Author information: (1)Population Health Research Institute, David Braley Cardiac, Vascular and Stroke Research Institute, 237 Barton Street East, Hamilton, ON, Canada. (2)Department of Medicine, McMaster University, 1280 Main Street West, L8S 4K1, Hamilton, ON, Canada. (3)Department of Pediatrics, University of Alberta, Edmonton, AB, Canada. (4)Department of Pediatrics and Child Health, Children's Hospital Research Institute of Manitoba, University of Manitoba, Winnipeg, MB, Canada. (5)Department of Pediatrics, Hospital for Sick Children, ON, Toronto, Canada. (6)Department of Pediatrics, BC Children's Hospital, University of British Columbia, Vancouver, BC, Canada. (7)Thrombosis and Atherosclerosis Research Institute, David Braley Cardiac, Vascular and Stroke Research Institute, 237 Barton Street East, Hamilton, ON, Canada. (8)Department of Pathology and Molecular Medicine, Michael G. DeGroote School of Medicine, McMaster University, 1280 Main Street West, Hamilton, ON, Canada. (9)Department of Clinical Epidemiology & Biostatistics, McMaster University, 1280 Main Street West, Hamilton, ON, Canada. (10)Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, Ontario, Canada. (11)Population Health Research Institute, David Braley Cardiac, Vascular and Stroke Research Institute, 237 Barton Street East, Hamilton, ON, Canada. anands@mcmaster.ca. (12)Department of Medicine, McMaster University, 1280 Main Street West, L8S 4K1, Hamilton, ON, Canada. anands@mcmaster.ca. (13)Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, Ontario, Canada. anands@mcmaster.ca. (#)Contributed equally