Author information: (1)Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA. (2)Department of Pathology, Brigham and Women's Hospital, Boston, MA, USA. (3)Broad Institute of Massachusetts Institute of Technology and Harvard University, Cambridge, MA, USA. (4)Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA. (5)Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA, USA. (6)Division of Genetic Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA. (7)Yale University School of Medicine, New Haven, CT, USA. (8)Department of Ophthalmology, Harvard Medical School, Boston, MA, USA. (9)Department of Laboratory Medicine, Lund University, Lund, Sweden. (10)Division of Cardiology, University of California San Francisco, San Francisco, CA, USA. (11)Neuroendocrine Unit, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA. (12)Department of Medicine, Harvard Medical School, Boston, MA, USA. (13)Department of Pathology, Dana-Farber Cancer Institute, Boston, MA, USA. (14)Division of Cardiovascular Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA. (15)Department of Haematology, UCL Cancer Institute, London, UK. (16)Department of Biostatistics, Center for Statistical Genetics, University of Michigan School of Public Health, Ann Arbor, MI, USA. (17)Section of Gastroenterology, Boston Medical Center, Boston University School of Medicine, Boston, MA, USA. (18)Department of Epidemiology, Human Genetics and Environmental Sciences, School of Public Health, University of Texas Health Science Center at Houston, Houston, TX, USA. (19)Human Genetics Center, Department of Epidemiology, Human Genetics and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, USA. (20)Perspectum Ltd, Oxford, UK. (21)Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA. (22)Department of Genetics, Harvard Medical School, Boston, MA, USA. (23)Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX, USA. (24)The University of Texas School of Public Health San Antonio, San Antonio, TX, USA. (25)Framingham Heart Study of the NHLBI and Boston University School of Medicine, Framingham, MA, USA. (26)The University of Texas Health Science Center, San Antonio, TX, USA. (27)Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA. (28)Population Sciences Branch, National Heart, Lung, and Blood Institute, Framingham, MA, USA. (29)Liver Center, Division of Gastroenterology, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA. (30)Population Sciences Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA. (31)Department of Medicine, Baylor College of Medicine, Houston, TX, USA. (32)Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA. (33)Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA. Benjamin_Ebert@dfci.harvard.edu. (34)Broad Institute of Massachusetts Institute of Technology and Harvard University, Cambridge, MA, USA. Benjamin_Ebert@dfci.harvard.edu. (35)Department of Medicine, Harvard Medical School, Boston, MA, USA. Benjamin_Ebert@dfci.harvard.edu. (36)Howard Hughes Medical Institute, Dana-Farber Cancer Institute, Boston, MA, USA. Benjamin_Ebert@dfci.harvard.edu. (37)Broad Institute of Massachusetts Institute of Technology and Harvard University, Cambridge, MA, USA. pnatarajan@mgh.harvard.edu. (38)Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA. pnatarajan@mgh.harvard.edu. (39)Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA, USA. pnatarajan@mgh.harvard.edu. (40)Department of Medicine, Harvard Medical School, Boston, MA, USA. pnatarajan@mgh.harvard.edu. (#)Contributed equally