low abundance of dead trees (especially large ones). These parameters can be improved by retaining some senescent stands in managed forests until their natural death and implementing a strict protection regime in areas of high conservation value.

238. Pulsation of anastomotic vortex veins in pachychoroid spectrum diseases.

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2021 Jul 22

Matsumoto H, Hoshino J, Mukai R

239. Expression patterns and prognostic value of RUNX genes in kidney cancer.

Sci Rep

2021 Jul 22

Gao K(#), Zhang F(#), Chen K(#)

240. Quantification of measurable residual disease in patients with multiple myeloma based on the IMWG response criteria.

Sci Rep

2021 Jul 22

Narita K, Miura D, Tsushima T

241. Role of MCP-1 and IL-8 in viral anterior uveitis, and contractility and fibrogenic activity of trabecular meshwork cells.

Sci Rep

2021 Jul 22

Lee J, Choi JA, Ju HH

242. Gut microbiota-generated metabolite, trimethylamine-N-oxide, and subclinical myocardial damage: a multicenter study from Thailand.

Sci Rep

2021 Jul 22

Senthong V, Kiatchoosakun S, Wongvipaporn C

243. Generation and first characterization of TRDC-knockout pigs lacking γδ T cells.

Sci Rep

2021 Jul 22

Petersen B(#), Kammerer R(#), Frenzel A

244. Cannabis constituents interact at the drug efflux pump BCRP to markedly increase plasma cannabidiolic acid concentrations.

Sci Rep

2021 Jul 22

Anderson LL, Etchart MG, Bahceci D

245. Tyrosine and Tryptophan vibrational bands as markers of kidney injury: a renocardiac syndrome induced by renal ischemia and reperfusion study.

Sci Rep

2021 Jul 22

Nepomuceno G, Junho CVC, Carneiro-Ramos MS

246. Bioprocess development for biosorption of cobalt ions and Congo red from aquatic mixture using Enteromorpha intestinalis biomass as sustainable biosorbent.

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2021 Jul 22

El-Naggar NE, Hamouda RA, Abuelmagd MA

247. Linoleic and oleic acids enhance cell migration by altering the dynamics of microtubules and the remodeling of the actin cytoskeleton at the leading edge.

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2021 Jul 22

Masner M, Lujea N, Bisbal M

248. Analysis of variant-pairing tendencies in lenticular martensite microstructures based on rank-1 connection.

Sci Rep

2021 Jul 22

Shinohara Y, Akabane S, Inamura T.

249. PET/MRI of glucose metabolic rate, lipid content and perfusion in human brown adipose tissue.

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2021 Jul 22

Lundström E, Andersson J, Engström M

250. Surface microstructures developed on polished quartz crystals embedded in wet quartz sand compacted under hydrothermal conditions.

Sci Rep

2021 Jul 21

Schutjens PM, Spiers CJ, Rik Niemeijer A.

Intergranular pressure solution plays a key role as a deformation mechanism during diagenesis and in fault sealing and healing. Here, we present microstructural observations following experiments conducted on quartz aggregates under conditions known to favor pressure solution. We conducted two long term experiments in which a quartz crystal with polished faces of known crystallographic orientation was embedded in a matrix of randomly oriented quartz sand grains. For about two months an effective axial stress of 15 MPa was applied in one experiment, and an effective confining pressure of 28 MPa in the second. Loading occurred at 350 °C in the presence of a silica-saturated aqueous solution. In the first experiment, quartz sand grains in contact with polished quartz prism ([Formula: see text]) faces became ubiquitously truncated against these faces, without indenting or pitting them. By contrast, numerous sand-grain-shaped pits formed in polished pyramidal ([Formula: see text]) and ([Formula: see text]) crystal faces in the second experiment. In addition, four-leaved and (in some cases) three-leafed clover-shaped zones of precipitation formed on these prism faces, in a consistent orientation and pattern around individual pits. The microstructures observed in both experiments were interpreted as evidence for the operation of intergranular pressure solution. The dependence of the observed indentation/truncation microstructures on crystal face orientation can be explained by crystallographic control of stress-induced quartz dissolution kinetics, in line with previously published experimental and petrographic data, or possibly by an effect of contact orientation on the stress-induced driving force for pressure solution. This should be investigated in future experiments, providing data and microstructures which enable further mechanism-based analysis of deformation by pressure solution and the effect of crystallographic control on its kinetics in quartz-rich sands and sandstones.

251. Mesenchymal stem cell-derived exosomes protect trabecular meshwork from oxidative stress.

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2021 Jul 21

Li YC, Zheng J, Wang XZ

252. Understanding of remora's "hitchhiking" behaviour from a hydrodynamic point of view.

Sci Rep

2021 Jul 21

Xu Y, Shi W, Arredondo-Galeana A

253. Minimal-moderate variation of human oral virome and microbiome in IgA deficiency.

Sci Rep

2021 Jul 21

de la Cruz Peña MJ, Gonzalez-Granado LI, Garcia-Heredia I

254. Psychopathic traits mediate guilt-related anterior midcingulate activity under authority pressure.

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2021 Jul 21

Cheng Y(#), Chou J(#), Martínez RM

255. Male sex is not an independent risk factor for recurrence of differentiated thyroid cancer: a propensity score-matching study.

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2021 Jul 21

Park J, Kim K, Lim DJ

256. Automated scoring for a Tablet-based Rey Figure copy task differentiates constructional, organisational, and motor abilities.

Sci Rep

2021 Jul 21

Petilli MA, Daini R, Saibene FL

257. Development of edible Thai rice film fortified with ginger extract using microwave-assisted extraction for oral antimicrobial properties.

Sci Rep

2021 Jul 21

Utama-Ang N, Sida S, Wanachantararak P

258. Yoga versus massage in the treatment of aromatase inhibitor-associated knee joint pain in breast cancer survivors: a randomized controlled trial.

Sci Rep

2021 Jul 21

Tsai CL, Liu LC, Liao CY

259. Increased medial prefrontal cortical thickness and resilience to traumatic experiences in North Korean refugees.

Sci Rep

2021 Jul 21

Jeong H, Lee YJ, Kim N

260. On the robustness of inference of association with the gut microbiota in stool, rectal swab and mucosal tissue samples.

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2021 Jul 21

Sun S, Zhu X, Huang X

261. AST to Platelet Ratio Index (APRI) is an easy-to-use predictor score for cardiovascular risk in metabolic subjects.

Sci Rep

2021 Jul 21

De Matteis C, Cariello M, Graziano G

262. A multi-hazard map-based flooding, gully erosion, forest fires, and earthquakes in Iran.

Sci Rep

2021 Jul 21

Pouyan S, Pourghasemi HR, Bordbar M

263. The effect of empirical and laboratory-confirmed tuberculosis on treatment outcomes.

Sci Rep

2021 Jul 21

Abdullahi O, Moses N, Sanga D

The World Health Organization (WHO) criteria for diagnosing and treating Tuberculosis (TB) includes clinical signs, therefore not requiring bacteriological laboratory confirmation. In resource-limited settings, including Kenya, this empirical TB treatment is routine practice however limited data exist on patient clinical outcomes when comparing the method of diagnosis. We evaluated TB treatment outcomes comparing clinically diagnosed and bacteriologically confirmed TB, 6 months after starting treatment of TB in a rural county in Kenya. Our analysis compared patients with a clinical versus a bacteriologically confirmed TB diagnosis. In this retrospective analysis, we included all adults (≥ 18 years) starting treatment of TB and followed up for 6 months, within the County TB surveillance database from 2012 to 2018. Patients included from both public and private facilities. The TB treatment outcomes assessed included treatment success, treatment failure, death, defaulted and transferred out. We used survival regression models to assess effect of type of diagnosis on TB treatment outcome defining time at risk from date of starting treatment to experiencing one of the treatment outcomes or completing 6-months of treatment. A total of 12,856 patients; median age 37 [IQR 28 - 50] years were included. 7639 (59%) were male while 11,339 (88%) were pulmonary TB cases. Overall, 11,633 (90%) were given first-line TB treatment and 3791 (29%) were HIV infected. 6472 (50%) of the patients were clinically diagnosed of whom 4521/6472 (70%) had a negative sputum/GeneXpert test. During the study 5565 person-years (PYs) observed, treatment success was 82% and 83% amongst clinically and bacteriologically diagnosed patients (P = 0.05). There were no significant differences in defaulting (P = 0.70) or transfer out (P = 0.19) between clinically and bacteriologically diagnosed patients. Mortality was significantly higher among clinically diagnosed patients: 639 (9.9%) deaths compared to 285 (4.5%) amongst the bacteriologically diagnosed patients; aHR 5.16 (95%CI 2.17 - 12.3) P < 0.001. Our study suggests survival during empirical TB treatment is significantly lower compared to patients with laboratory evidence, irrespective of HIV status and age. To improve TB treatment outcomes amongst clinically diagnosed patients, we recommend systematic screening for comorbidities, prompt diagnosis and management of other infections.

264. VHL suppresses RAPTOR and inhibits mTORC1 signaling in clear cell renal cell carcinoma.

Sci Rep

2021 Jul 21

Ganner A, Gehrke C, Klein M

265. SHH-N non-canonically sustains androgen receptor activity in androgen-independent prostate cancer cells.

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2021 Jul 21

Trnski D, Sabol M, Tomić S

266. Associations between lipids in selected brain regions, plasma miRNA, and behavioral and cognitive measures following (28)Si ion irradiation.

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2021 Jul 21

Minnier J, Emmett MR, Perez R

267. APOE E4 is associated with hyperlipidemia and obesity in elderly schizophrenic patients.

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2021 Jul 20

Li W(#), Liu F(#), Liu R(#)

Obesity is a critical issue in patients with schizophrenia, which is considered to be brought about by both environmental and genetic factors. Apolipoprotein E (APOE) gene polymorphisms might be involved in the pathogenesis of schizophrenia, however, the effect of APOE gene polymorphism on obesity has never been investigated in Chinese aging with schizophrenia. This cross-sectional study was to investigate the effect of obesity on cognitive and psychiatric symptoms in elderly participants with schizophrenia. At the same time, we also discussed the inner link between APOE E4 and obesity. 301 elderly participants with schizophrenia and 156 normal controls were included in the study. Their cognitive function was assessed using the Montreal Cognitive Assessment (MoCA), psychiatric symptoms were assessed using the Positive and Negative Syndrome Scale (PANSS), and APOE gene polymorphism was determined by polymerase chain reaction (PCR). The prevalence of obesity in elderly schizophrenic patients and healthy controls accounted for 15.9% (48/301) and 10.3% (16/156), respectively, with no statistically significant difference. By using stepwise linear regression analysis, we found that elevated fasting blood glucose, hypertension, and hyperlipidemia were risk factors for obesity in elderly schizophrenic patients. Although there was no direct correlation between APOE E4 and obesity in patients with schizophrenia, it was significantly correlated with hyperlipemia(r = - 0.154, p = 0.008), suggesting that APOE E4 may induce obesity in elderly patients with schizophrenia through hyperlipemia, However, the above conclusions do not apply to the normal elderly. What's more, we did not find a link between obesity and cognitive function or mental symptoms for both patients with schizophrenia and normal controls. APOE E4 is associated with hyperlipidemia in elderly schizophrenic patients, which may be a risk factor for obesity, however, the above conclusion does not apply to the normal elderly.

268. Nomogram and a predictive model for postoperative hemorrhage in preoperative patients of laparoscopic pancreaticoduodectomy.

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2021 Jul 20

Li D, Du C, Zhang J

269. The impact of different thresholds on optical coherence tomography angiography images binarization and quantitative metrics.

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2021 Jul 20

Arrigo A, Aragona E, Saladino A

270. Spontaneous myogenic fasciculation associated with the lengthening of cardiac muscle in response to static preloading.

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2021 Jul 20

Fan S, Gao L, Bell AC

271. Simple and cost-effective microfabrication of flexible and stretchable electronics for wearable multi-functional electrophysiological monitoring.

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2021 Jul 20

Kim CH, Lee DH, Youn J

272. Development of a system to support warfarin dose decisions using deep neural networks.

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2021 Jul 20

Lee H(#), Kim HJ(#), Chang HW

273. A sequence variant in the diacylglycerol O-acyltransferase 2 gene influences palmitoleic acid content in pig muscle.

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2021 Jul 20

Solé E, Ros-Freixedes R, Tor M

274. Comparative transcriptomic analysis of two Saccharopolyspora spinosa strains reveals the relationships between primary metabolism and spinosad production.

Sci Rep

2021 Jul 20

Zhang Y(#), Liu X(#), Yin T

275. SpheroidPicker for automated 3D cell culture manipulation using deep learning.

Sci Rep

2021 Jul 20

Grexa I, Diosdi A, Harmati M

276. Complex shaped periodic corrugations for broadband Bull's Eye antennas.

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2021 Jul 20

Kampouridou D, Feresidis A.

277. Probing cerebellar involvement in cognition through a meta-analysis of TMS evidence.

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2021 Jul 20

Gatti D, Rinaldi L, Cristea I

278. Peptide VSAK maintains tissue glucose uptake and attenuates pro-inflammatory responses caused by LPS in an experimental model of the systemic inflammatory response syndrome: a PET study.

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2021 Jul 20

Luna-Reyes I, Pérez-Hernández EG, Delgado-Coello B

279. Synthesis of bimetallic nanoparticles loaded on to PNIPAM hybrid microgel and their catalytic activity.

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2021 Jul 20

Kakar MU, Khan K, Akram M

280. Low hemoglobin levels and an increased risk of psoriasis in patients with chronic kidney disease.

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2021 Jul 20

Lee SH, Kim M, Han KD

281. Induction of cell wall phenolic monomers as part of direct defense response in maize to pink stem borer (Sesamia inferens Walker) and non-insect interactions.

Sci Rep

2021 Jul 20

Soujanya PL, Sekhar JC, Ratnavathi CV

Pink stem borer (PSB) causes considerable yield losses to maize. Plant-insect interactions have significant implications for sustainable pest management. The present study demonstrated that PSB feeding, mechanical wounding, a combination of mechanical wounding and PSB regurgitation and exogenous application of methyl jasmonate have induced phenolic compound mediated defense responses both at short term (within 2 days of treatment) and long term (in 15 days of treatment) in leaf and stalk tissues of maize. The quantification of two major defense related phenolic compounds namely p-Coumaric acid (p-CA) and ferulic acid (FA) was carried out through ultra-fast liquid chromatography (UFLC) at 2 and 15 days after imposing the above treatments. The p-CA content induced in leaf tissues of maize genotypes were intrinsically higher when challenged by PSB attack at V3 and V6 stages in short- and long-term responses. Higher p-CA content was observed in stalk tissues upon wounding and regurgitation in short- and long-term responses at V3 and V6 stages. Significant accumulation of FA content was also observed in leaf tissues in response to PSB feeding at V3 stage in long-term response while at V6 stage it was observed both in short- and long-term responses. In stalk tissues, methyl jasmonate induced higher FA content in short-term response at V3 stage. However, at V6 stage PSB feeding induced FA accumulation in the short-term while, wounding and regurgitation treatment-induced defense responses in the long-term. In general, the resistant (DMRE 63, CM 500) and moderately resistant genotypes (WNZ ExoticPool) accumulated significantly higher contents of p-CA and FA content than susceptible ones (CM 202, BML 6) in most of the cases. The study indicates that phenolic mediated defense responses in maize are induced by PSB attack followed by wounding and regurgitation compared to the other induced treatments. Furthermore, the study confirmed that induced defense responses vary with plant genotype, stage of crop growth, plant tissue and short and long-term responses. The results of the study suggested that the Phenolic acids i.e. p-CA and FA may contribute to maize resistance mechanisms in the maize-PSB interaction system.

282. Garlic (Allium sativum)-derived SEVs inhibit cancer cell proliferation and induce caspase mediated apoptosis.

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2021 Jul 20

Özkan İ, Koçak P, Yıldırım M

283. Syncing sustainable urban mobility with public transit policy trends based on global data analysis.

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2021 Jul 20

Ceder AA.

284. Investigation of single-domain Au silicide nanowires on Si(110) formed for Au coverages in the monolayer regime.

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2021 Jul 20

Appelfeller S.

285. Quantification of pedogenic particles masked by geogenic magnetic fraction.

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2021 Jul 20

Szuszkiewicz M, Grison H, Petrovský E

286. Enhancing reappraisal of negative emotional memories with transcranial direct current stimulation.

Sci Rep

2021 Jul 20

Doerig N(#), Seinsche RJ(#), Moisa M

287. Whole genome sequencing of nearly isogenic WMI and WLI inbred rats identifies genes potentially involved in depression and stress reactivity.

Sci Rep

2021 Jul 20

de Jong TV, Kim P, Guryev V

288. Angle-insensitive co-polarized metamaterial absorber based on equivalent circuit analysis for dual band WiFi applications.

Sci Rep

2021 Jul 2

Hannan S, Islam MT, Faruque MRI

289. The effects of body position and actual execution on motor imagery of locomotor tasks in people with a lower-limb amputation.

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2021 Jul 2

Saimpont A, Malouin F, Durand A

290. A systematic review and meta-analysis of association between brain-derived neurotrophic factor and type 2 diabetes and glycemic profile.

Sci Rep

2021 Jul 2

Davarpanah M, Shokri-Mashhadi N, Ziaei R

Several epidemiologic studies have evaluated the relation between serum/plasma brain-derived neurotrophic factor (BDNF) levels and glycemic parameters, but the findings were conflicting. We performed a systematic review and meta-analysis to compare circulating BDNF levels in individuals with type 2 diabetes (T2D) or other glycemic disorders with healthy controls and to evaluate correlation between BDNF concentrations with glycemic profile. A systematic search up to July 2020 was conducted in reliable electronic databases (MEDLINE (Pubmed), EMBASE, Scopus) and Google scholar. Sixteen observational studies compared serum/plasma BDNF levels in diabetic patients (or individuals with glycemic disorders) vs. healthy controls or reported correlations between serum BDNF levels and glycemic parameters in adults were included in the review. Overall weighted mean difference (WMD) of circulating BDNF levels in 1306 patients with T2D (or other glycemic disorders) was 1.12 ng/mL lower than 1250 healthy subjects (WMD: - 1.12; 95%CI - 1.37, - 0.88, I2 = 98.7%, P < 0.001). Subgroup analysis revealed that both diabetic patients and subjects with other glycemic disorders had lower serum/plasma BDNF levels than healthy controls (WMD: - 1.74; 95%CI - 2.15, - 1.33 and WMD: - 0.49; 95%CI - 0.82, - 0.16, respectively). No significant correlation was found between BDNF levels and glycemic parameters [fasting blood glucose (FBG) (Fisher's Z = 0.05; 95%CI - 0.21, 0.11; n = 1400), homeostatic model assessment for insulin resistance (HOMA-IR) (Fisher's Z = 0.12; 95%CI - 0.20, 0.44; n = 732) and glycosylated hemoglobin (HbA1c) (Fisher's Z = 0.04; 95%CI - 0.05, 0.12; n = 2222)]. We found that diabetic patients and subjects with glycemic disorders had lower circulating BDNF levels than healthy controls. However, there was no significant correlation between BDNF concentrations and glycemic parameters including FBG, HOMA-IR and HbA1c. Further prospective investigations are required to confirm these findings.

291. Membrane vesicles of Lacticaseibacillus rhamnosus JB-1 contain immunomodulatory lipoteichoic acid and are endocytosed by intestinal epithelial cells.

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2021 Jul 2

Champagne-Jorgensen K, Mian MF, McVey Neufeld KA

292. Statistical learning of target selection and distractor suppression shape attentional priority according to different timeframes.

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2021 Jul 2

Di Caro V, Della Libera C.

293. Genetic basis and network underlying synergistic roots and shoots biomass accumulation revealed by genome-wide association studies in rice.

Sci Rep

2021 Jul 2

Zhao Y(#), Yin Z(#), Wang X(#)

294. Distinct roles of androgen receptor, estrogen receptor alpha, and BCL6 in the establishment of sex-biased DNA methylation in mouse liver.

Sci Rep

2021 Jul 2

AlOgayil N, Bauermeister K, Galvez JH

295. Association between overactive bladder and pelvic organ mobility as evaluated by dynamic magnetic resonance imaging.

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2021 Jul 2

Kinno K, Sekido N, Takeuchi Y

296. Statistical and machine learning methods for analysis of multiplex protein data from a novel proximity extension assay in patients with ST-elevation myocardial infarction.

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2021 Jul 2

Maag E, Kulasingam A, Grove EL

297. Interlaboratory study for the evaluation of three microtiter plate-based biofilm quantification methods.

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2021 Jul 2

Allkja J, van Charante F, Aizawa J

298. Prokineticin 1-prokineticin receptor 1 signaling in trophoblast promotes embryo implantation and placenta development.

Sci Rep

2021 Jul 2

Goryszewska-Szczurek E, Baryla M, Kaczynski P

299. An efficient and secure protocol for checking remote data integrity in multi-cloud environment.

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2021 Jul 2

Anwarbasha H, Sasi Kumar S, Dhanasekaran D.

300. Identification of new GLUT2-selective inhibitors through in silico ligand screening and validation in eukaryotic expression systems.

Sci Rep

2021 Jul 2

Schmidl S(#), Ursu O(#), Iancu CV

301. OpenHSV: an open platform for laryngeal high-speed videoendoscopy.

Sci Rep

2021 Jul 2

Kist AM, Dürr S, Schützenberger A

302. Three-dimensional virtual histology in unprocessed resected tissues with photoacoustic remote sensing (PARS) microscopy and optical coherence tomography (OCT).

Sci Rep

2021 Jul 2

Ecclestone BR, Hosseinaee Z, Abbasi N

303. Linkage mapping and QTL analysis of flowering time in faba bean.

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2021 Jul 2

Aguilar-Benitez D, Casimiro-Soriguer I, Maalouf F

304. Mobility restrictions were associated with reductions in COVID-19 incidence early in the pandemic: evidence from a real-time evaluation in 34 countries.

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2021 Jul 2

Oh J, Lee HY, Khuong QL

305. The Rayleigh-Lorentz invariant for superconducting resonators and optimal adiabatic qubit-information detection.

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2021 Jul 2

Choi JR.

306. Characterization of resistance and fitness cost of Descurainia sophia L. populations from Henan and Xinjiang, China.

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2021 Jul 19

Li D, Xie L, Zhang P

307. Analyzing the link between anxiety and eating behavior as a potential pathway to eating-related health outcomes.

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2021 Jul 19

Hussenoeder FS, Conrad I, Engel C

308. Heat source free water floating carbon nanotube thermoelectric generators.

Sci Rep

2021 Jul 19

Chiba T, Amma Y, Takashiri M.

309. COVID-19 lockdown has altered the dynamics between affective symptoms and social isolation among older adults: results from a longitudinal network analysis.

Sci Rep

2021 Jul 19

Yu J, Mahendran R.

310. Comparison of an oblique single cut rotation osteotomy with a novel 3D computer-assisted oblique double cut alignment approach.

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2021 Jul 19

Dobbe JGG, Kloen P, Strackee SD

311. Outer retinal tubulation formation and clinical course of advanced age-related macular degeneration.

Sci Rep

2021 Jul 19

Arrigo A, Aragona E, Battaglia O

Outer retinal tubulations (ORT) are a relatively new finding characterizing outer retinal atrophy. The main aim of the present study was to describe ORT development in advanced age-related macular degeneration (AMD) and to assess its relationship with disease's severity. Patients with advanced AMD characterized either by macular neovascularization or geographic atrophy, showing signs of outer retinal disruption or retinal pigment epithelium atrophy on structural optical coherence tomography (OCT) at the inclusion examination were prospectively recruited. All the patients underwent complete ophthalmologic evaluation, structural OCT scans and fundus autofluorescence imaging. The planned follow-up was of 3-years. Main outcome measures were ORT prevalence, mechanism of ORT formation, mean time needed for complete ORT formation, best-corrected visual acuity (BCVA), definitely decreased autofluorescence (DDAF) area, questionably decreased autofluorescence (QDAF) area, retinal layer thickness, foveal sparing, number of intravitreal injections. We also assessed the possible role of external limiting membrane (ELM) and Müller cells in ORT pathogenesis. Seventy eyes (70 patients) were included; 43 showed dry AMD evolving to geographic atrophy, while 27 displayed the features of wet AMD. Baseline BCVA was 0.5 ± 0.5 LogMAR, decreasing to 0.9 ± 0.5 LogMAR at the 3-year follow-up (p < 0.01). We detected completely formed ORT in 26/70 eyes (37%), subdivided as follows: 20 eyes (77%) wet AMD and 6 eyes (23%) dry AMD (p < 0.01). ORT took 18 ± 8 months (range 3-35 months) to develop fully. We described the steps leading to ORT development, characterized by progressive involvement of, and damage to the photoreceptors, the ELM and the RPE. Eyes displaying ORT were associated with a smaller QDAF area, less retinal layers damage and lower rate of foveal sparing than eyes free of ORT (p < 0.01). We also described pigment accumulations simulating ORT, which were detected in 16/70 eyes (23%), associated with a greater loss of foveal sparing, increased DDAF area and smaller QDAF area at the 3-year follow-up (p < 0.01). In conclusion, this study provided a description of the steps leading to ORT development in AMD. ELM and Müller cells showed a role in ORT pathogenesis. Furthermore, we described a subtype of pigment hypertrophy mimicking ORT, evaluating its clinical utility.

312. Blood glutamate scavengers increase pro-apoptotic signaling and reduce metastatic melanoma growth in-vivo.

Sci Rep

2021 Jul 19

Goldshmit Y, Perelroizen R, Yakovchuk A

313. Silica and graphene mediate arsenic detection in mature rice grain by a newly patterned current-volt aptasensor.

Sci Rep

2021 Jul 19

Uda MNA, Gopinath SCB, Hashim U

314. Effects of different straw biochar combined with microbial inoculants on soil environment in pot experiment.

Sci Rep

2021 Jul 19

Qi Y, Liu H, Wang J

315. Entropy production and mixed convection within trapezoidal cavity having nanofluids and localised solid cylinder.

Sci Rep

2021 Jul 19

Ishak MS, Alsabery AI, Hashim I

316. Skin tolerant inactivation of multiresistant pathogens using far-UVC LEDs.

Sci Rep

2021 Jul 19

Glaab J(#), Lobo-Ploch N(#), Cho HK

317. The role of ascorbic acid combined exposure on Imidacloprid-induced oxidative stress and genotoxicity in Nile tilapia.

Sci Rep

2021 Jul 19

El-Garawani IM, Khallaf EA, Alne-Na-Ei AA

Imidacloprid (Imid), a systemic neonicotinoid insecticide, is broadly used worldwide. It is reported to contaminate aquatic systems. This study was proposed to evaluate oxidative stress and genotoxicity of Imid on Nile tilapia (Oreochromis niloticus) and the protective effect of ascorbic acid (Asc). O. niloticus juveniles (30.4 ± 9.3 g, 11.9 ± 1.3 cm) were divided into six groups (n = 10/replicate). For 21 days, two groups were exposed to sub-lethal concentrations of Imid (8.75 ppm, 1/20 of 72 h-LC50 and 17.5 ppm, 1/10 of 72 h-LC50); other two groups were exposed to Asc (50 ppm) in combination with Imid (8.75 and 17.5 ppm); one group was exposed to Asc (50 ppm) in addition to a group of unexposed fish which served as controls. Oxidative stress was assessed in the liver where the level of enzymatic activities including superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPX) in addition to mRNA transcripts and, Lipid peroxidation (LPO) were evaluated. Moreover, mitotic index (MI) and comet assay were performed, in addition, the erythrocytic micronucleus (MN), and nuclear abnormalities (NA) were observed to assess genotoxicity in fish. Imid exposure induced significant (p ˂ 0.05) changes in the antioxidant profile of the juveniles' liver by increasing the activities and gene expression of SOD, CAT and GPX as well as elevating the levels of LPO. DNA strand breaks in gill cells, erythrocytes and hepatocytes along with erythrocytic MN and NA were also significantly elevated in Imid-exposed groups. MI showed a significant (p ˂ 0.05) decrease associated with Imid exposure. Asc administration induced a significant amelioration towards the Imid toxicity (8.75 and 17.5 ppm). A significant protective potency against the genotoxic effects of Imid was evidenced in Asc co-treated groups. Collectively, results highlight the importance of Asc as a protective agent against Imid-induced oxidative stress and genotoxicity in O. niloticus juveniles.

318. Elevated S-adenosylhomocysteine induces adipocyte dysfunction to promote alcohol-associated liver steatosis.

Sci Rep

2021 Jul 19

Arumugam MK, Chava S, Rasineni K

319. Low pan-immune-inflammation-value predicts better chemotherapy response and survival in breast cancer patients treated with neoadjuvant chemotherapy.

Sci Rep

2021 Jul 19

Şahin AB, Cubukcu E, Ocak B

Blood-based biomarkers reflect systemic inflammation status and have prognostic and predictive value in solid malignancies. As a recently defined biomarker, Pan-Immune-Inflammation-Value (PIV) integrates different peripheral blood cell subpopulations. This retrospective study of collected data aimed to assess whether PIV may predict the pathological complete response (pCR) to neoadjuvant chemotherapy (NAC) in Turkish women with breast cancer. The study consisted of 743 patients with breast cancer who were scheduled to undergo NAC before attempting cytoreductive surgery. A pre-treatment complete blood count was obtained in the two weeks preceding NAC, and blood-based biomarkers were calculated from absolute counts of relevant cell populations. The pCR was defined as the absence of tumor cells in both the mastectomy specimen and lymph nodes. Secondary outcome measures included disease-free survival (DFS) and overall survival (OS). One hundred seven patients (14.4%) had pCR. In receiver operating characteristic analysis, optimal cut-off values for the neutrophile-to-lymphocyte ratio (NLR), monocyte-to-lymphocyte ratio (MLR), platelet-to-lymphocyte (PLR), PIV, and Ki-67 index were determined as ≥ 2.34, ≥ 0.22, ≥ 131.8, ≥ 306.4, and ≥ 27, respectively. The clinical tumor (T) stage, NLR, MLR, PLR, PIV, estrogen receptor (ER) status, human epidermal growth factor receptor-2 (HER-2) status, and Ki-67 index were significantly associated with NAC response in univariate analyses. However, multivariate analysis revealed that the clinical T stage, PIV, ER status, HER-2 status, and Ki-67 index were independent predictors for pCR. Moreover, the low PIV group patients had significantly better DFS and OS than those in the high PIV group (p = 0.034, p = 0.028, respectively). Based on our results, pre-treatment PIV seems as a predictor for pCR and survival, outperforming NLR, MLR, PLR in predicting pCR in Turkish women with breast cancer who received NAC. However, further studies are needed to confirm our findings.

320. Genetic characterization and implications for conservation of the last autochthonous Mouflon population in Europe.

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2021 Jul 19

Satta V(#), Mereu P(#), Barbato M

321. Homogeneous 2D and 3D alignment of cardiomyocyte in dilated cardiomyopathy revealed by intravital heart imaging.

Sci Rep

2021 Jul 19

Masuyama K(#), Higo T(#), Lee JK

322. Metagenomic identification of a new sarbecovirus from horseshoe bats in Europe.

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2021 Jul 19

Crook JM(#), Murphy I(#), Carter DP

323. Comparative and phylogenetic analyses of the chloroplast genomes of species of Paeoniaceae.

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2021 Jul 19

Wu L, Nie L, Wang Q

324. Implication of FDG-PET/CT without synchronous colonic lesion in patients with stenotic left-sided colorectal cancer.

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2021 Jul 19

Lee JI, Cho SS, Shin US

325. Metabolic factors and the risk of Dupuytren's disease: data from 30,000 individuals followed for over 20 years.

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2021 Jul 19

Rydberg M, Zimmerman M, Löfgren JP

326. Glomerular function in relation to fine airborne particulate matter in a representative population sample.

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2021 Jul 19

Feng YM, Thijs L, Zhang ZY

327. Rate of decline in kidney function and known age-of-onset or duration of type 2 diabetes.

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2021 Jul 19

Buyadaa O, Salim A, Morton JI

328. Stepwise neuronal network pattern formation in agarose gel during cultivation using non-destructive microneedle photothermal microfabrication.

Sci Rep

2021 Jul 19

Tanaka Y(#), Watanabe H(#), Shimoda K

329. Ipsilateral somatic nerves mediate histamine-induced vasosensory reflex responses involving perivascular afferents in rat models.

Sci Rep

2021 Jul 19

Revand R, Singh SK.

330. Influence of exposure conditions on helium transport and bubble growth in tungsten.

Sci Rep

2021 Jul 19

Delaporte-Mathurin R, Ialovega M, Hodille EA

331. Age period cohort analysis of chewing ability in Korea from 2007 to 2018.

Sci Rep

2021 Jul 19

Kim NH, Kawachi I.

332. Efficient-CapsNet: capsule network with self-attention routing.

Sci Rep

2021 Jul 19

Mazzia V, Salvetti F, Chiaberge M.

333. Development and validation in 500 female samples of a TP-PCR assay to identify AFF2 GCC expansions.

Sci Rep

2021 Jul 19

Silva C(#), Maia N(#), Santos F

Over 100 X-linked intellectual disability genes have been identified, with triplet repeat expansions at the FMR1 (FRAXA) and AFF2 (FRAXE) genes being the causative agent in two of them. The absence of FRAXE pathognomonic features hampers early recognition, delaying testing and molecular confirmation. Hence, our laboratory uses a multiplex PCR-based strategy to genotype both FRAXA and FRAXE. However, AFF2 expansions are missed giving rise to an uninformative result in around 20% of female samples. To rule out undetected expansions and confirm homozygosity Southern blot analysis is performed being labour- and resource-intensive. The aim of this study is to develop a timely and economic triplet-primed amplification (TP-PCR) screening strategy to size the AFF2 GCC repeat and accurately assess homozygosity as well as pinpoint multiplex-PCR false negatives in female samples. In order to achieve this, validation was performed in a cohort of 500 females with a previous uninformative FRAXE PCR result. Interestingly, the presence of a T > C SNP (rs868949662), contiguous to the GCC repetitive tract, allows triplet primer binding in two additional repeats, increasing the discrimination power of the TP-PCR assay in heterozygous and homozygous samples. Twelve alleles outside the normal range were recognized: eight intermediate and four premutated, which seems relevant considering the rarity of the AFF2 expansions. All genotypes are concordant with that obtained by Southern blotting, confirming this as a strict, reproducible and low-cost homozygosity screening strategy that enables the identification of small expanded alleles missed by the routine multiplex-PCR due to allele dropout. Overall, this assay is capable of spotting multiplex-PCR false negatives besides identifying alleles up to > 80 GCC repeats. Furthermore, the occurrence of intermediate repeat sizes with unexpected frequency, introduces new areas of clinical research in this cohort in understanding these less explored AFF2 repeat sizes and newly associated phenotypes.

334. W27 IgA suppresses growth of Escherichia in an in vitro model of the human intestinal microbiota.

Sci Rep

2021 Jul 16

Sasaki K, Mori T, Hoshi N

335. The effect of stretch-shortening magnitude and muscle-tendon unit length on performance enhancement in a stretch-shortening cycle.

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2021 Jul 16

Groeber M, Stafilidis S, Baca A.

336. Coral larval settlement preferences linked to crustose coralline algae with distinct chemical and microbial signatures.

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2021 Jul 16

Jorissen H, Galand PE, Bonnard I

337. Publisher Correction: Genetic dissection of down syndrome‑associated alterations in APP/amyloid‑β biology using mouse models.

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2021 Jul 16

Tosh JL, Rhymes ER, Mumford P

338. Origin of light instability in amorphous IGZO thin-film transistors and its suppression.

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2021 Jul 16

Mativenga M, Haque F, Billah MM

339. Evidence for use of both capital and income breeding strategies in the mangrove tree crab, Aratus pisonii.

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2021 Jul 16

Carver J, Meidell M, Cannizzo ZJ

340. Direct treatment of interaction between laser-field and electrons for simulating laser processing of metals.

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2021 Jul 16

Miyamoto Y.

341. A comprehensive meta-analysis and a case-control study give insights into genetic susceptibility of lung cancer and subgroups.

Sci Rep

2021 Jul 16

Sengupta D(#), Banerjee S(#), Mukhopadhyay P(#)

342. In vitro efficacy of artemisinin-based treatments against SARS-CoV-2.

Sci Rep

2021 Jul 16

Zhou Y(#), Gilmore K(#), Ramirez S

343. Growth arrest and DNA damage-inducible proteins (GADD45) in psoriasis.

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2021 Jul 16

Rodríguez-Jiménez P(#), Fernández-Messina L(#), Ovejero-Benito MC

344. Decoding the molecular mechanism of parthenocarpy in Musa spp. through protein-protein interaction network.

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2021 Jul 16

Backiyarani S, Sasikala R, Sharmiladevi S

345. Morningness-eveningness assessment from mobile phone communication analysis.

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2021 Jul 16

Roy C, Monsivais D, Bhattacharya K

346. Molecular dynamics of rolling and twisting motion of amorphous nanoparticles.

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2021 Jul 16

Umstätter P, Urbassek HM.

347. Anisotropic distortion in the perceived orientation of stimuli on the arm.

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2021 Jul 16

Kuroki S.

348. Insight into diatom frustule structures using various imaging techniques.

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2021 Jul 15

Zgłobicka I, Gluch J, Liao Z

349. Experimental investigation into the effects of composition and microstructure on the tensile properties and failure characteristics of different gypsum rocks.

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2021 Jul 15

Ma H, Chen S, Song Y

350. Fabrication of solderable intense pulsed light sintered hybrid copper for flexible conductive electrodes.

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2021 Jul 15

Jang YR, Jeong R, Kim HS

351. Manipulation of surface charges of oil droplets and carbonate rocks to improve oil recovery.

Sci Rep

2021 Jul 15

Hou J, Han M, Wang J.

352. No association between alcohol consumption and pancreatic cancer even among individuals genetically susceptible to the carcinogenicity of alcohol.

Sci Rep

2021 Jul 15

Shan YS(#), Chen LT(#), Wu CH(#)

353. Crustal structure in the Campanian region (Southern Apennines, Italy) from potential field modelling.

Sci Rep

2021 Jul 15

Kelemework Y, Milano M, La Manna M

354. Medial prefrontal cortex (A32 and A25) projections in the common marmoset: a subcortical anterograde study.

Sci Rep

2021 Jul 15

Ríos-Flórez JA, Lima RRM, Morais PLAG

355. A new charophyte habitat with a stabilized good ecological potential of mine water.

Sci Rep

2021 Jul 15

Napiórkowska-Krzebietke A, Skrzypczak AR.

356. Strictly regulated agonist-dependent activation of AMPA-R is the key characteristic of TAK-653 for robust synaptic responses and cognitive improvement.

Sci Rep

2021 Jul 15

Suzuki A, Kunugi A, Tajima Y

357. Estimation of unsteady hydromagnetic Williamson fluid flow in a radiative surface through numerical and artificial neural network modeling.

Sci Rep

2021 Jul 15

Shafiq A, Çolak AB, Sindhu TN

358. Light modulates important physiological features of Ralstonia pseudosolanacearum during the colonization of tomato plants.

Sci Rep

2021 Jul 15

Tano J(#), Ripa MB(#), Tondo ML

359. Protective effects and mechanisms of high-dose vitamin C on sepsis-associated cognitive impairment in rats.

Sci Rep

2021 Jul 15

Zhang N(#), Zhao W(#), Hu ZJ

360. Unveiling the nature of interaction between semantics and phonology in lexical access based on multilayer networks.

Sci Rep

2021 Jul 14

Levy O(#), Kenett YN(#), Oxenberg O

361. Multiscale criticality measures as general-purpose gauges of proper brain function.

Sci Rep

2021 Jul 14

Fekete T, Hinrichs H, Sitt JD

362. Effect of vestibular exercise and optokinetic stimulation using virtual reality in persistent postural-perceptual dizziness.

Sci Rep

2021 Jul 14

Choi SY, Choi JH, Oh EH

363. Coronary artery segmentation under class imbalance using a U-Net based architecture on computed tomography angiography images.

Sci Rep

2021 Jul 14

Pan LS, Li CW, Su SF

364. Longitudinal monitoring of laboratory markers characterizes hospitalized and ambulatory COVID-19 patients.

Sci Rep

2021 Jul 14

Velavan TP, Kuk S, Linh LTK

365. GIP_HUMAN[22-51] is a new proatherogenic peptide identified by native plasma peptidomics.

Sci Rep

2021 Jul 14

Masaki T, Kodera Y, Terasaki M

366. Defect-induced ferromagnetism in a S = 1/2 quasi-one-dimensional Heisenberg antiferromagnetic chain compound.

Sci Rep

2021 Jul 14

Wang Z, Hu L, Lin L

367. Aerosol microphysics and chemistry reveal the COVID19 lockdown impact on urban air quality.

Sci Rep

2021 Jul 14

Eleftheriadis K, Gini MI, Diapouli E

368. Integrated whole transcriptome and small RNA analysis revealed multiple regulatory networks in colorectal cancer.

Sci Rep

2021 Jul 14

Shaath H, Toor SM, Nada MA

369. Conductance artery stiffness impairs atrio-ventriculo-arterial coupling before manifestation of arterial hypertension or left ventricular hypertrophic remodelling.

Sci Rep

2021 Jul 14

Kyhl K, von Huth S, Bojer A

370. Morphological response accompanying size reduction of belemnites during an Early Jurassic hyperthermal event modulated by life history.

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2021 Jul 14

Nätscher PS, Dera G, Reddin CJ

371. Strain hardening recovery mediated by coherent precipitates in lightweight steel.

Sci Rep

2021 Jul 14

Kim SD, Park SJ, Jang JH

372. Silica nanoparticles as pesticide against insects of different feeding types and their non-target attraction of predators.

Sci Rep

2021 Jul 14

Thabet AF, Boraei HA, Galal OA

373. A system biology approach based on metabolic biomarkers and protein-protein interactions for identifying pathways underlying schizophrenia and bipolar disorder.

Sci Rep

2021 Jul 14

Altaf-Ul-Amin M, Hirose K, Nani JV

374. Clubroot resistance derived from the European Brassica napus cv. 'Tosca' is not effective against virulent Plasmodiophora brassicae isolates from Alberta, Canada.

Sci Rep

2021 Jul 14

Fredua-Agyeman R, Hwang SF, Zhang H

375. Quantitative observation of monochromatic X-rays emitted from implosion hotspot in high spatial resolution in inertial confinement fusion.

Sci Rep

2021 Jul 14

Ren K, Wu J, Dong J

376. Local bi-fidelity field approximation with Knowledge Based Neural Networks for Computational Fluid Dynamics.

Sci Rep

2021 Jul 14

Pepper N, Gaymann A, Sharma S

377. Associations between lifetime classic psychedelic use and cardiometabolic diseases.

Sci Rep

2021 Jul 13

Simonsson O, Osika W, Carhart-Harris R

378. Reasoning supports forgiving accidental harms.

Sci Rep

2021 Jul 13

Patil I, Trémolière B.

379. A longitudinal analysis of COVID-19 lockdown stringency on sleep and resting heart rate measures across 20 countries.

Sci Rep

2021 Jul 13

Ong JL, Lau T, Karsikas M

380. Identification and characterization of a novel Epstein-Barr Virus-encoded circular RNA from LMP-2 Gene.

Sci Rep

2021 Jul 13

Tan KE, Ng WL, Marinov GK

381. Studying dynamic stress effects on the behaviour of THP-1 cells by microfluidic channels.

Sci Rep

2021 Jul 13

Birol SZ, Fucucuoglu R, Cadirci S

382. Biological scaling in green algae: the role of cell size and geometry.

Sci Rep

2021 Jul 13

Bestová H, Segrestin J, von Schwartzenberg K

383. CAD systems for colorectal cancer from WSI are still not ready for clinical acceptance.

Sci Rep

2021 Jul 13

Oliveira SP(#), Neto PC(#), Fraga J(#)

384. Regularized machine learning on molecular graph model explains systematic error in DFT enthalpies.

Sci Rep

2021 Jul 13

Bhattacharjee H, Anesiadis N, Vlachos DG.

385. Fixation eye movement abnormalities and stereopsis recovery following strabismus repair.

Sci Rep

2021 Jul 13

Martin TL, Murray J, Garg K

386. The risk reduction effect of sediment production rate by understory coverage rate in granite area mountain forest.

Sci Rep

2021 Jul 13

Mizuno T, Kojima N, Asano S.

387. Influence of Ile655Val polymorphism on trastuzumab-induced cardiotoxicity in early-stage HER2 positive breast cancer.

Sci Rep

2021 Jul 13

Vazdar L, Gabrić ID, Kruljac I

388. Universal Stokes's nanomechanical viscometer.

Sci Rep

2021 Jul 13

Chaudhary K, Munjal P, Singh KP.

389. COVID-19 mitigation by digital contact tracing and contact prevention (app-based social exposure warnings).

Sci Rep

2021 Jul 13

Soldano GJ, Fraire JA, Finochietto JM

390. Unpalatable plants induce a species-specific associational effect on neighboring communities.

Sci Rep

2021 Jul 13

Erfanian MB, Memariani F, Atashgahi Z

391. Penetration of MeV electrons into the mesosphere accompanying pulsating aurorae.

Sci Rep

2021 Jul 13

Miyoshi Y, Hosokawa K, Kurita S

392. Topographic correlates of driver mutations and endogenous gene expression in pediatric diffuse midline gliomas and hemispheric high-grade gliomas.

Sci Rep

2021 Jul 13

Kazarian E, Marks A, Cui J

393. The impact of a closed-loop thalamocortical model on the spatiotemporal dynamics of cortical and thalamic traveling waves.

Sci Rep

2021 Jul 13

Bhattacharya S, Cauchois MBL, Iglesias PA

394. Tele-EMS physicians improve life-threatening conditions during prehospital emergency missions.

Sci Rep

2021 Jul 13

Schröder H, Beckers SK, Ogrodzki K

Almost seven years ago, a telemedicine system was established as an additional component of the city of Aachen's emergency medical service (EMS). It allows paramedics to engage in an immediate consultation with an EMS physician at any time. The system is not meant to replace the EMS physician on the scene during life-threatening emergencies. The aim of this study was to analyze teleconsultations during life-threatening missions and evaluate whether they improve patient care. Telemedical EMS (tele-EMS) physician consultations that occurred over the course of four years were evaluated. Missions were classified as involving potentially life-threatening conditions based on at least one of the following criteria: documented patient severity score, life-threatening vital signs, the judgement of the onsite EMS physician involved in the mission, or definite life-threatening diagnoses. The proportion of vital signs indicating that the patient was in a life-threatening condition was analyzed as the primary outcome at the start and end of the tele-EMS consultation. The secondary outcome parameters were the administered drug doses, tracer diagnoses made by the onsite EMS physicians during the missions, and quality of the documentation of the missions. From January 2015 to December 2018, a total of 10,362 tele-EMS consultations occurred; in 4,293 (41.4%) of the missions, the patient was initially in a potentially life-threatening condition. Out of those, a total of 3,441 (80.2%) missions were performed without an EMS physician at the scene. Records of 2,007 patients revealed 2,234 life-threatening vital signs of which 1,465 (65.6%) were remedied during the teleconsultation. Significant improvement was detected for oxygen saturation, hypotonia, tachy- and bradycardia, vigilance states, and hypoglycemia. Teleconsultation during missions involving patients with life-threatening conditions can significantly improve those patients' vital signs. Many potentially life-threatening cases could be handled by a tele-EMS physician as they did not require any invasive interventions that needed to be performed by an onsite EMS physician. Diagnoses of myocardial infarction, cardiac pulmonary edema, or malignant dysrhythmias necessitate the presence of onsite EMS physicians. Even during missions involving patients with life-threatening conditions, teleconsultation was feasible and often accessed by the paramedics.

395. Exogenous misfolded protein oligomers can cross the intestinal barrier and cause a disease phenotype in C. elegans.

Sci Rep

2021 Jul 13

Perni M(#), Mannini B(#), Xu CK(#)

396. The foggy effect of egocentric distance in a nonverbal paradigm.

Sci Rep

2021 Jul 13

Dong B(#), Chen A(#), Zhang Y

397. Fabrication of the macro and micro-scale microbial fuel cells to monitor oxalate biodegradation in human urine.

Sci Rep

2021 Jul 12

Yousefi R, Mardanpour MM, Yaghmaei S.

398. Prediction of a positive surgical margin and biochemical recurrence after robot-assisted radical prostatectomy.

Sci Rep

2021 Jul 12

Yang CW, Wang HH, Hassouna MF

399. Application across species of a one health approach to liquid sample handling for respiratory based -omics analysis.

Sci Rep

2021 Jul 12

Karagianni AE, Eaton SL, Kurian D

Airway inflammation is highly prevalent in horses, with the majority of non-infectious cases being defined as equine asthma. Currently, cytological analysis of airway derived samples is the principal method of assessing lower airway inflammation. Samples can be obtained by tracheal wash (TW) or by lavage of the lower respiratory tract (bronchoalveolar lavage (BAL) fluid; BALF). Although BALF cytology carries significant diagnostic advantages over TW cytology for the diagnosis of equine asthma, sample acquisition is invasive, making it prohibitive for routine and sequential screening of airway health. However, recent technological advances in sample collection and processing have made it possible to determine whether a wider range of analyses might be applied to TW samples. Considering that TW samples are relatively simple to collect, minimally invasive and readily available in the horse, it was considered appropriate to investigate whether, equine tracheal secretions represent a rich source of cells and both transcriptomic and proteomic data. Similar approaches have already been applied to a comparable sample set in humans; namely, induced sputum. Sputum represents a readily available source of airway biofluids enriched in proteins, changes in the expression of which may reveal novel mechanisms in the pathogenesis of respiratory diseases, such as asthma and chronic obstructive pulmonary disease. The aim of this study was to establish a robust protocol to isolate macrophages, protein and RNA for molecular characterization of TW samples and demonstrate the applicability of sample handling to rodent and human pediatric bronchoalveolar lavage fluid isolates. TW samples provided a good quality and yield of both RNA and protein for downstream transcriptomic/proteomic analyses. The sample handling methodologies were successfully applicable to BALF for rodent and human research. TW samples represent a rich source of airway cells, and molecular analysis to facilitate and study airway inflammation, based on both transcriptomic and proteomic analysis. This study provides a necessary methodological platform for future transcriptomic and/or proteomic studies on equine lower respiratory tract secretions and BALF samples from humans and mice.

400. Evolutionary loss of thermal acclimation accompanied by periodic monocarpic mass flowering in Strobilanthes flexicaulis.

Sci Rep

2021 Jul 12

Ishida A, Nakamura T, Saiki ST

401. Cold bubble humidification of low-flow oxygen does not prevent acute changes in inflammation and oxidative stress at nasal mucosa.

Sci Rep

2021 Jul 12

Santana LA, Bezerra SKM, Saraiva-Romanholo BM

402. Effect of gold nanoparticles on the structure and neuroprotective function of protein L-isoaspartyl methyltransferase (PIMT).

Sci Rep

2021 Jul 12

Chatterjee T, Das G, Ghosh S

403. Ocular surface disorders associated with the use of dupilumab based on WHO VigiBase.

Sci Rep

2021 Jul 12

Park S(#), Lee JH(#), Park JH

404. A HML6 endogenous retrovirus on chromosome 3 is upregulated in amyotrophic lateral sclerosis motor cortex.

Sci Rep

2021 Jul 12

Jones AR, Iacoangeli A, Adey BN

405. Toward applications of near-field radiative heat transfer with micro-hotplates.

Sci Rep

2021 Jul 12

Marconot O, Juneau-Fecteau A, Fréchette LG.

406. Visual outcome of endogenous endophthalmitis in Thailand.

Sci Rep

2021 Jul 12

Lourthai P, Choopong P, Dhirachaikulpanich D

407. Climate change and tree growth in the Khakass-Minusinsk Depression (South Siberia) impacted by large water reservoirs.

Sci Rep

2021 Jul 12

Zhirnova DF, Belokopytova LV, Meko DM

408. Untargeted metabolomics analysis of Ralstonia eutropha during plant oil cultivations reveals the presence of a fucose salvage pathway.

Sci Rep

2021 Jul 12

Gutschmann B, Bock MCE, Jahns S

409. Heat-tolerant hot pepper exhibits constant photosynthesis via increased transpiration rate, high proline content and fast recovery in heat stress condition.

Sci Rep

2021 Jul 12

Rajametov SN(#), Yang EY(#), Cho MC

410. Canine D(163)-PrP polymorphic variant does not provide complete protection against prion infection in small ruminant PrP context.

Sci Rep

2021 Jul 12

Marín-Moreno A, Espinosa JC, Aguilar-Calvo P

411. Dual effects of 9-cis retinoic acid on ACTH-dependent hyperplastic adrenal tissues.

Sci Rep

2021 Jul 12

Pecori Giraldi F, Sesta A, Tapella L

412. Clinical usefulness of 16S ribosomal RNA real-time PCR for the diagnosis of scrub typhus.

Sci Rep

2021 Jul 12

Yun NR, Kim CM, Kim DY

413. In-vitro, in-vivo, and in-silico assessment of radical scavenging and cytotoxic activities of Oliveria decumbens essential oil and its main components.

Sci Rep

2021 Jul 12

Jamali T, Kavoosi G, Jamali Y

We aimed to explore and compare new insights on the pharmacological potential of Oliveria decumbence essential oil (OEO) and its main components highlighting their antioxidant activity in-vitro, in-vivo, and in-silico and also cytotoxic effects of OEO against A549 lung cancer cells. At first, based on GC-MS analysis, thymol, carvacrol, p-cymene, and γ-terpinene were introduced as basic ingredients of OEO and their in-vitro antioxidant capacity was considered by standard methods. Collectively, OEO exhibited strong antioxidant properties even more than its components. In LPS-stimulated macrophages treated with OEO, the reduction of ROS (Reactive-oxygen-species) and NO (nitric-oxide) and down-regulation of iNOS (inducible nitric-oxide-synthase) and NOX (NADPH-oxidase) mRNA expression was observed and compared with that of OEO components. According to the results, OEO, thymol, and carvacrol exhibited the highest radical scavenging potency compared to p-cymene, and γ-terpinene. In-silico Molecular-Docking and Molecular-Dynamics simulation indicated that thymol and carvacrol but no p-cymene and γ-terpinene may establish coordinative bonds in iNOS active site and thereby inhibit iNOS. However, they did not show any evidence for NOX inhibition. In the following, MTT assay showed that OEO induces cytotoxicity in A549 cancer cells despite having a limited effect on L929 normal cells. Apoptotic death and its dependence on caspase-3 activity and Bax/Bcl2 ratio in OEO-treated cells were established by fluorescence microscopy, flow cytometry, colorimetric assay, and western blot analysis. Additionally, flow cytometry studies demonstrated increased levels of ROS in OEO-treated cells. Therefore, OEO, despite showing antioxidant properties, induces apoptosis in cancer cells by increasing ROS levels. Collectively, our results provided new insight into the usage of OEO and main components, thymol, and carvacrol, into the development of novel antioxidant and anti-cancer agents.

414. Analyses of Gnai3-iresGFP reporter mice reveal unknown Gα(i3) expression sites.

Sci Rep

2021 Jul 12

Leiss V, Reisinger E, Speidel A

415. Computing the orientational-average of diffusion-weighted MRI signals: a comparison of different techniques.

Sci Rep

2021 Jul 12

Afzali M, Knutsson H, Özarslan E

416. Interpretable deep learning for the remote characterisation of ambulation in multiple sclerosis using smartphones.

Sci Rep

2021 Jul 12

Creagh AP, Lipsmeier F, Lindemann M

The emergence of digital technologies such as smartphones in healthcare applications have demonstrated the possibility of developing rich, continuous, and objective measures of multiple sclerosis (MS) disability that can be administered remotely and out-of-clinic. Deep Convolutional Neural Networks (DCNN) may capture a richer representation of healthy and MS-related ambulatory characteristics from the raw smartphone-based inertial sensor data than standard feature-based methodologies. To overcome the typical limitations associated with remotely generated health data, such as low subject numbers, sparsity, and heterogeneous data, a transfer learning (TL) model from similar large open-source datasets was proposed. Our TL framework leveraged the ambulatory information learned on human activity recognition (HAR) tasks collected from wearable smartphone sensor data. It was demonstrated that fine-tuning TL DCNN HAR models towards MS disease recognition tasks outperformed previous Support Vector Machine (SVM) feature-based methods, as well as DCNN models trained end-to-end, by upwards of 8-15%. A lack of transparency of "black-box" deep networks remains one of the largest stumbling blocks to the wider acceptance of deep learning for clinical applications. Ensuing work therefore aimed to visualise DCNN decisions attributed by relevance heatmaps using Layer-Wise Relevance Propagation (LRP). Through the LRP framework, the patterns captured from smartphone-based inertial sensor data that were reflective of those who are healthy versus people with MS (PwMS) could begin to be established and understood. Interpretations suggested that cadence-based measures, gait speed, and ambulation-related signal perturbations were distinct characteristics that distinguished MS disability from healthy participants. Robust and interpretable outcomes, generated from high-frequency out-of-clinic assessments, could greatly augment the current in-clinic assessment picture for PwMS, to inform better disease management techniques, and enable the development of better therapeutic interventions.

417. Renal denervation does not affect hypertension or the renin-angiotensin system in a rodent model of juvenile-onset polycystic kidney disease: clinical implications.

Sci Rep

2021 Jul 12

Li S, Hildreth CM, Rahman AA

418. Characterization of microglial transcriptomes in the brain and spinal cord of mice in early and late experimental autoimmune encephalomyelitis using a RiboTag strategy.

Sci Rep

2021 Jul 12

Acharjee S(#), Gordon PMK(#), Lee BH

419. Individual differences in human frequency-following response predict pitch labeling ability.

Sci Rep

2021 Jul 12

Reis KS, Heald SLM, Veillette JP

420. Movement patterns and activity levels are shaped by the neonatal environment in Antarctic fur seal pups.

Sci Rep

2021 Jul 12

Nagel R, Mews S, Adam T

421. Visualization of three-dimensional microcirculation of rodents' retina and choroid for studies of critical illness using optical coherence tomography angiography.

Sci Rep

2021 Jul 12

Park JR(#), Lee B(#), Lee MJ

422. Photoneuromodulation makes a difficult cognitive task less arduous.

Sci Rep

2021 Jul 1

Chan AS, Lee TL, Hamblin MR

423. Local application of Usag-1 siRNA can promote tooth regeneration in Runx2-deficient mice.

Sci Rep

2021 Jul 1

Mishima S, Takahashi K, Kiso H

424. The origin and radiation of the phosphoprotein phosphatase (PPP) enzymes of Eukaryotes.

Sci Rep

2021 Jul 1

Kerk D, Mattice JF, Valdés-Tresanco ME

425. Canagliflozin protects against sepsis capillary leak syndrome by activating endothelial α1AMPK.

Sci Rep

2021 Jul 1

Angé M, De Poortere J, Ginion A

426. Time-frequency time-space long short-term memory networks for image classification of histopathological tissue.

Sci Rep

2021 Jul 1

Pham TD.

427. Nerve influence on the metabolism of type I and type II diabetic corneal stroma: an in vitro study.

Sci Rep

2021 Jul 1

Whelchel AE, Nicholas SE, Ma JX

428. Introducing the novel Cytoscape app TimeNexus to analyze time-series data using temporal MultiLayer Networks (tMLNs).

Sci Rep

2021 Jul 1

Pierrelée M, Reynders A, Lopez F

Integrating -omics data with biological networks such as protein-protein interaction networks is a popular and useful approach to interpret expression changes of genes in changing conditions, and to identify relevant cellular pathways, active subnetworks or network communities. Yet, most -omics data integration tools are restricted to static networks and therefore cannot easily be used for analyzing time-series data. Determining regulations or exploring the network structure over time requires time-dependent networks which incorporate time as one component in their structure. Here, we present a method to project time-series data on sequential layers of a multilayer network, thus creating a temporal multilayer network (tMLN). We implemented this method as a Cytoscape app we named TimeNexus. TimeNexus allows to easily create, manage and visualize temporal multilayer networks starting from a combination of node and edge tables carrying the information on the temporal network structure. To allow further analysis of the tMLN, TimeNexus creates and passes on regular Cytoscape networks in form of static versions of the tMLN in three different ways: (i) over the entire set of layers, (ii) over two consecutive layers at a time, (iii) or on one single layer at a time. We combined TimeNexus with the Cytoscape apps PathLinker and AnatApp/ANAT to extract active subnetworks from tMLNs. To test the usability of our app, we applied TimeNexus together with PathLinker or ANAT on temporal expression data of the yeast cell cycle and were able to identify active subnetworks relevant for different cell cycle phases. We furthermore used TimeNexus on our own temporal expression data from a mouse pain assay inducing hindpaw inflammation and detected active subnetworks relevant for an inflammatory response to injury, including immune response, cell stress response and regulation of apoptosis. TimeNexus is freely available from the Cytoscape app store at https://apps.cytoscape.org/apps/TimeNexus .

429. Machine learning compensates fold-change method and highlights oxidative phosphorylation in the brain transcriptome of Alzheimer's disease.

Sci Rep

2021 Jul 1

Cheng J(#), Liu HP(#), Lin WY

430. MYCO-TB: the first IVD kit suitable for the digestion and decontamination of extra-pulmonary specimens to detect Mycobacteria.

Sci Rep

2021 Jul 1

Bisognin F, Lombardi G, Felici S

431. Alterations of sleep quality and circadian rhythm genes expression in elderly thyroid nodule patients and risks associated with thyroid malignancy.

Sci Rep

2021 Jul 1

Lou X, Wang H, Tu Y

432. A region within the third extracellular loop of rat Aquaporin 6 precludes trafficking to plasma membrane in a heterologous cell line.

Sci Rep

2021 Jul 1

Soler DC, Kowatz T, Sloan AE

433. Neural network-crow search model for the prediction of functional properties of nano TiO(2) coated cotton composites.

Sci Rep

2021 Jul 1

Amor N, Noman MT, Petru M

434. Comparison of machine learning methods to predict udder health status based on somatic cell counts in dairy cows.

Sci Rep

2021 Jul 1

Bobbo T, Biffani S, Taccioli C

435. On the phenomena of partial crystallization of highly undercooled magnesium silicate molten droplets.

Sci Rep

2021 Jul 1

Shete G, Mishra S, Karagadde S

436. Spatiotemporal analysis of COVID-19 outbreaks in Wuhan, China.

Sci Rep

2021 Jul 1

Liu W(#), Wang D(#), Hua S(#)

437. The RNA sensor MDA5 detects SARS-CoV-2 infection.

Sci Rep

2021 Jul 1

Sampaio NG(#), Chauveau L(#), Hertzog J(#)

438. Virtually spatialized sounds enhance auditory processing in healthy participants and patients with a disorder of consciousness.

Sci Rep

2021 Jul 1

Heine L, Corneyllie A, Gobert F

439. Plasma concentrations of granulocyte colony-stimulating factor (G-CSF) in patients with substance use disorders and comorbid major depressive disorder.

Sci Rep

2021 Jul 1

Galván ST(#), Flores-López M(#), Romero-Sanchiz P

Granulocyte colony-stimulating factor (G-CSF) has raised much interest because of its role in cocaine addiction in preclinical models. We explored the plasma concentrations of G-CSF in patients diagnosed with substance use disorder (SUD) and highly comorbid psychiatric disorders. In particular, we investigated the association between G-CSF concentrations and comorbid major depressive disorder (MDD) in patients with cocaine and alcohol use disorders (CUD and AUD, respectively). Additionally, patients with MDD but not SUD were included in the study. Three hundred and eleven participants were enrolled in this exploratory study: 136 control subjects, 125 patients with SUD (SUD group) from outpatient treatment programs for cocaine (N = 60, cocaine subgroup) and alcohol (N = 65, alcohol subgroup), and 50 patients with MDD but not SUD (MDD group) from primary-care settings. Participants were assessed based on DSM-IV-TR criteria, and a blood sample was collected to examine the plasma concentrations of G-CSF. G-CSF concentrations were negatively correlated with age in the entire sample (r = - 0.233, p < 0.001) but not in the patients with MDD. G-CSF concentrations were lower in patients with SUD than in controls (p < 0.05), specifically in the cocaine subgroup (p < 0.05). Patients with SUD and comorbid MDD had lower G-CSF concentrations than patients with SUD but not comorbid MDD or controls (p < 0.05). In contrast, patients with MDD but not SUD showed no differences compared with their controls. The negative association between G-CSF concentrations and age in the sample was not observed in patients with MDD. G-CSF concentrations were decreased in patients with SUD and comorbid MDD but not in patients with MDD. Therefore, G-CSF may be useful to improve the stratification of patients with dual diagnosis seeking treatment. Further investigation is needed to explore the impact of sex and type of drug on the expression of G-CSF.

440. Long-term efficacy and safety of bone cement-augmented pedicle screw fixation for stage III Kümmell disease.

Sci Rep

2021 Jul 1

Mo GY(#), Zhou TP(#), Guo HZ

441. Sediment and morphological changes along Yangtze River's 500 km between Datong and Xuliujing before and after Three Gorges Dam commissioning.

Sci Rep

2021 Jul 1

Xie Q, Yang J, Lundström TS.

442. Novel mumps virus epitopes reveal robust cytotoxic T cell responses after natural infection but not after vaccination.

Sci Rep

2021 Jul 1

Kaaijk P, Emmelot ME, Meiring HD

443. A Bayesian approach to extracting free-energy profiles from cryo-electron microscopy experiments.

Sci Rep

2021 Jul 1

Giraldo-Barreto J(#), Ortiz S(#), Thiede EH

444. Incremental changes in QRS duration as predictor for cardiovascular disease: a 21-year follow-up of a randomly selected general population.

Sci Rep

2021 Jul 1

Chen X, Hansson PO, Thunström E

445. Electroacupuncture prevents cocaine-induced conditioned place preference reinstatement and attenuates ΔFosB and GluR2 expression.

Sci Rep

2021 Jul 1

Nguyen ATM, Quach TVB, Kotha P

446. Focal intra-colon cooling reduces organ injury and systemic inflammation after REBOA management of lethal hemorrhage in rats.

Sci Rep

2021 Jul 1

Arya AK, Hu K, Subedi L

Resuscitative endovascular balloon occlusion of the aorta (REBOA) is a lifesaving maneuver for the management of lethal torso hemorrhage. However, its prolonged use leads to distal organ ischemia-reperfusion injury (IRI) and systemic inflammatory response syndrome (SIRS). The objective of this study is to investigate the blood-based biomarkers of IRI and SIRS and the efficacy of direct intestinal cooling in the prevention of IRI and SIRS. A rat lethal hemorrhage model was produced by bleeding 50% of the total blood volume. A balloon catheter was inserted into the aorta for the implementation of REBOA. A novel TransRectal Intra-Colon (TRIC) device was placed in the descending colon and activated from 10 min after the bleeding to maintain the intra-colon temperature at 37 °C (TRIC37°C group) or 12 °C (TRIC12°C group) for 270 min. The upper body temperature was maintained at as close to 37 °C as possible in both groups. Blood samples were collected before hemorrhage and after REBOA. The organ injury biomarkers and inflammatory cytokines were evaluated by ELISA method. Blood based organ injury biomarkers (endotoxin, creatinine, AST, FABP1/L-FABP, cardiac troponin I, and FABP2/I-FABP) were all drastically increased in TRIC37°C group after REBOA. TRIC12°C significantly downregulated these increased organ injury biomarkers. Plasma levels of pro-inflammatory cytokines TNF-α, IL-1b, and IL-17F were also drastically increased in TRIC37°C group after REBOA. TRIC12°C significantly downregulated the pro-inflammatory cytokines. In contrast, TRIC12°C significantly upregulated the levels of anti-inflammatory cytokines IL-4 and IL-10 after REBOA. Amazingly, the mortality rate was 100% in TRIC37°C group whereas 0% in TRIC12°C group after REBOA. Directly cooling the intestine offered exceptional protection of the abdominal organs from IRI and SIRS, switched from a harmful pro-inflammatory to a reparative anti-inflammatory response, and mitigated mortality in the rat model of REBOA management of lethal hemorrhage.

447. Phylogeography of Prunus armeniaca L. revealed by chloroplast DNA and nuclear ribosomal sequences.

Sci Rep

2021 Jul 1

Li WW, Liu LQ, Zhang QP

448. Mosquito species identification using convolutional neural networks with a multitiered ensemble model for novel species detection.

Sci Rep

2021 Jul 1

Goodwin A, Padmanabhan S, Hira S

449. Underrecognition and undertreatment of thirst among hospitalized patients with restricted oral feeding and drinking.

Sci Rep

2021 Jul 1

Ho V, Goh G, Tang XR

450. The interindividual variability of sleep timing and circadian phase in humans is influenced by daytime and evening light conditions.

Sci Rep

2021 Jul 1

Papatsimpa C, Schlangen LJM, Smolders KCHJ

Newmer生物

Newmer生物